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O95490

- LPHN2_HUMAN

UniProt

O95490 - LPHN2_HUMAN

Protein

Latrophilin-2

Gene

LPHN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (26 Apr 2004)
      Previous versions | rss
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    Functioni

    Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei824 – 8252CleavageBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. G-protein coupled receptor activity Source: GDB
    3. latrotoxin receptor activity Source: UniProtKB

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: UniProtKB
    2. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Ligandi

    Lectin

    Protein family/group databases

    MEROPSiS63.012.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Latrophilin-2
    Alternative name(s):
    Calcium-independent alpha-latrotoxin receptor 2
    Short name:
    CIRL-2
    Latrophilin homolog 1
    Lectomedin-1
    Gene namesi
    Name:LPHN2
    Synonyms:KIAA0786, LEC1, LPHH1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:18582. LPHN2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38589.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 14591434Latrophilin-2PRO_0000012910Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi136 ↔ 318PROSITE-ProRule annotation
    Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi520 – 5201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi629 – 6291N-linked (GlcNAc...)1 Publication
    Glycosylationi731 – 7311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi744 – 7441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi787 – 7871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi792 – 7921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi813 – 8131N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1374 – 13741PhosphoserineBy similarity
    Modified residuei1430 – 14301Phosphoserine1 Publication

    Post-translational modificationi

    Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO95490.
    PaxDbiO95490.
    PRIDEiO95490.

    PTM databases

    PhosphoSiteiO95490.

    Expressioni

    Tissue specificityi

    Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others.1 Publication

    Gene expression databases

    ArrayExpressiO95490.
    BgeeiO95490.
    CleanExiHS_LPHN2.
    GenevestigatoriO95490.

    Organism-specific databases

    HPAiHPA013573.

    Interactioni

    Subunit structurei

    Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85).By similarity

    Protein-protein interaction databases

    BioGridi116868. 5 interactions.
    IntActiO95490. 3 interactions.
    MINTiMINT-143559.
    STRINGi9606.ENSP00000322270.

    Structurei

    3D structure databases

    ProteinModelPortaliO95490.
    SMRiO95490. Positions 30-132, 465-824, 849-1087.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini39 – 851813ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini873 – 8808CytoplasmicSequence Analysis
    Topological domaini902 – 9076ExtracellularSequence Analysis
    Topological domaini929 – 95224CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini974 – 99017ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1012 – 103726CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1059 – 10624ExtracellularSequence Analysis
    Topological domaini1084 – 1459376CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei852 – 87221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei881 – 90121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei908 – 92821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei953 – 97321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei991 – 101121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei1038 – 105821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei1063 – 108321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 13090SUEL-type lectinPROSITE-ProRule annotationAdd
    BLAST
    Domaini135 – 394260Olfactomedin-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini784 – 83653GPSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GPS domain.PROSITE-ProRule annotation
    Contains 1 olfactomedin-like domain.PROSITE-ProRule annotation
    Contains 1 SUEL-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253931.
    HOGENOMiHOG000049065.
    HOVERGENiHBG052337.
    KOiK04593.
    OMAiFQMENTD.
    PhylomeDBiO95490.
    TreeFamiTF351999.

    Family and domain databases

    InterProiIPR022624. DUF3497.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003924. GPCR_2_latrophilin.
    IPR003334. GPCR_2_latrophilin_rcpt_C.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR000922. Lectin_gal-bd_dom.
    IPR003112. Olfac-like.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF02140. Gal_Lectin. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF02354. Latrophilin. 1 hit.
    PF02191. OLF. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PR01444. LATROPHILIN.
    SMARTiSM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00284. OLF. 1 hit.
    [Graphical view]
    PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS51132. OLF. 1 hit.
    PS50228. SUEL_LECTIN. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95490-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVSSGCRMRS LWFIIVISFL PNTEGFSRAA LPFGLVRREL SCEGYSIDLR     50
    CPGSDVIMIE SANYGRTDDK ICDADPFQME NTDCYLPDAF KIMTQRCNNR 100
    TQCIVVTGSD VFPDPCPGTY KYLEVQYECV PYIFVCPGTL KAIVDSPCIY 150
    EAEQKAGAWC KDPLQAADKI YFMPWTPYRT DTLIEYASLE DFQNSRQTTT 200
    YKLPNRVDGT GFVVYDGAVF FNKERTRNIV KFDLRTRIKS GEAIINYANY 250
    HDTSPYRWGG KTDIDLAVDE NGLWVIYATE QNNGMIVISQ LNPYTLRFEA 300
    TWETVYDKRA ASNAFMICGV LYVVRSVYQD NESETGKNSI DYIYNTRLNR 350
    GEYVDVPFPN QYQYIAAVDY NPRDNQLYVW NNNFILRYSL EFGPPDPAQV 400
    PTTAVTITSS AELFKTIIST TSTTSQKGPM STTVAGSQEG SKGTKPPPAV 450
    STTKIPPITN IFPLPERFCE ALDSKGIKWP QTQRGMMVER PCPKGTRGTA 500
    SYLCMISTGT WNPKGPDLSN CTSHWVNQLA QKIRSGENAA SLANELAKHT 550
    KGPVFAGDVS SSVRLMEQLV DILDAQLQEL KPSEKDSAGR SYNKLQKREK 600
    TCRAYLKAIV DTVDNLLRPE ALESWKHMNS SEQAHTATML LDTLEEGAFV 650
    LADNLLEPTR VSMPTENIVL EVAVLSTEGQ IQDFKFPLGI KGAGSSIQLS 700
    ANTVKQNSRN GLAKLVFIIY RSLGQFLSTE NATIKLGADF IGRNSTIAVN 750
    SHVISVSINK ESSRVYLTDP VLFTLPHIDP DNYFNANCSF WNYSERTMMG 800
    YWSTQGCKLV DTNKTRTTCA CSHLTNFAIL MAHREIAYKD GVHELLLTVI 850
    TWVGIVISLV CLAICIFTFC FFRGLQSDRN TIHKNLCINL FIAEFIFLIG 900
    IDKTKYAIAC PIFAGLLHFF FLAAFAWMCL EGVQLYLMLV EVFESEYSRK 950
    KYYYVAGYLF PATVVGVSAA IDYKSYGTEK ACWLHVDNYF IWSFIGPVTF 1000
    IILLNIIFLV ITLCKMVKHS NTLKPDSSRL ENIKSWVLGA FALLCLLGLT 1050
    WSFGLLFINE ETIVMAYLFT IFNAFQGVFI FIFHCALQKK VRKEYGKCFR 1100
    HSYCCGGLPT ESPHSSVKAS TTRTSARYSS GTQSRIRRMW NDTVRKQSES 1150
    SFISGDINST STLNQGMTGN YLLTNPLLRP HGTNNPYNTL LAETVVCNAP 1200
    SAPVFNSPGH SLNNARDTSA MDTLPLNGNF NNSYSLHKGD YNDSVQVVDC 1250
    GLSLNDTAFE KMIISELVHN NLRGSSKTHN LELTLPVKPV IGGSSSEDDA 1300
    IVADASSLMH SDNPGLELHH KELEAPLIPQ RTHSLLYQPQ KKVKSEGTDS 1350
    YVSQLTAEAE DHLQSPNRDS LYTSMPNLRD SPYPESSPDM EEDLSPSRRS 1400
    ENEDIYYKSM PNLGAGHQLQ MCYQISRGNS DGYIIPINKE GCIPEGDVRE 1450
    GQMQLVTSL 1459
    Length:1,459
    Mass (Da):163,349
    Last modified:April 26, 2004 - v2
    Checksum:i30707B7C3C069029
    GO
    Isoform 2 (identifier: O95490-2) [UniParc]FASTAAdd to Basket

    Also known as: Lectomedin-1 gamma

    The sequence of this isoform differs from the canonical sequence as follows:
         595-607: Missing.
         1167-1209: Missing.

    Show »
    Length:1,403
    Mass (Da):157,178
    Checksum:iCE43AB82916D0D35
    GO
    Isoform 3 (identifier: O95490-3) [UniParc]FASTAAdd to Basket

    Also known as: Lectomedin-1 beta

    The sequence of this isoform differs from the canonical sequence as follows:
         595-607: Missing.
         1134-1136: SRI → DIH
         1137-1459: Missing.

    Show »
    Length:1,123
    Mass (Da):126,163
    Checksum:i21DB98B51EBDF4EC
    GO
    Isoform 4 (identifier: O95490-4) [UniParc]FASTAAdd to Basket

    Also known as: Lectomedin-1 alpha

    The sequence of this isoform differs from the canonical sequence as follows:
         595-607: Missing.
         1167-1209: Missing.
         1210-1233: HSLNNARDTSAMDTLPLNGNFNNS → LTSHGLRAHLQDLYHLELLLGQIA
         1234-1459: Missing.

    Show »
    Length:1,177
    Mass (Da):132,245
    Checksum:i6D099178841E1E3A
    GO
    Isoform 5 (identifier: O95490-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1167-1209: Missing.

    Note: No experimental confirmation.

    Show »
    Length:1,416
    Mass (Da):158,797
    Checksum:iFB5C1C0A9A9ED3C5
    GO
    Isoform 6 (identifier: O95490-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1034-1034: K → NNYRVCDGYYNTDLPG

    Show »
    Length:1,474
    Mass (Da):165,067
    Checksum:iA78543DA2A149746
    GO
    Isoform 7 (identifier: O95490-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         595-607: Missing.
         1034-1034: K → NNYRVCDGYYNTDLPG

    Note: No experimental confirmation.

    Show »
    Length:1,461
    Mass (Da):163,448
    Checksum:iB528698BA07BBC46
    GO

    Sequence cautioni

    The sequence CAI22406.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1059 – 10591N → S in ABL59902. (PubMed:17456239)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei595 – 60713Missing in isoform 2, isoform 3, isoform 4 and isoform 7. 2 PublicationsVSP_010104Add
    BLAST
    Alternative sequencei1034 – 10341K → NNYRVCDGYYNTDLPG in isoform 6 and isoform 7. 1 PublicationVSP_042267
    Alternative sequencei1134 – 11363SRI → DIH in isoform 3. 1 PublicationVSP_010105
    Alternative sequencei1137 – 1459323Missing in isoform 3. 1 PublicationVSP_010106Add
    BLAST
    Alternative sequencei1167 – 120943Missing in isoform 2, isoform 4 and isoform 5. 2 PublicationsVSP_010107Add
    BLAST
    Alternative sequencei1210 – 123324HSLNN…NFNNS → LTSHGLRAHLQDLYHLELLL GQIA in isoform 4. 1 PublicationVSP_010108Add
    BLAST
    Alternative sequencei1234 – 1459226Missing in isoform 4. 1 PublicationVSP_010109Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ131581 mRNA. Translation: CAA10458.1.
    AJ244492
    , AJ244493, AJ244494, AJ244496, AJ244497, AJ244498, AJ244499, AJ244501, AJ244502, AJ244503, AJ244504, AJ244505, AJ244506, AJ244507, AJ244510, AJ244511, AJ244512, AJ244516 Genomic DNA. Translation: CAB60229.1.
    AF104266 mRNA. Translation: AAD54675.1.
    AF104938 mRNA. Translation: AAD54676.1.
    AF104939 mRNA. Translation: AAD54677.1.
    AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71340.1.
    AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71341.1.
    AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71342.1.
    AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71343.1.
    AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71345.1.
    AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71346.1.
    AL359705, AC113949, AL157903 Genomic DNA. Translation: CAH71347.1.
    AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22397.1.
    AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22398.1.
    AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22399.1.
    AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22401.1.
    AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22402.1.
    AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22403.1.
    AL157903, AC113949, AL359705 Genomic DNA. Translation: CAI22405.1.
    AL157903, AC113949 Genomic DNA. Translation: CAI22406.1. Sequence problems.
    CH471059 Genomic DNA. Translation: EAX06327.1.
    CH471059 Genomic DNA. Translation: EAX06330.1.
    CH471059 Genomic DNA. Translation: EAX06333.1.
    CH471059 Genomic DNA. Translation: EAX06335.1.
    CH471059 Genomic DNA. Translation: EAX06336.1.
    CH471059 Genomic DNA. Translation: EAX06339.1.
    AB018329 mRNA. Translation: BAA34506.1.
    DQ925675 mRNA. Translation: ABL59902.1.
    CCDSiCCDS689.1. [O95490-2]
    RefSeqiNP_036434.1. NM_012302.2. [O95490-2]
    XP_005270723.1. XM_005270666.2. [O95490-1]
    XP_005270727.1. XM_005270670.2. [O95490-2]
    XP_005270730.1. XM_005270673.2. [O95490-4]
    XP_005270731.1. XM_005270674.2. [O95490-4]
    XP_006710555.1. XM_006710492.1. [O95490-2]
    UniGeneiHs.24212.
    Hs.649282.

