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O95490

- LPHN2_HUMAN

UniProt

O95490 - LPHN2_HUMAN

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Protein

Latrophilin-2

Gene

LPHN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei824 – 8252CleavageBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. G-protein coupled receptor activity Source: GDB
  3. latrotoxin receptor activity Source: UniProtKB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: UniProtKB
  2. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Lectin

Protein family/group databases

MEROPSiS63.012.

Names & Taxonomyi

Protein namesi
Recommended name:
Latrophilin-2
Alternative name(s):
Calcium-independent alpha-latrotoxin receptor 2
Short name:
CIRL-2
Latrophilin homolog 1
Lectomedin-1
Gene namesi
Name:LPHN2
Synonyms:KIAA0786, LEC1, LPHH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18582. LPHN2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini39 – 851813ExtracellularSequence AnalysisAdd
BLAST
Transmembranei852 – 87221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini873 – 8808CytoplasmicSequence Analysis
Transmembranei881 – 90121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini902 – 9076ExtracellularSequence Analysis
Transmembranei908 – 92821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini929 – 95224CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei953 – 97321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini974 – 99017ExtracellularSequence AnalysisAdd
BLAST
Transmembranei991 – 101121Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini1012 – 103726CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei1038 – 105821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini1059 – 10624ExtracellularSequence Analysis
Transmembranei1063 – 108321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini1084 – 1459376CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38589.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 14591434Latrophilin-2PRO_0000012910Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi136 ↔ 318PROSITE-ProRule annotation
Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi520 – 5201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi629 – 6291N-linked (GlcNAc...)1 Publication
Glycosylationi731 – 7311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi744 – 7441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi787 – 7871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi792 – 7921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi813 – 8131N-linked (GlcNAc...)Sequence Analysis
Modified residuei1374 – 13741PhosphoserineBy similarity
Modified residuei1430 – 14301Phosphoserine1 Publication

Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO95490.
PaxDbiO95490.
PRIDEiO95490.

PTM databases

PhosphoSiteiO95490.

Expressioni

Tissue specificityi

Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others.1 Publication

Gene expression databases

BgeeiO95490.
CleanExiHS_LPHN2.
ExpressionAtlasiO95490. baseline and differential.
GenevestigatoriO95490.

Organism-specific databases

HPAiHPA013573.

Interactioni

Subunit structurei

Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85).By similarity

Protein-protein interaction databases

BioGridi116868. 5 interactions.
IntActiO95490. 3 interactions.
MINTiMINT-143559.
STRINGi9606.ENSP00000322270.

Structurei

3D structure databases

ProteinModelPortaliO95490.
SMRiO95490. Positions 30-132, 465-824, 849-1087.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 13090SUEL-type lectinPROSITE-ProRule annotationAdd
BLAST
Domaini135 – 394260Olfactomedin-likePROSITE-ProRule annotationAdd
BLAST
Domaini784 – 83653GPSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 1 olfactomedin-like domain.PROSITE-ProRule annotation
Contains 1 SUEL-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253931.
GeneTreeiENSGT00760000118787.
HOGENOMiHOG000049065.
HOVERGENiHBG052337.
InParanoidiO95490.
KOiK04593.
OMAiFQMENTD.
PhylomeDBiO95490.
TreeFamiTF351999.

Family and domain databases

InterProiIPR022624. DUF3497.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTiSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00284. OLF. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95490-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSSGCRMRS LWFIIVISFL PNTEGFSRAA LPFGLVRREL SCEGYSIDLR
60 70 80 90 100
CPGSDVIMIE SANYGRTDDK ICDADPFQME NTDCYLPDAF KIMTQRCNNR
110 120 130 140 150
TQCIVVTGSD VFPDPCPGTY KYLEVQYECV PYIFVCPGTL KAIVDSPCIY
160 170 180 190 200
EAEQKAGAWC KDPLQAADKI YFMPWTPYRT DTLIEYASLE DFQNSRQTTT
210 220 230 240 250
YKLPNRVDGT GFVVYDGAVF FNKERTRNIV KFDLRTRIKS GEAIINYANY
260 270 280 290 300
HDTSPYRWGG KTDIDLAVDE NGLWVIYATE QNNGMIVISQ LNPYTLRFEA
310 320 330 340 350
TWETVYDKRA ASNAFMICGV LYVVRSVYQD NESETGKNSI DYIYNTRLNR
360 370 380 390 400
GEYVDVPFPN QYQYIAAVDY NPRDNQLYVW NNNFILRYSL EFGPPDPAQV
410 420 430 440 450
PTTAVTITSS AELFKTIIST TSTTSQKGPM STTVAGSQEG SKGTKPPPAV
460 470 480 490 500
STTKIPPITN IFPLPERFCE ALDSKGIKWP QTQRGMMVER PCPKGTRGTA
510 520 530 540 550
SYLCMISTGT WNPKGPDLSN CTSHWVNQLA QKIRSGENAA SLANELAKHT
560 570 580 590 600
KGPVFAGDVS SSVRLMEQLV DILDAQLQEL KPSEKDSAGR SYNKLQKREK
610 620 630 640 650
TCRAYLKAIV DTVDNLLRPE ALESWKHMNS SEQAHTATML LDTLEEGAFV
660 670 680 690 700
LADNLLEPTR VSMPTENIVL EVAVLSTEGQ IQDFKFPLGI KGAGSSIQLS
710 720 730 740 750
ANTVKQNSRN GLAKLVFIIY RSLGQFLSTE NATIKLGADF IGRNSTIAVN
760 770 780 790 800
SHVISVSINK ESSRVYLTDP VLFTLPHIDP DNYFNANCSF WNYSERTMMG
810 820 830 840 850
YWSTQGCKLV DTNKTRTTCA CSHLTNFAIL MAHREIAYKD GVHELLLTVI
860 870 880 890 900
TWVGIVISLV CLAICIFTFC FFRGLQSDRN TIHKNLCINL FIAEFIFLIG
910 920 930 940 950
IDKTKYAIAC PIFAGLLHFF FLAAFAWMCL EGVQLYLMLV EVFESEYSRK
960 970 980 990 1000
KYYYVAGYLF PATVVGVSAA IDYKSYGTEK ACWLHVDNYF IWSFIGPVTF
1010 1020 1030 1040 1050
IILLNIIFLV ITLCKMVKHS NTLKPDSSRL ENIKSWVLGA FALLCLLGLT
1060 1070 1080 1090 1100
WSFGLLFINE ETIVMAYLFT IFNAFQGVFI FIFHCALQKK VRKEYGKCFR
1110 1120 1130 1140 1150
HSYCCGGLPT ESPHSSVKAS TTRTSARYSS GTQSRIRRMW NDTVRKQSES
1160 1170 1180 1190 1200
SFISGDINST STLNQGMTGN YLLTNPLLRP HGTNNPYNTL LAETVVCNAP
1210 1220 1230 1240 1250
SAPVFNSPGH SLNNARDTSA MDTLPLNGNF NNSYSLHKGD YNDSVQVVDC
1260 1270 1280 1290 1300
GLSLNDTAFE KMIISELVHN NLRGSSKTHN LELTLPVKPV IGGSSSEDDA
1310 1320 1330 1340 1350
IVADASSLMH SDNPGLELHH KELEAPLIPQ RTHSLLYQPQ KKVKSEGTDS
1360 1370 1380 1390 1400
YVSQLTAEAE DHLQSPNRDS LYTSMPNLRD SPYPESSPDM EEDLSPSRRS
1410 1420 1430 1440 1450
ENEDIYYKSM PNLGAGHQLQ MCYQISRGNS DGYIIPINKE GCIPEGDVRE

GQMQLVTSL
Length:1,459
Mass (Da):163,349
Last modified:April 26, 2004 - v2
Checksum:i30707B7C3C069029
GO
Isoform 2 (identifier: O95490-2) [UniParc]FASTAAdd to Basket

Also known as: Lectomedin-1 gamma

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1167-1209: Missing.

Show »
Length:1,403
Mass (Da):157,178
Checksum:iCE43AB82916D0D35
GO
Isoform 3 (identifier: O95490-3) [UniParc]FASTAAdd to Basket

Also known as: Lectomedin-1 beta

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1134-1136: SRI → DIH
     1137-1459: Missing.

Show »
Length:1,123
Mass (Da):126,163
Checksum:i21DB98B51EBDF4EC
GO
Isoform 4 (identifier: O95490-4) [UniParc]FASTAAdd to Basket

Also known as: Lectomedin-1 alpha

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1167-1209: Missing.
     1210-1233: HSLNNARDTSAMDTLPLNGNFNNS → LTSHGLRAHLQDLYHLELLLGQIA
     1234-1459: Missing.

Show »
Length:1,177
Mass (Da):132,245
Checksum:i6D099178841E1E3A
GO
Isoform 5 (identifier: O95490-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1167-1209: Missing.

Note: No experimental confirmation.

Show »
Length:1,416
Mass (Da):158,797
Checksum:iFB5C1C0A9A9ED3C5
GO
Isoform 6 (identifier: O95490-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1034-1034: K → NNYRVCDGYYNTDLPG

Show »
Length:1,474
Mass (Da):165,067
Checksum:iA78543DA2A149746
GO
Isoform 7 (identifier: O95490-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1034-1034: K → NNYRVCDGYYNTDLPG

Note: No experimental confirmation.

Show »
Length:1,461
Mass (Da):163,448
Checksum:iB528698BA07BBC46
GO

Sequence cautioni

The sequence CAI22406.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1059 – 10591N → S in ABL59902. (PubMed:17456239)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei595 – 60713Missing in isoform 2, isoform 3, isoform 4 and isoform 7. 2 PublicationsVSP_010104Add
BLAST
Alternative sequencei1034 – 10341K → NNYRVCDGYYNTDLPG in isoform 6 and isoform 7. 1 PublicationVSP_042267
Alternative sequencei1134 – 11363SRI → DIH in isoform 3. 1 PublicationVSP_010105
Alternative sequencei1137 – 1459323Missing in isoform 3. 1 PublicationVSP_010106Add
BLAST
Alternative sequencei1167 – 120943Missing in isoform 2, isoform 4 and isoform 5. 2 PublicationsVSP_010107Add
BLAST
Alternative sequencei1210 – 123324HSLNN…NFNNS → LTSHGLRAHLQDLYHLELLL GQIA in isoform 4. 1 PublicationVSP_010108Add
BLAST
Alternative sequencei1234 – 1459226Missing in isoform 4. 1 PublicationVSP_010109Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131581 mRNA. Translation: CAA10458.1.
AJ244492
, AJ244493, AJ244494, AJ244496, AJ244497, AJ244498, AJ244499, AJ244501, AJ244502, AJ244503, AJ244504, AJ244505, AJ244506, AJ244507, AJ244510, AJ244511, AJ244512, AJ244516 Genomic DNA. Translation: CAB60229.1.
AF104266 mRNA. Translation: AAD54675.1.
AF104938 mRNA. Translation: AAD54676.1.
AF104939 mRNA. Translation: AAD54677.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71340.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71341.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71342.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71343.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71345.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71346.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71347.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22397.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22398.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22399.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22401.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22402.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22403.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22405.1.
AL157903, AC113949 Genomic DNA. Translation: CAI22406.1. Sequence problems.
CH471059 Genomic DNA. Translation: EAX06327.1.
CH471059 Genomic DNA. Translation: EAX06330.1.
CH471059 Genomic DNA. Translation: EAX06333.1.
CH471059 Genomic DNA. Translation: EAX06335.1.
CH471059 Genomic DNA. Translation: EAX06336.1.
CH471059 Genomic DNA. Translation: EAX06339.1.
AB018329 mRNA. Translation: BAA34506.1.
DQ925675 mRNA. Translation: ABL59902.1.
CCDSiCCDS689.1. [O95490-2]
CCDS72811.1. [O95490-4]
RefSeqiNP_001284633.1. NM_001297704.1. [O95490-2]
NP_001284634.1. NM_001297705.1. [O95490-4]
NP_001284635.1. NM_001297706.1. [O95490-3]
NP_036434.1. NM_012302.3. [O95490-2]
XP_005270723.1. XM_005270666.2. [O95490-1]
XP_005270727.1. XM_005270670.2. [O95490-2]
XP_005270730.1. XM_005270673.2. [O95490-4]
UniGeneiHs.24212.
Hs.649282.

Genome annotation databases

EnsembliENST00000319517; ENSP00000322270; ENSG00000117114. [O95490-2]
ENST00000359929; ENSP00000353006; ENSG00000117114. [O95490-2]
ENST00000370713; ENSP00000359748; ENSG00000117114. [O95490-3]
ENST00000370715; ENSP00000359750; ENSG00000117114. [O95490-4]
ENST00000370717; ENSP00000359752; ENSG00000117114. [O95490-1]
ENST00000370723; ENSP00000359758; ENSG00000117114. [O95490-7]
ENST00000370725; ENSP00000359760; ENSG00000117114. [O95490-6]
ENST00000370728; ENSP00000359763; ENSG00000117114. [O95490-1]
ENST00000370730; ENSP00000359765; ENSG00000117114. [O95490-5]
GeneIDi23266.
KEGGihsa:23266.
UCSCiuc001dit.4. human. [O95490-2]
uc001div.3. human. [O95490-4]
uc001diw.3. human. [O95490-1]
uc009wcd.3. human. [O95490-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131581 mRNA. Translation: CAA10458.1 .
AJ244492
, AJ244493 , AJ244494 , AJ244496 , AJ244497 , AJ244498 , AJ244499 , AJ244501 , AJ244502 , AJ244503 , AJ244504 , AJ244505 , AJ244506 , AJ244507 , AJ244510 , AJ244511 , AJ244512 , AJ244516 Genomic DNA. Translation: CAB60229.1 .
AF104266 mRNA. Translation: AAD54675.1 .
AF104938 mRNA. Translation: AAD54676.1 .
AF104939 mRNA. Translation: AAD54677.1 .
AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71340.1 .
AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71341.1 .
AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71342.1 .
AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71343.1 .
AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71345.1 .
AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71346.1 .
AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71347.1 .
AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22397.1 .
AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22398.1 .
AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22399.1 .
AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22401.1 .
AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22402.1 .
AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22403.1 .
AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22405.1 .
AL157903 , AC113949 Genomic DNA. Translation: CAI22406.1 . Sequence problems.
CH471059 Genomic DNA. Translation: EAX06327.1 .
CH471059 Genomic DNA. Translation: EAX06330.1 .
CH471059 Genomic DNA. Translation: EAX06333.1 .
CH471059 Genomic DNA. Translation: EAX06335.1 .
CH471059 Genomic DNA. Translation: EAX06336.1 .
CH471059 Genomic DNA. Translation: EAX06339.1 .
AB018329 mRNA. Translation: BAA34506.1 .
DQ925675 mRNA. Translation: ABL59902.1 .
CCDSi CCDS689.1. [O95490-2 ]
CCDS72811.1. [O95490-4 ]
RefSeqi NP_001284633.1. NM_001297704.1. [O95490-2 ]
NP_001284634.1. NM_001297705.1. [O95490-4 ]
NP_001284635.1. NM_001297706.1. [O95490-3 ]
NP_036434.1. NM_012302.3. [O95490-2 ]
XP_005270723.1. XM_005270666.2. [O95490-1 ]
XP_005270727.1. XM_005270670.2. [O95490-2 ]
XP_005270730.1. XM_005270673.2. [O95490-4 ]
UniGenei Hs.24212.
Hs.649282.

3D structure databases

ProteinModelPortali O95490.
SMRi O95490. Positions 30-132, 465-824, 849-1087.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116868. 5 interactions.
IntActi O95490. 3 interactions.
MINTi MINT-143559.
STRINGi 9606.ENSP00000322270.

Protein family/group databases

MEROPSi S63.012.
GPCRDBi Search...

PTM databases

PhosphoSitei O95490.

Proteomic databases

MaxQBi O95490.
PaxDbi O95490.
PRIDEi O95490.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000319517 ; ENSP00000322270 ; ENSG00000117114 . [O95490-2 ]
ENST00000359929 ; ENSP00000353006 ; ENSG00000117114 . [O95490-2 ]
ENST00000370713 ; ENSP00000359748 ; ENSG00000117114 . [O95490-3 ]
ENST00000370715 ; ENSP00000359750 ; ENSG00000117114 . [O95490-4 ]
ENST00000370717 ; ENSP00000359752 ; ENSG00000117114 . [O95490-1 ]
ENST00000370723 ; ENSP00000359758 ; ENSG00000117114 . [O95490-7 ]
ENST00000370725 ; ENSP00000359760 ; ENSG00000117114 . [O95490-6 ]
ENST00000370728 ; ENSP00000359763 ; ENSG00000117114 . [O95490-1 ]
ENST00000370730 ; ENSP00000359765 ; ENSG00000117114 . [O95490-5 ]
GeneIDi 23266.
KEGGi hsa:23266.
UCSCi uc001dit.4. human. [O95490-2 ]
uc001div.3. human. [O95490-4 ]
uc001diw.3. human. [O95490-1 ]
uc009wcd.3. human. [O95490-3 ]

Organism-specific databases

CTDi 23266.
GeneCardsi GC01P081771.
HGNCi HGNC:18582. LPHN2.
HPAi HPA013573.
MIMi 607018. gene.
neXtProti NX_O95490.
PharmGKBi PA38589.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG253931.
GeneTreei ENSGT00760000118787.
HOGENOMi HOG000049065.
HOVERGENi HBG052337.
InParanoidi O95490.
KOi K04593.
OMAi FQMENTD.
PhylomeDBi O95490.
TreeFami TF351999.

Miscellaneous databases

ChiTaRSi LPHN2. human.
GeneWikii LPHN2.
GenomeRNAii 23266.
NextBioi 45018.
PROi O95490.
SOURCEi Search...

Gene expression databases

Bgeei O95490.
CleanExi HS_LPHN2.
ExpressionAtlasi O95490. baseline and differential.
Genevestigatori O95490.

Family and domain databases

InterProi IPR022624. DUF3497.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTi SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00284. OLF. 1 hit.
[Graphical view ]
PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterisation of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer."
    White G.R.M., Varley J.M., Heighway J.
    Oncogene 17:3513-3519(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  2. "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines."
    White G.R.M., Varley J.M., Heighway J.
    Biochim. Biophys. Acta 1491:75-92(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Hayflick J.S.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4).
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 439-1459 (ISOFORM 1).
    Tissue: Brain.
  7. "Discovery of tissue-specific exons using comprehensive human exon microarrays."
    Clark T.A., Schweitzer A.C., Chen T.X., Staples M.K., Lu G., Wang H., Williams A., Blume J.E.
    Genome Biol. 8:R64.1-R64.16(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 973-1070 (ISOFORM 6).
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-629.
    Tissue: Liver.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1430, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLPHN2_HUMAN
AccessioniPrimary (citable) accession number: O95490
Secondary accession number(s): A5XEI2
, B1ALT8, B1ALT9, B1ALU0, B1ALU2, B1ALU4, B1ALU5, B1ALU6, O94882, Q5VX76, Q9UKY5, Q9UKY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: November 26, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3