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Protein

PRAME family member 1

Gene

PRAMEF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PRAME family member 1Curated
Gene namesi
Name:PRAMEF1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28840. PRAMEF1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671138.

Polymorphism and mutation databases

BioMutaiPRAMEF1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474PRAME family member 1PRO_0000156975Add
BLAST

Proteomic databases

PaxDbiO95521.
PRIDEiO95521.

PTM databases

iPTMnetiO95521.
PhosphoSiteiO95521.

Expressioni

Gene expression databases

BgeeiO95521.
GenevisibleiO95521. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000332134.

Structurei

3D structure databases

ProteinModelPortaliO95521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati319 – 34224LRR 1Add
BLAST
Repeati348 – 37528LRR 2Add
BLAST

Sequence similaritiesi

Belongs to the PRAME family.Curated
Contains 2 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IUI2. Eukaryota.
ENOG4110PY1. LUCA.
GeneTreeiENSGT00760000119028.
HOGENOMiHOG000231112.
HOVERGENiHBG006326.
InParanoidiO95521.
OrthoDBiEOG7KSX88.
TreeFamiTF332708.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR026271. PRAME_family.
[Graphical view]
PIRSFiPIRSF038286. PRAME. 1 hit.

Sequencei

Sequence statusi: Complete.

O95521-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIQAPPRLL ELAGQSLLRD QALSISAMEE LPRVLYLPLF MEAFSRRHFQ
60 70 80 90 100
TLTVMVQAWP FTCLPLGSLM KTLHLETLKA LLEGLHMLLT QKDRPRRWKL
110 120 130 140 150
QVLDLRDVDE NFWARWPGAW ALSCFPETTS KRQTAEDCPR MGEHQPLKVF
160 170 180 190 200
IDICLKEIPQ DECLRYLFQW VYQRRGLVHL CCSKLVNYLT PIKYLRKSLK
210 220 230 240 250
IIYLNSIQEL EIRNMSWPRL IRKLRCYLKE MKNLRKLVFS RCHHYTSDNE
260 270 280 290 300
LEGRLVAKFS SVFLRLEHLQ LLKIKLITFF SGHLEQLIRC LQNPLENLEL
310 320 330 340 350
TYGYLLEEDM KCLSQYPSLG YLKHLNLSYV LLFRISLEPL GALLEKIAAS
360 370 380 390 400
LKTLILEGCQ IHYSQLSAIL PGLSRCSQLT TFYFGRNCMS IDALKDLLRH
410 420 430 440 450
TSGLSKLSLE TYPAPEESLN SLVRVNWEIF TPLRAELMCT LREVRQPKRI
460 470
FIGPTPCPSC GSSPSEELEL HLCC
Length:474
Mass (Da):55,149
Last modified:January 20, 2016 - v3
Checksum:i1AB24ED3783A6ECC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti204 – 2041L → M.
Corresponds to variant rs1063767 [ dbSNP | Ensembl ].
VAR_053604
Natural varianti213 – 2131R → H.
Corresponds to variant rs1063769 [ dbSNP | Ensembl ].
VAR_062138
Natural varianti218 – 2181P → S.
Corresponds to variant rs1769774 [ dbSNP | Ensembl ].
VAR_060091
Natural varianti252 – 2521E → Q.1 Publication
Corresponds to variant rs1063776 [ dbSNP | Ensembl ].
VAR_034396
Natural varianti302 – 3021Y → C.
Corresponds to variant rs17404799 [ dbSNP | Ensembl ].
VAR_034397
Natural varianti316 – 3161Y → F.
Corresponds to variant rs17039293 [ dbSNP | Ensembl ].
VAR_034398
Natural varianti372 – 3721G → A.1 Publication
Corresponds to variant rs1063795 [ dbSNP | Ensembl ].
VAR_060092
Natural varianti375 – 3751R → C.
Corresponds to variant rs17039307 [ dbSNP | Ensembl ].
VAR_034399
Natural varianti386 – 3861R → S.
Corresponds to variant rs1052908 [ dbSNP | Ensembl ].
VAR_053605

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049686 mRNA. Translation: CAB41257.1.
AC244670 Genomic DNA. No translation available.
AL022101, AL023753 Genomic DNA. Translation: CAI22990.1.
AL023753, AL022101 Genomic DNA. Translation: CAI19425.1.
CCDSiCCDS148.1.
RefSeqiNP_075389.2. NM_023013.4.
UniGeneiHs.454859.
Hs.744789.

Genome annotation databases

EnsembliENST00000332296; ENSP00000332134; ENSG00000116721.
GeneIDi65121.
UCSCiuc031tpg.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049686 mRNA. Translation: CAB41257.1.
AC244670 Genomic DNA. No translation available.
AL022101, AL023753 Genomic DNA. Translation: CAI22990.1.
AL023753, AL022101 Genomic DNA. Translation: CAI19425.1.
CCDSiCCDS148.1.
RefSeqiNP_075389.2. NM_023013.4.
UniGeneiHs.454859.
Hs.744789.

3D structure databases

ProteinModelPortaliO95521.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000332134.

PTM databases

iPTMnetiO95521.
PhosphoSiteiO95521.

Polymorphism and mutation databases

BioMutaiPRAMEF1.

Proteomic databases

PaxDbiO95521.
PRIDEiO95521.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332296; ENSP00000332134; ENSG00000116721.
GeneIDi65121.
UCSCiuc031tpg.1. human.

Organism-specific databases

CTDi65121.
GeneCardsiPRAMEF1.
HGNCiHGNC:28840. PRAMEF1.
neXtProtiNX_O95521.
PharmGKBiPA142671138.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUI2. Eukaryota.
ENOG4110PY1. LUCA.
GeneTreeiENSGT00760000119028.
HOGENOMiHOG000231112.
HOVERGENiHBG006326.
InParanoidiO95521.
OrthoDBiEOG7KSX88.
TreeFamiTF332708.

Miscellaneous databases

GenomeRNAii65121.
NextBioi67322.
PROiO95521.

Gene expression databases

BgeeiO95521.
GenevisibleiO95521. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR026271. PRAME_family.
[Graphical view]
PIRSFiPIRSF038286. PRAME. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Rhodes S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLN-252 AND ALA-372.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPRAM1_HUMAN
AccessioniPrimary (citable) accession number: O95521
Secondary accession number(s): Q9UQP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 20, 2016
Last modified: April 13, 2016
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.