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Protein

Solute carrier family 2, facilitated glucose transporter member 10

Gene

SLC2A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter.

Kineticsi

  1. KM=0.28 mM for 2-deoxy-D-glucose

    GO - Molecular functioni

    GO - Biological processi

    • glucose import Source: GO_Central
    • glucose transport Source: UniProtKB
    Complete GO annotation...

    Keywords - Biological processi

    Sugar transport, Transport

    Enzyme and pathway databases

    ReactomeiR-HSA-428790. Facilitative Na+-independent glucose transporters.

    Protein family/group databases

    TCDBi2.A.1.1.59. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 10
    Alternative name(s):
    Glucose transporter type 10
    Short name:
    GLUT-10
    Gene namesi
    Name:SLC2A10
    Synonyms:GLUT10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:13444. SLC2A10.

    Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
    Transmembranei16 – 36Helical; Name=1Sequence analysisAdd BLAST21
    Topological domaini37 – 48ExtracellularSequence analysisAdd BLAST12
    Transmembranei49 – 69Helical; Name=2Sequence analysisAdd BLAST21
    Topological domaini70 – 77CytoplasmicSequence analysis8
    Transmembranei78 – 98Helical; Name=3Sequence analysisAdd BLAST21
    Topological domaini99 – 106ExtracellularSequence analysis8
    Transmembranei107 – 127Helical; Name=4Sequence analysisAdd BLAST21
    Topological domaini128 – 134CytoplasmicSequence analysis7
    Transmembranei135 – 155Helical; Name=5Sequence analysisAdd BLAST21
    Topological domaini156 – 166ExtracellularSequence analysisAdd BLAST11
    Transmembranei167 – 187Helical; Name=6Sequence analysisAdd BLAST21
    Topological domaini188 – 233CytoplasmicSequence analysisAdd BLAST46
    Transmembranei234 – 254Helical; Name=7Sequence analysisAdd BLAST21
    Topological domaini255 – 269ExtracellularSequence analysisAdd BLAST15
    Transmembranei270 – 290Helical; Name=8Sequence analysisAdd BLAST21
    Topological domaini291 – 298CytoplasmicSequence analysis8
    Transmembranei299 – 319Helical; Name=9Sequence analysisAdd BLAST21
    Topological domaini320 – 414ExtracellularSequence analysisAdd BLAST95
    Transmembranei415 – 435Helical; Name=10Sequence analysisAdd BLAST21
    Topological domaini436 – 445CytoplasmicSequence analysis10
    Transmembranei446 – 466Helical; Name=11Sequence analysisAdd BLAST21
    Topological domaini467 – 476ExtracellularSequence analysis10
    Transmembranei477 – 497Helical; Name=12Sequence analysisAdd BLAST21
    Topological domaini498 – 541CytoplasmicSequence analysisAdd BLAST44

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Arterial tortuosity syndrome (ATS)2 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionAn autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries.
    See also OMIM:208050
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_02953581S → R in ATS. 1 PublicationCorresponds to variant rs80358230dbSNPEnsembl.1
    Natural variantiVAR_042417132R → W in ATS. 1 PublicationCorresponds to variant rs121908173dbSNPEnsembl.1
    Natural variantiVAR_042418142G → V in ATS. 1 Publication1
    Natural variantiVAR_042420231R → Q in ATS. 1 PublicationCorresponds to variant rs771028960dbSNPEnsembl.1
    Natural variantiVAR_042421246G → E in ATS. 1 PublicationCorresponds to variant rs564317065dbSNPEnsembl.1
    Natural variantiVAR_042422426G → W in ATS. 1 PublicationCorresponds to variant rs121908172dbSNPEnsembl.1
    Natural variantiVAR_042423437E → K in ATS. 1 PublicationCorresponds to variant rs763220502dbSNPEnsembl.1
    Natural variantiVAR_042424445G → E in ATS. Corresponds to variant rs753723351dbSNPEnsembl.1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNETi81031.
    MalaCardsiSLC2A10.
    MIMi208050. phenotype.
    OpenTargetsiENSG00000197496.
    Orphaneti3342. Arterial tortuosity syndrome.
    PharmGKBiPA37769.

