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Protein

Mitochondrial pyruvate carrier 2

Gene

MPC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the uptake of pyruvate into mitochondria.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-70268 Pyruvate metabolism

Protein family/group databases

TCDBi2.A.105.1.2 the mitochondrial pyruvate carrier (mpc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial pyruvate carrier 2
Alternative name(s):
Brain protein 44
Gene namesi
Name:MPC2
Synonyms:BRP44
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143158.10
HGNCiHGNC:24515 MPC2
MIMi614737 gene
neXtProtiNX_O95563

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei73 – 90HelicalSequence analysisAdd BLAST18
Transmembranei96 – 115HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi25874
OpenTargetsiENSG00000143158
PharmGKBiPA142672547

Polymorphism and mutation databases

BioMutaiMPC2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002127931 – 127Mitochondrial pyruvate carrier 2Add BLAST127

Proteomic databases

EPDiO95563
MaxQBiO95563
PaxDbiO95563
PeptideAtlasiO95563
PRIDEiO95563
TopDownProteomicsiO95563

PTM databases

iPTMnetiO95563
PhosphoSitePlusiO95563

Expressioni

Gene expression databases

BgeeiENSG00000143158
CleanExiHS_BRP44
ExpressionAtlasiO95563 baseline and differential
GenevisibleiO95563 HS

Organism-specific databases

HPAiHPA056091

Interactioni

Subunit structurei

The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2.By similarity

Protein-protein interaction databases

BioGridi117389, 14 interactors
IntActiO95563, 11 interactors
STRINGi9606.ENSP00000271373

Structurei

3D structure databases

ProteinModelPortaliO95563
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1589 Eukaryota
ENOG4111UER LUCA
GeneTreeiENSGT00510000047120
HOGENOMiHOG000188910
HOVERGENiHBG023934
InParanoidiO95563
KOiK22139
OMAiSQLYRIW
OrthoDBiEOG091G0XXH
PhylomeDBiO95563
TreeFamiTF300066

Family and domain databases

InterProiView protein in InterPro
IPR005336 MPC
PfamiView protein in Pfam
PF03650 MPC, 1 hit

Sequencei

Sequence statusi: Complete.

O95563-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAGARGLR ATYHRLLDKV ELMLPEKLRP LYNHPAGPRT VFFWAPIMKW
60 70 80 90 100
GLVCAGLADM ARPAEKLSTA QSAVLMATGF IWSRYSLVII PKNWSLFAVN
110 120
FFVGAAGASQ LFRIWRYNQE LKAKAHK
Length:127
Mass (Da):14,279
Last modified:May 1, 1999 - v1
Checksum:iD82E5879AB2EEA68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035304 mRNA Translation: CAA22909.1
AL110297 mRNA Translation: CAB53738.1
AK290126 mRNA Translation: BAF82815.1
CR407632 mRNA Translation: CAG28560.1
CR533473 mRNA Translation: CAG38504.1
Z97876 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90814.1
BC104157 mRNA Translation: AAI04158.1
BC104158 mRNA Translation: AAI04159.1
CCDSiCCDS1266.1
PIRiT14797
RefSeqiNP_001137146.1, NM_001143674.3
NP_056230.1, NM_015415.3
XP_006711329.1, XM_006711266.3
UniGeneiHs.517768

Genome annotation databases

EnsembliENST00000271373; ENSP00000271373; ENSG00000143158
ENST00000367846; ENSP00000356820; ENSG00000143158
GeneIDi25874
KEGGihsa:25874
UCSCiuc001ges.4 human

Similar proteinsi

Entry informationi

Entry nameiMPC2_HUMAN
AccessioniPrimary (citable) accession number: O95563
Secondary accession number(s): A8K261, Q3SXR6, Q6FIF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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