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Protein

Vascular non-inflammatory molecule 2

Gene

VNN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.1 Publication

Catalytic activityi

(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei80 – 801Proton acceptorPROSITE-ProRule annotation
Active sitei179 – 1791Proton donorPROSITE-ProRule annotation
Active sitei211 – 2111NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

  • pantetheine hydrolase activity Source: BHF-UCL

GO - Biological processi

  • biotin metabolic process Source: GO_Central
  • central nervous system development Source: GO_Central
  • movement of cell or subcellular component Source: ProtInc
  • pantothenate metabolic process Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BRENDAi3.5.1.92. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular non-inflammatory molecule 2 (EC:3.5.1.92)
Short name:
Vanin-2
Alternative name(s):
Glycosylphosphatidyl inositol-anchored protein GPI-80
Protein FOAP-4
Gene namesi
Name:VNN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:12706. VNN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37322.

Polymorphism and mutation databases

BioMutaiVNN2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 493471Vascular non-inflammatory molecule 2PRO_0000019718Add
BLAST
Propeptidei494 – 52027Removed in mature formSequence analysisPRO_0000019719Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence analysis
Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence analysis
Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence analysis
Glycosylationi357 – 3571N-linked (GlcNAc...)Sequence analysis
Glycosylationi411 – 4111N-linked (GlcNAc...)1 Publication
Glycosylationi468 – 4681N-linked (GlcNAc...)Sequence analysis
Lipidationi493 – 4931GPI-anchor amidated cysteineSequence analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO95498.
PeptideAtlasiO95498.
PRIDEiO95498.

PTM databases

iPTMnetiO95498.
PhosphoSiteiO95498.

Expressioni

Tissue specificityi

Widely expressed with higher expression in spleen and blood.1 Publication

Gene expression databases

BgeeiO95498.
CleanExiHS_VNN2.
ExpressionAtlasiO95498. baseline and differential.
GenevisibleiO95498. HS.

Organism-specific databases

HPAiHPA051229.

Interactioni

Protein-protein interaction databases

BioGridi114394. 39 interactions.
STRINGi9606.ENSP00000322276.

Structurei

3D structure databases

ProteinModelPortaliO95498.
SMRiO95498. Positions 23-487.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 328303CN hydrolasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi393 – 3964Poly-Arg

Sequence similaritiesi

Contains 1 CN hydrolase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0806. Eukaryota.
COG0388. LUCA.
GeneTreeiENSGT00390000013823.
HOVERGENiHBG003996.
InParanoidiO95498.
KOiK08069.
OMAiTNLTTCG.
PhylomeDBiO95498.
TreeFamiTF323645.

Family and domain databases

Gene3Di3.60.110.10. 1 hit.
InterProiIPR012101. Biotinidase_euk.
IPR003010. C-N_Hydrolase.
[Graphical view]
PANTHERiPTHR10609. PTHR10609. 1 hit.
PfamiPF00795. CN_hydrolase. 1 hit.
[Graphical view]
PIRSFiPIRSF011861. Biotinidase. 1 hit.
SUPFAMiSSF56317. SSF56317. 1 hit.
PROSITEiPS50263. CN_HYDROLASE. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95498-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVTSSFPISV AVFALITLQV GTQDSFIAAV YEHAVILPNK TETPVSQEDA
60 70 80 90 100
LNLMNENIDI LETAIKQAAE QGARIIVTPE DALYGWKFTR ETVFPYLEDI
110 120 130 140 150
PDPQVNWIPC QDPHRFGHTP VQARLSCLAK DNSIYVLANL GDKKPCNSRD
160 170 180 190 200
STCPPNGYFQ YNTNVVYNTE GKLVARYHKY HLYSEPQFNV PEKPELVTFN
210 220 230 240 250
TAFGRFGIFT CFDIFFYDPG VTLVKDFHVD TILFPTAWMN VLPLLTAIEF
260 270 280 290 300
HSAWAMGMGV NLLVANTHHV SLNMTGSGIY APNGPKVYHY DMKTELGKLL
310 320 330 340 350
LSEVDSHPLS SLAYPTAVNW NAYATTIKPF PVQKNTFRGF ISRDGFNFTE
360 370 380 390 400
LFENAGNLTV CQKELCCHLS YRMLQKEENE VYVLGAFTGL HGRRRREYWQ
410 420 430 440 450
VCTLLKCKTT NLTTCGRPVE TASTRFEMFS LSGTFGTEYV FPEVLLTEIH
460 470 480 490 500
LSPGKFEVLK DGRLVNKNGS SGPILTVSLF GRWYTKDSLY SSCGTSNSAI
510 520
TYLLIFILLM IIALQNIVML
Length:520
Mass (Da):58,503
Last modified:March 20, 2007 - v3
Checksum:i14460E1DE5B04870
GO
Isoform 2 (identifier: O95498-2) [UniParc]FASTAAdd to basket