    Polymorphism and mutation databases

    BioMutaiSLC2A10.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000503791 – 541Solute carrier family 2, facilitated glucose transporter member 10Add BLAST541

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Glycosylationi334N-linked (GlcNAc...)Sequence analysis1

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    EPDiO95528.
    MaxQBiO95528.
    PaxDbiO95528.
    PeptideAtlasiO95528.
    PRIDEiO95528.

    PTM databases

    iPTMnetiO95528.
    PhosphoSitePlusiO95528.

    Expressioni

    Tissue specificityi

    Widely expressed; highest levels in liver and pancreas.1 Publication

    Gene expression databases

    BgeeiENSG00000197496.
    CleanExiHS_SLC2A10.
    ExpressionAtlasiO95528. baseline and differential.
    GenevisibleiO95528. HS.

    Organism-specific databases

    HPAiHPA041015.
    HPA055673.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000352216.

    Structurei

    3D structure databases

    ProteinModelPortaliO95528.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0254. Eukaryota.
    ENOG410XNQK. LUCA.
    GeneTreeiENSGT00850000132274.
    HOGENOMiHOG000202868.
    HOVERGENiHBG051858.
    InParanoidiO95528.
    KOiK08147.
    OMAiPIPRTNE.
    OrthoDBiEOG091G085H.
    PhylomeDBiO95528.
    TreeFamiTF332408.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiIPR020846. MFS_dom.
    IPR005828. MFS_sugar_transport-like.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 2 hits.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95528-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MGHSPPVLPL CASVSLLGGL TFGYELAVIS GALLPLQLDF GLSCLEQEFL
    60 70 80 90 100
    VGSLLLGALL ASLVGGFLID CYGRKQAILG SNLVLLAGSL TLGLAGSLAW
    110 120 130 140 150
    LVLGRAVVGF AISLSSMACC IYVSELVGPR QRGVLVSLYE AGITVGILLS
    160 170 180 190 200
    YALNYALAGT PWGWRHMFGW ATAPAVLQSL SLLFLPAGTD ETATHKDLIP
    210 220 230 240 250
    LQGGEAPKLG PGRPRYSFLD LFRARDNMRG RTTVGLGLVL FQQLTGQPNV
    260 270 280 290 300
    LCYASTIFSS VGFHGGSSAV LASVGLGAVK VAATLTAMGL VDRAGRRALL
    310 320 330 340 350
    LAGCALMALS VSGIGLVSFA VPMDSGPSCL AVPNATGQTG LPGDSGLLQD
    360 370 380 390 400
    SSLPPIPRTN EDQREPILST AKKTKPHPRS GDPSAPPRLA LSSALPGPPL
    410 420 430 440 450
    PARGHALLRW TALLCLMVFV SAFSFGFGPV TWLVLSEIYP VEIRGRAFAF
    460 470 480 490 500
    CNSFNWAANL FISLSFLDLI GTIGLSWTFL LYGLTAVLGL GFIYLFVPET
    510 520 530 540
    KGQSLAEIDQ QFQKRRFTLS FGHRQNSTGI PYSRIEISAA S
    Length:541
    Mass (Da):56,911
    Last modified:June 1, 2001 - v2
    Checksum:i6D644525FA136908
    GO

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_02953581S → R in ATS. 1 PublicationCorresponds to variant rs80358230dbSNPEnsembl.1
    Natural variantiVAR_029536106A → S.Corresponds to variant rs6094438dbSNPEnsembl.1
    Natural variantiVAR_042417132R → W in ATS. 1 PublicationCorresponds to variant rs121908173dbSNPEnsembl.1
    Natural variantiVAR_042418142G → V in ATS. 1 Publication1
    Natural variantiVAR_029335206A → T Associated with lower insulin level. Corresponds to variant rs2235491dbSNPEnsembl.1
    Natural variantiVAR_042419225R → H.Corresponds to variant rs34295241dbSNPEnsembl.1
    Natural variantiVAR_042420231R → Q in ATS. 1 PublicationCorresponds to variant rs771028960dbSNPEnsembl.1
    Natural variantiVAR_042421246G → E in ATS. 1 PublicationCorresponds to variant rs564317065dbSNPEnsembl.1
    Natural variantiVAR_042422426G → W in ATS. 1 PublicationCorresponds to variant rs121908172dbSNPEnsembl.1
    Natural variantiVAR_042423437E → K in ATS. 1 PublicationCorresponds to variant rs763220502dbSNPEnsembl.1
    Natural variantiVAR_042424445G → E in ATS. Corresponds to variant rs753723351dbSNPEnsembl.1
    Natural variantiVAR_024652518T → A.Corresponds to variant rs6018008dbSNPEnsembl.1
    Natural variantiVAR_029537537I → V.Corresponds to variant rs7348121dbSNPEnsembl.1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF321240 mRNA. Translation: AAK26294.1.
    AF248053 mRNA. Translation: AAK31911.1.
    AL137188 mRNA. Translation: CAB69822.2.
    AK290961 mRNA. Translation: BAF83650.1.
    AL031055 Genomic DNA. Translation: CAA19926.2.
    CH471077 Genomic DNA. Translation: EAW75724.1.
    BC101657 mRNA. Translation: AAI01658.1.
    BC113423 mRNA. Translation: AAI13424.1.
    CCDSiCCDS13402.1.
    RefSeqiNP_110404.1. NM_030777.3.
    UniGeneiHs.305971.

