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Protein

Vesicle transport protein SFT2B

Gene

SFT2D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport protein SFT2B
Alternative name(s):
SFT2 domain-containing protein 2
Gene namesi
Name:SFT2D2Imported
ORF Names:UNQ512/PRO1027
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000213064.9
HGNCiHGNC:25140 SFT2D2
neXtProtiNX_O95562

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini58 – 63LumenalSequence analysis6
Transmembranei64 – 84Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini85 – 98CytoplasmicSequence analysisAdd BLAST14
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 123LumenalSequence analysis4
Transmembranei124 – 144Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini145 – 160CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi375035
OpenTargetsiENSG00000213064
PharmGKBiPA142670928

Polymorphism and mutation databases

BioMutaiSFT2D2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002386101 – 160Vesicle transport protein SFT2BAdd BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei9PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95562
MaxQBiO95562
PaxDbiO95562
PeptideAtlasiO95562
PRIDEiO95562

PTM databases

iPTMnetiO95562
PhosphoSitePlusiO95562
SwissPalmiO95562

Expressioni

Gene expression databases

BgeeiENSG00000213064
CleanExiHS_SFT2D2
ExpressionAtlasiO95562 baseline and differential
GenevisibleiO95562 HS

Organism-specific databases

HPAiHPA042207

Interactioni

Protein-protein interaction databases

BioGridi131951, 4 interactors
STRINGi9606.ENSP00000271375

Structurei

3D structure databases

ProteinModelPortaliO95562
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SFT2 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2887 Eukaryota
COG5102 LUCA
GeneTreeiENSGT00390000018525
HOGENOMiHOG000017959
HOVERGENiHBG053306
InParanoidiO95562
OMAiCEICALI
OrthoDBiEOG091G0UCR
PhylomeDBiO95562
TreeFamiTF315157

Family and domain databases

InterProiView protein in InterPro
IPR007305 Vesicle_transpt_Got1/SFT2
IPR011691 Vesicle_transpt_SFT2
PANTHERiPTHR23137 PTHR23137, 1 hit
PfamiView protein in Pfam
PF04178 Got1, 1 hit

Sequencei

Sequence statusi: Complete.

O95562-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLKKVLSG QDTEDRSGLS EVVEASSLSW STRIKGFIAC FAIGILCSLL
60 70 80 90 100
GTVLLWVPRK GLHLFAVFYT FGNIASIGST IFLMGPVKQL KRMFEPTRLI
110 120 130 140 150
ATIMVLLCFA LTLCSAFWWH NKGLALIFCI LQSLALTWYS LSFIPFARDA
160
VKKCFAVCLA
Length:160
Mass (Da):17,779
Last modified:May 1, 1999 - v1
Checksum:iF05C57532B7593BD
GO

Sequence cautioni

The sequence AAQ89038 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035297 mRNA Translation: CAA22897.1
AK290325 mRNA Translation: BAF83014.1
AL009051 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90822.1
BC068098 mRNA Translation: AAH68098.1
AY358675 mRNA Translation: AAQ89038.1 Different initiation.
CCDSiCCDS1271.1
RefSeqiNP_955376.1, NM_199344.2
UniGeneiHs.645435

Genome annotation databases

EnsembliENST00000271375; ENSP00000271375; ENSG00000213064
GeneIDi375035
KEGGihsa:375035
UCSCiuc001gfk.3 human

Similar proteinsi

Entry informationi

Entry nameiSFT2B_HUMAN
AccessioniPrimary (citable) accession number: O95562
Secondary accession number(s): A8K2R0, Q6UWR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health