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O95486 (SC24A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein transport protein Sec24A
Alternative name(s):
SEC24-related protein A
Gene names
Name:SEC24A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1093 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.

Subunit structure

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. SEC24A is capable of forming heterodimers with SEC24B and SEC24C. Interacts with TMED2. Ref.4

Subcellular location

Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Endoplasmic reticulum membrane By similarity. Golgi apparatus membrane By similarity.

Tissue specificity

Expressed in fibroblasts, hepatocytes, and lymphocytes.

Sequence similarities

Belongs to the SEC23/SEC24 family. SEC24 subfamily.

Sequence caution

The sequence CAA10334.1 differs from that shown. Reason: Frameshift at position 68.

Ontologies

Keywords
   Biological processER-Golgi transport
Protein transport
Transport
   Cellular componentCytoplasm
Endoplasmic reticulum
Golgi apparatus
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processCOPII vesicle coating

Traceable author statement. Source: Reactome

ER to Golgi vesicle-mediated transport

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class II

Traceable author statement. Source: Reactome

antigen processing and presentation of peptide antigen via MHC class I

Traceable author statement. Source: Reactome

cellular protein metabolic process

Traceable author statement. Source: Reactome

intracellular protein transport

Inferred from electronic annotation. Source: InterPro

membrane organization

Traceable author statement. Source: Reactome

post-translational protein modification

Traceable author statement. Source: Reactome

protein N-linked glycosylation via asparagine

Traceable author statement. Source: Reactome

small molecule metabolic process

Traceable author statement. Source: Reactome

   Cellular_componentCOPII vesicle coat

Inferred from electronic annotation. Source: InterPro

ER to Golgi transport vesicle membrane

Traceable author statement. Source: Reactome

Golgi membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytosol

Traceable author statement. Source: Reactome

endoplasmic reticulum membrane

Traceable author statement. Source: Reactome

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O95486-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O95486-2)

The sequence of this isoform differs from the canonical sequence as follows:
     594-613: LVQDLLKTLPQMFTKTLETQ → SVIGVSSEETLITCLEIAMR
     614-1093: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10931093Protein transport protein Sec24A
PRO_0000205153

Regions

Region431 – 45525Zinc finger-like
Compositional bias89 – 237149Pro-rich

Natural variations

Alternative sequence594 – 61320LVQDL…TLETQ → SVIGVSSEETLITCLEIAMR in isoform 2.
VSP_029571
Alternative sequence614 – 1093480Missing in isoform 2.
VSP_029572
Natural variant2611S → G.
Corresponds to variant rs7718102 [ dbSNP | Ensembl ].
VAR_037253
Natural variant3021T → I. Ref.2
Corresponds to variant rs17851746 [ dbSNP | Ensembl ].
VAR_037254
Natural variant3961T → M. Ref.2
Corresponds to variant rs17851745 [ dbSNP | Ensembl ].
VAR_037255

Secondary structure

................................................................................................................................ 1093
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: E21F3A1333674A6A

FASTA1,093119,749
        10         20         30         40         50         60 
MSQPGIPASG GAPASLQAQN GAALASGSPY TNGPVQNALL SSQESVSQGY NFQLPGSYPH 

        70         80         90        100        110        120 
PIPAKTLNPV SGQSNYGGSQ GSGQTLNRPP VASNPVTPSL HSGPAPRMPL PASQNPATTP 

       130        140        150        160        170        180 
MPSSSFLPEA NLPPPLNWQY NYPSTASQTN HCPRASSQPT VSGNTSLTTN HQYVSSGYPS 

       190        200        210        220        230        240 
LQNSFIKSGP SVPPLVNPPL PTTFQPGAPH GPPPAGGPPP VRALTPLTSS YRDVPQPLFN 

       250        260        270        280        290        300 
SAVNQEGITS NTNNGSMVVH SSYDEIEGGG LLATPQLTNK NPKMSRSVGY SYPSLPPGYQ 

       310        320        330        340        350        360 
NTTPPGATGV PPSSLNYPSG PQAFTQTPLG ANHLTTSMSG LSLQPEGLRV VNLLQERNML 

       370        380        390        400        410        420 
PSTPLKPPVP NLHEDIQKLN CNPELFRCTL TSIPQTQALL NKAKLPLGLL LHPFKDLVQL 

       430        440        450        460        470        480 
PVVTSSTIVR CRSCRTYINP FVSFLDQRRW KCNLCYRVND VPEEFLYNPL TRVYGEPHRR 

       490        500        510        520        530        540 
PEVQNATIEF MAPSEYMLRP PQPPVYLFVF DVSHNAVETG YLNSVCQSLL DNLDLLPGNT 

       550        560        570        580        590        600 
RTKIGFITFD STIHFYGLQE SLSQPQMLIV SDIEDVFIPM PENLLVNLNE SKELVQDLLK 