    Genome annotation databases

    EnsembliENST00000359271; ENSP00000352216; ENSG00000197496.
    GeneIDi81031.
    KEGGihsa:81031.
    UCSCiuc002xsl.4. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF321240 mRNA. Translation: AAK26294.1.
    AF248053 mRNA. Translation: AAK31911.1.
    AL137188 mRNA. Translation: CAB69822.2.
    AK290961 mRNA. Translation: BAF83650.1.
    AL031055 Genomic DNA. Translation: CAA19926.2.
    CH471077 Genomic DNA. Translation: EAW75724.1.
    BC101657 mRNA. Translation: AAI01658.1.
    BC113423 mRNA. Translation: AAI13424.1.
    CCDSiCCDS13402.1.
    RefSeqiNP_110404.1. NM_030777.3.
    UniGeneiHs.305971.

    3D structure databases

    ProteinModelPortaliO95528.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi9606.ENSP00000352216.

    Protein family/group databases

    TCDBi2.A.1.1.59. the major facilitator superfamily (mfs).

    PTM databases

    iPTMnetiO95528.
    PhosphoSitePlusiO95528.

    Polymorphism and mutation databases

    BioMutaiSLC2A10.

    Proteomic databases

    EPDiO95528.
    MaxQBiO95528.
    PaxDbiO95528.
    PeptideAtlasiO95528.
    PRIDEiO95528.

    Protocols and materials databases

    DNASUi81031.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000359271; ENSP00000352216; ENSG00000197496.
    GeneIDi81031.
    KEGGihsa:81031.
    UCSCiuc002xsl.4. human.

    Organism-specific databases

    CTDi81031.
    DisGeNETi81031.
    GeneCardsiSLC2A10.
    HGNCiHGNC:13444. SLC2A10.
    HPAiHPA041015.
    HPA055673.
    MalaCardsiSLC2A10.
    MIMi208050. phenotype.
    606145. gene.
    neXtProtiNX_O95528.
    OpenTargetsiENSG00000197496.
    Orphaneti3342. Arterial tortuosity syndrome.
    PharmGKBiPA37769.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG0254. Eukaryota.
    ENOG410XNQK. LUCA.
    GeneTreeiENSGT00850000132274.
    HOGENOMiHOG000202868.
    HOVERGENiHBG051858.
    InParanoidiO95528.
    KOiK08147.
    OMAiPIPRTNE.
    OrthoDBiEOG091G085H.
    PhylomeDBiO95528.
    TreeFamiTF332408.

    Enzyme and pathway databases

    ReactomeiR-HSA-428790. Facilitative Na+-independent glucose transporters.

    Miscellaneous databases

    ChiTaRSiSLC2A10. human.
    GeneWikiiSLC2A10.
    GenomeRNAii81031.
    PROiO95528.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000197496.
    CleanExiHS_SLC2A10.
    ExpressionAtlasiO95528. baseline and differential.
    GenevisibleiO95528. HS.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiIPR020846. MFS_dom.
    IPR005828. MFS_sugar_transport-like.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 2 hits.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 2 hits.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiGTR10_HUMAN
    AccessioniPrimary (citable) accession number: O95528
    Secondary accession number(s): A8K4J6, Q3MIX5, Q9H4I6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: June 1, 2001
    Last modified: November 30, 2016
    This is version 143 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.