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Protein

Uncharacterized protein C1orf105

Gene

C1orf105

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C1orf105
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29591. C1orf105.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672489.

Polymorphism and mutation databases

BioMutaiC1orf105.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Uncharacterized protein C1orf105PRO_0000251727Add
BLAST

Proteomic databases

PaxDbiO95561.
PRIDEiO95561.

PTM databases

PhosphoSiteiO95561.

Expressioni

Gene expression databases

BgeeiO95561.
CleanExiHS_C1orf105.
ExpressionAtlasiO95561. baseline and differential.
GenevisibleiO95561. HS.

Organism-specific databases

HPAiHPA028480.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PSMA3P257883EBI-10191951,EBI-348380

Protein-protein interaction databases

BioGridi124939. 5 interactions.
IntActiO95561. 1 interaction.
STRINGi9606.ENSP00000356700.

Structurei

3D structure databases

ProteinModelPortaliO95561.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG87534.
GeneTreeiENSGT00390000015231.
HOGENOMiHOG000111241.
HOVERGENiHBG080962.
InParanoidiO95561.
OMAiPWFSEAS.
OrthoDBiEOG7N0C60.
PhylomeDBiO95561.
TreeFamiTF336911.

Family and domain databases

InterProiIPR027845. DUF4548.
[Graphical view]
PfamiPF15081. DUF4548. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95561-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKRELKASV PKFDKIPWLS EASLVNKPLV LSLPRRYPHT SATFLTSSKK
60 70 80 90 100
NMNLPILFQV PDVLSKARRN QCDSMLLRNQ QLCSTCQEMK MVQPRTMKIP
110 120 130 140 150
DDPKASFENC MSYRMSLHQP KFQTTPEPFH DDIPTESIHY RLPILGPRTA
160 170 180
VFHGLLTEAY KTLKERQRSS LPRKEPIGKT TRQ
Length:183
Mass (Da):21,209
Last modified:May 1, 1999 - v1
Checksum:i665168CBB7409A30
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971M → V.
Corresponds to variant rs16844498 [ dbSNP | Ensembl ].
VAR_027710
Natural varianti137 – 1371S → N.1 Publication
Corresponds to variant rs1129942 [ dbSNP | Ensembl ].
VAR_027711

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035295 mRNA. Translation: CAA22895.1.
Z97195 Genomic DNA. Translation: CAI19058.1.
BC038410 mRNA. Translation: AAH38410.1.
CCDSiCCDS1301.1.
RefSeqiNP_640333.3. NM_139240.3.
UniGeneiHs.517991.

Genome annotation databases

EnsembliENST00000367727; ENSP00000356700; ENSG00000180999.
GeneIDi92346.
KEGGihsa:92346.
UCSCiuc001gik.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035295 mRNA. Translation: CAA22895.1.
Z97195 Genomic DNA. Translation: CAI19058.1.
BC038410 mRNA. Translation: AAH38410.1.
CCDSiCCDS1301.1.
RefSeqiNP_640333.3. NM_139240.3.
UniGeneiHs.517991.

3D structure databases

ProteinModelPortaliO95561.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124939. 5 interactions.
IntActiO95561. 1 interaction.
STRINGi9606.ENSP00000356700.

PTM databases

PhosphoSiteiO95561.

Polymorphism and mutation databases

BioMutaiC1orf105.

Proteomic databases

PaxDbiO95561.
PRIDEiO95561.

Protocols and materials databases

DNASUi92346.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367727; ENSP00000356700; ENSG00000180999.
GeneIDi92346.
KEGGihsa:92346.
UCSCiuc001gik.3. human.

Organism-specific databases

CTDi92346.
GeneCardsiGC01P172389.
H-InvDBHIX0023854.
HGNCiHGNC:29591. C1orf105.
HPAiHPA028480.
neXtProtiNX_O95561.
PharmGKBiPA142672489.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG87534.
GeneTreeiENSGT00390000015231.
HOGENOMiHOG000111241.
HOVERGENiHBG080962.
InParanoidiO95561.
OMAiPWFSEAS.
OrthoDBiEOG7N0C60.
PhylomeDBiO95561.
TreeFamiTF336911.

Miscellaneous databases

GenomeRNAii92346.
NextBioi77722.
PROiO95561.

Gene expression databases

BgeeiO95561.
CleanExiHS_C1orf105.
ExpressionAtlasiO95561. baseline and differential.
GenevisibleiO95561. HS.

Family and domain databases

InterProiIPR027845. DUF4548.
[Graphical view]
PfamiPF15081. DUF4548. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Rhodes S.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-137.
    Tissue: Brain.

Entry informationi

Entry nameiCA105_HUMAN
AccessioniPrimary (citable) accession number: O95561
Secondary accession number(s): Q8IY02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 1, 1999
Last modified: June 24, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.