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O95622

- ADCY5_HUMAN

UniProt

O95622 - ADCY5_HUMAN

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Protein

Adenylate cyclase type 5

Gene

ADCY5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This is a membrane-bound, calcium-inhibitable adenylyl cyclase.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Binds 2 magnesium ions per subunit.By similarity

Enzyme regulationi

Inhibition by calcium in the submicromolar concentration range By similarity. Phosphorylation by RAF1 results in its activation.By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi474 – 4741Magnesium 1PROSITE-ProRule annotation
Metal bindingi474 – 4741Magnesium 2PROSITE-ProRule annotation
Metal bindingi475 – 4751Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi518 – 5181Magnesium 1PROSITE-ProRule annotation
Metal bindingi518 – 5181Magnesium 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. adenylate cyclase activity Source: UniProtKB-EC
  2. adenylate cyclase binding Source: BHF-UCL
  3. ATP binding Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW
  5. protein heterodimerization activity Source: BHF-UCL

GO - Biological processi

  1. activation of phospholipase C activity Source: Reactome
  2. activation of protein kinase A activity Source: Reactome
  3. adenosine receptor signaling pathway Source: Ensembl
  4. adenylate cyclase-activating dopamine receptor signaling pathway Source: Ensembl
  5. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Reactome
  6. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: Ensembl
  7. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Reactome
  8. cellular response to glucagon stimulus Source: Reactome
  9. energy reserve metabolic process Source: Reactome
  10. epidermal growth factor receptor signaling pathway Source: Reactome
  11. fibroblast growth factor receptor signaling pathway Source: Reactome
  12. innate immune response Source: Reactome
  13. intracellular signal transduction Source: InterPro
  14. locomotory behavior Source: Ensembl
  15. neuromuscular process controlling balance Source: Ensembl
  16. neurotrophin TRK receptor signaling pathway Source: Reactome
  17. signal transduction Source: Reactome
  18. small molecule metabolic process Source: Reactome
  19. synaptic transmission Source: Reactome
  20. transmembrane transport Source: Reactome
  21. water transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi4.6.1.1. 2681.
ReactomeiREACT_15312. Adenylate cyclase activating pathway.
REACT_15333. Adenylate cyclase inhibitory pathway.
REACT_15530. PKA activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_19231. G alpha (i) signalling events.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_1946. PKA activation in glucagon signalling.
REACT_24023. Regulation of water balance by renal Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 5 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 5
Adenylate cyclase type V
Adenylyl cyclase 5
Gene namesi
Name:ADCY5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:236. ADCY5.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: BHF-UCL
  3. primary cilium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Membrane

Pathology & Biotechi

Involvement in diseasei

Dyskinesia, familial, with facial myokymia (FDFM) [MIM:606703]: A disorder characterized by predominantly perioral and periorbital myokymia, and face, neck and upper limb dystonic/choreic movements. Initially paroxysmal and worsened by stress, the dyskinetic episodes become nearly constant by the end of the third decade of life, but in some individuals, they may diminish in frequency and severity at older ages.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti726 – 7261A → T in FDFM. 1 Publication
VAR_068821

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi606703. phenotype.
Orphaneti324588. Familial dyskinesia and facial myokymia.
PharmGKBiPA24563.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12611261Adenylate cyclase type 5PRO_0000195694Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi870 – 8701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi887 – 8871N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylated by RAF1.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO95622.
PRIDEiO95622.

PTM databases

PhosphoSiteiO95622.

Expressioni

Gene expression databases

BgeeiO95622.
CleanExiHS_ADCY5.
ExpressionAtlasiO95622. baseline and differential.
GenevestigatoriO95622.

Organism-specific databases

HPAiHPA017730.

Interactioni

Subunit structurei

Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2 By similarity. Interacts with RAF1.By similarity1 Publication

Protein-protein interaction databases

BioGridi106624. 14 interactions.
STRINGi9606.ENSP00000419361.

