Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Synaptogyrin-4

Gene

SYNGR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptogyrin-4
Gene namesi
Name:SYNGR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:11502. SYNGR4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalSequence AnalysisAdd
BLAST
Transmembranei66 – 8621HelicalSequence AnalysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence AnalysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36284.

Polymorphism and mutation databases

BioMutaiSYNGR4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Synaptogyrin-4PRO_0000183998Add
BLAST

Proteomic databases

PaxDbiO95473.
PRIDEiO95473.

Expressioni

Gene expression databases

BgeeiO95473.
CleanExiHS_SYNGR4.
ExpressionAtlasiO95473. baseline.
GenevisibleiO95473. HS.

Organism-specific databases

HPAiHPA030075.
HPA059286.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000344041.

Structurei

3D structure databases

ProteinModelPortaliO95473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 169152MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptogyrin family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG297575.
GeneTreeiENSGT00510000046450.
HOGENOMiHOG000220816.
HOVERGENiHBG098537.
InParanoidiO95473.
OMAiWIFQAYL.
OrthoDBiEOG7VTDQ1.
PhylomeDBiO95473.
TreeFamiTF320995.

Family and domain databases

InterProiIPR008253. Marvel.
IPR016579. Synaptogyrin.
[Graphical view]
PANTHERiPTHR10838. PTHR10838. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PIRSFiPIRSF011282. Synaptogyrin. 1 hit.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHIPKSLQEL ANSEAVQFLR RPKTITRVFE GVFSLIVFSS LLTDGYQNKM
60 70 80 90 100
ESPQLHCILN SNSVACSFAV GAGFLAFLSC LAFLVLDTQE TRIAGTRFKT
110 120 130 140 150
AFQLLDFILA VLWAVVWFMG FCFLANQWQH SPPKEFLLGS SSAQAAIAFT
160 170 180 190 200
FFSILVWIFQ AYLAFQDLRN DAPVPYKRFL DEGGMVLTTL PLPSANSPVN
210 220 230
MPTTGPNSLS YASSALSPCL TAPKSPRLAM MPDN
Length:234
Mass (Da):25,820
Last modified:November 13, 2007 - v2
Checksum:i1CE517E82E2ABDE0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381F → I in CAA09754 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271R → W.
Corresponds to variant rs919804 [ dbSNP | Ensembl ].
VAR_052245

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011733 mRNA. Translation: CAA09754.1.
CH471177 Genomic DNA. Translation: EAW52339.1.
BC106891 mRNA. Translation: AAI06892.1.
CCDSiCCDS12717.1.
RefSeqiNP_036583.2. NM_012451.3.
XP_005258750.1. XM_005258693.2.
XP_005258751.1. XM_005258694.2.
UniGeneiHs.408333.

Genome annotation databases

EnsembliENST00000344846; ENSP00000344041; ENSG00000105467.
GeneIDi23546.
KEGGihsa:23546.
UCSCiuc002piz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011733 mRNA. Translation: CAA09754.1.
CH471177 Genomic DNA. Translation: EAW52339.1.
BC106891 mRNA. Translation: AAI06892.1.
CCDSiCCDS12717.1.
RefSeqiNP_036583.2. NM_012451.3.
XP_005258750.1. XM_005258693.2.
XP_005258751.1. XM_005258694.2.
UniGeneiHs.408333.

3D structure databases

ProteinModelPortaliO95473.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000344041.

Polymorphism and mutation databases

BioMutaiSYNGR4.

Proteomic databases

PaxDbiO95473.
PRIDEiO95473.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344846; ENSP00000344041; ENSG00000105467.
GeneIDi23546.
KEGGihsa:23546.
UCSCiuc002piz.3. human.

Organism-specific databases

CTDi23546.
GeneCardsiGC19P048867.
HGNCiHGNC:11502. SYNGR4.
HPAiHPA030075.
HPA059286.
MIMi608373. gene.
neXtProtiNX_O95473.
PharmGKBiPA36284.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG297575.
GeneTreeiENSGT00510000046450.
HOGENOMiHOG000220816.
HOVERGENiHBG098537.
InParanoidiO95473.
OMAiWIFQAYL.
OrthoDBiEOG7VTDQ1.
PhylomeDBiO95473.
TreeFamiTF320995.

Miscellaneous databases

GenomeRNAii23546.
NextBioi46080.
PROiO95473.
SOURCEiSearch...

Gene expression databases

BgeeiO95473.
CleanExiHS_SYNGR4.
ExpressionAtlasiO95473. baseline.
GenevisibleiO95473. HS.

Family and domain databases

InterProiIPR008253. Marvel.
IPR016579. Synaptogyrin.
[Graphical view]
PANTHERiPTHR10838. PTHR10838. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PIRSFiPIRSF011282. Synaptogyrin. 1 hit.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel member of synaptogyrin gene family."
    Kedra D., Dumanski J.P.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSNG4_HUMAN
AccessioniPrimary (citable) accession number: O95473
Secondary accession number(s): Q3KP58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 13, 2007
Last modified: June 24, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.