ID   GTR10_HUMAN             Reviewed;         541 AA.
AC   O95528; A8K4J6; Q3MIX5; Q9H4I6;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 2.
DT   27-MAR-2024, entry version 187.
DE   RecName: Full=Solute carrier family 2, facilitated glucose transporter member 10 {ECO:0000305};
DE   AltName: Full=Glucose transporter type 10 {ECO:0000303|PubMed:11247674};
DE            Short=GLUT-10 {ECO:0000303|PubMed:11247674};
GN   Name=SLC2A10 {ECO:0000303|PubMed:11247674,
GN   ECO:0000312|HGNC:HGNC:13444};
GN   Synonyms=GLUT10 {ECO:0000303|PubMed:11247674};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=11247674; DOI=10.1006/geno.2000.6457;
RA   McVie-Wylie A.J., Lamson D.R., Chen Y.T.;
RT   "Molecular cloning of a novel member of the GLUT family of transporters,
RT   SLC2A10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for
RT   NIDDM susceptibility.";
RL   Genomics 72:113-117(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TRANSPORTER ACTIVITY,
RP   BIOPHYSICOCHEMICAL PROPERTIES, AND TISSUE SPECIFICITY.
RX   PubMed=11592815; DOI=10.1006/mgme.2001.3212;
RA   Dawson P.A., Mychaleckyj J.C., Fossey S.C., Mihic S.J., Craddock A.L.,
RA   Bowden D.W.;
RT   "Sequence and functional analysis of GLUT10: a glucose transporter in the
RT   Type 2 diabetes-linked region of chromosome 20q12-13.1.";
RL   Mol. Genet. Metab. 74:186-199(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Stavrides G.S., Hashim Y., Huckle E.J., Deloukas P.;
RL   Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   ASSOCIATION OF VARIANT THR-206 WITH LOWER SERUM INSULIN LEVEL.
RX   PubMed=12941788; DOI=10.2337/diabetes.52.9.2445;
RA   Andersen G., Rose C.S., Hamid Y.H., Drivsholm T., Borch-Johnsen K.,
RA   Hansen T., Pedersen O.;
RT   "Genetic variation of the GLUT10 glucose transporter (SLC2A10) and
RT   relationships to type 2 diabetes and intermediary traits.";
RL   Diabetes 52:2445-2448(2003).
RN   [9]
RP   VARIANT ATORS ARG-81, SUBCELLULAR LOCATION, AND FUNCTION.
RX   PubMed=16550171; DOI=10.1038/ng1764;
RA   Coucke P.J., Willaert A., Wessels M.W., Callewaert B., Zoppi N.,
RA   De Backer J., Fox J.E., Mancini G.M.S., Kambouris M., Gardella R.,
RA   Facchetti F., Willems P.J., Forsyth R., Dietz H.C., Barlati S., Colombi M.,
RA   Loeys B., De Paepe A.;
RT   "Mutations in the facilitative glucose transporter GLUT10 alter
RT   angiogenesis and cause arterial tortuosity syndrome.";
RL   Nat. Genet. 38:452-457(2006).
RN   [10]
RP   VARIANTS ATORS TRP-132; VAL-142; GLN-231; GLU-246; TRP-426; LYS-437 AND
RP   GLU-445.
RX   PubMed=17935213; DOI=10.1002/humu.20623;
RA   Callewaert B.L., Willaert A., Kerstjens-Frederikse W.S., De Backer J.,
RA   Devriendt K., Albrecht B., Ramos-Arroyo M.A., Doco-Fenzy M.,
RA   Hennekam R.C.M., Pyeritz R.E., Krogmann O.N., Gillessen-kaesbach G.,
RA   Wakeling E.L., Nik-zainal S., Francannet C., Mauran P., Booth C.,
RA   Barrow M., Dekens R., Loeys B.L., Coucke P.J., De Paepe A.M.;
RT   "Arterial tortuosity syndrome: clinical and molecular findings in 12 newly
RT   identified families.";
RL   Hum. Mutat. 29:150-158(2008).
