O95502 (NPTXR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuronal pentraxin receptor

Gene names

Name:

NPTXR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses By similarity.
Cofactor	Binds 2 calcium ions per subunit By similarity.
Subunit structure	Heteropentamer with NPTX1 and/or NPTX2. Also binds taipoxin-associated calcium-binding protein 49 (TCBP49/RCN2). Interacts with KLHL2 By similarity.
Subcellular location	Membrane; Single-pass type II membrane protein Potential.
Post-translational modification	Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing KLHL2 By similarity.
Sequence similarities	Contains 1 pentaxin domain.
Sequence caution	The sequence CAA15430.3 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
Molecular function	Receptor
PTM	Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Neuronal pentraxin receptor		PRO_0000162506
Regions
	Topological domain	1 – 2	2	Cytoplasmic Potential
	Transmembrane	3 – 23	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	24 – 500	477	Extracellular Potential
	Domain	296 – 500	205	Pentaxin
Sites
	Metal binding	347	1	Calcium 1 By similarity
	Metal binding	425	1	Calcium 1 By similarity
	Metal binding	425	1	Calcium 2 By similarity
	Metal binding	426	1	Calcium 1; via carbonyl oxygen By similarity
	Metal binding	427	1	Calcium 1 By similarity
	Metal binding	427	1	Calcium 2 By similarity
	Metal binding	437	1	Calcium 2 By similarity
Amino acid modifications
	Glycosylation	42	1	N-linked (GlcNAc...) Potential
	Glycosylation	216	1	N-linked (GlcNAc...) Potential
	Glycosylation	463	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O95502 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: 831D12AB76ACCA00	FASTA	500	52,846
	10 20 30 40 50 60 MKFLAVLLAA GMLAFLGAVI CIIASVPLAA SPARALPGGA DNASVASGAA ASPGPQRSLS 70 80 90 100 110 120 ALHGAGGSAG PPALPGAPAA SAHPLPPGPL FSRFLCTPLA AACPSGAQQG DAAGAAPGER 130 140 150 160 170 180 EELLLLQSTA EQLRQTALQQ EARIRADQDT IRELTGKLGR CESGLPRGLQ GAGPRRDTMA 190 200 210 220 230 240 DGPWDSPALI LELEDAVRAL RDRIDRLEQE LPARVNLSAA PAPVSAVPTG LHSKMDQLEG 250 260 270 280 290 300 QLLAQVLALE KERVALSHSS RRQRQEVEKE LDVLQGRVAE LEHGSSAYSP PDAFKISIPI 310 320 330 340 350 360 RNNYMYARVR KALPELYAFT ACMWLRSRSS GTGQGTPFSY SVPGQANEIV LLEAGHEPME 370 380 390 400 410 420 LLINDKVAQL PLSLKDNGWH HICIAWTTRD GLWSAYQDGE LQGSGENLAA WHPIKPHGIL 430 440 450 460 470 480 ILGQEQDTLG GRFDATQAFV GDIAQFNLWD HALTPAQVLG IANCTAPLLG NVLPWEDKLV 490 500 EAFGGATKAA FDVCKGRAKA

References

[1]

"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL008583 Genomic DNA. Translation: CAA15430.3. Sequence problems.
IPI	IPI00334238.
RefSeq	NP_055108.2. NM_014293.3.
UniGene	Hs.91622.
3D structure databases
ProteinModelPortal	O95502.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000327545.
Proteomic databases
PaxDb	O95502.
PRIDE	O95502.
Protocols and materials databases
DNASU	23467.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000333039; ENSP00000327545; ENSG00000221890.
GeneID	23467.
KEGG	hsa:23467.
UCSC	uc003awk.3. human.
Organism-specific databases
CTD	23467.
GeneCards	GC22M039214.
HGNC	HGNC:7954. NPTXR.
HPA	HPA001079.
MIM	609474. gene.
neXtProt	NX_O95502.
PharmGKB	PA31740.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG315361.
HOGENOM	HOG000231267.
HOVERGEN	HBG003608.
InParanoid	O95502.
OrthoDB	EOG4F1X3V.
Gene expression databases
Bgee	O95502.
CleanEx	HS_NPTXR.
Genevestigator	O95502.
GermOnline	ENSG00000183741. Homo sapiens.
Family and domain databases
Gene3D	2.60.120.200. 1 hit.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR001759. Pentaxin. [Graphical view]
Pfam	PF00354. Pentaxin. 1 hit. [Graphical view]
PRINTS	PR00895. PENTAXIN.
SMART	SM00159. PTX. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS00289. PENTAXIN. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NPTXR. human.
GenomeRNAi	23467.
NextBio	45789.
SOURCE	Search...

Entry information

Entry name

NPTXR_HUMAN

Accession

Primary (citable) accession number: O95502

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.