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Protein

Krueppel-like factor 8

Gene

KLF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G1 phase as a downstream target of focal adhesion kinase (FAK).3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri274 – 29825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 8
Alternative name(s):
Basic krueppel-like factor 3
Zinc finger protein 741
Gene namesi
Name:KLF8
Synonyms:BKLF3, ZNF741
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6351. KLF8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi67 – 671K → R: Abolishes sumoylation. No change in nuclear location. Increases transcriptional activity and cell cycle progression. Abolishes sumoylation; when associated with R-217. 1 Publication
Mutagenesisi217 – 2171K → R: No change in sumoylation. Abolishes sumoylation; when associated with R-67. 1 Publication

Organism-specific databases

PharmGKBiPA30141.

Polymorphism and mutation databases

BioMutaiKLF8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Krueppel-like factor 8PRO_0000047176Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki67 – 67Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Post-translational modificationi

Sumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G1 phase. Has no effect on subcellular location.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiO95600.
PRIDEiO95600.

PTM databases

PhosphoSiteiO95600.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiO95600.
CleanExiHS_KLF8.
ExpressionAtlasiO95600. baseline and differential.
GenevisibleiO95600. HS.

Interactioni

Subunit structurei

Interacts with corepressor CtBP2. Interacts with PIAS1, PIAS2, AND PIAS4; the interaction with each ligase sumoylates KLF8.2 Publications

Protein-protein interaction databases

BioGridi116435. 9 interactions.
IntActiO95600. 1 interaction.
MINTiMINT-7969747.
STRINGi9606.ENSP00000417303.

Structurei

3D structure databases

ProteinModelPortaliO95600.
SMRiO95600. Positions 274-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri274 – 29825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118998.
HOVERGENiHBG003941.
InParanoidiO95600.
KOiK09205.
OMAiPVQIRDP.
OrthoDBiEOG7Z69CW.
PhylomeDBiO95600.
TreeFamiTF350556.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95600-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVDMDKLINN LEVQLNSEGG SMQVFKQVTA SVRNRDPPEI EYRSNMTSPT
60 70 80 90 100
LLDANPMENP ALFNDIKIEP PEELLASDFS LPQVEPVDLS FHKPKAPLQP
110 120 130 140 150
ASMLQAPIRP PKPQSSPQTL VVSTSTSDMS TSANIPTVLT PGSVLTSSQS
160 170 180 190 200
TGSQQILHVI HTIPSVSLPN KMGGLKTIPV VVQSLPMVYT TLPADGGPAA
210 220 230 240 250
ITVPLIGGDG KNAGSVKVDP TSMSPLEIPS DSEESTIESG SSALQSLQGL
260 270 280 290 300
QQEPAAMAQM QGEESLDLKR RRIHQCDFAG CSKVYTKSSH LKAHRRIHTG
310 320 330 340 350
EKPYKCTWDG CSWKFARSDE LTRHFRKHTG IKPFRCTDCN RSFSRSDHLS

LHRRRHDTM
Length:359
Mass (Da):39,314
Last modified:November 2, 2001 - v2
Checksum:iF8FDCC1FD477C04F
GO
Isoform 2 (identifier: O95600-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     254-359: PAAMAQMQGE...SLHRRRHDTM → REAL

Show »
Length:257
Mass (Da):27,242
Checksum:i86CF13DBD7494270
GO
Isoform 3 (identifier: O95600-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MVDMDKLINNLEVQLNSEGGSMQVFKQ → MSLPEDGMSSGHFRSPQLVTWS
     254-359: PAAMAQMQGE...SLHRRRHDTM → REAL

Show »
Length:252
Mass (Da):26,623
Checksum:i0B68B09E33AC87A8
GO
Isoform 4 (identifier: O95600-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-299: Missing.

Show »
Length:275
Mass (Da):30,050
Checksum:i7CB5F2431F0E06D0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti167 – 1671S → I in BAG58895 (PubMed:14702039).Curated
Sequence conflicti263 – 2631E → G in AAC99849 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2727MVDMD…QVFKQ → MSLPEDGMSSGHFRSPQLVT WS in isoform 3. 1 PublicationVSP_047480Add
BLAST
Alternative sequencei216 – 29984Missing in isoform 4. 1 PublicationVSP_047481Add
BLAST
Alternative sequencei254 – 359106PAAMA…RHDTM → REAL in isoform 2 and isoform 3. 2 PublicationsVSP_045460Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28282 mRNA. Translation: AAC99849.1.
HF546207 mRNA. Translation: CCO02793.1.
HF546208 mRNA. Translation: CCO02794.1.
HF546209 mRNA. Translation: CCO02795.1.
AK296156 mRNA. Translation: BAG58895.1.
AB209004 mRNA. Translation: BAD92241.1. Sequence problems.
BX641066 mRNA. Translation: CAE46033.1. Sequence problems.
BX322609, AL050309 Genomic DNA. Translation: CAI41397.1.
AL050309, BX322609 Genomic DNA. Translation: CAI42343.1.
BC105130 mRNA. Translation: AAI05131.1.
BC112109 mRNA. Translation: AAI12110.1.
CCDSiCCDS14373.1. [O95600-1]
CCDS55428.1. [O95600-3]
RefSeqiNP_001152768.1. NM_001159296.1. [O95600-3]
NP_009181.2. NM_007250.4. [O95600-1]
XP_005262034.1. XM_005261977.1. [O95600-1]
XP_005262035.1. XM_005261978.2. [O95600-1]
XP_005262036.1. XM_005261979.2. [O95600-1]
XP_006724638.1. XM_006724575.2. [O95600-3]
UniGeneiHs.646614.

Genome annotation databases

EnsembliENST00000374928; ENSP00000364063; ENSG00000102349. [O95600-3]
ENST00000468660; ENSP00000417303; ENSG00000102349. [O95600-1]
ENST00000624085; ENSP00000485372; ENSG00000102349. [O95600-4]
GeneIDi11279.
KEGGihsa:11279.
UCSCiuc004dur.3. human. [O95600-1]
uc011mop.2. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28282 mRNA. Translation: AAC99849.1.
HF546207 mRNA. Translation: CCO02793.1.
HF546208 mRNA. Translation: CCO02794.1.
HF546209 mRNA. Translation: CCO02795.1.
AK296156 mRNA. Translation: BAG58895.1.
AB209004 mRNA. Translation: BAD92241.1. Sequence problems.
BX641066 mRNA. Translation: CAE46033.1. Sequence problems.
BX322609, AL050309 Genomic DNA. Translation: CAI41397.1.
AL050309, BX322609 Genomic DNA. Translation: CAI42343.1.
BC105130 mRNA. Translation: AAI05131.1.
BC112109 mRNA. Translation: AAI12110.1.
CCDSiCCDS14373.1. [O95600-1]
CCDS55428.1. [O95600-3]
RefSeqiNP_001152768.1. NM_001159296.1. [O95600-3]
NP_009181.2. NM_007250.4. [O95600-1]
XP_005262034.1. XM_005261977.1. [O95600-1]
XP_005262035.1. XM_005261978.2. [O95600-1]
XP_005262036.1. XM_005261979.2. [O95600-1]
XP_006724638.1. XM_006724575.2. [O95600-3]
UniGeneiHs.646614.

3D structure databases

ProteinModelPortaliO95600.
SMRiO95600. Positions 274-356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116435. 9 interactions.
IntActiO95600. 1 interaction.
MINTiMINT-7969747.
STRINGi9606.ENSP00000417303.

PTM databases

PhosphoSiteiO95600.

Polymorphism and mutation databases

BioMutaiKLF8.

Proteomic databases

PaxDbiO95600.
PRIDEiO95600.

Protocols and materials databases

DNASUi11279.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374928; ENSP00000364063; ENSG00000102349. [O95600-3]
ENST00000468660; ENSP00000417303; ENSG00000102349. [O95600-1]
ENST00000624085; ENSP00000485372; ENSG00000102349. [O95600-4]
GeneIDi11279.
KEGGihsa:11279.
UCSCiuc004dur.3. human. [O95600-1]
uc011mop.2. human.

Organism-specific databases

CTDi11279.
GeneCardsiGC0XP056275.
HGNCiHGNC:6351. KLF8.
MIMi300286. gene.
neXtProtiNX_O95600.
PharmGKBiPA30141.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118998.
HOVERGENiHBG003941.
InParanoidiO95600.
KOiK09205.
OMAiPVQIRDP.
OrthoDBiEOG7Z69CW.
PhylomeDBiO95600.
TreeFamiTF350556.

Miscellaneous databases

GeneWikiiKLF8.
GenomeRNAii11279.
NextBioi42937.
PROiO95600.
SOURCEiSearch...

Gene expression databases

BgeeiO95600.
CleanExiHS_KLF8.
ExpressionAtlasiO95600. baseline and differential.
GenevisibleiO95600. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Gorski J.L., MacDonald M., Vananthwerp M., Burright E.N., Bialecki M.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors."
    Camacho-Vanegas O., Till J., Miranda-Lorenzo I., Ozturk B., Camacho S.C., Martignetti J.A.
    FASEB J. 27:432-436(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), ALTERNATIVE SPLICING.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thalamus.
  4. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  6. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  8. "Human Kruppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription."
    van Vliet J., Turner J., Crossley M.
    Nucleic Acids Res. 28:1955-1962(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
  9. "Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression."
    Zhao J., Bian Z.C., Yee K., Chen B.P., Chien S., Guan J.L.
    Mol. Cell 11:1503-1515(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation."
    Wei H., Wang X., Gan B., Urvalek A.M., Melkoumian Z.K., Guan J.-L., Zhao J.
    J. Biol. Chem. 281:16664-16671(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION AT LYS-67, INTERACTION WITH PIAS1; PIAS2 AND PIAS4, FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-67 AND LYS-217.

Entry informationi

Entry nameiKLF8_HUMAN
AccessioniPrimary (citable) accession number: O95600
Secondary accession number(s): B4DJN3
, E7EQQ8, L0R3U8, L0R4U2, Q2M246, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 2, 2001
Last modified: June 24, 2015
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.