       610        620        630        640        650        660 
TLPQMFTKTL ETQSALGPAL QAAFKLMSPT GGRMSVFQTQ LPTLGVGALK PREEPNHRSS 

       670        680        690        700        710        720 
AKDIHMTPST DFYKKLALDC SGQQVAVDLF LLSGQYSDLA SLGCISRYSA GSVYYYPSYH 

       730        740        750        760        770        780 
HQHNPVQVQK LQKELQRYLT RKIGFEAVMR IRCTKGLSIH TFHGNFFVRS TDLLSLPNVN 

       790        800        810        820        830        840 
PDAGYAVQMS VEESLTDTQL VSFQSALLYT SSKGERRIRV HTLCLPVVST LNDVFLGADV 

       850        860        870        880        890        900 
QAISGLLANM AVDRSMTASL SDARDALVNA VIDSLSAYRS SVLSNQQPGL MVPFSLRLFP 

       910        920        930        940        950        960 
LFVLALLKQK SFQTGTNARL DERIFAMCQV KNQPLVYLML TTHPSLYRVD NLSDEGALNI 

       970        980        990       1000       1010       1020 
SDRTIPQPPI LQLSVEKLSR DGAFLMDAGS VLMLWVGKNC TQNFLSQVLG VQNYASIPQP 

      1030       1040       1050       1060       1070       1080 
MTDLPELDTP ESARIIAFIS WLREQRPFFP ILYVIRDESP MKANFLQNMI EDRTESALSY 

      1090 
YEFLLHIQQQ VNK 

« Hide

Isoform 2 [UniParc].

Checksum: 9D80E2297AC131C0
Show »

FASTA61366,010

References

« Hide 'large scale' references
[1]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 690-1093 (ISOFORM 1), VARIANTS ILE-302 AND MET-396.
Tissue: Brain and Eye.
[3]"Sec24 proteins and sorting at the endoplasmic reticulum."
Pagano A., Letourneur F., Garcia-Estefania D., Carpentier J.-L., Orci L., Paccaud J.-P.
J. Biol. Chem. 274:7833-7840(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-1093 (ISOFORM 1).
Tissue: B-cell.
[4]"Selective export of human GPI-anchored proteins from the endoplasmic reticulum."
Bonnon C., Wendeler M.W., Paccaud J.P., Hauri H.P.
J. Cell Sci. 123:1705-1715(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TMED2.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Web resources

Wikipedia

COPII entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH471062 Genomic DNA. Translation: EAW62246.1.
BC009325 mRNA. Translation: AAH09325.2.
BC019341 mRNA. Translation: AAH19341.1.
AJ131244 mRNA. Translation: CAA10334.1. Frameshift.
RefSeqNP_001239160.1. NM_001252231.1.
NP_068817.1. NM_021982.2.
XP_005271911.1. XM_005271854.1.
UniGeneHs.595540.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2NUPX-ray2.80B341-1078[»]
2NUTX-ray2.30B341-1078[»]
3EGDX-ray2.70B346-1093[»]
3EGXX-ray3.30B346-1093[»]
ProteinModelPortalO95486.
SMRO95486. Positions 346-1093.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116016. 46 interactions.
IntActO95486. 5 interactions.
MINTMINT-1479845.
STRING9606.ENSP00000381823.

PTM databases

PhosphoSiteO95486.

Proteomic databases

PaxDbO95486.
PRIDEO95486.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000322887; ENSP00000321749; ENSG00000113615. [O95486-2]
ENST00000398844; ENSP00000381823; ENSG00000113615. [O95486-1]
GeneID10802.
KEGGhsa:10802.
UCSCuc003kzs.3. human. [O95486-1]
uc021ydr.1. human. [O95486-2]

Organism-specific databases

CTD10802.
GeneCardsGC05P134011.
H-InvDBHIX0005186.
HGNCHGNC:10703. SEC24A.
HPAHPA038901.
MIM607183. gene.
neXtProtNX_O95486.
PharmGKBPA35626.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5028.
HOGENOMHOG000196365.
HOVERGENHBG054850.
InParanoidO95486.
KOK14007.
OMAFAHEFGE.
OrthoDBEOG7R56RS.
PhylomeDBO95486.
TreeFamTF350406.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_11123. Membrane Trafficking.
REACT_17015. Metabolism of proteins.
REACT_6900. Immune System.

Gene expression databases

BgeeO95486.
CleanExHS_SEC24A.
GenevestigatorO95486.

Family and domain databases

Gene3D3.40.50.410. 1 hit.
InterProIPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
[Graphical view]
PfamPF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
[Graphical view]
SUPFAMSSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSEC24A. human.
EvolutionaryTraceO95486.
GenomeRNAi10802.
NextBio41025.
PROO95486.
SOURCESearch...

Entry information

Entry nameSC24A_HUMAN
AccessionPrimary (citable) accession number: O95486
Secondary accession number(s): A8MVW3, Q8WUV2, Q96GP7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 13, 2007
Last modified: April 16, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM