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Protein

Histidine protein methyltransferase 1 homolog

Gene

METTL18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable histidine methyltransferase.By similarity

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB
  • methyltransferase activity Source: UniProtKB-KW

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine protein methyltransferase 1 homolog (EC:2.1.1.-)
Alternative name(s):
Arsenic-transactivated protein 2
Short name:
AsTP2
Methyltransferase-like protein 18
Gene namesi
Name:METTL18
Synonyms:ASTP2, C1orf156
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000171806.11.
HGNCiHGNC:28793. METTL18.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi92342.
OpenTargetsiENSG00000171806.
PharmGKBiPA142672407.

Polymorphism and mutation databases

BioMutaiMETTL18.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002471991 – 372Histidine protein methyltransferase 1 homologAdd BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95568.
MaxQBiO95568.
PaxDbiO95568.
PeptideAtlasiO95568.
PRIDEiO95568.

PTM databases

iPTMnetiO95568.
PhosphoSitePlusiO95568.

Expressioni

Gene expression databases

BgeeiENSG00000171806.
CleanExiHS_C1orf156.
ExpressionAtlasiO95568. baseline and differential.
GenevisibleiO95568. HS.

Organism-specific databases

HPAiHPA035314.

Interactioni

Subunit structurei

Interacts with GRWD1, RPL3 and members of the heat shock protein 90 and 70 families; these proteins may possibly be methylation substrates for the enzyme.1 Publication

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124936. 46 interactors.
IntActiO95568. 4 interactors.
MINTiMINT-3003072.
STRINGi9606.ENSP00000307077.

Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi86 – 88Combined sources3
Beta strandi92 – 94Combined sources3
Beta strandi101 – 103Combined sources3
Helixi109 – 113Combined sources5
Beta strandi116 – 120Combined sources5
Beta strandi124 – 126Combined sources3
Beta strandi130 – 138Combined sources9
Beta strandi162 – 164Combined sources3
Helixi170 – 181Combined sources12
Beta strandi190 – 194Combined sources5
Helixi200 – 207Combined sources8
Beta strandi211 – 218Combined sources8
Helixi220 – 225Combined sources6
Helixi227 – 233Combined sources7
Helixi257 – 262Combined sources6
Beta strandi263 – 268Combined sources6
Helixi270 – 278Combined sources9
Beta strandi280 – 283Combined sources4
Beta strandi287 – 294Combined sources8
Helixi299 – 301Combined sources3
Helixi302 – 312Combined sources11
Beta strandi313 – 326Combined sources14
Turni328 – 330Combined sources3
Helixi334 – 344Combined sources11
Beta strandi346 – 355Combined sources10
Beta strandi357 – 359Combined sources3
Beta strandi361 – 368Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RFQX-ray2.40A63-372[»]
ProteinModelPortaliO95568.
SMRiO95568.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2920. Eukaryota.
ENOG4111NE8. LUCA.
GeneTreeiENSGT00390000000464.
HOVERGENiHBG053309.
InParanoidiO95568.
OMAiEWSEFCK.
OrthoDBiEOG091G0J2W.
PhylomeDBiO95568.
TreeFamiTF320884.

Family and domain databases

InterProiView protein in InterPro
IPR029063. SAM-dependent_MTases.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

O95568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFQFNFTIE DHLENELTPI RDGALTLDSS KELSVSESQK GEERDRKCSA
60 70 80 90 100
EQFDLPQDHL WEHKSMENAA PSQDTDSPLS AASSSRNLEP HGKQPSLRAA
110 120 130 140 150
KEHAMPKDLK KMLENKVIET LPGFQHVKLS VVKTILLKEN FPGENIVSKS
160 170 180 190 200
FSSHSDLITG VYEGGLKIWE CTFDLLAYFT KAKVKFAGKK VLDLGCGSGL
210 220 230 240 250
LGITAFKGGS KEIHFQDYNS MVIDEVTLPN VVANSTLEDE ENDVNEPDVK
260 270 280 290 300
RCRKPKVTQL YKCRFFSGEW SEFCKLVLSS EKLFVKYDLI LTSETIYNPD
310 320 330 340 350
YYSNLHQTFL RLLSKNGRVL LASKAHYFGV GGGVHLFQKF VEERDVFKTR
360 370
ILKIIDEGLK RFIIEITFKF PG
Length:372
Mass (Da):42,148
Last modified:May 1, 1999 - v1
Checksum:i3F0C1599035BA8B1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02708710E → D. Corresponds to variant dbSNP:rs10489177Ensembl.1
Natural variantiVAR_054050309F → L. Corresponds to variant dbSNP:rs34396097Ensembl.1
Natural variantiVAR_054051318R → H. Corresponds to variant dbSNP:rs35984232Ensembl.1
Natural variantiVAR_027088325A → V. Corresponds to variant dbSNP:rs16862686Ensembl.1
Natural variantiVAR_027089360K → M. Corresponds to variant dbSNP:rs13375701Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY744366 mRNA. Translation: AAU95377.1.
AL035369 mRNA. Translation: CAA23019.1.
CR450330 mRNA. Translation: CAG29326.1.
AK313909 mRNA. Translation: BAG36632.1.
AL021940 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW90861.1.
BC008679 mRNA. Translation: AAH08679.1.
CCDSiCCDS1284.1.
RefSeqiNP_001307128.1. NM_001320199.1.
NP_001307130.1. NM_001320201.1.
NP_219486.1. NM_033418.3.
XP_006711690.1. XM_006711627.3.
UniGeneiHs.33922.

Genome annotation databases

EnsembliENST00000303469; ENSP00000307077; ENSG00000171806.
ENST00000310392; ENSP00000307975; ENSG00000171806.
GeneIDi92342.
KEGGihsa:92342.
UCSCiuc001ggn.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMET18_HUMAN
AccessioniPrimary (citable) accession number: O95568
Secondary accession number(s): B2R9T5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 1, 1999
Last modified: September 27, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families