Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Claudin-9

Gene

CLDN9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity (By similarity). May act as a coreceptor for HCV entry into hepatic cells.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-420029. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-9
Gene namesi
Name:CLDN9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:2051. CLDN9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence analysis
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Topological domaini29 – 8153ExtracellularSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Topological domaini103 – 11614CytoplasmicSequence analysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence analysisAdd
BLAST
Topological domaini138 – 15922ExtracellularSequence analysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence analysisAdd
BLAST
Topological domaini181 – 21737CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi38 – 381N → S: Mildly decrease HCV infection susceptibility in cell culture. 1 Publication
Mutagenesisi43 – 431A → S: No effect on HCV infection susceptibility in cell culture. 1 Publication
Mutagenesisi45 – 451V → N: Abolishes HCV infection susceptibility in cell culture. 1 Publication
Mutagenesisi53 – 531S → N: No effect on HCV infection susceptibility in cell culture. 1 Publication

Organism-specific databases

PharmGKBiPA26577.

Polymorphism and mutation databases

BioMutaiCLDN9.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Claudin-9PRO_0000144755Add
BLAST

Proteomic databases

PaxDbiO95484.
PeptideAtlasiO95484.
PRIDEiO95484.

PTM databases

iPTMnetiO95484.
PhosphoSiteiO95484.

Expressioni

Tissue specificityi

Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.1 Publication

Gene expression databases

BgeeiO95484.
CleanExiHS_CLDN9.
GenevisibleiO95484. HS.

Organism-specific databases

HPAiHPA007322.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000398017.

Structurei

3D structure databases

ProteinModelPortaliO95484.
SMRiO95484. Positions 4-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiO95484.
KOiK06087.
OMAiHAVIQDF.
OrthoDBiEOG79KPGQ.
PhylomeDBiO95484.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003553. Claudin9.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF42. PTHR12002:SF42. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01382. CLAUDIN9.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95484-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTGLELLG MTLAVLGWLG TLVSCALPLW KVTAFIGNSI VVAQVVWEGL
60 70 80 90 100
WMSCVVQSTG QMQCKVYDSL LALPQDLQAA RALCVIALLL ALLGLLVAIT
110 120 130 140 150
GAQCTTCVED EGAKARIVLT AGVILLLAGI LVLIPVCWTA HAIIQDFYNP
160 170 180 190 200
LVAEALKREL GASLYLGWAA AALLMLGGGL LCCTCPPPQV ERPRGPRLGY
210
SIPSRSGASG LDKRDYV
Length:217
Mass (Da):22,848
Last modified:May 1, 1999 - v1
Checksum:i0E49C5B5CB3AAC9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ130941 Genomic DNA. Translation: CAA10254.1.
BC051870 mRNA. Translation: AAH51870.1.
BC065830 mRNA. Translation: AAH65830.1.
CCDSiCCDS10487.1.
RefSeqiNP_066192.1. NM_020982.3.
UniGeneiHs.296949.

Genome annotation databases

EnsembliENST00000445369; ENSP00000398017; ENSG00000213937.
GeneIDi9080.
KEGGihsa:9080.
UCSCiuc010uwo.1. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ130941 Genomic DNA. Translation: CAA10254.1.
BC051870 mRNA. Translation: AAH51870.1.
BC065830 mRNA. Translation: AAH65830.1.
CCDSiCCDS10487.1.
RefSeqiNP_066192.1. NM_020982.3.
UniGeneiHs.296949.

3D structure databases

ProteinModelPortaliO95484.
SMRiO95484. Positions 4-184.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000398017.

PTM databases

iPTMnetiO95484.
PhosphoSiteiO95484.

Polymorphism and mutation databases

BioMutaiCLDN9.

Proteomic databases

PaxDbiO95484.
PeptideAtlasiO95484.
PRIDEiO95484.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000445369; ENSP00000398017; ENSG00000213937.
GeneIDi9080.
KEGGihsa:9080.
UCSCiuc010uwo.1. human.

Organism-specific databases

CTDi9080.
GeneCardsiCLDN9.
HGNCiHGNC:2051. CLDN9.
HPAiHPA007322.
MIMi615799. gene.
neXtProtiNX_O95484.
PharmGKBiPA26577.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiO95484.
KOiK06087.
OMAiHAVIQDF.
OrthoDBiEOG79KPGQ.
PhylomeDBiO95484.
TreeFamiTF331936.

Enzyme and pathway databases

ReactomeiR-HSA-420029. Tight junction interactions.

Miscellaneous databases

GeneWikiiCLDN9.
GenomeRNAii9080.
PROiO95484.
SOURCEiSearch...

Gene expression databases

BgeeiO95484.
CleanExiHS_CLDN9.
GenevisibleiO95484. HS.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003553. Claudin9.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF42. PTHR12002:SF42. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01382. CLAUDIN9.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Keen T.J., Inglehearn C.F.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Pituitary.
  3. "Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus."
    Zheng A., Yuan F., Li Y., Zhu F., Hou P., Li J., Song X., Ding M., Deng H.
    J. Virol. 81:12465-12471(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION AS CORECEPTOR FOR HCV, MUTAGENESIS OF ASN-38; ALA-43; VAL-45 AND SER-53.

Entry informationi

Entry nameiCLD9_HUMAN
AccessioniPrimary (citable) accession number: O95484
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.