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O95563

- MPC2_HUMAN

UniProt

O95563 - MPC2_HUMAN

Protein

Mitochondrial pyruvate carrier 2

Gene

MPC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Mediates the uptake of pyruvate into mitochondria.1 Publication

    GO - Molecular functioni

    1. pyruvate transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. cellular metabolic process Source: Reactome
    2. mitochondrial pyruvate transport Source: Ensembl
    3. pyruvate metabolic process Source: Reactome
    4. small molecule metabolic process Source: Reactome

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_2071. Pyruvate metabolism.

    Protein family/group databases

    TCDBi2.A.105.1.2. the mitochondrial pyruvate carrier (mpc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial pyruvate carrier 2
    Alternative name(s):
    Brain protein 44
    Gene namesi
    Name:MPC2
    Synonyms:BRP44
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:24515. MPC2.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. mitochondrion Source: LIFEdb
    4. nucleus Source: UniProt

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672547.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 127127Mitochondrial pyruvate carrier 2PRO_0000212793Add
    BLAST

    Proteomic databases

    MaxQBiO95563.
    PaxDbiO95563.
    PRIDEiO95563.

    PTM databases

    PhosphoSiteiO95563.

    Expressioni

    Gene expression databases

    ArrayExpressiO95563.
    BgeeiO95563.
    CleanExiHS_BRP44.
    GenevestigatoriO95563.

    Organism-specific databases

    HPAiHPA056091.

    Interactioni

    Subunit structurei

    The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2.By similarity

    Protein-protein interaction databases

    BioGridi117389. 4 interactions.
    IntActiO95563. 1 interaction.
    MINTiMINT-3003059.

    Structurei

    3D structure databases

    ProteinModelPortaliO95563.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei73 – 9018HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG250420.
    HOGENOMiHOG000188910.
    HOVERGENiHBG023934.
    InParanoidiO95563.
    OMAiTHRVENI.
    OrthoDBiEOG7W155Q.
    PhylomeDBiO95563.
    TreeFamiTF300066.

    Family and domain databases

    InterProiIPR005336. MPC.
    [Graphical view]
    PfamiPF03650. MPC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95563-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAAGARGLR ATYHRLLDKV ELMLPEKLRP LYNHPAGPRT VFFWAPIMKW    50
    GLVCAGLADM ARPAEKLSTA QSAVLMATGF IWSRYSLVII PKNWSLFAVN 100
    FFVGAAGASQ LFRIWRYNQE LKAKAHK 127
    Length:127
    Mass (Da):14,279
    Last modified:May 1, 1999 - v1
    Checksum:iD82E5879AB2EEA68
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035304 mRNA. Translation: CAA22909.1.
    AL110297 mRNA. Translation: CAB53738.1.
    AK290126 mRNA. Translation: BAF82815.1.
    CR407632 mRNA. Translation: CAG28560.1.
    CR533473 mRNA. Translation: CAG38504.1.
    Z97876 Genomic DNA. Translation: CAI20075.1.
    CH471067 Genomic DNA. Translation: EAW90814.1.
    BC104157 mRNA. Translation: AAI04158.1.
    BC104158 mRNA. Translation: AAI04159.1.
    CCDSiCCDS1266.1.
    PIRiT14797.
    RefSeqiNP_001137146.1. NM_001143674.3.
    NP_056230.1. NM_015415.3.
    XP_006711329.1. XM_006711266.1.
    UniGeneiHs.517768.

    Genome annotation databases

    EnsembliENST00000271373; ENSP00000271373; ENSG00000143158.
    ENST00000367846; ENSP00000356820; ENSG00000143158.
    GeneIDi25874.
    KEGGihsa:25874.
    UCSCiuc001ges.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035304 mRNA. Translation: CAA22909.1 .
    AL110297 mRNA. Translation: CAB53738.1 .
    AK290126 mRNA. Translation: BAF82815.1 .
    CR407632 mRNA. Translation: CAG28560.1 .
    CR533473 mRNA. Translation: CAG38504.1 .
    Z97876 Genomic DNA. Translation: CAI20075.1 .
    CH471067 Genomic DNA. Translation: EAW90814.1 .
    BC104157 mRNA. Translation: AAI04158.1 .
    BC104158 mRNA. Translation: AAI04159.1 .
    CCDSi CCDS1266.1.
    PIRi T14797.
    RefSeqi NP_001137146.1. NM_001143674.3.
    NP_056230.1. NM_015415.3.
    XP_006711329.1. XM_006711266.1.
    UniGenei Hs.517768.

    3D structure databases

    ProteinModelPortali O95563.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117389. 4 interactions.
    IntActi O95563. 1 interaction.
    MINTi MINT-3003059.

    Protein family/group databases

    TCDBi 2.A.105.1.2. the mitochondrial pyruvate carrier (mpc) family.

    PTM databases

    PhosphoSitei O95563.

    Proteomic databases

    MaxQBi O95563.
    PaxDbi O95563.
    PRIDEi O95563.

    Protocols and materials databases

    DNASUi 25874.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000271373 ; ENSP00000271373 ; ENSG00000143158 .
    ENST00000367846 ; ENSP00000356820 ; ENSG00000143158 .
    GeneIDi 25874.
    KEGGi hsa:25874.
    UCSCi uc001ges.3. human.

    Organism-specific databases

    CTDi 25874.
    GeneCardsi GC01M167886.
    HGNCi HGNC:24515. MPC2.
    HPAi HPA056091.
    MIMi 614737. gene.
    neXtProti NX_O95563.
    PharmGKBi PA142672547.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG250420.
    HOGENOMi HOG000188910.
    HOVERGENi HBG023934.
    InParanoidi O95563.
    OMAi THRVENI.
    OrthoDBi EOG7W155Q.
    PhylomeDBi O95563.
    TreeFami TF300066.

    Enzyme and pathway databases

    Reactomei REACT_2071. Pyruvate metabolism.

    Miscellaneous databases

    GeneWikii BRP44.
    GenomeRNAii 25874.
    NextBioi 47274.
    PROi O95563.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95563.
    Bgeei O95563.
    CleanExi HS_BRP44.
    Genevestigatori O95563.

    Family and domain databases

    InterProi IPR005336. MPC.
    [Graphical view ]
    Pfami PF03650. MPC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Rhodes S.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thalamus.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiMPC2_HUMAN
    AccessioniPrimary (citable) accession number: O95563
    Secondary accession number(s): A8K261, Q3SXR6, Q6FIF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3