##gff-version 3 O95613 UniProtKB Chain 1 3336 . . . ID=PRO_0000058257;Note=Pericentrin O95613 UniProtKB Region 1 71 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95613 UniProtKB Region 81 100 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95613 UniProtKB Region 569 589 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95613 UniProtKB Region 1619 1638 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95613 UniProtKB Region 1954 1974 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95613 UniProtKB Region 2168 2214 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95613 UniProtKB Region 2318 2374 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95613 UniProtKB Region 2875 2910 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95613 UniProtKB Region 2983 3246 . . . Note=Interaction with NEK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20599736;Dbxref=PMID:20599736 O95613 UniProtKB Region 3084 3126 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95613 UniProtKB Region 3195 3208 . . . Note=Calmodulin-binding O95613 UniProtKB Region 3224 3300 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95613 UniProtKB Coiled coil 258 553 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 O95613 UniProtKB Coiled coil 675 835 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 O95613 UniProtKB Coiled coil 1010 1146 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 O95613 UniProtKB Coiled coil 1299 1949 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 O95613 UniProtKB Coiled coil 2064 2082 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 O95613 UniProtKB Coiled coil 2536 3086 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 O95613 UniProtKB Compositional bias 1 47 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95613 UniProtKB Compositional bias 2182 2202 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95613 UniProtKB Compositional bias 2875 2895 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95613 UniProtKB Compositional bias 3084 3099 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95613 UniProtKB Compositional bias 3236 3250 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95613 UniProtKB Compositional bias 3252 3266 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95613 UniProtKB Compositional bias 3279 3300 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95613 UniProtKB Modified residue 44 44 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O95613 UniProtKB Modified residue 188 188 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O95613 UniProtKB Modified residue 191 191 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 O95613 UniProtKB Modified residue 610 610 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 O95613 UniProtKB Modified residue 682 682 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 O95613 UniProtKB Modified residue 1245 1245 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O95613 UniProtKB Modified residue 1653 1653 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O95613 UniProtKB Modified residue 1712 1712 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P48725 O95613 UniProtKB Modified residue 2044 2044 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 O95613 UniProtKB Modified residue 2177 2177 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 O95613 UniProtKB Modified residue 2192 2192 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O95613 UniProtKB Modified residue 2225 2225 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P48725 O95613 UniProtKB Modified residue 2226 2226 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P48725 O95613 UniProtKB Modified residue 2327 2327 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 O95613 UniProtKB Modified residue 2352 2352 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O95613 UniProtKB Modified residue 2355 2355 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O95613 UniProtKB Modified residue 2477 2477 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 O95613 UniProtKB Modified residue 2486 2486 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 O95613 UniProtKB Modified residue 3302 3302 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 O95613 UniProtKB Alternative sequence 1 118 . . . ID=VSP_040104;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9455477;Dbxref=PMID:9455477 O95613 UniProtKB Alternative sequence 2839 2917 . . . ID=VSP_040105;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9455477;Dbxref=PMID:9455477 O95613 UniProtKB Natural variant 539 539 . . . ID=VAR_043878;Note=T->I;Dbxref=dbSNP:rs2249060 O95613 UniProtKB Natural variant 704 704 . . . ID=VAR_043879;Note=G->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11171385,ECO:0000269|PubMed:9455477,ECO:0000269|Ref.2;Dbxref=dbSNP:rs2839223,PMID:11171385,PMID:9455477 O95613 UniProtKB Natural variant 879 879 . . . ID=VAR_043880;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11171385;Dbxref=dbSNP:rs2839227,PMID:11171385 O95613 UniProtKB Natural variant 1038 1038 . . . ID=VAR_043881;Note=V->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11171385,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:9455477;Dbxref=dbSNP:rs6518289,PMID:11171385,PMID:14702039,PMID:9455477 O95613 UniProtKB Natural variant 1163 1163 . . . ID=VAR_043882;Note=R->C;Dbxref=dbSNP:rs7279204 O95613 UniProtKB Natural variant 1194 1194 . . . ID=VAR_043883;Note=A->T;Dbxref=dbSNP:rs35044802 O95613 UniProtKB Natural variant 1452 1452 . . . ID=VAR_069420;Note=Found in a patient with intellectual disability%2C no speech%2C facial and limbs dysmorphisms. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23033978;Dbxref=dbSNP:rs143796569,PMID:23033978 O95613 UniProtKB Natural variant 1639 1639 . . . ID=VAR_043884;Note=I->V;Dbxref=dbSNP:rs6518291 O95613 UniProtKB Natural variant 1841 1841 . . . ID=VAR_043885;Note=N->S;Dbxref=dbSNP:rs35940413 O95613 UniProtKB Natural variant 1953 1953 . . . ID=VAR_043886;Note=R->H;Dbxref=dbSNP:rs34268261 O95613 UniProtKB Natural variant 1960 1960 . . . ID=VAR_043887;Note=R->Q;Dbxref=dbSNP:rs34813667 O95613 UniProtKB Natural variant 2097 2097 . . . ID=VAR_043888;Note=L->P;Dbxref=dbSNP:rs2839245 O95613 UniProtKB Natural variant 2125 2125 . . . ID=VAR_043889;Note=H->P;Dbxref=dbSNP:rs35978208 O95613 UniProtKB Natural variant 2188 2188 . . . ID=VAR_043890;Note=M->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11171385;Dbxref=dbSNP:rs1044998,PMID:11171385 O95613 UniProtKB Natural variant 2191 2191 . . . ID=VAR_043891;Note=S->P;Dbxref=dbSNP:rs34151633 O95613 UniProtKB Natural variant 2239 2239 . . . ID=VAR_056961;Note=W->R;Dbxref=dbSNP:rs35346764 O95613 UniProtKB Natural variant 2274 2274 . . . ID=VAR_056962;Note=P->L;Dbxref=dbSNP:rs2070425 O95613 UniProtKB Natural variant 2329 2329 . . . ID=VAR_056963;Note=P->R;Dbxref=dbSNP:rs35848602 O95613 UniProtKB Natural variant 2361 2361 . . . ID=VAR_056964;Note=Q->R;Dbxref=dbSNP:rs7277175 O95613 UniProtKB Natural variant 2424 2424 . . . ID=VAR_069421;Note=Found in a patient with intellectual disability%2C no speech%2C facial and limbs dysmorphisms. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23033978;Dbxref=dbSNP:rs371893416,PMID:23033978 O95613 UniProtKB Natural variant 2549 2549 . . . ID=VAR_056965;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11171385;Dbxref=dbSNP:rs2839256,PMID:11171385 O95613 UniProtKB Natural variant 2625 2625 . . . ID=VAR_056966;Note=R->Q;Dbxref=dbSNP:rs8131693 O95613 UniProtKB Natural variant 2659 2659 . . . ID=VAR_056967;Note=Q->H;Dbxref=dbSNP:rs2070426 O95613 UniProtKB Natural variant 2753 2753 . . . ID=VAR_056968;Note=R->H;Dbxref=dbSNP:rs743346 O95613 UniProtKB Natural variant 2792 2792 . . . ID=VAR_056969;Note=Q->R;Dbxref=dbSNP:rs2073376 O95613 UniProtKB Natural variant 2903 2903 . . . ID=VAR_056970;Note=A->T;Dbxref=dbSNP:rs35147998 O95613 UniProtKB Natural variant 2975 2975 . . . ID=VAR_056971;Note=L->P;Dbxref=dbSNP:rs35881595 O95613 UniProtKB Natural variant 3091 3091 . . . ID=VAR_056972;Note=S->G;Dbxref=dbSNP:rs4818842 O95613 UniProtKB Natural variant 3245 3245 . . . ID=VAR_056973;Note=R->S;Dbxref=dbSNP:rs2073380 O95613 UniProtKB Mutagenesis 2231 2231 . . . Note=Produces non-cleavable protein which remains on centrosomes in late mitosis until its levels eventually drop in cells undergoing cytokinesis. R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22722493,ECO:0000269|PubMed:25503564;Dbxref=PMID:22722493,PMID:25503564 O95613 UniProtKB Mutagenesis 2232 2232 . . . Note=Stabilizes the C-terminal fragment produced by cleavage. K->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22722493;Dbxref=PMID:22722493 O95613 UniProtKB Mutagenesis 3196 3197 . . . Note=Decrease in calmodulin binding. FR->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10823944;Dbxref=PMID:10823944 O95613 UniProtKB Mutagenesis 3203 3203 . . . Note=Decrease in calmodulin binding. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10823944;Dbxref=PMID:10823944 O95613 UniProtKB Mutagenesis 3208 3209 . . . Note=Decrease in calmodulin binding. RL->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10823944;Dbxref=PMID:10823944 O95613 UniProtKB Sequence conflict 703 703 . . . Note=Y->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 O95613 UniProtKB Sequence conflict 789 789 . . . Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 O95613 UniProtKB Sequence conflict 819 819 . . . Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 O95613 UniProtKB Sequence conflict 890 900 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 O95613 UniProtKB Sequence conflict 967 967 . . . Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 O95613 UniProtKB Sequence conflict 1024 1024 . . . Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 O95613 UniProtKB Sequence conflict 1036 1036 . . . Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 O95613 UniProtKB Sequence conflict 1287 1287 . . . Note=I->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 O95613 UniProtKB Sequence conflict 1317 1317 . . . Note=K->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 O95613 UniProtKB Sequence conflict 1534 1534 . . . Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 O95613 UniProtKB Sequence conflict 3136 3136 . . . Note=Y->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 O95613 UniProtKB Sequence conflict 3300 3300 . . . Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305