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Protein

Protein transport protein Sec24A

Gene

SEC24A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113615-MONOMER.
ReactomeiR-HSA-1655829. Regulation of cholesterol biosynthesis by SREBP (SREBF).
R-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-5694530. Cargo concentration in the ER.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec24A
Alternative name(s):
SEC24-related protein A
Gene namesi
Name:SEC24A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:10703. SEC24A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10802.
OpenTargetsiENSG00000113615.
PharmGKBiPA35626.

Polymorphism and mutation databases

BioMutaiSEC24A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002051532 – 1093Protein transport protein Sec24AAdd BLAST1092

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO95486.
MaxQBiO95486.
PaxDbiO95486.
PeptideAtlasiO95486.
PRIDEiO95486.

PTM databases

iPTMnetiO95486.
PhosphoSitePlusiO95486.

Expressioni

Tissue specificityi

Expressed in fibroblasts, hepatocytes, and lymphocytes.

Gene expression databases

BgeeiENSG00000113615.
CleanExiHS_SEC24A.
ExpressionAtlasiO95486. baseline and differential.
GenevisibleiO95486. HS.

Organism-specific databases

HPAiHPA038901.
HPA056825.

Interactioni

Subunit structurei

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. SEC24A is capable of forming heterodimers with SEC24B and SEC24C. Interacts with TMED2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EWSR1Q018443EBI-749911,EBI-739737
TFGQ927343EBI-749911,EBI-357061

Protein-protein interaction databases

BioGridi116016. 56 interactors.
IntActiO95486. 13 interactors.
MINTiMINT-1479845.
STRINGi9606.ENSP00000381823.

Structurei

Secondary structure

11093
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi350 – 352Combined sources3
Helixi353 – 356Combined sources4
Helixi374 – 377Combined sources4
Turni383 – 385Combined sources3
Beta strandi386 – 396Combined sources11
Helixi397 – 403Combined sources7
Beta strandi408 – 411Combined sources4
Turni432 – 434Combined sources3
Beta strandi442 – 451Combined sources10
Turni453 – 455Combined sources3
Beta strandi458 – 460Combined sources3
Helixi477 – 479Combined sources3
Helixi481 – 484Combined sources4
Beta strandi486 – 491Combined sources6
Helixi494 – 496Combined sources3
Beta strandi498 – 500Combined sources3
Beta strandi505 – 511Combined sources7
Helixi514 – 519Combined sources6
Helixi521 – 532Combined sources12
Turni533 – 535Combined sources3
Beta strandi543 – 557Combined sources15
Beta strandi562 – 564Combined sources3
Beta strandi566 – 570Combined sources5
Beta strandi581 – 587Combined sources7
Turni588 – 591Combined sources4
Helixi592 – 601Combined sources10
Helixi602 – 604Combined sources3
Turni605 – 608Combined sources4
Helixi616 – 627Combined sources12
Turni628 – 630Combined sources3
Beta strandi632 – 638Combined sources7
Beta strandi657 – 659Combined sources3
Helixi672 – 682Combined sources11
Beta strandi685 – 691Combined sources7
Helixi699 – 702Combined sources4
Helixi704 – 707Combined sources4
Turni708 – 710Combined sources3
Beta strandi713 – 715Combined sources3
Turni721 – 723Combined sources3
Helixi725 – 740Combined sources16
Beta strandi744 – 753Combined sources10
Beta strandi757 – 768Combined sources12
Beta strandi770 – 772Combined sources3
Beta strandi774 – 779Combined sources6
Beta strandi785 – 793Combined sources9
Beta strandi799 – 810Combined sources12
Beta strandi816 – 828Combined sources13
Helixi831 – 836Combined sources6
Helixi840 – 857Combined sources18
Helixi860 – 879Combined sources20
Beta strandi891 – 893Combined sources3
Helixi894 – 896Combined sources3
Helixi899 – 908Combined sources10
Turni910 – 912Combined sources3
Helixi920 – 932Combined sources13
Helixi935 – 942Combined sources8
Beta strandi945 – 948Combined sources4
Beta strandi954 – 956Combined sources3
Turni975 – 977Combined sources3
Beta strandi982 – 987Combined sources6
Beta strandi989 – 996Combined sources8
Helixi1002 – 1007Combined sources6
Helixi1014 – 1016Combined sources3
Helixi1030 – 1043Combined sources14
Beta strandi1046 – 1048Combined sources3
Beta strandi1051 – 1053Combined sources3
Beta strandi1058 – 1061Combined sources4
Helixi1066 – 1068Combined sources3
Helixi1080 – 1091Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NUPX-ray2.80B341-1093[»]
2NUTX-ray2.30B341-1093[»]
3EGDX-ray2.70B346-1093[»]
3EGXX-ray3.30B346-1093[»]
ProteinModelPortaliO95486.
SMRiO95486.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95486.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni431 – 455Zinc finger-likeAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi89 – 237Pro-richAdd BLAST149

Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC24 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1985. Eukaryota.
COG5028. LUCA.
GeneTreeiENSGT00590000082962.
HOGENOMiHOG000196365.
HOVERGENiHBG054850.
InParanoidiO95486.
KOiK14007.
OMAiGSYPHPI.
OrthoDBiEOG091G011M.
PhylomeDBiO95486.
TreeFamiTF350406.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
[Graphical view]
PfamiPF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
SSF82754. SSF82754. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95486-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQPGIPASG GAPASLQAQN GAALASGSPY TNGPVQNALL SSQESVSQGY
60 70 80 90 100
NFQLPGSYPH PIPAKTLNPV SGQSNYGGSQ GSGQTLNRPP VASNPVTPSL
110 120 130 140 150
HSGPAPRMPL PASQNPATTP MPSSSFLPEA NLPPPLNWQY NYPSTASQTN
160 170 180 190 200
HCPRASSQPT VSGNTSLTTN HQYVSSGYPS LQNSFIKSGP SVPPLVNPPL
210 220 230 240 250
PTTFQPGAPH GPPPAGGPPP VRALTPLTSS YRDVPQPLFN SAVNQEGITS
260 270 280 290 300
NTNNGSMVVH SSYDEIEGGG LLATPQLTNK NPKMSRSVGY SYPSLPPGYQ
310 320 330 340 350
NTTPPGATGV PPSSLNYPSG PQAFTQTPLG ANHLTTSMSG LSLQPEGLRV
360 370 380 390 400
VNLLQERNML PSTPLKPPVP NLHEDIQKLN CNPELFRCTL TSIPQTQALL
410 420 430 440 450
NKAKLPLGLL LHPFKDLVQL PVVTSSTIVR CRSCRTYINP FVSFLDQRRW
460 470 480 490 500
KCNLCYRVND VPEEFLYNPL TRVYGEPHRR PEVQNATIEF MAPSEYMLRP
510 520 530 540 550
PQPPVYLFVF DVSHNAVETG YLNSVCQSLL DNLDLLPGNT RTKIGFITFD
560 570 580 590 600
STIHFYGLQE SLSQPQMLIV SDIEDVFIPM PENLLVNLNE SKELVQDLLK
610 620 630 640 650
TLPQMFTKTL ETQSALGPAL QAAFKLMSPT GGRMSVFQTQ LPTLGVGALK
660 670 680 690 700
PREEPNHRSS AKDIHMTPST DFYKKLALDC SGQQVAVDLF LLSGQYSDLA
710 720 730 740 750
SLGCISRYSA GSVYYYPSYH HQHNPVQVQK LQKELQRYLT RKIGFEAVMR
760 770 780 790 800
IRCTKGLSIH TFHGNFFVRS TDLLSLPNVN PDAGYAVQMS VEESLTDTQL
810 820 830 840 850
VSFQSALLYT SSKGERRIRV HTLCLPVVST LNDVFLGADV QAISGLLANM
860 870 880 890 900
AVDRSMTASL SDARDALVNA VIDSLSAYRS SVLSNQQPGL MVPFSLRLFP
910 920 930 940 950
LFVLALLKQK SFQTGTNARL DERIFAMCQV KNQPLVYLML TTHPSLYRVD
960 970 980 990 1000
NLSDEGALNI SDRTIPQPPI LQLSVEKLSR DGAFLMDAGS VLMLWVGKNC
1010 1020 1030 1040 1050
TQNFLSQVLG VQNYASIPQP MTDLPELDTP ESARIIAFIS WLREQRPFFP
1060 1070 1080 1090
ILYVIRDESP MKANFLQNMI EDRTESALSY YEFLLHIQQQ VNK
Length:1,093
Mass (Da):119,749
Last modified:November 13, 2007 - v2
Checksum:iE21F3A1333674A6A
GO
Isoform 2 (identifier: O95486-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     594-613: LVQDLLKTLPQMFTKTLETQ → SVIGVSSEETLITCLEIAMR
     614-1093: Missing.

