O95466 (FMNL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formin-like protein 1

Alternative name(s):
CLL-associated antigen KW-13
Leukocyte formin

Gene names

Name:	FMNL1
Synonyms:	C17orf1, C17orf1B, FMNL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1100 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in the control of cell motility and survival of macrophages By similarity. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Ref.13
Subunit structure	Interacts with RAC1, PFN1 and PFN2 By similarity. Interacts (activated by RAC1) with SRGAP2 (via SH3 domain); regulates the actin filament severing activity of FMNL1. Ref.15
Subcellular location	Cytoplasm By similarity. Cell membrane; Lipid-anchor. Cytoplasmic vesicle › phagosome By similarity. Note: Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1 By similarity. Ref.7 Isoform 3: Cytoplasm › cell cortex. Cell projection › bleb. Note: Colocalized with F-actin in bleb protrusions. Ref.7
Tissue specificity	Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Domain	The DAD domain regulates activation via by an autoinhibitory interaction with the N-terminus. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments By similarity.
Post-translational modification	Myristoylation mediates membrane localization and blebbing.
Sequence similarities	Belongs to the formin homology family. Contains 1 DAD (diaphanous autoregulatory) domain. Contains 1 FH2 (formin homology 2) domain. Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
Sequence caution	The sequence AAH21906.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA07870.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Cell projection Cytoplasm Cytoplasmic vesicle Membrane
Coding sequence diversity	Alternative splicing
PTM	Lipoprotein Myristate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin filament severing Inferred from sequence or structural similarity. Source: UniProtKB cortical actin cytoskeleton organization Inferred from mutant phenotype Ref.13. Source: UniProtKB regulation of cell shape Inferred from mutant phenotype Ref.13. Source: UniProtKB substrate-dependent cell migration Inferred from electronic annotation. Source: Compara
Cellular_component	bleb Inferred from electronic annotation. Source: UniProtKB-SubCell cell cortex Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Inferred from sequence or structural similarity. Source: UniProtKB phagocytic vesicle Inferred from sequence or structural similarity. Source: UniProtKB plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	GTPase activating protein binding Inferred from direct assay Ref.15. Source: UniProtKB Rac GTPase binding Inferred from sequence or structural similarity. Source: UniProtKB actin filament binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SRGAP2	O75044	3	EBI-720020,EBI-1051034

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O95466-1)

Also known as: FMNL1alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O95466-2)

Also known as: FMNL1beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1071-1100: VIKTVPFTARTGKRTSRLLCEASLGEEMPL → DLRNQPYIRADTGRRSARRRPPGPPLQVTSDLSL

Isoform 3 (identifier: O95466-3)

Also known as: FMNL1gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     1070-1070: T → TGKGLARPWSYPQSVLLCFLLTQCAILWGTGCHTASCYLFCFSFLFPFSTPLHLPHPHS

