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Protein

Claudin-9

Gene

CLDN9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity (By similarity). May act as a coreceptor for HCV entry into hepatic cells.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178709-MONOMER.
ReactomeiR-HSA-420029. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-9
Gene namesi
Name:CLDN9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:2051. CLDN9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 116CytoplasmicSequence analysisAdd BLAST14
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 159ExtracellularSequence analysisAdd BLAST22
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 217CytoplasmicSequence analysisAdd BLAST37

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi38N → S: Mildly decrease HCV infection susceptibility in cell culture. 1 Publication1
Mutagenesisi43A → S: No effect on HCV infection susceptibility in cell culture. 1 Publication1
Mutagenesisi45V → N: Abolishes HCV infection susceptibility in cell culture. 1 Publication1
Mutagenesisi53S → N: No effect on HCV infection susceptibility in cell culture. 1 Publication1

Organism-specific databases

DisGeNETi9080.
OpenTargetsiENSG00000213937.
PharmGKBiPA26577.

Polymorphism and mutation databases

BioMutaiCLDN9.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447551 – 217Claudin-9Add BLAST217

Proteomic databases

MaxQBiO95484.
PaxDbiO95484.
PeptideAtlasiO95484.
PRIDEiO95484.

PTM databases

iPTMnetiO95484.
PhosphoSitePlusiO95484.

Expressioni

Tissue specificityi

Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.1 Publication

Gene expression databases

BgeeiENSG00000213937.
CleanExiHS_CLDN9.
GenevisibleiO95484. HS.

Organism-specific databases

HPAiHPA007322.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000398017.

Structurei

3D structure databases

ProteinModelPortaliO95484.
SMRiO95484.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiO95484.
KOiK06087.
OMAiCPPPQIE.
OrthoDBiEOG091G0MMR.
PhylomeDBiO95484.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003553. Claudin9.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF42. PTHR12002:SF42. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01382. CLAUDIN9.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95484-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTGLELLG MTLAVLGWLG TLVSCALPLW KVTAFIGNSI VVAQVVWEGL
60 70 80 90 100
WMSCVVQSTG QMQCKVYDSL LALPQDLQAA RALCVIALLL ALLGLLVAIT
110 120 130 140 150
GAQCTTCVED EGAKARIVLT AGVILLLAGI LVLIPVCWTA HAIIQDFYNP
160 170 180 190 200
LVAEALKREL GASLYLGWAA AALLMLGGGL LCCTCPPPQV ERPRGPRLGY
210
SIPSRSGASG LDKRDYV
Length:217
Mass (Da):22,848
Last modified:May 1, 1999 - v1
Checksum:i0E49C5B5CB3AAC9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ130941 Genomic DNA. Translation: CAA10254.1.
BC051870 mRNA. Translation: AAH51870.1.
BC065830 mRNA. Translation: AAH65830.1.
CCDSiCCDS10487.1.
RefSeqiNP_066192.1. NM_020982.3.
UniGeneiHs.296949.

Genome annotation databases

EnsembliENST00000445369; ENSP00000398017; ENSG00000213937.
GeneIDi9080.
KEGGihsa:9080.
UCSCiuc010uwo.1. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ130941 Genomic DNA. Translation: CAA10254.1.
BC051870 mRNA. Translation: AAH51870.1.
BC065830 mRNA. Translation: AAH65830.1.
CCDSiCCDS10487.1.
RefSeqiNP_066192.1. NM_020982.3.
UniGeneiHs.296949.

3D structure databases

ProteinModelPortaliO95484.
SMRiO95484.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000398017.

PTM databases

iPTMnetiO95484.
PhosphoSitePlusiO95484.

Polymorphism and mutation databases

BioMutaiCLDN9.

Proteomic databases

MaxQBiO95484.
PaxDbiO95484.
PeptideAtlasiO95484.
PRIDEiO95484.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000445369; ENSP00000398017; ENSG00000213937.
GeneIDi9080.
KEGGihsa:9080.
UCSCiuc010uwo.1. human.

Organism-specific databases

CTDi9080.
DisGeNETi9080.
GeneCardsiCLDN9.
HGNCiHGNC:2051. CLDN9.
HPAiHPA007322.
MIMi615799. gene.
neXtProtiNX_O95484.
OpenTargetsiENSG00000213937.
PharmGKBiPA26577.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiO95484.
KOiK06087.
OMAiCPPPQIE.
OrthoDBiEOG091G0MMR.
PhylomeDBiO95484.
TreeFamiTF331936.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178709-MONOMER.
ReactomeiR-HSA-420029. Tight junction interactions.

Miscellaneous databases

GeneWikiiCLDN9.
GenomeRNAii9080.
PROiO95484.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213937.
CleanExiHS_CLDN9.
GenevisibleiO95484. HS.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003553. Claudin9.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF42. PTHR12002:SF42. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01382. CLAUDIN9.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD9_HUMAN
AccessioniPrimary (citable) accession number: O95484
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.