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Protein

Histidine protein methyltransferase 1 homolog

Gene

METTL18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable histidine methyltransferase.By similarity

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB
  • methyltransferase activity Source: UniProtKB-KW

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine protein methyltransferase 1 homolog (EC:2.1.1.-)
Alternative name(s):
Arsenic-transactivated protein 2
Short name:
AsTP2
Methyltransferase-like protein 18
Gene namesi
Name:METTL18
Synonyms:ASTP2, C1orf156
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000171806.11
HGNCiHGNC:28793 METTL18
MIMi615255 gene
neXtProtiNX_O95568

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi92342
OpenTargetsiENSG00000171806
PharmGKBiPA142672407

Polymorphism and mutation databases

BioMutaiMETTL18

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002471991 – 372Histidine protein methyltransferase 1 homologAdd BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95568
MaxQBiO95568
PaxDbiO95568
PeptideAtlasiO95568
PRIDEiO95568

PTM databases

CarbonylDBiO95568
iPTMnetiO95568
PhosphoSitePlusiO95568

Expressioni

Gene expression databases

BgeeiENSG00000171806
CleanExiHS_C1orf156
ExpressionAtlasiO95568 baseline and differential
GenevisibleiO95568 HS

Organism-specific databases

HPAiHPA035314

Interactioni

Subunit structurei

Interacts with GRWD1, RPL3 and members of the heat shock protein 90 and 70 families; these proteins may possibly be methylation substrates for the enzyme.1 Publication

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124936, 46 interactors
IntActiO95568, 4 interactors
MINTiO95568
STRINGi9606.ENSP00000307077

Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi86 – 88Combined sources3
Beta strandi92 – 94Combined sources3
Beta strandi101 – 103Combined sources3
Helixi109 – 113Combined sources5
Beta strandi116 – 120Combined sources5
Beta strandi124 – 126Combined sources3
Beta strandi130 – 138Combined sources9
Beta strandi162 – 164Combined sources3
Helixi170 – 181Combined sources12
Beta strandi190 – 194Combined sources5
Helixi200 – 207Combined sources8
Beta strandi211 – 218Combined sources8
Helixi220 – 225Combined sources6
Helixi227 – 233Combined sources7
Helixi257 – 262Combined sources6
Beta strandi263 – 268Combined sources6
Helixi270 – 278Combined sources9
Beta strandi280 – 283Combined sources4
Beta strandi287 – 294Combined sources8
Helixi299 – 301Combined sources3
Helixi302 – 312Combined sources11
Beta strandi313 – 326Combined sources14
Turni328 – 330Combined sources3
Helixi334 – 344Combined sources11
Beta strandi346 – 355Combined sources10
Beta strandi357 – 359Combined sources3
Beta strandi361 – 368Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RFQX-ray2.40A63-372[»]
ProteinModelPortaliO95568
SMRiO95568
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2920 Eukaryota
ENOG4111NE8 LUCA
GeneTreeiENSGT00390000000464
HOVERGENiHBG053309
InParanoidiO95568
OMAiEWSEFCK
OrthoDBiEOG091G0J2W
PhylomeDBiO95568
TreeFamiTF320884

Family and domain databases

InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
SUPFAMiSSF53335 SSF53335, 1 hit

Sequencei

Sequence statusi: Complete.

O95568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFQFNFTIE DHLENELTPI RDGALTLDSS KELSVSESQK GEERDRKCSA
60 70 80 90 100
EQFDLPQDHL WEHKSMENAA PSQDTDSPLS AASSSRNLEP HGKQPSLRAA
110 120 130 140 150
KEHAMPKDLK KMLENKVIET LPGFQHVKLS VVKTILLKEN FPGENIVSKS
160 170 180 190 200
FSSHSDLITG VYEGGLKIWE CTFDLLAYFT KAKVKFAGKK VLDLGCGSGL
210 220 230 240 250
LGITAFKGGS KEIHFQDYNS MVIDEVTLPN VVANSTLEDE ENDVNEPDVK
260 270 280 290 300
RCRKPKVTQL YKCRFFSGEW SEFCKLVLSS EKLFVKYDLI LTSETIYNPD
310 320 330 340 350
YYSNLHQTFL RLLSKNGRVL LASKAHYFGV GGGVHLFQKF VEERDVFKTR
360 370
ILKIIDEGLK RFIIEITFKF PG
Length:372
Mass (Da):42,148
Last modified:May 1, 1999 - v1
Checksum:i3F0C1599035BA8B1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02708710E → D. Corresponds to variant dbSNP:rs10489177Ensembl.1
Natural variantiVAR_054050309F → L. Corresponds to variant dbSNP:rs34396097Ensembl.1
Natural variantiVAR_054051318R → H. Corresponds to variant dbSNP:rs35984232Ensembl.1
Natural variantiVAR_027088325A → V. Corresponds to variant dbSNP:rs16862686Ensembl.1
Natural variantiVAR_027089360K → M. Corresponds to variant dbSNP:rs13375701Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY744366 mRNA Translation: AAU95377.1
AL035369 mRNA Translation: CAA23019.1
CR450330 mRNA Translation: CAG29326.1
AK313909 mRNA Translation: BAG36632.1
AL021940 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90861.1
BC008679 mRNA Translation: AAH08679.1
CCDSiCCDS1284.1
RefSeqiNP_001307128.1, NM_001320199.1
NP_001307130.1, NM_001320201.1
NP_219486.1, NM_033418.3
XP_006711690.1, XM_006711627.3
UniGeneiHs.33922

Genome annotation databases

EnsembliENST00000303469; ENSP00000307077; ENSG00000171806
ENST00000310392; ENSP00000307975; ENSG00000171806
GeneIDi92342
KEGGihsa:92342
UCSCiuc001ggn.6 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMET18_HUMAN
AccessioniPrimary (citable) accession number: O95568
Secondary accession number(s): B2R9T5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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