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O95490

- LPHN2_HUMAN

UniProt

O95490 - LPHN2_HUMAN

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Protein
Latrophilin-2
Gene
LPHN2, KIAA0786, LEC1, LPHH1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei824 – 8252Cleavage By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GDB
  2. carbohydrate binding Source: InterPro
  3. latrotoxin receptor activity Source: UniProtKB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: UniProtKB
  2. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Lectin

Protein family/group databases

MEROPSiS63.012.

Names & Taxonomyi

Protein namesi
Recommended name:
Latrophilin-2
Alternative name(s):
Calcium-independent alpha-latrotoxin receptor 2
Short name:
CIRL-2
Latrophilin homolog 1
Lectomedin-1
Gene namesi
Name:LPHN2
Synonyms:KIAA0786, LEC1, LPHH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18582. LPHN2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini39 – 851813Extracellular Reviewed prediction
Add
BLAST
Transmembranei852 – 87221Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini873 – 8808Cytoplasmic Reviewed prediction
Transmembranei881 – 90121Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini902 – 9076Extracellular Reviewed prediction
Transmembranei908 – 92821Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini929 – 95224Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei953 – 97321Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini974 – 99017Extracellular Reviewed prediction
Add
BLAST
Transmembranei991 – 101121Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini1012 – 103726Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1038 – 105821Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini1059 – 10624Extracellular Reviewed prediction
Transmembranei1063 – 108321Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini1084 – 1459376Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38589.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 14591434Latrophilin-2
PRO_0000012910Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi136 ↔ 318 By similarity
Glycosylationi331 – 3311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi520 – 5201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi629 – 6291N-linked (GlcNAc...)1 Publication
Glycosylationi731 – 7311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi744 – 7441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi787 – 7871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi792 – 7921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi813 – 8131N-linked (GlcNAc...) Reviewed prediction
Modified residuei1374 – 13741Phosphoserine By similarity
Modified residuei1430 – 14301Phosphoserine1 Publication

Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO95490.
PaxDbiO95490.
PRIDEiO95490.

PTM databases

PhosphoSiteiO95490.

Expressioni

Tissue specificityi

Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others.1 Publication

Gene expression databases

ArrayExpressiO95490.
BgeeiO95490.
CleanExiHS_LPHN2.
GenevestigatoriO95490.

Organism-specific databases

HPAiHPA013573.

Interactioni

Subunit structurei

Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85) By similarity.

Protein-protein interaction databases

BioGridi116868. 5 interactions.
IntActiO95490. 3 interactions.
MINTiMINT-143559.
STRINGi9606.ENSP00000322270.

Structurei

3D structure databases

ProteinModelPortaliO95490.
SMRiO95490. Positions 30-132, 465-824, 849-1087.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 13090SUEL-type lectin
Add
BLAST
Domaini135 – 394260Olfactomedin-like
Add
BLAST
Domaini784 – 83653GPS
Add
BLAST

Sequence similaritiesi

Contains 1 GPS domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253931.
HOGENOMiHOG000049065.
HOVERGENiHBG052337.
KOiK04593.
OMAiFQMENTD.
PhylomeDBiO95490.
TreeFamiTF351999.

Family and domain databases

InterProiIPR022624. DUF3497.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTiSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00284. OLF. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95490-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVSSGCRMRS LWFIIVISFL PNTEGFSRAA LPFGLVRREL SCEGYSIDLR     50
CPGSDVIMIE SANYGRTDDK ICDADPFQME NTDCYLPDAF KIMTQRCNNR 100
TQCIVVTGSD VFPDPCPGTY KYLEVQYECV PYIFVCPGTL KAIVDSPCIY 150
EAEQKAGAWC KDPLQAADKI YFMPWTPYRT DTLIEYASLE DFQNSRQTTT 200
YKLPNRVDGT GFVVYDGAVF FNKERTRNIV KFDLRTRIKS GEAIINYANY 250
HDTSPYRWGG KTDIDLAVDE NGLWVIYATE QNNGMIVISQ LNPYTLRFEA 300
TWETVYDKRA ASNAFMICGV LYVVRSVYQD NESETGKNSI DYIYNTRLNR 350
GEYVDVPFPN QYQYIAAVDY NPRDNQLYVW NNNFILRYSL EFGPPDPAQV 400
PTTAVTITSS AELFKTIIST TSTTSQKGPM STTVAGSQEG SKGTKPPPAV 450
STTKIPPITN IFPLPERFCE ALDSKGIKWP QTQRGMMVER PCPKGTRGTA 500
SYLCMISTGT WNPKGPDLSN CTSHWVNQLA QKIRSGENAA SLANELAKHT 550
KGPVFAGDVS SSVRLMEQLV DILDAQLQEL KPSEKDSAGR SYNKLQKREK 600
TCRAYLKAIV DTVDNLLRPE ALESWKHMNS SEQAHTATML LDTLEEGAFV 650
LADNLLEPTR VSMPTENIVL EVAVLSTEGQ IQDFKFPLGI KGAGSSIQLS 700
ANTVKQNSRN GLAKLVFIIY RSLGQFLSTE NATIKLGADF IGRNSTIAVN 750
SHVISVSINK ESSRVYLTDP VLFTLPHIDP DNYFNANCSF WNYSERTMMG 800
YWSTQGCKLV DTNKTRTTCA CSHLTNFAIL MAHREIAYKD GVHELLLTVI 850
TWVGIVISLV CLAICIFTFC FFRGLQSDRN TIHKNLCINL FIAEFIFLIG 900
IDKTKYAIAC PIFAGLLHFF FLAAFAWMCL EGVQLYLMLV EVFESEYSRK 950
KYYYVAGYLF PATVVGVSAA IDYKSYGTEK ACWLHVDNYF IWSFIGPVTF 1000
IILLNIIFLV ITLCKMVKHS NTLKPDSSRL ENIKSWVLGA FALLCLLGLT 1050
WSFGLLFINE ETIVMAYLFT IFNAFQGVFI FIFHCALQKK VRKEYGKCFR 1100
HSYCCGGLPT ESPHSSVKAS TTRTSARYSS GTQSRIRRMW NDTVRKQSES 1150
SFISGDINST STLNQGMTGN YLLTNPLLRP HGTNNPYNTL LAETVVCNAP 1200
SAPVFNSPGH SLNNARDTSA MDTLPLNGNF NNSYSLHKGD YNDSVQVVDC 1250
GLSLNDTAFE KMIISELVHN NLRGSSKTHN LELTLPVKPV IGGSSSEDDA 1300
IVADASSLMH SDNPGLELHH KELEAPLIPQ RTHSLLYQPQ KKVKSEGTDS 1350
YVSQLTAEAE DHLQSPNRDS LYTSMPNLRD SPYPESSPDM EEDLSPSRRS 1400
ENEDIYYKSM PNLGAGHQLQ MCYQISRGNS DGYIIPINKE GCIPEGDVRE 1450
GQMQLVTSL 1459
Length:1,459
Mass (Da):163,349
Last modified:April 26, 2004 - v2
Checksum:i30707B7C3C069029
GO
Isoform 2 (identifier: O95490-2) [UniParc]FASTAAdd to Basket

Also known as: Lectomedin-1 gamma

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1167-1209: Missing.

Show »
Length:1,403
Mass (Da):157,178
Checksum:iCE43AB82916D0D35
GO
Isoform 3 (identifier: O95490-3) [UniParc]FASTAAdd to Basket

Also known as: Lectomedin-1 beta

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1134-1136: SRI → DIH
     1137-1459: Missing.

Show »
Length:1,123
Mass (Da):126,163
Checksum:i21DB98B51EBDF4EC
GO
Isoform 4 (identifier: O95490-4) [UniParc]FASTAAdd to Basket

Also known as: Lectomedin-1 alpha

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1167-1209: Missing.
     1210-1233: HSLNNARDTSAMDTLPLNGNFNNS → LTSHGLRAHLQDLYHLELLLGQIA
     1234-1459: Missing.

Show »
Length:1,177
Mass (Da):132,245
Checksum:i6D099178841E1E3A
GO
Isoform 5 (identifier: O95490-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1167-1209: Missing.

Note: No experimental confirmation.

Show »
Length:1,416
Mass (Da):158,797
Checksum:iFB5C1C0A9A9ED3C5
GO
Isoform 6 (identifier: O95490-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1034-1034: K → NNYRVCDGYYNTDLPG

Show »
Length:1,474
Mass (Da):165,067
Checksum:iA78543DA2A149746
GO
Isoform 7 (identifier: O95490-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1034-1034: K → NNYRVCDGYYNTDLPG

Note: No experimental confirmation.

Show »
Length:1,461
Mass (Da):163,448
Checksum:iB528698BA07BBC46
GO

Sequence cautioni

The sequence CAI22406.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei595 – 60713Missing in isoform 2, isoform 3, isoform 4 and isoform 7.
VSP_010104Add
BLAST
Alternative sequencei1034 – 10341K → NNYRVCDGYYNTDLPG in isoform 6 and isoform 7.
VSP_042267
Alternative sequencei1134 – 11363SRI → DIH in isoform 3.
VSP_010105
Alternative sequencei1137 – 1459323Missing in isoform 3.
VSP_010106Add
BLAST
Alternative sequencei1167 – 120943Missing in isoform 2, isoform 4 and isoform 5.
VSP_010107Add
BLAST
Alternative sequencei1210 – 123324HSLNN…NFNNS → LTSHGLRAHLQDLYHLELLL GQIA in isoform 4.
VSP_010108Add
BLAST
Alternative sequencei1234 – 1459226Missing in isoform 4.
VSP_010109Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1059 – 10591N → S in ABL59902. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ131581 mRNA. Translation: CAA10458.1.
AJ244492
, AJ244493, AJ244494, AJ244496, AJ244497, AJ244498, AJ244499, AJ244501, AJ244502, AJ244503, AJ244504, AJ244505, AJ244506, AJ244507, AJ244510, AJ244511, AJ244512, AJ244516 Genomic DNA. Translation: CAB60229.1.
AF104266 mRNA. Translation: AAD54675.1.
AF104938 mRNA. Translation: AAD54676.1.
AF104939 mRNA. Translation: AAD54677.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71340.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71341.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71342.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71343.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71345.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71346.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71347.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22397.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22398.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22399.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22401.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22402.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22403.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22405.1.
AL157903, AC113949 Genomic DNA. Translation: CAI22406.1. Sequence problems.
CH471059 Genomic DNA. Translation: EAX06327.1.
CH471059 Genomic DNA. Translation: EAX06330.1.
CH471059 Genomic DNA. Translation: EAX06333.1.
CH471059 Genomic DNA. Translation: EAX06335.1.
CH471059 Genomic DNA. Translation: EAX06336.1.
CH471059 Genomic DNA. Translation: EAX06339.1.
AB018329 mRNA. Translation: BAA34506.1.
DQ925675 mRNA. Translation: ABL59902.1.
CCDSiCCDS689.1. [O95490-2]
RefSeqiNP_036434.1. NM_012302.2. [O95490-2]
XP_005270723.1. XM_005270666.2. [O95490-1]
XP_005270727.1. XM_005270670.2. [O95490-2]
XP_005270730.1. XM_005270673.2. [O95490-4]
XP_005270731.1. XM_005270674.2. [O95490-4]
XP_006710555.1. XM_006710492.1. [O95490-2]
UniGeneiHs.24212.
Hs.649282.

Genome annotation databases

EnsembliENST00000319517; ENSP00000322270; ENSG00000117114. [O95490-2]
ENST00000335786; ENSP00000337306; ENSG00000117114. [O95490-5]
ENST00000359929; ENSP00000353006; ENSG00000117114. [O95490-2]
ENST00000370713; ENSP00000359748; ENSG00000117114. [O95490-3]
ENST00000370715; ENSP00000359750; ENSG00000117114. [O95490-4]
ENST00000370717; ENSP00000359752; ENSG00000117114. [O95490-6]
ENST00000370723; ENSP00000359758; ENSG00000117114. [O95490-7]
ENST00000370725; ENSP00000359760; ENSG00000117114. [O95490-6]
ENST00000370728; ENSP00000359763; ENSG00000117114. [O95490-1]
ENST00000370730; ENSP00000359765; ENSG00000117114. [O95490-5]
ENST00000394879; ENSP00000378344; ENSG00000117114. [O95490-7]
GeneIDi23266.
KEGGihsa:23266.
UCSCiuc001dit.4. human. [O95490-2]
uc001div.3. human. [O95490-4]
uc001diw.3. human. [O95490-1]
uc009wcd.3. human. [O95490-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ131581 mRNA. Translation: CAA10458.1 .
AJ244492
, AJ244493 , AJ244494 , AJ244496 , AJ244497 , AJ244498 , AJ244499 , AJ244501 , AJ244502 , AJ244503 , AJ244504 , AJ244505 , AJ244506 , AJ244507 , AJ244510 , AJ244511 , AJ244512 , AJ244516 Genomic DNA. Translation: CAB60229.1 .
AF104266 mRNA. Translation: AAD54675.1 .
AF104938 mRNA. Translation: AAD54676.1 .
AF104939 mRNA. Translation: AAD54677.1 .
AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71340.1 .
AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71341.1 .
AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71342.1 .
AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71343.1 .
AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71345.1 .
AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71346.1 .
AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71347.1 .
AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22397.1 .
AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22398.1 .
AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22399.1 .
AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22401.1 .
AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22402.1 .
AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22403.1 .
AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22405.1 .
AL157903 , AC113949 Genomic DNA. Translation: CAI22406.1 . Sequence problems.
CH471059 Genomic DNA. Translation: EAX06327.1 .
CH471059 Genomic DNA. Translation: EAX06330.1 .
CH471059 Genomic DNA. Translation: EAX06333.1 .
CH471059 Genomic DNA. Translation: EAX06335.1 .
CH471059 Genomic DNA. Translation: EAX06336.1 .
CH471059 Genomic DNA. Translation: EAX06339.1 .
AB018329 mRNA. Translation: BAA34506.1 .
DQ925675 mRNA. Translation: ABL59902.1 .
CCDSi CCDS689.1. [O95490-2 ]
RefSeqi NP_036434.1. NM_012302.2. [O95490-2 ]
XP_005270723.1. XM_005270666.2. [O95490-1 ]
XP_005270727.1. XM_005270670.2. [O95490-2 ]
XP_005270730.1. XM_005270673.2. [O95490-4 ]
XP_005270731.1. XM_005270674.2. [O95490-4 ]
XP_006710555.1. XM_006710492.1. [O95490-2 ]
UniGenei Hs.24212.
Hs.649282.

3D structure databases

ProteinModelPortali O95490.
SMRi O95490. Positions 30-132, 465-824, 849-1087.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116868. 5 interactions.
IntActi O95490. 3 interactions.
MINTi MINT-143559.
STRINGi 9606.ENSP00000322270.

Protein family/group databases

MEROPSi S63.012.
GPCRDBi Search...

PTM databases

PhosphoSitei O95490.

Proteomic databases

MaxQBi O95490.
PaxDbi O95490.
PRIDEi O95490.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000319517 ; ENSP00000322270 ; ENSG00000117114 . [O95490-2 ]
ENST00000335786 ; ENSP00000337306 ; ENSG00000117114 . [O95490-5 ]
ENST00000359929 ; ENSP00000353006 ; ENSG00000117114 . [O95490-2 ]
ENST00000370713 ; ENSP00000359748 ; ENSG00000117114 . [O95490-3 ]
ENST00000370715 ; ENSP00000359750 ; ENSG00000117114 . [O95490-4 ]
ENST00000370717 ; ENSP00000359752 ; ENSG00000117114 . [O95490-6 ]
ENST00000370723 ; ENSP00000359758 ; ENSG00000117114 . [O95490-7 ]
ENST00000370725 ; ENSP00000359760 ; ENSG00000117114 . [O95490-6 ]
ENST00000370728 ; ENSP00000359763 ; ENSG00000117114 . [O95490-1 ]
ENST00000370730 ; ENSP00000359765 ; ENSG00000117114 . [O95490-5 ]
ENST00000394879 ; ENSP00000378344 ; ENSG00000117114 . [O95490-7 ]
GeneIDi 23266.
KEGGi hsa:23266.
UCSCi uc001dit.4. human. [O95490-2 ]
uc001div.3. human. [O95490-4 ]
uc001diw.3. human. [O95490-1 ]
uc009wcd.3. human. [O95490-3 ]

Organism-specific databases

CTDi 23266.
GeneCardsi GC01P081771.
HGNCi HGNC:18582. LPHN2.
HPAi HPA013573.
MIMi 607018. gene.
neXtProti NX_O95490.
PharmGKBi PA38589.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG253931.
HOGENOMi HOG000049065.
HOVERGENi HBG052337.
KOi K04593.
OMAi FQMENTD.
PhylomeDBi O95490.
TreeFami TF351999.

Miscellaneous databases

ChiTaRSi LPHN2. human.
GeneWikii LPHN2.
GenomeRNAii 23266.
NextBioi 45018.
PROi O95490.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95490.
Bgeei O95490.
CleanExi HS_LPHN2.
Genevestigatori O95490.

Family and domain databases

InterProi IPR022624. DUF3497.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTi SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00284. OLF. 1 hit.
[Graphical view ]
PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterisation of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer."
    White G.R.M., Varley J.M., Heighway J.
    Oncogene 17:3513-3519(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  2. "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines."
    White G.R.M., Varley J.M., Heighway J.
    Biochim. Biophys. Acta 1491:75-92(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Hayflick J.S.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4).
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 439-1459 (ISOFORM 1).
    Tissue: Brain.
  7. "Discovery of tissue-specific exons using comprehensive human exon microarrays."
    Clark T.A., Schweitzer A.C., Chen T.X., Staples M.K., Lu G., Wang H., Williams A., Blume J.E.
    Genome Biol. 8:R64.1-R64.16(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 973-1070 (ISOFORM 6).
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-629.
    Tissue: Liver.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1430, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLPHN2_HUMAN
AccessioniPrimary (citable) accession number: O95490
Secondary accession number(s): A5XEI2
, B1ALT8, B1ALT9, B1ALU0, B1ALU2, B1ALU4, B1ALU5, B1ALU6, O94882, Q5VX76, Q9UKY5, Q9UKY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: July 9, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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