Also known as: GPI-80 variant protein 3

The sequence of this isoform differs from the canonical sequence as follows:
     180-400: Missing.

Show »
Length:299
Mass (Da):33,239
Checksum:iB8314877CAEF51B7
GO
Isoform 3 (identifier: O95498-3) [UniParc]FASTAAdd to basket

Also known as: GPI-80 variant protein 2

The sequence of this isoform differs from the canonical sequence as follows:
     180-192: YHLYSEPQFNVPE → ETLQSVKRSFAVI
     193-520: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:192
Mass (Da):21,478
Checksum:iA961ABF6593C813D
GO
Isoform 4 (identifier: O95498-4) [UniParc]FASTAAdd to basket

Also known as: GPI-80 variant protein 1

The sequence of this isoform differs from the canonical sequence as follows:
     180-195: YHLYSEPQFNVPEKPE → EVVFMHQMVPKCIIMT
     196-520: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:195
Mass (Da):21,907
Checksum:i0E80EC968942F874
GO
Isoform 5 (identifier: O95498-5) [UniParc]FASTAAdd to basket

Also known as: GPI-80 variant protein 4

The sequence of this isoform differs from the canonical sequence as follows:
     116-119: FGHT → SAQC
     120-520: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:119
Mass (Da):13,247
Checksum:i0479B5ED49E725DB
GO
Isoform 6 (identifier: O95498-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Note: No experimental confirmation available.
Show »
Length:467
Mass (Da):52,844
Checksum:iC47D4720E11BF156
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti218 – 2181D → Y in CAA10569 (PubMed:9790769).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171T → N.1 Publication
Corresponds to variant rs33950336 [ dbSNP | Ensembl ].
VAR_025177
Natural varianti30 – 301V → A.
Corresponds to variant rs2294760 [ dbSNP | Ensembl ].
VAR_031261
Natural varianti112 – 1121D → E.1 Publication
Corresponds to variant rs35993077 [ dbSNP | Ensembl ].
VAR_025178
Natural varianti241 – 2411V → I.1 Publication
Corresponds to variant rs33920182 [ dbSNP | Ensembl ].
VAR_025179
Natural varianti349 – 3491T → S.1 Publication
Corresponds to variant rs36092168 [ dbSNP | Ensembl ].
VAR_025180
Natural varianti404 – 4041L → M.7 Publications
Corresponds to variant rs4895944 [ dbSNP | Ensembl ].
VAR_023530