Structurei

3D structure databases

ProteinModelPortaliO95622.
SMRiO95622. Positions 454-643, 1064-1255.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 195195CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini395 – 769375CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini857 – 90953ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1005 – 1261257CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei196 – 21621HelicalSequence AnalysisAdd
BLAST
Transmembranei242 – 26221HelicalSequence AnalysisAdd
BLAST
Transmembranei268 – 28821HelicalSequence AnalysisAdd
BLAST
Transmembranei299 – 31921HelicalSequence AnalysisAdd
BLAST
Transmembranei325 – 34521HelicalSequence AnalysisAdd
BLAST
Transmembranei374 – 39421HelicalSequence AnalysisAdd
BLAST
Transmembranei770 – 79021HelicalSequence AnalysisAdd
BLAST
Transmembranei792 – 81221HelicalSequence AnalysisAdd
BLAST
Transmembranei836 – 85621HelicalSequence AnalysisAdd
BLAST
Transmembranei910 – 93021HelicalSequence AnalysisAdd
BLAST
Transmembranei935 – 95521HelicalSequence AnalysisAdd
BLAST
Transmembranei984 – 100421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini469 – 596128Guanylate cyclase 1PROSITE-ProRule annotationAdd
BLAST
Domaini1071 – 1210140Guanylate cyclase 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00760000119042.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
InParanoidiO95622.
KOiK08045.
OMAiVRSKMNS.
OrthoDBiEOG7B8S30.
PhylomeDBiO95622.
TreeFamiTF313845.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95622-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGSKSVSPP GYAAQKTAAP APRGGPEHRS AWGEADSRAN GYPHAPGGSA
60 70 80 90 100
RGSTKKPGGA VTPQQQQRLA SRWRSDDDDD PPLSGDDPLA GGFGFSFRSK
110 120 130 140 150
SAWQERGGDD CGRGSRRQRR GAASGGSTRA PPAGGGGGSA AAAASAGGTE
160 170 180 190 200
VRPRSVEVGL EERRGKGRAA DELEAGAVEG GEGSGDGGSS ADSGSGAGPG
210 220 230 240 250
AVLSLGACCL ALLQIFRSKK FPSDKLERLY QRYFFRLNQS SLTMLMAVLV
260 270 280 290 300
LVCLVMLAFH AARPPLQLPY LAVLAAAVGV ILIMAVLCNR AAFHQDHMGL
310 320 330 340 350
ACYALIAVVL AVQVVGLLLP QPRSASEGIW WTVFFIYTIY TLLPVRMRAA
360 370 380 390 400
VLSGVLLSAL HLAIALRTNA QDQFLLKQLV SNVLIFSCTN IVGVCTHYPA
410 420 430 440 450
EVSQRQAFQE TRECIQARLH SQRENQQQER LLLSVLPRHV AMEMKADINA
460 470 480 490 500
KQEDMMFHKI YIQKHDNVSI LFADIEGFTS LASQCTAQEL VMTLNELFAR
510 520 530 540 550
FDKLAAENHC LRIKILGDCY YCVSGLPEAR ADHAHCCVEM GMDMIEAISL
560 570 580 590 600
VREVTGVNVN MRVGIHSGRV HCGVLGLRKW QFDVWSNDVT LANHMEAGGK
610 620 630 640 650
AGRIHITKAT LNYLNGDYEV EPGCGGERNA YLKEHSIETF LILRCTQKRK
660 670 680 690 700
EEKAMIAKMN RQRTNSIGHN PPHWGAERPF YNHLGGNQVS KEMKRMGFED
710 720 730 740 750
PKDKNAQESA NPEDEVDEFL GRAIDARSID RLRSEHVRKF LLTFREPDLE
760 770 780 790 800
KKYSKQVDDR FGAYVACASL VFLFICFVQI TIVPHSIFML SFYLTCSLLL
810 820 830 840 850
TLVVFVSVIY SCVKLFPSPL QTLSRKIVRS KMNSTLVGVF TITLVFLAAF
860 870 880 890 900
VNMFTCNSRD LLGCLAQEHN ISASQVNACH VAESAVNYSL GDEQGFCGSP
910 920 930 940 950
WPNCNFPEYF TYSVLLSLLA CSVFLQISCI GKLVLMLAIE LIYVLIVEVP
960 970 980 990 1000
GVTLFDNADL LVTANAIDFF NNGTSQCPEH ATKVALKVVT PIIISVFVLA
1010 1020 1030 1040 1050
LYLHAQQVES TARLDFLWKL QATEEKEEME ELQAYNRRLL HNILPKDVAA
1060 1070 1080 1090 1100
HFLARERRND ELYYQSCECV AVMFASIANF SEFYVELEAN NEGVECLRLL
1110 1120 1130 1140 1150
NEIIADFDEI ISEDRFRQLE KIKTIGSTYM AASGLNDSTY DKVGKTHIKA
1160 1170 1180 1190 1200
LADFAMKLMD QMKYINEHSF NNFQMKIGLN IGPVVAGVIG ARKPQYDIWG
1210 1220 1230 1240 1250
NTVNVASRMD STGVPDRIQV TTDMYQVLAA NTYQLECRGV VKVKGKGEMM
1260
TYFLNGGPPL S
Length:1,261
Mass (Da):138,908
Last modified:November 28, 2006 - v3
Checksum:iC50492A0B053694F
GO
Isoform 2 (identifier: O95622-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MSGSKSVSPPGYAAQKTAAPAPRGGPEH → MKSQKEGCCSRGDLSIQTGPGGEWAPRR
     29-378: Missing.

