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O95502

- NPTXR_HUMAN

UniProt

O95502 - NPTXR_HUMAN

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Protein

Neuronal pentraxin receptor

Gene
NPTXR
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses By similarity.

Cofactori

Binds 2 calcium ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi347 – 3471Calcium 1 By similarity
Metal bindingi425 – 4251Calcium 1 By similarity
Metal bindingi425 – 4251Calcium 2 By similarity
Metal bindingi426 – 4261Calcium 1; via carbonyl oxygen By similarity
Metal bindingi427 – 4271Calcium 1 By similarity
Metal bindingi427 – 4271Calcium 2 By similarity
Metal bindingi437 – 4371Calcium 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin receptor
Gene namesi
Name:NPTXR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:7954. NPTXR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22Cytoplasmic Reviewed prediction
Transmembranei3 – 2321Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini24 – 500477Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31740.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Neuronal pentraxin receptorPRO_0000162506Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi216 – 2161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi463 – 4631N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing KLHL2 By similarity.

Keywords - PTMi

Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiO95502.
PaxDbiO95502.
PRIDEiO95502.

Expressioni

Gene expression databases

BgeeiO95502.
CleanExiHS_NPTXR.
GenevestigatoriO95502.

Organism-specific databases

HPAiHPA001079.

Interactioni

Subunit structurei

Heteropentamer with NPTX1 and/or NPTX2. Also binds taipoxin-associated calcium-binding protein 49 (TCBP49/RCN2). Interacts with KLHL2 By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000327545.

Structurei

3D structure databases

ProteinModelPortaliO95502.
SMRiO95502. Positions 261-289, 295-480.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini296 – 500205PentaxinAdd
BLAST

Sequence similaritiesi

Contains 1 pentaxin domain.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG315361.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiO95502.
OrthoDBiEOG74XS6F.
PhylomeDBiO95502.
TreeFamiTF330208.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001759. Pentaxin.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.

Sequencei

Sequence statusi: Complete.

O95502-1 [UniParc]FASTAAdd to Basket

« Hide

MKFLAVLLAA GMLAFLGAVI CIIASVPLAA SPARALPGGA DNASVASGAA    50
ASPGPQRSLS ALHGAGGSAG PPALPGAPAA SAHPLPPGPL FSRFLCTPLA 100
AACPSGAQQG DAAGAAPGER EELLLLQSTA EQLRQTALQQ EARIRADQDT 150
IRELTGKLGR CESGLPRGLQ GAGPRRDTMA DGPWDSPALI LELEDAVRAL 200
RDRIDRLEQE LPARVNLSAA PAPVSAVPTG LHSKMDQLEG QLLAQVLALE 250
KERVALSHSS RRQRQEVEKE LDVLQGRVAE LEHGSSAYSP PDAFKISIPI 300
RNNYMYARVR KALPELYAFT ACMWLRSRSS GTGQGTPFSY SVPGQANEIV 350
LLEAGHEPME LLINDKVAQL PLSLKDNGWH HICIAWTTRD GLWSAYQDGE 400
LQGSGENLAA WHPIKPHGIL ILGQEQDTLG GRFDATQAFV GDIAQFNLWD 450
HALTPAQVLG IANCTAPLLG NVLPWEDKLV EAFGGATKAA FDVCKGRAKA 500
Length:500
Mass (Da):52,846
Last modified:May 5, 2009 - v2
Checksum:i831D12AB76ACCA00
GO

Sequence cautioni

The sequence CAA15430.3 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL008583 Genomic DNA. Translation: CAA15430.3. Sequence problems.
CCDSiCCDS33647.1.
RefSeqiNP_055108.2. NM_014293.3.
UniGeneiHs.91622.

Genome annotation databases

EnsembliENST00000333039; ENSP00000327545; ENSG00000221890.
GeneIDi23467.
KEGGihsa:23467.
UCSCiuc003awk.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL008583 Genomic DNA. Translation: CAA15430.3 . Sequence problems.
CCDSi CCDS33647.1.
RefSeqi NP_055108.2. NM_014293.3.
UniGenei Hs.91622.

3D structure databases

ProteinModelPortali O95502.
SMRi O95502. Positions 261-289, 295-480.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000327545.

Proteomic databases

MaxQBi O95502.
PaxDbi O95502.
PRIDEi O95502.

Protocols and materials databases

DNASUi 23467.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333039 ; ENSP00000327545 ; ENSG00000221890 .
GeneIDi 23467.
KEGGi hsa:23467.
UCSCi uc003awk.3. human.

Organism-specific databases

CTDi 23467.
GeneCardsi GC22M039214.
HGNCi HGNC:7954. NPTXR.
HPAi HPA001079.
MIMi 609474. gene.
neXtProti NX_O95502.
PharmGKBi PA31740.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG315361.
HOGENOMi HOG000231267.
HOVERGENi HBG003608.
InParanoidi O95502.
OrthoDBi EOG74XS6F.
PhylomeDBi O95502.
TreeFami TF330208.

Miscellaneous databases

ChiTaRSi NPTXR. human.
GeneWikii NPTXR.
GenomeRNAii 23467.
NextBioi 45789.
PROi O95502.
SOURCEi Search...

Gene expression databases

Bgeei O95502.
CleanExi HS_NPTXR.
Genevestigatori O95502.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001759. Pentaxin.
[Graphical view ]
Pfami PF00354. Pentaxin. 1 hit.
[Graphical view ]
PRINTSi PR00895. PENTAXIN.
SMARTi SM00159. PTX. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNPTXR_HUMAN
AccessioniPrimary (citable) accession number: O95502
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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