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Protein

Solute carrier family 2, facilitated glucose transporter member 10

Gene

SLC2A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter.

Kineticsi

  1. KM=0.28 mM for 2-deoxy-D-glucose

GO - Molecular functioni

  1. sugar:proton symporter activity Source: UniProtKB

GO - Biological processi

  1. glucose transport Source: UniProtKB
  2. proton transport Source: GOC
  3. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiREACT_19343. Facilitative Na+-independent glucose transporters.

Protein family/group databases

TCDBi2.A.1.1.59. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 10
Alternative name(s):
Glucose transporter type 10
Short name:
GLUT-10
Gene namesi
Name:SLC2A10
Synonyms:GLUT10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:13444. SLC2A10.

Subcellular locationi

  1. Endomembrane system 1 Publication; Multi-pass membrane protein 1 Publication
  2. Cytoplasmperinuclear region 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei16 – 3621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini37 – 4812ExtracellularSequence AnalysisAdd
BLAST
Transmembranei49 – 6921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini70 – 778CytoplasmicSequence Analysis
Transmembranei78 – 9821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini99 – 1068ExtracellularSequence Analysis
Transmembranei107 – 12721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini128 – 1347CytoplasmicSequence Analysis
Transmembranei135 – 15521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini156 – 16611ExtracellularSequence AnalysisAdd
BLAST
Transmembranei167 – 18721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini188 – 23346CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei234 – 25421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini255 – 26915ExtracellularSequence AnalysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini291 – 2988CytoplasmicSequence Analysis
Transmembranei299 – 31921Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini320 – 41495ExtracellularSequence AnalysisAdd
BLAST
Transmembranei415 – 43521Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini436 – 44510CytoplasmicSequence Analysis
Transmembranei446 – 46621Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini467 – 47610ExtracellularSequence Analysis
Transmembranei477 – 49721Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini498 – 54144CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. endomembrane system Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB
  4. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Arterial tortuosity syndrome (ATS)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries.

See also OMIM:208050
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti81 – 811S → R in ATS. 1 Publication
VAR_029535
Natural varianti132 – 1321R → W in ATS. 1 Publication
VAR_042417
Natural varianti142 – 1421G → V in ATS. 1 Publication
VAR_042418
Natural varianti231 – 2311R → Q in ATS. 1 Publication
VAR_042420
Natural varianti246 – 2461G → E in ATS. 1 Publication
VAR_042421
Natural varianti426 – 4261G → W in ATS. 1 Publication
VAR_042422
Natural varianti437 – 4371E → K in ATS. 1 Publication
VAR_042423
Natural varianti445 – 4451G → E in ATS.
VAR_042424

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi208050. phenotype.
Orphaneti3342. Arterial tortuosity syndrome.
PharmGKBiPA37769.

Polymorphism and mutation databases

BioMutaiSLC2A10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541Solute carrier family 2, facilitated glucose transporter member 10PRO_0000050379Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO95528.
PaxDbiO95528.
PRIDEiO95528.

PTM databases

PhosphoSiteiO95528.

Expressioni

Tissue specificityi

Widely expressed; highest levels in liver and pancreas.1 Publication

Gene expression databases

BgeeiO95528.
CleanExiHS_SLC2A10.
ExpressionAtlasiO95528. baseline and differential.
GenevestigatoriO95528.

Organism-specific databases

HPAiHPA041015.
HPA055673.

Interactioni

Protein-protein interaction databases

BioGridi123350. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO95528.
SMRiO95528. Positions 27-320, 412-509.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00590000083062.
HOGENOMiHOG000202868.
HOVERGENiHBG051858.
InParanoidiO95528.
KOiK08147.
OMAiSCLEQEF.
OrthoDBiEOG75B852.
PhylomeDBiO95528.
TreeFamiTF332408.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95528-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHSPPVLPL CASVSLLGGL TFGYELAVIS GALLPLQLDF GLSCLEQEFL
60 70 80 90 100
VGSLLLGALL ASLVGGFLID CYGRKQAILG SNLVLLAGSL TLGLAGSLAW
110 120 130 140 150
LVLGRAVVGF AISLSSMACC IYVSELVGPR QRGVLVSLYE AGITVGILLS
160 170 180 190 200
YALNYALAGT PWGWRHMFGW ATAPAVLQSL SLLFLPAGTD ETATHKDLIP
210 220 230 240 250
LQGGEAPKLG PGRPRYSFLD LFRARDNMRG RTTVGLGLVL FQQLTGQPNV
260 270 280 290 300
LCYASTIFSS VGFHGGSSAV LASVGLGAVK VAATLTAMGL VDRAGRRALL
310 320 330 340 350
LAGCALMALS VSGIGLVSFA VPMDSGPSCL AVPNATGQTG LPGDSGLLQD
360 370 380 390 400
SSLPPIPRTN EDQREPILST AKKTKPHPRS GDPSAPPRLA LSSALPGPPL
410 420 430 440 450
PARGHALLRW TALLCLMVFV SAFSFGFGPV TWLVLSEIYP VEIRGRAFAF
460 470 480 490 500
CNSFNWAANL FISLSFLDLI GTIGLSWTFL LYGLTAVLGL GFIYLFVPET
510 520 530 540
KGQSLAEIDQ QFQKRRFTLS FGHRQNSTGI PYSRIEISAA S
Length:541
Mass (Da):56,911
Last modified:June 1, 2001 - v2
Checksum:i6D644525FA136908
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti81 – 811S → R in ATS. 1 Publication
VAR_029535
Natural varianti106 – 1061A → S.
Corresponds to variant rs6094438 [ dbSNP | Ensembl ].
VAR_029536
Natural varianti132 – 1321R → W in ATS. 1 Publication
VAR_042417
Natural varianti142 – 1421G → V in ATS. 1 Publication
VAR_042418
Natural varianti206 – 2061A → T Associated with lower insulin level.
Corresponds to variant rs2235491 [ dbSNP | Ensembl ].
VAR_029335
Natural varianti225 – 2251R → H.
Corresponds to variant rs34295241 [ dbSNP | Ensembl ].
VAR_042419
Natural varianti231 – 2311R → Q in ATS. 1 Publication
VAR_042420
Natural varianti246 – 2461G → E in ATS. 1 Publication
VAR_042421
Natural varianti426 – 4261G → W in ATS. 1 Publication
VAR_042422
Natural varianti437 – 4371E → K in ATS. 1 Publication
VAR_042423
Natural varianti445 – 4451G → E in ATS.
VAR_042424
Natural varianti518 – 5181T → A.
Corresponds to variant rs6018008 [ dbSNP | Ensembl ].
VAR_024652
Natural varianti537 – 5371I → V.
Corresponds to variant rs7348121 [ dbSNP | Ensembl ].
VAR_029537

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321240 mRNA. Translation: AAK26294.1.
AF248053 mRNA. Translation: AAK31911.1.
AL137188 mRNA. Translation: CAB69822.2.
AK290961 mRNA. Translation: BAF83650.1.
AL031055 Genomic DNA. Translation: CAA19926.2.
CH471077 Genomic DNA. Translation: EAW75724.1.
BC101657 mRNA. Translation: AAI01658.1.
BC113423 mRNA. Translation: AAI13424.1.
CCDSiCCDS13402.1.
RefSeqiNP_110404.1. NM_030777.3.
UniGeneiHs.305971.

Genome annotation databases

EnsembliENST00000359271; ENSP00000352216; ENSG00000197496.
GeneIDi81031.
KEGGihsa:81031.
UCSCiuc002xsl.3. human.

Polymorphism and mutation databases

BioMutaiSLC2A10.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321240 mRNA. Translation: AAK26294.1.
AF248053 mRNA. Translation: AAK31911.1.
AL137188 mRNA. Translation: CAB69822.2.
AK290961 mRNA. Translation: BAF83650.1.
AL031055 Genomic DNA. Translation: CAA19926.2.
CH471077 Genomic DNA. Translation: EAW75724.1.
BC101657 mRNA. Translation: AAI01658.1.
BC113423 mRNA. Translation: AAI13424.1.
CCDSiCCDS13402.1.
RefSeqiNP_110404.1. NM_030777.3.
UniGeneiHs.305971.

3D structure databases

ProteinModelPortaliO95528.
SMRiO95528. Positions 27-320, 412-509.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123350. 1 interaction.

Protein family/group databases

TCDBi2.A.1.1.59. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteiO95528.

Polymorphism and mutation databases

BioMutaiSLC2A10.

Proteomic databases

MaxQBiO95528.
PaxDbiO95528.
PRIDEiO95528.

Protocols and materials databases

DNASUi81031.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359271; ENSP00000352216; ENSG00000197496.
GeneIDi81031.
KEGGihsa:81031.
UCSCiuc002xsl.3. human.

Organism-specific databases

CTDi81031.
GeneCardsiGC20P045338.
HGNCiHGNC:13444. SLC2A10.
HPAiHPA041015.
HPA055673.
MIMi208050. phenotype.
606145. gene.
neXtProtiNX_O95528.
Orphaneti3342. Arterial tortuosity syndrome.
PharmGKBiPA37769.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00590000083062.
HOGENOMiHOG000202868.
HOVERGENiHBG051858.
InParanoidiO95528.
KOiK08147.
OMAiSCLEQEF.
OrthoDBiEOG75B852.
PhylomeDBiO95528.
TreeFamiTF332408.

Enzyme and pathway databases

ReactomeiREACT_19343. Facilitative Na+-independent glucose transporters.

Miscellaneous databases

ChiTaRSiSLC2A10. human.
GeneWikiiSLC2A10.
GenomeRNAii81031.
NextBioi71362.
PROiO95528.
SOURCEiSearch...

Gene expression databases

BgeeiO95528.
CleanExiHS_SLC2A10.
ExpressionAtlasiO95528. baseline and differential.
GenevestigatoriO95528.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel member of the GLUT family of transporters, SLC2A10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility."
    McVie-Wylie A.J., Lamson D.R., Chen Y.T.
    Genomics 72:113-117(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1."
    Dawson P.A., Mychaleckyj J.C., Fossey S.C., Mihic S.J., Craddock A.L., Bowden D.W.
    Mol. Genet. Metab. 74:186-199(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, CHARACTERIZATION.
  3. Stavrides G.S., Hashim Y., Huckle E.J., Deloukas P.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  8. "Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits."
    Andersen G., Rose C.S., Hamid Y.H., Drivsholm T., Borch-Johnsen K., Hansen T., Pedersen O.
    Diabetes 52:2445-2448(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION OF VARIANT THR-206 WITH LOWER SERUM INSULIN LEVEL.
  9. Cited for: VARIANT ATS ARG-81, SUBCELLULAR LOCATION.
  10. Cited for: VARIANTS ATS TRP-132; VAL-142; GLN-231; GLU-246; TRP-426 AND LYS-437.

Entry informationi

Entry nameiGTR10_HUMAN
AccessioniPrimary (citable) accession number: O95528
Secondary accession number(s): A8K4J6, Q3MIX5, Q9H4I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 2001
Last modified: April 29, 2015
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.