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Protein

YEATS domain-containing protein 4

Gene

YEATS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.1 Publication

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • DNA binding transcription factor activity Source: ProtInc
  • protein C-terminus binding Source: UniProtKB
  • structural constituent of cytoskeleton Source: UniProtKB

GO - Biological processi

  • histone H2A acetylation Source: UniProtKB
  • histone H4 acetylation Source: UniProtKB
  • mitotic cell cycle Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: Reactome
  • regulation of growth Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator
Biological processGrowth regulation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Names & Taxonomyi

Protein namesi
Recommended name:
YEATS domain-containing protein 4
Alternative name(s):
Glioma-amplified sequence 41
Short name:
Gas41
NuMA-binding protein 1
Short name:
NuBI-1
Short name:
NuBI1
Gene namesi
Name:YEATS4
Synonyms:GAS41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000127337.6
HGNCiHGNC:24859 YEATS4
MIMi602116 gene
neXtProtiNX_O95619

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8089
OpenTargetsiENSG00000127337
PharmGKBiPA134992686

Polymorphism and mutation databases

BioMutaiYEATS4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000662041 – 227YEATS domain-containing protein 4Add BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki37Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiO95619
MaxQBiO95619
PaxDbiO95619
PeptideAtlasiO95619
PRIDEiO95619

PTM databases

iPTMnetiO95619
PhosphoSitePlusiO95619

Expressioni

Tissue specificityi

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000127337
CleanExiHS_YEATS4
ExpressionAtlasiO95619 baseline and differential
GenevisibleiO95619 HS

Organism-specific databases

HPAiHPA072532

Interactioni

Subunit structurei

Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. YEATS4 interacts with MLLT10/AF10. YEATS4 may also interact with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TACC1O754106EBI-399269,EBI-624237

GO - Molecular functioni

  • protein C-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi113761, 142 interactors
CORUMiO95619
IntActiO95619, 65 interactors
MINTiO95619
STRINGi9606.ENSP00000247843

Structurei

3D structure databases

ProteinModelPortaliO95619
SMRiO95619
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 126YEATSPROSITE-ProRule annotationAdd BLAST105

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni163 – 227Interaction with MLLT101 PublicationAdd BLAST65
Regioni168 – 227Interaction with TACC11 PublicationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili178 – 226Sequence analysisAdd BLAST49

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3149 Eukaryota
COG5033 LUCA
GeneTreeiENSGT00530000063543
HOGENOMiHOG000190181
HOVERGENiHBG061271
InParanoidiO95619
KOiK11341
OrthoDBiEOG091G0L66
PhylomeDBiO95619

Family and domain databases

Gene3Di2.60.40.1970, 1 hit
InterProiView protein in InterPro
IPR037989 Yaf9/YEATS4
IPR038704 YEAST_sf
IPR005033 YEATS
PANTHERiPTHR23195 PTHR23195, 2 hits
PTHR23195:SF15 PTHR23195:SF15, 2 hits
PfamiView protein in Pfam
PF03366 YEATS, 1 hit
PROSITEiView protein in PROSITE
PS51037 YEATS, 1 hit

Sequencei

Sequence statusi: Complete.

O95619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKRMAEFGP DSGGRVKGVT IVKPIVYGNV ARYFGKKREE DGHTHQWTVY
60 70 80 90 100
VKPYRNEDMS AYVKKIQFKL HESYGNPLRV VTKPPYEITE TGWGEFEIII
110 120 130 140 150
KIFFIDPNER PVTLYHLLKL FQSDTNAMLG KKTVVSEFYD EMIFQDPTAM
160 170 180 190 200
MQQLLTTSRQ LTLGAYKHET EFAELEVKTR EKLEAAKKKT SFEIAELKER
210 220
LKASRETINC LKNEIRKLEE DDQAKDI
Length:227
Mass (Da):26,499
Last modified:May 1, 1999 - v1
Checksum:i34C4692B227A7B85
GO

Sequence cautioni

The sequence CAC01935 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159R → C in CAC01935 (PubMed:10913114).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61384 mRNA Translation: AAD12188.1
AJ245746 mRNA Translation: CAC01935.1 Different initiation.
AK001413 mRNA Translation: BAA91678.1
BC000994 mRNA Translation: AAH00994.1
CCDSiCCDS8990.1
RefSeqiNP_001287879.1, NM_001300950.1
NP_006521.1, NM_006530.3
UniGeneiHs.4029

Genome annotation databases

EnsembliENST00000247843; ENSP00000247843; ENSG00000127337
GeneIDi8089
KEGGihsa:8089
UCSCiuc001sux.4 human

Similar proteinsi

Entry informationi

Entry nameiYETS4_HUMAN
AccessioniPrimary (citable) accession number: O95619
Secondary accession number(s): Q9NQD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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