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O95622

- ADCY5_HUMAN

UniProt

O95622 - ADCY5_HUMAN

Protein

Adenylate cyclase type 5

Gene

ADCY5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 3 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    This is a membrane-bound, calcium-inhibitable adenylyl cyclase.

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.

    Cofactori

    Binds 2 magnesium ions per subunit.By similarity

    Enzyme regulationi

    Inhibition by calcium in the submicromolar concentration range By similarity. Phosphorylation by RAF1 results in its activation.By similarity1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi474 – 4741Magnesium 1PROSITE-ProRule annotation
    Metal bindingi474 – 4741Magnesium 2PROSITE-ProRule annotation
    Metal bindingi475 – 4751Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
    Metal bindingi518 – 5181Magnesium 1PROSITE-ProRule annotation
    Metal bindingi518 – 5181Magnesium 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. adenylate cyclase activity Source: UniProtKB-EC
    2. adenylate cyclase binding Source: BHF-UCL
    3. ATP binding Source: UniProtKB-KW
    4. metal ion binding Source: UniProtKB-KW
    5. protein heterodimerization activity Source: BHF-UCL

    GO - Biological processi

    1. activation of phospholipase C activity Source: Reactome
    2. activation of protein kinase A activity Source: Reactome
    3. adenosine receptor signaling pathway Source: Ensembl
    4. adenylate cyclase-activating dopamine receptor signaling pathway Source: Ensembl
    5. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Reactome
    6. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: Ensembl
    7. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Reactome
    8. cellular response to glucagon stimulus Source: Reactome
    9. energy reserve metabolic process Source: Reactome
    10. epidermal growth factor receptor signaling pathway Source: Reactome
    11. fibroblast growth factor receptor signaling pathway Source: Reactome
    12. innate immune response Source: Reactome
    13. intracellular signal transduction Source: InterPro
    14. locomotory behavior Source: Ensembl
    15. neuromuscular process controlling balance Source: Ensembl
    16. neurotrophin TRK receptor signaling pathway Source: Reactome
    17. signal transduction Source: Reactome
    18. small molecule metabolic process Source: Reactome
    19. synaptic transmission Source: Reactome
    20. transmembrane transport Source: Reactome
    21. water transport Source: Reactome

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi4.6.1.1. 2681.
    ReactomeiREACT_15312. Adenylate cyclase activating pathway.
    REACT_15333. Adenylate cyclase inhibitory pathway.
    REACT_15530. PKA activation.
    REACT_1665. Glucagon signaling in metabolic regulation.
    REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
    REACT_19231. G alpha (i) signalling events.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_1946. PKA activation in glucagon signalling.
    REACT_24023. Regulation of water balance by renal Aquaporins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase type 5 (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase 5
    Adenylate cyclase type V
    Adenylyl cyclase 5
    Gene namesi
    Name:ADCY5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:236. ADCY5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: BHF-UCL
    3. primary cilium Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Cilium, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Dyskinesia, familial, with facial myokymia (FDFM) [MIM:606703]: A disorder characterized by predominantly perioral and periorbital myokymia, and face, neck and upper limb dystonic/choreic movements. Initially paroxysmal and worsened by stress, the dyskinetic episodes become nearly constant by the end of the third decade of life, but in some individuals, they may diminish in frequency and severity at older ages.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti726 – 7261A → T in FDFM. 1 Publication
    VAR_068821

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi606703. phenotype.
    Orphaneti324588. Familial dyskinesia and facial myokymia.
    PharmGKBiPA24563.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12611261Adenylate cyclase type 5PRO_0000195694Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi870 – 8701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi887 – 8871N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated by RAF1.1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiO95622.
    PRIDEiO95622.

    PTM databases

    PhosphoSiteiO95622.

    Expressioni

    Gene expression databases

    ArrayExpressiO95622.
    BgeeiO95622.
    CleanExiHS_ADCY5.
    GenevestigatoriO95622.

    Organism-specific databases

    HPAiHPA017730.

    Interactioni

    Subunit structurei

    Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2 By similarity. Interacts with RAF1.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi106624. 14 interactions.
    STRINGi9606.ENSP00000419361.

    Structurei

    3D structure databases

    ProteinModelPortaliO95622.
    SMRiO95622. Positions 454-643, 1064-1255.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 195195CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini395 – 769375CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini857 – 90953ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1005 – 1261257CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei196 – 21621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei242 – 26221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei299 – 31921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei325 – 34521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei374 – 39421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei770 – 79021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei792 – 81221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei836 – 85621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei910 – 93021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei935 – 95521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei984 – 100421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini469 – 596128Guanylate cyclase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1071 – 1210140Guanylate cyclase 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
    Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2114.
    HOGENOMiHOG000006941.
    HOVERGENiHBG050458.
    InParanoidiO95622.
    KOiK08045.
    OMAiVRSKMNS.
    OrthoDBiEOG7B8S30.
    PhylomeDBiO95622.
    TreeFamiTF313845.

