O95498 (VNN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vascular non-inflammatory molecule 2
Short name=Vanin-2
EC=3.5.1.92

Alternative name(s):
Glycosylphosphatidyl inositol-anchored protein GPI-80
Protein FOAP-4

Gene names

Name:

VNN2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	520 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil. Ref.9
Catalytic activity	(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor Potential.
Tissue specificity	widely expressed with higher expression in spleen and blood. Ref.11
Sequence similarities	Belongs to the CN hydrolase family. BTD/VNN subfamily. Contains 1 CN hydrolase domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Molecular function	Hydrolase
PTM	GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular component movement Traceable author statement. Source: ProtInc pantothenate metabolic process Inferred from direct assay Ref.9. Source: BHF-UCL
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	pantetheine hydrolase activity Inferred from direct assay Ref.9. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O95498-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O95498-2)

Also known as: GPI-80 variant protein 3;

The sequence of this isoform differs from the canonical sequence as follows:
     180-400: Missing.

Isoform 3 (identifier: O95498-3)

Also known as: GPI-80 variant protein 2;

The sequence of this isoform differs from the canonical sequence as follows:
     180-192: YHLYSEPQFNVPE → ETLQSVKRSFAVI
     193-520: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 4 (identifier: O95498-4)

Also known as: GPI-80 variant protein 1;

The sequence of this isoform differs from the canonical sequence as follows:
     180-195: YHLYSEPQFNVPEKPE → EVVFMHQMVPKCIIMT
     196-520: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 5 (identifier: O95498-5)

Also known as: GPI-80 variant protein 4;

