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O95486

- SC24A_HUMAN

UniProt

O95486 - SC24A_HUMAN

Protein

Protein transport protein Sec24A

Gene

SEC24A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    2. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    3. cellular protein metabolic process Source: Reactome
    4. COPII vesicle coating Source: Reactome
    5. ER to Golgi vesicle-mediated transport Source: Reactome
    6. intracellular protein transport Source: InterPro
    7. membrane organization Source: Reactome
    8. post-translational protein modification Source: Reactome
    9. protein N-linked glycosylation via asparagine Source: Reactome
    10. small molecule metabolic process Source: Reactome

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_121399. MHC class II antigen presentation.
    REACT_12507. COPII (Coat Protein 2) Mediated Vesicle Transport.
    REACT_147797. Regulation of cholesterol biosynthesis by SREBP (SREBF).
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein transport protein Sec24A
    Alternative name(s):
    SEC24-related protein A
    Gene namesi
    Name:SEC24A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:10703. SEC24A.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Endoplasmic reticulum membrane By similarity. Golgi apparatus membrane By similarity

    GO - Cellular componenti

    1. COPII vesicle coat Source: InterPro
    2. cytosol Source: Reactome
    3. endoplasmic reticulum membrane Source: Reactome
    4. ER to Golgi transport vesicle membrane Source: Reactome
    5. Golgi membrane Source: UniProtKB-SubCell
    6. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35626.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10931093Protein transport protein Sec24APRO_0000205153Add
    BLAST

    Proteomic databases

    MaxQBiO95486.
    PaxDbiO95486.
    PRIDEiO95486.

    PTM databases

    PhosphoSiteiO95486.

    Expressioni

    Tissue specificityi

    Expressed in fibroblasts, hepatocytes, and lymphocytes.

    Gene expression databases

    BgeeiO95486.
    CleanExiHS_SEC24A.
    GenevestigatoriO95486.

    Organism-specific databases

    HPAiHPA038901.

    Interactioni

    Subunit structurei

    COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. SEC24A is capable of forming heterodimers with SEC24B and SEC24C. Interacts with TMED2.1 Publication

    Protein-protein interaction databases

    BioGridi116016. 46 interactions.
    IntActiO95486. 5 interactions.
    MINTiMINT-1479845.
    STRINGi9606.ENSP00000381823.

    Structurei

    Secondary structure

    1
    1093
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi350 – 3523
    Helixi353 – 3564
    Helixi374 – 3774
    Turni383 – 3853
    Beta strandi386 – 39611
    Helixi397 – 4037
    Beta strandi408 – 4114
    Turni432 – 4343
    Beta strandi442 – 45110
    Turni453 – 4553
    Beta strandi458 – 4603
    Helixi477 – 4793
    Helixi481 – 4844
    Beta strandi486 – 4916
    Helixi494 – 4963
    Beta strandi498 – 5003
    Beta strandi505 – 5117
    Helixi514 – 5196
    Helixi521 – 53212
    Turni533 – 5353
    Beta strandi543 – 55715
    Beta strandi562 – 5643
    Beta strandi566 – 5705
    Beta strandi581 – 5877
    Turni588 – 5914
    Helixi592 – 60110
    Helixi602 – 6043
    Turni605 – 6084
    Helixi616 – 62712
    Turni628 – 6303
    Beta strandi632 – 6387
    Beta strandi657 – 6593
    Helixi672 – 68211
    Beta strandi685 – 6917
    Helixi699 – 7024
    Helixi704 – 7074
    Turni708 – 7103
    Beta strandi713 – 7153
    Turni721 – 7233
    Helixi725 – 74016
    Beta strandi744 – 75310
    Beta strandi757 – 76812
    Beta strandi770 – 7723
    Beta strandi774 – 7796
    Beta strandi785 – 7939
    Beta strandi799 – 81012
    Beta strandi816 – 82813
    Helixi831 – 8366
    Helixi840 – 85718
    Helixi860 – 87920
    Beta strandi891 – 8933
    Helixi894 – 8963
    Helixi899 – 90810
    Turni910 – 9123
    Helixi920 – 93213
    Helixi935 – 9428
    Beta strandi945 – 9484
    Beta strandi954 – 9563
    Turni975 – 9773
    Beta strandi982 – 9876
    Beta strandi989 – 9968
    Helixi1002 – 10076
    Helixi1014 – 10163
    Helixi1030 – 104314
    Beta strandi1046 – 10483
    Beta strandi1051 – 10533
    Beta strandi1058 – 10614
    Helixi1066 – 10683
    Helixi1080 – 109112

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2NUPX-ray2.80B341-1093[»]
    2NUTX-ray2.30B341-1093[»]
    3EGDX-ray2.70B346-1093[»]
    3EGXX-ray3.30B346-1093[»]
    ProteinModelPortaliO95486.
    SMRiO95486. Positions 346-1093.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO95486.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni431 – 45525Zinc finger-likeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi89 – 237149Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SEC23/SEC24 family. SEC24 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG5028.
    HOGENOMiHOG000196365.
    HOVERGENiHBG054850.
    InParanoidiO95486.
    KOiK14007.
    OMAiFAHEFGE.
    OrthoDBiEOG7R56RS.
    PhylomeDBiO95486.
    TreeFamiTF350406.

    Family and domain databases

    Gene3Di3.40.20.10. 1 hit.
    3.40.50.410. 1 hit.
    InterProiIPR029006. ADF-H/Gelsolin-like_dom.
    IPR007123. Gelsolin-like_dom.
    IPR006900. Sec23/24_helical_dom.
    IPR006896. Sec23/24_trunk_dom.
    IPR012990. Sec23_24_beta_S.
    IPR002035. VWF_A.
    IPR006895. Znf_Sec23_Sec24.
    [Graphical view]
    PfamiPF00626. Gelsolin. 1 hit.
    PF08033. Sec23_BS. 1 hit.
    PF04815. Sec23_helical. 1 hit.
    PF04811. Sec23_trunk. 1 hit.
    PF04810. zf-Sec23_Sec24. 1 hit.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 1 hit.
    SSF81811. SSF81811. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95486-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSQPGIPASG GAPASLQAQN GAALASGSPY TNGPVQNALL SSQESVSQGY     50
    NFQLPGSYPH PIPAKTLNPV SGQSNYGGSQ GSGQTLNRPP VASNPVTPSL 100
    HSGPAPRMPL PASQNPATTP MPSSSFLPEA NLPPPLNWQY NYPSTASQTN 150
    HCPRASSQPT VSGNTSLTTN HQYVSSGYPS LQNSFIKSGP SVPPLVNPPL 200
    PTTFQPGAPH GPPPAGGPPP VRALTPLTSS YRDVPQPLFN SAVNQEGITS 250
    NTNNGSMVVH SSYDEIEGGG LLATPQLTNK NPKMSRSVGY SYPSLPPGYQ 300
    NTTPPGATGV PPSSLNYPSG PQAFTQTPLG ANHLTTSMSG LSLQPEGLRV 350
    VNLLQERNML PSTPLKPPVP NLHEDIQKLN CNPELFRCTL TSIPQTQALL 400
    NKAKLPLGLL LHPFKDLVQL PVVTSSTIVR CRSCRTYINP FVSFLDQRRW 450
    KCNLCYRVND VPEEFLYNPL TRVYGEPHRR PEVQNATIEF MAPSEYMLRP 500
    PQPPVYLFVF DVSHNAVETG YLNSVCQSLL DNLDLLPGNT RTKIGFITFD 550
    STIHFYGLQE SLSQPQMLIV SDIEDVFIPM PENLLVNLNE SKELVQDLLK 600
    TLPQMFTKTL ETQSALGPAL QAAFKLMSPT GGRMSVFQTQ LPTLGVGALK 650
    PREEPNHRSS AKDIHMTPST DFYKKLALDC SGQQVAVDLF LLSGQYSDLA 700
    SLGCISRYSA GSVYYYPSYH HQHNPVQVQK LQKELQRYLT RKIGFEAVMR 750
    IRCTKGLSIH TFHGNFFVRS TDLLSLPNVN PDAGYAVQMS VEESLTDTQL 800
    VSFQSALLYT SSKGERRIRV HTLCLPVVST LNDVFLGADV QAISGLLANM 850
    AVDRSMTASL SDARDALVNA VIDSLSAYRS SVLSNQQPGL MVPFSLRLFP 900
    LFVLALLKQK SFQTGTNARL DERIFAMCQV KNQPLVYLML TTHPSLYRVD 950
    NLSDEGALNI SDRTIPQPPI LQLSVEKLSR DGAFLMDAGS VLMLWVGKNC 1000
    TQNFLSQVLG VQNYASIPQP MTDLPELDTP ESARIIAFIS WLREQRPFFP 1050
    ILYVIRDESP MKANFLQNMI EDRTESALSY YEFLLHIQQQ VNK 1093
    Length:1,093
    Mass (Da):119,749
    Last modified:November 13, 2007 - v2
    Checksum:iE21F3A1333674A6A
    GO
    Isoform 2 (identifier: O95486-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         594-613: LVQDLLKTLPQMFTKTLETQ → SVIGVSSEETLITCLEIAMR
         614-1093: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:613
    Mass (Da):66,010
    Checksum:i9D80E2297AC131C0
    GO

    Sequence cautioni

    The sequence CAA10334.1 differs from that shown. Reason: Frameshift at position 68.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti261 – 2611S → G.
    Corresponds to variant rs7718102 [ dbSNP | Ensembl ].
    VAR_037253
    Natural varianti302 – 3021T → I.1 Publication
    Corresponds to variant rs17851746 [ dbSNP | Ensembl ].
    VAR_037254
    Natural varianti396 – 3961T → M.1 Publication
    Corresponds to variant rs17851745 [ dbSNP | Ensembl ].
    VAR_037255

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei594 – 61320LVQDL…TLETQ → SVIGVSSEETLITCLEIAMR in isoform 2. 1 PublicationVSP_029571Add
    BLAST
    Alternative sequencei614 – 1093480Missing in isoform 2. 1 PublicationVSP_029572Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471062 Genomic DNA. Translation: EAW62246.1.
    BC009325 mRNA. Translation: AAH09325.2.
    BC019341 mRNA. Translation: AAH19341.1.
    AJ131244 mRNA. Translation: CAA10334.1. Frameshift.
    CCDSiCCDS43363.1. [O95486-1]
    CCDS58967.1. [O95486-2]
    RefSeqiNP_001239160.1. NM_001252231.1. [O95486-2]
    NP_068817.1. NM_021982.2. [O95486-1]
    XP_005271911.1. XM_005271854.1.
    UniGeneiHs.595540.

    Genome annotation databases

    EnsembliENST00000322887; ENSP00000321749; ENSG00000113615. [O95486-2]
    ENST00000398844; ENSP00000381823; ENSG00000113615. [O95486-1]
    GeneIDi10802.
    KEGGihsa:10802.
    UCSCiuc003kzs.3. human. [O95486-1]
    uc021ydr.1. human. [O95486-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    COPII entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471062 Genomic DNA. Translation: EAW62246.1 .
    BC009325 mRNA. Translation: AAH09325.2 .
    BC019341 mRNA. Translation: AAH19341.1 .
    AJ131244 mRNA. Translation: CAA10334.1 . Frameshift.
    CCDSi CCDS43363.1. [O95486-1 ]
    CCDS58967.1. [O95486-2 ]
    RefSeqi NP_001239160.1. NM_001252231.1. [O95486-2 ]
    NP_068817.1. NM_021982.2. [O95486-1 ]
    XP_005271911.1. XM_005271854.1.
    UniGenei Hs.595540.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2NUP X-ray 2.80 B 341-1093 [» ]
    2NUT X-ray 2.30 B 341-1093 [» ]
    3EGD X-ray 2.70 B 346-1093 [» ]
    3EGX X-ray 3.30 B 346-1093 [» ]
    ProteinModelPortali O95486.
    SMRi O95486. Positions 346-1093.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116016. 46 interactions.
    IntActi O95486. 5 interactions.
    MINTi MINT-1479845.
    STRINGi 9606.ENSP00000381823.

