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O95473 (SNG4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptogyrin-4
Gene names
Name:SYNGR4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the synaptogyrin family.

Contains 1 MARVEL domain.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 234234Synaptogyrin-4
PRO_0000183998

Regions

Transmembrane25 – 4521Helical; Potential
Transmembrane66 – 8621Helical; Potential
Transmembrane104 – 12421Helical; Potential
Transmembrane145 – 16521Helical; Potential
Domain18 – 169152MARVEL

Natural variations

Natural variant271R → W.
Corresponds to variant rs919804 [ dbSNP | Ensembl ].
VAR_052245

Experimental info

Sequence conflict381F → I in CAA09754. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O95473 [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: 1CE517E82E2ABDE0

FASTA23425,820
        10         20         30         40         50         60 
MHIPKSLQEL ANSEAVQFLR RPKTITRVFE GVFSLIVFSS LLTDGYQNKM ESPQLHCILN 

        70         80         90        100        110        120 
SNSVACSFAV GAGFLAFLSC LAFLVLDTQE TRIAGTRFKT AFQLLDFILA VLWAVVWFMG 

       130        140        150        160        170        180 
FCFLANQWQH SPPKEFLLGS SSAQAAIAFT FFSILVWIFQ AYLAFQDLRN DAPVPYKRFL 

       190        200        210        220        230 
DEGGMVLTTL PLPSANSPVN MPTTGPNSLS YASSALSPCL TAPKSPRLAM MPDN 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a novel member of synaptogyrin gene family."
Kedra D., Dumanski J.P.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ011733 mRNA. Translation: CAA09754.1.
CH471177 Genomic DNA. Translation: EAW52339.1.
BC106891 mRNA. Translation: AAI06892.1.
RefSeqNP_036583.2. NM_012451.3.
XP_005258750.1. XM_005258693.1.
XP_005258751.1. XM_005258694.1.
UniGeneHs.408333.

3D structure databases

ProteinModelPortalO95473.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117090. 1 interaction.
STRING9606.ENSP00000344041.

Proteomic databases

PaxDbO95473.
PRIDEO95473.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000344846; ENSP00000344041; ENSG00000105467.
GeneID23546.
KEGGhsa:23546.
UCSCuc002piz.3. human.

Organism-specific databases

CTD23546.
GeneCardsGC19P048867.
HGNCHGNC:11502. SYNGR4.
HPAHPA030075.
HPA059286.
MIM608373. gene.
neXtProtNX_O95473.
PharmGKBPA36284.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG297575.
HOGENOMHOG000220816.
HOVERGENHBG098537.
InParanoidO95473.
OMAWIFQAYL.
OrthoDBEOG7VTDQ1.
PhylomeDBO95473.
TreeFamTF320995.

Gene expression databases

ArrayExpressO95473.
BgeeO95473.
CleanExHS_SYNGR4.
GenevestigatorO95473.

Family and domain databases

InterProIPR008253. Marvel.
IPR016579. Synaptogyrin.
[Graphical view]
PfamPF01284. MARVEL. 1 hit.
[Graphical view]
PIRSFPIRSF011282. Synaptogyrin. 1 hit.
PROSITEPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi23546.
NextBio46080.
PROO95473.
SOURCESearch...

Entry information

Entry nameSNG4_HUMAN
AccessionPrimary (citable) accession number: O95473
Secondary accession number(s): Q3KP58
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 13, 2007
Last modified: February 19, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM