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O95497

- VNN1_HUMAN

UniProt

O95497 - VNN1_HUMAN

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Protein
Pantetheinase
Gene
VNN1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.2 Publications

Catalytic activityi

(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791Proton acceptor By similarity
Active sitei178 – 1781Proton donor By similarity
Active sitei211 – 2111Nucleophile By similarity

GO - Molecular functioni

  1. GPI anchor binding Source: BHF-UCL
  2. pantetheine hydrolase activity Source: BHF-UCL
Complete GO annotation...

GO - Biological processi

  1. acute inflammatory response Source: BHF-UCL
  2. cellular component movement Source: ProtInc
  3. chronic inflammatory response Source: BHF-UCL
  4. inflammatory response Source: BHF-UCL
  5. innate immune response Source: BHF-UCL
  6. negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress Source: BHF-UCL
  7. pantothenate metabolic process Source: BHF-UCL
  8. positive regulation of T cell differentiation in thymus Source: BHF-UCL
  9. response to oxidative stress Source: BHF-UCL
  10. single organismal cell-cell adhesion Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Pantetheinase (EC:3.5.1.92)
Alternative name(s):
Pantetheine hydrolase
Tiff66
Vascular non-inflammatory molecule 1
Short name:
Vanin-1
Gene namesi
Name:VNN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:12705. VNN1.

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor Reviewed prediction

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of membrane Source: BHF-UCL
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37321.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 491470Pantetheinase
PRO_0000019712Add
BLAST
Propeptidei492 – 51322Removed in mature form Reviewed prediction
PRO_0000019713Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)1 Publication
Glycosylationi130 – 1301N-linked (GlcNAc...)1 Publication
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi283 – 2831N-linked (GlcNAc...)1 Publication
Glycosylationi315 – 3151N-linked (GlcNAc...)1 Publication
Glycosylationi353 – 3531N-linked (GlcNAc...)3 Publications
Lipidationi491 – 4911GPI-anchor amidated glycine Reviewed prediction

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO95497.
PeptideAtlasiO95497.
PRIDEiO95497.

PTM databases

PhosphoSiteiO95497.

Expressioni

Tissue specificityi

Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin.1 Publication

Inductioni

By Th17/Th1 type cytokines, but not by Th2-type.1 Publication

Gene expression databases

BgeeiO95497.
CleanExiHS_VNN1.
GenevestigatoriO95497.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000356905.

Structurei

3D structure databases

ProteinModelPortaliO95497.
SMRiO95497. Positions 54-241.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 328304CN hydrolase
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0388.
HOVERGENiHBG003996.
InParanoidiO95497.
KOiK08069.
OMAiRYYLQIC.
OrthoDBiEOG7HF1J0.
PhylomeDBiO95497.
TreeFamiTF323645.

Family and domain databases

Gene3Di3.60.110.10. 1 hit.
InterProiIPR012101. Biotinidase_euk.
IPR003010. C-N_Hydrolase.
[Graphical view]
PANTHERiPTHR10609. PTHR10609. 1 hit.
PfamiPF00795. CN_hydrolase. 1 hit.
[Graphical view]
PIRSFiPIRSF011861. Biotinidase. 1 hit.
SUPFAMiSSF56317. SSF56317. 1 hit.
PROSITEiPS50263. CN_HYDROLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95497-1 [UniParc]FASTAAdd to Basket

« Hide

MTTQLPAYVA ILLFYVSRAS CQDTFTAAVY EHAAILPNAT LTPVSREEAL    50
ALMNRNLDIL EGAITSAADQ GAHIIVTPED AIYGWNFNRD SLYPYLEDIP 100
DPEVNWIPCN NRNRFGQTPV QERLSCLAKN NSIYVVANIG DKKPCDTSDP 150
QCPPDGRYQY NTDVVFDSQG KLVARYHKQN LFMGENQFNV PKEPEIVTFN 200
TTFGSFGIFT CFDILFHDPA VTLVKDFHVD TIVFPTAWMN VLPHLSAVEF 250
HSAWAMGMRV NFLASNIHYP SKKMTGSGIY APNSSRAFHY DMKTEEGKLL 300
LSQLDSHPSH SAVVNWTSYA SSIEALSSGN KEFKGTVFFD EFTFVKLTGV 350
AGNYTVCQKD LCCHLSYKMS ENIPNEVYAL GAFDGLHTVE GRYYLQICTL 400
LKCKTTNLNT CGDSAETAST RFEMFSLSGT FGTQYVFPEV LLSENQLAPG 450
EFQVSTDGRL FSLKPTSGPV LTVTLFGRLY EKDWASNASS GLTAQARIIM 500
LIVIAPIVCS LSW 513
Length:513
Mass (Da):57,012
Last modified:September 27, 2005 - v2
Checksum:i018D2417C12E403F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261T → I.4 Publications
Corresponds to variant rs2294757 [ dbSNP | Ensembl ].
VAR_023529
Natural varianti63 – 631A → T.1 Publication
VAR_023967
Natural varianti131 – 1311N → S.2 Publications
Corresponds to variant rs2272996 [ dbSNP | Ensembl ].
VAR_023968
Natural varianti136 – 1361V → L.1 Publication
Corresponds to variant rs45610032 [ dbSNP | Ensembl ].
VAR_023969
Natural varianti146 – 1461D → N.1 Publication
Corresponds to variant rs45624336 [ dbSNP | Ensembl ].
VAR_023970
Natural varianti296 – 2961E → D.1 Publication
Corresponds to variant rs45523444 [ dbSNP | Ensembl ].
VAR_023971
Natural varianti325 – 3251A → E.1 Publication
Corresponds to variant rs34535050 [ dbSNP | Ensembl ].
VAR_023972
Natural varianti336 – 3361T → A.1 Publication
Corresponds to variant rs45562238 [ dbSNP | Ensembl ].
VAR_023973
Natural varianti373 – 3731I → T.1 Publication
Corresponds to variant rs35938565 [ dbSNP | Ensembl ].
VAR_023974

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti101 – 1011D → N in AAH96268. 1 Publication
Sequence conflicti113 – 1131N → I in AAY88742. 1 Publication
Sequence conflicti423 – 4231E → D in AAF21453. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ132099 mRNA. Translation: CAA10568.1.
U39664 mRNA. Translation: AAF21453.1.
AK290425 mRNA. Translation: BAF83114.1.
DQ100297 Genomic DNA. Translation: AAY88742.1.
AL032821 Genomic DNA. Translation: CAB40075.1.
BC096265 mRNA. Translation: AAH96265.1.
BC096266 mRNA. Translation: AAH96266.1.
BC096267 mRNA. Translation: AAH96267.1.
BC096268 mRNA. Translation: AAH96268.1.
CCDSiCCDS5159.1.
RefSeqiNP_004657.2. NM_004666.2.
UniGeneiHs.12114.
Hs.720659.

Genome annotation databases

EnsembliENST00000367928; ENSP00000356905; ENSG00000112299.
GeneIDi8876.
KEGGihsa:8876.
UCSCiuc003qdo.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ132099 mRNA. Translation: CAA10568.1 .
U39664 mRNA. Translation: AAF21453.1 .
AK290425 mRNA. Translation: BAF83114.1 .
DQ100297 Genomic DNA. Translation: AAY88742.1 .
AL032821 Genomic DNA. Translation: CAB40075.1 .
BC096265 mRNA. Translation: AAH96265.1 .
BC096266 mRNA. Translation: AAH96266.1 .
BC096267 mRNA. Translation: AAH96267.1 .
BC096268 mRNA. Translation: AAH96268.1 .
CCDSi CCDS5159.1.
RefSeqi NP_004657.2. NM_004666.2.
UniGenei Hs.12114.
Hs.720659.

3D structure databases

ProteinModelPortali O95497.
SMRi O95497. Positions 54-241.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000356905.

PTM databases

PhosphoSitei O95497.

Proteomic databases

PaxDbi O95497.
PeptideAtlasi O95497.
PRIDEi O95497.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367928 ; ENSP00000356905 ; ENSG00000112299 .
GeneIDi 8876.
KEGGi hsa:8876.
UCSCi uc003qdo.3. human.

Organism-specific databases

CTDi 8876.
GeneCardsi GC06M133001.
H-InvDBi HIX0022602.
HGNCi HGNC:12705. VNN1.
MIMi 603570. gene.
neXtProti NX_O95497.
PharmGKBi PA37321.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0388.
HOVERGENi HBG003996.
InParanoidi O95497.
KOi K08069.
OMAi RYYLQIC.
OrthoDBi EOG7HF1J0.
PhylomeDBi O95497.
TreeFami TF323645.

Miscellaneous databases

GeneWikii VNN1.
GenomeRNAii 8876.
NextBioi 33325.
PROi O95497.
SOURCEi Search...

Gene expression databases

Bgeei O95497.
CleanExi HS_VNN1.
Genevestigatori O95497.

Family and domain databases

Gene3Di 3.60.110.10. 1 hit.
InterProi IPR012101. Biotinidase_euk.
IPR003010. C-N_Hydrolase.
[Graphical view ]
PANTHERi PTHR10609. PTHR10609. 1 hit.
Pfami PF00795. CN_hydrolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF011861. Biotinidase. 1 hit.
SUPFAMi SSF56317. SSF56317. 1 hit.
PROSITEi PS50263. CN_HYDROLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6."
    Galland F., Malergue F., Bazin H., Mattei M.-G., Aurrand-Lions M., Theillet C., Naquet P.
    Genomics 53:203-213(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-26.
    Tissue: Liver.
  2. "Human Tiff66."
    Prehn S., Friedrichson T., Henske A., Boehm S., Hartmann E., Kurzchalia T.V.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-26.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-26.
    Tissue: Umbilical cord blood.
  4. NIEHS SNPs program
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-26; THR-63; SER-131; LEU-136; ASN-146; ASP-296; GLU-325; ALA-336 AND THR-373.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-131.
  7. "Is pantetheinase the actual identity of mouse and human vanin-1 proteins?"
    Maras B., Barra D., Dupre S., Pitari G.
    FEBS Lett. 461:149-152(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes."
    Martin F., Malergue F., Pitari G., Philippe J.M., Philips S., Chabret C., Granjeaud S., Mattei M.G., Mungall A.J., Naquet P., Galland F.
    Immunogenetics 53:296-306(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-38 AND ASN-353.
    Tissue: Bile.
  10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-130; ASN-283; ASN-315 AND ASN-353.
    Tissue: Plasma.
  11. "Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines."
    Jansen P.A.M., Kamsteeg M., Rodijk-Olthuis D., van Vlijmen-Willems I.M.J.J., de Jongh G.J., Bergers M., Tjabringa G.S., Zeeuwen P.L.J.M., Schalkwijk J.
    J. Invest. Dermatol. 129:2167-2174(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION BY CYTOKINES.
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-353.
    Tissue: Liver.

Entry informationi

Entry nameiVNN1_HUMAN
AccessioniPrimary (citable) accession number: O95497
Secondary accession number(s): A8K310
, Q4JFW6, Q4VAS7, Q4VAS8, Q4VAS9, Q9UF16, Q9UJF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: September 27, 2005
Last modified: September 3, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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