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O95486

- SC24A_HUMAN

UniProt

O95486 - SC24A_HUMAN

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Protein

Protein transport protein Sec24A

Gene

SEC24A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  2. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  3. cellular protein metabolic process Source: Reactome
  4. COPII vesicle coating Source: Reactome
  5. ER to Golgi vesicle-mediated transport Source: Reactome
  6. intracellular protein transport Source: InterPro
  7. membrane organization Source: Reactome
  8. positive regulation of cholesterol homeostasis Source: Ensembl
  9. positive regulation of protein secretion Source: Ensembl
  10. post-translational protein modification Source: Reactome
  11. protein N-linked glycosylation via asparagine Source: Reactome
  12. regulation of low-density lipoprotein particle receptor biosynthetic process Source: Ensembl
  13. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_12507. COPII (Coat Protein 2) Mediated Vesicle Transport.
REACT_147797. Regulation of cholesterol biosynthesis by SREBP (SREBF).
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec24A
Alternative name(s):
SEC24-related protein A
Gene namesi
Name:SEC24A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:10703. SEC24A.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Endoplasmic reticulum membrane By similarity. Golgi apparatus membrane By similarity

GO - Cellular componenti

  1. COPII vesicle coat Source: InterPro
  2. cytosol Source: Reactome
  3. endoplasmic reticulum membrane Source: Reactome
  4. ER to Golgi transport vesicle membrane Source: Reactome
  5. Golgi membrane Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35626.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10931093Protein transport protein Sec24APRO_0000205153Add
BLAST

Proteomic databases

MaxQBiO95486.
PaxDbiO95486.
PRIDEiO95486.

PTM databases

PhosphoSiteiO95486.

Expressioni

Tissue specificityi

Expressed in fibroblasts, hepatocytes, and lymphocytes.

Gene expression databases

BgeeiO95486.
CleanExiHS_SEC24A.
GenevestigatoriO95486.

Organism-specific databases

HPAiHPA038901.

Interactioni

Subunit structurei

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. SEC24A is capable of forming heterodimers with SEC24B and SEC24C. Interacts with TMED2.1 Publication

Protein-protein interaction databases

BioGridi116016. 48 interactions.
IntActiO95486. 5 interactions.
MINTiMINT-1479845.
STRINGi9606.ENSP00000381823.

Structurei

Secondary structure

1
1093
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi350 – 3523Combined sources
Helixi353 – 3564Combined sources
Helixi374 – 3774Combined sources
Turni383 – 3853Combined sources
Beta strandi386 – 39611Combined sources
Helixi397 – 4037Combined sources
Beta strandi408 – 4114Combined sources
Turni432 – 4343Combined sources
Beta strandi442 – 45110Combined sources
Turni453 – 4553Combined sources
Beta strandi458 – 4603Combined sources
Helixi477 – 4793Combined sources
Helixi481 – 4844Combined sources
Beta strandi486 – 4916Combined sources
Helixi494 – 4963Combined sources
Beta strandi498 – 5003Combined sources
Beta strandi505 – 5117Combined sources
Helixi514 – 5196Combined sources
Helixi521 – 53212Combined sources
Turni533 – 5353Combined sources
Beta strandi543 – 55715Combined sources
Beta strandi562 – 5643Combined sources
Beta strandi566 – 5705Combined sources
Beta strandi581 – 5877Combined sources
Turni588 – 5914Combined sources
Helixi592 – 60110Combined sources
Helixi602 – 6043Combined sources
Turni605 – 6084Combined sources
Helixi616 – 62712Combined sources
Turni628 – 6303Combined sources
Beta strandi632 – 6387Combined sources
Beta strandi657 – 6593Combined sources
Helixi672 – 68211Combined sources
Beta strandi685 – 6917Combined sources
Helixi699 – 7024Combined sources
Helixi704 – 7074Combined sources
Turni708 – 7103Combined sources
Beta strandi713 – 7153Combined sources
Turni721 – 7233Combined sources
Helixi725 – 74016Combined sources
Beta strandi744 – 75310Combined sources
Beta strandi757 – 76812Combined sources
Beta strandi770 – 7723Combined sources
Beta strandi774 – 7796Combined sources
Beta strandi785 – 7939Combined sources
Beta strandi799 – 81012Combined sources
Beta strandi816 – 82813Combined sources
Helixi831 – 8366Combined sources
Helixi840 – 85718Combined sources
Helixi860 – 87920Combined sources
Beta strandi891 – 8933Combined sources
Helixi894 – 8963Combined sources
Helixi899 – 90810Combined sources
Turni910 – 9123Combined sources
Helixi920 – 93213Combined sources
Helixi935 – 9428Combined sources
Beta strandi945 – 9484Combined sources
Beta strandi954 – 9563Combined sources
Turni975 – 9773Combined sources
Beta strandi982 – 9876Combined sources
Beta strandi989 – 9968Combined sources
Helixi1002 – 10076Combined sources
Helixi1014 – 10163Combined sources
Helixi1030 – 104314Combined sources
Beta strandi1046 – 10483Combined sources
Beta strandi1051 – 10533Combined sources
Beta strandi1058 – 10614Combined sources
Helixi1066 – 10683Combined sources
Helixi1080 – 109112Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NUPX-ray2.80B341-1093[»]
2NUTX-ray2.30B341-1093[»]
3EGDX-ray2.70B346-1093[»]
3EGXX-ray3.30B346-1093[»]
ProteinModelPortaliO95486.
SMRiO95486. Positions 346-1093.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95486.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni431 – 45525Zinc finger-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi89 – 237149Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC24 subfamily.Curated