Note: Due to intron retention. Constitutively activated form, probably due to alterations in the DAD domain.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1100	1100	Formin-like protein 1		PRO_0000194890
Regions
	Domain	27 – 468	442	GBD/FH3
	Domain	632 – 1023	392	FH2
	Domain	1059 – 1090	32	DAD
	Compositional bias	459 – 616	158	Pro-rich
Amino acid modifications
	Modified residue	7	1	Phosphoserine Ref.11
	Modified residue	184	1	Phosphoserine Ref.9 Ref.11 Ref.12
	Modified residue	624	1	Phosphoserine Ref.8 Ref.9 Ref.11 Ref.12
	Lipidation	2	1	N-myristoyl glycine Ref.7
Natural variations
	Alternative sequence	1070	1	T → TGKGLARPWSYPQSVLLCFL LTQCAILWGTGCHTASCYLF CFSFLFPFSTPLHLPHPHS in isoform 3.		VSP_043845
	Alternative sequence	1071 – 1100	30	VIKTV…EEMPL → DLRNQPYIRADTGRRSARRR PPGPPLQVTSDLSL in isoform 2.		VSP_013977
Experimental info
	Sequence conflict	455	1	P → A in AAP32476. Ref.1
	Sequence conflict	455	1	P → A in AAL99920. Ref.3
	Sequence conflict	455	1	P → A in AAH73988. Ref.4
	Sequence conflict	602	1	Missing in AAH21906. Ref.4
	Sequence conflict	629	1	G → R in CAA07870. Ref.5
Isoform 2:
	Sequence conflict	1101 – 1102	2	DL → EV in AAH21906. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (FMNL1alpha) [UniParc]. Last modified June 16, 2009. Version 3. Checksum: 91F9CE2B3B526FFC	FASTA	1,100	121,854
	10 20 30 40 50 60 MGNAAGSAEQ PAGPAAPPPK QPAPPKQPMP AAGELEERFN RALNCMNLPP DKVQLLSQYD 70 80 90 100 110 120 NEKKWELICD QERFQVKNPP AAYIQKLKSY VDTGGVSRKV AADWMSNLGF KRRVQESTQV 130 140 150 160 170 180 LRELETSLRT NHIGWVQEFL NEENRGLDVL LEYLAFAQCS VTYDMESTDN GASNSEKNKP 190 200 210 220 230 240 LEQSVEDLSK GPPSSVPKSR HLTIKLTPAH SRKALRNSRI VSQKDDVHVC IMCLRAIMNY 250 260 270 280 290 300 QSGFSLVMNH PACVNEIALS LNNKNPRTKA LVLELLAAVC LVRGGHDIIL AAFDNFKEVC 310 320 330 340 350 360 GEQHRFEKLM EYFRNEDSNI DFMVACMQFI NIVVHSVENM NFRVFLQYEF THLGLDLYLE 370 380 390 400 410 420 RLRLTESDKL QVQIQAYLDN IFDVGALLED TETKNAVLEH MEELQEQVAL LTERLRDAEN 430 440 450 460 470 480 ESMAKIAELE KQLSQARKEL ETLRERFSES TAMGPSRRPP EPEKAPPAAP TRPSALELKV 490 500 510 520 530 540 EELEEKGLIR ILRGPGDAVS IEILPVAVAT PSGGDAPTPG VPTGSPSPDL APAAEPAPGA 550 560 570 580 590 600 APPPPPPLPG LPSPQEAPPS APPQAPPLPG SPEPPPAPPL PGDLPPPPPP PPPPPGTDGP 610 620 630 640 650 660 VPPPPPPPPP PPGGPPDALG RRDSELGPGV KAKKPIQTKF RMPLLNWVAL KPSQITGTVF 670 680 690 700 710 720 TELNDEKVLQ ELDMSDFEEQ FKTKSQGPSL DLSALKSKAA QKAPSKATLI EANRAKNLAI 730 740 750 760 770 780 TLRKGNLGAE RICQAIEAYD LQALGLDFLE LLMRFLPTEY ERSLITRFER EQRPMEELSE 790 800 810 820 830 840 EDRFMLCFSR IPRLPERMTT LTFLGNFPDT AQLLMPQLNA IIAASMSIKS SDKLRQILEI 850 860 870 880 890 900 VLAFGNYMNS SKRGAAYGFR LQSLDALLEM KSTDRKQTLL HYLVKVIAEK YPQLTGFHSD 910 920 930 940 950 960 LHFLDKAGSV SLDSVLADVR SLQRGLELTQ REFVRQDDCM VLKEFLRANS PTMDKLLADS 970 980 990 1000 1010 1020 KTAQEAFESV VEYFGENPKT TSPGLFFSLF SRFIKAYKKA EQEVEQWKKE AAAQEAGADT 1030 1040 1050 1060 1070 1080 PGKGEPPAPK SPPKARRPQM DLISELKRRQ QKEPLIYESD RDGAIEDIIT VIKTVPFTAR 1090 1100 TGKRTSRLLC EASLGEEMPL
	Isoform 2 (FMNL1beta) [UniParc]. Checksum: 74CFC7C3D5ABCC23	FASTA	1,104	122,409
	10 20 30 40 50 60 MGNAAGSAEQ PAGPAAPPPK QPAPPKQPMP AAGELEERFN RALNCMNLPP DKVQLLSQYD 70 80 90 100 110 120 NEKKWELICD QERFQVKNPP AAYIQKLKSY VDTGGVSRKV AADWMSNLGF KRRVQESTQV 130 140 150 160 170 180 LRELETSLRT NHIGWVQEFL NEENRGLDVL LEYLAFAQCS VTYDMESTDN GASNSEKNKP 190 200 210 220 230 240 LEQSVEDLSK GPPSSVPKSR HLTIKLTPAH SRKALRNSRI VSQKDDVHVC IMCLRAIMNY 250 260 270 280 290 300 QSGFSLVMNH PACVNEIALS LNNKNPRTKA LVLELLAAVC LVRGGHDIIL AAFDNFKEVC 310 320 330 340 350 360 GEQHRFEKLM EYFRNEDSNI DFMVACMQFI NIVVHSVENM NFRVFLQYEF THLGLDLYLE 370 380 390 400 410 420 RLRLTESDKL QVQIQAYLDN IFDVGALLED TETKNAVLEH MEELQEQVAL LTERLRDAEN 430 440 450 460 470 480 ESMAKIAELE KQLSQARKEL ETLRERFSES TAMGPSRRPP EPEKAPPAAP TRPSALELKV 490 500 510 520 530 540 EELEEKGLIR ILRGPGDAVS IEILPVAVAT PSGGDAPTPG VPTGSPSPDL APAAEPAPGA 550 560 570 580 590 600 APPPPPPLPG LPSPQEAPPS APPQAPPLPG SPEPPPAPPL PGDLPPPPPP PPPPPGTDGP 610 620 630 640 650 660 VPPPPPPPPP PPGGPPDALG RRDSELGPGV KAKKPIQTKF RMPLLNWVAL KPSQITGTVF 670 680 690 700 710 720 TELNDEKVLQ ELDMSDFEEQ FKTKSQGPSL DLSALKSKAA QKAPSKATLI EANRAKNLAI 730 740 750 760 770 780 TLRKGNLGAE RICQAIEAYD LQALGLDFLE LLMRFLPTEY ERSLITRFER EQRPMEELSE 790 800 810 820 830 840 EDRFMLCFSR IPRLPERMTT LTFLGNFPDT AQLLMPQLNA IIAASMSIKS SDKLRQILEI 850 860 870 880 890 900 VLAFGNYMNS SKRGAAYGFR LQSLDALLEM KSTDRKQTLL HYLVKVIAEK YPQLTGFHSD 910 920 930 940 950 960 LHFLDKAGSV SLDSVLADVR SLQRGLELTQ REFVRQDDCM VLKEFLRANS PTMDKLLADS 970 980 990 1000 1010 1020 KTAQEAFESV VEYFGENPKT TSPGLFFSLF SRFIKAYKKA EQEVEQWKKE AAAQEAGADT 1030 1040 1050 1060 1070 1080 PGKGEPPAPK SPPKARRPQM DLISELKRRQ QKEPLIYESD RDGAIEDIIT DLRNQPYIRA 1090 1100 DTGRRSARRR PPGPPLQVTS DLSL
	Isoform 3 (FMNL1gamma) [UniParc]. Checksum: 43D0BA60ABEA6AD5	FASTA	1,158	128,335
	10 20 30 40 50 60 MGNAAGSAEQ PAGPAAPPPK QPAPPKQPMP AAGELEERFN RALNCMNLPP DKVQLLSQYD 70 80 90 100 110 120 NEKKWELICD QERFQVKNPP AAYIQKLKSY VDTGGVSRKV AADWMSNLGF KRRVQESTQV 130 140 150 160 170 180 LRELETSLRT NHIGWVQEFL NEENRGLDVL LEYLAFAQCS VTYDMESTDN GASNSEKNKP 190 200 210 220 230 240 LEQSVEDLSK GPPSSVPKSR HLTIKLTPAH SRKALRNSRI VSQKDDVHVC IMCLRAIMNY 250 260 270 280 290 300 QSGFSLVMNH PACVNEIALS LNNKNPRTKA LVLELLAAVC LVRGGHDIIL AAFDNFKEVC 310 320 330 340 350 360 GEQHRFEKLM EYFRNEDSNI DFMVACMQFI NIVVHSVENM NFRVFLQYEF THLGLDLYLE 370 380 390 400 410 420 RLRLTESDKL QVQIQAYLDN IFDVGALLED TETKNAVLEH MEELQEQVAL LTERLRDAEN 430 440 450 460 470 480 ESMAKIAELE KQLSQARKEL ETLRERFSES TAMGPSRRPP EPEKAPPAAP TRPSALELKV 490 500 510 520 530 540 EELEEKGLIR ILRGPGDAVS IEILPVAVAT PSGGDAPTPG VPTGSPSPDL APAAEPAPGA 550 560 570 580 590 600 APPPPPPLPG LPSPQEAPPS APPQAPPLPG SPEPPPAPPL PGDLPPPPPP PPPPPGTDGP 610 620 630 640 650 660 VPPPPPPPPP PPGGPPDALG RRDSELGPGV KAKKPIQTKF RMPLLNWVAL KPSQITGTVF 670 680 690 700 710 720 TELNDEKVLQ ELDMSDFEEQ FKTKSQGPSL DLSALKSKAA QKAPSKATLI EANRAKNLAI 730 740 750 760 770 780 TLRKGNLGAE RICQAIEAYD LQALGLDFLE LLMRFLPTEY ERSLITRFER EQRPMEELSE 790 800 810 820 830 840 EDRFMLCFSR IPRLPERMTT LTFLGNFPDT AQLLMPQLNA IIAASMSIKS SDKLRQILEI 850 860 870 880 890 900 VLAFGNYMNS SKRGAAYGFR LQSLDALLEM KSTDRKQTLL HYLVKVIAEK YPQLTGFHSD 910 920 930 940 950 960 LHFLDKAGSV SLDSVLADVR SLQRGLELTQ REFVRQDDCM VLKEFLRANS PTMDKLLADS 970 980 990 1000 1010 1020 KTAQEAFESV VEYFGENPKT TSPGLFFSLF SRFIKAYKKA EQEVEQWKKE AAAQEAGADT 1030 1040 1050 1060 1070 1080 PGKGEPPAPK SPPKARRPQM DLISELKRRQ QKEPLIYESD RDGAIEDIIT GKGLARPWSY 1090 1100 1110 1120 1130 1140 PQSVLLCFLL TQCAILWGTG CHTASCYLFC FSFLFPFSTP LHLPHPHSVI KTVPFTARTG 1150 KRTSRLLCEA SLGEEMPL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human leukocyte formin: a new protein preferentially expressed in lymphocytes." Favaro P.M.B., Medina S.S., Basseres D.S., Costa F.F., Saad S.T.O. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Bone marrow.
[2]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Identification of novel tumor antigens in CLL by SEREX: assessment of their potential as targets for immunotherapeutic approaches." Krackhardt A.M., Witzens M., Harig S., Hodi F.S., Zauls A.J., Chessia M., Barrett P., Gribben J.G. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 110-1100 (ISOFORM 1).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 419-1100 (ISOFORMS 1 AND 2). Tissue: Brain and Lymph.
[5]	"The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17." Aronsson F.C., Magnusson P., Andersson B., Karsten S.L., Shibasaki Y., Lendon C.L., Goate A.M., Brookes A.J. Hum. Genet. 103:340-345(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 629-1100 (ISOFORM 2).
[6]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 642-1100 (ISOFORM 2).
[7]	"Formin-like 1 (FMNL1) is regulated by N-terminal myristoylation and induces polarized membrane blebbing." Han Y., Eppinger E., Schuster I.G., Weigand L.U., Liang X., Kremmer E., Peschel C., Krackhardt A.M. J. Biol. Chem. 284:33409-33417(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 668-1100 (ISOFORM 3), MYRISTOYLATION AT GLY-2, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-624, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184 AND SER-624, MASS SPECTROMETRY. Tissue: T-cell.