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O95497

- VNN1_HUMAN

UniProt

O95497 - VNN1_HUMAN

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Protein

Pantetheinase

Gene

VNN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.2 Publications

Catalytic activityi

(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791Proton acceptorPROSITE-ProRule annotation
Active sitei178 – 1781Proton donorPROSITE-ProRule annotation
Active sitei211 – 2111NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

  1. GPI anchor binding Source: BHF-UCL
  2. pantetheine hydrolase activity Source: BHF-UCL

GO - Biological processi

  1. acute inflammatory response Source: BHF-UCL
  2. cellular component movement Source: ProtInc
  3. chronic inflammatory response Source: BHF-UCL
  4. inflammatory response Source: BHF-UCL
  5. innate immune response Source: BHF-UCL
  6. negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: BHF-UCL
  7. pantothenate metabolic process Source: BHF-UCL
  8. positive regulation of T cell differentiation in thymus Source: BHF-UCL
  9. response to oxidative stress Source: BHF-UCL
  10. single organismal cell-cell adhesion Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Pantetheinase (EC:3.5.1.92)
Alternative name(s):
Pantetheine hydrolase
Tiff66
Vascular non-inflammatory molecule 1
Short name:
Vanin-1
Gene namesi
Name:VNN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:12705. VNN1.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of membrane Source: BHF-UCL
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37321.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 491470PantetheinasePRO_0000019712Add
BLAST
Propeptidei492 – 51322Removed in mature formSequence AnalysisPRO_0000019713Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)1 Publication
Glycosylationi130 – 1301N-linked (GlcNAc...)1 Publication
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi283 – 2831N-linked (GlcNAc...)1 Publication
Glycosylationi315 – 3151N-linked (GlcNAc...)1 Publication
Glycosylationi353 – 3531N-linked (GlcNAc...)3 Publications
Lipidationi491 – 4911GPI-anchor amidated glycineSequence Analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO95497.
PeptideAtlasiO95497.
PRIDEiO95497.

PTM databases

PhosphoSiteiO95497.

Expressioni

Tissue specificityi

Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin.1 Publication

Inductioni

By Th17/Th1 type cytokines, but not by Th2-type.1 Publication

Gene expression databases

BgeeiO95497.
CleanExiHS_VNN1.
GenevestigatoriO95497.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000356905.

Structurei

3D structure databases

ProteinModelPortaliO95497.
SMRiO95497. Positions 54-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 328304CN hydrolasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CN hydrolase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0388.
GeneTreeiENSGT00390000013823.
HOVERGENiHBG003996.
InParanoidiO95497.
KOiK08069.
OMAiRYYLQIC.
OrthoDBiEOG7HF1J0.
PhylomeDBiO95497.
TreeFamiTF323645.

Family and domain databases

Gene3Di3.60.110.10. 1 hit.
InterProiIPR012101. Biotinidase_euk.
IPR003010. C-N_Hydrolase.
[Graphical view]
PANTHERiPTHR10609. PTHR10609. 1 hit.
PfamiPF00795. CN_hydrolase. 1 hit.
[Graphical view]
PIRSFiPIRSF011861. Biotinidase. 1 hit.
SUPFAMiSSF56317. SSF56317. 1 hit.
PROSITEiPS50263. CN_HYDROLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95497-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTQLPAYVA ILLFYVSRAS CQDTFTAAVY EHAAILPNAT LTPVSREEAL
60 70 80 90 100
ALMNRNLDIL EGAITSAADQ GAHIIVTPED AIYGWNFNRD SLYPYLEDIP
110 120 130 140 150
DPEVNWIPCN NRNRFGQTPV QERLSCLAKN NSIYVVANIG DKKPCDTSDP
160 170 180 190 200
QCPPDGRYQY NTDVVFDSQG KLVARYHKQN LFMGENQFNV PKEPEIVTFN
210 220 230 240 250
TTFGSFGIFT CFDILFHDPA VTLVKDFHVD TIVFPTAWMN VLPHLSAVEF
260 270 280 290 300
HSAWAMGMRV NFLASNIHYP SKKMTGSGIY APNSSRAFHY DMKTEEGKLL
310 320 330 340 350
LSQLDSHPSH SAVVNWTSYA SSIEALSSGN KEFKGTVFFD EFTFVKLTGV
360 370 380 390 400
AGNYTVCQKD LCCHLSYKMS ENIPNEVYAL GAFDGLHTVE GRYYLQICTL
410 420 430 440 450
LKCKTTNLNT CGDSAETAST RFEMFSLSGT FGTQYVFPEV LLSENQLAPG
460 470 480 490 500
EFQVSTDGRL FSLKPTSGPV LTVTLFGRLY EKDWASNASS GLTAQARIIM
510
LIVIAPIVCS LSW
Length:513
Mass (Da):57,012
Last modified:September 27, 2005 - v2
Checksum:i018D2417C12E403F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti101 – 1011D → N in AAH96268. (PubMed:15489334)Curated
Sequence conflicti113 – 1131N → I in AAY88742. 1 PublicationCurated
Sequence conflicti423 – 4231E → D in AAF21453. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261T → I.4 Publications
Corresponds to variant rs2294757 [ dbSNP | Ensembl ].
VAR_023529
Natural varianti63 – 631A → T.1 Publication
VAR_023967
Natural varianti131 – 1311N → S.2 Publications
Corresponds to variant rs2272996 [ dbSNP | Ensembl ].
VAR_023968
Natural varianti136 – 1361V → L.1 Publication
Corresponds to variant rs45610032 [ dbSNP | Ensembl ].
VAR_023969
Natural varianti146 – 1461D → N.1 Publication
Corresponds to variant rs45624336 [ dbSNP | Ensembl ].
VAR_023970
Natural varianti296 – 2961E → D.1 Publication
Corresponds to variant rs45523444 [ dbSNP | Ensembl ].
VAR_023971
Natural varianti325 – 3251A → E.1 Publication
Corresponds to variant rs34535050 [ dbSNP | Ensembl ].
VAR_023972
Natural varianti336 – 3361T → A.1 Publication
Corresponds to variant rs45562238 [ dbSNP | Ensembl ].
VAR_023973
Natural varianti373 – 3731I → T.1 Publication
Corresponds to variant rs35938565 [ dbSNP | Ensembl ].
VAR_023974

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132099 mRNA. Translation: CAA10568.1.
U39664 mRNA. Translation: AAF21453.1.
AK290425 mRNA. Translation: BAF83114.1.
DQ100297 Genomic DNA. Translation: AAY88742.1.
AL032821 Genomic DNA. Translation: CAB40075.1.
BC096265 mRNA. Translation: AAH96265.1.
BC096266 mRNA. Translation: AAH96266.1.
BC096267 mRNA. Translation: AAH96267.1.
BC096268 mRNA. Translation: AAH96268.1.
CCDSiCCDS5159.1.
RefSeqiNP_004657.2. NM_004666.2.
UniGeneiHs.12114.
Hs.720659.

Genome annotation databases

EnsembliENST00000367928; ENSP00000356905; ENSG00000112299.
GeneIDi8876.
KEGGihsa:8876.
UCSCiuc003qdo.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132099 mRNA. Translation: CAA10568.1 .
U39664 mRNA. Translation: AAF21453.1 .
AK290425 mRNA. Translation: BAF83114.1 .
DQ100297 Genomic DNA. Translation: AAY88742.1 .
AL032821 Genomic DNA. Translation: CAB40075.1 .
BC096265 mRNA. Translation: AAH96265.1 .
BC096266 mRNA. Translation: AAH96266.1 .
BC096267 mRNA. Translation: AAH96267.1 .
BC096268 mRNA. Translation: AAH96268.1 .
CCDSi CCDS5159.1.
RefSeqi NP_004657.2. NM_004666.2.
UniGenei Hs.12114.
Hs.720659.

3D structure databases

ProteinModelPortali O95497.
SMRi O95497. Positions 54-241.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000356905.

PTM databases

PhosphoSitei O95497.

Proteomic databases

PaxDbi O95497.
PeptideAtlasi O95497.
PRIDEi O95497.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367928 ; ENSP00000356905 ; ENSG00000112299 .
GeneIDi 8876.
KEGGi hsa:8876.
UCSCi uc003qdo.3. human.

Organism-specific databases

CTDi 8876.
GeneCardsi GC06M133001.
H-InvDB HIX0022602.
HGNCi HGNC:12705. VNN1.
MIMi 603570. gene.
neXtProti NX_O95497.
PharmGKBi PA37321.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0388.
GeneTreei ENSGT00390000013823.
HOVERGENi HBG003996.
InParanoidi O95497.
KOi K08069.
OMAi RYYLQIC.
OrthoDBi EOG7HF1J0.
PhylomeDBi O95497.
TreeFami TF323645.

Miscellaneous databases

GeneWikii VNN1.
GenomeRNAii 8876.
NextBioi 33325.
PROi O95497.
SOURCEi Search...

Gene expression databases

Bgeei O95497.
CleanExi HS_VNN1.
Genevestigatori O95497.

Family and domain databases

Gene3Di 3.60.110.10. 1 hit.
InterProi IPR012101. Biotinidase_euk.
IPR003010. C-N_Hydrolase.
[Graphical view ]
PANTHERi PTHR10609. PTHR10609. 1 hit.
Pfami PF00795. CN_hydrolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF011861. Biotinidase. 1 hit.
SUPFAMi SSF56317. SSF56317. 1 hit.
PROSITEi PS50263. CN_HYDROLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6."
    Galland F., Malergue F., Bazin H., Mattei M.-G., Aurrand-Lions M., Theillet C., Naquet P.
    Genomics 53:203-213(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-26.
    Tissue: Liver.
  2. "Human Tiff66."
    Prehn S., Friedrichson T., Henske A., Boehm S., Hartmann E., Kurzchalia T.V.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-26.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-26.
    Tissue: Umbilical cord blood.
  4. NIEHS SNPs program
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-26; THR-63; SER-131; LEU-136; ASN-146; ASP-296; GLU-325; ALA-336 AND THR-373.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-131.
  7. "Is pantetheinase the actual identity of mouse and human vanin-1 proteins?"
    Maras B., Barra D., Dupre S., Pitari G.
    FEBS Lett. 461:149-152(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes."
    Martin F., Malergue F., Pitari G., Philippe J.M., Philips S., Chabret C., Granjeaud S., Mattei M.G., Mungall A.J., Naquet P., Galland F.
    Immunogenetics 53:296-306(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-38 AND ASN-353.
    Tissue: Bile.
  10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-130; ASN-283; ASN-315 AND ASN-353.
    Tissue: Plasma.
  11. "Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines."
    Jansen P.A.M., Kamsteeg M., Rodijk-Olthuis D., van Vlijmen-Willems I.M.J.J., de Jongh G.J., Bergers M., Tjabringa G.S., Zeeuwen P.L.J.M., Schalkwijk J.
    J. Invest. Dermatol. 129:2167-2174(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION BY CYTOKINES.
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-353.
    Tissue: Liver.

Entry informationi

Entry nameiVNN1_HUMAN
AccessioniPrimary (citable) accession number: O95497
Secondary accession number(s): A8K310
, Q4JFW6, Q4VAS7, Q4VAS8, Q4VAS9, Q9UF16, Q9UJF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: September 27, 2005
Last modified: October 29, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3