O95619 (YETS4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
YEATS domain-containing protein 4

Alternative name(s):
Glioma-amplified sequence 41
Short name=Gas41
NuMA-binding protein 1
Short name=NuBI-1
Short name=NuBI1

Gene names

Name:	YEATS4
Synonyms:	GAS41

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Ref.10
Subunit structure	Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. YEATS4 interacts with MLLT10/AF10. YEATS4 may also interact with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1. Ref.2 Ref.5 Ref.6 Ref.7 Ref.8 Ref.10
Subcellular location	Nucleus Ref.2.
Tissue specificity	Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. Ref.2
Sequence similarities	Contains 1 YEATS domain.
Sequence caution	The sequence CAC01935.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Growth regulation Transcription Transcription regulation
Cellular component	Nucleus
Domain	Coiled coil
Molecular function	Chromatin regulator
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	histone H2A acetylation Inferred from direct assay Ref.10. Source: UniProtKB histone H4 acetylation Inferred from direct assay Ref.10. Source: UniProtKB mitosis Non-traceable author statement Ref.2. Source: UniProtKB positive regulation of transcription, DNA-dependent Non-traceable author statement Ref.2. Source: UniProtKB regulation of growth Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	NuA4 histone acetyltransferase complex Inferred from direct assay Ref.10. Source: UniProtKB nuclear matrix Non-traceable author statement Ref.2. Source: UniProtKB
Molecular_function	DNA binding Traceable author statement Ref.1. Source: ProtInc sequence-specific DNA binding transcription factor activity Traceable author statement Ref.1. Source: ProtInc structural constituent of cytoskeleton Non-traceable author statement Ref.2. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TACC1	O75410	6	EBI-399269,EBI-624237

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	YEATS domain-containing protein 4		PRO_0000066204
Regions
	Domain	22 – 126	105	YEATS
	Region	163 – 227	65	Interaction with MLLT10
	Region	168 – 227	60	Interaction with TACC1
	Coiled coil	178 – 226	49	Potential
Experimental info
	Sequence conflict	159	1	R → C in CAC01935. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O95619 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 34C4692B227A7B85	FASTA	227	26,499
	10 20 30 40 50 60 MFKRMAEFGP DSGGRVKGVT IVKPIVYGNV ARYFGKKREE DGHTHQWTVY VKPYRNEDMS 70 80 90 100 110 120 AYVKKIQFKL HESYGNPLRV VTKPPYEITE TGWGEFEIII KIFFIDPNER PVTLYHLLKL 130 140 150 160 170 180 FQSDTNAMLG KKTVVSEFYD EMIFQDPTAM MQQLLTTSRQ LTLGAYKHET EFAELEVKTR 190 200 210 220 EKLEAAKKKT SFEIAELKER LKASRETINC LKNEIRKLEE DDQAKDI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a novel transcription factor-like gene amplified in human glioma including astrocytoma grade I." Fischer U., Heckel D., Michel A., Janka M., Hulsebos T., Meese E. Hum. Mol. Genet. 6:1817-1822(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA." Harborth J., Weber K., Osborn M. J. Biol. Chem. 275:31979-31985(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH NUMA1, TISSUE SPECIFICITY.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex." Cai Y., Jin J., Tomomori-Sato C., Sato S., Sorokina I., Parmely T.J., Conaway R.C., Conaway J.W. J. Biol. Chem. 278:42733-42736(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 5-15; 18-32; 56-64; 120-131; 168-178 AND 217-227, IDENTIFICATION IN NUA4 COMPLEX, MASS SPECTROMETRY.
[6]	"Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells." Lauffart B., Howell S.J., Tasch J.E., Cowell J.K., Still I.H. Biochem. J. 363:195-200(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TACC1.
[7]	"The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex." Debernardi S., Bassini A., Jones L.K., Chaplin T., Linder B., de Bruijn D.R.H., Meese E., Young B.D. Blood 99:275-281(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MLLT10 AND SMARCB1.
[8]	"Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2." Lauffart B., Gangisetty O., Still I.H. Genomics 81:192-201(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TACC2.
[9]	"The highly conserved and multifunctional NuA4 HAT complex." Doyon Y., Cote J. Curr. Opin. Genet. Dev. 14:147-154(2004) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW ON NUA4 COMPLEX.
[10]	"Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans." Doyon Y., Selleck W., Lane W.S., Tan S., Cote J. Mol. Cell. Biol. 24:1884-1896(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN NUA4 COMPLEX, IDENTIFICATION IN NUA4-RELATED SRCAP-CONTAINING COMPLEX.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U61384 mRNA. Translation: AAD12188.1. AJ245746 mRNA. Translation: CAC01935.1. Different initiation. AK001413 mRNA. Translation: BAA91678.1. BC000994 mRNA. Translation: AAH00994.1.
IPI	IPI00008536.
RefSeq	NP_006521.1. NM_006530.2.
UniGene	Hs.4029.
3D structure databases
ProteinModelPortal	O95619.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95619. 9 interactions.
STRING	9606.ENSP00000247843.
PTM databases
PhosphoSite	O95619.
Proteomic databases
PaxDb	O95619.
PeptideAtlas	O95619.
PRIDE	O95619.
Protocols and materials databases
DNASU	8089.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000247843; ENSP00000247843; ENSG00000127337.
GeneID	8089.
KEGG	hsa:8089.
UCSC	uc001sux.3. human.
Organism-specific databases
CTD	8089.
GeneCards	GC12P069753.
HGNC	HGNC:24859. YEATS4.
MIM	602116. gene.
neXtProt	NX_O95619.
PharmGKB	PA134992686.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5033.
HOGENOM	HOG000190181.
HOVERGEN	HBG061271.
InParanoid	O95619.
KO	K11341.
OrthoDB	EOG40P47R.
PhylomeDB	O95619.
Gene expression databases
ArrayExpress	O95619.
Bgee	O95619.
CleanEx	HS_YEATS4.
Genevestigator	O95619.
GermOnline	ENSG00000127337. Homo sapiens.
Family and domain databases
InterPro	IPR005033. YEATS. [Graphical view]
PANTHER	PTHR23195. PTHR23195. 1 hit.
Pfam	PF03366. YEATS. 1 hit. [Graphical view]
PROSITE	PS51037. YEATS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	8089.
NextBio	30722.
SOURCE	Search...

Entry information

Entry name

YETS4_HUMAN

Accession

Primary (citable) accession number: O95619
Secondary accession number(s): Q9NQD0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.