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Protein

Protein transport protein Sec24A

Gene

SEC24A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:20427317, PubMed:17499046, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi431ZincCombined sources1
Metal bindingi434ZincCombined sources1
Metal bindingi452ZincCombined sources1
Metal bindingi455ZincCombined sources1

GO - Molecular functioni

  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-2132295 MHC class II antigen presentation
R-HSA-5694530 Cargo concentration in the ER
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec24ACurated
Alternative name(s):
SEC24-related protein A
Gene namesi
Name:SEC24AImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113615.12
HGNCiHGNC:10703 SEC24A
MIMi607183 gene
neXtProtiNX_O95486

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi541R → A: Decreased ability to interact with and package the SNARE SEC22B cargo into COPII vesicles. Has no effect on other cargos packaging. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000113615
PharmGKBiPA35626

Polymorphism and mutation databases

BioMutaiSEC24A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002051531 – 1093Protein transport protein Sec24AAdd BLAST1093

Proteomic databases

EPDiO95486
MaxQBiO95486
PaxDbiO95486
PeptideAtlasiO95486
PRIDEiO95486

PTM databases

iPTMnetiO95486
PhosphoSitePlusiO95486

Expressioni

Gene expression databases

BgeeiENSG00000113615
CleanExiHS_SEC24A
ExpressionAtlasiO95486 baseline and differential
GenevisibleiO95486 HS

Organism-specific databases

HPAiHPA038901
HPA056825

Interactioni

Subunit structurei

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (PubMed:17499046). Interacts with TMED2 (PubMed:20427317). Interacts (as part of the Sec23/24 complex) with SEC22B; recruits SEC22B into COPII-coated vesicles for its transport from the endoplasmic reticulum to the Golgi (PubMed:17499046).2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116016, 61 interactors
IntActiO95486, 21 interactors
STRINGi9606.ENSP00000381823

Structurei

Secondary structure

11093
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi350 – 352Combined sources3
Helixi353 – 356Combined sources4
Helixi374 – 377Combined sources4
Turni383 – 385Combined sources3
Beta strandi386 – 396Combined sources11
Helixi397 – 403Combined sources7
Beta strandi408 – 411Combined sources4
Turni432 – 434Combined sources3
Beta strandi442 – 451Combined sources10
Turni453 – 455Combined sources3
Beta strandi458 – 460Combined sources3
Helixi463 – 465Combined sources3
Helixi477 – 479Combined sources3
Helixi481 – 484Combined sources4
Beta strandi486 – 491Combined sources6
Helixi494 – 496Combined sources3
Beta strandi498 – 500Combined sources3
Beta strandi505 – 511Combined sources7
Helixi514 – 519Combined sources6
Helixi521 – 532Combined sources12
Turni533 – 535Combined sources3
Beta strandi543 – 557Combined sources15
Beta strandi562 – 564Combined sources3
Beta strandi566 – 570Combined sources5
Helixi573 – 575Combined sources3
Beta strandi581 – 587Combined sources7
Turni588 – 591Combined sources4
Helixi592 – 601Combined sources10
Helixi602 – 604Combined sources3
Turni605 – 608Combined sources4
Helixi616 – 627Combined sources12
Turni628 – 630Combined sources3
Beta strandi632 – 638Combined sources7
Beta strandi657 – 659Combined sources3
Helixi672 – 682Combined sources11
Beta strandi685 – 691Combined sources7
Helixi699 – 702Combined sources4
Helixi704 – 707Combined sources4
Turni708 – 710Combined sources3
Beta strandi713 – 715Combined sources3
Turni721 – 723Combined sources3
Helixi725 – 740Combined sources16
Beta strandi744 – 753Combined sources10
Beta strandi757 – 768Combined sources12
Beta strandi770 – 772Combined sources3
Beta strandi774 – 779Combined sources6
Beta strandi785 – 793Combined sources9
Beta strandi799 – 810Combined sources12
Beta strandi816 – 828Combined sources13
Helixi831 – 836Combined sources6
Helixi840 – 857Combined sources18
Helixi860 – 879Combined sources20
Beta strandi891 – 893Combined sources3
Helixi894 – 896Combined sources3
Helixi899 – 908Combined sources10
Turni910 – 912Combined sources3
Helixi920 – 932Combined sources13
Helixi935 – 942Combined sources8
Beta strandi945 – 948Combined sources4
Beta strandi954 – 956Combined sources3
Beta strandi960 – 962Combined sources3
Turni975 – 977Combined sources3
Beta strandi982 – 987Combined sources6
Beta strandi989 – 996Combined sources8
Helixi1002 – 1007Combined sources6
Helixi1014 – 1016Combined sources3
Helixi1030 – 1043Combined sources14
Beta strandi1046 – 1048Combined sources3
Beta strandi1051 – 1053Combined sources3
Beta strandi1058 – 1061Combined sources4
Helixi1066 – 1068Combined sources3
Beta strandi1075 – 1077Combined sources3
Helixi1080 – 1091Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NUPX-ray2.80B341-1093[»]
2NUTX-ray2.30B341-1093[»]
3EGDX-ray2.70B346-1093[»]
3EGXX-ray3.30B346-1093[»]
5VNEX-ray2.70B346-1093[»]
5VNFX-ray2.41B346-1093[»]
5VNGX-ray2.60B346-1093[»]
5VNHX-ray2.60B346-1093[»]
5VNIX-ray2.79B346-1093[»]
5VNJX-ray2.81B346-1093[»]
5VNKX-ray2.55B346-1093[»]
5VNLX-ray2.39B346-1093[»]
5VNMX-ray2.77B346-1093[»]
5VNNX-ray2.50B346-1093[»]
5VNOX-ray2.90B346-1093[»]
ProteinModelPortaliO95486
SMRiO95486
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95486

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati966 – 1038Gelsolin-likeSequence analysisAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni431 – 455Zinc finger-likeAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi89 – 237Pro-richAdd BLAST149

Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC24 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1985 Eukaryota
COG5028 LUCA
GeneTreeiENSGT00590000082962
HOGENOMiHOG000196365
HOVERGENiHBG054850
InParanoidiO95486
KOiK14007
OMAiQNFLSQV
OrthoDBiEOG091G011M
PhylomeDBiO95486
TreeFamiTF350406

Family and domain databases

Gene3Di3.40.20.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR036180 Gelsolin-like_dom_sf
IPR006900 Sec23/24_helical_dom
IPR036175 Sec23/24_helical_dom_sf
IPR006896 Sec23/24_trunk_dom
IPR012990 Sec23_24_beta_S
IPR036465 vWFA_dom_sf
IPR006895 Znf_Sec23_Sec24
PfamiView protein in Pfam
PF00626 Gelsolin, 1 hit
PF08033 Sec23_BS, 1 hit
PF04815 Sec23_helical, 1 hit
PF04811 Sec23_trunk, 1 hit
PF04810 zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF81811 SSF81811, 1 hit
SSF82754 SSF82754, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95486-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQPGIPASG GAPASLQAQN GAALASGSPY TNGPVQNALL SSQESVSQGY
60 70 80 90 100
NFQLPGSYPH PIPAKTLNPV SGQSNYGGSQ GSGQTLNRPP VASNPVTPSL
110 120 130 140 150
HSGPAPRMPL PASQNPATTP MPSSSFLPEA NLPPPLNWQY NYPSTASQTN
160 170 180 190 200
HCPRASSQPT VSGNTSLTTN HQYVSSGYPS LQNSFIKSGP SVPPLVNPPL
210 220 230 240 250
PTTFQPGAPH GPPPAGGPPP VRALTPLTSS YRDVPQPLFN SAVNQEGITS
260 270 280 290 300
NTNNGSMVVH SSYDEIEGGG LLATPQLTNK NPKMSRSVGY SYPSLPPGYQ
310 320 330 340 350
NTTPPGATGV PPSSLNYPSG PQAFTQTPLG ANHLTTSMSG LSLQPEGLRV
360 370 380 390 400
VNLLQERNML PSTPLKPPVP NLHEDIQKLN CNPELFRCTL TSIPQTQALL
410 420 430 440 450
NKAKLPLGLL LHPFKDLVQL PVVTSSTIVR CRSCRTYINP FVSFLDQRRW
460 470 480 490 500
KCNLCYRVND VPEEFLYNPL TRVYGEPHRR PEVQNATIEF MAPSEYMLRP
510 520 530 540 550
PQPPVYLFVF DVSHNAVETG YLNSVCQSLL DNLDLLPGNT RTKIGFITFD
560 570 580 590 600
STIHFYGLQE SLSQPQMLIV SDIEDVFIPM PENLLVNLNE SKELVQDLLK
610 620 630 640 650
TLPQMFTKTL ETQSALGPAL QAAFKLMSPT GGRMSVFQTQ LPTLGVGALK
660 670 680 690 700
PREEPNHRSS AKDIHMTPST DFYKKLALDC SGQQVAVDLF LLSGQYSDLA
710 720 730 740 750
SLGCISRYSA GSVYYYPSYH HQHNPVQVQK LQKELQRYLT RKIGFEAVMR
760 770 780 790 800
IRCTKGLSIH TFHGNFFVRS TDLLSLPNVN PDAGYAVQMS VEESLTDTQL
810 820 830 840 850