CC   -!- FUNCTION: Facilitative glucose transporter required for the development
CC       of the cardiovascular system. {ECO:0000269|PubMed:11592815,
CC       ECO:0000269|PubMed:16550171}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376,
CC         ChEBI:CHEBI:4167; Evidence={ECO:0000269|PubMed:11592815};
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       Kinetic parameters:
CC         KM=0.28 mM for 2-deoxy-D-glucose {ECO:0000269|PubMed:11592815};
CC   -!- SUBCELLULAR LOCATION: Endomembrane system
CC       {ECO:0000269|PubMed:16550171}; Multi-pass membrane protein
CC       {ECO:0000255}. Cytoplasm, perinuclear region
CC       {ECO:0000269|PubMed:16550171}.
CC   -!- TISSUE SPECIFICITY: Widely expressed; highest levels in liver and
CC       pancreas. {ECO:0000269|PubMed:11592815}.
CC   -!- DISEASE: Arterial tortuosity syndrome (ATORS) [MIM:208050]: An
CC       autosomal recessive disorder characterized by tortuosity and elongation
CC       of major arteries, often resulting in death at young age. Other typical
CC       features include aneurysms of large arteries and stenosis of the
CC       pulmonary artery, in association with facial features and several
CC       connective tissue manifestations such as soft skin and joint laxity.
CC       Histopathological findings include fragmentation of elastic fibers in
CC       the tunica media of large arteries. {ECO:0000269|PubMed:16550171,
CC       ECO:0000269|PubMed:17935213}. Note=The disease is caused by variants
CC       affecting the gene represented in this entry.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC       transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF321240; AAK26294.1; -; mRNA.
DR   EMBL; AF248053; AAK31911.1; -; mRNA.
DR   EMBL; AL137188; CAB69822.2; -; mRNA.
DR   EMBL; AK290961; BAF83650.1; -; mRNA.
DR   EMBL; AL031055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471077; EAW75724.1; -; Genomic_DNA.
DR   EMBL; BC101657; AAI01658.1; -; mRNA.
DR   EMBL; BC113423; AAI13424.1; -; mRNA.
DR   CCDS; CCDS13402.1; -.
DR   RefSeq; NP_110404.1; NM_030777.3.
DR   AlphaFoldDB; O95528; -.
DR   SMR; O95528; -.
DR   BioGRID; 123350; 8.
DR   STRING; 9606.ENSP00000352216; -.
DR   DrugBank; DB01914; D-glucose.
DR   DrugBank; DB09341; Dextrose, unspecified form.
DR   DrugBank; DB09502; Fludeoxyglucose (18F).
DR   TCDB; 2.A.1.1.59; the major facilitator superfamily (mfs).
DR   GlyCosmos; O95528; 1 site, No reported glycans.
DR   GlyGen; O95528; 1 site.
DR   iPTMnet; O95528; -.
DR   PhosphoSitePlus; O95528; -.
DR   SwissPalm; O95528; -.
DR   BioMuta; SLC2A10; -.
DR   jPOST; O95528; -.
DR   MassIVE; O95528; -.
DR   MaxQB; O95528; -.
DR   PaxDb; 9606-ENSP00000352216; -.
DR   PeptideAtlas; O95528; -.
DR   ProteomicsDB; 50935; -.
DR   Antibodypedia; 13253; 169 antibodies from 28 providers.
DR   DNASU; 81031; -.
DR   Ensembl; ENST00000359271.4; ENSP00000352216.2; ENSG00000197496.6.
DR   GeneID; 81031; -.
DR   KEGG; hsa:81031; -.
DR   MANE-Select; ENST00000359271.4; ENSP00000352216.2; NM_030777.4; NP_110404.1.
DR   UCSC; uc002xsl.4; human.
DR   AGR; HGNC:13444; -.
DR   CTD; 81031; -.
DR   DisGeNET; 81031; -.
DR   GeneCards; SLC2A10; -.
DR   GeneReviews; SLC2A10; -.
DR   HGNC; HGNC:13444; SLC2A10.
DR   HPA; ENSG00000197496; Low tissue specificity.
DR   MalaCards; SLC2A10; -.
DR   MIM; 208050; phenotype.
DR   MIM; 606145; gene.
DR   neXtProt; NX_O95528; -.
DR   OpenTargets; ENSG00000197496; -.
DR   Orphanet; 3342; Arterial tortuosity syndrome.
DR   PharmGKB; PA37769; -.
DR   VEuPathDB; HostDB:ENSG00000197496; -.
DR   eggNOG; KOG0254; Eukaryota.
DR   GeneTree; ENSGT00940000159430; -.
DR   HOGENOM; CLU_001265_30_5_1; -.
DR   InParanoid; O95528; -.
