ID   CA105_HUMAN             Reviewed;         183 AA.
AC   O95561; Q8IY02;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   24-JAN-2024, entry version 130.
DE   RecName: Full=Uncharacterized protein C1orf105;
GN   Name=C1orf105;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Rhodes S.;
RL   Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-137.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       O95561; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-10191951, EBI-744099;
CC       O95561; P45984: MAPK9; NbExp=5; IntAct=EBI-10191951, EBI-713568;
CC       O95561; O15160: POLR1C; NbExp=3; IntAct=EBI-10191951, EBI-1055079;
CC       O95561; P25788: PSMA3; NbExp=3; IntAct=EBI-10191951, EBI-348380;
CC       O95561; P0C264: SBK3; NbExp=3; IntAct=EBI-10191951, EBI-17181801;
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DR   EMBL; AL035295; CAA22895.1; -; mRNA.
DR   EMBL; Z97195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC038410; AAH38410.1; -; mRNA.
DR   CCDS; CCDS1301.1; -.
DR   RefSeq; NP_640333.3; NM_139240.3.
DR   AlphaFoldDB; O95561; -.
DR   SMR; O95561; -.
DR   BioGRID; 124939; 11.
DR   IntAct; O95561; 7.
DR   STRING; 9606.ENSP00000356700; -.
DR   iPTMnet; O95561; -.
DR   PhosphoSitePlus; O95561; -.
DR   BioMuta; C1orf105; -.
DR   PaxDb; 9606-ENSP00000356700; -.
DR   Antibodypedia; 49838; 89 antibodies from 13 providers.
DR   DNASU; 92346; -.
DR   Ensembl; ENST00000367727.9; ENSP00000356700.4; ENSG00000180999.11.
DR   GeneID; 92346; -.
DR   KEGG; hsa:92346; -.
DR   MANE-Select; ENST00000367727.9; ENSP00000356700.4; NM_139240.4; NP_640333.3.
DR   UCSC; uc001gik.3; human.
DR   AGR; HGNC:29591; -.
DR   CTD; 92346; -.
DR   DisGeNET; 92346; -.
DR   GeneCards; C1orf105; -.
DR   HGNC; HGNC:29591; C1orf105.
DR   HPA; ENSG00000180999; Tissue enhanced (heart muscle, testis).
DR   MalaCards; C1orf105; -.
DR   neXtProt; NX_O95561; -.
DR   OpenTargets; ENSG00000180999; -.
DR   PharmGKB; PA142672489; -.
DR   VEuPathDB; HostDB:ENSG00000180999; -.
DR   eggNOG; ENOG502TDU3; Eukaryota.
DR   GeneTree; ENSGT00390000015231; -.
DR   HOGENOM; CLU_1474736_0_0_1; -.
DR   InParanoid; O95561; -.
DR   OMA; RFDKIPW; -.
DR   OrthoDB; 5263031at2759; -.
DR   PhylomeDB; O95561; -.
DR   TreeFam; TF336911; -.
DR   PathwayCommons; O95561; -.
DR   SignaLink; O95561; -.
DR   BioGRID-ORCS; 92346; 10 hits in 1116 CRISPR screens.
DR   ChiTaRS; C1orf105; human.
DR   GenomeRNAi; 92346; -.
DR   Pharos; O95561; Tdark.
DR   PRO; PR:O95561; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; O95561; Protein.
DR   Bgee; ENSG00000180999; Expressed in sperm and 105 other cell types or tissues.
DR   ExpressionAtlas; O95561; baseline and differential.
DR   InterPro; IPR027845; DUF4548.
DR   PANTHER; PTHR39410; RIKEN CDNA 4930558K02 GENE; 1.
DR   PANTHER; PTHR39410:SF1; RIKEN CDNA 4930558K02 GENE; 1.
DR   Pfam; PF15081; DUF4548; 1.
DR   Genevisible; O95561; HS.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..183
FT                   /note="Uncharacterized protein C1orf105"
FT                   /id="PRO_0000251727"
FT   VARIANT         97
FT                   /note="M -> V (in dbSNP:rs16844498)"
FT                   /id="VAR_027710"
FT   VARIANT         137
FT                   /note="S -> N (in dbSNP:rs1129942)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_027711"
SQ   SEQUENCE   183 AA;  21209 MW;  665168CBB7409A30 CRC64;
     MEKRELKASV PKFDKIPWLS EASLVNKPLV LSLPRRYPHT SATFLTSSKK NMNLPILFQV
     PDVLSKARRN QCDSMLLRNQ QLCSTCQEMK MVQPRTMKIP DDPKASFENC MSYRMSLHQP
     KFQTTPEPFH DDIPTESIHY RLPILGPRTA VFHGLLTEAY KTLKERQRSS LPRKEPIGKT
     TRQ
//