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Protein

Proteasome assembly chaperone 1

Gene

PSMG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome assembly chaperone 1
Short name:
PAC-1
Alternative name(s):
Chromosome 21 leucine-rich protein
Short name:
C21-LRP
Down syndrome critical region protein 2
Gene namesi
Name:PSMG1
Synonyms:C21LRP, DSCR2, PAC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:3043. PSMG1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB
  • Golgi apparatus Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400229.

Polymorphism and mutation databases

BioMutaiPSMG1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 288287Proteasome assembly chaperone 1PRO_0000080018Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei18 – 181PhosphothreonineCombined sources
Modified residuei54 – 541PhosphothreonineCombined sources
Modified residuei180 – 1801PhosphoserineCombined sources
Modified residuei264 – 2641N6-acetyllysineCombined sources

Post-translational modificationi

Degraded by the proteasome upon completion of 20S proteasome maturation.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95456.
MaxQBiO95456.
PaxDbiO95456.
PeptideAtlasiO95456.
PRIDEiO95456.

PTM databases

iPTMnetiO95456.
PhosphoSiteiO95456.

Expressioni

Tissue specificityi

In the adult, detected in brain, colon, leukocytes, breast and testis. Widely expressed in the fetus. Also expressed in a variety of proliferating cell lines.2 Publications

Gene expression databases

BgeeiENSG00000183527.
CleanExiHS_PSMG1.
ExpressionAtlasiO95456. baseline and differential.
GenevisibleiO95456. HS.

Organism-specific databases

HPAiHPA057193.
HPA070225.

Interactioni

Subunit structurei

Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114179. 45 interactions.
IntActiO95456. 7 interactions.
STRINGi9606.ENSP00000329915.

Structurei

3D structure databases

ProteinModelPortaliO95456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PSMG1 family.Curated

Phylogenomic databases

eggNOGiENOG410IGRN. Eukaryota.
ENOG4111EZT. LUCA.
GeneTreeiENSGT00500000044950.
HOGENOMiHOG000072680.
HOVERGENiHBG051410.
InParanoidiO95456.
KOiK11875.
OMAiDYKTSES.
OrthoDBiEOG091G19W8.
PhylomeDBiO95456.
TreeFamiTF331909.

Family and domain databases

InterProiIPR016565. Proteasome_assmbl_chp_1.
[Graphical view]
PfamiPF16094. PAC1. 1 hit.
[Graphical view]
PIRSFiPIRSF010076. Psome_chaperone-1. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95456-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATFFGEVV KAPCRAGTED EEEEEEGRRE TPEDREVRLQ LARKREVRLL
60 70 80 90 100
RRQTKTSLEV SLLEKYPCSK FIIAIGNNAV AFLSSFVMNS GVWEEVGCAK
110 120 130 140 150
LWNEWCRTTD TTHLSSTEAF CVFYHLKSNP SVFLCQCSCY VAEDQQYQWL
160 170 180 190 200
EKVFGSCPRK NMQITILTCR HVTDYKTSES TGSLPSPFLR ALKTQNFKDS
210 220 230 240 250
ACCPLLEQPN IVHDLPAAVL SYCQVWKIPA ILYLCYTDVM KLDLITVEAF
260 270 280
KPILSTRSLK GLVKNIPQST EILKKLMTTN EIQSNIYT
Length:288
Mass (Da):32,854
Last modified:May 1, 1999 - v1
Checksum:i2D4A84485C290839
GO
Isoform 2 (identifier: O95456-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-152: Missing.

Show »
Length:267
Mass (Da):30,288
Checksum:iABC452F240DF79E7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41T → S in CAG46650 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti166 – 1661I → V.
Corresponds to variant rs8131611 [ dbSNP | Ensembl ].
VAR_054014

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei132 – 15221Missing in isoform 2. 2 PublicationsVSP_017261Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006291 mRNA. Translation: CAA06957.1.
AY463963 mRNA. Translation: AAR25628.1.
CR541821 mRNA. Translation: CAG46620.1.
CR541852 mRNA. Translation: CAG46650.1.
AB451468 mRNA. Translation: BAG70282.1.
AL163279 Genomic DNA. Translation: CAB90451.1.
CH471079 Genomic DNA. Translation: EAX09664.1.
CH471079 Genomic DNA. Translation: EAX09665.1.
BC003619 mRNA. Translation: AAH03619.1.
BC010424 mRNA. Translation: AAH10424.1.
BC011755 mRNA. Translation: AAH11755.1.
BC012809 mRNA. Translation: AAH12809.1.
BR000236 mRNA. Translation: FAA00022.1.
CCDSiCCDS13660.1. [O95456-1]
CCDS13661.1. [O95456-2]
PIRiJE0290.
RefSeqiNP_003711.1. NM_003720.3. [O95456-1]
NP_982257.1. NM_203433.2. [O95456-2]
UniGeneiHs.473838.

Genome annotation databases

EnsembliENST00000331573; ENSP00000329915; ENSG00000183527. [O95456-1]
ENST00000380900; ENSP00000370286; ENSG00000183527. [O95456-2]
GeneIDi8624.
KEGGihsa:8624.
UCSCiuc002yxi.5. human. [O95456-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006291 mRNA. Translation: CAA06957.1.
AY463963 mRNA. Translation: AAR25628.1.
CR541821 mRNA. Translation: CAG46620.1.
CR541852 mRNA. Translation: CAG46650.1.
AB451468 mRNA. Translation: BAG70282.1.
AL163279 Genomic DNA. Translation: CAB90451.1.
CH471079 Genomic DNA. Translation: EAX09664.1.
CH471079 Genomic DNA. Translation: EAX09665.1.
BC003619 mRNA. Translation: AAH03619.1.
BC010424 mRNA. Translation: AAH10424.1.
BC011755 mRNA. Translation: AAH11755.1.
BC012809 mRNA. Translation: AAH12809.1.
BR000236 mRNA. Translation: FAA00022.1.
CCDSiCCDS13660.1. [O95456-1]
CCDS13661.1. [O95456-2]
PIRiJE0290.
RefSeqiNP_003711.1. NM_003720.3. [O95456-1]
NP_982257.1. NM_203433.2. [O95456-2]
UniGeneiHs.473838.

3D structure databases

ProteinModelPortaliO95456.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114179. 45 interactions.
IntActiO95456. 7 interactions.
STRINGi9606.ENSP00000329915.

PTM databases

iPTMnetiO95456.
PhosphoSiteiO95456.

Polymorphism and mutation databases

BioMutaiPSMG1.

Proteomic databases

EPDiO95456.
MaxQBiO95456.
PaxDbiO95456.
PeptideAtlasiO95456.
PRIDEiO95456.

Protocols and materials databases

DNASUi8624.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331573; ENSP00000329915; ENSG00000183527. [O95456-1]
ENST00000380900; ENSP00000370286; ENSG00000183527. [O95456-2]
GeneIDi8624.
KEGGihsa:8624.
UCSCiuc002yxi.5. human. [O95456-1]

Organism-specific databases

CTDi8624.
GeneCardsiPSMG1.
HGNCiHGNC:3043. PSMG1.
HPAiHPA057193.
HPA070225.
MIMi605296. gene.
neXtProtiNX_O95456.
PharmGKBiPA162400229.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGRN. Eukaryota.
ENOG4111EZT. LUCA.
GeneTreeiENSGT00500000044950.
HOGENOMiHOG000072680.
HOVERGENiHBG051410.
InParanoidiO95456.
KOiK11875.
OMAiDYKTSES.
OrthoDBiEOG091G19W8.
PhylomeDBiO95456.
TreeFamiTF331909.

Miscellaneous databases

GeneWikiiDSCR2.
GenomeRNAii8624.
PROiO95456.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183527.
CleanExiHS_PSMG1.
ExpressionAtlasiO95456. baseline and differential.
GenevisibleiO95456. HS.

Family and domain databases

InterProiIPR016565. Proteasome_assmbl_chp_1.
[Graphical view]
PfamiPF16094. PAC1. 1 hit.
[Graphical view]
PIRSFiPIRSF010076. Psome_chaperone-1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPSMG1_HUMAN
AccessioniPrimary (citable) accession number: O95456
Secondary accession number(s): B5BUN2
, Q6FHA3, Q6FHD3, Q6S713
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.