DR   OMA; GCYRIPV; -.
DR   OrthoDB; 2013244at2759; -.
DR   PhylomeDB; O95528; -.
DR   TreeFam; TF332408; -.
DR   PathwayCommons; O95528; -.
DR   Reactome; R-HSA-189200; Cellular hexose transport.
DR   Reactome; R-HSA-5619068; Defective SLC2A10 causes arterial tortuosity syndrome (ATS).
DR   BioGRID-ORCS; 81031; 12 hits in 1143 CRISPR screens.
DR   ChiTaRS; SLC2A10; human.
DR   GeneWiki; SLC2A10; -.
DR   GenomeRNAi; 81031; -.
DR   Pharos; O95528; Tbio.
DR   PRO; PR:O95528; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; O95528; Protein.
DR   Bgee; ENSG00000197496; Expressed in tibia and 159 other cell types or tissues.
DR   ExpressionAtlas; O95528; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:ARUK-UCL.
DR   GO; GO:0005886; C:plasma membrane; IDA:ARUK-UCL.
DR   GO; GO:0005351; F:carbohydrate:proton symporter activity; NAS:UniProtKB.
DR   GO; GO:0055056; F:D-glucose transmembrane transporter activity; IDA:ARUK-UCL.
DR   GO; GO:0033300; F:dehydroascorbic acid transmembrane transporter activity; IDA:ARUK-UCL.
DR   GO; GO:0015293; F:symporter activity; IBA:GO_Central.
DR   GO; GO:0060840; P:artery development; IMP:ARUK-UCL.
DR   GO; GO:0045454; P:cell redox homeostasis; IMP:ARUK-UCL.
DR   GO; GO:0072359; P:circulatory system development; IBA:GO_Central.
DR   GO; GO:0070837; P:dehydroascorbic acid transport; IDA:ARUK-UCL.
DR   GO; GO:0072498; P:embryonic skeletal joint development; IMP:ARUK-UCL.
DR   GO; GO:0015757; P:galactose transmembrane transport; TAS:ARUK-UCL.
DR   GO; GO:0098708; P:glucose import across plasma membrane; IDA:ARUK-UCL.
DR   GO; GO:1904659; P:glucose transmembrane transport; IBA:GO_Central.
DR   GO; GO:0008645; P:hexose transmembrane transport; TAS:Reactome.
DR   GO; GO:0032683; P:negative regulation of connective tissue growth factor production; IMP:ARUK-UCL.
DR   GO; GO:0010629; P:negative regulation of gene expression; IMP:ARUK-UCL.
DR   GO; GO:2001045; P:negative regulation of integrin-mediated signaling pathway; IMP:ARUK-UCL.
DR   GO; GO:1902729; P:negative regulation of proteoglycan biosynthetic process; IMP:ARUK-UCL.
DR   GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IMP:ARUK-UCL.
DR   GO; GO:0010628; P:positive regulation of gene expression; IMP:ARUK-UCL.
DR   GO; GO:1902730; P:positive regulation of proteoglycan biosynthetic process; IMP:ARUK-UCL.
DR   GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IMP:ARUK-UCL.
DR   GO; GO:1903053; P:regulation of extracellular matrix organization; IMP:ARUK-UCL.
DR   GO; GO:0043588; P:skin development; IMP:ARUK-UCL.
DR   GO; GO:0150104; P:transport across blood-brain barrier; NAS:ARUK-UCL.
DR   CDD; cd17436; MFS_GLUT10_Class3; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 3.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR003663; Sugar/inositol_transpt.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   PANTHER; PTHR48023; D-XYLOSE-PROTON SYMPORTER-LIKE 2; 1.
DR   PANTHER; PTHR48023:SF7; SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 10; 1.
DR   Pfam; PF00083; Sugar_tr; 3.
DR   PRINTS; PR00171; SUGRTRNSPORT.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 2.
DR   Genevisible; O95528; HS.