    Genome annotation databases

    EnsembliENST00000319517; ENSP00000322270; ENSG00000117114. [O95490-2]
    ENST00000359929; ENSP00000353006; ENSG00000117114. [O95490-2]
    ENST00000370713; ENSP00000359748; ENSG00000117114. [O95490-3]
    ENST00000370715; ENSP00000359750; ENSG00000117114. [O95490-4]
    ENST00000370717; ENSP00000359752; ENSG00000117114. [O95490-6]
    ENST00000370723; ENSP00000359758; ENSG00000117114. [O95490-7]
    ENST00000370725; ENSP00000359760; ENSG00000117114. [O95490-6]
    ENST00000370728; ENSP00000359763; ENSG00000117114. [O95490-1]
    ENST00000370730; ENSP00000359765; ENSG00000117114. [O95490-5]
    GeneIDi23266.
    KEGGihsa:23266.
    UCSCiuc001dit.4. human. [O95490-2]
    uc001div.3. human. [O95490-4]
    uc001diw.3. human. [O95490-1]
    uc009wcd.3. human. [O95490-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ131581 mRNA. Translation: CAA10458.1 .
    AJ244492
    , AJ244493 , AJ244494 , AJ244496 , AJ244497 , AJ244498 , AJ244499 , AJ244501 , AJ244502 , AJ244503 , AJ244504 , AJ244505 , AJ244506 , AJ244507 , AJ244510 , AJ244511 , AJ244512 , AJ244516 Genomic DNA. Translation: CAB60229.1 .
    AF104266 mRNA. Translation: AAD54675.1 .
    AF104938 mRNA. Translation: AAD54676.1 .
    AF104939 mRNA. Translation: AAD54677.1 .
    AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71340.1 .
    AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71341.1 .
    AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71342.1 .
    AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71343.1 .
    AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71345.1 .
    AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71346.1 .
    AL359705 , AC113949 , AL157903 Genomic DNA. Translation: CAH71347.1 .
    AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22397.1 .
    AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22398.1 .
    AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22399.1 .
    AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22401.1 .
    AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22402.1 .
    AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22403.1 .
    AL157903 , AC113949 , AL359705 Genomic DNA. Translation: CAI22405.1 .
    AL157903 , AC113949 Genomic DNA. Translation: CAI22406.1 . Sequence problems.
    CH471059 Genomic DNA. Translation: EAX06327.1 .
    CH471059 Genomic DNA. Translation: EAX06330.1 .
    CH471059 Genomic DNA. Translation: EAX06333.1 .
    CH471059 Genomic DNA. Translation: EAX06335.1 .
    CH471059 Genomic DNA. Translation: EAX06336.1 .
    CH471059 Genomic DNA. Translation: EAX06339.1 .
    AB018329 mRNA. Translation: BAA34506.1 .
    DQ925675 mRNA. Translation: ABL59902.1 .
    CCDSi CCDS689.1. [O95490-2 ]
    RefSeqi NP_036434.1. NM_012302.2. [O95490-2 ]
    XP_005270723.1. XM_005270666.2. [O95490-1 ]
    XP_005270727.1. XM_005270670.2. [O95490-2 ]
    XP_005270730.1. XM_005270673.2. [O95490-4 ]
    XP_005270731.1. XM_005270674.2. [O95490-4 ]
    XP_006710555.1. XM_006710492.1. [O95490-2 ]
    UniGenei Hs.24212.
    Hs.649282.

    3D structure databases

    ProteinModelPortali O95490.
    SMRi O95490. Positions 30-132, 465-824, 849-1087.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116868. 5 interactions.
    IntActi O95490. 3 interactions.
    MINTi MINT-143559.
    STRINGi 9606.ENSP00000322270.

    Protein family/group databases

    MEROPSi S63.012.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei O95490.

    Proteomic databases

    MaxQBi O95490.
    PaxDbi O95490.
    PRIDEi O95490.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000319517 ; ENSP00000322270 ; ENSG00000117114 . [O95490-2 ]
    ENST00000359929 ; ENSP00000353006 ; ENSG00000117114 . [O95490-2 ]
    ENST00000370713 ; ENSP00000359748 ; ENSG00000117114 . [O95490-3 ]
    ENST00000370715 ; ENSP00000359750 ; ENSG00000117114 . [O95490-4 ]
    ENST00000370717 ; ENSP00000359752 ; ENSG00000117114 . [O95490-6 ]
    ENST00000370723 ; ENSP00000359758 ; ENSG00000117114 . [O95490-7 ]
    ENST00000370725 ; ENSP00000359760 ; ENSG00000117114 . [O95490-6 ]
    ENST00000370728 ; ENSP00000359763 ; ENSG00000117114 . [O95490-1 ]
    ENST00000370730 ; ENSP00000359765 ; ENSG00000117114 . [O95490-5 ]
    GeneIDi 23266.
    KEGGi hsa:23266.
    UCSCi uc001dit.4. human. [O95490-2 ]
    uc001div.3. human. [O95490-4 ]
    uc001diw.3. human. [O95490-1 ]
    uc009wcd.3. human. [O95490-3 ]

    Organism-specific databases

    CTDi 23266.
    GeneCardsi GC01P081771.
    HGNCi HGNC:18582. LPHN2.
    HPAi HPA013573.
    MIMi 607018. gene.
    neXtProti NX_O95490.
    PharmGKBi PA38589.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253931.
    HOGENOMi HOG000049065.
    HOVERGENi HBG052337.
    KOi K04593.
    OMAi FQMENTD.
    PhylomeDBi O95490.
    TreeFami TF351999.

    Miscellaneous databases

    ChiTaRSi LPHN2. human.
    GeneWikii LPHN2.
    GenomeRNAii 23266.
    NextBioi 45018.
    PROi O95490.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95490.
    Bgeei O95490.
    CleanExi HS_LPHN2.
    Genevestigatori O95490.

    Family and domain databases

    InterProi IPR022624. DUF3497.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003924. GPCR_2_latrophilin.
    IPR003334. GPCR_2_latrophilin_rcpt_C.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR000922. Lectin_gal-bd_dom.
    IPR003112. Olfac-like.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF02140. Gal_Lectin. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF02354. Latrophilin. 1 hit.
    PF02191. OLF. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PR01444. LATROPHILIN.
    SMARTi SM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00284. OLF. 1 hit.
    [Graphical view ]
    PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS51132. OLF. 1 hit.
    PS50228. SUEL_LECTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterisation of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer."
      White G.R.M., Varley J.M., Heighway J.
      Oncogene 17:3513-3519(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    2. "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines."
      White G.R.M., Varley J.M., Heighway J.
      Biochim. Biophys. Acta 1491:75-92(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Hayflick J.S.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4).
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 439-1459 (ISOFORM 1).
      Tissue: Brain.
    7. "Discovery of tissue-specific exons using comprehensive human exon microarrays."
      Clark T.A., Schweitzer A.C., Chen T.X., Staples M.K., Lu G., Wang H., Williams A., Blume J.E.
      Genome Biol. 8:R64.1-R64.16(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 973-1070 (ISOFORM 6).
    8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-629.
      Tissue: Liver.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1430, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLPHN2_HUMAN
    AccessioniPrimary (citable) accession number: O95490
    Secondary accession number(s): A5XEI2
    , B1ALT8, B1ALT9, B1ALU0, B1ALU2, B1ALU4, B1ALU5, B1ALU6, O94882, Q5VX76, Q9UKY5, Q9UKY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: April 26, 2004
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3