Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial pyruvate carrier 2

Gene

MPC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the uptake of pyruvate into mitochondria.1 Publication

GO - Molecular functioni

  1. pyruvate transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. cellular metabolic process Source: Reactome
  2. mitochondrial pyruvate transport Source: Ensembl
  3. pyruvate metabolic process Source: Reactome
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_2071. Pyruvate metabolism.

Protein family/group databases

TCDBi2.A.105.1.2. the mitochondrial pyruvate carrier (mpc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial pyruvate carrier 2
Alternative name(s):
Brain protein 44
Gene namesi
Name:MPC2
Synonyms:BRP44
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:24515. MPC2.

Subcellular locationi

Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 6121HelicalSequence AnalysisAdd
BLAST
Transmembranei73 – 9018HelicalSequence AnalysisAdd
BLAST
Transmembranei96 – 11520HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: LIFEdb
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672547.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127Mitochondrial pyruvate carrier 2PRO_0000212793Add
BLAST

Proteomic databases

MaxQBiO95563.
PaxDbiO95563.
PRIDEiO95563.

PTM databases

PhosphoSiteiO95563.

Expressioni

Gene expression databases

BgeeiO95563.
CleanExiHS_BRP44.
ExpressionAtlasiO95563. baseline and differential.
GenevestigatoriO95563.

Organism-specific databases

HPAiHPA056091.

Interactioni

Subunit structurei

The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2.By similarity

Protein-protein interaction databases

BioGridi117389. 4 interactions.
IntActiO95563. 1 interaction.
MINTiMINT-3003059.

Structurei

3D structure databases

ProteinModelPortaliO95563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG250420.
GeneTreeiENSGT00510000047120.
HOGENOMiHOG000188910.
HOVERGENiHBG023934.
InParanoidiO95563.
OMAiGAIWTRY.
OrthoDBiEOG7W155Q.
PhylomeDBiO95563.
TreeFamiTF300066.

Family and domain databases

InterProiIPR005336. MPC.
[Graphical view]
PfamiPF03650. MPC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95563-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAAGARGLR ATYHRLLDKV ELMLPEKLRP LYNHPAGPRT VFFWAPIMKW
60 70 80 90 100
GLVCAGLADM ARPAEKLSTA QSAVLMATGF IWSRYSLVII PKNWSLFAVN
110 120
FFVGAAGASQ LFRIWRYNQE LKAKAHK
Length:127
Mass (Da):14,279
Last modified:May 1, 1999 - v1
Checksum:iD82E5879AB2EEA68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035304 mRNA. Translation: CAA22909.1.
AL110297 mRNA. Translation: CAB53738.1.
AK290126 mRNA. Translation: BAF82815.1.
CR407632 mRNA. Translation: CAG28560.1.
CR533473 mRNA. Translation: CAG38504.1.
Z97876 Genomic DNA. Translation: CAI20075.1.
CH471067 Genomic DNA. Translation: EAW90814.1.
BC104157 mRNA. Translation: AAI04158.1.
BC104158 mRNA. Translation: AAI04159.1.
CCDSiCCDS1266.1.
PIRiT14797.
RefSeqiNP_001137146.1. NM_001143674.3.
NP_056230.1. NM_015415.3.
XP_006711329.1. XM_006711266.1.
UniGeneiHs.517768.

Genome annotation databases

EnsembliENST00000271373; ENSP00000271373; ENSG00000143158.
ENST00000367846; ENSP00000356820; ENSG00000143158.
GeneIDi25874.
KEGGihsa:25874.
UCSCiuc001ges.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035304 mRNA. Translation: CAA22909.1.
AL110297 mRNA. Translation: CAB53738.1.
AK290126 mRNA. Translation: BAF82815.1.
CR407632 mRNA. Translation: CAG28560.1.
CR533473 mRNA. Translation: CAG38504.1.
Z97876 Genomic DNA. Translation: CAI20075.1.
CH471067 Genomic DNA. Translation: EAW90814.1.
BC104157 mRNA. Translation: AAI04158.1.
BC104158 mRNA. Translation: AAI04159.1.
CCDSiCCDS1266.1.
PIRiT14797.
RefSeqiNP_001137146.1. NM_001143674.3.
NP_056230.1. NM_015415.3.
XP_006711329.1. XM_006711266.1.
UniGeneiHs.517768.

3D structure databases

ProteinModelPortaliO95563.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117389. 4 interactions.
IntActiO95563. 1 interaction.
MINTiMINT-3003059.

Protein family/group databases

TCDBi2.A.105.1.2. the mitochondrial pyruvate carrier (mpc) family.

PTM databases

PhosphoSiteiO95563.

Proteomic databases

MaxQBiO95563.
PaxDbiO95563.
PRIDEiO95563.

Protocols and materials databases

DNASUi25874.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271373; ENSP00000271373; ENSG00000143158.
ENST00000367846; ENSP00000356820; ENSG00000143158.
GeneIDi25874.
KEGGihsa:25874.
UCSCiuc001ges.3. human.

Organism-specific databases

CTDi25874.
GeneCardsiGC01M167886.
HGNCiHGNC:24515. MPC2.
HPAiHPA056091.
MIMi614737. gene.
neXtProtiNX_O95563.
PharmGKBiPA142672547.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG250420.
GeneTreeiENSGT00510000047120.
HOGENOMiHOG000188910.
HOVERGENiHBG023934.
InParanoidiO95563.
OMAiGAIWTRY.
OrthoDBiEOG7W155Q.
PhylomeDBiO95563.
TreeFamiTF300066.

Enzyme and pathway databases

ReactomeiREACT_2071. Pyruvate metabolism.

Miscellaneous databases

GeneWikiiBRP44.
GenomeRNAii25874.
NextBioi47274.
PROiO95563.
SOURCEiSearch...

Gene expression databases

BgeeiO95563.
CleanExiHS_BRP44.
ExpressionAtlasiO95563. baseline and differential.
GenevestigatoriO95563.

Family and domain databases

InterProiIPR005336. MPC.
[Graphical view]
PfamiPF03650. MPC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Rhodes S.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiMPC2_HUMAN
AccessioniPrimary (citable) accession number: O95563
Secondary accession number(s): A8K261, Q3SXR6, Q6FIF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 1999
Last modified: January 7, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.