PE   1: Evidence at protein level;
KW   Cytoplasm; Disease variant; Glycoprotein; Membrane; Reference proteome;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..541
FT                   /note="Solute carrier family 2, facilitated glucose
FT                   transporter member 10"
FT                   /id="PRO_0000050379"
FT   TOPO_DOM        1..15
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        16..36
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        37..48
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        70..77
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..106
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        128..134
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        156..166
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        188..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        255..269
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        291..298
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..319
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        320..414
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        415..435
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        436..445
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        446..466
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        467..476
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        477..497
FT                   /note="Helical; Name=12"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        498..541
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          340..388
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..358
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        365..379
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         242..243
FT                   /ligand="D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:4167"
FT                   /evidence="ECO:0000250|UniProtKB:P11169"
FT   BINDING         432
FT                   /ligand="D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:4167"
FT                   /evidence="ECO:0000250|UniProtKB:P11169"
FT   CARBOHYD        334
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         81
FT                   /note="S -> R (in ATORS; dbSNP:rs80358230)"
FT                   /evidence="ECO:0000269|PubMed:16550171"
FT                   /id="VAR_029535"
FT   VARIANT         106
FT                   /note="A -> S (in dbSNP:rs6094438)"
FT                   /id="VAR_029536"
FT   VARIANT         132
FT                   /note="R -> W (in ATORS; dbSNP:rs121908173)"
FT                   /evidence="ECO:0000269|PubMed:17935213"
FT                   /id="VAR_042417"
FT   VARIANT         142
FT                   /note="G -> V (in ATORS; dbSNP:rs864309480)"
FT                   /evidence="ECO:0000269|PubMed:17935213"
FT                   /id="VAR_042418"
FT   VARIANT         206
FT                   /note="A -> T (associated with lower insulin level;
FT                   dbSNP:rs2235491)"
FT                   /evidence="ECO:0000269|PubMed:12941788"
FT                   /id="VAR_029335"
FT   VARIANT         225
FT                   /note="R -> H (in dbSNP:rs34295241)"
FT                   /id="VAR_042419"
FT   VARIANT         231
FT                   /note="R -> Q (in ATORS; dbSNP:rs771028960)"
FT                   /evidence="ECO:0000269|PubMed:17935213"
FT                   /id="VAR_042420"
FT   VARIANT         246
FT                   /note="G -> E (in ATORS; dbSNP:rs564317065)"
FT                   /evidence="ECO:0000269|PubMed:17935213"
FT                   /id="VAR_042421"
FT   VARIANT         426
FT                   /note="G -> W (in ATORS; dbSNP:rs121908172)"
FT                   /evidence="ECO:0000269|PubMed:17935213"
FT                   /id="VAR_042422"
FT   VARIANT         437
FT                   /note="E -> K (in ATORS; dbSNP:rs763220502)"
FT                   /evidence="ECO:0000269|PubMed:17935213"
FT                   /id="VAR_042423"
FT   VARIANT         445
FT                   /note="G -> E (in ATORS; dbSNP:rs753723351)"
FT                   /evidence="ECO:0000269|PubMed:17935213"
FT                   /id="VAR_042424"
FT   VARIANT         518
FT                   /note="T -> A (in dbSNP:rs6018008)"
FT                   /id="VAR_024652"
FT   VARIANT         537
FT                   /note="I -> V (in dbSNP:rs7348121)"
FT                   /id="VAR_029537"
SQ   SEQUENCE   541 AA;  56911 MW;  6D644525FA136908 CRC64;
     MGHSPPVLPL CASVSLLGGL TFGYELAVIS GALLPLQLDF GLSCLEQEFL VGSLLLGALL
     ASLVGGFLID CYGRKQAILG SNLVLLAGSL TLGLAGSLAW LVLGRAVVGF AISLSSMACC
     IYVSELVGPR QRGVLVSLYE AGITVGILLS YALNYALAGT PWGWRHMFGW ATAPAVLQSL
     SLLFLPAGTD ETATHKDLIP LQGGEAPKLG PGRPRYSFLD LFRARDNMRG RTTVGLGLVL
     FQQLTGQPNV LCYASTIFSS VGFHGGSSAV LASVGLGAVK VAATLTAMGL VDRAGRRALL
     LAGCALMALS VSGIGLVSFA VPMDSGPSCL AVPNATGQTG LPGDSGLLQD SSLPPIPRTN
     EDQREPILST AKKTKPHPRS GDPSAPPRLA LSSALPGPPL PARGHALLRW TALLCLMVFV
     SAFSFGFGPV TWLVLSEIYP VEIRGRAFAF CNSFNWAANL FISLSFLDLI GTIGLSWTFL
     LYGLTAVLGL GFIYLFVPET KGQSLAEIDQ QFQKRRFTLS FGHRQNSTGI PYSRIEISAA
     S
//