Reviewed,
UniProtKB/Swiss-Prot O95498 (VNN2_HUMAN)
Last modified
November 25, 2008.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Vascular non-inflammatory molecule 2 Short name=Vanin-2 Alternative name(s): Glycosylphosphatidyl inositol-anchored protein GPI-80 Protein FOAP-4 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 520 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Probable hydrolase. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil. |
| Subcellular location | Cell membrane; Lipid-anchor › GPI-anchorPotential. |
| Tissue specificity | Expressed in spleen, thymus, peripheral blood lymphocytes and kidney. |
| Sequence similarities | Belongs to the CN hydrolase family. BTD/VNN subfamily. Contains 1 CN hydrolase domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Signal |
| Molecular function | Hydrolase |
| PTM | GPI-anchor Glycoprotein Lipoprotein |
Gene Ontology (GO) | |
| Biological process | cell motion Ref.1 Traceable author statement. Source: ProtInc nitrogen compound metabolic processInferred from electronic annotation. Source: InterPro pantothenate metabolic processInferred from direct assay. Source: UniProtKB |
| Cellular component | anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | pantetheine hydrolase activity Inferred from direct assay. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 22 | 22 | Potential | ||||||
| Chain | 23 – 493 | 471 | Vascular non-inflammatory molecule 2 | PRO_0000019718 | |||||
| Propeptide | 494 – 520 | 27 | Removed in mature form Potential | PRO_0000019719 | |||||
Regions | |||||||||
| Domain | 26 – 328 | 303 | CN hydrolase | ||||||
| Compositional bias | 393 – 396 | 4 | Poly-Arg | ||||||
Amino acid modifications | |||||||||
| Lipidation | 493 | 1 | GPI-anchor amidated cysteine Potential | ||||||
| Glycosylation | 39 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 273 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 347 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 357 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 411 | 1 | N-linked (GlcNAc...) | ||||||
| Glycosylation | 468 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 17 | 1 | T → N | VAR_025177 | |||||
| Natural variant | 30 | 1 | V → A: dbSNP rs2294760. | VAR_031261 | |||||
| Natural variant | 112 | 1 | D → E | VAR_025178 | |||||
| Natural variant | 241 | 1 | V → I: dbSNP rs33920182. | VAR_025179 | |||||
| Natural variant | 349 | 1 | T → S | VAR_025180 | |||||
| Natural variant | 404 | 1 | L → M: dbSNP rs4895944. | VAR_023530 | |||||
Experimental info | |||||||||
| Sequence conflict | 218 | 1 | D → Y in CAA10569. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6." Galland F., Malergue F., Bazin H., Mattei M.-G., Aurrand-Lions M., Theillet C., Naquet P. Genomics 53:203-213(1998) [PubMed: 9790769] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-404. Tissue: Kidney. |
| [2] | "A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: a possible role for regulation of neutrophil adherence and migration." Suzuki K., Watanabe T., Sakurai S., Ohtake K., Kinoshita T., Araki A., Fujita T., Takei H., Takeda Y., Sato Y., Yamashita T., Araki Y., Sendo F. J. Immunol. 162:4277-4284(1999) [PubMed: 10201959] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-404. Tissue: Peripheral blood. |
| [3] | "Homo sapiens mRNA for FOAP-4 protein, complete cds." Takayama K., Fujii Y., Tsuritani K., Yajima Y., Amemiya T., Ukai Y., Naito K., Kawaguchi A. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-404. Tissue: Blood. |
| [4] | "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)." Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N., Rajkumar N., Willa H.T., Daniels M., Downing T.K., Stanaway I.B., Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J., Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-17; GLU-112; ILE-241; SER-349 AND MET-404. |
| [5] | "The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. Beck S.Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-404. |
| [7] | "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-411, MASS SPECTROMETRY. Tissue: Plasma. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AJ132100 mRNA. Translation: CAA10569.1. D89974 mRNA. Translation: BAA82525.1. AB026705 mRNA. Translation: BAB61019.1. DQ249347 Genomic DNA. Translation: ABB72673.1. AL032821 Genomic DNA. Translation: CAB40076.1. BC126145 mRNA. Translation: AAI26146.1. BC126147 mRNA. Translation: AAI26148.1. | |
| RefSeq | NP_004656.2. NP_511043.1. |
| UniGene | Hs.293130 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | O95498. |
Polymorphism databases | |
| NIEHS-SNPs | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000112303. Homo sapiens. [Contig view] |
| GeneID | 8875. |
| KEGG | hsa:8875. |
Organism-specific databases | |
| H-InvDB | HIX0032748. |
| HGNC | HGNC:12706. VNN2. |
| MIM | 603571. gene. |
| PharmGKB | PA37322. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | O95498. |
| HOVERGEN | O95498. |
Gene expression databases | |
| ArrayExpress | O95498. |
| CleanEx | HS_VNN2. |
| GermOnline | ENSG00000112303. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR012101. Biotinidase_euk. IPR003010. Ntlse/CNhydtse. [Graphical view] |
| Gene3D | G3DSA:3.60.110.10. Ntlse/CNhydtse. 1 hit. |
| PANTHER | PTHR10609. Biotinidase_euk. 1 hit. |
| Pfam | PF00795. CN_hydrolase. 1 hit. [Graphical view] |
| PIRSF | PIRSF011861. Biotinidase. 1 hit. |
| PROSITE | PS50263. CN_HYDROLASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 33319. |
| SOURCE | Search... |
Entry information
| Entry name | VNN2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O95498 Secondary accession number(s): A0AUZ3 Q9UMW2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 6 Human chromosome 6: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


