KLF8

Functionⁱ

Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G₁ phase as a downstream target of focal adhesion kinase (FAK).3 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	274 – 298	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	304 – 328	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	334 – 356	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 10756197
RNA polymerase II transcription factor activity, sequence-specific DNA binding
Source: NTNU_SB
Non-traceable author statementⁱ
- 19274049
transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 10756197

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from mutant phenotypeⁱ
- 10756197
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SIGNORⁱ	O95600.

SIGNORⁱ

O95600.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Krueppel-like factor 8 Alternative name(s): Basic krueppel-like factor 3 Zinc finger protein 741
Gene namesⁱ	Name:KLF8 Synonyms:BKLF3, ZNF741
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000102349.15.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6351. KLF8.
MIMⁱ	300286. gene.
neXtProtⁱ	NX_O95600.

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	67	K → R: Abolishes sumoylation. No change in nuclear location. Increases transcriptional activity and cell cycle progression. Abolishes sumoylation; when associated with R-217. 1 Publication		1
Mutagenesisⁱ	217	K → R: No change in sumoylation. Abolishes sumoylation; when associated with R-67. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11279.
Open Targets More...OpenTargetsⁱ	ENSG00000102349.
PharmGKBⁱ	PA30141.

Polymorphism and mutation databases

BioMutaⁱ	KLF8.

BioMutaⁱ

KLF8.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047176	1 – 359	Krueppel-like factor 8Add BLAST		359

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	67	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Post-translational modificationⁱ

Sumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G₁ phase. Has no effect on subcellular location.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbⁱ	O95600.
PeptideAtlas More...PeptideAtlasⁱ	O95600.
PRIDEⁱ	O95600.

PTM databases

iPTMnetⁱ	O95600.
PhosphoSitePlusⁱ	O95600.

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000102349.
CleanExⁱ	HS_KLF8.
ExpressionAtlasⁱ	O95600. baseline and differential.
Genevisibleⁱ	O95600. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA071740.

HPAⁱ

HPA071740.

Interactionⁱ

Subunit structureⁱ

Interacts with corepressor CtBP2. Interacts with PIAS1, PIAS2, AND PIAS4; the interaction with each ligase sumoylates KLF8.2 Publications

Protein-protein interaction databases

BioGridⁱ	116435. 13 interactors.
ELMⁱ	O95600.
IntActⁱ	O95600. 6 interactors.
Molecular INTeraction database More...MINTⁱ	O95600.
STRINGⁱ	9606.ENSP00000417303.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O95600.
SMRⁱ	O95600.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	274 – 298	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	304 – 328	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	334 – 356	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721. Eukaryota. COG5048. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118998.
HOVERGENⁱ	HBG003941.
InParanoidⁱ	O95600.
KEGG Orthology (KO) More...KOⁱ	K09205.
OMAⁱ	PAAMTQM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1BN0.
PhylomeDBⁱ	O95600.
TreeFamⁱ	TF350556.

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236. Znf_C2H2_sf. IPR013087. Znf_C2H2_type.
SMARTⁱ	View protein in SMART SM00355. ZnF_C2H2. 3 hits.
SUPFAMⁱ	SSF57667. SSF57667. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 3 hits.

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: O95600-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVDMDKLINN LEVQLNSEGG SMQVFKQVTA SVRNRDPPEI EYRSNMTSPT 
        60         70         80         90        100
LLDANPMENP ALFNDIKIEP PEELLASDFS LPQVEPVDLS FHKPKAPLQP 
       110        120        130        140        150
ASMLQAPIRP PKPQSSPQTL VVSTSTSDMS TSANIPTVLT PGSVLTSSQS 
       160        170        180        190        200
TGSQQILHVI HTIPSVSLPN KMGGLKTIPV VVQSLPMVYT TLPADGGPAA 
       210        220        230        240        250
ITVPLIGGDG KNAGSVKVDP TSMSPLEIPS DSEESTIESG SSALQSLQGL 
       260        270        280        290        300
QQEPAAMAQM QGEESLDLKR RRIHQCDFAG CSKVYTKSSH LKAHRRIHTG 
       310        320        330        340        350
EKPYKCTWDG CSWKFARSDE LTRHFRKHTG IKPFRCTDCN RSFSRSDHLS 

