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O95455

- TGDS_HUMAN

UniProt

O95455 - TGDS_HUMAN

Protein

dTDP-D-glucose 4,6-dehydratase

Gene

TGDS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O.

    Cofactori

    NAD.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei142 – 1421SubstrateBy similarity
    Active sitei143 – 1431Proton donorBy similarity
    Active sitei144 – 1441Proton acceptorBy similarity
    Active sitei166 – 1661Proton acceptorBy similarity

    GO - Molecular functioni

    1. coenzyme binding Source: InterPro
    2. dTDP-glucose 4,6-dehydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. nucleotide-sugar metabolic process Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    dTDP-D-glucose 4,6-dehydratase (EC:4.2.1.46)
    Gene namesi
    Name:TGDS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:20324. TGDS.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128395791.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350dTDP-D-glucose 4,6-dehydratasePRO_0000183250Add
    BLAST

    Proteomic databases

    MaxQBiO95455.
    PaxDbiO95455.
    PRIDEiO95455.

    PTM databases

    PhosphoSiteiO95455.

    Expressioni

    Gene expression databases

    ArrayExpressiO95455.
    BgeeiO95455.
    CleanExiHS_TGDS.
    GenevestigatoriO95455.

    Organism-specific databases

    HPAiHPA039927.
    HPA040857.

    Interactioni

    Protein-protein interaction databases

    BioGridi117041. 4 interactions.
    IntActiO95455. 2 interactions.
    STRINGi9606.ENSP00000261296.

    Structurei

    3D structure databases

    ProteinModelPortaliO95455.
    SMRiO95455. Positions 19-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1088.
    HOGENOMiHOG000168006.
    HOVERGENiHBG007741.
    InParanoidiO95455.
    KOiK01710.
    OMAiMSAACWE.
    OrthoDBiEOG7NKKKR.
    PhylomeDBiO95455.
    TreeFamiTF313892.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR005888. dTDP_Gluc_deHydtase.
    IPR001509. Epimerase_deHydtase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR10366:SF41. PTHR10366:SF41. 1 hit.
    PfamiPF01370. Epimerase. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95455-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAACWEEPW GLPGGFAKRV LVTGGAGFIA SHMIVSLVED YPNYMIINLD    50
    KLDYCASLKN LETISNKQNY KFIQGDICDS HFVKLLFETE KIDIVLHFAA 100
    QTHVDLSFVR AFEFTYVNVY GTHVLVSAAH EARVEKFIYV STDEVYGGSL 150
    DKEFDESSPK QPTNPYASSK AAAECFVQSY WEQYKFPVVI TRSSNVYGPH 200
    QYPEKVIPKF ISLLQHNRKC CIHGSGLQTR NFLYATDVVE AFLTVLKKGK 250
    PGEIYNIGTN FEMSVVQLAK ELIQLIKETN SESEMENWVD YVNDRPTNDM 300
    RYPMKSEKIH GLGWRPKVPW KEGIKKTIEW YRENFHNWKN VEKALEPFPV 350
    Length:350
    Mass (Da):40,214
    Last modified:May 1, 1999 - v1
    Checksum:iEE427AD1D91EA43D
    GO

    Sequence cautioni

    The sequence AAH05284.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151G → S.
    Corresponds to variant rs34991132 [ dbSNP | Ensembl ].
    VAR_049122

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006068 mRNA. Translation: CAA06840.1.
    AF048686 mRNA. Translation: AAD50061.1.
    AK313251 mRNA. Translation: BAG36061.1.
    AY544125 mRNA. Translation: AAT11156.1.
    AL139318, AL359708 Genomic DNA. Translation: CAI12084.1.
    AL359708, AL139318 Genomic DNA. Translation: CAI12411.1.
    CH471085 Genomic DNA. Translation: EAX08940.1.
    CH471085 Genomic DNA. Translation: EAX08941.1.
    BC005284 mRNA. Translation: AAH05284.1. Sequence problems.
    BC033675 mRNA. Translation: AAH33675.1.
    CCDSiCCDS9471.1.
    RefSeqiNP_055120.1. NM_014305.2.
    UniGeneiHs.12393.

    Genome annotation databases

    EnsembliENST00000261296; ENSP00000261296; ENSG00000088451.
    GeneIDi23483.
    KEGGihsa:23483.
    UCSCiuc001vlw.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006068 mRNA. Translation: CAA06840.1 .
    AF048686 mRNA. Translation: AAD50061.1 .
    AK313251 mRNA. Translation: BAG36061.1 .
    AY544125 mRNA. Translation: AAT11156.1 .
    AL139318 , AL359708 Genomic DNA. Translation: CAI12084.1 .
    AL359708 , AL139318 Genomic DNA. Translation: CAI12411.1 .
    CH471085 Genomic DNA. Translation: EAX08940.1 .
    CH471085 Genomic DNA. Translation: EAX08941.1 .
    BC005284 mRNA. Translation: AAH05284.1 . Sequence problems.
    BC033675 mRNA. Translation: AAH33675.1 .
    CCDSi CCDS9471.1.
    RefSeqi NP_055120.1. NM_014305.2.
    UniGenei Hs.12393.

    3D structure databases

    ProteinModelPortali O95455.
    SMRi O95455. Positions 19-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117041. 4 interactions.
    IntActi O95455. 2 interactions.
    STRINGi 9606.ENSP00000261296.

    PTM databases

    PhosphoSitei O95455.

    Proteomic databases

    MaxQBi O95455.
    PaxDbi O95455.
    PRIDEi O95455.

    Protocols and materials databases

    DNASUi 23483.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261296 ; ENSP00000261296 ; ENSG00000088451 .
    GeneIDi 23483.
    KEGGi hsa:23483.
    UCSCi uc001vlw.3. human.

    Organism-specific databases

    CTDi 23483.
    GeneCardsi GC13M095226.
    HGNCi HGNC:20324. TGDS.
    HPAi HPA039927.
    HPA040857.
    neXtProti NX_O95455.
    PharmGKBi PA128395791.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1088.
    HOGENOMi HOG000168006.
    HOVERGENi HBG007741.
    InParanoidi O95455.
    KOi K01710.
    OMAi MSAACWE.
    OrthoDBi EOG7NKKKR.
    PhylomeDBi O95455.
    TreeFami TF313892.

    Miscellaneous databases

    GenomeRNAii 23483.
    NextBioi 45843.
    PROi O95455.

    Gene expression databases

    ArrayExpressi O95455.
    Bgeei O95455.
    CleanExi HS_TGDS.
    Genevestigatori O95455.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR005888. dTDP_Gluc_deHydtase.
    IPR001509. Epimerase_deHydtase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10366:SF41. PTHR10366:SF41. 1 hit.
    Pfami PF01370. Epimerase. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of dTDP-D-glucose 4,6 dehydratase in human cells."
      Sturla L., Bisso A., Zanardi D., De Flora A., Tonetti M.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Similar to Haemophilus influenzae dTDP-glucose 4,6-dehydratase."
      Seppala R., Lehto V.-P., Gahl W.A.
      Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pericardium.
    4. "Identification of a human cell growth inhibition gene."
      Kim J.W.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Urinary bladder.

    Entry informationi

    Entry nameiTGDS_HUMAN
    AccessioniPrimary (citable) accession number: O95455
    Secondary accession number(s): Q05DQ3
    , Q2TU31, Q5T3Z2, Q9H1T9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3