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O95473

- SNG4_HUMAN

UniProt

O95473 - SNG4_HUMAN

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Protein
Synaptogyrin-4
Gene
SYNGR4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptogyrin-4
Gene namesi
Name:SYNGR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:11502. SYNGR4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521Helical; Reviewed prediction
Add
BLAST
Transmembranei66 – 8621Helical; Reviewed prediction
Add
BLAST
Transmembranei104 – 12421Helical; Reviewed prediction
Add
BLAST
Transmembranei145 – 16521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36284.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Synaptogyrin-4
PRO_0000183998Add
BLAST

Proteomic databases

PaxDbiO95473.
PRIDEiO95473.

Expressioni

Gene expression databases

ArrayExpressiO95473.
BgeeiO95473.
CleanExiHS_SYNGR4.
GenevestigatoriO95473.

Organism-specific databases

HPAiHPA030075.
HPA059286.

Interactioni

Protein-protein interaction databases

BioGridi117090. 1 interaction.
STRINGi9606.ENSP00000344041.

Structurei

3D structure databases

ProteinModelPortaliO95473.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 169152MARVEL
Add
BLAST

Sequence similaritiesi

Belongs to the synaptogyrin family.
Contains 1 MARVEL domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG297575.
HOGENOMiHOG000220816.
HOVERGENiHBG098537.
InParanoidiO95473.
OMAiWIFQAYL.
OrthoDBiEOG7VTDQ1.
PhylomeDBiO95473.
TreeFamiTF320995.

Family and domain databases

InterProiIPR008253. Marvel.
IPR016579. Synaptogyrin.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PIRSFiPIRSF011282. Synaptogyrin. 1 hit.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95473-1 [UniParc]FASTAAdd to Basket

« Hide

MHIPKSLQEL ANSEAVQFLR RPKTITRVFE GVFSLIVFSS LLTDGYQNKM    50
ESPQLHCILN SNSVACSFAV GAGFLAFLSC LAFLVLDTQE TRIAGTRFKT 100
AFQLLDFILA VLWAVVWFMG FCFLANQWQH SPPKEFLLGS SSAQAAIAFT 150
FFSILVWIFQ AYLAFQDLRN DAPVPYKRFL DEGGMVLTTL PLPSANSPVN 200
MPTTGPNSLS YASSALSPCL TAPKSPRLAM MPDN 234
Length:234
Mass (Da):25,820
Last modified:November 13, 2007 - v2
Checksum:i1CE517E82E2ABDE0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271R → W.
Corresponds to variant rs919804 [ dbSNP | Ensembl ].
VAR_052245

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381F → I in CAA09754. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ011733 mRNA. Translation: CAA09754.1.
CH471177 Genomic DNA. Translation: EAW52339.1.
BC106891 mRNA. Translation: AAI06892.1.
CCDSiCCDS12717.1.
RefSeqiNP_036583.2. NM_012451.3.
XP_005258750.1. XM_005258693.1.
XP_005258751.1. XM_005258694.1.
UniGeneiHs.408333.

Genome annotation databases

EnsembliENST00000344846; ENSP00000344041; ENSG00000105467.
GeneIDi23546.
KEGGihsa:23546.
UCSCiuc002piz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ011733 mRNA. Translation: CAA09754.1 .
CH471177 Genomic DNA. Translation: EAW52339.1 .
BC106891 mRNA. Translation: AAI06892.1 .
CCDSi CCDS12717.1.
RefSeqi NP_036583.2. NM_012451.3.
XP_005258750.1. XM_005258693.1.
XP_005258751.1. XM_005258694.1.
UniGenei Hs.408333.

3D structure databases

ProteinModelPortali O95473.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117090. 1 interaction.
STRINGi 9606.ENSP00000344041.

Proteomic databases

PaxDbi O95473.
PRIDEi O95473.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344846 ; ENSP00000344041 ; ENSG00000105467 .
GeneIDi 23546.
KEGGi hsa:23546.
UCSCi uc002piz.3. human.

Organism-specific databases

CTDi 23546.
GeneCardsi GC19P048867.
HGNCi HGNC:11502. SYNGR4.
HPAi HPA030075.
HPA059286.
MIMi 608373. gene.
neXtProti NX_O95473.
PharmGKBi PA36284.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG297575.
HOGENOMi HOG000220816.
HOVERGENi HBG098537.
InParanoidi O95473.
OMAi WIFQAYL.
OrthoDBi EOG7VTDQ1.
PhylomeDBi O95473.
TreeFami TF320995.

Miscellaneous databases

GenomeRNAii 23546.
NextBioi 46080.
PROi O95473.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95473.
Bgeei O95473.
CleanExi HS_SYNGR4.
Genevestigatori O95473.

Family and domain databases

InterProi IPR008253. Marvel.
IPR016579. Synaptogyrin.
[Graphical view ]
Pfami PF01284. MARVEL. 1 hit.
[Graphical view ]
PIRSFi PIRSF011282. Synaptogyrin. 1 hit.
PROSITEi PS51225. MARVEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel member of synaptogyrin gene family."
    Kedra D., Dumanski J.P.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSNG4_HUMAN
AccessioniPrimary (citable) accession number: O95473
Secondary accession number(s): Q3KP58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 13, 2007
Last modified: July 9, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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