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O95471

- CLD7_HUMAN

UniProt

O95471 - CLD7_HUMAN

Protein

Claudin-7

Gene

CLDN7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 4 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Plays a major role in tight junction-specific obliteration of the intercellular space.By similarity

    GO - Molecular functioni

    1. identical protein binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. structural molecule activity Source: InterPro

    GO - Biological processi

    1. calcium-independent cell-cell adhesion Source: UniProtKB

    Enzyme and pathway databases

    ReactomeiREACT_19373. Tight junction interactions.

    Protein family/group databases

    TCDBi1.H.1.1.2. the claudin tight junction (claudin) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Claudin-7
    Short name:
    CLDN-7
    Gene namesi
    Name:CLDN7
    Synonyms:CEPTRL2, CPETRL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:2049. CLDN7.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Lateral cell membrane. Cell junctiontight junction
    Note: Co-localizes with EPCAM at the lateral cell membrane and tight junction.

    GO - Cellular componenti

    1. integral component of membrane Source: ProtInc
    2. lateral plasma membrane Source: UniProtKB-SubCell
    3. tight junction Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26575.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 211211Claudin-7PRO_0000144750Add
    BLAST

    Post-translational modificationi

    Phosphorylated.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO95471.
    PaxDbiO95471.
    PRIDEiO95471.

    PTM databases

    PhosphoSiteiO95471.

    Expressioni

    Tissue specificityi

    Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.2 Publications

    Inductioni

    By androgens.1 Publication

    Gene expression databases

    ArrayExpressiO95471.
    BgeeiO95471.
    CleanExiHS_CLDN7.
    GenevestigatoriO95471.

    Organism-specific databases

    HPAiCAB013063.
    HPA014703.

    Interactioni

    Subunit structurei

    Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 By similarity. The phosphorylated form interacts with EPCAM.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TACSTD2P097582EBI-740744,EBI-4324738

    Protein-protein interaction databases

    BioGridi107758. 6 interactions.
    IntActiO95471. 3 interactions.
    MINTiMINT-1452252.
    STRINGi9606.ENSP00000353475.

    Structurei

    3D structure databases

    ProteinModelPortaliO95471.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77CytoplasmicSequence Analysis
    Topological domaini29 – 8153ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini103 – 11715CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini139 – 16022ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini182 – 21130CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei161 – 18121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni210 – 2112Interactions with TJP1, TJP2 and TJP3By similarity

    Sequence similaritiesi

    Belongs to the claudin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47316.
    HOGENOMiHOG000220937.
    HOVERGENiHBG000643.
    InParanoidiO95471.
    KOiK06087.
    OMAiYKGLWME.
    PhylomeDBiO95471.
    TreeFamiTF331936.

    Family and domain databases

    InterProiIPR006187. Claudin.
    IPR003552. Claudin7.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view]
    PANTHERiPTHR12002. PTHR12002. 1 hit.
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01077. CLAUDIN.
    PR01381. CLAUDIN7.
    PROSITEiPS01346. CLAUDIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95471-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MANSGLQLLG FSMALLGWVG LVACTAIPQW QMSSYAGDNI ITAQAMYKGL    50
    WMDCVTQSTG MMSCKMYDSV LALSAALQAT RALMVVSLVL GFLAMFVATM 100
    GMKCTRCGGD DKVKKARIAM GGGIIFIVAG LAALVACSWY GHQIVTDFYN 150
    PLIPTNIKYE FGPAIFIGWA GSALVILGGA LLSCSCPGNE SKAGYRVPRS 200
    YPKSNSSKEY V 211
    Length:211
    Mass (Da):22,418
    Last modified:November 2, 2010 - v4
    Checksum:i7F3CC1B963D9006A
    GO
    Isoform 2 (identifier: O95471-2) [UniParc]FASTAAdd to Basket

    Also known as: t-CLDN-7

    The sequence of this isoform differs from the canonical sequence as follows:
         159-211: Missing.

    Show »
    Length:158
    Mass (Da):16,837
    Checksum:i19E2D108C134F26E
    GO

    Sequence cautioni

    The sequence AAP97219.1 differs from that shown. Reason: Frameshift at positions 18 and 23.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201G → R in AAP97219. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti133 – 1331A → T.2 Publications
    Corresponds to variant rs17849410 [ dbSNP | Ensembl ].
    VAR_030736
    Natural varianti197 – 1971V → A.5 Publications
    Corresponds to variant rs4562 [ dbSNP | Ensembl ].
    VAR_014538

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei159 – 21153Missing in isoform 2. CuratedVSP_013230Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ011497 mRNA. Translation: CAA09626.1.
    AK313958 mRNA. Translation: BAG36674.1.
    BT006829 mRNA. Translation: AAP35475.1.
    AC003688 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90228.1.
    CH471108 Genomic DNA. Translation: EAW90229.1.
    BC001055 mRNA. Translation: AAH01055.1.
    BC071844 mRNA. Translation: AAH71844.1.
    AF093823 mRNA. Translation: AAP97219.1. Frameshift.
    CCDSiCCDS11096.1. [O95471-1]
    RefSeqiNP_001171951.1. NM_001185022.1. [O95471-1]
    NP_001171952.1. NM_001185023.1.
    NP_001298.3. NM_001307.5. [O95471-1]
    UniGeneiHs.513915.

    Genome annotation databases

    EnsembliENST00000360325; ENSP00000353475; ENSG00000181885. [O95471-1]
    ENST00000397317; ENSP00000396638; ENSG00000181885. [O95471-1]
    GeneIDi1366.
    KEGGihsa:1366.
    UCSCiuc002gfm.4. human. [O95471-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ011497 mRNA. Translation: CAA09626.1 .
    AK313958 mRNA. Translation: BAG36674.1 .
    BT006829 mRNA. Translation: AAP35475.1 .
    AC003688 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90228.1 .
    CH471108 Genomic DNA. Translation: EAW90229.1 .
    BC001055 mRNA. Translation: AAH01055.1 .
    BC071844 mRNA. Translation: AAH71844.1 .
    AF093823 mRNA. Translation: AAP97219.1 . Frameshift.
    CCDSi CCDS11096.1. [O95471-1 ]
    RefSeqi NP_001171951.1. NM_001185022.1. [O95471-1 ]
    NP_001171952.1. NM_001185023.1.
    NP_001298.3. NM_001307.5. [O95471-1 ]
    UniGenei Hs.513915.

    3D structure databases

    ProteinModelPortali O95471.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107758. 6 interactions.
    IntActi O95471. 3 interactions.
    MINTi MINT-1452252.
    STRINGi 9606.ENSP00000353475.

    Protein family/group databases

    TCDBi 1.H.1.1.2. the claudin tight junction (claudin) family.

    PTM databases

    PhosphoSitei O95471.

    Proteomic databases

    MaxQBi O95471.
    PaxDbi O95471.
    PRIDEi O95471.

    Protocols and materials databases

    DNASUi 1366.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360325 ; ENSP00000353475 ; ENSG00000181885 . [O95471-1 ]
    ENST00000397317 ; ENSP00000396638 ; ENSG00000181885 . [O95471-1 ]
    GeneIDi 1366.
    KEGGi hsa:1366.
    UCSCi uc002gfm.4. human. [O95471-1 ]

    Organism-specific databases

    CTDi 1366.
    GeneCardsi GC17M007163.
    HGNCi HGNC:2049. CLDN7.
    HPAi CAB013063.
    HPA014703.
    MIMi 609131. gene.
    neXtProti NX_O95471.
    PharmGKBi PA26575.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47316.
    HOGENOMi HOG000220937.
    HOVERGENi HBG000643.
    InParanoidi O95471.
    KOi K06087.
    OMAi YKGLWME.
    PhylomeDBi O95471.
    TreeFami TF331936.

    Enzyme and pathway databases

    Reactomei REACT_19373. Tight junction interactions.

    Miscellaneous databases

    GeneWikii CLDN7.
    GenomeRNAii 1366.
    NextBioi 5535.
    PROi O95471.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95471.
    Bgeei O95471.
    CleanExi HS_CLDN7.
    Genevestigatori O95471.

    Family and domain databases

    InterProi IPR006187. Claudin.
    IPR003552. Claudin7.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view ]
    PANTHERi PTHR12002. PTHR12002. 1 hit.
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01077. CLAUDIN.
    PR01381. CLAUDIN7.
    PROSITEi PS01346. CLAUDIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Keen T.J.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-197.
      Tissue: Colon adenocarcinoma.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-197.
      Tissue: Colon.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS THR-133 AND ALA-197.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS THR-133 AND ALA-197.
      Tissue: Mammary gland and Placenta.
    7. "Cloning and expression of a novel human cDNA homology to murine claudin-1 mRNA."
      Yue P., Yu L., Bi A.D., Zhang M., He H., Zhao S.Y.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-211 (ISOFORM 1), VARIANT ALA-197.
    8. "Regulation of the expression of the prostate-specific antigen by claudin-7."
      Zheng J.-Y., Yu D., Foroohar M., Ko E., Chan J., Kim N., Chiu R., Pang S.
      J. Membr. Biol. 194:187-197(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.
    9. "Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast."
      Kominsky S.L., Argani P., Korz D., Evron E., Raman V., Garrett E., Rein A., Sauter G., Kallioniemi O.-P., Sukumar S.
      Oncogene 22:2021-2033(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    10. "The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7."
      Ladwein M., Pape U.F., Schmidt D.S., Schnoelzer M., Fiedler S., Langbein L., Franke W.W., Moldenhauer G., Zoeller M.
      Exp. Cell Res. 309:345-357(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION, INTERACTION WITH EPCAM.

    Entry informationi

    Entry nameiCLD7_HUMAN
    AccessioniPrimary (citable) accession number: O95471
    Secondary accession number(s): B2R9X7
    , D3DTP0, Q6IPN3, Q7Z4Y7, Q9BVN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 127 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3