Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 2, facilitated glucose transporter member 10

Gene

SLC2A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter.

Kineticsi

  1. KM=0.28 mM for 2-deoxy-D-glucose

    GO - Molecular functioni

    • glucose transmembrane transporter activity Source: GO_Central
    • sugar:proton symporter activity Source: UniProtKB

    GO - Biological processi

    Complete GO annotation...

    Keywords - Biological processi

    Sugar transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_19343. Facilitative Na+-independent glucose transporters.

    Protein family/group databases

    TCDBi2.A.1.1.59. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 10
    Alternative name(s):
    Glucose transporter type 10
    Short name:
    GLUT-10
    Gene namesi
    Name:SLC2A10
    Synonyms:GLUT10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640 Componenti: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:13444. SLC2A10.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
    BLAST
    Transmembranei16 – 3621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Topological domaini37 – 4812ExtracellularSequence AnalysisAdd
    BLAST
    Transmembranei49 – 6921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Topological domaini70 – 778CytoplasmicSequence Analysis
    Transmembranei78 – 9821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Topological domaini99 – 1068ExtracellularSequence Analysis
    Transmembranei107 – 12721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Topological domaini128 – 1347CytoplasmicSequence Analysis
    Transmembranei135 – 15521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Topological domaini156 – 16611ExtracellularSequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Topological domaini188 – 23346CytoplasmicSequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421Helical; Name=7Sequence AnalysisAdd
    BLAST
    Topological domaini255 – 26915ExtracellularSequence AnalysisAdd
    BLAST
    Transmembranei270 – 29021Helical; Name=8Sequence AnalysisAdd
    BLAST
    Topological domaini291 – 2988CytoplasmicSequence Analysis
    Transmembranei299 – 31921Helical; Name=9Sequence AnalysisAdd
    BLAST
    Topological domaini320 – 41495ExtracellularSequence AnalysisAdd
    BLAST
    Transmembranei415 – 43521Helical; Name=10Sequence AnalysisAdd
    BLAST
    Topological domaini436 – 44510CytoplasmicSequence Analysis
    Transmembranei446 – 46621Helical; Name=11Sequence AnalysisAdd
    BLAST
    Topological domaini467 – 47610ExtracellularSequence Analysis
    Transmembranei477 – 49721Helical; Name=12Sequence AnalysisAdd
    BLAST
    Topological domaini498 – 54144CytoplasmicSequence AnalysisAdd
    BLAST

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Arterial tortuosity syndrome (ATS)2 Publications

    The disease is caused by mutations affecting the gene represented in this entry.

    Disease descriptionAn autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries.

    See also OMIM:208050
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti81 – 811S → R in ATS. 1 Publication
    VAR_029535
    Natural varianti132 – 1321R → W in ATS. 1 Publication
    VAR_042417
    Natural varianti142 – 1421G → V in ATS. 1 Publication
    VAR_042418
    Natural varianti231 – 2311R → Q in ATS. 1 Publication
    VAR_042420
    Natural varianti246 – 2461G → E in ATS. 1 Publication
    VAR_042421
    Natural varianti426 – 4261G → W in ATS. 1 Publication
    VAR_042422
    Natural varianti437 – 4371E → K in ATS. 1 Publication
    VAR_042423
    Natural varianti445 – 4451G → E in ATS.
    VAR_042424

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi208050. phenotype.
    Orphaneti3342. Arterial tortuosity syndrome.
    PharmGKBiPA37769.

    Polymorphism and mutation databases

    BioMutaiSLC2A10.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 541541Solute carrier family 2, facilitated glucose transporter member 10PRO_0000050379Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO95528.
    PaxDbiO95528.
    PRIDEiO95528.

    PTM databases

    PhosphoSiteiO95528.

    Expressioni

    Tissue specificityi

    Widely expressed; highest levels in liver and pancreas.1 Publication

    Gene expression databases

    BgeeiO95528.
    CleanExiHS_SLC2A10.
    ExpressionAtlasiO95528. baseline and differential.
    GenevisibleiO95528. HS.

    Organism-specific databases

    HPAiHPA041015.
    HPA055673.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000352216.

    Structurei

    3D structure databases

    ProteinModelPortaliO95528.
    SMRiO95528. Positions 27-320, 412-509.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00590000083062.
    HOGENOMiHOG000202868.
    HOVERGENiHBG051858.
    InParanoidiO95528.
    KOiK08147.
    OMAiPIPRTNE.
    OrthoDBiEOG75B852.
    PhylomeDBiO95528.
    TreeFamiTF332408.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 2 hits.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95528-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MGHSPPVLPL CASVSLLGGL TFGYELAVIS GALLPLQLDF GLSCLEQEFL
    60 70 80 90 100
    VGSLLLGALL ASLVGGFLID CYGRKQAILG SNLVLLAGSL TLGLAGSLAW
    110 120 130 140 150
    LVLGRAVVGF AISLSSMACC IYVSELVGPR QRGVLVSLYE AGITVGILLS
    160 170 180 190 200
    YALNYALAGT PWGWRHMFGW ATAPAVLQSL SLLFLPAGTD ETATHKDLIP
    210 220 230 240 250
    LQGGEAPKLG PGRPRYSFLD LFRARDNMRG RTTVGLGLVL FQQLTGQPNV
    260 270 280 290 300
    LCYASTIFSS VGFHGGSSAV LASVGLGAVK VAATLTAMGL VDRAGRRALL
    310 320 330 340 350
    LAGCALMALS VSGIGLVSFA VPMDSGPSCL AVPNATGQTG LPGDSGLLQD
    360 370 380 390 400
    SSLPPIPRTN EDQREPILST AKKTKPHPRS GDPSAPPRLA LSSALPGPPL
    410 420 430 440 450
    PARGHALLRW TALLCLMVFV SAFSFGFGPV TWLVLSEIYP VEIRGRAFAF
    460 470 480 490 500
    CNSFNWAANL FISLSFLDLI GTIGLSWTFL LYGLTAVLGL GFIYLFVPET
    510 520 530 540
    KGQSLAEIDQ QFQKRRFTLS FGHRQNSTGI PYSRIEISAA S
    Length:541
    Mass (Da):56,911
    Last modified:June 1, 2001 - v2
    Checksum:i6D644525FA136908
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti81 – 811S → R in ATS. 1 Publication
    VAR_029535
    Natural varianti106 – 1061A → S.
    Corresponds to variant rs6094438 [ dbSNP | Ensembl ].
    VAR_029536
    Natural varianti132 – 1321R → W in ATS. 1 Publication
    VAR_042417
    Natural varianti142 – 1421G → V in ATS. 1 Publication
    VAR_042418
    Natural varianti206 – 2061A → T Associated with lower insulin level.
    Corresponds to variant rs2235491 [ dbSNP | Ensembl ].
    VAR_029335
    Natural varianti225 – 2251R → H.
    Corresponds to variant rs34295241 [ dbSNP | Ensembl ].
    VAR_042419
    Natural varianti231 – 2311R → Q in ATS. 1 Publication
    VAR_042420
    Natural varianti246 – 2461G → E in ATS. 1 Publication
    VAR_042421
    Natural varianti426 – 4261G → W in ATS. 1 Publication
    VAR_042422
    Natural varianti437 – 4371E → K in ATS. 1 Publication
    VAR_042423
    Natural varianti445 – 4451G → E in ATS.
    VAR_042424
    Natural varianti518 – 5181T → A.
    Corresponds to variant rs6018008 [ dbSNP | Ensembl ].
    VAR_024652
    Natural varianti537 – 5371I → V.
    Corresponds to variant rs7348121 [ dbSNP | Ensembl ].
    VAR_029537

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF321240 mRNA. Translation: AAK26294.1.
    AF248053 mRNA. Translation: AAK31911.1.
    AL137188 mRNA. Translation: CAB69822.2.
    AK290961 mRNA. Translation: BAF83650.1.
    AL031055 Genomic DNA. Translation: CAA19926.2.
    CH471077 Genomic DNA. Translation: EAW75724.1.
    BC101657 mRNA. Translation: AAI01658.1.
    BC113423 mRNA. Translation: AAI13424.1.
    CCDSiCCDS13402.1.
    RefSeqiNP_110404.1. NM_030777.3.
    UniGeneiHs.305971.

    Genome annotation databases

    EnsembliENST00000359271; ENSP00000352216; ENSG00000197496.
    GeneIDi81031.
    KEGGihsa:81031.
    UCSCiuc002xsl.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF321240 mRNA. Translation: AAK26294.1.
    AF248053 mRNA. Translation: AAK31911.1.
    AL137188 mRNA. Translation: CAB69822.2.
    AK290961 mRNA. Translation: BAF83650.1.
    AL031055 Genomic DNA. Translation: CAA19926.2.
    CH471077 Genomic DNA. Translation: EAW75724.1.
    BC101657 mRNA. Translation: AAI01658.1.
    BC113423 mRNA. Translation: AAI13424.1.
    CCDSiCCDS13402.1.
    RefSeqiNP_110404.1. NM_030777.3.
    UniGeneiHs.305971.

    3D structure databases

    ProteinModelPortaliO95528.
    SMRiO95528. Positions 27-320, 412-509.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi9606.ENSP00000352216.

    Protein family/group databases

    TCDBi2.A.1.1.59. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSiteiO95528.

    Polymorphism and mutation databases

    BioMutaiSLC2A10.

    Proteomic databases

    MaxQBiO95528.
    PaxDbiO95528.
    PRIDEiO95528.

    Protocols and materials databases

    DNASUi81031.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000359271; ENSP00000352216; ENSG00000197496.
    GeneIDi81031.
    KEGGihsa:81031.
    UCSCiuc002xsl.3. human.

    Organism-specific databases

    CTDi81031.
    GeneCardsiGC20P045338.
    HGNCiHGNC:13444. SLC2A10.
    HPAiHPA041015.
    HPA055673.
    MIMi208050. phenotype.
    606145. gene.
    neXtProtiNX_O95528.
    Orphaneti3342. Arterial tortuosity syndrome.
    PharmGKBiPA37769.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00590000083062.
    HOGENOMiHOG000202868.
    HOVERGENiHBG051858.
    InParanoidiO95528.
    KOiK08147.
    OMAiPIPRTNE.
    OrthoDBiEOG75B852.
    PhylomeDBiO95528.
    TreeFamiTF332408.

    Enzyme and pathway databases

    ReactomeiREACT_19343. Facilitative Na+-independent glucose transporters.

    Miscellaneous databases

    ChiTaRSiSLC2A10. human.
    GeneWikiiSLC2A10.
    GenomeRNAii81031.
    NextBioi71362.
    PROiO95528.
    SOURCEiSearch...

    Gene expression databases

    BgeeiO95528.
    CleanExiHS_SLC2A10.
    ExpressionAtlasiO95528. baseline and differential.
    GenevisibleiO95528. HS.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 2 hits.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 2 hits.
    [Graphical view]
    ProtoNetiSearch...

    Publicationsi

    « Hide 'large scale' publications
    1. "Molecular cloning of a novel member of the GLUT family of transporters, SLC2A10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility."
      McVie-Wylie A.J., Lamson D.R., Chen Y.T.
      Genomics 72:113-117(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1."
      Dawson P.A., Mychaleckyj J.C., Fossey S.C., Mihic S.J., Craddock A.L., Bowden D.W.
      Mol. Genet. Metab. 74:186-199(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, CHARACTERIZATION.
    3. Stavrides G.S., Hashim Y., Huckle E.J., Deloukas P.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    8. "Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits."
      Andersen G., Rose C.S., Hamid Y.H., Drivsholm T., Borch-Johnsen K., Hansen T., Pedersen O.
      Diabetes 52:2445-2448(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: ASSOCIATION OF VARIANT THR-206 WITH LOWER SERUM INSULIN LEVEL.
    9. Cited for: VARIANT ATS ARG-81, SUBCELLULAR LOCATION.
    10. Cited for: VARIANTS ATS TRP-132; VAL-142; GLN-231; GLU-246; TRP-426 AND LYS-437.

    Entry informationi

    Entry nameiGTR10_HUMAN
    AccessioniPrimary (citable) accession number: O95528
    Secondary accession number(s): A8K4J6, Q3MIX5, Q9H4I6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: June 1, 2001
    Last modified: July 22, 2015
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.