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Protein

Pericentrin

Gene

PCNT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome.4 Publications

GO - Biological processi

  • cilium assembly Source: MGI
  • G2/M transition of mitotic cell cycle Source: Reactome
  • microtubule cytoskeleton organization Source: UniProtKB
  • mitotic spindle organization Source: GO_Central
  • positive regulation of intracellular protein transport Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160299-MONOMER.
ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.
SIGNORiO95613.

Names & Taxonomyi

Protein namesi
Recommended name:
Pericentrin
Alternative name(s):
Kendrin
Pericentrin-B
Gene namesi
Name:PCNT
Synonyms:KIAA0402, PCNT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:16068. PCNT.

Subcellular locationi

GO - Cellular componenti

  • centriolar satellite Source: UniProtKB
  • centriole Source: MGI
  • centrosome Source: UniProtKB
  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • membrane Source: UniProtKB
  • microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Involvement in diseasei

Microcephalic osteodysplastic primordial dwarfism 2 (MOPD2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAdults with this rare inherited condition have an average height of 100 centimeters and a brain size comparable to that of a 3-month-old baby, but are of near-normal intelligence.
See also OMIM:210720

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2231R → A: Produces non-cleavable protein which remains on centrosomes in late mitosis until its levels eventually drop in cells undergoing cytokinesis. 2 Publications1
Mutagenesisi2232K → M: Stabilizes the C-terminal fragment produced by cleavage. 1 Publication1
Mutagenesisi3196 – 3197FR → AA: Decrease in calmodulin binding. 1 Publication2
Mutagenesisi3203V → A: Decrease in calmodulin binding. 1 Publication1
Mutagenesisi3208 – 3209RL → AA: Decrease in calmodulin binding. 1 Publication2

Keywords - Diseasei

Dwarfism

Organism-specific databases

DisGeNETi5116.
MalaCardsiPCNT.
MIMi210720. phenotype.
OpenTargetsiENSG00000160299.
Orphaneti2637. Microcephalic osteodysplastic primordial dwarfism type II.
808. Seckel syndrome.
PharmGKBiPA33079.

Polymorphism and mutation databases

BioMutaiPCNT.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000582571 – 3336PericentrinAdd BLAST3336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineCombined sources1
Modified residuei188PhosphoserineCombined sources1
Modified residuei191PhosphothreonineCombined sources1
Modified residuei610PhosphoserineCombined sources1
Modified residuei682PhosphoserineCombined sources1
Modified residuei1245PhosphoserineCombined sources1
Modified residuei1653PhosphoserineCombined sources1
Modified residuei1712PhosphoserineBy similarity1
Modified residuei2044PhosphoserineCombined sources1
Modified residuei2177PhosphoserineCombined sources1
Modified residuei2192PhosphoserineCombined sources1
Modified residuei2225PhosphoserineBy similarity1
Modified residuei2226PhosphoserineBy similarity1
Modified residuei2327PhosphoserineCombined sources1
Modified residuei2352PhosphoserineCombined sources1
Modified residuei2355PhosphoserineCombined sources1
Modified residuei2477PhosphoserineCombined sources1
Modified residuei2486PhosphoserineCombined sources1
Modified residuei3302PhosphoserineCombined sources1

Post-translational modificationi

Cleaved during mitotis which leads to removal of CDK5RAP2 from the centrosome and promotes centriole disengagement and subsequent centriole separation (PubMed:22722493, PubMed:25503564). The C-terminal fragment is rapidly degraded following cleavage (PubMed:22722493).2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95613.
MaxQBiO95613.
PaxDbiO95613.
PeptideAtlasiO95613.
PRIDEiO95613.

PTM databases

iPTMnetiO95613.
PhosphoSitePlusiO95613.

Expressioni

Tissue specificityi

Expressed in all tissues tested, including placenta, liver, kidney and thymus.1 Publication

Gene expression databases

BgeeiENSG00000160299.
CleanExiHS_PCNT.
ExpressionAtlasiO95613. baseline and differential.
GenevisibleiO95613. HS.

Organism-specific databases

HPAiHPA016820.
HPA019887.
HPA032101.

Interactioni

Subunit structurei

Interacts with CHD3. Interacts with CHD4; the interaction regulates centrosome integrity (By similarity). Interacts with DISC1 and PCM1. Binds calmodulin. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of PCNT and CDK5RAP2. Interacts with isoform 1 of NEK2. Interacts with CEP131. Interacts with CCDC13 (PubMed:24816561). Interacts with CEP68 (PubMed:25503564). Interacts with ATF5; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome (PubMed:26213385).By similarity8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DISC1Q9NRI55EBI-530012,EBI-529989
PCM1Q151547EBI-530012,EBI-741421

Protein-protein interaction databases

BioGridi111146. 68 interactors.
DIPiDIP-33829N.
IntActiO95613. 40 interactors.
MINTiMINT-4527763.
STRINGi9606.ENSP00000352572.

Structurei

3D structure databases

ProteinModelPortaliO95613.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2983 – 3246Interaction with NEK21 PublicationAdd BLAST264
Regioni3195 – 3208Calmodulin-bindingAdd BLAST14

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili258 – 553Sequence analysisAdd BLAST296
Coiled coili675 – 835Sequence analysisAdd BLAST161
Coiled coili1010 – 1146Sequence analysisAdd BLAST137
Coiled coili1299 – 1949Sequence analysisAdd BLAST651
Coiled coili2064 – 2082Sequence analysisAdd BLAST19
Coiled coili2536 – 3086Sequence analysisAdd BLAST551

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi214 – 795Glu-richAdd BLAST582

Domaini

Composed of a coiled-coil central region flanked by non-helical N- and C-terminals.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJHT. Eukaryota.
ENOG4110FJZ. LUCA.
GeneTreeiENSGT00730000110871.
HOGENOMiHOG000168229.
HOVERGENiHBG079443.
InParanoidiO95613.
KOiK16481.
OMAiLETEHKV.
OrthoDBiEOG091G001R.
PhylomeDBiO95613.
TreeFamiTF336114.

Family and domain databases

InterProiIPR019528. PACT_domain.
IPR024151. Pericentrin.
[Graphical view]
PANTHERiPTHR18937:SF204. PTHR18937:SF204. 13 hits.
PfamiPF10495. PACT_coil_coil. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95613-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVEQEQRRR KVEAGRTKLA HFRQRKTKGD SSHSEKKTAK RKGSAVDASV
60 70 80 90 100
QEESPVTKED SALCGGGDIC KSTSCDDTPD GAGGAFAAQP EDCDGEKRED
110 120 130 140 150
LEQLQQKQVN DHPPEQCGMF TVSDHPPEQH GMFTVGDHPP EQRGMFTVSD
160 170 180 190 200
HPPEQHGMFT VSDHPPEQRG MFTISDHQPE QRGMFTVSDH TPEQRGIFTI
210 220 230 240 250
SDHPAEQRGM FTKECEQECE LAITDLESGR EDEAGLHQSQ AVHGLELEAL
260 270 280 290 300
RLSLSNMHTA QLELTQANLQ KEKETALTEL REMLNSRRAQ ELALLQSRQQ
310 320 330 340 350
HELELLREQH AREKEEVVLR CGQEAAELKE KLQSEMEKNA QIVKTLKEDW
360 370 380 390 400
ESEKDLCLEN LRKELSAKHQ SEMEDLQNQF QKELAEQRAE LEKIFQDKNQ
410 420 430 440 450
AERALRNLES HHQAAIEKLR EDLQSEHGRC LEDLEFKFKE SEKEKQLELE
460 470 480 490 500
NLQASYEDLK AQSQEEIRRL WSQLDSARTS RQELSELHEQ LLARTSRVED
510 520 530 540 550
LEQLKQREKT QHESELEQLR IYFEKKLRDA EKTYQEDLTL LQQRLQGARE
560 570 580 590 600
DALLDSVEVG LSCVGLEEKP EKGRKDHVDE LEPERHKESL PRFQAELEES
610 620 630 640 650
HRHQLEALES PLCIQHEGHV SDRCCVETSA LGHEWRLEPS EGHSQELPWV
660 670 680 690 700
HLQGVQDGDL EADTERAARV LGLETEHKVQ LSLLQTELKE EIELLKIENR
710 720 730 740 750
NLYGKLQHET RLKDDLEKVK HNLIEDHQKE LNNAKQKTEL MKQEFQRKET
760 770 780 790 800
DWKVMKEELQ REAEEKLTLM LLELREKAES EKQTIINKFE LREAEMRQLQ
810 820 830 840 850
DQQAAQILDL ERSLTEQQGR LQQLEQDLTS DDALHCSQCG REPPTAQDGE
860 870 880 890 900
LAALHVKEDC ALQLMLARSR FLEERKEITE KFSAEQDAFL QEAQEQHARE
910 920 930 940 950
LQLLQERHQQ QLLSVTAELE ARHQAALGEL TASLESKQGA LLAARVAELQ
960 970 980 990 1000
TKHAADLGAL ETRHLSSLDS LESCYLSEFQ TIREEHRQAL ELLRADFEEQ
1010 1020 1030 1040 1050
LWKKDSLHQT ILTQELEKLK RKHEGELQSV RDHLRTEVST ELAGTVAHEL
1060 1070 1080 1090 1100
QGVHQGEFGS EKKTALHEKE ETLRLQSAQA QPFHQEEKES LSLQLQKKNH
1110 1120 1130 1140 1150
QVQQLKDQVL SLSHEIEECR SELEVLQQRR ERENREGANL LSMLKADVNL
1160 1170 1180 1190 1200
SHSERGALQD ALRRLLGLFG ETLRAAVTLR SRIGERVGLC LDDAGAGLAL
1210 1220 1230 1240 1250
STAPALEETW SDVALPELDR TLSECAEMSS VAEISSHMRE SFLMSPESVR
1260 1270 1280 1290 1300
ECEQPIRRVF QSLSLAVDGL MEMALDSSRQ LEEARQIHSR FEKEFSFKNE
1310 1320 1330 1340 1350
ETAQVVRKHQ ELLECLKEES AAKAELALEL HKTQGTLEGF KVETADLKEV
1360 1370 1380 1390 1400
LAGKEDSEHR LVLELESLRR QLQQAAQEQA ALREECTRLW SRGEATATDA
1410 1420 1430 1440 1450
EAREAALRKE VEDLTKEQSE TRKQAEKDRS ALLSQMKILE SELEEQLSQH
1460 1470 1480 1490 1500
RGCAKQAEAV TALEQQVASL DKHLRNQRQF MDEQAAEREH EREEFQQEIQ
1510 1520 1530 1540 1550
RLEGQLRQAA KPQPWGPRDS QQAPLDGEVE LLQQKLREKL DEFNELAIQK
1560 1570 1580 1590 1600
ESADRQVLMQ EEEIKRLEEM NINIRKKVAQ LQEEVEKQKN IVKGLEQDKE
1610 1620 1630 1640 1650
VLKKQQMSSL LLASTLQSTL DAGRCPEPPS GSPPEGPEIQ LEVTQRALLR
1660 1670 1680 1690 1700
RESEVLDLKE QLEKMKGDLE SKNEEILHLN LKLDMQNSQT AVSLRELEEE
1710 1720 1730 1740 1750
NTSLKVIYTR SSEIEELKAT IENLQENQKR LQKEKAEEIE QLHEVIEKLQ
1760 1770 1780 1790 1800
HELSLMGPVV HEVSDSQAGS LQSELLCSQA GGPRGQALQG ELEAALEAKE
1810 1820 1830 1840 1850
ALSRLLADQE RRHSQALEAL QQRLQGAEEA AELQLAELER NVALREAEVE
1860 1870 1880 1890 1900
DMASRIQEFE AALKAKEATI AERNLEIDAL NQRKAAHSAE LEAVLLALAR
1910 1920 1930 1940 1950
IRRALEQQPL AAGAAPPELQ WLRAQCARLS RQLQVLHQRF LRCQVELDRR
1960 1970 1980 1990 2000
QARRATAHTR VPGAHPQPRM DGGAKAQVTG DVEASHDAAL EPVVPDPQGD
2010 2020 2030 2040 2050
LQPVLVTLKD APLCKQEGVM SVLTVCQRQL QSELLLVKNE MRLSLEDGGK
2060 2070 2080 2090 2100
GKEKVLEDCQ LPKVDLVAQV KQLQEKLNRL LYSMTFQNVD AADTKSLWPM
2110 2120 2130 2140 2150
ASAHLLESSW SDDSCDGEEP DISPHIDTCD ANTATGGVTD VIKNQAIDAC
2160 2170 2180 2190 2200
DANTTPGGVT DVIKNWDSLI PDEMPDSPIQ EKSECQDMSL SSPTSVLGGS
2210 2220 2230 2240 2250
RHQSHTAEAG PRKSPVGMLD LSSWSSPEVL RKDWTLEPWP SLPVTPHSGA
2260 2270 2280 2290 2300
LSLCSADTSL GDRADTSLPQ TQGPGLLCSP GVSAAALALQ WAESPPADDH
2310 2320 2330 2340 2350
HVQRTAVEKD VEDFITTSFD SQETLSSPPP GLEGKADRSE KSDGSGFGAR
2360 2370 2380 2390 2400
LSPGSGGPEA QTAGPVTPAS ISGRFQPLPE AMKEKEVRPK HVKALLQMVR
2410 2420 2430 2440 2450
DESHQILALS EGLAPPSGEP HPPRKEDEIQ DISLHGGKTQ EVPTACPDWR
2460 2470 2480 2490 2500
GDLLQVVQEA FEKEQEMQGV ELQPRLSGSD LGGHSSLLER LEKIIREQGD
2510 2520 2530 2540 2550
LQEKSLEHLR LPDRSSLLSE IQALRAQLRM THLQNQEKLQ HLRTALTSAE
2560 2570 2580 2590 2600
ARGSQQEHQL RRQVELLAYK VEQEKCIAGD LQKTLSEEQE KANSVQKLLA
2610 2620 2630 2640 2650
AEQTVVRDLK SDLCESRQKS EQLSRSLCEV QQEVLQLRSM LSSKENELKA
2660 2670 2680 2690 2700
ALQELESEQG KGRALQSQLE EEQLRHLQRE SQSAKALEEL RASLETQRAQ
2710 2720 2730 2740 2750
SSRLCVALKH EQTAKDNLQK ELRIEHSRCE ALLAQERSQL SELQKDLAAE
2760 2770 2780 2790 2800
KSRTLELSEA LRHERLLTEQ LSQRTQEACV HQDTQAHHAL LQKLKEEKSR
2810 2820 2830 2840 2850
VVDLQAMLEK VQQQALHSQQ QLEAEAQKHC EALRREKEVS ATLKSTVEAL
2860 2870 2880 2890 2900
HTQKRELRCS LEREREKPAW LQAELEQSHP RLKEQEGRKA ARRSAEARQS
2910 2920 2930 2940 2950
PAAAEQWRKW QRDKEKLREL ELQRQRDLHK IKQLQQTVRD LESKDEVPGS
2960 2970 2980 2990 3000
RLHLGSARRA AGSDADHLRE QQRELEAMRQ RLLSAARLLT SFTSQAVDRT
3010 3020 3030 3040 3050
VNDWTSSNEK AVMSLLHTLE ELKSDLSRPT SSQKKMAAEL QFQFVDVLLK
3060 3070 3080 3090 3100
DNVSLTKALS TVTQEKLELS RAVSKLEKLL KHHLQKGCSP SRSERSAWKP
3110 3120 3130 3140 3150
DETAPQSSLR RPDPGRLPPA ASEEAHTSNV KMEKLYLHYL RAESFRKALI
3160 3170 3180 3190 3200
YQKKYLLLLI GGFQDSEQET LSMIAHLGVF PSKAERKITS RPFTRFRTAV
3210 3220 3230 3240 3250
RVVIAILRLR FLVKKWQEVD RKGALAQGKA PRPGPRARQP QSPPRTRESP
3260 3270 3280 3290 3300
PTRDVPSGHT RDPARGRRLA AAASPHSGGR ATPSPNSRLE RSLTASQDPE
3310 3320 3330
HSLTEYIHHL EVIQQRLGGV LPDSTSKKSC HPMIKQ
Length:3,336
Mass (Da):378,037
Last modified:November 30, 2010 - v4
Checksum:i4F182D2C201662A8
GO
Isoform 2 (identifier: O95613-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.
     2839-2917: Missing.

Note: No experimental confirmation available.
Show »
Length:3,139
Mass (Da):355,882
Checksum:iA0FD227ABCF410FD
GO

Sequence cautioni

The sequence AAD10838 differs from that shown. Reason: Frameshift at position 3320.Curated
The sequence BAA23698 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC04252 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti703Y → F in AAD10838 (PubMed:11171385).Curated1
Sequence conflicti789F → L in AAD10838 (PubMed:11171385).Curated1
Sequence conflicti819G → A in AAD10838 (PubMed:11171385).Curated1
Sequence conflicti890 – 900Missing in AAD10838 (PubMed:11171385).CuratedAdd BLAST11
Sequence conflicti967S → T in AAD10838 (PubMed:11171385).Curated1
Sequence conflicti1024E → K in AAD10838 (PubMed:11171385).Curated1
Sequence conflicti1036T → A in BAC04252 (PubMed:14702039).Curated1
Sequence conflicti1287I → L in AAD10838 (PubMed:11171385).Curated1
Sequence conflicti1317K → T in AAD10838 (PubMed:11171385).Curated1
Sequence conflicti1534Q → H in AAD10838 (PubMed:11171385).Curated1
Sequence conflicti3136Y → S in AAD10838 (PubMed:11171385).Curated1
Sequence conflicti3300E → G in AAD10838 (PubMed:11171385).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043878539T → I.Corresponds to variant rs2249060dbSNPEnsembl.1
Natural variantiVAR_043879704G → E.3 PublicationsCorresponds to variant rs2839223dbSNPEnsembl.1
Natural variantiVAR_043880879T → A.1 PublicationCorresponds to variant rs2839227dbSNPEnsembl.1
Natural variantiVAR_0438811038V → A.3 PublicationsCorresponds to variant rs6518289dbSNPEnsembl.1
Natural variantiVAR_0438821163R → C.Corresponds to variant rs7279204dbSNPEnsembl.1
Natural variantiVAR_0438831194A → T.Corresponds to variant rs35044802dbSNPEnsembl.1
Natural variantiVAR_0694201452G → R Found in a patient with mental retardation, no speech, facial and limbs dysmorphisms. 1 PublicationCorresponds to variant rs143796569dbSNPEnsembl.1
Natural variantiVAR_0438841639I → V.Corresponds to variant rs6518291dbSNPEnsembl.1
Natural variantiVAR_0438851841N → S.Corresponds to variant rs35940413dbSNPEnsembl.1
Natural variantiVAR_0438861953R → H.Corresponds to variant rs34268261dbSNPEnsembl.1
Natural variantiVAR_0438871960R → Q.Corresponds to variant rs34813667dbSNPEnsembl.1
Natural variantiVAR_0438882097L → P.Corresponds to variant rs2839245dbSNPEnsembl.1
Natural variantiVAR_0438892125H → P.Corresponds to variant rs35978208dbSNPEnsembl.1
Natural variantiVAR_0438902188M → R.1 PublicationCorresponds to variant rs1044998dbSNPEnsembl.1
Natural variantiVAR_0438912191S → P.Corresponds to variant rs34151633dbSNPEnsembl.1
Natural variantiVAR_0569612239W → R.Corresponds to variant rs35346764dbSNPEnsembl.1
Natural variantiVAR_0569622274P → L.Corresponds to variant rs2070425dbSNPEnsembl.1
Natural variantiVAR_0569632329P → R.Corresponds to variant rs35848602dbSNPEnsembl.1
Natural variantiVAR_0569642361Q → R.Corresponds to variant rs7277175dbSNPEnsembl.1
Natural variantiVAR_0694212424R → Q Found in a patient with mental retardation, no speech, facial and limbs dysmorphisms. 1 PublicationCorresponds to variant rs371893416dbSNPEnsembl.1
Natural variantiVAR_0569652549A → T.1 PublicationCorresponds to variant rs2839256dbSNPEnsembl.1
Natural variantiVAR_0569662625R → Q.Corresponds to variant rs8131693dbSNPEnsembl.1
Natural variantiVAR_0569672659Q → H.Corresponds to variant rs2070426dbSNPEnsembl.1
Natural variantiVAR_0569682753R → H.Corresponds to variant rs743346dbSNPEnsembl.1
Natural variantiVAR_0569692792Q → R.Corresponds to variant rs2073376dbSNPEnsembl.1
Natural variantiVAR_0569702903A → T.Corresponds to variant rs35147998dbSNPEnsembl.1
Natural variantiVAR_0569712975L → P.Corresponds to variant rs35881595dbSNPEnsembl.1
Natural variantiVAR_0569723091S → G.Corresponds to variant rs4818842dbSNPEnsembl.1
Natural variantiVAR_0569733245R → S.Corresponds to variant rs2073380dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0401041 – 118Missing in isoform 2. 1 PublicationAdd BLAST118
Alternative sequenceiVSP_0401052839 – 2917Missing in isoform 2. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52962 mRNA. Translation: AAD10838.1. Frameshift.
AF515282 mRNA. Translation: AAP46636.1.
AB007862 mRNA. Translation: BAA23698.3. Different initiation.
AP000471 Genomic DNA. No translation available.
AP001477 Genomic DNA. No translation available.
AP000335 Genomic DNA. No translation available.
AP000336 Genomic DNA. No translation available.
AP000337 Genomic DNA. No translation available.
AK093923 mRNA. Translation: BAC04252.1. Different initiation.
CCDSiCCDS33592.1. [O95613-1]
RefSeqiNP_001302458.1. NM_001315529.1. [O95613-2]
NP_006022.3. NM_006031.5. [O95613-1]
UniGeneiHs.474069.

Genome annotation databases

EnsembliENST00000359568; ENSP00000352572; ENSG00000160299. [O95613-1]
GeneIDi5116.
KEGGihsa:5116.
UCSCiuc002zji.4. human. [O95613-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52962 mRNA. Translation: AAD10838.1. Frameshift.
AF515282 mRNA. Translation: AAP46636.1.
AB007862 mRNA. Translation: BAA23698.3. Different initiation.
AP000471 Genomic DNA. No translation available.
AP001477 Genomic DNA. No translation available.
AP000335 Genomic DNA. No translation available.
AP000336 Genomic DNA. No translation available.
AP000337 Genomic DNA. No translation available.
AK093923 mRNA. Translation: BAC04252.1. Different initiation.
CCDSiCCDS33592.1. [O95613-1]
RefSeqiNP_001302458.1. NM_001315529.1. [O95613-2]
NP_006022.3. NM_006031.5. [O95613-1]
UniGeneiHs.474069.

3D structure databases

ProteinModelPortaliO95613.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111146. 68 interactors.
DIPiDIP-33829N.
IntActiO95613. 40 interactors.
MINTiMINT-4527763.
STRINGi9606.ENSP00000352572.

PTM databases

iPTMnetiO95613.
PhosphoSitePlusiO95613.

Polymorphism and mutation databases

BioMutaiPCNT.

Proteomic databases

EPDiO95613.
MaxQBiO95613.
PaxDbiO95613.
PeptideAtlasiO95613.
PRIDEiO95613.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359568; ENSP00000352572; ENSG00000160299. [O95613-1]
GeneIDi5116.
KEGGihsa:5116.
UCSCiuc002zji.4. human. [O95613-1]

Organism-specific databases

CTDi5116.
DisGeNETi5116.
GeneCardsiPCNT.
H-InvDBHIX0203117.
HGNCiHGNC:16068. PCNT.
HPAiHPA016820.
HPA019887.
HPA032101.
MalaCardsiPCNT.
MIMi210720. phenotype.
605925. gene.
neXtProtiNX_O95613.
OpenTargetsiENSG00000160299.
Orphaneti2637. Microcephalic osteodysplastic primordial dwarfism type II.
808. Seckel syndrome.
PharmGKBiPA33079.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJHT. Eukaryota.
ENOG4110FJZ. LUCA.
GeneTreeiENSGT00730000110871.
HOGENOMiHOG000168229.
HOVERGENiHBG079443.
InParanoidiO95613.
KOiK16481.
OMAiLETEHKV.
OrthoDBiEOG091G001R.
PhylomeDBiO95613.
TreeFamiTF336114.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160299-MONOMER.
ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.
SIGNORiO95613.

Miscellaneous databases

ChiTaRSiPCNT. human.
GeneWikiiPCNT.
GenomeRNAii5116.
PROiO95613.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160299.
CleanExiHS_PCNT.
ExpressionAtlasiO95613. baseline and differential.
GenevisibleiO95613. HS.

Family and domain databases

InterProiIPR019528. PACT_domain.
IPR024151. Pericentrin.
[Graphical view]
PANTHERiPTHR18937:SF204. PTHR18937:SF204. 13 hits.
PfamiPF10495. PACT_coil_coil. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCNT_HUMAN
AccessioniPrimary (citable) accession number: O95613
Secondary accession number(s): O43152, Q7Z7C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 163 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.