    Family and domain databases

    Gene3Di3.30.70.1230. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view]
    PfamiPF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    SMARTiSM00044. CYCc. 2 hits.
    [Graphical view]
    SUPFAMiSSF55073. SSF55073. 2 hits.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95622-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGSKSVSPP GYAAQKTAAP APRGGPEHRS AWGEADSRAN GYPHAPGGSA     50
    RGSTKKPGGA VTPQQQQRLA SRWRSDDDDD PPLSGDDPLA GGFGFSFRSK 100
    SAWQERGGDD CGRGSRRQRR GAASGGSTRA PPAGGGGGSA AAAASAGGTE 150
    VRPRSVEVGL EERRGKGRAA DELEAGAVEG GEGSGDGGSS ADSGSGAGPG 200
    AVLSLGACCL ALLQIFRSKK FPSDKLERLY QRYFFRLNQS SLTMLMAVLV 250
    LVCLVMLAFH AARPPLQLPY LAVLAAAVGV ILIMAVLCNR AAFHQDHMGL 300
    ACYALIAVVL AVQVVGLLLP QPRSASEGIW WTVFFIYTIY TLLPVRMRAA 350
    VLSGVLLSAL HLAIALRTNA QDQFLLKQLV SNVLIFSCTN IVGVCTHYPA 400
    EVSQRQAFQE TRECIQARLH SQRENQQQER LLLSVLPRHV AMEMKADINA 450
    KQEDMMFHKI YIQKHDNVSI LFADIEGFTS LASQCTAQEL VMTLNELFAR 500
    FDKLAAENHC LRIKILGDCY YCVSGLPEAR ADHAHCCVEM GMDMIEAISL 550
    VREVTGVNVN MRVGIHSGRV HCGVLGLRKW QFDVWSNDVT LANHMEAGGK 600
    AGRIHITKAT LNYLNGDYEV EPGCGGERNA YLKEHSIETF LILRCTQKRK 650
    EEKAMIAKMN RQRTNSIGHN PPHWGAERPF YNHLGGNQVS KEMKRMGFED 700
    PKDKNAQESA NPEDEVDEFL GRAIDARSID RLRSEHVRKF LLTFREPDLE 750
    KKYSKQVDDR FGAYVACASL VFLFICFVQI TIVPHSIFML SFYLTCSLLL 800
    TLVVFVSVIY SCVKLFPSPL QTLSRKIVRS KMNSTLVGVF TITLVFLAAF 850
    VNMFTCNSRD LLGCLAQEHN ISASQVNACH VAESAVNYSL GDEQGFCGSP 900
    WPNCNFPEYF TYSVLLSLLA CSVFLQISCI GKLVLMLAIE LIYVLIVEVP 950
    GVTLFDNADL LVTANAIDFF NNGTSQCPEH ATKVALKVVT PIIISVFVLA 1000
    LYLHAQQVES TARLDFLWKL QATEEKEEME ELQAYNRRLL HNILPKDVAA 1050
    HFLARERRND ELYYQSCECV AVMFASIANF SEFYVELEAN NEGVECLRLL 1100
    NEIIADFDEI ISEDRFRQLE KIKTIGSTYM AASGLNDSTY DKVGKTHIKA 1150
    LADFAMKLMD QMKYINEHSF NNFQMKIGLN IGPVVAGVIG ARKPQYDIWG 1200
    NTVNVASRMD STGVPDRIQV TTDMYQVLAA NTYQLECRGV VKVKGKGEMM 1250
    TYFLNGGPPL S 1261
    Length:1,261
    Mass (Da):138,908
    Last modified:November 28, 2006 - v3
    Checksum:iC50492A0B053694F
    GO
    Isoform 2 (identifier: O95622-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-28: MSGSKSVSPPGYAAQKTAAPAPRGGPEH → MKSQKEGCCSRGDLSIQTGPGGEWAPRR
         29-378: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:911
    Mass (Da):102,606
    Checksum:iCA9E766B744A6222
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti726 – 7261A → T in FDFM. 1 Publication
    VAR_068821

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2828MSGSK…GGPEH → MKSQKEGCCSRGDLSIQTGP GGEWAPRR in isoform 2. 1 PublicationVSP_042914Add
    BLAST
    Alternative sequencei29 – 378350Missing in isoform 2. 1 PublicationVSP_042915Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK303070 mRNA. Translation: BAH13892.1.
    AC025571 Genomic DNA. No translation available.
    AC112503 Genomic DNA. No translation available.
    AF497517 mRNA. Translation: AAM94374.1.
    U65473 mRNA. Translation: AAD00121.1.
    BK000371 mRNA. Translation: DAA00057.1.
    CCDSiCCDS3022.1. [O95622-1]
    CCDS56274.1. [O95622-2]
    RefSeqiNP_001186571.1. NM_001199642.1. [O95622-2]
    NP_899200.1. NM_183357.2. [O95622-1]
    UniGeneiHs.593292.

    Genome annotation databases

    EnsembliENST00000309879; ENSP00000308685; ENSG00000173175. [O95622-2]
    ENST00000462833; ENSP00000419361; ENSG00000173175. [O95622-1]
    GeneIDi111.
    KEGGihsa:111.
    UCSCiuc003egh.2. human. [O95622-1]
    uc003egi.1. human. [O95622-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK303070 mRNA. Translation: BAH13892.1 .
    AC025571 Genomic DNA. No translation available.
    AC112503 Genomic DNA. No translation available.
    AF497517 mRNA. Translation: AAM94374.1 .
    U65473 mRNA. Translation: AAD00121.1 .
    BK000371 mRNA. Translation: DAA00057.1 .
    CCDSi CCDS3022.1. [O95622-1 ]
    CCDS56274.1. [O95622-2 ]
    RefSeqi NP_001186571.1. NM_001199642.1. [O95622-2 ]
    NP_899200.1. NM_183357.2. [O95622-1 ]
    UniGenei Hs.593292.

    3D structure databases

    ProteinModelPortali O95622.
    SMRi O95622. Positions 454-643, 1064-1255.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106624. 14 interactions.
    STRINGi 9606.ENSP00000419361.

    Chemistry

    BindingDBi O95622.
    ChEMBLi CHEMBL2097167.
    GuidetoPHARMACOLOGYi 1282.

    PTM databases

    PhosphoSitei O95622.

    Proteomic databases

    PaxDbi O95622.
    PRIDEi O95622.

    Protocols and materials databases

    DNASUi 111.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309879 ; ENSP00000308685 ; ENSG00000173175 . [O95622-2 ]
    ENST00000462833 ; ENSP00000419361 ; ENSG00000173175 . [O95622-1 ]
    GeneIDi 111.
    KEGGi hsa:111.
    UCSCi uc003egh.2. human. [O95622-1 ]
    uc003egi.1. human. [O95622-2 ]

    Organism-specific databases

    CTDi 111.
    GeneCardsi GC03M122949.
    H-InvDB HIX0003612.
    HGNCi HGNC:236. ADCY5.
    HPAi HPA017730.
    MIMi 600293. gene.
    606703. phenotype.
    neXtProti NX_O95622.
    Orphaneti 324588. Familial dyskinesia and facial myokymia.
    PharmGKBi PA24563.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2114.
    HOGENOMi HOG000006941.
    HOVERGENi HBG050458.
    InParanoidi O95622.
    KOi K08045.
    OMAi VRSKMNS.
    OrthoDBi EOG7B8S30.
    PhylomeDBi O95622.
    TreeFami TF313845.

    Enzyme and pathway databases

    BRENDAi 4.6.1.1. 2681.
    Reactomei REACT_15312. Adenylate cyclase activating pathway.
    REACT_15333. Adenylate cyclase inhibitory pathway.
    REACT_15530. PKA activation.
    REACT_1665. Glucagon signaling in metabolic regulation.
    REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
    REACT_19231. G alpha (i) signalling events.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_1946. PKA activation in glucagon signalling.
    REACT_24023. Regulation of water balance by renal Aquaporins.

    Miscellaneous databases

    ChiTaRSi ADCY5. human.
    GeneWikii ADCY5.
    GenomeRNAii 111.
    NextBioi 427.
    PROi O95622.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95622.
    Bgeei O95622.
    CleanExi HS_ADCY5.
    Genevestigatori O95622.

    Family and domain databases

    Gene3Di 3.30.70.1230. 2 hits.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view ]
    Pfami PF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view ]
    SMARTi SM00044. CYCc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55073. SSF55073. 2 hits.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms."
      Ludwig M.G., Seuwen K.
      J. Recept. Signal Transduct. 22:79-110(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 368-1261 (ISOFORM 1).
      Tissue: Heart.
    4. "Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues."
      Raimundo S., Giray J., Volff J.-N., Schwab M., Altenbuchner J., Ratge D., Wisser H.
      Clin. Chim. Acta 285:155-161(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 560-664 (ISOFORM 1).
      Tissue: Heart muscle.
    5. "Raf kinase activation of adenylyl cyclases: isoform-selective regulation."
      Ding Q., Gros R., Gray I.D., Taussig R., Ferguson S.S., Feldman R.D.
      Mol. Pharmacol. 66:921-928(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY RAF1, INTERACTION WITH RAF1, ENZYME REGULATION.
    6. "Autosomal dominant familial dyskinesia and facial myokymia: single exome sequencing identifies a mutation in adenylyl cyclase 5."
      Chen Y.Z., Matsushita M.M., Robertson P., Rieder M., Girirajan S., Antonacci F., Lipe H., Eichler E.E., Nickerson D.A., Bird T.D., Raskind W.H.
      Arch. Neurol. 69:630-635(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT FDFM THR-726.

    Entry informationi

    Entry nameiADCY5_HUMAN
    AccessioniPrimary (citable) accession number: O95622
    Secondary accession number(s): B7Z8A6, Q7RTV7, Q8NFM3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 131 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3