    PTM databases

    PhosphoSitei O95486.

    Proteomic databases

    MaxQBi O95486.
    PaxDbi O95486.
    PRIDEi O95486.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322887 ; ENSP00000321749 ; ENSG00000113615 . [O95486-2 ]
    ENST00000398844 ; ENSP00000381823 ; ENSG00000113615 . [O95486-1 ]
    GeneIDi 10802.
    KEGGi hsa:10802.
    UCSCi uc003kzs.3. human. [O95486-1 ]
    uc021ydr.1. human. [O95486-2 ]

    Organism-specific databases

    CTDi 10802.
    GeneCardsi GC05P134011.
    H-InvDB HIX0005186.
    HGNCi HGNC:10703. SEC24A.
    HPAi HPA038901.
    MIMi 607183. gene.
    neXtProti NX_O95486.
    PharmGKBi PA35626.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5028.
    HOGENOMi HOG000196365.
    HOVERGENi HBG054850.
    InParanoidi O95486.
    KOi K14007.
    OMAi FAHEFGE.
    OrthoDBi EOG7R56RS.
    PhylomeDBi O95486.
    TreeFami TF350406.

    Enzyme and pathway databases

    Reactomei REACT_121399. MHC class II antigen presentation.
    REACT_12507. COPII (Coat Protein 2) Mediated Vesicle Transport.
    REACT_147797. Regulation of cholesterol biosynthesis by SREBP (SREBF).
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Miscellaneous databases

    ChiTaRSi SEC24A. human.
    EvolutionaryTracei O95486.
    GenomeRNAii 10802.
    NextBioi 41025.
    PROi O95486.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95486.
    CleanExi HS_SEC24A.
    Genevestigatori O95486.

    Family and domain databases

    Gene3Di 3.40.20.10. 1 hit.
    3.40.50.410. 1 hit.
    InterProi IPR029006. ADF-H/Gelsolin-like_dom.
    IPR007123. Gelsolin-like_dom.
    IPR006900. Sec23/24_helical_dom.
    IPR006896. Sec23/24_trunk_dom.
    IPR012990. Sec23_24_beta_S.
    IPR002035. VWF_A.
    IPR006895. Znf_Sec23_Sec24.
    [Graphical view ]
    Pfami PF00626. Gelsolin. 1 hit.
    PF08033. Sec23_BS. 1 hit.
    PF04815. Sec23_helical. 1 hit.
    PF04811. Sec23_trunk. 1 hit.
    PF04810. zf-Sec23_Sec24. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 1 hit.
    SSF81811. SSF81811. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 690-1093 (ISOFORM 1), VARIANTS ILE-302 AND MET-396.
      Tissue: Brain and Eye.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-1093 (ISOFORM 1).
      Tissue: B-cell.
    4. "Selective export of human GPI-anchored proteins from the endoplasmic reticulum."
      Bonnon C., Wendeler M.W., Paccaud J.P., Hauri H.P.
      J. Cell Sci. 123:1705-1715(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TMED2.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSC24A_HUMAN
    AccessioniPrimary (citable) accession number: O95486
    Secondary accession number(s): A8MVW3, Q8WUV2, Q96GP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3