O95528 (GTR10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 2, facilitated glucose transporter member 10

Alternative name(s):
Glucose transporter type 10
Short name=GLUT-10

Gene names

Name:	SLC2A10
Synonyms:	GLUT10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	541 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Facilitative glucose transporter.
Subcellular location	Endomembrane system; Multi-pass membrane protein. Cytoplasm › perinuclear region Ref.9.
Tissue specificity	Widely expressed; highest levels in liver and pancreas. Ref.2
Involvement in disease	Arterial tortuosity syndrome (ATS) [MIM:208050]: An autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.10
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]
Biophysicochemical properties	Kinetic parameters: KM=0.28 mM for 2-deoxy-D-glucose

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Polymorphism
Disease	Disease mutation
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glucose transport Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Traceable author statement. Source: Reactome
Molecular_function	sugar:hydrogen symporter activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 541	541	Solute carrier family 2, facilitated glucose transporter member 10		PRO_0000050379
Regions
	Topological domain	1 – 15	15	Cytoplasmic Potential
	Transmembrane	16 – 36	21	Helical; Name=1; Potential
	Topological domain	37 – 48	12	Extracellular Potential
	Transmembrane	49 – 69	21	Helical; Name=2; Potential
	Topological domain	70 – 77	8	Cytoplasmic Potential
	Transmembrane	78 – 98	21	Helical; Name=3; Potential
	Topological domain	99 – 106	8	Extracellular Potential
	Transmembrane	107 – 127	21	Helical; Name=4; Potential
	Topological domain	128 – 134	7	Cytoplasmic Potential
	Transmembrane	135 – 155	21	Helical; Name=5; Potential
	Topological domain	156 – 166	11	Extracellular Potential
	Transmembrane	167 – 187	21	Helical; Name=6; Potential
	Topological domain	188 – 233	46	Cytoplasmic Potential
	Transmembrane	234 – 254	21	Helical; Name=7; Potential
	Topological domain	255 – 269	15	Extracellular Potential
	Transmembrane	270 – 290	21	Helical; Name=8; Potential
	Topological domain	291 – 298	8	Cytoplasmic Potential
	Transmembrane	299 – 319	21	Helical; Name=9; Potential
	Topological domain	320 – 414	95	Extracellular Potential
	Transmembrane	415 – 435	21	Helical; Name=10; Potential
	Topological domain	436 – 445	10	Cytoplasmic Potential
	Transmembrane	446 – 466	21	Helical; Name=11; Potential
	Topological domain	467 – 476	10	Extracellular Potential
	Transmembrane	477 – 497	21	Helical; Name=12; Potential
	Topological domain	498 – 541	44	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	334	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	81	1	S → R in ATS. Ref.9		VAR_029535
	Natural variant	106	1	A → S. Corresponds to variant rs6094438 [ dbSNP | Ensembl ].		VAR_029536
	Natural variant	132	1	R → W in ATS. Ref.10		VAR_042417
	Natural variant	142	1	G → V in ATS. Ref.10		VAR_042418
	Natural variant	206	1	A → T Associated with lower insulin level. Ref.8 Corresponds to variant rs2235491 [ dbSNP | Ensembl ].		VAR_029335
	Natural variant	225	1	R → H. Corresponds to variant rs34295241 [ dbSNP | Ensembl ].		VAR_042419
	Natural variant	231	1	R → Q in ATS. Ref.10		VAR_042420
	Natural variant	246	1	G → E in ATS. Ref.10		VAR_042421
	Natural variant	426	1	G → W in ATS. Ref.10		VAR_042422
	Natural variant	437	1	E → K in ATS. Ref.10		VAR_042423
	Natural variant	445	1	G → E in ATS.		VAR_042424
	Natural variant	518	1	T → A. Corresponds to variant rs6018008 [ dbSNP | Ensembl ].		VAR_024652
	Natural variant	537	1	I → V. Corresponds to variant rs7348121 [ dbSNP | Ensembl ].		VAR_029537