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5353Missing in isoform 6. 1 PublicationVSP_044912Add
BLAST
Alternative sequencei116 – 1194FGHT → SAQC in isoform 5. 1 PublicationVSP_038554
Alternative sequencei120 – 520401Missing in isoform 5. 1 PublicationVSP_038555Add
BLAST
Alternative sequencei180 – 400221Missing in isoform 2. 1 PublicationVSP_038557Add
BLAST
Alternative sequencei180 – 19516YHLYS…PEKPE → EVVFMHQMVPKCIIMT in isoform 4. 1 PublicationVSP_038556Add
BLAST
Alternative sequencei180 – 19213YHLYS…FNVPE → ETLQSVKRSFAVI in isoform 3. 1 PublicationVSP_038558Add
BLAST
Alternative sequencei193 – 520328Missing in isoform 3. 1 PublicationVSP_038559Add
BLAST
Alternative sequencei196 – 520325Missing in isoform 4. 1 PublicationVSP_038560Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132100 mRNA. Translation: CAA10569.1.
D89974 mRNA. Translation: BAA82525.1.
AB435062 mRNA. Translation: BAG30934.1.
AB435063 mRNA. Translation: BAG30935.1.
AB435064 mRNA. Translation: BAG30936.1.
AB435065 mRNA. Translation: BAG30937.1.
AB026705 mRNA. Translation: BAB61019.1.
AK290908 mRNA. Translation: BAF83597.1.
AK292125 mRNA. Translation: BAF84814.1.
DQ249347 Genomic DNA. Translation: ABB72673.1.
AL032821 Genomic DNA. Translation: CAB40076.1.
CH471051 Genomic DNA. Translation: EAW48016.1.
BC126145 mRNA. Translation: AAI26146.1.
BC126147 mRNA. Translation: AAI26148.1.
CCDSiCCDS5161.1. [O95498-1]
CCDS5162.1. [O95498-6]
CCDS56451.1. [O95498-2]
RefSeqiNP_001229279.1. NM_001242350.2.
NP_004656.2. NM_004665.4.
NP_511043.1. NM_078488.2.
XP_006715656.1. XM_006715593.2. [O95498-6]
UniGeneiHs.293130.

Genome annotation databases

EnsembliENST00000326499; ENSP00000322276; ENSG00000112303. [O95498-1]
ENST00000525270; ENSP00000436822; ENSG00000112303. [O95498-6]
ENST00000525289; ENSP00000436935; ENSG00000112303. [O95498-2]
ENST00000525674; ENSP00000436863; ENSG00000112303. [O95498-4]
ENST00000532053; ENSP00000434077; ENSG00000112303. [O95498-3]
GeneIDi8875.
KEGGihsa:8875.
UCSCiuc003qdt.4. human. [O95498-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132100 mRNA. Translation: CAA10569.1.
D89974 mRNA. Translation: BAA82525.1.
AB435062 mRNA. Translation: BAG30934.1.
AB435063 mRNA. Translation: BAG30935.1.
AB435064 mRNA. Translation: BAG30936.1.
AB435065 mRNA. Translation: BAG30937.1.
AB026705 mRNA. Translation: BAB61019.1.
AK290908 mRNA. Translation: BAF83597.1.
AK292125 mRNA. Translation: BAF84814.1.
DQ249347 Genomic DNA. Translation: ABB72673.1.
AL032821 Genomic DNA. Translation: CAB40076.1.
CH471051 Genomic DNA. Translation: EAW48016.1.
BC126145 mRNA. Translation: AAI26146.1.
BC126147 mRNA. Translation: AAI26148.1.
CCDSiCCDS5161.1. [O95498-1]
CCDS5162.1. [O95498-6]
CCDS56451.1. [O95498-2]
RefSeqiNP_001229279.1. NM_001242350.2.
NP_004656.2. NM_004665.4.
NP_511043.1. NM_078488.2.
XP_006715656.1. XM_006715593.2. [O95498-6]
UniGeneiHs.293130.

3D structure databases

ProteinModelPortaliO95498.
SMRiO95498. Positions 23-487.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114394. 39 interactions.
STRINGi9606.ENSP00000322276.

PTM databases

iPTMnetiO95498.
PhosphoSiteiO95498.

Polymorphism and mutation databases

BioMutaiVNN2.

Proteomic databases

PaxDbiO95498.
PeptideAtlasiO95498.
PRIDEiO95498.

Protocols and materials databases

DNASUi8875.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326499; ENSP00000322276; ENSG00000112303. [O95498-1]
ENST00000525270; ENSP00000436822; ENSG00000112303. [O95498-6]
ENST00000525289; ENSP00000436935; ENSG00000112303. [O95498-2]
ENST00000525674; ENSP00000436863; ENSG00000112303. [O95498-4]
ENST00000532053; ENSP00000434077; ENSG00000112303. [O95498-3]
GeneIDi8875.
KEGGihsa:8875.
UCSCiuc003qdt.4. human. [O95498-1]

Organism-specific databases

CTDi8875.
GeneCardsiVNN2.
HGNCiHGNC:12706. VNN2.
HPAiHPA051229.
MIMi603571. gene.
neXtProtiNX_O95498.
PharmGKBiPA37322.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0806. Eukaryota.
COG0388. LUCA.
GeneTreeiENSGT00390000013823.
HOVERGENiHBG003996.
InParanoidiO95498.
KOiK08069.
OMAiTNLTTCG.
PhylomeDBiO95498.
TreeFamiTF323645.

Enzyme and pathway databases

BRENDAi3.5.1.92. 2681.

Miscellaneous databases

GeneWikiiVNN2.
GenomeRNAii8875.
PROiO95498.
SOURCEiSearch...

Gene expression databases

BgeeiO95498.
CleanExiHS_VNN2.
ExpressionAtlasiO95498. baseline and differential.
GenevisibleiO95498. HS.

Family and domain databases

Gene3Di3.60.110.10. 1 hit.
InterProiIPR012101. Biotinidase_euk.
IPR003010. C-N_Hydrolase.
[Graphical view]
PANTHERiPTHR10609. PTHR10609. 1 hit.
PfamiPF00795. CN_hydrolase. 1 hit.
[Graphical view]
PIRSFiPIRSF011861. Biotinidase. 1 hit.
SUPFAMiSSF56317. SSF56317. 1 hit.
PROSITEiPS50263. CN_HYDROLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6."
    Galland F., Malergue F., Bazin H., Mattei M.-G., Aurrand-Lions M., Theillet C., Naquet P.
    Genomics 53:203-213(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-404.
    Tissue: Kidney.
  2. "A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: a possible role for regulation of neutrophil adherence and migration."
    Suzuki K., Watanabe T., Sakurai S., Ohtake K., Kinoshita T., Araki A., Fujita T., Takei H., Takeda Y., Sato Y., Yamashita T., Araki Y., Sendo F.
    J. Immunol. 162:4277-4284(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-404.
    Tissue: Peripheral blood.
  3. "Alternative spliced variants in the pantetheinase family of genes expressed in human neutrophils."
    Nitto T., Inoue T., Node K.
    Gene 426:57-64(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5), VARIANT MET-404.
    Tissue: Neutrophil.
  4. "Homo sapiens mRNA for FOAP-4 protein, complete cds."
    Takayama K., Fujii Y., Tsuritani K., Yajima Y., Amemiya T., Ukai Y., Naito K., Kawaguchi A.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-404.
    Tissue: Blood.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6), VARIANT MET-404.
    Tissue: Synovium.
  6. NIEHS SNPs program
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-17; GLU-112; ILE-241; SER-349 AND MET-404.
  7. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-404.
  10. "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes."
    Martin F., Malergue F., Pitari G., Philippe J.M., Philips S., Chabret C., Granjeaud S., Mattei M.G., Mungall A.J., Naquet P., Galland F.
    Immunogenetics 53:296-306(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-411.
    Tissue: Plasma.
  12. "Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines."
    Jansen P.A.M., Kamsteeg M., Rodijk-Olthuis D., van Vlijmen-Willems I.M.J.J., de Jongh G.J., Bergers M., Tjabringa G.S., Zeeuwen P.L.J.M., Schalkwijk J.
    J. Invest. Dermatol. 129:2167-2174(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiVNN2_HUMAN
AccessioniPrimary (citable) accession number: O95498
Secondary accession number(s): A0AUZ3
, A6NDY1, A8K4E3, A8K7W0, B2DFZ0, B2DFZ1, B2DFZ2, B2DFZ3, F6XL73, Q2XUN1, Q9UJF3, Q9UMW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 20, 2007
Last modified: July 6, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.