Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O95502

- NPTXR_HUMAN

UniProt

O95502 - NPTXR_HUMAN

Protein

Neuronal pentraxin receptor

Gene

NPTXR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.By similarity

    Cofactori

    Binds 2 calcium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi347 – 3471Calcium 1By similarity
    Metal bindingi425 – 4251Calcium 1By similarity
    Metal bindingi425 – 4251Calcium 2By similarity
    Metal bindingi426 – 4261Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi427 – 4271Calcium 1By similarity
    Metal bindingi427 – 4271Calcium 2By similarity
    Metal bindingi437 – 4371Calcium 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuronal pentraxin receptor
    Gene namesi
    Name:NPTXR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:7954. NPTXR.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31740.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Neuronal pentraxin receptorPRO_0000162506Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing KLHL2.By similarity

    Keywords - PTMi

    Glycoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiO95502.
    PaxDbiO95502.
    PRIDEiO95502.

    Expressioni

    Gene expression databases

    BgeeiO95502.
    CleanExiHS_NPTXR.
    GenevestigatoriO95502.

    Organism-specific databases

    HPAiHPA001079.

    Interactioni

    Subunit structurei

    Heteropentamer with NPTX1 and/or NPTX2. Also binds taipoxin-associated calcium-binding protein 49 (TCBP49/RCN2). Interacts with KLHL2 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000327545.

    Structurei

    3D structure databases

    ProteinModelPortaliO95502.
    SMRiO95502. Positions 261-289, 295-480.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 22CytoplasmicSequence Analysis
    Topological domaini24 – 500477ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini296 – 500205PentaxinAdd
    BLAST

    Sequence similaritiesi

    Contains 1 pentaxin domain.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG315361.
    HOGENOMiHOG000231267.
    HOVERGENiHBG003608.
    InParanoidiO95502.
    OrthoDBiEOG74XS6F.
    PhylomeDBiO95502.
    TreeFamiTF330208.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view]
    PfamiPF00354. Pentaxin. 1 hit.
    [Graphical view]
    PRINTSiPR00895. PENTAXIN.
    SMARTiSM00159. PTX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O95502-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFLAVLLAA GMLAFLGAVI CIIASVPLAA SPARALPGGA DNASVASGAA    50
    ASPGPQRSLS ALHGAGGSAG PPALPGAPAA SAHPLPPGPL FSRFLCTPLA 100
    AACPSGAQQG DAAGAAPGER EELLLLQSTA EQLRQTALQQ EARIRADQDT 150
    IRELTGKLGR CESGLPRGLQ GAGPRRDTMA DGPWDSPALI LELEDAVRAL 200
    RDRIDRLEQE LPARVNLSAA PAPVSAVPTG LHSKMDQLEG QLLAQVLALE 250
    KERVALSHSS RRQRQEVEKE LDVLQGRVAE LEHGSSAYSP PDAFKISIPI 300
    RNNYMYARVR KALPELYAFT ACMWLRSRSS GTGQGTPFSY SVPGQANEIV 350
    LLEAGHEPME LLINDKVAQL PLSLKDNGWH HICIAWTTRD GLWSAYQDGE 400
    LQGSGENLAA WHPIKPHGIL ILGQEQDTLG GRFDATQAFV GDIAQFNLWD 450
    HALTPAQVLG IANCTAPLLG NVLPWEDKLV EAFGGATKAA FDVCKGRAKA 500
    Length:500
    Mass (Da):52,846
    Last modified:May 5, 2009 - v2
    Checksum:i831D12AB76ACCA00
    GO

    Sequence cautioni

    The sequence CAA15430.3 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL008583 Genomic DNA. Translation: CAA15430.3. Sequence problems.
    CCDSiCCDS33647.1.
    RefSeqiNP_055108.2. NM_014293.3.
    UniGeneiHs.91622.

    Genome annotation databases

    EnsembliENST00000333039; ENSP00000327545; ENSG00000221890.
    GeneIDi23467.
    KEGGihsa:23467.
    UCSCiuc003awk.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL008583 Genomic DNA. Translation: CAA15430.3 . Sequence problems.
    CCDSi CCDS33647.1.
    RefSeqi NP_055108.2. NM_014293.3.
    UniGenei Hs.91622.

    3D structure databases

    ProteinModelPortali O95502.
    SMRi O95502. Positions 261-289, 295-480.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000327545.

    Proteomic databases

    MaxQBi O95502.
    PaxDbi O95502.
    PRIDEi O95502.

    Protocols and materials databases

    DNASUi 23467.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333039 ; ENSP00000327545 ; ENSG00000221890 .
    GeneIDi 23467.
    KEGGi hsa:23467.
    UCSCi uc003awk.3. human.

    Organism-specific databases

    CTDi 23467.
    GeneCardsi GC22M039214.
    HGNCi HGNC:7954. NPTXR.
    HPAi HPA001079.
    MIMi 609474. gene.
    neXtProti NX_O95502.
    PharmGKBi PA31740.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315361.
    HOGENOMi HOG000231267.
    HOVERGENi HBG003608.
    InParanoidi O95502.
    OrthoDBi EOG74XS6F.
    PhylomeDBi O95502.
    TreeFami TF330208.

    Miscellaneous databases

    ChiTaRSi NPTXR. human.
    GeneWikii NPTXR.
    GenomeRNAii 23467.
    NextBioi 45789.
    PROi O95502.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95502.
    CleanExi HS_NPTXR.
    Genevestigatori O95502.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view ]
    Pfami PF00354. Pentaxin. 1 hit.
    [Graphical view ]
    PRINTSi PR00895. PENTAXIN.
    SMARTi SM00159. PTX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiNPTXR_HUMAN
    AccessioniPrimary (citable) accession number: O95502
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3