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Protein

YEATS domain-containing protein 4

Gene

YEATS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.1 Publication

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • protein C-terminus binding Source: UniProtKB
  • structural constituent of cytoskeleton Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • histone H2A acetylation Source: UniProtKB
  • histone H4 acetylation Source: UniProtKB
  • mitotic cell cycle Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: Reactome
  • regulation of growth Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator
Biological processGrowth regulation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214847. HATs acetylate histones.
R-HSA-8866907. Activation of the TFAP2 (AP-2) family of transcription factors.

Names & Taxonomyi

Protein namesi
Recommended name:
YEATS domain-containing protein 4
Alternative name(s):
Glioma-amplified sequence 41
Short name:
Gas41
NuMA-binding protein 1
Short name:
NuBI-1
Short name:
NuBI1
Gene namesi
Name:YEATS4
Synonyms:GAS41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000127337.6.
HGNCiHGNC:24859. YEATS4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8089.
OpenTargetsiENSG00000127337.
PharmGKBiPA134992686.

Polymorphism and mutation databases

BioMutaiYEATS4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000662041 – 227YEATS domain-containing protein 4Add BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki37Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiO95619.
MaxQBiO95619.
PaxDbiO95619.
PeptideAtlasiO95619.
PRIDEiO95619.

PTM databases

iPTMnetiO95619.
PhosphoSitePlusiO95619.

Expressioni

Tissue specificityi

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000127337.
CleanExiHS_YEATS4.
ExpressionAtlasiO95619. baseline and differential.
GenevisibleiO95619. HS.

Organism-specific databases

HPAiHPA072532.

Interactioni

Subunit structurei

Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. YEATS4 interacts with MLLT10/AF10. YEATS4 may also interact with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TACC1O754106EBI-399269,EBI-624237

GO - Molecular functioni

  • protein C-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi113761. 142 interactors.
CORUMiO95619.
IntActiO95619. 65 interactors.
MINTiMINT-3003084.
STRINGi9606.ENSP00000247843.

Structurei

3D structure databases

ProteinModelPortaliO95619.
SMRiO95619.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 126YEATSPROSITE-ProRule annotationAdd BLAST105

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni163 – 227Interaction with MLLT101 PublicationAdd BLAST65
Regioni168 – 227Interaction with TACC11 PublicationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili178 – 226Sequence analysisAdd BLAST49

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3149. Eukaryota.
COG5033. LUCA.
GeneTreeiENSGT00530000063543.
HOGENOMiHOG000190181.
HOVERGENiHBG061271.
InParanoidiO95619.
KOiK11341.
OrthoDBiEOG091G0L66.
PhylomeDBiO95619.

Family and domain databases

InterProiView protein in InterPro
IPR005033. YEATS.
PANTHERiPTHR23195. PTHR23195. 2 hits.
PfamiView protein in Pfam
PF03366. YEATS. 1 hit.
PROSITEiView protein in PROSITE
PS51037. YEATS. 1 hit.

Sequencei

Sequence statusi: Complete.

O95619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKRMAEFGP DSGGRVKGVT IVKPIVYGNV ARYFGKKREE DGHTHQWTVY
60 70 80 90 100
VKPYRNEDMS AYVKKIQFKL HESYGNPLRV VTKPPYEITE TGWGEFEIII
110 120 130 140 150
KIFFIDPNER PVTLYHLLKL FQSDTNAMLG KKTVVSEFYD EMIFQDPTAM
160 170 180 190 200
MQQLLTTSRQ LTLGAYKHET EFAELEVKTR EKLEAAKKKT SFEIAELKER
210 220
LKASRETINC LKNEIRKLEE DDQAKDI
Length:227
Mass (Da):26,499
Last modified:May 1, 1999 - v1
Checksum:i34C4692B227A7B85
GO

Sequence cautioni

The sequence CAC01935 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159R → C in CAC01935 (PubMed:10913114).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61384 mRNA. Translation: AAD12188.1.
AJ245746 mRNA. Translation: CAC01935.1. Different initiation.
AK001413 mRNA. Translation: BAA91678.1.
BC000994 mRNA. Translation: AAH00994.1.
CCDSiCCDS8990.1.
RefSeqiNP_001287879.1. NM_001300950.1.
NP_006521.1. NM_006530.3.
UniGeneiHs.4029.

Genome annotation databases

EnsembliENST00000247843; ENSP00000247843; ENSG00000127337.
GeneIDi8089.
KEGGihsa:8089.
UCSCiuc001sux.4. human.

Similar proteinsi

Entry informationi

Entry nameiYETS4_HUMAN
AccessioniPrimary (citable) accession number: O95619
Secondary accession number(s): Q9NQD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 1999
Last modified: October 25, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot