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O95455 (TGDS_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
dTDP-D-glucose 4,6-dehydratase

EC=4.2.1.46
Gene names
Name:TGDS
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O.

Cofactor

NAD By similarity.

Sequence similarities

Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnucleotide-sugar metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

dTDP-glucose 4,6-dehydratase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350dTDP-D-glucose 4,6-dehydratase
PRO_0000183250

Sites

Active site1431Proton donor By similarity
Active site1441Proton acceptor By similarity
Active site1661Proton acceptor By similarity
Binding site1421Substrate By similarity

Natural variations

Natural variant151G → S.
Corresponds to variant rs34991132 [ dbSNP | Ensembl ].
VAR_049122

Sequences

Sequence LengthMass (Da)Tools
O95455 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: EE427AD1D91EA43D

FASTA35040,214
        10         20         30         40         50         60 
MSAACWEEPW GLPGGFAKRV LVTGGAGFIA SHMIVSLVED YPNYMIINLD KLDYCASLKN 

        70         80         90        100        110        120 
LETISNKQNY KFIQGDICDS HFVKLLFETE KIDIVLHFAA QTHVDLSFVR AFEFTYVNVY 

       130        140        150        160        170        180 
GTHVLVSAAH EARVEKFIYV STDEVYGGSL DKEFDESSPK QPTNPYASSK AAAECFVQSY 

       190        200        210        220        230        240 
WEQYKFPVVI TRSSNVYGPH QYPEKVIPKF ISLLQHNRKC CIHGSGLQTR NFLYATDVVE 

       250        260        270        280        290        300 
AFLTVLKKGK PGEIYNIGTN FEMSVVQLAK ELIQLIKETN SESEMENWVD YVNDRPTNDM 

       310        320        330        340        350 
RYPMKSEKIH GLGWRPKVPW KEGIKKTIEW YRENFHNWKN VEKALEPFPV 

« Hide

References

« Hide 'large scale' references
[1]"Identification of dTDP-D-glucose 4,6 dehydratase in human cells."
Sturla L., Bisso A., Zanardi D., De Flora A., Tonetti M.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Similar to Haemophilus influenzae dTDP-glucose 4,6-dehydratase."
Seppala R., Lehto V.-P., Gahl W.A.
Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ006068 mRNA. Translation: CAA06840.1.
AF048686 mRNA. Translation: AAD50061.1.
AL139318, AL359708 Genomic DNA. Translation: CAI12084.1.
AL359708, AL139318 Genomic DNA. Translation: CAI12411.1.
BC033675 mRNA. Translation: AAH33675.1.
RefSeqNP_055120.1. NM_014305.2.
UniGeneHs.12393.

3D structure databases

ProteinModelPortalO95455.
SMRO95455. Positions 19-339.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117041. 4 interactions.
IntActO95455. 2 interactions.
STRING9606.ENSP00000261296.

PTM databases

PhosphoSiteO95455.

Proteomic databases

PaxDbO95455.
PRIDEO95455.

Protocols and materials databases

DNASU23483.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261296; ENSP00000261296; ENSG00000088451.
GeneID23483.
KEGGhsa:23483.
UCSCuc001vlw.3. human.

Organism-specific databases

CTD23483.
GeneCardsGC13M095226.
HGNCHGNC:20324. TGDS.
HPAHPA039927.
HPA040857.
neXtProtNX_O95455.
PharmGKBPA128395791.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1088.
HOGENOMHOG000168006.
HOVERGENHBG007741.
InParanoidO95455.
KOK01710.
OMATIDWYRE.
OrthoDBEOG7NKKKR.
PhylomeDBO95455.
TreeFamTF313892.

Gene expression databases

ArrayExpressO95455.
BgeeO95455.
CleanExHS_TGDS.
GenevestigatorO95455.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR005888. dTDP_Gluc_deHydtase.
IPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR10366:SF41. PTHR10366:SF41. 1 hit.
PfamPF01370. Epimerase. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi23483.
NextBio45843.
PROO95455.

Entry information

Entry nameTGDS_HUMAN
AccessionPrimary (citable) accession number: O95455
Secondary accession number(s): Q5T3Z2, Q9H1T9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM