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O95473

- SNG4_HUMAN

UniProt

O95473 - SNG4_HUMAN

Protein

Synaptogyrin-4

Gene

SYNGR4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptogyrin-4
    Gene namesi
    Name:SYNGR4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:11502. SYNGR4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36284.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 234234Synaptogyrin-4PRO_0000183998Add
    BLAST

    Proteomic databases

    PaxDbiO95473.
    PRIDEiO95473.

    Expressioni

    Gene expression databases

    ArrayExpressiO95473.
    BgeeiO95473.
    CleanExiHS_SYNGR4.
    GenevestigatoriO95473.

    Organism-specific databases

    HPAiHPA030075.
    HPA059286.

    Interactioni

    Protein-protein interaction databases

    BioGridi117090. 1 interaction.
    STRINGi9606.ENSP00000344041.

    Structurei

    3D structure databases

    ProteinModelPortaliO95473.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei66 – 8621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 169152MARVELPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the synaptogyrin family.Curated
    Contains 1 MARVEL domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG297575.
    HOGENOMiHOG000220816.
    HOVERGENiHBG098537.
    InParanoidiO95473.
    OMAiWIFQAYL.
    OrthoDBiEOG7VTDQ1.
    PhylomeDBiO95473.
    TreeFamiTF320995.

    Family and domain databases

    InterProiIPR008253. Marvel.
    IPR016579. Synaptogyrin.
    [Graphical view]
    PfamiPF01284. MARVEL. 1 hit.
    [Graphical view]
    PIRSFiPIRSF011282. Synaptogyrin. 1 hit.
    PROSITEiPS51225. MARVEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95473-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHIPKSLQEL ANSEAVQFLR RPKTITRVFE GVFSLIVFSS LLTDGYQNKM    50
    ESPQLHCILN SNSVACSFAV GAGFLAFLSC LAFLVLDTQE TRIAGTRFKT 100
    AFQLLDFILA VLWAVVWFMG FCFLANQWQH SPPKEFLLGS SSAQAAIAFT 150
    FFSILVWIFQ AYLAFQDLRN DAPVPYKRFL DEGGMVLTTL PLPSANSPVN 200
    MPTTGPNSLS YASSALSPCL TAPKSPRLAM MPDN 234
    Length:234
    Mass (Da):25,820
    Last modified:November 13, 2007 - v2
    Checksum:i1CE517E82E2ABDE0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti38 – 381F → I in CAA09754. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti27 – 271R → W.
    Corresponds to variant rs919804 [ dbSNP | Ensembl ].
    VAR_052245

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ011733 mRNA. Translation: CAA09754.1.
    CH471177 Genomic DNA. Translation: EAW52339.1.
    BC106891 mRNA. Translation: AAI06892.1.
    CCDSiCCDS12717.1.
    RefSeqiNP_036583.2. NM_012451.3.
    XP_005258750.1. XM_005258693.1.
    XP_005258751.1. XM_005258694.1.
    UniGeneiHs.408333.

    Genome annotation databases

    EnsembliENST00000344846; ENSP00000344041; ENSG00000105467.
    GeneIDi23546.
    KEGGihsa:23546.
    UCSCiuc002piz.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ011733 mRNA. Translation: CAA09754.1 .
    CH471177 Genomic DNA. Translation: EAW52339.1 .
    BC106891 mRNA. Translation: AAI06892.1 .
    CCDSi CCDS12717.1.
    RefSeqi NP_036583.2. NM_012451.3.
    XP_005258750.1. XM_005258693.1.
    XP_005258751.1. XM_005258694.1.
    UniGenei Hs.408333.

    3D structure databases

    ProteinModelPortali O95473.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117090. 1 interaction.
    STRINGi 9606.ENSP00000344041.

    Proteomic databases

    PaxDbi O95473.
    PRIDEi O95473.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344846 ; ENSP00000344041 ; ENSG00000105467 .
    GeneIDi 23546.
    KEGGi hsa:23546.
    UCSCi uc002piz.3. human.

    Organism-specific databases

    CTDi 23546.
    GeneCardsi GC19P048867.
    HGNCi HGNC:11502. SYNGR4.
    HPAi HPA030075.
    HPA059286.
    MIMi 608373. gene.
    neXtProti NX_O95473.
    PharmGKBi PA36284.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG297575.
    HOGENOMi HOG000220816.
    HOVERGENi HBG098537.
    InParanoidi O95473.
    OMAi WIFQAYL.
    OrthoDBi EOG7VTDQ1.
    PhylomeDBi O95473.
    TreeFami TF320995.

    Miscellaneous databases

    GenomeRNAii 23546.
    NextBioi 46080.
    PROi O95473.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95473.
    Bgeei O95473.
    CleanExi HS_SYNGR4.
    Genevestigatori O95473.

    Family and domain databases

    InterProi IPR008253. Marvel.
    IPR016579. Synaptogyrin.
    [Graphical view ]
    Pfami PF01284. MARVEL. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF011282. Synaptogyrin. 1 hit.
    PROSITEi PS51225. MARVEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel member of synaptogyrin gene family."
      Kedra D., Dumanski J.P.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiSNG4_HUMAN
    AccessioniPrimary (citable) accession number: O95473
    Secondary accession number(s): Q3KP58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3