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O95568

- MET18_HUMAN

UniProt

O95568 - MET18_HUMAN

Protein

Histidine protein methyltransferase 1 homolog

Gene

METTL18

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Probable histidine methyltransferase.By similarity

    GO - Molecular functioni

    1. protein methyltransferase activity Source: InterPro

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidine protein methyltransferase 1 homolog (EC:2.1.1.-)
    Alternative name(s):
    Arsenic-transactivated protein 2
    Short name:
    AsTP2
    Methyltransferase-like protein 18
    Gene namesi
    Name:METTL18
    Synonyms:ASTP2, C1orf156
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:28793. METTL18.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672407.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372Histidine protein methyltransferase 1 homologPRO_0000247199Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei72 – 721Phosphoserine1 Publication
    Modified residuei77 – 771Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO95568.
    PaxDbiO95568.
    PRIDEiO95568.

    PTM databases

    PhosphoSiteiO95568.

    Expressioni

    Gene expression databases

    ArrayExpressiO95568.
    BgeeiO95568.
    CleanExiHS_C1orf156.
    GenevestigatoriO95568.

    Organism-specific databases

    HPAiHPA035314.

    Interactioni

    Subunit structurei

    Interacts with GRWD1, RPL3 and members of the heat shock protein 90 and 70 families; these proteins may possibly be methylation substrates for the enzyme.1 Publication

    Protein-protein interaction databases

    BioGridi124936. 45 interactions.
    IntActiO95568. 4 interactions.
    MINTiMINT-3003072.
    STRINGi9606.ENSP00000307077.

    Structurei

    3D structure databases

    ProteinModelPortaliO95568.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG274683.
    HOVERGENiHBG053309.
    InParanoidiO95568.
    OMAiRYAQVEE.
    OrthoDBiEOG7VQJF8.
    PhylomeDBiO95568.
    TreeFamiTF320884.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR019410. Nicotinamide_N-MeTfrase-like.
    IPR010456. Ribosomal-L11_MeTrfase_PrmA.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF10294. Methyltransf_16. 1 hit.
    PF06325. PrmA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O95568-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTFQFNFTIE DHLENELTPI RDGALTLDSS KELSVSESQK GEERDRKCSA    50
    EQFDLPQDHL WEHKSMENAA PSQDTDSPLS AASSSRNLEP HGKQPSLRAA 100
    KEHAMPKDLK KMLENKVIET LPGFQHVKLS VVKTILLKEN FPGENIVSKS 150
    FSSHSDLITG VYEGGLKIWE CTFDLLAYFT KAKVKFAGKK VLDLGCGSGL 200
    LGITAFKGGS KEIHFQDYNS MVIDEVTLPN VVANSTLEDE ENDVNEPDVK 250
    RCRKPKVTQL YKCRFFSGEW SEFCKLVLSS EKLFVKYDLI LTSETIYNPD 300
    YYSNLHQTFL RLLSKNGRVL LASKAHYFGV GGGVHLFQKF VEERDVFKTR 350
    ILKIIDEGLK RFIIEITFKF PG 372
    Length:372
    Mass (Da):42,148
    Last modified:May 1, 1999 - v1
    Checksum:i3F0C1599035BA8B1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101E → D.
    Corresponds to variant rs10489177 [ dbSNP | Ensembl ].
    VAR_027087
    Natural varianti309 – 3091F → L.
    Corresponds to variant rs34396097 [ dbSNP | Ensembl ].
    VAR_054050
    Natural varianti318 – 3181R → H.
    Corresponds to variant rs35984232 [ dbSNP | Ensembl ].
    VAR_054051
    Natural varianti325 – 3251A → V.
    Corresponds to variant rs16862686 [ dbSNP | Ensembl ].
    VAR_027088
    Natural varianti360 – 3601K → M.
    Corresponds to variant rs13375701 [ dbSNP | Ensembl ].
    VAR_027089

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY744366 mRNA. Translation: AAU95377.1.
    AL035369 mRNA. Translation: CAA23019.1.
    CR450330 mRNA. Translation: CAG29326.1.
    AK313909 mRNA. Translation: BAG36632.1.
    AL021940 Genomic DNA. Translation: CAI19361.1.
    CH471067 Genomic DNA. Translation: EAW90861.1.
    BC008679 mRNA. Translation: AAH08679.1.
    CCDSiCCDS1284.1.
    RefSeqiNP_219486.1. NM_033418.2.
    XP_005245663.1. XM_005245606.2.
    XP_006711690.1. XM_006711627.1.
    UniGeneiHs.33922.

    Genome annotation databases

    EnsembliENST00000303469; ENSP00000307077; ENSG00000171806.
    ENST00000310392; ENSP00000307975; ENSG00000171806.
    GeneIDi92342.
    KEGGihsa:92342.
    UCSCiuc001ggn.4. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY744366 mRNA. Translation: AAU95377.1 .
    AL035369 mRNA. Translation: CAA23019.1 .
    CR450330 mRNA. Translation: CAG29326.1 .
    AK313909 mRNA. Translation: BAG36632.1 .
    AL021940 Genomic DNA. Translation: CAI19361.1 .
    CH471067 Genomic DNA. Translation: EAW90861.1 .
    BC008679 mRNA. Translation: AAH08679.1 .
    CCDSi CCDS1284.1.
    RefSeqi NP_219486.1. NM_033418.2.
    XP_005245663.1. XM_005245606.2.
    XP_006711690.1. XM_006711627.1.
    UniGenei Hs.33922.

    3D structure databases

    ProteinModelPortali O95568.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124936. 45 interactions.
    IntActi O95568. 4 interactions.
    MINTi MINT-3003072.
    STRINGi 9606.ENSP00000307077.

    PTM databases

    PhosphoSitei O95568.

    Proteomic databases

    MaxQBi O95568.
    PaxDbi O95568.
    PRIDEi O95568.

    Protocols and materials databases

    DNASUi 92342.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303469 ; ENSP00000307077 ; ENSG00000171806 .
    ENST00000310392 ; ENSP00000307975 ; ENSG00000171806 .
    GeneIDi 92342.
    KEGGi hsa:92342.
    UCSCi uc001ggn.4. human.

    Organism-specific databases

    CTDi 92342.
    GeneCardsi GC01M169762.
    HGNCi HGNC:28793. METTL18.
    HPAi HPA035314.
    MIMi 615255. gene.
    neXtProti NX_O95568.
    PharmGKBi PA142672407.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG274683.
    HOVERGENi HBG053309.
    InParanoidi O95568.
    OMAi RYAQVEE.
    OrthoDBi EOG7VQJF8.
    PhylomeDBi O95568.
    TreeFami TF320884.

    Miscellaneous databases

    GenomeRNAii 92342.
    NextBioi 77711.
    PROi O95568.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95568.
    Bgeei O95568.
    CleanExi HS_C1orf156.
    Genevestigatori O95568.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR019410. Nicotinamide_N-MeTfrase-like.
    IPR010456. Ribosomal-L11_MeTrfase_PrmA.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF10294. Methyltransf_16. 1 hit.
    PF06325. PrmA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and identification of human AsTP2 gene transactivated by arsenic trioxide."
      Wu S.-H., Cheng J., Zheng Y.-J., Liu Y., Zhang Y.-X.
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Rhodes S.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Subthalamic nucleus.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity."
      Cloutier P., Lavallee-Adam M., Faubert D., Blanchette M., Coulombe B.
      PLoS Genet. 9:E1003210-E1003210(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GRWD1; RPL3; HSP70 AND HSP90 FAMILY MEMBERS.

    Entry informationi

    Entry nameiMET18_HUMAN
    AccessioniPrimary (citable) accession number: O95568
    Secondary accession number(s): B2R9T5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3