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Protein

CTD nuclear envelope phosphatase 1

Gene

CTDNEP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling.2 Publications

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Kineticsi

  1. KM=18 mM for p-nitrophenylphosphate1 Publication

    pH dependencei

    Optimum pH is 5.5.1 Publication

    GO - Molecular functioni

    • protein serine/threonine phosphatase activity Source: UniProtKB

    GO - Biological processi

    • gamete generation Source: Ensembl
    • mesoderm development Source: Ensembl
    • mitotic nuclear envelope disassembly Source: Reactome
    • nuclear envelope organization Source: UniProtKB
    • positive regulation of canonical Wnt signaling pathway Source: Ensembl
    • positive regulation of triglyceride biosynthetic process Source: UniProtKB
    • protein dephosphorylation Source: UniProtKB
    • protein localization to nucleus Source: UniProtKB

    Keywordsi

    Molecular functionHydrolase, Protein phosphatase

    Enzyme and pathway databases

    ReactomeiR-HSA-4419969 Depolymerisation of the Nuclear Lamina
    SABIO-RKiO95476
    SignaLinkiO95476
    SIGNORiO95476

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CTD nuclear envelope phosphatase 1 (EC:3.1.3.16)
    Alternative name(s):
    Serine/threonine-protein phosphatase dullard
    Gene namesi
    Name:CTDNEP1
    Synonyms:DULLARD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 17

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000175826.11
    HGNCiHGNC:19085 CTDNEP1
    MIMi610684 gene
    neXtProtiNX_O95476

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Transmembranei7 – 29HelicalSequence analysisAdd BLAST23

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi67D → N or E: Abolishes phosphatase activity. 1 Publication1

    Organism-specific databases

    OpenTargetsiENSG00000175826
    PharmGKBiPA134937999

    Polymorphism and mutation databases

    BioMutaiCTDNEP1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002979671 – 244CTD nuclear envelope phosphatase 1Add BLAST244

    Proteomic databases

    EPDiO95476
    MaxQBiO95476
    PaxDbiO95476
    PeptideAtlasiO95476
    PRIDEiO95476
    ProteomicsDBi50907
    TopDownProteomicsiO95476

    PTM databases

    DEPODiO95476
    iPTMnetiO95476
    PhosphoSitePlusiO95476

    Expressioni

    Tissue specificityi

    Muscle specific with lower expression in other metabolic tissues.1 Publication

    Gene expression databases

    BgeeiENSG00000175826
    CleanExiHS_DULLARD
    ExpressionAtlasiO95476 baseline and differential
    GenevisibleiO95476 HS

    Organism-specific databases

    HPAiHPA037439
    HPA066466

    Interactioni

    Subunit structurei

    Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2.1 Publication

    Binary interactionsi

    Show more details

    Protein-protein interaction databases

    BioGridi116972, 53 interactors
    IntActiO95476, 5 interactors
    MINTiO95476
    STRINGi9606.ENSP00000321732

    Structurei

    3D structure databases

    ProteinModelPortaliO95476
    SMRiO95476
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini57 – 224FCP1 homologyPROSITE-ProRule annotationAdd BLAST168

    Sequence similaritiesi

    Belongs to the dullard family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG1605 Eukaryota
    COG5190 LUCA
    GeneTreeiENSGT00390000017194
    HOGENOMiHOG000236379
    HOVERGENiHBG098153
    InParanoidiO95476
    KOiK17617
    OMAiSRIWGFI
    OrthoDBiEOG091G0GIO
    PhylomeDBiO95476
    TreeFamiTF313962

    Family and domain databases

    Gene3Di3.40.50.1000, 1 hit
    InterProiView protein in InterPro
    IPR011948 Dullard_phosphatase
    IPR004274 FCP1_dom
    IPR036412 HAD-like_sf
    IPR023214 HAD_sf
    PfamiView protein in Pfam
    PF03031 NIF, 1 hit
    SMARTiView protein in SMART
    SM00577 CPDc, 1 hit
    SUPFAMiSSF56784 SSF56784, 1 hit
    TIGRFAMsiTIGR02251 HIF-SF_euk, 1 hit
    PROSITEiView protein in PROSITE
    PS50969 FCP1, 1 hit

    Sequencei

    Sequence statusi: Complete.

    O95476-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MMRTQCLLGL RTFVAFAAKL WSFFIYLLRR QIRTVIQYQT VRYDILPLSP
    60 70 80 90 100
    VSRNRLAQVK RKILVLDLDE TLIHSHHDGV LRPTVRPGTP PDFILKVVID
    110 120 130 140 150
    KHPVRFFVHK RPHVDFFLEV VSQWYELVVF TASMEIYGSA VADKLDNSRS
    160 170 180 190 200
    ILKRRYYRQH CTLELGSYIK DLSVVHSDLS SIVILDNSPG AYRSHPDNAI
    210 220 230 240
    PIKSWFSDPS DTALLNLLPM LDALRFTADV RSVLSRNLHQ HRLW
    Length:244
    Mass (Da):28,377
    Last modified:November 3, 2009 - v2
    Checksum:i062952A90F74575A
    GO

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_03469912T → A2 PublicationsCorresponds to variant dbSNP:rs3744399Ensembl.1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ011916 mRNA Translation: CAA09865.1
    AY364239 mRNA Translation: AAQ76798.1
    AC003688 Genomic DNA No translation available.
    AC120057 Genomic DNA No translation available.
    CH471108 Genomic DNA Translation: EAW90233.1
    CH471108 Genomic DNA Translation: EAW90235.1
    CH471108 Genomic DNA Translation: EAW90236.1
    BC009295 mRNA Translation: AAH09295.1
    CCDSiCCDS11093.1
    RefSeqiNP_001137247.1, NM_001143775.1
    NP_056158.2, NM_015343.4
    UniGeneiHs.513913

    Genome annotation databases

    EnsembliENST00000318988; ENSP00000321732; ENSG00000175826
    ENST00000573600; ENSP00000461749; ENSG00000175826
    ENST00000574205; ENSP00000458758; ENSG00000175826
    ENST00000574322; ENSP00000460683; ENSG00000175826
    GeneIDi23399
    KEGGihsa:23399
    UCSCiuc002gfd.3 human

    Keywords - Coding sequence diversityi

    Polymorphism

    Similar proteinsi

    Entry informationi

    Entry nameiCNEP1_HUMAN
    AccessioniPrimary (citable) accession number: O95476
    Secondary accession number(s): D3DTN7, Q96GQ9
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: November 3, 2009
    Last modified: June 20, 2018
    This is version 121 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

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