LHRRRHDTM

Length:359

Mass (Da):39,314

Last modified:November 2, 2001 - v2

Checksum:ⁱF8FDCC1FD477C04F

GO

Isoform 2 (identifier: O95600-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
254-359: PAAMAQMQGE...SLHRRRHDTM → REAL

« Hide

        10         20         30         40         50
MVDMDKLINN LEVQLNSEGG SMQVFKQVTA SVRNRDPPEI EYRSNMTSPT 
        60         70         80         90        100
LLDANPMENP ALFNDIKIEP PEELLASDFS LPQVEPVDLS FHKPKAPLQP 
       110        120        130        140        150
ASMLQAPIRP PKPQSSPQTL VVSTSTSDMS TSANIPTVLT PGSVLTSSQS 
       160        170        180        190        200
TGSQQILHVI HTIPSVSLPN KMGGLKTIPV VVQSLPMVYT TLPADGGPAA 
       210        220        230        240        250
ITVPLIGGDG KNAGSVKVDP TSMSPLEIPS DSEESTIESG SSALQSLQGL 

QQEREAL

Show »

Length:257

Mass (Da):27,242

Checksum:ⁱ86CF13DBD7494270

GO

Isoform 3 (identifier: O95600-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-27: MVDMDKLINNLEVQLNSEGGSMQVFKQ → MSLPEDGMSSGHFRSPQLVTWS
254-359: PAAMAQMQGE...SLHRRRHDTM → REAL

« Hide

        10         20         30         40         50
MSLPEDGMSS GHFRSPQLVT WSVTASVRNR DPPEIEYRSN MTSPTLLDAN 
        60         70         80         90        100
PMENPALFND IKIEPPEELL ASDFSLPQVE PVDLSFHKPK APLQPASMLQ 
       110        120        130        140        150
APIRPPKPQS SPQTLVVSTS TSDMSTSANI PTVLTPGSVL TSSQSTGSQQ 
       160        170        180        190        200
ILHVIHTIPS VSLPNKMGGL KTIPVVVQSL PMVYTTLPAD GGPAAITVPL 
       210        220        230        240        250
IGGDGKNAGS VKVDPTSMSP LEIPSDSEES TIESGSSALQ SLQGLQQERE 

AL

Show »

Length:252

Mass (Da):26,623

Checksum:ⁱ0B68B09E33AC87A8

GO

Isoform 4 (identifier: O95600-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
216-299: Missing.

« Hide

        10         20         30         40         50
MVDMDKLINN LEVQLNSEGG SMQVFKQVTA SVRNRDPPEI EYRSNMTSPT 
        60         70         80         90        100
LLDANPMENP ALFNDIKIEP PEELLASDFS LPQVEPVDLS FHKPKAPLQP 
       110        120        130        140        150
ASMLQAPIRP PKPQSSPQTL VVSTSTSDMS TSANIPTVLT PGSVLTSSQS 
       160        170        180        190        200
TGSQQILHVI HTIPSVSLPN KMGGLKTIPV VVQSLPMVYT TLPADGGPAA 
       210        220        230        240        250
ITVPLIGGDG KNAGSGEKPY KCTWDGCSWK FARSDELTRH FRKHTGIKPF 
       260        270 
RCTDCNRSFS RSDHLSLHRR RHDTM

Show »

Length:275

Mass (Da):30,050

Checksum:ⁱ7CB5F2431F0E06D0

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	167	S → I in BAG58895 (PubMed:14702039).Curated		1
Sequence conflictⁱ	263	E → G in AAC99849 (Ref. 1) Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_047480	1 – 27	MVDMD…QVFKQ → MSLPEDGMSSGHFRSPQLVT WS in isoform 3. 1 PublicationAdd BLAST	27
Alternative sequenceⁱVSP_047481	216 – 299	Missing in isoform 4. 1 PublicationAdd BLAST	84
Alternative sequenceⁱVSP_045460	254 – 359	PAAMA…RHDTM → REAL in isoform 2 and isoform 3. 2 PublicationsAdd BLAST	106

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U28282 mRNA. Translation: AAC99849.1. HF546207 mRNA. Translation: CCO02793.1. HF546208 mRNA. Translation: CCO02794.1. HF546209 mRNA. Translation: CCO02795.1. AK296156 mRNA. Translation: BAG58895.1. AB209004 mRNA. Translation: BAD92241.1. Sequence problems. BX641066 mRNA. Translation: CAE46033.1. Sequence problems. BX322609, AL050309 Genomic DNA. Translation: CAI41397.1. AL050309, BX322609 Genomic DNA. Translation: CAI42343.1. BC105130 mRNA. Translation: AAI05131.1. BC112109 mRNA. Translation: AAI12110.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14373.1. [O95600-1] CCDS55428.1. [O95600-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001152768.1. NM_001159296.2. [O95600-3] NP_001311028.1. NM_001324099.1. [O95600-4] NP_001311029.1. NM_001324100.1. [O95600-5] NP_001311031.1. NM_001324102.1. [O95600-1] NP_009181.2. NM_007250.5. [O95600-1] XP_005262034.1. XM_005261977.2. [O95600-1] XP_005262036.1. XM_005261979.3. [O95600-1] XP_006724638.1. XM_006724575.2. [O95600-3]
UniGeneⁱ	Hs.646614.

Genome annotation databases

Ensemblⁱ	ENST00000374928; ENSP00000364063; ENSG00000102349. [O95600-3] ENST00000468660; ENSP00000417303; ENSG00000102349. [O95600-1] ENST00000640927; ENSP00000492126; ENSG00000102349. [O95600-4]
GeneIDⁱ	11279.
KEGGⁱ	hsa:11279.
UCSC genome browser More...UCSCⁱ	uc004dur.4. human. [O95600-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O95600	A0A024R9X4 A0A2I3TQK3 H9F9Y5 UPI0007DBDE72 UPI00002120B4	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Macaca mulatta (Rhesus macaque)	359	UniRef100_O95600	Cluster: Krueppel-like factor 8	6
O95600-3	A0A2I3RNS0 UPI0007DBEBD1	Pan troglodytes (Chimpanzee)	257	UniRef100_A0A2I3RNS0	Cluster: KLF8 isoform 1	3
O95600-4	H2R432	Pan troglodytes (Chimpanzee)	252	UniRef100_H2R432	Cluster: KLF8 isoform 5	2
O95600-5	D2I7P7	Ailuropoda melanoleuca (Giant panda)	275	UniRef100_O95600-5	Cluster: Isoform 4 of Krueppel-like factor 8	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O95600	A0A024R9X4 A0A2I3TQK3 H9F9Y5 UPI0007DBDE72 UPI00002120B4	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Macaca mulatta (Rhesus macaque)	359	UniRef90_O95600	Cluster: Krueppel-like factor 8	6
O95600-3	A0A2I3RNS0 UPI0007DBEBD1	Pan troglodytes (Chimpanzee)	257	UniRef90_A0A2I3RNS0	Cluster: KLF8 isoform 1	3
O95600-4	H2R432 A0A2I2ZN46 A0A2K6SVG4 A0A2I3HJQ9 A0A2I3LLQ8	Pan troglodytes (Chimpanzee) Gorilla gorilla gorilla (Western lowland gorilla) Saimiri boliviensis boliviensis (Bolivian squirrel monkey) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Papio anubis (Olive baboon)	252	UniRef90_H2R432	Cluster: KLF8 isoform 5	6
O95600-5	D2I7P7 Q05BZ3 A0A2J8J309 A0A2I3TRS1 A0A2J8RB06 A0A2I3G1M2 A0A2I2YRH9	Ailuropoda melanoleuca (Giant panda) Homo sapiens (Human) Pan troglodytes (Chimpanzee) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Gorilla gorilla gorilla (Western lowland gorilla)	275	UniRef90_O95600-5	Cluster: Isoform 4 of Krueppel-like factor 8	8

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O95600	A0A024R9X4 A0A2I3TQK3 H9F9Y5 UPI0007DBDE72 UPI00002120B4 A0A2K5LP11 UPI0005F52F49 UPI0007B3C1E5 UPI0004F0AE1E I3MIE3 +6	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Macaca mulatta (Rhesus macaque) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Pan paniscus (Pygmy chimpanzee) (Bonobo) Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus) Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat) Rhinolophus sinicus (Chinese rufous horseshoe bat) Myotis brandtii (Brandt's bat) Peromyscus maniculatus bairdii (Prairie deer mouse)	359	UniRef50_O95600	Cluster: Krueppel-like factor 8	17
O95600-3	H0VGA1 UPI00022B2FCA UPI0007871EB4 UPI0002742B7C UPI0003AE288E F1PAS3 M3WHB1 UPI00042C0388 UPI00072E286C UPI000813786E +53	Cavia porcellus (Guinea pig) Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat) Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) Canis lupus familiaris (Dog) (Canis familiaris) Felis catus (Cat) (Felis silvestris catus) Panthera tigris altaica (Siberian tiger) Acinonyx jubatus (Cheetah) Manis javanica (Malayan pangolin) (Sunda pangolin) Myotis lucifugus (Little brown bat) Ceratotherium simum simum (southern white rhinoceros) And more	356	UniRef50_H0VGA1	Cluster: Kruppel like factor 8	64
O95600-4	H2R432 A0A2K6SVG4 A0A2I3HJQ9 A0A2I2ZN46 A0A2I3LLQ8 UPI000809DD7D UPI00083FE49F F6WJD6 A0A2K6SVG7 A0A2K5QGH7 +7	Pan troglodytes (Chimpanzee) Saimiri boliviensis boliviensis (Bolivian squirrel monkey) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Gorilla gorilla gorilla (Western lowland gorilla) Papio anubis (Olive baboon) Cebus capucinus imitator Callithrix jacchus (White-tufted-ear marmoset) Aotus nancymaae (Ma's night monkey) Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli) Cyanistes caeruleus (Eurasian blue tit) (Parus caeruleus)	252	UniRef50_H2R432	Cluster: KLF8 isoform 5	18
O95600-5	D2I7P7 Q05BZ3 A0A2J8J309 A0A2I3TRS1 A0A2J8RB06 A0A2I2YRH9 A0A2I3G1M2 UPI000C7EB1BD H0WG86 L8YAT9 +9	Ailuropoda melanoleuca (Giant panda) Homo sapiens (Human) Pan troglodytes (Chimpanzee) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Gorilla gorilla gorilla (Western lowland gorilla) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) Tupaia chinensis (Chinese tree shrew) Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus) Pteropus alecto (Black flying fox) And more	275	UniRef50_O95600-5	Cluster: Isoform 4 of Krueppel-like factor 8	20

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U28282 mRNA. Translation: AAC99849.1. HF546207 mRNA. Translation: CCO02793.1. HF546208 mRNA. Translation: CCO02794.1. HF546209 mRNA. Translation: CCO02795.1. AK296156 mRNA. Translation: BAG58895.1. AB209004 mRNA. Translation: BAD92241.1. Sequence problems. BX641066 mRNA. Translation: CAE46033.1. Sequence problems. BX322609, AL050309 Genomic DNA. Translation: CAI41397.1. AL050309, BX322609 Genomic DNA. Translation: CAI42343.1. BC105130 mRNA. Translation: AAI05131.1. BC112109 mRNA. Translation: AAI12110.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14373.1. [O95600-1] CCDS55428.1. [O95600-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001152768.1. NM_001159296.2. [O95600-3] NP_001311028.1. NM_001324099.1. [O95600-4] NP_001311029.1. NM_001324100.1. [O95600-5] NP_001311031.1. NM_001324102.1. [O95600-1] NP_009181.2. NM_007250.5. [O95600-1] XP_005262034.1. XM_005261977.2. [O95600-1] XP_005262036.1. XM_005261979.3. [O95600-1] XP_006724638.1. XM_006724575.2. [O95600-3]
UniGeneⁱ	Hs.646614.

3D structure databases

ProteinModelPortalⁱ	O95600.
SMRⁱ	O95600.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116435. 13 interactors.
ELMⁱ	O95600.
IntActⁱ	O95600. 6 interactors.
Molecular INTeraction database More...MINTⁱ	O95600.
STRINGⁱ	9606.ENSP00000417303.

PTM databases

iPTMnetⁱ	O95600.
PhosphoSitePlusⁱ	O95600.

Polymorphism and mutation databases

BioMutaⁱ	KLF8.

BioMutaⁱ

KLF8.

Proteomic databases

PaxDbⁱ	O95600.
PeptideAtlas More...PeptideAtlasⁱ	O95600.
PRIDEⁱ	O95600.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11279.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000374928; ENSP00000364063; ENSG00000102349. [O95600-3] ENST00000468660; ENSP00000417303; ENSG00000102349. [O95600-1] ENST00000640927; ENSP00000492126; ENSG00000102349. [O95600-4]
GeneIDⁱ	11279.
KEGGⁱ	hsa:11279.
UCSC genome browser More...UCSCⁱ	uc004dur.4. human. [O95600-1]

Organism-specific databases

CTDⁱ	11279.
DisGeNET More...DisGeNETⁱ	11279.
EuPathDBⁱ	HostDB:ENSG00000102349.15.
GeneCardsⁱ	KLF8.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6351. KLF8.
Human Protein Atlas More...HPAⁱ	HPA071740.
MIMⁱ	300286. gene.
neXtProtⁱ	NX_O95600.
Open Targets More...OpenTargetsⁱ	ENSG00000102349.
PharmGKBⁱ	PA30141.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721. Eukaryota. COG5048. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118998.
HOVERGENⁱ	HBG003941.
InParanoidⁱ	O95600.
KEGG Orthology (KO) More...KOⁱ	K09205.
OMAⁱ	PAAMTQM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1BN0.
PhylomeDBⁱ	O95600.
TreeFamⁱ	TF350556.

Enzyme and pathway databases

SIGNORⁱ	O95600.

SIGNORⁱ

O95600.

Miscellaneous databases

ChiTaRSⁱ	KLF8. human.
GeneWikiⁱ	KLF8.
GenomeRNAiⁱ	11279.
Protein Ontology More...PROⁱ	PR:O95600.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000102349.
CleanExⁱ	HS_KLF8.
ExpressionAtlasⁱ	O95600. baseline and differential.
Genevisibleⁱ	O95600. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236. Znf_C2H2_sf. IPR013087. Znf_C2H2_type.
SMARTⁱ	View protein in SMART SM00355. ZnF_C2H2. 3 hits.
SUPFAMⁱ	SSF57667. SSF57667. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 3 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KLF8_HUMAN
Accessionⁱ	O95600Primary (citable) accession number: O95600 Secondary accession number(s): B4DJN3 Q9UGC4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
	Last sequence update:	November 2, 2001
	Last modified:	March 28, 2018
	This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O95600 (KLF8_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Krueppel-like factor 8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