VSFQSALLYT SSKGERRIRV HTLCLPVVST LNDVFLGADV QAISGLLANM
860 870 880 890 900
AVDRSMTASL SDARDALVNA VIDSLSAYRS SVLSNQQPGL MVPFSLRLFP
910 920 930 940 950
LFVLALLKQK SFQTGTNARL DERIFAMCQV KNQPLVYLML TTHPSLYRVD
960 970 980 990 1000
NLSDEGALNI SDRTIPQPPI LQLSVEKLSR DGAFLMDAGS VLMLWVGKNC
1010 1020 1030 1040 1050
TQNFLSQVLG VQNYASIPQP MTDLPELDTP ESARIIAFIS WLREQRPFFP
1060 1070 1080 1090
ILYVIRDESP MKANFLQNMI EDRTESALSY YEFLLHIQQQ VNK
Length:1,093
Mass (Da):119,749
Last modified:November 13, 2007 - v2
Checksum:iE21F3A1333674A6A
GO
Isoform 2 (identifier: O95486-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     594-613: LVQDLLKTLPQMFTKTLETQ → SVIGVSSEETLITCLEIAMR
     614-1093: Missing.

Note: No experimental confirmation available.
Show »
Length:613
Mass (Da):66,010
Checksum:i9D80E2297AC131C0
GO

Sequence cautioni

The sequence CAA10334 differs from that shown. Reason: Frameshift at position 68.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037253261S → G. Corresponds to variant dbSNP:rs7718102Ensembl.1
Natural variantiVAR_037254302T → I1 PublicationCorresponds to variant dbSNP:rs17851746Ensembl.1
Natural variantiVAR_037255396T → M1 PublicationCorresponds to variant dbSNP:rs17851745Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029571594 – 613LVQDL…TLETQ → SVIGVSSEETLITCLEIAMR in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_029572614 – 1093Missing in isoform 2. 1 PublicationAdd BLAST480

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471062 Genomic DNA Translation: EAW62246.1
BC009325 mRNA Translation: AAH09325.2
BC019341 mRNA Translation: AAH19341.1
AJ131244 mRNA Translation: CAA10334.1 Frameshift.
CCDSiCCDS43363.1 [O95486-1]
CCDS58967.1 [O95486-2]
RefSeqiNP_001239160.1, NM_001252231.1 [O95486-2]
NP_068817.1, NM_021982.2 [O95486-1]
UniGeneiHs.595540

Genome annotation databases

EnsembliENST00000322887; ENSP00000321749; ENSG00000113615 [O95486-2]
ENST00000398844; ENSP00000381823; ENSG00000113615 [O95486-1]
GeneIDi10802
KEGGihsa:10802
UCSCiuc003kzs.4 human [O95486-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSC24A_HUMAN
AccessioniPrimary (citable) accession number: O95486
Secondary accession number(s): A8MVW3, Q8WUV2, Q96GP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 13, 2007
Last modified: May 23, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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