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Protein

Vesicle transport protein SFT2B

Gene

SFT2D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport protein SFT2B
Alternative name(s):
SFT2 domain-containing protein 2
Gene namesi
Name:SFT2D2Imported
ORF Names:UNQ512/PRO1027
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25140. SFT2D2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini58 – 63LumenalSequence analysis6
Transmembranei64 – 84Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini85 – 98CytoplasmicSequence analysisAdd BLAST14
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 123LumenalSequence analysis4
Transmembranei124 – 144Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini145 – 160CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi375035.
OpenTargetsiENSG00000213064.
PharmGKBiPA142670928.

Polymorphism and mutation databases

BioMutaiSFT2D2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002386101 – 160Vesicle transport protein SFT2BAdd BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei9PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95562.
MaxQBiO95562.
PaxDbiO95562.
PeptideAtlasiO95562.
PRIDEiO95562.

PTM databases

iPTMnetiO95562.
PhosphoSitePlusiO95562.
SwissPalmiO95562.

Expressioni

Gene expression databases

BgeeiENSG00000213064.
CleanExiHS_SFT2D2.
ExpressionAtlasiO95562. baseline and differential.
GenevisibleiO95562. HS.

Organism-specific databases

HPAiHPA042207.

Interactioni

Protein-protein interaction databases

BioGridi131951. 2 interactors.
STRINGi9606.ENSP00000271375.

Structurei

3D structure databases

ProteinModelPortaliO95562.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SFT2 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2887. Eukaryota.
COG5102. LUCA.
GeneTreeiENSGT00390000018525.
HOGENOMiHOG000017959.
HOVERGENiHBG053306.
InParanoidiO95562.
OMAiFIACFAA.
OrthoDBiEOG091G0UCR.
PhylomeDBiO95562.
TreeFamiTF315157.

Family and domain databases

InterProiIPR007305. Vesicle_transpt_Got1/SFT2.
IPR011691. Vesicle_transpt_SFT2.
[Graphical view]
PANTHERiPTHR23137. PTHR23137. 1 hit.
PfamiPF04178. Got1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95562-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLKKVLSG QDTEDRSGLS EVVEASSLSW STRIKGFIAC FAIGILCSLL
60 70 80 90 100
GTVLLWVPRK GLHLFAVFYT FGNIASIGST IFLMGPVKQL KRMFEPTRLI
110 120 130 140 150
ATIMVLLCFA LTLCSAFWWH NKGLALIFCI LQSLALTWYS LSFIPFARDA
160
VKKCFAVCLA
Length:160
Mass (Da):17,779
Last modified:May 1, 1999 - v1
Checksum:iF05C57532B7593BD
GO

Sequence cautioni

The sequence AAQ89038 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035297 mRNA. Translation: CAA22897.1.
AK290325 mRNA. Translation: BAF83014.1.
AL009051 Genomic DNA. Translation: CAI22642.1.
CH471067 Genomic DNA. Translation: EAW90822.1.
BC068098 mRNA. Translation: AAH68098.1.
AY358675 mRNA. Translation: AAQ89038.1. Different initiation.
CCDSiCCDS1271.1.
RefSeqiNP_955376.1. NM_199344.2.
UniGeneiHs.645435.

Genome annotation databases

EnsembliENST00000271375; ENSP00000271375; ENSG00000213064.
GeneIDi375035.
KEGGihsa:375035.
UCSCiuc001gfk.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035297 mRNA. Translation: CAA22897.1.
AK290325 mRNA. Translation: BAF83014.1.
AL009051 Genomic DNA. Translation: CAI22642.1.
CH471067 Genomic DNA. Translation: EAW90822.1.
BC068098 mRNA. Translation: AAH68098.1.
AY358675 mRNA. Translation: AAQ89038.1. Different initiation.
CCDSiCCDS1271.1.
RefSeqiNP_955376.1. NM_199344.2.
UniGeneiHs.645435.

3D structure databases

ProteinModelPortaliO95562.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131951. 2 interactors.
STRINGi9606.ENSP00000271375.

PTM databases

iPTMnetiO95562.
PhosphoSitePlusiO95562.
SwissPalmiO95562.

Polymorphism and mutation databases

BioMutaiSFT2D2.

Proteomic databases

EPDiO95562.
MaxQBiO95562.
PaxDbiO95562.
PeptideAtlasiO95562.
PRIDEiO95562.

Protocols and materials databases

DNASUi375035.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271375; ENSP00000271375; ENSG00000213064.
GeneIDi375035.
KEGGihsa:375035.
UCSCiuc001gfk.3. human.

Organism-specific databases

CTDi375035.
DisGeNETi375035.
GeneCardsiSFT2D2.
HGNCiHGNC:25140. SFT2D2.
HPAiHPA042207.
neXtProtiNX_O95562.
OpenTargetsiENSG00000213064.
PharmGKBiPA142670928.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2887. Eukaryota.
COG5102. LUCA.
GeneTreeiENSGT00390000018525.
HOGENOMiHOG000017959.
HOVERGENiHBG053306.
InParanoidiO95562.
OMAiFIACFAA.
OrthoDBiEOG091G0UCR.
PhylomeDBiO95562.
TreeFamiTF315157.

Miscellaneous databases

GenomeRNAii375035.
PROiO95562.

Gene expression databases

BgeeiENSG00000213064.
CleanExiHS_SFT2D2.
ExpressionAtlasiO95562. baseline and differential.
GenevisibleiO95562. HS.

Family and domain databases

InterProiIPR007305. Vesicle_transpt_Got1/SFT2.
IPR011691. Vesicle_transpt_SFT2.
[Graphical view]
PANTHERiPTHR23137. PTHR23137. 1 hit.
PfamiPF04178. Got1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSFT2B_HUMAN
AccessioniPrimary (citable) accession number: O95562
Secondary accession number(s): A8K2R0, Q6UWR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.