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Protein

Vascular non-inflammatory molecule 2

Gene

VNN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.1 Publication

Catalytic activityi

(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei80Proton acceptorPROSITE-ProRule annotation1
Active sitei179Proton donorPROSITE-ProRule annotation1
Active sitei211NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

  • pantetheine hydrolase activity Source: BHF-UCL

GO - Biological processi

  • biotin metabolic process Source: GO_Central
  • central nervous system development Source: GO_Central
  • movement of cell or subcellular component Source: ProtInc
  • nitrogen compound metabolic process Source: InterPro
  • pantothenate metabolic process Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112303-MONOMER.
BRENDAi3.5.1.92. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular non-inflammatory molecule 2 (EC:3.5.1.92)
Short name:
Vanin-2
Alternative name(s):
Glycosylphosphatidyl inositol-anchored protein GPI-80
Protein FOAP-4
Gene namesi
Name:VNN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:12706. VNN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8875.
OpenTargetsiENSG00000112303.
PharmGKBiPA37322.

Polymorphism and mutation databases

BioMutaiVNN2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001971823 – 493Vascular non-inflammatory molecule 2Add BLAST471
PropeptideiPRO_0000019719494 – 520Removed in mature formSequence analysisAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...)Sequence analysis1
Glycosylationi273N-linked (GlcNAc...)Sequence analysis1
Glycosylationi347N-linked (GlcNAc...)Sequence analysis1
Glycosylationi357N-linked (GlcNAc...)Sequence analysis1
Glycosylationi411N-linked (GlcNAc...)1 Publication1
Glycosylationi468N-linked (GlcNAc...)Sequence analysis1
Lipidationi493GPI-anchor amidated cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO95498.
PeptideAtlasiO95498.
PRIDEiO95498.

PTM databases

iPTMnetiO95498.
PhosphoSitePlusiO95498.

Expressioni

Tissue specificityi

Widely expressed with higher expression in spleen and blood.1 Publication

Gene expression databases

BgeeiENSG00000112303.
CleanExiHS_VNN2.
ExpressionAtlasiO95498. baseline and differential.
GenevisibleiO95498. HS.

Organism-specific databases

HPAiHPA051229.

Interactioni

Protein-protein interaction databases

BioGridi114394. 39 interactors.
STRINGi9606.ENSP00000322276.

Structurei

3D structure databases

ProteinModelPortaliO95498.
SMRiO95498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 328CN hydrolasePROSITE-ProRule annotationAdd BLAST303

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi393 – 396Poly-Arg4

Sequence similaritiesi

Contains 1 CN hydrolase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0806. Eukaryota.
COG0388. LUCA.
GeneTreeiENSGT00390000013823.
HOVERGENiHBG003996.
InParanoidiO95498.
KOiK08069.
OMAiTNLTTCG.
OrthoDBiEOG091G04QD.
PhylomeDBiO95498.
TreeFamiTF323645.

Family and domain databases

Gene3Di3.60.110.10. 1 hit.
InterProiIPR012101. Biotinidase_euk.
IPR003010. C-N_Hydrolase.
[Graphical view]
PANTHERiPTHR10609. PTHR10609. 1 hit.
PfamiPF00795. CN_hydrolase. 1 hit.
[Graphical view]
PIRSFiPIRSF011861. Biotinidase. 1 hit.
SUPFAMiSSF56317. SSF56317. 1 hit.
PROSITEiPS50263. CN_HYDROLASE. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95498-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVTSSFPISV AVFALITLQV GTQDSFIAAV YEHAVILPNK TETPVSQEDA
60 70 80 90 100
LNLMNENIDI LETAIKQAAE QGARIIVTPE DALYGWKFTR ETVFPYLEDI
110 120 130 140 150
PDPQVNWIPC QDPHRFGHTP VQARLSCLAK DNSIYVLANL GDKKPCNSRD
160 170 180 190 200
STCPPNGYFQ YNTNVVYNTE GKLVARYHKY HLYSEPQFNV PEKPELVTFN
210 220 230 240 250
TAFGRFGIFT CFDIFFYDPG VTLVKDFHVD TILFPTAWMN VLPLLTAIEF
260 270 280 290 300
HSAWAMGMGV NLLVANTHHV SLNMTGSGIY APNGPKVYHY DMKTELGKLL
310 320 330 340 350
LSEVDSHPLS SLAYPTAVNW NAYATTIKPF PVQKNTFRGF ISRDGFNFTE
360 370 380 390 400
LFENAGNLTV CQKELCCHLS YRMLQKEENE VYVLGAFTGL HGRRRREYWQ
410 420 430 440 450
VCTLLKCKTT NLTTCGRPVE TASTRFEMFS LSGTFGTEYV FPEVLLTEIH
460 470 480 490 500
LSPGKFEVLK DGRLVNKNGS SGPILTVSLF GRWYTKDSLY SSCGTSNSAI
510 520
TYLLIFILLM IIALQNIVML
Length:520
Mass (Da):58,503
Last modified:March 20, 2007 - v3
Checksum:i14460E1DE5B04870
GO
Isoform 2 (identifier: O95498-2) [UniParc]FASTAAdd to basket
Also known as: GPI-80 variant protein 3

The sequence of this isoform differs from the canonical sequence as follows:
     180-400: Missing.

Show »
Length:299
Mass (Da):33,239
Checksum:iB8314877CAEF51B7
GO
Isoform 3 (identifier: O95498-3) [UniParc]FASTAAdd to basket
Also known as: GPI-80 variant protein 2

The sequence of this isoform differs from the canonical sequence as follows:
     180-192: YHLYSEPQFNVPE → ETLQSVKRSFAVI
     193-520: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:192
Mass (Da):21,478
Checksum:iA961ABF6593C813D
GO
Isoform 4 (identifier: O95498-4) [UniParc]FASTAAdd to basket
Also known as: GPI-80 variant protein 1

The sequence of this isoform differs from the canonical sequence as follows:
     180-195: YHLYSEPQFNVPEKPE → EVVFMHQMVPKCIIMT
     196-520: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:195
Mass (Da):21,907
Checksum:i0E80EC968942F874
GO
Isoform 5 (identifier: O95498-5) [UniParc]FASTAAdd to basket
Also known as: GPI-80 variant protein 4

The sequence of this isoform differs from the canonical sequence as follows:
     116-119: FGHT → SAQC
     120-520: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:119
Mass (Da):13,247
Checksum:i0479B5ED49E725DB
GO
Isoform 6 (identifier: O95498-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Note: No experimental confirmation available.
Show »
Length:467
Mass (Da):52,844
Checksum:iC47D4720E11BF156
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218D → Y in CAA10569 (PubMed:9790769).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02517717T → N.1 PublicationCorresponds to variant rs33950336dbSNPEnsembl.1
Natural variantiVAR_03126130V → A.Corresponds to variant rs2294760dbSNPEnsembl.1
Natural variantiVAR_025178112D → E.1 PublicationCorresponds to variant rs35993077dbSNPEnsembl.1
Natural variantiVAR_025179241V → I.1 PublicationCorresponds to variant rs33920182dbSNPEnsembl.1
Natural variantiVAR_025180349T → S.1 PublicationCorresponds to variant rs36092168dbSNPEnsembl.1
Natural variantiVAR_023530404L → M.7 PublicationsCorresponds to variant rs4895944dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0449121 – 53Missing in isoform 6. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_038554116 – 119FGHT → SAQC in isoform 5. 1 Publication4
Alternative sequenceiVSP_038555120 – 520Missing in isoform 5. 1 PublicationAdd BLAST401
Alternative sequenceiVSP_038557180 – 400Missing in isoform 2. 1 PublicationAdd BLAST221
Alternative sequenceiVSP_038556180 – 195YHLYS…PEKPE → EVVFMHQMVPKCIIMT in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_038558180 – 192YHLYS…FNVPE → ETLQSVKRSFAVI in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_038559193 – 520Missing in isoform 3. 1 PublicationAdd BLAST328
Alternative sequenceiVSP_038560196 – 520Missing in isoform 4. 1 PublicationAdd BLAST325

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132100 mRNA. Translation: CAA10569.1.
D89974 mRNA. Translation: BAA82525.1.
AB435062 mRNA. Translation: BAG30934.1.
AB435063 mRNA. Translation: BAG30935.1.
AB435064 mRNA. Translation: BAG30936.1.
AB435065 mRNA. Translation: BAG30937.1.
AB026705 mRNA. Translation: BAB61019.1.
AK290908 mRNA. Translation: BAF83597.1.
AK292125 mRNA. Translation: BAF84814.1.
DQ249347 Genomic DNA. Translation: ABB72673.1.
AL032821 Genomic DNA. Translation: CAB40076.1.
CH471051 Genomic DNA. Translation: EAW48016.1.
BC126145 mRNA. Translation: AAI26146.1.
BC126147 mRNA. Translation: AAI26148.1.
CCDSiCCDS5161.1. [O95498-1]
CCDS5162.1. [O95498-6]
CCDS56451.1. [O95498-2]
RefSeqiNP_001229279.1. NM_001242350.2.
NP_004656.2. NM_004665.4.
NP_511043.1. NM_078488.2.
XP_006715656.1. XM_006715593.3. [O95498-6]
XP_016866896.1. XM_017011407.1. [O95498-1]
UniGeneiHs.293130.

Genome annotation databases

EnsembliENST00000326499; ENSP00000322276; ENSG00000112303. [O95498-1]
ENST00000525270; ENSP00000436822; ENSG00000112303. [O95498-6]
ENST00000525289; ENSP00000436935; ENSG00000112303. [O95498-2]
ENST00000525674; ENSP00000436863; ENSG00000112303. [O95498-4]
ENST00000532053; ENSP00000434077; ENSG00000112303. [O95498-3]
GeneIDi8875.
KEGGihsa:8875.
UCSCiuc003qdt.4. human. [O95498-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132100 mRNA. Translation: CAA10569.1.
D89974 mRNA. Translation: BAA82525.1.
AB435062 mRNA. Translation: BAG30934.1.
AB435063 mRNA. Translation: BAG30935.1.
AB435064 mRNA. Translation: BAG30936.1.
AB435065 mRNA. Translation: BAG30937.1.
AB026705 mRNA. Translation: BAB61019.1.
AK290908 mRNA. Translation: BAF83597.1.
AK292125 mRNA. Translation: BAF84814.1.
DQ249347 Genomic DNA. Translation: ABB72673.1.
AL032821 Genomic DNA. Translation: CAB40076.1.
CH471051 Genomic DNA. Translation: EAW48016.1.
BC126145 mRNA. Translation: AAI26146.1.
BC126147 mRNA. Translation: AAI26148.1.
CCDSiCCDS5161.1. [O95498-1]
CCDS5162.1. [O95498-6]
CCDS56451.1. [O95498-2]
RefSeqiNP_001229279.1. NM_001242350.2.
NP_004656.2. NM_004665.4.
NP_511043.1. NM_078488.2.
XP_006715656.1. XM_006715593.3. [O95498-6]
XP_016866896.1. XM_017011407.1. [O95498-1]
UniGeneiHs.293130.

3D structure databases

ProteinModelPortaliO95498.
SMRiO95498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114394. 39 interactors.
STRINGi9606.ENSP00000322276.

PTM databases

iPTMnetiO95498.
PhosphoSitePlusiO95498.

Polymorphism and mutation databases

BioMutaiVNN2.

Proteomic databases

PaxDbiO95498.
PeptideAtlasiO95498.
PRIDEiO95498.

Protocols and materials databases

DNASUi8875.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326499; ENSP00000322276; ENSG00000112303. [O95498-1]
ENST00000525270; ENSP00000436822; ENSG00000112303. [O95498-6]
ENST00000525289; ENSP00000436935; ENSG00000112303. [O95498-2]
ENST00000525674; ENSP00000436863; ENSG00000112303. [O95498-4]
ENST00000532053; ENSP00000434077; ENSG00000112303. [O95498-3]
GeneIDi8875.
KEGGihsa:8875.
UCSCiuc003qdt.4. human. [O95498-1]

Organism-specific databases

CTDi8875.
DisGeNETi8875.
GeneCardsiVNN2.
HGNCiHGNC:12706. VNN2.
HPAiHPA051229.
MIMi603571. gene.
neXtProtiNX_O95498.
OpenTargetsiENSG00000112303.
PharmGKBiPA37322.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0806. Eukaryota.
COG0388. LUCA.
GeneTreeiENSGT00390000013823.
HOVERGENiHBG003996.
InParanoidiO95498.
KOiK08069.
OMAiTNLTTCG.
OrthoDBiEOG091G04QD.
PhylomeDBiO95498.
TreeFamiTF323645.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112303-MONOMER.
BRENDAi3.5.1.92. 2681.

Miscellaneous databases

GeneWikiiVNN2.
GenomeRNAii8875.
PROiO95498.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112303.
CleanExiHS_VNN2.
ExpressionAtlasiO95498. baseline and differential.
GenevisibleiO95498. HS.

Family and domain databases

Gene3Di3.60.110.10. 1 hit.
InterProiIPR012101. Biotinidase_euk.
IPR003010. C-N_Hydrolase.
[Graphical view]
PANTHERiPTHR10609. PTHR10609. 1 hit.
PfamiPF00795. CN_hydrolase. 1 hit.
[Graphical view]
PIRSFiPIRSF011861. Biotinidase. 1 hit.
SUPFAMiSSF56317. SSF56317. 1 hit.
PROSITEiPS50263. CN_HYDROLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVNN2_HUMAN
AccessioniPrimary (citable) accession number: O95498
Secondary accession number(s): A0AUZ3
, A6NDY1, A8K4E3, A8K7W0, B2DFZ0, B2DFZ1, B2DFZ2, B2DFZ3, F6XL73, Q2XUN1, Q9UJF3, Q9UMW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 20, 2007
Last modified: November 2, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.