O95478 (NSA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosome biogenesis protein NSA2 homolog

Alternative name(s):
Hairy cell leukemia protein 1
TGF-beta-inducible nuclear protein 1

Gene names

Name:	NSA2
Synonyms:	TINP1
ORF Names:	HUSSY-29

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles By similarity.
Subunit structure	Component of the pre-66S ribosomal particle By similarity.
Subcellular location	Nucleus › nucleolus Ref.5.
Sequence similarities	Belongs to the ribosomal protein S8e family.

Ontologies

Keywords
Biological process	Ribosome biogenesis rRNA processing
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Molecular function	Ribonucleoprotein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	rRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell ribonucleoprotein complex Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	Ribosome biogenesis protein NSA2 homolog		PRO_0000122259
Regions
	Compositional bias	23 – 152	130	Lys-rich
Amino acid modifications
	Modified residue	81	1	Phosphothreonine Ref.6 Ref.7
Natural variations
	Natural variant	11	1	R → C. Corresponds to variant rs3733793 [ dbSNP | Ensembl ].		VAR_051862

Sequences

	Sequence		Length	Mass (Da)
	O95478 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: C42D3E8EFB2669D8	FASTA	260	30,065
	10 20 30 40 50 60 MPQNEYIELH RKRYGYRLDY HEKKRKKESR EAHERSKKAK KMIGLKAKLY HKQRHAEKIQ 70 80 90 100 110 120 MKKTIKMHEK RNTKQKNDEK TPQGAVPAYL LDREGQSRAK VLSNMIKQKR KEKAGKWEVP 130 140 150 160 170 180 LPKVRAQGET EVLKVIRTGK RKKKAWKRMV TKVCFVGDGF TRKPPKYERF IRPMGLRFKK 190 200 210 220 230 240 AHVTHPELKA TFCLPILGVK KNPSSPLYTT LGVITKGTVI EVNVSELGLV TQGGKVIWGK 250 260 YAQVTNNPEN DGCINAVLLV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular analysis of the human chromosome 5q13.3 region in patients with hairy cell leukemia and identification of tumor suppressor gene candidates." Wu X., Ivanova G., Merup M., Jansson M., Stellan B., Grander D., Zabarovsky E., Gahrton G., Einhorn S. Genomics 60:161-171(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Characterization of 16 novel human genes showing high similarity to yeast sequences." Stanchi F., Bertocco E., Toppo S., Dioguardi R., Simionati B., Cannata N., Zimbello R., Lanfranchi G., Valle G. Yeast 18:69-80(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle.
[3]	"TGF beta induced nuclear protein." Zhang J.S., Smith D.I. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Urinary bladder.
[5]	"Functional proteomic analysis of human nucleolus." Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J. Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-81, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-81, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF372458 mRNA. Translation: AAK53761.1. AJ012409 mRNA. Translation: CAA10008.1. AF077615 mRNA. Translation: AAG43048.1. BC005288 mRNA. Translation: AAH05288.1.
IPI	IPI00007089.
RefSeq	NP_001258594.1. NM_001271665.1. NP_055701.1. NM_014886.4.
UniGene	Hs.482526.
3D structure databases
ProteinModelPortal	O95478.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95478. 2 interactions.
STRING	9606.ENSP00000296802.
PTM databases
PhosphoSite	O95478.
2D gel databases
SWISS-2DPAGE	O95478.
Proteomic databases
PaxDb	O95478.
PRIDE	O95478.
Protocols and materials databases
DNASU	10412.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000296802; ENSP00000296802; ENSG00000164346.
GeneID	10412.
KEGG	hsa:10412.
UCSC	uc003kdk.1. human.
Organism-specific databases
CTD	10412.
GeneCards	GC05P074062.
HGNC	HGNC:30728. NSA2.
HPA	HPA043487.
MIM	612497. gene.
neXtProt	NX_O95478.
PharmGKB	PA165660390.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2007.
HOGENOM	HOG000234606.
HOVERGEN	HBG047617.
InParanoid	O95478.
KO	K14842.
OMA	MPQNEHI.
OrthoDB	EOG405S1R.
PhylomeDB	O95478.
Gene expression databases
ArrayExpress	O95478.
Bgee	O95478.
Genevestigator	O95478.
GermOnline	ENSG00000164346. Homo sapiens.
Family and domain databases
InterPro	IPR022309. Ribosomal_S8e/biogenesis_NSA2. [Graphical view]
Pfam	PF01201. Ribosomal_S8e. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10412.
NextBio	39469.
SOURCE	Search...

Entry information

Entry name

NSA2_HUMAN

Accession

Primary (citable) accession number: O95478

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.