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O95563

- MPC2_HUMAN

UniProt

O95563 - MPC2_HUMAN

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Protein
Mitochondrial pyruvate carrier 2
Gene
MPC2, BRP44
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the uptake of pyruvate into mitochondria.1 Publication

GO - Molecular functioni

  1. pyruvate transmembrane transporter activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. cellular metabolic process Source: Reactome
  2. mitochondrial pyruvate transport Source: Ensembl
  3. pyruvate metabolic process Source: Reactome
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_2071. Pyruvate metabolism.

Protein family/group databases

TCDBi2.A.105.1.2. the mitochondrial pyruvate carrier (mpc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial pyruvate carrier 2
Alternative name(s):
Brain protein 44
Gene namesi
Name:MPC2
Synonyms:BRP44
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:24515. MPC2.

Subcellular locationi

Mitochondrion inner membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 6121Helical; Reviewed prediction
Add
BLAST
Transmembranei73 – 9018Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: LIFEdb
  4. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672547.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127Mitochondrial pyruvate carrier 2
PRO_0000212793Add
BLAST

Proteomic databases

MaxQBiO95563.
PaxDbiO95563.
PRIDEiO95563.

PTM databases

PhosphoSiteiO95563.

Expressioni

Gene expression databases

ArrayExpressiO95563.
BgeeiO95563.
CleanExiHS_BRP44.
GenevestigatoriO95563.

Organism-specific databases

HPAiHPA056091.

Interactioni

Subunit structurei

The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2 By similarity.

Protein-protein interaction databases

BioGridi117389. 4 interactions.
IntActiO95563. 1 interaction.
MINTiMINT-3003059.

Structurei

3D structure databases

ProteinModelPortaliO95563.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG250420.
HOGENOMiHOG000188910.
HOVERGENiHBG023934.
InParanoidiO95563.
OMAiTHRVENI.
OrthoDBiEOG7W155Q.
PhylomeDBiO95563.
TreeFamiTF300066.

Family and domain databases

InterProiIPR005336. MPC.
[Graphical view]
PfamiPF03650. MPC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95563-1 [UniParc]FASTAAdd to Basket

« Hide

MSAAGARGLR ATYHRLLDKV ELMLPEKLRP LYNHPAGPRT VFFWAPIMKW    50
GLVCAGLADM ARPAEKLSTA QSAVLMATGF IWSRYSLVII PKNWSLFAVN 100
FFVGAAGASQ LFRIWRYNQE LKAKAHK 127
Length:127
Mass (Da):14,279
Last modified:May 1, 1999 - v1
Checksum:iD82E5879AB2EEA68
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035304 mRNA. Translation: CAA22909.1.
AL110297 mRNA. Translation: CAB53738.1.
AK290126 mRNA. Translation: BAF82815.1.
CR407632 mRNA. Translation: CAG28560.1.
CR533473 mRNA. Translation: CAG38504.1.
Z97876 Genomic DNA. Translation: CAI20075.1.
CH471067 Genomic DNA. Translation: EAW90814.1.
BC104157 mRNA. Translation: AAI04158.1.
BC104158 mRNA. Translation: AAI04159.1.
CCDSiCCDS1266.1.
PIRiT14797.
RefSeqiNP_001137146.1. NM_001143674.3.
NP_056230.1. NM_015415.3.
XP_006711329.1. XM_006711266.1.
UniGeneiHs.517768.

Genome annotation databases

EnsembliENST00000271373; ENSP00000271373; ENSG00000143158.
ENST00000367846; ENSP00000356820; ENSG00000143158.
GeneIDi25874.
KEGGihsa:25874.
UCSCiuc001ges.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035304 mRNA. Translation: CAA22909.1 .
AL110297 mRNA. Translation: CAB53738.1 .
AK290126 mRNA. Translation: BAF82815.1 .
CR407632 mRNA. Translation: CAG28560.1 .
CR533473 mRNA. Translation: CAG38504.1 .
Z97876 Genomic DNA. Translation: CAI20075.1 .
CH471067 Genomic DNA. Translation: EAW90814.1 .
BC104157 mRNA. Translation: AAI04158.1 .
BC104158 mRNA. Translation: AAI04159.1 .
CCDSi CCDS1266.1.
PIRi T14797.
RefSeqi NP_001137146.1. NM_001143674.3.
NP_056230.1. NM_015415.3.
XP_006711329.1. XM_006711266.1.
UniGenei Hs.517768.

3D structure databases

ProteinModelPortali O95563.
ModBasei Search...

Protein-protein interaction databases

BioGridi 117389. 4 interactions.
IntActi O95563. 1 interaction.
MINTi MINT-3003059.

Protein family/group databases

TCDBi 2.A.105.1.2. the mitochondrial pyruvate carrier (mpc) family.

PTM databases

PhosphoSitei O95563.

Proteomic databases

MaxQBi O95563.
PaxDbi O95563.
PRIDEi O95563.

Protocols and materials databases

DNASUi 25874.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000271373 ; ENSP00000271373 ; ENSG00000143158 .
ENST00000367846 ; ENSP00000356820 ; ENSG00000143158 .
GeneIDi 25874.
KEGGi hsa:25874.
UCSCi uc001ges.3. human.

Organism-specific databases

CTDi 25874.
GeneCardsi GC01M167886.
HGNCi HGNC:24515. MPC2.
HPAi HPA056091.
MIMi 614737. gene.
neXtProti NX_O95563.
PharmGKBi PA142672547.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG250420.
HOGENOMi HOG000188910.
HOVERGENi HBG023934.
InParanoidi O95563.
OMAi THRVENI.
OrthoDBi EOG7W155Q.
PhylomeDBi O95563.
TreeFami TF300066.

Enzyme and pathway databases

Reactomei REACT_2071. Pyruvate metabolism.

Miscellaneous databases

GeneWikii BRP44.
GenomeRNAii 25874.
NextBioi 47274.
PROi O95563.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95563.
Bgeei O95563.
CleanExi HS_BRP44.
Genevestigatori O95563.

Family and domain databases

InterProi IPR005336. MPC.
[Graphical view ]
Pfami PF03650. MPC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Rhodes S.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiMPC2_HUMAN
AccessioniPrimary (citable) accession number: O95563
Secondary accession number(s): A8K261, Q3SXR6, Q6FIF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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