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Reviewed, UniProtKB/Swiss-Prot O95471 (CLD7_HUMAN)

Last modified November 25, 2008. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Claudin-7
      Short name=CLDN-7
Gene names
Name: CLDN7
Synonyms: CEPTRL2, CPETRL2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Plays a major role in tight junction-specific obliteration of the intercellular space By similarity.

Subunit structure

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 By similarity.

Subcellular location

Cell junctiontight junction. Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.

Induction

By androgens.

Sequence similarities

Belongs to the claudin family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O95471-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O95471-2)

Also known as: t-CLDN-7;

The sequence of this isoform differs from the canonical sequence as follows:
     159-211: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 211211Claudin-7
PRO_0000144750

Regions

Topological domain1 – 77Cytoplasmic Potential
Transmembrane8 – 2821 Potential
Topological domain29 – 8153Extracellular Potential
Transmembrane82 – 10221 Potential
Topological domain103 – 11715Cytoplasmic Potential
Transmembrane118 – 13821 Potential
Topological domain139 – 16022Extracellular Potential
Transmembrane161 – 18121 Potential
Topological domain182 – 21130Cytoplasmic Potential
Region210 – 2112Interactions with TJP1, TJP2 and TJP3 By similarity

Natural variations

Alternative sequence159 – 21153Missing in isoform 2.
VSP_013230
Natural variant1331A → T: dbSNP rs17849410.
VAR_030736
Natural variant1971A → V: dbSNP rs4562.
VAR_014538

Experimental info

Sequence conflict18 – 236WVGLVA → GCVSWL in AAP97219. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 29, 2005. Version 3.
Checksum: 7F3CC1B963D912E1

FASTA21122,390
        10         20         30         40         50         60 
MANSGLQLLG FSMALLGWVG LVACTAIPQW QMSSYAGDNI ITAQAMYKGL WMDCVTQSTG 

        70         80         90        100        110        120 
MMSCKMYDSV LALSAALQAT RALMVVSLVL GFLAMFVATM GMKCTRCGGD DKVKKARIAM 

       130        140        150        160        170        180 
GGGIIFIVAG LAALVACSWY GHQIVTDFYN PLIPTNIKYE FGPAIFIGWA GSALVILGGA 

       190        200        210 
LLSCSCPGNE SKAGYRAPRS YPKSNSSKEY V 

« Hide

Isoform 2 (t-CLDN-7) [UniParc].

Checksum: 19E2D108C134F26E
Show »

15816,837

References

« Hide 'large scale' references
[1]Keen T.J.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Colon adenocarcinoma.
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-133.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS THR-133 AND VAL-197.
Tissue: Mammary gland and Placenta.
[4]"Cloning and expression of a novel human cDNA homology to murine claudin-1 mRNA."
Yue P., Yu L., Bi A.D., Zhang M., He H., Zhao S.Y.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-211 (ISOFORM 1).
[5]"Regulation of the expression of the prostate-specific antigen by claudin-7."
Zheng J.-Y., Yu D., Foroohar M., Ko E., Chan J., Kim N., Chiu R., Pang S.
J. Membr. Biol. 194:187-197(2003) [PubMed: 14502431] [Abstract]
Cited for: ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.
[6]"Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast."
Kominsky S.L., Argani P., Korz D., Evron E., Raman V., Garrett E., Rein A., Sauter G., Kallioniemi O.-P., Sukumar S.
Oncogene 22:2021-2033(2003) [PubMed: 12673207] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

AJ011497 mRNA. Translation: CAA09626.1.
BT006829 mRNA. Translation: AAP35475.1.
BC001055 mRNA. Translation: AAH01055.1.
BC071844 mRNA. Translation: AAH71844.1.
AF093823 mRNA. Translation: AAP97219.1.
RefSeqNP_001298.3.
UniGeneHs.513915

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActO95471.

PTM databases

PhosphoSiteO95471.

Genome annotation databases

EnsemblENSG00000181885. Homo sapiens. [Contig view]
GeneID1366.
KEGGhsa:1366.

Organism-specific databases

H-InvDBHIX0013110.
HGNCHGNC:2049. CLDN7.
HPACAB013063.
HPA014703.
MIM609131. gene.
PharmGKBPA26575.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMO95471.
HOVERGENO95471.

Gene expression databases

CleanExHS_CLDN7.
GermOnlineENSG00000181885. Homo sapiens.

Family and domain databases

InterProIPR006187. Claudin.
IPR003552. Claudin7.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERPTHR12002. Claudin. 1 hit.
PTHR12002:SF30. Claudin7. 1 hit.
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSPR01077. CLAUDIN.
PR01381. CLAUDIN7.
PROSITEPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

LinkHubO95471.
NextBio5535.
SOURCESearch...

Entry information

Entry nameCLD7_HUMAN
AccessionPrimary (citable) accession number: O95471
Secondary accession number(s): Q6IPN3, Q7Z4Y7, Q9BVN0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 29, 2005
Last modified: November 25, 2008
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents