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O95498 (VNN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vascular non-inflammatory molecule 2

Short name=Vanin-2
EC=3.5.1.92
Alternative name(s):
Glycosylphosphatidyl inositol-anchored protein GPI-80
Protein FOAP-4
Gene names
Name:VNN2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length520 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil. Ref.9

Catalytic activity

(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor Potential.

Tissue specificity

widely expressed with higher expression in spleen and blood. Ref.11

Sequence similarities

Belongs to the CN hydrolase family. BTD/VNN subfamily.

Contains 1 CN hydrolase domain.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   Molecular functionHydrolase
   PTMGPI-anchor
Glycoprotein
Lipoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processcellular component movement

Traceable author statement. Source: ProtInc

pantothenate metabolic process

Inferred from direct assay Ref.9. Source: BHF-UCL

   Cellular componentanchored to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionpantetheine hydrolase activity

Inferred from direct assay Ref.9. Source: BHF-UCL

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O95498-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O95498-2)

Also known as: GPI-80 variant protein 3;

The sequence of this isoform differs from the canonical sequence as follows:
     180-400: Missing.
Isoform 3 (identifier: O95498-3)

Also known as: GPI-80 variant protein 2;

The sequence of this isoform differs from the canonical sequence as follows:
     180-192: YHLYSEPQFNVPE → ETLQSVKRSFAVI
     193-520: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 4 (identifier: O95498-4)

Also known as: GPI-80 variant protein 1;

The sequence of this isoform differs from the canonical sequence as follows:
     180-195: YHLYSEPQFNVPEKPE → EVVFMHQMVPKCIIMT
     196-520: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 5 (identifier: O95498-5)

Also known as: GPI-80 variant protein 4;

The sequence of this isoform differs from the canonical sequence as follows:
     116-119: FGHT → SAQC
     120-520: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 493471Vascular non-inflammatory molecule 2
PRO_0000019718
Propeptide494 – 52027Removed in mature form Potential
PRO_0000019719

Regions

Domain26 – 328303CN hydrolase
Compositional bias393 – 3964Poly-Arg

Amino acid modifications

Lipidation4931GPI-anchor amidated cysteine Potential
Glycosylation391N-linked (GlcNAc...) Potential
Glycosylation2731N-linked (GlcNAc...) Potential
Glycosylation3471N-linked (GlcNAc...) Potential
Glycosylation3571N-linked (GlcNAc...) Potential
Glycosylation4111N-linked (GlcNAc...) Ref.10
Glycosylation4681N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence116 – 1194FGHT → SAQC in isoform 5.
VSP_038554
Alternative sequence120 – 520401Missing in isoform 5.
VSP_038555
Alternative sequence180 – 400221Missing in isoform 2.
VSP_038557
Alternative sequence180 – 19516YHLYS…PEKPE → EVVFMHQMVPKCIIMT in isoform 4.
VSP_038556
Alternative sequence180 – 19213YHLYS…FNVPE → ETLQSVKRSFAVI in isoform 3.
VSP_038558
Alternative sequence193 – 520328Missing in isoform 3.
VSP_038559
Alternative sequence196 – 520325Missing in isoform 4.
VSP_038560
Natural variant171T → N. Ref.6
Corresponds to variant rs33950336 [ dbSNP | Ensembl ].
VAR_025177
Natural variant301V → A.
Corresponds to variant rs2294760 [ dbSNP | Ensembl ].
VAR_031261
Natural variant1121D → E. Ref.6
VAR_025178
Natural variant2411V → I. Ref.6
Corresponds to variant rs33920182 [ dbSNP | Ensembl ].
VAR_025179
Natural variant3491T → S. Ref.6
VAR_025180
Natural variant4041L → M. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.8
Corresponds to variant rs4895944 [ dbSNP | Ensembl ].
VAR_023530

Experimental info

Sequence conflict2181D → Y in CAA10569. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 20, 2007. Version 3.
Checksum: 14460E1DE5B04870

FASTA52058,503
        10         20         30         40         50         60 
MVTSSFPISV AVFALITLQV GTQDSFIAAV YEHAVILPNK TETPVSQEDA LNLMNENIDI 

        70         80         90        100        110        120 
LETAIKQAAE QGARIIVTPE DALYGWKFTR ETVFPYLEDI PDPQVNWIPC QDPHRFGHTP 

       130        140        150        160        170        180 
VQARLSCLAK DNSIYVLANL GDKKPCNSRD STCPPNGYFQ YNTNVVYNTE GKLVARYHKY 

       190        200        210        220        230        240 
HLYSEPQFNV PEKPELVTFN TAFGRFGIFT CFDIFFYDPG VTLVKDFHVD TILFPTAWMN 

       250        260        270        280        290        300 
VLPLLTAIEF HSAWAMGMGV NLLVANTHHV SLNMTGSGIY APNGPKVYHY DMKTELGKLL 

       310        320        330        340        350        360 
LSEVDSHPLS SLAYPTAVNW NAYATTIKPF PVQKNTFRGF ISRDGFNFTE LFENAGNLTV 

       370        380        390        400        410        420 
CQKELCCHLS YRMLQKEENE VYVLGAFTGL HGRRRREYWQ VCTLLKCKTT NLTTCGRPVE 

       430        440        450        460        470        480 
TASTRFEMFS LSGTFGTEYV FPEVLLTEIH LSPGKFEVLK DGRLVNKNGS SGPILTVSLF 

       490        500        510        520 
GRWYTKDSLY SSCGTSNSAI TYLLIFILLM IIALQNIVML 

« Hide

Isoform 2 (GPI-80 variant protein 3) [UniParc].

Checksum: B8314877CAEF51B7
Show »

FASTA29933,239
Isoform 3 (GPI-80 variant protein 2) [UniParc].

Checksum: A961ABF6593C813D
Show »

FASTA19221,478
Isoform 4 (GPI-80 variant protein 1) [UniParc].

Checksum: 0E80EC968942F874
Show »

FASTA19521,907
Isoform 5 (GPI-80 variant protein 4) [UniParc].

Checksum: 0479B5ED49E725DB
Show »

FASTA11913,247

References

« Hide 'large scale' references
[1]"Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6."
Galland F., Malergue F., Bazin H., Mattei M.-G., Aurrand-Lions M., Theillet C., Naquet P.
Genomics 53:203-213(1998) [PubMed: 9790769] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-404.
Tissue: Kidney.
[2]"A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: a possible role for regulation of neutrophil adherence and migration."
Suzuki K., Watanabe T., Sakurai S., Ohtake K., Kinoshita T., Araki A., Fujita T., Takei H., Takeda Y., Sato Y., Yamashita T., Araki Y., Sendo F.
J. Immunol. 162:4277-4284(1999) [PubMed: 10201959] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-404.
Tissue: Peripheral blood.
[3]"Alternative spliced variants in the pantetheinase family of genes expressed in human neutrophils."
Nitto T., Inoue T., Node K.
Gene 426:57-64(2008) [PubMed: 18805469] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5), VARIANT MET-404.
Tissue: Neutrophil.
[4]"Homo sapiens mRNA for FOAP-4 protein, complete cds."
Takayama K., Fujii Y., Tsuritani K., Yajima Y., Amemiya T., Ukai Y., Naito K., Kawaguchi A.
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-404.
Tissue: Blood.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-404.
[6]NIEHS SNPs program
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-17; GLU-112; ILE-241; SER-349 AND MET-404.
[7]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed: 14574404] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-404.
[9]"Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes."
Martin F., Malergue F., Pitari G., Philippe J.M., Philips S., Chabret C., Granjeaud S., Mattei M.G., Mungall A.J., Naquet P., Galland F.
Immunogenetics 53:296-306(2001) [PubMed: 11491533] [Abstract]
Cited for: FUNCTION.
[10]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-411, MASS SPECTROMETRY.
Tissue: Plasma.
[11]"Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines."
Jansen P.A.M., Kamsteeg M., Rodijk-Olthuis D., van Vlijmen-Willems I.M.J.J., de Jongh G.J., Bergers M., Tjabringa G.S., Zeeuwen P.L.J.M., Schalkwijk J.
J. Invest. Dermatol. 129:2167-2174(2009) [PubMed: 19322213] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ132100 mRNA. Translation: CAA10569.1.
D89974 mRNA. Translation: BAA82525.1.
AB435062 mRNA. Translation: BAG30934.1.
AB435063 mRNA. Translation: BAG30935.1.
AB435064 mRNA. Translation: BAG30936.1.
AB435065 mRNA. Translation: BAG30937.1.
AB026705 mRNA. Translation: BAB61019.1.
AK290908 mRNA. Translation: BAF83597.1.
DQ249347 Genomic DNA. Translation: ABB72673.1.
AL032821 Genomic DNA. Translation: CAB40076.1.
BC126145 mRNA. Translation: AAI26146.1.
BC126147 mRNA. Translation: AAI26148.1.
IPIIPI00030872.
IPI00895848.
IPI00895868.
IPI00954928.
IPI00982296.
RefSeqNP_001229279.1. NM_001242350.1.
NP_004656.2. NM_004665.2.
NP_511043.1. NM_078488.1.
UniGeneHs.293130.

3D structure databases

ProteinModelPortalO95498.
SMRO95498. Positions 54-307.
ModBaseSearch...

Protein-protein interaction databases

STRINGO95498.

PTM databases

PhosphoSiteO95498.

Proteomic databases

PRIDEO95498.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000326499; ENSP00000322276; ENSG00000112303.
ENST00000335846; ENSP00000338251; ENSG00000112303.
ENST00000392389; ENSP00000376190; ENSG00000112303.
ENST00000418593; ENSP00000387572; ENSG00000112303.
ENST00000422400; ENSP00000406536; ENSG00000112303.
GeneID8875.
KEGGhsa:8875.

Organism-specific databases

CTD8875.
GeneCardsGC06M133106.
HGNCHGNC:12706. VNN2.
MIM603571. gene.
neXtProtNX_O95498.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG19808.
GeneTreeENSGT00390000013823.
HOVERGENHBG003996.
InParanoidO95498.
OMAEYWQVCT.
OrthoDBEOG4JHCFG.
PhylomeDBO95498.

Gene expression databases

ArrayExpressO95498.
BgeeO95498.
CleanExHS_VNN2.
GenevestigatorO95498.
GermOnlineENSG00000112303. Homo sapiens.

Family and domain databases

InterProIPR012101. Biotinidase_euk.
IPR003010. Ntlse/CNhydtse.
[Graphical view]
Gene3DG3DSA:3.60.110.10. Ntlse/CNhydtse. 1 hit.
KOK08069.
PANTHERPTHR10609. Biotinidase_euk. 1 hit.
PfamPF00795. CN_hydrolase. 1 hit.
[Graphical view]
PIRSFPIRSF011861. Biotinidase. 1 hit.
SUPFAMSSF56317. Ntlse/CNhydtse. 1 hit.
PROSITEPS50263. CN_HYDROLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio33319.
SOURCESearch...

Entry information

Entry nameVNN2_HUMAN
AccessionPrimary (citable) accession number: O95498
Secondary accession number(s): A0AUZ3 expand/collapse secondary AC list , A6NDY1, A8K4E3, B2DFZ0, B2DFZ1, B2DFZ2, B2DFZ3, Q2XUN1, Q9UJF3, Q9UMW2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 20, 2007
Last modified: January 25, 2012
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Human chromosome 6: entries, gene names and cross-references to MIM

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List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families