O95473 (SNG4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Synaptogyrin-4

Gene names

Name:

SYNGR4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	234 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the synaptogyrin family. Contains 1 MARVEL domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 234	234	Synaptogyrin-4		PRO_0000183998
Regions
	Transmembrane	25 – 45	21	Helical; Potential
	Transmembrane	66 – 86	21	Helical; Potential
	Transmembrane	104 – 124	21	Helical; Potential
	Transmembrane	145 – 165	21	Helical; Potential
	Domain	18 – 169	152	MARVEL
Natural variations
	Natural variant	27	1	R → W. Corresponds to variant rs919804 [ dbSNP | Ensembl ].		VAR_052245
Experimental info
	Sequence conflict	38	1	F → I in CAA09754. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O95473 [UniParc]. Last modified November 13, 2007. Version 2. Checksum: 1CE517E82E2ABDE0	FASTA	234	25,820
	10 20 30 40 50 60 MHIPKSLQEL ANSEAVQFLR RPKTITRVFE GVFSLIVFSS LLTDGYQNKM ESPQLHCILN 70 80 90 100 110 120 SNSVACSFAV GAGFLAFLSC LAFLVLDTQE TRIAGTRFKT AFQLLDFILA VLWAVVWFMG 130 140 150 160 170 180 FCFLANQWQH SPPKEFLLGS SSAQAAIAFT FFSILVWIFQ AYLAFQDLRN DAPVPYKRFL 190 200 210 220 230 DEGGMVLTTL PLPSANSPVN MPTTGPNSLS YASSALSPCL TAPKSPRLAM MPDN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a novel member of synaptogyrin gene family." Kedra D., Dumanski J.P. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ011733 mRNA. Translation: CAA09754.1. CH471177 Genomic DNA. Translation: EAW52339.1. BC106891 mRNA. Translation: AAI06892.1.
IPI	IPI00294757.
RefSeq	NP_036583.2. NM_012451.3.
UniGene	Hs.408333.
3D structure databases
ProteinModelPortal	O95473.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000344041.
Proteomic databases
PaxDb	O95473.
PRIDE	O95473.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000344846; ENSP00000344041; ENSG00000105467.
GeneID	23546.
KEGG	hsa:23546.
UCSC	uc002piz.3. human.
Organism-specific databases
CTD	23546.
GeneCards	GC19P048867.
HGNC	HGNC:11502. SYNGR4.
HPA	HPA030075.
MIM	608373. gene.
neXtProt	NX_O95473.
PharmGKB	PA36284.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG297575.
HOGENOM	HOG000220816.
HOVERGEN	HBG098537.
InParanoid	O95473.
OMA	APVPYKR.
OrthoDB	EOG4FJ89R.
PhylomeDB	O95473.
Gene expression databases
Bgee	O95473.
CleanEx	HS_SYNGR4.
Genevestigator	O95473.
GermOnline	ENSG00000105467. Homo sapiens.
Family and domain databases
InterPro	IPR008253. Marvel. IPR021128. MARVEL-like_dom. IPR016579. Synaptogyrin. [Graphical view]
Pfam	PF01284. MARVEL. 1 hit. [Graphical view]
PIRSF	PIRSF011282. Synaptogyrin. 1 hit.
PROSITE	PS51225. MARVEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23546.
NextBio	46080.
SOURCE	Search...

Entry information

Entry name

SNG4_HUMAN

Accession

Primary (citable) accession number: O95473
Secondary accession number(s): Q3KP58

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 13, 2007
Last modified:	April 3, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.