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O95471 (CLD7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Claudin-7

Short name=CLDN-7
Gene names
Name:CLDN7
Synonyms:CEPTRL2, CPETRL2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a major role in tight junction-specific obliteration of the intercellular space By similarity.

Subunit structure

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 By similarity. The phosphorylated form interacts with EPCAM. Ref.10

Subcellular location

Cell membrane; Multi-pass membrane protein. Lateral cell membrane. Cell junctiontight junction. Note: Co-localizes with EPCAM at the lateral cell membrane and tight junction. Ref.8 Ref.9 Ref.10

Tissue specificity

Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions. Ref.8 Ref.9

Induction

By androgens. Ref.8

Post-translational modification

Phosphorylated. Ref.10

Sequence similarities

Belongs to the claudin family.

Sequence caution

The sequence AAP97219.1 differs from that shown. Reason: Frameshift at positions 18 and 23.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TACSTD2P097582EBI-740744,EBI-4324738

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O95471-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O95471-2)

Also known as: t-CLDN-7;

The sequence of this isoform differs from the canonical sequence as follows:
     159-211: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 211211Claudin-7
PRO_0000144750

Regions

Topological domain1 – 77Cytoplasmic Potential
Transmembrane8 – 2821Helical; Potential
Topological domain29 – 8153Extracellular Potential
Transmembrane82 – 10221Helical; Potential
Topological domain103 – 11715Cytoplasmic Potential
Transmembrane118 – 13821Helical; Potential
Topological domain139 – 16022Extracellular Potential
Transmembrane161 – 18121Helical; Potential
Topological domain182 – 21130Cytoplasmic Potential
Region210 – 2112Interactions with TJP1, TJP2 and TJP3 By similarity

Natural variations

Alternative sequence159 – 21153Missing in isoform 2.
VSP_013230
Natural variant1331A → T. Ref.3 Ref.6
Corresponds to variant rs17849410 [ dbSNP | Ensembl ].
VAR_030736
Natural variant1971V → A. Ref.1 Ref.2 Ref.3 Ref.6 Ref.7
Corresponds to variant rs4562 [ dbSNP | Ensembl ].
VAR_014538

Experimental info

Sequence conflict201G → R in AAP97219. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 2, 2010. Version 4.
Checksum: 7F3CC1B963D9006A

FASTA21122,418
        10         20         30         40         50         60 
MANSGLQLLG FSMALLGWVG LVACTAIPQW QMSSYAGDNI ITAQAMYKGL WMDCVTQSTG 

        70         80         90        100        110        120 
MMSCKMYDSV LALSAALQAT RALMVVSLVL GFLAMFVATM GMKCTRCGGD DKVKKARIAM 

       130        140        150        160        170        180 
GGGIIFIVAG LAALVACSWY GHQIVTDFYN PLIPTNIKYE FGPAIFIGWA GSALVILGGA 

       190        200        210 
LLSCSCPGNE SKAGYRVPRS YPKSNSSKEY V 

« Hide

Isoform 2 (t-CLDN-7) [UniParc].

Checksum: 19E2D108C134F26E
Show »

FASTA15816,837

References

« Hide 'large scale' references
[1]Keen T.J.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-197.
Tissue: Colon adenocarcinoma.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-197.
Tissue: Colon.
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS THR-133 AND ALA-197.
[4]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS THR-133 AND ALA-197.
Tissue: Mammary gland and Placenta.
[7]"Cloning and expression of a novel human cDNA homology to murine claudin-1 mRNA."
Yue P., Yu L., Bi A.D., Zhang M., He H., Zhao S.Y.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-211 (ISOFORM 1), VARIANT ALA-197.
[8]"Regulation of the expression of the prostate-specific antigen by claudin-7."
Zheng J.-Y., Yu D., Foroohar M., Ko E., Chan J., Kim N., Chiu R., Pang S.
J. Membr. Biol. 194:187-197(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.
[9]"Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast."
Kominsky S.L., Argani P., Korz D., Evron E., Raman V., Garrett E., Rein A., Sauter G., Kallioniemi O.-P., Sukumar S.
Oncogene 22:2021-2033(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[10]"The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7."
Ladwein M., Pape U.F., Schmidt D.S., Schnoelzer M., Fiedler S., Langbein L., Franke W.W., Moldenhauer G., Zoeller M.
Exp. Cell Res. 309:345-357(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION, INTERACTION WITH EPCAM.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ011497 mRNA. Translation: CAA09626.1.
AK313958 mRNA. Translation: BAG36674.1.
BT006829 mRNA. Translation: AAP35475.1.
AC003688 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90228.1.
CH471108 Genomic DNA. Translation: EAW90229.1.
BC001055 mRNA. Translation: AAH01055.1.
BC071844 mRNA. Translation: AAH71844.1.
AF093823 mRNA. Translation: AAP97219.1. Frameshift.
CCDSCCDS11096.1. [O95471-1]
RefSeqNP_001171951.1. NM_001185022.1. [O95471-1]
NP_001171952.1. NM_001185023.1.
NP_001298.3. NM_001307.5. [O95471-1]
UniGeneHs.513915.

3D structure databases

ProteinModelPortalO95471.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107758. 6 interactions.
IntActO95471. 3 interactions.
MINTMINT-1452252.
STRING9606.ENSP00000353475.

Protein family/group databases

TCDB1.H.1.1.2. the claudin tight junction (claudin) family.

PTM databases

PhosphoSiteO95471.

Proteomic databases

MaxQBO95471.
PaxDbO95471.
PRIDEO95471.

Protocols and materials databases

DNASU1366.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360325; ENSP00000353475; ENSG00000181885. [O95471-1]
ENST00000397317; ENSP00000396638; ENSG00000181885. [O95471-1]
GeneID1366.
KEGGhsa:1366.
UCSCuc002gfm.4. human. [O95471-1]

Organism-specific databases

CTD1366.
GeneCardsGC17M007163.
HGNCHGNC:2049. CLDN7.
HPACAB013063.
HPA014703.
MIM609131. gene.
neXtProtNX_O95471.
PharmGKBPA26575.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47316.
HOGENOMHOG000220937.
HOVERGENHBG000643.
InParanoidO95471.
KOK06087.
OMAYKGLWME.
PhylomeDBO95471.
TreeFamTF331936.

Enzyme and pathway databases

ReactomeREACT_111155. Cell-Cell communication.

Gene expression databases

ArrayExpressO95471.
BgeeO95471.
CleanExHS_CLDN7.
GenevestigatorO95471.

Family and domain databases

InterProIPR006187. Claudin.
IPR003552. Claudin7.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERPTHR12002. PTHR12002. 1 hit.
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSPR01077. CLAUDIN.
PR01381. CLAUDIN7.
PROSITEPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCLDN7.
GenomeRNAi1366.
NextBio5535.
PROO95471.
SOURCESearch...

Entry information

Entry nameCLD7_HUMAN
AccessionPrimary (citable) accession number: O95471
Secondary accession number(s): B2R9X7 expand/collapse secondary AC list , D3DTP0, Q6IPN3, Q7Z4Y7, Q9BVN0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 125 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM