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Protein

Adhesion G protein-coupled receptor L2

Gene

ADGRL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis.By similarity

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • G-protein coupled receptor activity Source: GDB
  • latrotoxin receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117114-MONOMER.

Protein family/group databases

MEROPSiP02.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor L21 Publication
Alternative name(s):
Calcium-independent alpha-latrotoxin receptor 2
Short name:
CIRL-2
Latrophilin homolog 1
Latrophilin-2
Lectomedin-1
Gene namesi
Name:ADGRL2Imported
Synonyms:KIAA0786, LEC1, LPHH1, LPHN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18582. ADGRL2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 851ExtracellularCuratedAdd BLAST826
Transmembranei852 – 872Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini873 – 880CytoplasmicCurated8
Transmembranei881 – 901Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini902 – 907ExtracellularCurated6
Transmembranei908 – 928Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini929 – 952CytoplasmicCuratedAdd BLAST24
Transmembranei953 – 973Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini974 – 990ExtracellularCuratedAdd BLAST17
Transmembranei991 – 1011Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1012 – 1037CytoplasmicCuratedAdd BLAST26
Transmembranei1038 – 1058Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1059 – 1062ExtracellularCurated4
Transmembranei1063 – 1083Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1084 – 1459CytoplasmicCuratedAdd BLAST376

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23266.
OpenTargetsiENSG00000117114.
PharmGKBiPA38589.

Polymorphism and mutation databases

BioMutaiLPHN2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001291026 – 1459Adhesion G protein-coupled receptor L2Add BLAST1434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi136 ↔ 318PROSITE-ProRule annotation
Glycosylationi331N-linked (GlcNAc...)Sequence analysis1
Glycosylationi520N-linked (GlcNAc...)Sequence analysis1
Glycosylationi629N-linked (GlcNAc...)1 Publication1
Glycosylationi731N-linked (GlcNAc...)Sequence analysis1
Glycosylationi744N-linked (GlcNAc...)Sequence analysis1
Glycosylationi787N-linked (GlcNAc...)Sequence analysis1
Glycosylationi792N-linked (GlcNAc...)Sequence analysis1
Glycosylationi813N-linked (GlcNAc...)Sequence analysis1
Modified residuei1374PhosphoserineBy similarity1
Modified residuei1409PhosphoserineBy similarity1
Modified residuei1430PhosphoserineCombined sources1

Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei824 – 825CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO95490.
MaxQBiO95490.
PaxDbiO95490.
PeptideAtlasiO95490.
PRIDEiO95490.

PTM databases

iPTMnetiO95490.
PhosphoSitePlusiO95490.

Expressioni

Tissue specificityi

Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others.1 Publication

Gene expression databases

BgeeiENSG00000117114.
CleanExiHS_LPHN2.
ExpressionAtlasiO95490. baseline and differential.
GenevisibleiO95490. HS.

Organism-specific databases

HPAiHPA013573.
HPA043447.

Interactioni

Subunit structurei

Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety.By similarity

Protein-protein interaction databases

BioGridi116868. 9 interactors.
IntActiO95490. 7 interactors.
MINTiMINT-143559.
STRINGi9606.ENSP00000322270.

Structurei

3D structure databases

ProteinModelPortaliO95490.
SMRiO95490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 130SUEL-type lectinPROSITE-ProRule annotationAdd BLAST90
Domaini135 – 394Olfactomedin-likePROSITE-ProRule annotationAdd BLAST260
Domaini784 – 836GPSPROSITE-ProRule annotationAdd BLAST53

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 1 olfactomedin-like domain.PROSITE-ProRule annotation
Contains 1 SUEL-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3545. Eukaryota.
KOG4193. Eukaryota.
KOG4729. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000049065.
HOVERGENiHBG052337.
InParanoidiO95490.
KOiK04593.
OMAiYFNANCS.
OrthoDBiEOG091G00GJ.
PhylomeDBiO95490.
TreeFamiTF351999.

Family and domain databases

InterProiIPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR031240. Latrophilin-2.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like_dom.
[Graphical view]
PANTHERiPTHR12011:SF61. PTHR12011:SF61. 2 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF16489. GAIN. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTiSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00284. OLF. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95490-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSSGCRMRS LWFIIVISFL PNTEGFSRAA LPFGLVRREL SCEGYSIDLR
60 70 80 90 100
CPGSDVIMIE SANYGRTDDK ICDADPFQME NTDCYLPDAF KIMTQRCNNR
110 120 130 140 150
TQCIVVTGSD VFPDPCPGTY KYLEVQYECV PYIFVCPGTL KAIVDSPCIY
160 170 180 190 200
EAEQKAGAWC KDPLQAADKI YFMPWTPYRT DTLIEYASLE DFQNSRQTTT
210 220 230 240 250
YKLPNRVDGT GFVVYDGAVF FNKERTRNIV KFDLRTRIKS GEAIINYANY
260 270 280 290 300
HDTSPYRWGG KTDIDLAVDE NGLWVIYATE QNNGMIVISQ LNPYTLRFEA
310 320 330 340 350
TWETVYDKRA ASNAFMICGV LYVVRSVYQD NESETGKNSI DYIYNTRLNR
360 370 380 390 400
GEYVDVPFPN QYQYIAAVDY NPRDNQLYVW NNNFILRYSL EFGPPDPAQV
410 420 430 440 450
PTTAVTITSS AELFKTIIST TSTTSQKGPM STTVAGSQEG SKGTKPPPAV
460 470 480 490 500
STTKIPPITN IFPLPERFCE ALDSKGIKWP QTQRGMMVER PCPKGTRGTA
510 520 530 540 550
SYLCMISTGT WNPKGPDLSN CTSHWVNQLA QKIRSGENAA SLANELAKHT
560 570 580 590 600
KGPVFAGDVS SSVRLMEQLV DILDAQLQEL KPSEKDSAGR SYNKLQKREK
610 620 630 640 650
TCRAYLKAIV DTVDNLLRPE ALESWKHMNS SEQAHTATML LDTLEEGAFV
660 670 680 690 700
LADNLLEPTR VSMPTENIVL EVAVLSTEGQ IQDFKFPLGI KGAGSSIQLS
710 720 730 740 750
ANTVKQNSRN GLAKLVFIIY RSLGQFLSTE NATIKLGADF IGRNSTIAVN
760 770 780 790 800
SHVISVSINK ESSRVYLTDP VLFTLPHIDP DNYFNANCSF WNYSERTMMG
810 820 830 840 850
YWSTQGCKLV DTNKTRTTCA CSHLTNFAIL MAHREIAYKD GVHELLLTVI
860 870 880 890 900
TWVGIVISLV CLAICIFTFC FFRGLQSDRN TIHKNLCINL FIAEFIFLIG
910 920 930 940 950
IDKTKYAIAC PIFAGLLHFF FLAAFAWMCL EGVQLYLMLV EVFESEYSRK
960 970 980 990 1000
KYYYVAGYLF PATVVGVSAA IDYKSYGTEK ACWLHVDNYF IWSFIGPVTF
1010 1020 1030 1040 1050
IILLNIIFLV ITLCKMVKHS NTLKPDSSRL ENIKSWVLGA FALLCLLGLT
1060 1070 1080 1090 1100
WSFGLLFINE ETIVMAYLFT IFNAFQGVFI FIFHCALQKK VRKEYGKCFR
1110 1120 1130 1140 1150
HSYCCGGLPT ESPHSSVKAS TTRTSARYSS GTQSRIRRMW NDTVRKQSES
1160 1170 1180 1190 1200
SFISGDINST STLNQGMTGN YLLTNPLLRP HGTNNPYNTL LAETVVCNAP
1210 1220 1230 1240 1250
SAPVFNSPGH SLNNARDTSA MDTLPLNGNF NNSYSLHKGD YNDSVQVVDC
1260 1270 1280 1290 1300
GLSLNDTAFE KMIISELVHN NLRGSSKTHN LELTLPVKPV IGGSSSEDDA
1310 1320 1330 1340 1350
IVADASSLMH SDNPGLELHH KELEAPLIPQ RTHSLLYQPQ KKVKSEGTDS
1360 1370 1380 1390 1400
YVSQLTAEAE DHLQSPNRDS LYTSMPNLRD SPYPESSPDM EEDLSPSRRS
1410 1420 1430 1440 1450
ENEDIYYKSM PNLGAGHQLQ MCYQISRGNS DGYIIPINKE GCIPEGDVRE

GQMQLVTSL
Length:1,459
Mass (Da):163,349
Last modified:April 26, 2004 - v2
Checksum:i30707B7C3C069029
GO
Isoform 2 (identifier: O95490-2) [UniParc]FASTAAdd to basket
Also known as: Lectomedin-1 gamma

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1167-1209: Missing.

Show »
Length:1,403
Mass (Da):157,178
Checksum:iCE43AB82916D0D35
GO
Isoform 3 (identifier: O95490-3) [UniParc]FASTAAdd to basket
Also known as: Lectomedin-1 beta

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1134-1136: SRI → DIH
     1137-1459: Missing.

Show »
Length:1,123
Mass (Da):126,163
Checksum:i21DB98B51EBDF4EC
GO
Isoform 4 (identifier: O95490-4) [UniParc]FASTAAdd to basket
Also known as: Lectomedin-1 alpha

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1167-1209: Missing.
     1210-1233: HSLNNARDTSAMDTLPLNGNFNNS → LTSHGLRAHLQDLYHLELLLGQIA
     1234-1459: Missing.

Show »
Length:1,177
Mass (Da):132,245
Checksum:i6D099178841E1E3A
GO
Isoform 5 (identifier: O95490-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1167-1209: Missing.

Note: No experimental confirmation.
Show »
Length:1,416
Mass (Da):158,797
Checksum:iFB5C1C0A9A9ED3C5
GO
Isoform 6 (identifier: O95490-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1034-1034: K → NNYRVCDGYYNTDLPG

Show »
Length:1,474
Mass (Da):165,067
Checksum:iA78543DA2A149746
GO
Isoform 7 (identifier: O95490-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     595-607: Missing.
     1034-1034: K → NNYRVCDGYYNTDLPG

Note: No experimental confirmation.
Show »
Length:1,461
Mass (Da):163,448
Checksum:iB528698BA07BBC46
GO

Sequence cautioni

The sequence CAI22406 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1059N → S in ABL59902 (PubMed:17456239).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010104595 – 607Missing in isoform 2, isoform 3, isoform 4 and isoform 7. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_0422671034K → NNYRVCDGYYNTDLPG in isoform 6 and isoform 7. 1 Publication1
Alternative sequenceiVSP_0101051134 – 1136SRI → DIH in isoform 3. 1 Publication3
Alternative sequenceiVSP_0101061137 – 1459Missing in isoform 3. 1 PublicationAdd BLAST323
Alternative sequenceiVSP_0101071167 – 1209Missing in isoform 2, isoform 4 and isoform 5. 2 PublicationsAdd BLAST43
Alternative sequenceiVSP_0101081210 – 1233HSLNN…NFNNS → LTSHGLRAHLQDLYHLELLL GQIA in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_0101091234 – 1459Missing in isoform 4. 1 PublicationAdd BLAST226

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131581 mRNA. Translation: CAA10458.1.
AJ244492
, AJ244493, AJ244494, AJ244496, AJ244497, AJ244498, AJ244499, AJ244501, AJ244502, AJ244503, AJ244504, AJ244505, AJ244506, AJ244507, AJ244510, AJ244511, AJ244512, AJ244516 Genomic DNA. Translation: CAB60229.1.
AF104266 mRNA. Translation: AAD54675.1.
AF104938 mRNA. Translation: AAD54676.1.
AF104939 mRNA. Translation: AAD54677.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71340.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71341.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71342.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71343.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71345.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71346.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71347.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22397.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22398.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22399.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22401.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22402.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22403.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22405.1.
AL157903, AC113949 Genomic DNA. Translation: CAI22406.1. Sequence problems.
CH471059 Genomic DNA. Translation: EAX06327.1.
CH471059 Genomic DNA. Translation: EAX06330.1.
CH471059 Genomic DNA. Translation: EAX06333.1.
CH471059 Genomic DNA. Translation: EAX06335.1.
CH471059 Genomic DNA. Translation: EAX06336.1.
CH471059 Genomic DNA. Translation: EAX06339.1.
AB018329 mRNA. Translation: BAA34506.1.
DQ925675 mRNA. Translation: ABL59902.1.
CCDSiCCDS689.1. [O95490-2]
CCDS72811.1. [O95490-4]
CCDS76174.1. [O95490-3]
CCDS81345.1. [O95490-5]
RefSeqiNP_001284633.1. NM_001297704.1. [O95490-2]
NP_001284634.1. NM_001297705.1. [O95490-4]
NP_001284635.1. NM_001297706.1. [O95490-3]
NP_001317574.1. NM_001330645.1.
NP_036434.1. NM_012302.3. [O95490-2]
XP_005270723.1. XM_005270666.4. [O95490-1]
XP_016856276.1. XM_017000787.1. [O95490-1]
UniGeneiHs.24212.
Hs.649282.

Genome annotation databases

EnsembliENST00000319517; ENSP00000322270; ENSG00000117114. [O95490-2]
ENST00000359929; ENSP00000353006; ENSG00000117114. [O95490-2]
ENST00000370713; ENSP00000359748; ENSG00000117114. [O95490-3]
ENST00000370715; ENSP00000359750; ENSG00000117114. [O95490-4]
ENST00000370717; ENSP00000359752; ENSG00000117114. [O95490-1]
ENST00000370723; ENSP00000359758; ENSG00000117114. [O95490-7]
ENST00000370725; ENSP00000359760; ENSG00000117114. [O95490-6]
ENST00000370728; ENSP00000359763; ENSG00000117114. [O95490-1]
ENST00000370730; ENSP00000359765; ENSG00000117114. [O95490-5]
GeneIDi23266.
KEGGihsa:23266.
UCSCiuc001dit.5. human. [O95490-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131581 mRNA. Translation: CAA10458.1.
AJ244492
, AJ244493, AJ244494, AJ244496, AJ244497, AJ244498, AJ244499, AJ244501, AJ244502, AJ244503, AJ244504, AJ244505, AJ244506, AJ244507, AJ244510, AJ244511, AJ244512, AJ244516 Genomic DNA. Translation: CAB60229.1.
AF104266 mRNA. Translation: AAD54675.1.
AF104938 mRNA. Translation: AAD54676.1.
AF104939 mRNA. Translation: AAD54677.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71340.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71341.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71342.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71343.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71345.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71346.1.
AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71347.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22397.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22398.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22399.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22401.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22402.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22403.1.
AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22405.1.
AL157903, AC113949 Genomic DNA. Translation: CAI22406.1. Sequence problems.
CH471059 Genomic DNA. Translation: EAX06327.1.
CH471059 Genomic DNA. Translation: EAX06330.1.
CH471059 Genomic DNA. Translation: EAX06333.1.
CH471059 Genomic DNA. Translation: EAX06335.1.
CH471059 Genomic DNA. Translation: EAX06336.1.
CH471059 Genomic DNA. Translation: EAX06339.1.
AB018329 mRNA. Translation: BAA34506.1.
DQ925675 mRNA. Translation: ABL59902.1.
CCDSiCCDS689.1. [O95490-2]
CCDS72811.1. [O95490-4]
CCDS76174.1. [O95490-3]
CCDS81345.1. [O95490-5]
RefSeqiNP_001284633.1. NM_001297704.1. [O95490-2]
NP_001284634.1. NM_001297705.1. [O95490-4]
NP_001284635.1. NM_001297706.1. [O95490-3]
NP_001317574.1. NM_001330645.1.
NP_036434.1. NM_012302.3. [O95490-2]
XP_005270723.1. XM_005270666.4. [O95490-1]
XP_016856276.1. XM_017000787.1. [O95490-1]
UniGeneiHs.24212.
Hs.649282.

3D structure databases

ProteinModelPortaliO95490.
SMRiO95490.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116868. 9 interactors.
IntActiO95490. 7 interactors.
MINTiMINT-143559.
STRINGi9606.ENSP00000322270.

Protein family/group databases

MEROPSiP02.009.
GPCRDBiSearch...

PTM databases

iPTMnetiO95490.
PhosphoSitePlusiO95490.

Polymorphism and mutation databases

BioMutaiLPHN2.

Proteomic databases

EPDiO95490.
MaxQBiO95490.
PaxDbiO95490.
PeptideAtlasiO95490.
PRIDEiO95490.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319517; ENSP00000322270; ENSG00000117114. [O95490-2]
ENST00000359929; ENSP00000353006; ENSG00000117114. [O95490-2]
ENST00000370713; ENSP00000359748; ENSG00000117114. [O95490-3]
ENST00000370715; ENSP00000359750; ENSG00000117114. [O95490-4]
ENST00000370717; ENSP00000359752; ENSG00000117114. [O95490-1]
ENST00000370723; ENSP00000359758; ENSG00000117114. [O95490-7]
ENST00000370725; ENSP00000359760; ENSG00000117114. [O95490-6]
ENST00000370728; ENSP00000359763; ENSG00000117114. [O95490-1]
ENST00000370730; ENSP00000359765; ENSG00000117114. [O95490-5]
GeneIDi23266.
KEGGihsa:23266.
UCSCiuc001dit.5. human. [O95490-1]

Organism-specific databases

CTDi23266.
DisGeNETi23266.
GeneCardsiADGRL2.
HGNCiHGNC:18582. ADGRL2.
HPAiHPA013573.
HPA043447.
MIMi607018. gene.
neXtProtiNX_O95490.
OpenTargetsiENSG00000117114.
PharmGKBiPA38589.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3545. Eukaryota.
KOG4193. Eukaryota.
KOG4729. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000049065.
HOVERGENiHBG052337.
InParanoidiO95490.
KOiK04593.
OMAiYFNANCS.
OrthoDBiEOG091G00GJ.
PhylomeDBiO95490.
TreeFamiTF351999.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117114-MONOMER.

Miscellaneous databases

ChiTaRSiLPHN2. human.
GeneWikiiLPHN2.
GenomeRNAii23266.
PROiO95490.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000117114.
CleanExiHS_LPHN2.
ExpressionAtlasiO95490. baseline and differential.
GenevisibleiO95490. HS.

Family and domain databases

InterProiIPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR031240. Latrophilin-2.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like_dom.
[Graphical view]
PANTHERiPTHR12011:SF61. PTHR12011:SF61. 2 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF16489. GAIN. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTiSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00284. OLF. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRL2_HUMAN
AccessioniPrimary (citable) accession number: O95490
Secondary accession number(s): A5XEI2
, B1ALT8, B1ALT9, B1ALU0, B1ALU2, B1ALU4, B1ALU5, B1ALU6, O94882, Q5VX76, Q9UKY5, Q9UKY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.