Note: No experimental confirmation available.

Show »
Length:911
Mass (Da):102,606
Checksum:iCA9E766B744A6222
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti726 – 7261A → T in FDFM. 1 Publication
VAR_068821

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2828MSGSK…GGPEH → MKSQKEGCCSRGDLSIQTGP GGEWAPRR in isoform 2. 1 PublicationVSP_042914Add
BLAST
Alternative sequencei29 – 378350Missing in isoform 2. 1 PublicationVSP_042915Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK303070 mRNA. Translation: BAH13892.1.
AC025571 Genomic DNA. No translation available.
AC112503 Genomic DNA. No translation available.
AF497517 mRNA. Translation: AAM94374.1.
U65473 mRNA. Translation: AAD00121.1.
BK000371 mRNA. Translation: DAA00057.1.
CCDSiCCDS3022.1. [O95622-1]
CCDS56274.1. [O95622-2]
RefSeqiNP_001186571.1. NM_001199642.1. [O95622-2]
NP_899200.1. NM_183357.2. [O95622-1]
UniGeneiHs.593292.

Genome annotation databases

EnsembliENST00000309879; ENSP00000308685; ENSG00000173175. [O95622-2]
ENST00000462833; ENSP00000419361; ENSG00000173175. [O95622-1]
GeneIDi111.
KEGGihsa:111.
UCSCiuc003egh.2. human. [O95622-1]
uc003egi.1. human. [O95622-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK303070 mRNA. Translation: BAH13892.1 .
AC025571 Genomic DNA. No translation available.
AC112503 Genomic DNA. No translation available.
AF497517 mRNA. Translation: AAM94374.1 .
U65473 mRNA. Translation: AAD00121.1 .
BK000371 mRNA. Translation: DAA00057.1 .
CCDSi CCDS3022.1. [O95622-1 ]
CCDS56274.1. [O95622-2 ]
RefSeqi NP_001186571.1. NM_001199642.1. [O95622-2 ]
NP_899200.1. NM_183357.2. [O95622-1 ]
UniGenei Hs.593292.

3D structure databases

ProteinModelPortali O95622.
SMRi O95622. Positions 454-643, 1064-1255.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106624. 14 interactions.
STRINGi 9606.ENSP00000419361.

Chemistry

BindingDBi O95622.
ChEMBLi CHEMBL2097167.
GuidetoPHARMACOLOGYi 1282.

PTM databases

PhosphoSitei O95622.

Proteomic databases

PaxDbi O95622.
PRIDEi O95622.

Protocols and materials databases

DNASUi 111.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309879 ; ENSP00000308685 ; ENSG00000173175 . [O95622-2 ]
ENST00000462833 ; ENSP00000419361 ; ENSG00000173175 . [O95622-1 ]
GeneIDi 111.
KEGGi hsa:111.
UCSCi uc003egh.2. human. [O95622-1 ]
uc003egi.1. human. [O95622-2 ]

Organism-specific databases

CTDi 111.
GeneCardsi GC03M122949.
H-InvDB HIX0003612.
HGNCi HGNC:236. ADCY5.
HPAi HPA017730.
MIMi 600293. gene.
606703. phenotype.
neXtProti NX_O95622.
Orphaneti 324588. Familial dyskinesia and facial myokymia.
PharmGKBi PA24563.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2114.
GeneTreei ENSGT00760000119042.
HOGENOMi HOG000006941.
HOVERGENi HBG050458.
InParanoidi O95622.
KOi K08045.
OMAi VRSKMNS.
OrthoDBi EOG7B8S30.
PhylomeDBi O95622.
TreeFami TF313845.

Enzyme and pathway databases

BRENDAi 4.6.1.1. 2681.
Reactomei REACT_15312. Adenylate cyclase activating pathway.
REACT_15333. Adenylate cyclase inhibitory pathway.
REACT_15530. PKA activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_19231. G alpha (i) signalling events.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_1946. PKA activation in glucagon signalling.
REACT_24023. Regulation of water balance by renal Aquaporins.

Miscellaneous databases

ChiTaRSi ADCY5. human.
GeneWikii ADCY5.
GenomeRNAii 111.
NextBioi 427.
PROi O95622.
SOURCEi Search...

Gene expression databases

Bgeei O95622.
CleanExi HS_ADCY5.
ExpressionAtlasi O95622. baseline and differential.
Genevestigatori O95622.

Family and domain databases

Gene3Di 3.30.70.1230. 2 hits.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
IPR029787. Nucleotide_cyclase.
[Graphical view ]
Pfami PF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view ]
SMARTi SM00044. CYCc. 2 hits.
[Graphical view ]
SUPFAMi SSF55073. SSF55073. 2 hits.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms."
    Ludwig M.G., Seuwen K.
    J. Recept. Signal Transduct. 22:79-110(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 368-1261 (ISOFORM 1).
    Tissue: Heart.
  4. "Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues."
    Raimundo S., Giray J., Volff J.-N., Schwab M., Altenbuchner J., Ratge D., Wisser H.
    Clin. Chim. Acta 285:155-161(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 560-664 (ISOFORM 1).
    Tissue: Heart muscle.
  5. "Raf kinase activation of adenylyl cyclases: isoform-selective regulation."
    Ding Q., Gros R., Gray I.D., Taussig R., Ferguson S.S., Feldman R.D.
    Mol. Pharmacol. 66:921-928(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY RAF1, INTERACTION WITH RAF1, ENZYME REGULATION.
  6. "Autosomal dominant familial dyskinesia and facial myokymia: single exome sequencing identifies a mutation in adenylyl cyclase 5."
    Chen Y.Z., Matsushita M.M., Robertson P., Rieder M., Girirajan S., Antonacci F., Lipe H., Eichler E.E., Nickerson D.A., Bird T.D., Raskind W.H.
    Arch. Neurol. 69:630-635(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT FDFM THR-726.

Entry informationi

Entry nameiADCY5_HUMAN
AccessioniPrimary (citable) accession number: O95622
Secondary accession number(s): B7Z8A6, Q7RTV7, Q8NFM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 28, 2006
Last modified: October 29, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3