O95455 (TGDS_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
dTDP-D-glucose 4,6-dehydratase
EC=4.2.1.46

Gene names

Name:

TGDS

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O.
Cofactor	NAD By similarity.
Sequence similarities	Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nucleotide-sugar metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	coenzyme binding Inferred from electronic annotation. Source: InterPro dTDP-glucose 4,6-dehydratase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	dTDP-D-glucose 4,6-dehydratase		PRO_0000183250
Sites
	Active site	143	1	Proton donor By similarity
	Active site	144	1	Proton acceptor By similarity
	Active site	166	1	Proton acceptor By similarity
	Binding site	142	1	Substrate By similarity
Natural variations
	Natural variant	15	1	G → S. Corresponds to variant rs34991132 [ dbSNP | Ensembl ].		VAR_049122

Sequences

	Sequence		Length	Mass (Da)
	O95455 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: EE427AD1D91EA43D	FASTA	350	40,214
	10 20 30 40 50 60 MSAACWEEPW GLPGGFAKRV LVTGGAGFIA SHMIVSLVED YPNYMIINLD KLDYCASLKN 70 80 90 100 110 120 LETISNKQNY KFIQGDICDS HFVKLLFETE KIDIVLHFAA QTHVDLSFVR AFEFTYVNVY 130 140 150 160 170 180 GTHVLVSAAH EARVEKFIYV STDEVYGGSL DKEFDESSPK QPTNPYASSK AAAECFVQSY 190 200 210 220 230 240 WEQYKFPVVI TRSSNVYGPH QYPEKVIPKF ISLLQHNRKC CIHGSGLQTR NFLYATDVVE 250 260 270 280 290 300 AFLTVLKKGK PGEIYNIGTN FEMSVVQLAK ELIQLIKETN SESEMENWVD YVNDRPTNDM 310 320 330 340 350 RYPMKSEKIH GLGWRPKVPW KEGIKKTIEW YRENFHNWKN VEKALEPFPV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of dTDP-D-glucose 4,6 dehydratase in human cells." Sturla L., Bisso A., Zanardi D., De Flora A., Tonetti M. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Similar to Haemophilus influenzae dTDP-glucose 4,6-dehydratase." Seppala R., Lehto V.-P., Gahl W.A. Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ006068 mRNA. Translation: CAA06840.1. AF048686 mRNA. Translation: AAD50061.1. AL139318, AL359708 Genomic DNA. Translation: CAI12084.1. AL359708, AL139318 Genomic DNA. Translation: CAI12411.1. BC033675 mRNA. Translation: AAH33675.1.
IPI	IPI00003774.
RefSeq	NP_055120.1. NM_014305.2.
UniGene	Hs.12393.
3D structure databases
ProteinModelPortal	O95455.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95455. 2 interactions.
MINT	MINT-4773441.
STRING	9606.ENSP00000261296.
PTM databases
PhosphoSite	O95455.
Proteomic databases
PaxDb	O95455.
PRIDE	O95455.
Protocols and materials databases
DNASU	23483.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000261296; ENSP00000261296; ENSG00000088451.
GeneID	23483.
KEGG	hsa:23483.
UCSC	uc001vlw.3. human.
Organism-specific databases
CTD	23483.
GeneCards	GC13M095226.
HGNC	HGNC:20324. TGDS.
HPA	HPA039927. HPA040857.
neXtProt	NX_O95455.
PharmGKB	PA128395791.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1088.
HOGENOM	HOG000168006.
HOVERGEN	HBG007741.
InParanoid	O95455.
KO	K01710.
OMA	GFIASHM.
OrthoDB	EOG4PVP08.
PhylomeDB	O95455.
Gene expression databases
ArrayExpress	O95455.
Bgee	O95455.
CleanEx	HS_TGDS.
Genevestigator	O95455.
GermOnline	ENSG00000088451. Homo sapiens.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR005888. dTDP_Gluc_deHydtase. IPR001509. Epimerase_deHydtase. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR10366:SF41. PTHR10366:SF41. 1 hit.
Pfam	PF01370. Epimerase. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23483.
NextBio	45843.

Entry information

Entry name

TGDS_HUMAN

Accession

Primary (citable) accession number: O95455
Secondary accession number(s): Q5T3Z2, Q9H1T9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.