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Protein

Ribosome biogenesis protein NSA2 homolog

Gene

NSA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164346-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein NSA2 homolog
Alternative name(s):
Hairy cell leukemia protein 1
TGF-beta-inducible nuclear protein 1
Gene namesi
Name:NSA2
Synonyms:TINP1
ORF Names:HUSSY-29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30728. NSA2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10412.
OpenTargetsiENSG00000164346.
PharmGKBiPA165660390.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001222591 – 260Ribosome biogenesis protein NSA2 homologAdd BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95478.
PaxDbiO95478.
PeptideAtlasiO95478.
PRIDEiO95478.

2D gel databases

SWISS-2DPAGEO95478.

PTM databases

iPTMnetiO95478.
PhosphoSitePlusiO95478.

Expressioni

Gene expression databases

BgeeiENSG00000164346.
ExpressionAtlasiO95478. baseline and differential.
GenevisibleiO95478. HS.

Organism-specific databases

HPAiHPA043487.

Interactioni

Subunit structurei

Component of the pre-66S ribosomal particle.By similarity

Protein-protein interaction databases

BioGridi115683. 71 interactors.
IntActiO95478. 9 interactors.
MINTiMINT-3003003.
STRINGi9606.ENSP00000296802.

Structurei

3D structure databases

ProteinModelPortaliO95478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 152Lys-richAdd BLAST130

Sequence similaritiesi

Belongs to the ribosomal protein S8e family.Curated

Phylogenomic databases

eggNOGiKOG3163. Eukaryota.
COG2007. LUCA.
GeneTreeiENSGT00390000018706.
HOGENOMiHOG000234606.
HOVERGENiHBG047617.
InParanoidiO95478.
KOiK14842.
OMAiKEAREPH.
OrthoDBiEOG091G0IDG.
PhylomeDBiO95478.
TreeFamiTF300766.

Family and domain databases

InterProiIPR022309. Ribosomal_S8e/biogenesis_NSA2.
[Graphical view]
PfamiPF01201. Ribosomal_S8e. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95478-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQNEYIELH RKRYGYRLDY HEKKRKKESR EAHERSKKAK KMIGLKAKLY
60 70 80 90 100
HKQRHAEKIQ MKKTIKMHEK RNTKQKNDEK TPQGAVPAYL LDREGQSRAK
110 120 130 140 150
VLSNMIKQKR KEKAGKWEVP LPKVRAQGET EVLKVIRTGK RKKKAWKRMV
160 170 180 190 200
TKVCFVGDGF TRKPPKYERF IRPMGLRFKK AHVTHPELKA TFCLPILGVK
210 220 230 240 250
KNPSSPLYTT LGVITKGTVI EVNVSELGLV TQGGKVIWGK YAQVTNNPEN
260
DGCINAVLLV
Length:260
Mass (Da):30,065
Last modified:May 1, 1999 - v1
Checksum:iC42D3E8EFB2669D8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05186211R → C.Corresponds to variant rs3733793dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF372458 mRNA. Translation: AAK53761.1.
AJ012409 mRNA. Translation: CAA10008.1.
AF077615 mRNA. Translation: AAG43048.1.
BC005288 mRNA. Translation: AAH05288.1.
CCDSiCCDS4025.1.
RefSeqiNP_001258594.1. NM_001271665.1.
NP_055701.1. NM_014886.4.
UniGeneiHs.482526.

Genome annotation databases

EnsembliENST00000610426; ENSP00000483484; ENSG00000164346.
GeneIDi10412.
KEGGihsa:10412.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF372458 mRNA. Translation: AAK53761.1.
AJ012409 mRNA. Translation: CAA10008.1.
AF077615 mRNA. Translation: AAG43048.1.
BC005288 mRNA. Translation: AAH05288.1.
CCDSiCCDS4025.1.
RefSeqiNP_001258594.1. NM_001271665.1.
NP_055701.1. NM_014886.4.
UniGeneiHs.482526.

3D structure databases

ProteinModelPortaliO95478.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115683. 71 interactors.
IntActiO95478. 9 interactors.
MINTiMINT-3003003.
STRINGi9606.ENSP00000296802.

PTM databases

iPTMnetiO95478.
PhosphoSitePlusiO95478.

2D gel databases

SWISS-2DPAGEO95478.

Proteomic databases

EPDiO95478.
PaxDbiO95478.
PeptideAtlasiO95478.
PRIDEiO95478.

Protocols and materials databases

DNASUi10412.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000610426; ENSP00000483484; ENSG00000164346.
GeneIDi10412.
KEGGihsa:10412.

Organism-specific databases

CTDi10412.
DisGeNETi10412.
GeneCardsiNSA2.
HGNCiHGNC:30728. NSA2.
HPAiHPA043487.
MIMi612497. gene.
neXtProtiNX_O95478.
OpenTargetsiENSG00000164346.
PharmGKBiPA165660390.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3163. Eukaryota.
COG2007. LUCA.
GeneTreeiENSGT00390000018706.
HOGENOMiHOG000234606.
HOVERGENiHBG047617.
InParanoidiO95478.
KOiK14842.
OMAiKEAREPH.
OrthoDBiEOG091G0IDG.
PhylomeDBiO95478.
TreeFamiTF300766.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164346-MONOMER.

Miscellaneous databases

ChiTaRSiNSA2. human.
GeneWikiiTINP1.
GenomeRNAii10412.
PROiO95478.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164346.
ExpressionAtlasiO95478. baseline and differential.
GenevisibleiO95478. HS.

Family and domain databases

InterProiIPR022309. Ribosomal_S8e/biogenesis_NSA2.
[Graphical view]
PfamiPF01201. Ribosomal_S8e. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNSA2_HUMAN
AccessioniPrimary (citable) accession number: O95478
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.