Sequences

	Sequence		Length	Mass (Da)
	O95528 [UniParc]. Last modified June 1, 2001. Version 2. Checksum: 6D644525FA136908	FASTA	541	56,911
	10 20 30 40 50 60 MGHSPPVLPL CASVSLLGGL TFGYELAVIS GALLPLQLDF GLSCLEQEFL VGSLLLGALL 70 80 90 100 110 120 ASLVGGFLID CYGRKQAILG SNLVLLAGSL TLGLAGSLAW LVLGRAVVGF AISLSSMACC 130 140 150 160 170 180 IYVSELVGPR QRGVLVSLYE AGITVGILLS YALNYALAGT PWGWRHMFGW ATAPAVLQSL 190 200 210 220 230 240 SLLFLPAGTD ETATHKDLIP LQGGEAPKLG PGRPRYSFLD LFRARDNMRG RTTVGLGLVL 250 260 270 280 290 300 FQQLTGQPNV LCYASTIFSS VGFHGGSSAV LASVGLGAVK VAATLTAMGL VDRAGRRALL 310 320 330 340 350 360 LAGCALMALS VSGIGLVSFA VPMDSGPSCL AVPNATGQTG LPGDSGLLQD SSLPPIPRTN 370 380 390 400 410 420 EDQREPILST AKKTKPHPRS GDPSAPPRLA LSSALPGPPL PARGHALLRW TALLCLMVFV 430 440 450 460 470 480 SAFSFGFGPV TWLVLSEIYP VEIRGRAFAF CNSFNWAANL FISLSFLDLI GTIGLSWTFL 490 500 510 520 530 540 LYGLTAVLGL GFIYLFVPET KGQSLAEIDQ QFQKRRFTLS FGHRQNSTGI PYSRIEISAA S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a novel member of the GLUT family of transporters, SLC2A10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility." McVie-Wylie A.J., Lamson D.R., Chen Y.T. Genomics 72:113-117(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1." Dawson P.A., Mychaleckyj J.C., Fossey S.C., Mihic S.J., Craddock A.L., Bowden D.W. Mol. Genet. Metab. 74:186-199(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, CHARACTERIZATION.
[3]	Stavrides G.S., Hashim Y., Huckle E.J., Deloukas P. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[8]	"Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits." Andersen G., Rose C.S., Hamid Y.H., Drivsholm T., Borch-Johnsen K., Hansen T., Pedersen O. Diabetes 52:2445-2448(2003) [PubMed] [Europe PMC] [Abstract] Cited for: ASSOCIATION OF VARIANT THR-206 WITH LOWER SERUM INSULIN LEVEL.
[9]	"Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome." Coucke P.J., Willaert A., Wessels M.W., Callewaert B., Zoppi N., De Backer J., Fox J.E., Mancini G.M.S., Kambouris M., Gardella R., Facchetti F., Willems P.J., Forsyth R., Dietz H.C., Barlati S., Colombi M., Loeys B., De Paepe A. Nat. Genet. 38:452-457(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT ATS ARG-81, SUBCELLULAR LOCATION.
[10]	"Arterial tortuosity syndrome: clinical and molecular findings in 12 newly identified families." Callewaert B.L., Willaert A., Kerstjens-Frederikse W.S., De Backer J., Devriendt K., Albrecht B., Ramos-Arroyo M.A., Doco-Fenzy M., Hennekam R.C.M., Pyeritz R.E., Krogmann O.N., Gillessen-kaesbach G., Wakeling E.L., Nik-zainal S., Francannet C., Mauran P., Booth C., Barrow M. , Dekens R., Loeys B.L., Coucke P.J., De Paepe A.M. Hum. Mutat. 29:150-158(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS ATS TRP-132; VAL-142; GLN-231; GLU-246; TRP-426 AND LYS-437.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF321240 mRNA. Translation: AAK26294.1. AF248053 mRNA. Translation: AAK31911.1. AL137188 mRNA. Translation: CAB69822.2. AK290961 mRNA. Translation: BAF83650.1. AL031055 Genomic DNA. Translation: CAA19926.2. CH471077 Genomic DNA. Translation: EAW75724.1. BC101657 mRNA. Translation: AAI01658.1. BC113423 mRNA. Translation: AAI13424.1.
IPI	IPI00219424.
RefSeq	NP_110404.1. NM_030777.3.
UniGene	Hs.305971.
3D structure databases
ProteinModelPortal	O95528.
ModBase	Search...
Protein family/group databases
TCDB	2.A.1.1.59. major facilitator superfamily (MFS).
PTM databases
PhosphoSite	O95528.
Proteomic databases
PaxDb	O95528.
PRIDE	O95528.
Protocols and materials databases
DNASU	81031.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359271; ENSP00000352216; ENSG00000197496.
GeneID	81031.
KEGG	hsa:81031.
UCSC	uc002xsl.3. human.
Organism-specific databases
CTD	81031.
GeneCards	GC20P045338.
HGNC	HGNC:13444. SLC2A10.
HPA	HPA041015.
MIM	208050. phenotype. 606145. gene.
neXtProt	NX_O95528.
Orphanet	3342. Arterial tortuosity syndrome.
PharmGKB	PA37769.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0477.
HOGENOM	HOG000202868.
HOVERGEN	HBG051858.
InParanoid	O95528.
KO	K08147.
OMA	CYGRKQA.
OrthoDB	EOG4JQ3XH.
PhylomeDB	O95528.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	O95528.
Bgee	O95528.
CleanEx	HS_SLC2A10.
Genevestigator	O95528.
GermOnline	ENSG00000197496. Homo sapiens.
Family and domain databases
InterPro	IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR005828. Sub_transporter. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
Pfam	PF00083. Sugar_tr. 2 hits. [Graphical view]
PRINTS	PR00171. SUGRTRNSPORT.
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 2 hits. PS00217. SUGAR_TRANSPORT_2. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC2A10. human.
GenomeRNAi	81031.
NextBio	71362.
SOURCE	Search...

Entry information

Entry name

GTR10_HUMAN

Accession

Primary (citable) accession number: O95528
Secondary accession number(s): A8K4J6, Q3MIX5, Q9H4I6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 109 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.