The sequence of this isoform differs from the canonical sequence as follows:
     116-119: FGHT → SAQC
     120-520: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 493	471	Vascular non-inflammatory molecule 2		PRO_0000019718
	Propeptide	494 – 520	27	Removed in mature form Potential		PRO_0000019719
Regions
	Domain	26 – 328	303	CN hydrolase
	Compositional bias	393 – 396	4	Poly-Arg
Amino acid modifications
	Lipidation	493	1	GPI-anchor amidated cysteine Potential
	Glycosylation	39	1	N-linked (GlcNAc...) Potential
	Glycosylation	273	1	N-linked (GlcNAc...) Potential
	Glycosylation	347	1	N-linked (GlcNAc...) Potential
	Glycosylation	357	1	N-linked (GlcNAc...) Potential
	Glycosylation	411	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	468	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	116 – 119	4	FGHT → SAQC in isoform 5.		VSP_038554
	Alternative sequence	120 – 520	401	Missing in isoform 5.		VSP_038555
	Alternative sequence	180 – 400	221	Missing in isoform 2.		VSP_038557
	Alternative sequence	180 – 195	16	YHLYS…PEKPE → EVVFMHQMVPKCIIMT in isoform 4.		VSP_038556
	Alternative sequence	180 – 192	13	YHLYS…FNVPE → ETLQSVKRSFAVI in isoform 3.		VSP_038558
	Alternative sequence	193 – 520	328	Missing in isoform 3.		VSP_038559
	Alternative sequence	196 – 520	325	Missing in isoform 4.		VSP_038560
	Natural variant	17	1	T → N. Ref.6 Corresponds to variant rs33950336 [ dbSNP | Ensembl ].		VAR_025177
	Natural variant	30	1	V → A. Corresponds to variant rs2294760 [ dbSNP | Ensembl ].		VAR_031261
	Natural variant	112	1	D → E. Ref.6		VAR_025178
	Natural variant	241	1	V → I. Ref.6 Corresponds to variant rs33920182 [ dbSNP | Ensembl ].		VAR_025179
	Natural variant	349	1	T → S. Ref.6		VAR_025180
	Natural variant	404	1	L → M. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.8 Corresponds to variant rs4895944 [ dbSNP | Ensembl ].		VAR_023530
Experimental info
	Sequence conflict	218	1	D → Y in CAA10569. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 20, 2007. Version 3. Checksum: 14460E1DE5B04870	FASTA	520	58,503
	10 20 30 40 50 60 MVTSSFPISV AVFALITLQV GTQDSFIAAV YEHAVILPNK TETPVSQEDA LNLMNENIDI 70 80 90 100 110 120 LETAIKQAAE QGARIIVTPE DALYGWKFTR ETVFPYLEDI PDPQVNWIPC QDPHRFGHTP 130 140 150 160 170 180 VQARLSCLAK DNSIYVLANL GDKKPCNSRD STCPPNGYFQ YNTNVVYNTE GKLVARYHKY 190 200 210 220 230 240 HLYSEPQFNV PEKPELVTFN TAFGRFGIFT CFDIFFYDPG VTLVKDFHVD TILFPTAWMN 250 260 270 280 290 300 VLPLLTAIEF HSAWAMGMGV NLLVANTHHV SLNMTGSGIY APNGPKVYHY DMKTELGKLL 310 320 330 340 350 360 LSEVDSHPLS SLAYPTAVNW NAYATTIKPF PVQKNTFRGF ISRDGFNFTE LFENAGNLTV 370 380 390 400 410 420 CQKELCCHLS YRMLQKEENE VYVLGAFTGL HGRRRREYWQ VCTLLKCKTT NLTTCGRPVE 430 440 450 460 470 480 TASTRFEMFS LSGTFGTEYV FPEVLLTEIH LSPGKFEVLK DGRLVNKNGS SGPILTVSLF 490 500 510 520 GRWYTKDSLY SSCGTSNSAI TYLLIFILLM IIALQNIVML
	Isoform 2 (GPI-80 variant protein 3) [UniParc]. Checksum: B8314877CAEF51B7	FASTA	299	33,239
	10 20 30 40 50 60 MVTSSFPISV AVFALITLQV GTQDSFIAAV YEHAVILPNK TETPVSQEDA LNLMNENIDI 70 80 90 100 110 120 LETAIKQAAE QGARIIVTPE DALYGWKFTR ETVFPYLEDI PDPQVNWIPC QDPHRFGHTP 130 140 150 160 170 180 VQARLSCLAK DNSIYVLANL GDKKPCNSRD STCPPNGYFQ YNTNVVYNTE GKLVARYHKV 190 200 210 220 230 240 CTLLKCKTTN LTTCGRPVET ASTRFEMFSL SGTFGTEYVF PEVLLTEIHL SPGKFEVLKD 250 260 270 280 290 GRLVNKNGSS GPILTVSLFG RWYTKDSLYS SCGTSNSAIT YLLIFILLMI IALQNIVML
	Isoform 3 (GPI-80 variant protein 2) [UniParc]. Checksum: A961ABF6593C813D	FASTA	192	21,478
	10 20 30 40 50 60 MVTSSFPISV AVFALITLQV GTQDSFIAAV YEHAVILPNK TETPVSQEDA LNLMNENIDI 70 80 90 100 110 120 LETAIKQAAE QGARIIVTPE DALYGWKFTR ETVFPYLEDI PDPQVNWIPC QDPHRFGHTP 130 140 150 160 170 180 VQARLSCLAK DNSIYVLANL GDKKPCNSRD STCPPNGYFQ YNTNVVYNTE GKLVARYHKE 190 TLQSVKRSFA VI
	Isoform 4 (GPI-80 variant protein 1) [UniParc]. Checksum: 0E80EC968942F874	FASTA	195	21,907
	10 20 30 40 50 60 MVTSSFPISV AVFALITLQV GTQDSFIAAV YEHAVILPNK TETPVSQEDA LNLMNENIDI 70 80 90 100 110 120 LETAIKQAAE QGARIIVTPE DALYGWKFTR ETVFPYLEDI PDPQVNWIPC QDPHRFGHTP 130 140 150 160 170 180 VQARLSCLAK DNSIYVLANL GDKKPCNSRD STCPPNGYFQ YNTNVVYNTE GKLVARYHKE 190 VVFMHQMVPK CIIMT
	Isoform 5 (GPI-80 variant protein 4) [UniParc]. Checksum: 0479B5ED49E725DB	FASTA	119	13,247
	10 20 30 40 50 60 MVTSSFPISV AVFALITLQV GTQDSFIAAV YEHAVILPNK TETPVSQEDA LNLMNENIDI 70 80 90 100 110 LETAIKQAAE QGARIIVTPE DALYGWKFTR ETVFPYLEDI PDPQVNWIPC QDPHRSAQC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6." Galland F., Malergue F., Bazin H., Mattei M.-G., Aurrand-Lions M., Theillet C., Naquet P. Genomics 53:203-213(1998) [PubMed: 9790769] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-404. Tissue: Kidney.
[2]	"A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: a possible role for regulation of neutrophil adherence and migration." Suzuki K., Watanabe T., Sakurai S., Ohtake K., Kinoshita T., Araki A., Fujita T., Takei H., Takeda Y., Sato Y., Yamashita T., Araki Y., Sendo F. J. Immunol. 162:4277-4284(1999) [PubMed: 10201959] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-404. Tissue: Peripheral blood.
[3]	"Alternative spliced variants in the pantetheinase family of genes expressed in human neutrophils." Nitto T., Inoue T., Node K. Gene 426:57-64(2008) [PubMed: 18805469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5), VARIANT MET-404. Tissue: Neutrophil.
[4]	"Homo sapiens mRNA for FOAP-4 protein, complete cds." Takayama K., Fujii Y., Tsuritani K., Yajima Y., Amemiya T., Ukai Y., Naito K., Kawaguchi A. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-404. Tissue: Blood.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-404.
[6]	NIEHS SNPs program Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-17; GLU-112; ILE-241; SER-349 AND MET-404.
[7]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-404.
[9]	"Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes." Martin F., Malergue F., Pitari G., Philippe J.M., Philips S., Chabret C., Granjeaud S., Mattei M.G., Mungall A.J., Naquet P., Galland F. Immunogenetics 53:296-306(2001) [PubMed: 11491533] [Abstract] Cited for: FUNCTION.
[10]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-411, MASS SPECTROMETRY. Tissue: Plasma.
[11]	"Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines." Jansen P.A.M., Kamsteeg M., Rodijk-Olthuis D., van Vlijmen-Willems I.M.J.J., de Jongh G.J., Bergers M., Tjabringa G.S., Zeeuwen P.L.J.M., Schalkwijk J. J. Invest. Dermatol. 129:2167-2174(2009) [PubMed: 19322213] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ132100 mRNA. Translation: CAA10569.1. D89974 mRNA. Translation: BAA82525.1. AB435062 mRNA. Translation: BAG30934.1. AB435063 mRNA. Translation: BAG30935.1. AB435064 mRNA. Translation: BAG30936.1. AB435065 mRNA. Translation: BAG30937.1. AB026705 mRNA. Translation: BAB61019.1. AK290908 mRNA. Translation: BAF83597.1. DQ249347 Genomic DNA. Translation: ABB72673.1. AL032821 Genomic DNA. Translation: CAB40076.1. BC126145 mRNA. Translation: AAI26146.1. BC126147 mRNA. Translation: AAI26148.1.
IPI	IPI00030872. IPI00895848. IPI00895868. IPI00954928. IPI00982296.
RefSeq	NP_001229279.1. NM_001242350.1. NP_004656.2. NM_004665.2. NP_511043.1. NM_078488.1.
UniGene	Hs.293130.
3D structure databases
ProteinModelPortal	O95498.
SMR	O95498. Positions 54-307.
ModBase	Search...
Protein-protein interaction databases
STRING	O95498.
PTM databases
PhosphoSite	O95498.
Proteomic databases
PRIDE	O95498.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000326499; ENSP00000322276; ENSG00000112303. ENST00000335846; ENSP00000338251; ENSG00000112303. ENST00000392389; ENSP00000376190; ENSG00000112303. ENST00000418593; ENSP00000387572; ENSG00000112303. ENST00000422400; ENSP00000406536; ENSG00000112303.
GeneID	8875.
KEGG	hsa:8875.
Organism-specific databases
CTD	8875.
GeneCards	GC06M133106.
HGNC	HGNC:12706. VNN2.
MIM	603571. gene.
neXtProt	NX_O95498.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19808.
GeneTree	ENSGT00390000013823.
HOVERGEN	HBG003996.
InParanoid	O95498.
OMA	EYWQVCT.
OrthoDB	EOG4JHCFG.
PhylomeDB	O95498.
Gene expression databases
ArrayExpress	O95498.
Bgee	O95498.
CleanEx	HS_VNN2.
Genevestigator	O95498.
GermOnline	ENSG00000112303. Homo sapiens.
Family and domain databases
InterPro	IPR012101. Biotinidase_euk. IPR003010. Ntlse/CNhydtse. [Graphical view]
Gene3D	G3DSA:3.60.110.10. Ntlse/CNhydtse. 1 hit.
KO	K08069.
PANTHER	PTHR10609. Biotinidase_euk. 1 hit.
Pfam	PF00795. CN_hydrolase. 1 hit. [Graphical view]
PIRSF	PIRSF011861. Biotinidase. 1 hit.
SUPFAM	SSF56317. Ntlse/CNhydtse. 1 hit.
PROSITE	PS50263. CN_HYDROLASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	33319.
SOURCE	Search...

Entry information

Entry name

VNN2_HUMAN

Accession

Primary (citable) accession number: O95498
Secondary accession number(s): A0AUZ3 , A6NDY1, A8K4E3, B2DFZ0, B2DFZ1, B2DFZ2, B2DFZ3, Q2XUN1, Q9UJF3, Q9UMW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	March 20, 2007
Last modified:	January 25, 2012
This is version 102 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.