Note: No experimental confirmation available.
Show »
Length:613
Mass (Da):66,010
Checksum:i9D80E2297AC131C0
GO

Sequence cautioni

The sequence CAA10334 differs from that shown. Reason: Frameshift at position 68.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037253261S → G.Corresponds to variant rs7718102dbSNPEnsembl.1
Natural variantiVAR_037254302T → I.1 PublicationCorresponds to variant rs17851746dbSNPEnsembl.1
Natural variantiVAR_037255396T → M.1 PublicationCorresponds to variant rs17851745dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029571594 – 613LVQDL…TLETQ → SVIGVSSEETLITCLEIAMR in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_029572614 – 1093Missing in isoform 2. 1 PublicationAdd BLAST480

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471062 Genomic DNA. Translation: EAW62246.1.
BC009325 mRNA. Translation: AAH09325.2.
BC019341 mRNA. Translation: AAH19341.1.
AJ131244 mRNA. Translation: CAA10334.1. Frameshift.
CCDSiCCDS43363.1. [O95486-1]
CCDS58967.1. [O95486-2]
RefSeqiNP_001239160.1. NM_001252231.1. [O95486-2]
NP_068817.1. NM_021982.2. [O95486-1]
UniGeneiHs.595540.

Genome annotation databases

EnsembliENST00000322887; ENSP00000321749; ENSG00000113615. [O95486-2]
ENST00000398844; ENSP00000381823; ENSG00000113615. [O95486-1]
GeneIDi10802.
KEGGihsa:10802.
UCSCiuc003kzs.4. human. [O95486-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

COPII entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471062 Genomic DNA. Translation: EAW62246.1.
BC009325 mRNA. Translation: AAH09325.2.
BC019341 mRNA. Translation: AAH19341.1.
AJ131244 mRNA. Translation: CAA10334.1. Frameshift.
CCDSiCCDS43363.1. [O95486-1]
CCDS58967.1. [O95486-2]
RefSeqiNP_001239160.1. NM_001252231.1. [O95486-2]
NP_068817.1. NM_021982.2. [O95486-1]
UniGeneiHs.595540.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NUPX-ray2.80B341-1093[»]
2NUTX-ray2.30B341-1093[»]
3EGDX-ray2.70B346-1093[»]
3EGXX-ray3.30B346-1093[»]
ProteinModelPortaliO95486.
SMRiO95486.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116016. 56 interactors.
IntActiO95486. 13 interactors.
MINTiMINT-1479845.
STRINGi9606.ENSP00000381823.

PTM databases

iPTMnetiO95486.
PhosphoSitePlusiO95486.

Polymorphism and mutation databases

BioMutaiSEC24A.

Proteomic databases

EPDiO95486.
MaxQBiO95486.
PaxDbiO95486.
PeptideAtlasiO95486.
PRIDEiO95486.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322887; ENSP00000321749; ENSG00000113615. [O95486-2]
ENST00000398844; ENSP00000381823; ENSG00000113615. [O95486-1]
GeneIDi10802.
KEGGihsa:10802.
UCSCiuc003kzs.4. human. [O95486-1]

Organism-specific databases

CTDi10802.
DisGeNETi10802.
GeneCardsiSEC24A.
H-InvDBHIX0005186.
HGNCiHGNC:10703. SEC24A.
HPAiHPA038901.
HPA056825.
MIMi607183. gene.
neXtProtiNX_O95486.
OpenTargetsiENSG00000113615.
PharmGKBiPA35626.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1985. Eukaryota.
COG5028. LUCA.
GeneTreeiENSGT00590000082962.
HOGENOMiHOG000196365.
HOVERGENiHBG054850.
InParanoidiO95486.
KOiK14007.
OMAiGSYPHPI.
OrthoDBiEOG091G011M.
PhylomeDBiO95486.
TreeFamiTF350406.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113615-MONOMER.
ReactomeiR-HSA-1655829. Regulation of cholesterol biosynthesis by SREBP (SREBF).
R-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-5694530. Cargo concentration in the ER.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiSEC24A. human.
EvolutionaryTraceiO95486.
GenomeRNAii10802.
PROiO95486.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113615.
CleanExiHS_SEC24A.
ExpressionAtlasiO95486. baseline and differential.
GenevisibleiO95486. HS.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR006900. Sec23/24_helical_dom.
IPR006896. Sec23/24_trunk_dom.
IPR012990. Sec23_24_beta_S.
IPR002035. VWF_A.
IPR006895. Znf_Sec23_Sec24.
[Graphical view]
PfamiPF00626. Gelsolin. 1 hit.
PF08033. Sec23_BS. 1 hit.
PF04815. Sec23_helical. 1 hit.
PF04811. Sec23_trunk. 1 hit.
PF04810. zf-Sec23_Sec24. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF81811. SSF81811. 1 hit.
SSF82754. SSF82754. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSC24A_HUMAN
AccessioniPrimary (citable) accession number: O95486
Secondary accession number(s): A8MVW3, Q8WUV2, Q96GP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 13, 2007
Last modified: November 30, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.