Phylogenomic databases

eggNOGiCOG5028.
GeneTreeiENSGT00590000082962.
HOGENOMiHOG000196365.
HOVERGENiHBG054850.
InParanoidiO95486.
KOiK14007.
OMAiFAHEFGE.
OrthoDBiEOG7R56RS.
PhylomeDBiO95486.
TreeFamiTF350406.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
[Graphical view]
PfamiPF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95486-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQPGIPASG GAPASLQAQN GAALASGSPY TNGPVQNALL SSQESVSQGY
60 70 80 90 100
NFQLPGSYPH PIPAKTLNPV SGQSNYGGSQ GSGQTLNRPP VASNPVTPSL
110 120 130 140 150
HSGPAPRMPL PASQNPATTP MPSSSFLPEA NLPPPLNWQY NYPSTASQTN
160 170 180 190 200
HCPRASSQPT VSGNTSLTTN HQYVSSGYPS LQNSFIKSGP SVPPLVNPPL
210 220 230 240 250
PTTFQPGAPH GPPPAGGPPP VRALTPLTSS YRDVPQPLFN SAVNQEGITS
260 270 280 290 300
NTNNGSMVVH SSYDEIEGGG LLATPQLTNK NPKMSRSVGY SYPSLPPGYQ
310 320 330 340 350
NTTPPGATGV PPSSLNYPSG PQAFTQTPLG ANHLTTSMSG LSLQPEGLRV
360 370 380 390 400
VNLLQERNML PSTPLKPPVP NLHEDIQKLN CNPELFRCTL TSIPQTQALL
410 420 430 440 450
NKAKLPLGLL LHPFKDLVQL PVVTSSTIVR CRSCRTYINP FVSFLDQRRW
460 470 480 490 500
KCNLCYRVND VPEEFLYNPL TRVYGEPHRR PEVQNATIEF MAPSEYMLRP
510 520 530 540 550
PQPPVYLFVF DVSHNAVETG YLNSVCQSLL DNLDLLPGNT RTKIGFITFD
560 570 580 590 600
STIHFYGLQE SLSQPQMLIV SDIEDVFIPM PENLLVNLNE SKELVQDLLK
610 620 630 640 650
TLPQMFTKTL ETQSALGPAL QAAFKLMSPT GGRMSVFQTQ LPTLGVGALK
660 670 680 690 700
PREEPNHRSS AKDIHMTPST DFYKKLALDC SGQQVAVDLF LLSGQYSDLA
710 720 730 740 750
SLGCISRYSA GSVYYYPSYH HQHNPVQVQK LQKELQRYLT RKIGFEAVMR
760 770 780 790 800
IRCTKGLSIH TFHGNFFVRS TDLLSLPNVN PDAGYAVQMS VEESLTDTQL
810 820 830 840 850
VSFQSALLYT SSKGERRIRV HTLCLPVVST LNDVFLGADV QAISGLLANM
860 870 880 890 900
AVDRSMTASL SDARDALVNA VIDSLSAYRS SVLSNQQPGL MVPFSLRLFP
910 920 930 940 950
LFVLALLKQK SFQTGTNARL DERIFAMCQV KNQPLVYLML TTHPSLYRVD
960 970 980 990 1000
NLSDEGALNI SDRTIPQPPI LQLSVEKLSR DGAFLMDAGS VLMLWVGKNC
1010 1020 1030 1040 1050
TQNFLSQVLG VQNYASIPQP MTDLPELDTP ESARIIAFIS WLREQRPFFP
1060 1070 1080 1090
ILYVIRDESP MKANFLQNMI EDRTESALSY YEFLLHIQQQ VNK
Length:1,093
Mass (Da):119,749
Last modified:November 13, 2007 - v2
Checksum:iE21F3A1333674A6A
GO
Isoform 2 (identifier: O95486-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     594-613: LVQDLLKTLPQMFTKTLETQ → SVIGVSSEETLITCLEIAMR
     614-1093: Missing.

Note: No experimental confirmation available.

Show »
Length:613
Mass (Da):66,010
Checksum:i9D80E2297AC131C0
GO

Sequence cautioni

The sequence CAA10334.1 differs from that shown. Reason: Frameshift at position 68. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti261 – 2611S → G.
Corresponds to variant rs7718102 [ dbSNP | Ensembl ].
VAR_037253
Natural varianti302 – 3021T → I.1 Publication
Corresponds to variant rs17851746 [ dbSNP | Ensembl ].
VAR_037254
Natural varianti396 – 3961T → M.1 Publication
Corresponds to variant rs17851745 [ dbSNP | Ensembl ].
VAR_037255

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei594 – 61320LVQDL…TLETQ → SVIGVSSEETLITCLEIAMR in isoform 2. 1 PublicationVSP_029571Add
BLAST
Alternative sequencei614 – 1093480Missing in isoform 2. 1 PublicationVSP_029572Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471062 Genomic DNA. Translation: EAW62246.1.
BC009325 mRNA. Translation: AAH09325.2.
BC019341 mRNA. Translation: AAH19341.1.
AJ131244 mRNA. Translation: CAA10334.1. Frameshift.
CCDSiCCDS43363.1. [O95486-1]
CCDS58967.1. [O95486-2]
RefSeqiNP_001239160.1. NM_001252231.1. [O95486-2]
NP_068817.1. NM_021982.2. [O95486-1]
XP_005271911.1. XM_005271854.1.
UniGeneiHs.595540.

Genome annotation databases

EnsembliENST00000322887; ENSP00000321749; ENSG00000113615. [O95486-2]
ENST00000398844; ENSP00000381823; ENSG00000113615. [O95486-1]
GeneIDi10802.
KEGGihsa:10802.
UCSCiuc003kzs.3. human. [O95486-1]
uc021ydr.1. human. [O95486-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

COPII entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471062 Genomic DNA. Translation: EAW62246.1 .
BC009325 mRNA. Translation: AAH09325.2 .
BC019341 mRNA. Translation: AAH19341.1 .
AJ131244 mRNA. Translation: CAA10334.1 . Frameshift.
CCDSi CCDS43363.1. [O95486-1 ]
CCDS58967.1. [O95486-2 ]
RefSeqi NP_001239160.1. NM_001252231.1. [O95486-2 ]
NP_068817.1. NM_021982.2. [O95486-1 ]
XP_005271911.1. XM_005271854.1.
UniGenei Hs.595540.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2NUP X-ray 2.80 B 341-1093 [» ]
2NUT X-ray 2.30 B 341-1093 [» ]
3EGD X-ray 2.70 B 346-1093 [» ]
3EGX X-ray 3.30 B 346-1093 [» ]
ProteinModelPortali O95486.
SMRi O95486. Positions 346-1093.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116016. 48 interactions.
IntActi O95486. 5 interactions.
MINTi MINT-1479845.
STRINGi 9606.ENSP00000381823.

PTM databases

PhosphoSitei O95486.

Proteomic databases

MaxQBi O95486.
PaxDbi O95486.
PRIDEi O95486.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322887 ; ENSP00000321749 ; ENSG00000113615 . [O95486-2 ]
ENST00000398844 ; ENSP00000381823 ; ENSG00000113615 . [O95486-1 ]
GeneIDi 10802.
KEGGi hsa:10802.
UCSCi uc003kzs.3. human. [O95486-1 ]
uc021ydr.1. human. [O95486-2 ]

Organism-specific databases

CTDi 10802.
GeneCardsi GC05P134011.
H-InvDB HIX0005186.
HGNCi HGNC:10703. SEC24A.
HPAi HPA038901.
MIMi 607183. gene.
neXtProti NX_O95486.
PharmGKBi PA35626.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5028.
GeneTreei ENSGT00590000082962.
HOGENOMi HOG000196365.
HOVERGENi HBG054850.
InParanoidi O95486.
KOi K14007.
OMAi FAHEFGE.
OrthoDBi EOG7R56RS.
PhylomeDBi O95486.
TreeFami TF350406.

Enzyme and pathway databases

Reactomei REACT_121399. MHC class II antigen presentation.
REACT_12507. COPII (Coat Protein 2) Mediated Vesicle Transport.
REACT_147797. Regulation of cholesterol biosynthesis by SREBP (SREBF).
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSi SEC24A. human.
EvolutionaryTracei O95486.
GenomeRNAii 10802.
NextBioi 41025.
PROi O95486.
SOURCEi Search...

Gene expression databases

Bgeei O95486.
CleanExi HS_SEC24A.
Genevestigatori O95486.

Family and domain databases

Gene3Di 3.40.20.10. 1 hit.
3.40.50.410. 1 hit.
InterProi IPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
[Graphical view ]
Pfami PF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 690-1093 (ISOFORM 1), VARIANTS ILE-302 AND MET-396.
    Tissue: Brain and Eye.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-1093 (ISOFORM 1).
    Tissue: B-cell.
  4. "Selective export of human GPI-anchored proteins from the endoplasmic reticulum."
    Bonnon C., Wendeler M.W., Paccaud J.P., Hauri H.P.
    J. Cell Sci. 123:1705-1715(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TMED2.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSC24A_HUMAN
AccessioniPrimary (citable) accession number: O95486
Secondary accession number(s): A8MVW3, Q8WUV2, Q96GP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 13, 2007
Last modified: November 26, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3