O95622 (ADCY5_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 104.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Adenylate cyclase type 5 EC=4.6.1.1 Alternative name(s): ATP pyrophosphate-lyase 5 Adenylate cyclase type V Adenylyl cyclase 5 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1261 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | This is a membrane-bound, calcium-inhibitable adenylyl cyclase. |
| Catalytic activity | ATP = 3',5'-cyclic AMP + diphosphate. |
| Cofactor | Binds 2 magnesium ions per subunit By similarity. |
| Enzyme regulation | Inhibition by calcium in the submicromolar concentration range By similarity. Phosphorylation by RAF1 results in its activation. Ref.4 |
| Subunit structure | Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2 By similarity. Interacts with RAF1. Ref.4 |
| Subcellular location | Membrane; Multi-pass membrane protein. Cell projection › cilium By similarity. |
| Post-translational modification | Phosphorylated by RAF1. Ref.4 |
| Sequence similarities | Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1261 | 1261 | Adenylate cyclase type 5 | PRO_0000195694 | |||||
Regions | |||||||||
| Topological domain | 1 – 195 | 195 | Cytoplasmic Potential | ||||||
| Transmembrane | 196 – 216 | 21 | Helical; Potential | ||||||
| Transmembrane | 242 – 262 | 21 | Helical; Potential | ||||||
| Transmembrane | 268 – 288 | 21 | Helical; Potential | ||||||
| Transmembrane | 299 – 319 | 21 | Helical; Potential | ||||||
| Transmembrane | 325 – 345 | 21 | Helical; Potential | ||||||
| Transmembrane | 374 – 394 | 21 | Helical; Potential | ||||||
| Topological domain | 395 – 769 | 375 | Cytoplasmic Potential | ||||||
| Transmembrane | 770 – 790 | 21 | Helical; Potential | ||||||
| Transmembrane | 792 – 812 | 21 | Helical; Potential | ||||||
| Transmembrane | 836 – 856 | 21 | Helical; Potential | ||||||
| Topological domain | 857 – 909 | 53 | Extracellular Potential | ||||||
| Transmembrane | 910 – 930 | 21 | Helical; Potential | ||||||
| Transmembrane | 935 – 955 | 21 | Helical; Potential | ||||||
| Transmembrane | 984 – 1004 | 21 | Helical; Potential | ||||||
| Topological domain | 1005 – 1261 | 257 | Cytoplasmic Potential | ||||||
| Domain | 469 – 596 | 128 | Guanylate cyclase 1 | ||||||
| Domain | 1071 – 1210 | 140 | Guanylate cyclase 2 | ||||||
Sites | |||||||||
| Metal binding | 474 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 474 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 475 | 1 | Magnesium 2; via carbonyl oxygen By similarity | ||||||
| Metal binding | 518 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 518 | 1 | Magnesium 2 By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 8 | 1 | Phosphoserine By similarity | ||||||
| Glycosylation | 870 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 887 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. Gibbs R.A.Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms." Ludwig M.G., Seuwen K. J. Recept. Signal Transduct. 22:79-110(2002) [PubMed: 12503609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 368-1261. Tissue: Heart. |
| [3] | "Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues." Raimundo S., Giray J., Volff J.-N., Schwab M., Altenbuchner J., Ratge D., Wisser H. Clin. Chim. Acta 285:155-161(1999) [PubMed: 10481931] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 560-664. Tissue: Heart muscle. |
| [4] | "Raf kinase activation of adenylyl cyclases: isoform-selective regulation." Ding Q., Gros R., Gray I.D., Taussig R., Ferguson S.S., Feldman R.D. Mol. Pharmacol. 66:921-928(2004) [PubMed: 15385642] [Abstract] Cited for: PHOSPHORYLATION BY RAF1, INTERACTION WITH RAF1, ENZYME REGULATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AC025571 Genomic DNA. No translation available. AF497517 mRNA. Translation: AAM94374.1. U65473 mRNA. Translation: AAD00121.1. BK000371 mRNA. Translation: DAA00057.1. |
| IPI | IPI00339214. |
| RefSeq | NP_899200.1. NM_183357.2. |
| UniGene | Hs.593292. |
3D structure databases | |
| ProteinModelPortal | O95622. |
| SMR | O95622. Positions 454-643, 1063-1255. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O95622. |
PTM databases | |
| PhosphoSite | O95622. |
Proteomic databases | |
| PRIDE | O95622. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000462833; ENSP00000419361; ENSG00000173175. |
| GeneID | 111. |
| KEGG | hsa:111. |
| UCSC | uc003egh.1. human. |
Organism-specific databases | |
| CTD | 111. |
| GeneCards | GC03M122949. |
| H-InvDB | HIX0003612. |
| HGNC | HGNC:236. ADCY5. |
| HPA | HPA017730. |
| MIM | 600293. gene. |
| neXtProt | NX_O95622. |
| PharmGKB | PA24563. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG17453. |
| GeneTree | ENSGT00590000082802. |
| HOGENOM | HBG445220. |
| HOVERGEN | HBG050458. |
| InParanoid | O95622. |
| OMA | GDEQGFC. |
| OrthoDB | EOG4255S0. |
| PhylomeDB | O95622. |
Enzyme and pathway databases | |
| BRENDA | 4.6.1.1. 2681. |
| Pathway_Interaction_DB | endothelinpathway. Endothelins. lysophospholipid_pathway. LPA receptor mediated events. lpa4_pathway. LPA4-mediated signaling events. |
| Reactome | REACT_111102. Signal Transduction. REACT_111217. Metabolism. REACT_13685. Neuronal System. REACT_15518. Transmembrane transport of small molecules. |
Gene expression databases | |
| ArrayExpress | O95622. |
| Bgee | O95622. |
| CleanEx | HS_ADCY5. |
| Genevestigator | O95622. |
Family and domain databases | |
| InterPro | IPR001054. A/G_cyclase. IPR018297. A/G_cyclase_CS. IPR009398. Adenylate_cyclase-like. [Graphical view] |
| Gene3D | G3DSA:3.30.70.1230. A/G_cyclase. 2 hits. |
| KO | K08045. |
| Pfam | PF06327. DUF1053. 1 hit. PF00211. Guanylate_cyc. 2 hits. [Graphical view] |
| SMART | SM00044. CYCc. 2 hits. [Graphical view] |
| SUPFAM | SSF55073. A/G_cyclase. 2 hits. |
| PROSITE | PS00452. GUANYLATE_CYCLASE_1. 2 hits. PS50125. GUANYLATE_CYCLASE_2. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 427. |
| SOURCE | Search... |
Entry information
| Entry name | ADCY5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O95622 Secondary accession number(s): Q7RTV7, Q8NFM3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with