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7; SER-184 AND SER-624, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[12]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184 AND SER-624, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration." Bai S.W., Herrera-Abreu M.T., Rohn J.L., Racine V., Tajadura V., Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J. BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"Bi-modal regulation of a formin by srGAP2." Mason F.M., Heimsath E.G., Higgs H.N., Soderling S.H. J. Biol. Chem. 286:6577-6586(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SRGAP2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY278319 mRNA. Translation: AAP32476.1. AC008105 mRNA. No translation available. AF432213 mRNA. Translation: AAL99920.1. BC001710 mRNA. Translation: AAH01710.2. BC009000 mRNA. Translation: AAH09000.2. BC021906 mRNA. Translation: AAH21906.1. Different initiation. BC073988 mRNA. Translation: AAH73988.1. AJ008112 mRNA. Translation: CAA07870.1. Different initiation. CR456759 mRNA. Translation: CAG33040.1. FJ534522 mRNA. Translation: ACR19333.1.
IPI	IPI00025202. IPI00163516. IPI00954929.
RefSeq	NP_005883.2. NM_005892.3.
UniGene	Hs.100217.
3D structure databases
ProteinModelPortal	O95466.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95466. 3 interactions.
MINT	MINT-1188250.
STRING	9606.ENSP00000329219.
PTM databases
PhosphoSite	O95466.
Proteomic databases
PaxDb	O95466.
PRIDE	O95466.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328118; ENSP00000327442; ENSG00000184922. ENST00000331495; ENSP00000329219; ENSG00000184922.
GeneID	752.
KEGG	hsa:752.
UCSC	uc002iin.3. human. uc002iiq.3. human.
Organism-specific databases
CTD	752.
GeneCards	GC17P043299.
HGNC	HGNC:1212. FMNL1.
HPA	HPA008129. HPA028288.
MIM	604656. gene.
neXtProt	NX_O95466.
PharmGKB	PA28186.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG149898.
HOVERGEN	HBG053118.
OMA	QLTGFHS.
PhylomeDB	O95466.
Gene expression databases
Bgee	O95466.
CleanEx	HS_FMNL1.
Genevestigator	O95466.
GermOnline	ENSG00000184922. Homo sapiens.
Family and domain databases
InterPro	IPR003104. Actin-bd_FH2/DRF_autoreg. IPR016024. ARM-type_fold. IPR014767. Diaphanous_autoregulatory. IPR010472. Drf_FH3. IPR010473. Drf_GTPase-bd. IPR015425. FH2_actin-bd. IPR014768. GTPase-bd/formin_homology_3. [Graphical view]
Pfam	PF06367. Drf_FH3. 1 hit. PF06371. Drf_GBD. 2 hits. PF02181. FH2. 1 hit. [Graphical view]
SMART	SM00498. FH2. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF101447. FH2_actin_bd. 1 hit.
PROSITE	PS51231. DAD. 1 hit. PS51444. FH2. 1 hit. PS51232. GBD_FH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	752.
NextBio	3034.
SOURCE	Search...

Entry information

Entry name

FMNL_HUMAN

Accession

Primary (citable) accession number: O95466
Secondary accession number(s): D2DGW2 , Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	June 16, 2009
Last modified:	May 1, 2013
This is version 113 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.