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Reviewed, UniProtKB/Swiss-Prot O95476 (DULRD_HUMAN)

Last modified February 9, 2010. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Serine/threonine-protein phosphatase dullard
    EC=3.1.3.16
Gene names
Name: DULLARD
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Serine/threonine phosphatase which may be required for proper nuclear membrane morphology. Involved in LPIN1 dephosphorylation. May antagonize BMP signaling. Ref.6

Catalytic activity

A phosphoprotein + H2O = a protein + phosphate.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein Ref.6 Ref.2.

Sequence similarities

Belongs to the dullard family.

Contains 1 FCP1 homology domain.

Biophysicochemical properties

Kinetic parameters:

KM=18 mM for p-nitrophenylphosphate

pH dependence:

Optimum pH is 5.5.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Nucleus
   Coding sequence diversityPolymorphism
   DomainTransmembrane
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processnuclear envelope organization Ref.6

Inferred from direct assay. Source: UniProtKB

protein amino acid dephosphorylation Ref.6

Inferred from direct assay. Source: UniProtKB

   Cellular componentendoplasmic reticulum membrane Ref.6

Inferred from direct assay. Source: UniProtKB

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

nuclear envelope Ref.6

Inferred from direct assay. Source: UniProtKB

   Molecular functionprotein serine/threonine phosphatase activity Ref.6

Inferred from mutant phenotype. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 244244Serine/threonine-protein phosphatase dullard
PRO_0000297967

Regions

Transmembrane7 – 2923 Potential
Domain57 – 224168FCP1 homology

Natural variations

Natural variant121T → A: dbSNP rs3744399. Ref.2 Ref.1
VAR_034699

Experimental info

Mutagenesis671D → N or E: Abolishes phosphatase activity. Ref.6

Sequences

Sequence LengthMass (Da)Tools
O95476-1 [UniParc].

Last modified November 3, 2009. Version 2.
Checksum: 062952A90F74575A

FASTA24428,377
        10         20         30         40         50         60 
MMRTQCLLGL RTFVAFAAKL WSFFIYLLRR QIRTVIQYQT VRYDILPLSP VSRNRLAQVK 

        70         80         90        100        110        120 
RKILVLDLDE TLIHSHHDGV LRPTVRPGTP PDFILKVVID KHPVRFFVHK RPHVDFFLEV 

       130        140        150        160        170        180 
VSQWYELVVF TASMEIYGSA VADKLDNSRS ILKRRYYRQH CTLELGSYIK DLSVVHSDLS 

       190        200        210        220        230        240 
SIVILDNSPG AYRSHPDNAI PIKSWFSDPS DTALLNLLPM LDALRFTADV RSVLSRNLHQ 


HRLW 

« Hide

References

« Hide 'large scale' references
[1]Keen J., Inglehearn C.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-12.
Tissue: Brain.
[2]"NovelFam3000 -- uncharacterized human protein domains conserved across model organisms."
Kemmer D., Podowski R.M., Arenillas D., Lim J., Hodges E., Roth P., Sonnhammer E.L.L., Hoeoeg C., Wasserman W.W.
BMC Genomics 7:48-48(2006) [PubMed: 16533400] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, VARIANT ALA-12.
[3]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed: 16625196] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[5]"Molecular cloning and characterization of dullard: a novel gene required for neural development."
Satow R., Chan T.C., Asashima M.
Biochem. Biophys. Res. Commun. 295:85-91(2002) [PubMed: 12083771] [Abstract]
Cited for: IDENTIFICATION.
[6]"A conserved phosphatase cascade that regulates nuclear membrane biogenesis."
Kim Y., Gentry M.S., Harris T.E., Wiley S.E., Lawrence J.C. Jr., Dixon J.E.
Proc. Natl. Acad. Sci. U.S.A. 104:6596-6601(2007) [PubMed: 17420445] [Abstract]
Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, MUTAGENESIS OF ASP-67, SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ011916 mRNA. Translation: CAA09865.1.
AY364239 mRNA. Translation: AAQ76798.1.
AC003688 Genomic DNA. No translation available.
AC120057 Genomic DNA. No translation available.
BC009295 mRNA. Translation: AAH09295.1.
IPIIPI00383704.
RefSeqNP_001137247.1.
NP_056158.2.
UniGeneHs.513913

3D structure databases

HSSPHSSP built from PDB template 1TA0 based on UniProtKB Q9GZU7.
ModBaseSearch...

Protein-protein interaction databases

STRINGO95476.

PTM databases

PhosphoSiteO95476.

Proteomic databases

PRIDEO95476.

Genome annotation databases

EnsemblENST00000318988; ENSP00000321732; ENSG00000175826; Homo sapiens. [Genome view]
ENST00000380825; ENSP00000370204; ENSG00000175826; Homo sapiens. [Genome view]
GeneID23399.
KEGGhsa:23399.
UCSCuc002gfd.1. human.

Organism-specific databases

CTD23399.
GeneCardsGC17M007087.
HGNCHGNC:19085. DULLARD.
MIM610684. gene.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG18902.
HOGENOMHBG603876.
HOVERGENO95476.
InParanoidO95476.
OrthoDBEOG9SR0GW.

Enzyme and pathway databases

BRENDA3.1.3.16. 247.

Gene expression databases

ArrayExpressO95476.
BgeeO95476.
CleanExHS_DULLARD.
GenevestigatorO95476.

Family and domain databases

InterProIPR011948. Dullard.
IPR004274. NIF.
[Graphical view]
PfamPF03031. NIF. 1 hit.
[Graphical view]
SMARTSM00577. CPDc. 1 hit.
[Graphical view]
TIGRFAMsTIGR02251. HIF-SF_euk. 1 hit.
PROSITEPS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio45549.
SOURCESearch...

Entry information

Entry nameDULRD_HUMAN
AccessionPrimary (citable) accession number: O95476
Secondary accession number(s): Q96GQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: November 3, 2009
Last modified: February 9, 2010
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents