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O95528

- GTR10_HUMAN

UniProt

O95528 - GTR10_HUMAN

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Protein
Solute carrier family 2, facilitated glucose transporter member 10
Gene
SLC2A10, GLUT10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter.

Kineticsi

  1. KM=0.28 mM for 2-deoxy-D-glucose

GO - Molecular functioni

  1. sugar:proton symporter activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. glucose transport Source: UniProtKB
  2. proton transport Source: GOC
  3. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiREACT_19343. Facilitative Na+-independent glucose transporters.

Protein family/group databases

TCDBi2.A.1.1.59. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 10
Alternative name(s):
Glucose transporter type 10
Short name:
GLUT-10
Gene namesi
Name:SLC2A10
Synonyms:GLUT10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:13444. SLC2A10.

Subcellular locationi

Endomembrane system; Multi-pass membrane protein. Cytoplasmperinuclear region 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei16 – 3621Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini37 – 4812Extracellular Reviewed prediction
Add
BLAST
Transmembranei49 – 6921Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini70 – 778Cytoplasmic Reviewed prediction
Transmembranei78 – 9821Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini99 – 1068Extracellular Reviewed prediction
Transmembranei107 – 12721Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini128 – 1347Cytoplasmic Reviewed prediction
Transmembranei135 – 15521Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini156 – 16611Extracellular Reviewed prediction
Add
BLAST
Transmembranei167 – 18721Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini188 – 23346Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei234 – 25421Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini255 – 26915Extracellular Reviewed prediction
Add
BLAST
Transmembranei270 – 29021Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini291 – 2988Cytoplasmic Reviewed prediction
Transmembranei299 – 31921Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini320 – 41495Extracellular Reviewed prediction
Add
BLAST
Transmembranei415 – 43521Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini436 – 44510Cytoplasmic Reviewed prediction
Transmembranei446 – 46621Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini467 – 47610Extracellular Reviewed prediction
Transmembranei477 – 49721Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini498 – 54144Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. endomembrane system Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB
  4. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Arterial tortuosity syndrome (ATS) [MIM:208050]: An autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti81 – 811S → R in ATS. 1 Publication
VAR_029535
Natural varianti132 – 1321R → W in ATS. 1 Publication
VAR_042417
Natural varianti142 – 1421G → V in ATS. 1 Publication
VAR_042418
Natural varianti231 – 2311R → Q in ATS. 1 Publication
VAR_042420
Natural varianti246 – 2461G → E in ATS. 1 Publication
VAR_042421
Natural varianti426 – 4261G → W in ATS. 1 Publication
VAR_042422
Natural varianti437 – 4371E → K in ATS. 1 Publication
VAR_042423
Natural varianti445 – 4451G → E in ATS.
VAR_042424

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi208050. phenotype.
Orphaneti3342. Arterial tortuosity syndrome.
PharmGKBiPA37769.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541Solute carrier family 2, facilitated glucose transporter member 10
PRO_0000050379Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi334 – 3341N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO95528.
PaxDbiO95528.
PRIDEiO95528.

PTM databases

PhosphoSiteiO95528.

Expressioni

Tissue specificityi

Widely expressed; highest levels in liver and pancreas.1 Publication

Gene expression databases

ArrayExpressiO95528.
BgeeiO95528.
CleanExiHS_SLC2A10.
GenevestigatoriO95528.

Organism-specific databases

HPAiHPA041015.
HPA055673.

Interactioni

Protein-protein interaction databases

BioGridi123350. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO95528.
SMRiO95528. Positions 27-320, 412-509.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOGENOMiHOG000202868.
HOVERGENiHBG051858.
InParanoidiO95528.
KOiK08147.
OMAiCYGRKQA.
OrthoDBiEOG75B852.
PhylomeDBiO95528.
TreeFamiTF332408.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95528-1 [UniParc]FASTAAdd to Basket

« Hide

MGHSPPVLPL CASVSLLGGL TFGYELAVIS GALLPLQLDF GLSCLEQEFL    50
VGSLLLGALL ASLVGGFLID CYGRKQAILG SNLVLLAGSL TLGLAGSLAW 100
LVLGRAVVGF AISLSSMACC IYVSELVGPR QRGVLVSLYE AGITVGILLS 150
YALNYALAGT PWGWRHMFGW ATAPAVLQSL SLLFLPAGTD ETATHKDLIP 200
LQGGEAPKLG PGRPRYSFLD LFRARDNMRG RTTVGLGLVL FQQLTGQPNV 250
LCYASTIFSS VGFHGGSSAV LASVGLGAVK VAATLTAMGL VDRAGRRALL 300
LAGCALMALS VSGIGLVSFA VPMDSGPSCL AVPNATGQTG LPGDSGLLQD 350
SSLPPIPRTN EDQREPILST AKKTKPHPRS GDPSAPPRLA LSSALPGPPL 400
PARGHALLRW TALLCLMVFV SAFSFGFGPV TWLVLSEIYP VEIRGRAFAF 450
CNSFNWAANL FISLSFLDLI GTIGLSWTFL LYGLTAVLGL GFIYLFVPET 500
KGQSLAEIDQ QFQKRRFTLS FGHRQNSTGI PYSRIEISAA S 541
Length:541
Mass (Da):56,911
Last modified:June 1, 2001 - v2
Checksum:i6D644525FA136908
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti81 – 811S → R in ATS. 1 Publication
VAR_029535
Natural varianti106 – 1061A → S.
Corresponds to variant rs6094438 [ dbSNP | Ensembl ].
VAR_029536
Natural varianti132 – 1321R → W in ATS. 1 Publication
VAR_042417
Natural varianti142 – 1421G → V in ATS. 1 Publication
VAR_042418
Natural varianti206 – 2061A → T Associated with lower insulin level. 1 Publication
Corresponds to variant rs2235491 [ dbSNP | Ensembl ].
VAR_029335
Natural varianti225 – 2251R → H.
Corresponds to variant rs34295241 [ dbSNP | Ensembl ].
VAR_042419
Natural varianti231 – 2311R → Q in ATS. 1 Publication
VAR_042420
Natural varianti246 – 2461G → E in ATS. 1 Publication
VAR_042421
Natural varianti426 – 4261G → W in ATS. 1 Publication
VAR_042422
Natural varianti437 – 4371E → K in ATS. 1 Publication
VAR_042423
Natural varianti445 – 4451G → E in ATS.
VAR_042424
Natural varianti518 – 5181T → A.
Corresponds to variant rs6018008 [ dbSNP | Ensembl ].
VAR_024652
Natural varianti537 – 5371I → V.
Corresponds to variant rs7348121 [ dbSNP | Ensembl ].
VAR_029537

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF321240 mRNA. Translation: AAK26294.1.
AF248053 mRNA. Translation: AAK31911.1.
AL137188 mRNA. Translation: CAB69822.2.
AK290961 mRNA. Translation: BAF83650.1.
AL031055 Genomic DNA. Translation: CAA19926.2.
CH471077 Genomic DNA. Translation: EAW75724.1.
BC101657 mRNA. Translation: AAI01658.1.
BC113423 mRNA. Translation: AAI13424.1.
CCDSiCCDS13402.1.
RefSeqiNP_110404.1. NM_030777.3.
UniGeneiHs.305971.

Genome annotation databases

EnsembliENST00000359271; ENSP00000352216; ENSG00000197496.
GeneIDi81031.
KEGGihsa:81031.
UCSCiuc002xsl.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF321240 mRNA. Translation: AAK26294.1 .
AF248053 mRNA. Translation: AAK31911.1 .
AL137188 mRNA. Translation: CAB69822.2 .
AK290961 mRNA. Translation: BAF83650.1 .
AL031055 Genomic DNA. Translation: CAA19926.2 .
CH471077 Genomic DNA. Translation: EAW75724.1 .
BC101657 mRNA. Translation: AAI01658.1 .
BC113423 mRNA. Translation: AAI13424.1 .
CCDSi CCDS13402.1.
RefSeqi NP_110404.1. NM_030777.3.
UniGenei Hs.305971.

3D structure databases

ProteinModelPortali O95528.
SMRi O95528. Positions 27-320, 412-509.
ModBasei Search...

Protein-protein interaction databases

BioGridi 123350. 1 interaction.

Protein family/group databases

TCDBi 2.A.1.1.59. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei O95528.

Proteomic databases

MaxQBi O95528.
PaxDbi O95528.
PRIDEi O95528.

Protocols and materials databases

DNASUi 81031.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359271 ; ENSP00000352216 ; ENSG00000197496 .
GeneIDi 81031.
KEGGi hsa:81031.
UCSCi uc002xsl.3. human.

Organism-specific databases

CTDi 81031.
GeneCardsi GC20P045338.
HGNCi HGNC:13444. SLC2A10.
HPAi HPA041015.
HPA055673.
MIMi 208050. phenotype.
606145. gene.
neXtProti NX_O95528.
Orphaneti 3342. Arterial tortuosity syndrome.
PharmGKBi PA37769.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
HOGENOMi HOG000202868.
HOVERGENi HBG051858.
InParanoidi O95528.
KOi K08147.
OMAi CYGRKQA.
OrthoDBi EOG75B852.
PhylomeDBi O95528.
TreeFami TF332408.

Enzyme and pathway databases

Reactomei REACT_19343. Facilitative Na+-independent glucose transporters.

Miscellaneous databases

ChiTaRSi SLC2A10. human.
GeneWikii SLC2A10.
GenomeRNAii 81031.
NextBioi 71362.
PROi O95528.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95528.
Bgeei O95528.
CleanExi HS_SLC2A10.
Genevestigatori O95528.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 2 hits.
[Graphical view ]
PRINTSi PR00171. SUGRTRNSPORT.
SUPFAMi SSF103473. SSF103473. 2 hits.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel member of the GLUT family of transporters, SLC2A10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility."
    McVie-Wylie A.J., Lamson D.R., Chen Y.T.
    Genomics 72:113-117(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1."
    Dawson P.A., Mychaleckyj J.C., Fossey S.C., Mihic S.J., Craddock A.L., Bowden D.W.
    Mol. Genet. Metab. 74:186-199(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, CHARACTERIZATION.
  3. Stavrides G.S., Hashim Y., Huckle E.J., Deloukas P.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  8. "Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits."
    Andersen G., Rose C.S., Hamid Y.H., Drivsholm T., Borch-Johnsen K., Hansen T., Pedersen O.
    Diabetes 52:2445-2448(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION OF VARIANT THR-206 WITH LOWER SERUM INSULIN LEVEL.
  9. Cited for: VARIANT ATS ARG-81, SUBCELLULAR LOCATION.
  10. Cited for: VARIANTS ATS TRP-132; VAL-142; GLN-231; GLU-246; TRP-426 AND LYS-437.

Entry informationi

Entry nameiGTR10_HUMAN
AccessioniPrimary (citable) accession number: O95528
Secondary accession number(s): A8K4J6, Q3MIX5, Q9H4I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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