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Reviewed, UniProtKB/Swiss-Prot O95487 (SC24B_HUMAN)

Last modified November 24, 2009. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Protein transport protein Sec24B
Alternative name(s):
    SEC24-related protein B
Gene names
Name: SEC24B
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1268 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.

Subunit structure

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Sec24B is capable of forming heterodimers with Sec24A.

Subcellular location

Cytoplasm. Cytoplasmperinuclear region. Endoplasmic reticulum membrane Potential. Golgi apparatus membrane Potential. Golgi apparatus membrane By similarity.

Tissue specificity

Expressed in fibroblasts, hepatocytes, and lymphocytes.

Sequence similarities

Belongs to the SEC23/SEC24 family. SEC24 subfamily.

Sequence caution

The sequence CAA10335.1 differs from that shown. Reason: Frameshift at positions 459 and 483.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PLCG1P191741EBI-81101,EBI-79387
SEC23AQ154361EBI-81101,EBI-81088

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O95487-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O95487-2)

The sequence of this isoform differs from the canonical sequence as follows:
     354-388: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12681268Protein transport protein Sec24B
PRO_0000205155

Regions

Region605 – 62925Zinc finger-like
Compositional bias379 – 3879Poly-Glu

Amino acid modifications

Modified residue1171Phosphotyrosine Ref.4
Modified residue11001Phosphotyrosine Ref.6
Modified residue12241Phosphoserine Ref.4 Ref.5

Natural variations

Alternative sequence354 – 38835Missing in isoform 2.
VSP_035987
Natural variant4561A → G: dbSNP rs35705351.
VAR_047934

Experimental info

Sequence conflict231A → S in CAA10335. Ref.1

Secondary structure

................................................................................................................................ 1268
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: 0E08B982D0982F84

FASTA1,268137,418
        10         20         30         40         50         60 
MSAPAGSSHP AASARIPPKF GGAAVSGAAA PAGPGAGPAP HQQNGPAQNQ MQVPSGYGLH 

        70         80         90        100        110        120 
HQNYIAPSGH YSQGPGKMTS LPLDTQCGDY YSALYTVPTQ NVTPNTVNQQ PGAQQLYSRG 

       130        140        150        160        170        180 
PPAPHIVGST LGSFQGAASS ASHLHTSASQ PYSSFVNHYN SPAMYSASSS VASQGFPSTC 

       190        200        210        220        230        240 
GHYAMSTVSN AAYPSVSYPS LPAGDTYGQM FTSQNAPTVR PVKDNSFSGQ NTAISHPSPL 

       250        260        270        280        290        300 
PPLPSQQHHQ QQSLSGYSTL TWSSPGLPST QDNLIRNHTG SLAVANNNPT ITVADSLSCP 

       310        320        330        340        350        360 
VMQNVQPPKS SPVVSTVLSG SSGSSSTRTP PTANHPVEPV TSVTQPSELL QQKGVQYGEY 

       370        380        390        400        410        420 
VNNQASSAPT PLSSTSDDEE EEEEDEEAGV DSSSTTSSAS PMPNSYDALE GGSYPDMLSS 

       430        440        450        460        470        480 
SASSPAPDPA PEPDPASAPA PASAPAPVVP QPSKMAKPFG YGYPTLQPGY QNATAPLISG 

       490        500        510        520        530        540 
VQPSNPVYSG FQQYPQQYPG VNQLSSSIGG LSLQSSPQPE SLRPVNLTQE RNILPMTPVW 

       550        560        570        580        590        600 
APVPNLNADL KKLNCSPDSF RCTLTNIPQT QALLNKAKLP LGLLLHPFRD LTQLPVITSN 

       610        620        630        640        650        660 
TIVRCRSCRT YINPFVSFID QRRWKCNLCY RVNDVPEEFM YNPLTRSYGE PHKRPEVQNS 

       670        680        690        700        710        720 
TVEFIASSDY MLRPPQPAVY LFVLDVSHNA VEAGYLTILC QSLLENLDKL PGDSRTRIGF 

       730        740        750        760        770        780 
MTFDSTIHFY NLQEGLSQPQ MLIVSDIDDV FLPTPDSLLV NLYESKELIK DLLNALPNMF 

       790        800        810        820        830        840 
TNTRETHSAL GPALQAAFKL MSPTGGRVSV FQTQLPSLGA GLLQSREDPN QRSSTKVVQH 

       850        860        870        880        890        900 
LGPATDFYKK LALDCSGQQT AVDLFLLSSQ YSDLASLACM SKYSAGCIYY YPSFHYTHNP 

       910        920        930        940        950        960 
SQAEKLQKDL KRYLTRKIGF EAVMRIRCTK GLSMHTFHGN FFVRSTDLLS LANINPDAGF 

       970        980        990       1000       1010       1020 
AVQLSIEESL TDTSLVCFQT ALLYTSSKGE RRIRVHTLCL PVVSSLADVY AGVDVQAAIC 

      1030       1040       1050       1060       1070       1080 
LLANMAVDRS VSSSLSDARD ALVNAVVDSL SAYGSTVSNL QHSALMAPSS LKLFPLYVLA 

      1090       1100       1110       1120       1130       1140 
LLKQKAFRTG TSTRLDDRVY AMCQIKSQPL VHLMKMIHPN LYRIDRLTDE GAVHVNDRIV 

      1150       1160       1170       1180       1190       1200 
PQPPLQKLSA EKLTREGAFL MDCGSVFYIW VGKGCDNNFI EDVLGYTNFA SIPQKMTHLP 

      1210       1220       1230       1240       1250       1260 
ELDTLSSERA RSFITWLRDS RPLSPILHIV KDESPAKAEF FQHLIEDRTE AAFSYYEFLL 


HVQQQICK 

« Hide

Isoform 2.

Checksum: 95EEBB976F613B6B
Show »

FASTA1,233133,629

References

« Hide 'large scale' references
[1]"Sec24 proteins and sorting at the endoplasmic reticulum."
Pagano A., Letourneur F., Garcia-Estefania D., Carpentier J.-L., Orci L., Paccaud J.-P.
J. Biol. Chem. 274:7833-7840(1999) [PubMed: 10075675] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: B-cell.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed: 15815621] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[4]"Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry."
Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J., Bodenmiller B., Watts J.D., Hood L., Aebersold R.
Nat. Methods 2:591-598(2005) [PubMed: 16094384] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-117 AND SER-1224, MASS SPECTROMETRY.
Tissue: T-cell.
[5]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1224, MASS SPECTROMETRY.
Tissue: Epithelium.
[6]"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer."
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. expand/collapse author list , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.
Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1100, MASS SPECTROMETRY.
[7]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

AJ131245 mRNA. Translation: CAA10335.1. Frameshift.
AC105314 Genomic DNA. No translation available.
AC138782 Genomic DNA. No translation available.
BC117135 mRNA. Translation: AAI17136.1.
BC143276 mRNA. Translation: AAI43277.1.
IPIIPI00785208.
IPI00946469.
RefSeqNP_001036199.1.
NP_006314.2.
UniGeneHs.292472

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
3EH1X-ray1.80A518-1268[»]
ModBaseSearch...

Protein-protein interaction databases

IntActO95487. 2 interactions.
STRINGO95487.

PTM databases

PhosphoSiteO95487.

Proteomic databases

PRIDEO95487.

Genome annotation databases

EnsemblENST00000265175; ENSP00000265175; ENSG00000138802; Homo sapiens. [Genome view]
ENST00000399100; ENSP00000382051; ENSG00000138802; Homo sapiens. [Genome view]
GeneID10427.
KEGGhsa:10427.

Organism-specific databases

CTD10427.
GeneCardsGC04P110574.
H-InvDBHIX0031396.
HGNCHGNC:10704. SEC24B.
MIM607184. gene.
PharmGKBPA35627.
GenAtlasSearch...

Phylogenomic databases

HOGENOMO95487.
HOVERGENO95487.
OMAQGFPSTC
OrthoDBEOG9ZCWQ1

Enzyme and pathway databases

ReactomeREACT_11123. Membrane Trafficking.

Gene expression databases

ArrayExpressO95487.
BgeeO95487.
CleanExHS_SEC24B.
GenevestigatorO95487.

Family and domain databases

InterProIPR007123. Gelsoln.
IPR012990. Sec23_24_beta_S.
IPR006900. Sec23_helical.
IPR006896. Sec23_trunk.
IPR006895. Znf_Sec23_Sec24.
[Graphical view]
PfamPF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

Entry information

Entry nameSC24B_HUMAN
AccessionPrimary (citable) accession number: O95487
Secondary accession number(s): B7ZKN4, Q0VG08
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: December 16, 2008
Last modified: November 24, 2009
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Human chromosome 4: entries, gene names and cross-references to MIM

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List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents