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O95455

- TGDS_HUMAN

UniProt

O95455 - TGDS_HUMAN

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Protein
dTDP-D-glucose 4,6-dehydratase
Gene
TGDS
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O.

Cofactori

NAD By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei142 – 1421Substrate By similarity
Active sitei143 – 1431Proton donor By similarity
Active sitei144 – 1441Proton acceptor By similarity
Active sitei166 – 1661Proton acceptor By similarity

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. dTDP-glucose 4,6-dehydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. nucleotide-sugar metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
dTDP-D-glucose 4,6-dehydratase (EC:4.2.1.46)
Gene namesi
Name:TGDS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:20324. TGDS.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128395791.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350dTDP-D-glucose 4,6-dehydratase
PRO_0000183250Add
BLAST

Proteomic databases

MaxQBiO95455.
PaxDbiO95455.
PRIDEiO95455.

PTM databases

PhosphoSiteiO95455.

Expressioni

Gene expression databases

ArrayExpressiO95455.
BgeeiO95455.
CleanExiHS_TGDS.
GenevestigatoriO95455.

Organism-specific databases

HPAiHPA039927.
HPA040857.

Interactioni

Protein-protein interaction databases

BioGridi117041. 4 interactions.
IntActiO95455. 2 interactions.
STRINGi9606.ENSP00000261296.

Structurei

3D structure databases

ProteinModelPortaliO95455.
SMRiO95455. Positions 19-339.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1088.
HOGENOMiHOG000168006.
HOVERGENiHBG007741.
InParanoidiO95455.
KOiK01710.
OMAiMSAACWE.
OrthoDBiEOG7NKKKR.
PhylomeDBiO95455.
TreeFamiTF313892.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005888. dTDP_Gluc_deHydtase.
IPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10366:SF41. PTHR10366:SF41. 1 hit.
PfamiPF01370. Epimerase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95455-1 [UniParc]FASTAAdd to Basket

« Hide

MSAACWEEPW GLPGGFAKRV LVTGGAGFIA SHMIVSLVED YPNYMIINLD    50
KLDYCASLKN LETISNKQNY KFIQGDICDS HFVKLLFETE KIDIVLHFAA 100
QTHVDLSFVR AFEFTYVNVY GTHVLVSAAH EARVEKFIYV STDEVYGGSL 150
DKEFDESSPK QPTNPYASSK AAAECFVQSY WEQYKFPVVI TRSSNVYGPH 200
QYPEKVIPKF ISLLQHNRKC CIHGSGLQTR NFLYATDVVE AFLTVLKKGK 250
PGEIYNIGTN FEMSVVQLAK ELIQLIKETN SESEMENWVD YVNDRPTNDM 300
RYPMKSEKIH GLGWRPKVPW KEGIKKTIEW YRENFHNWKN VEKALEPFPV 350
Length:350
Mass (Da):40,214
Last modified:May 1, 1999 - v1
Checksum:iEE427AD1D91EA43D
GO

Sequence cautioni

The sequence AAH05284.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151G → S.
Corresponds to variant rs34991132 [ dbSNP | Ensembl ].
VAR_049122

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ006068 mRNA. Translation: CAA06840.1.
AF048686 mRNA. Translation: AAD50061.1.
AK313251 mRNA. Translation: BAG36061.1.
AY544125 mRNA. Translation: AAT11156.1.
AL139318, AL359708 Genomic DNA. Translation: CAI12084.1.
AL359708, AL139318 Genomic DNA. Translation: CAI12411.1.
CH471085 Genomic DNA. Translation: EAX08940.1.
CH471085 Genomic DNA. Translation: EAX08941.1.
BC005284 mRNA. Translation: AAH05284.1. Sequence problems.
BC033675 mRNA. Translation: AAH33675.1.
CCDSiCCDS9471.1.
RefSeqiNP_055120.1. NM_014305.2.
UniGeneiHs.12393.

Genome annotation databases

EnsembliENST00000261296; ENSP00000261296; ENSG00000088451.
GeneIDi23483.
KEGGihsa:23483.
UCSCiuc001vlw.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ006068 mRNA. Translation: CAA06840.1 .
AF048686 mRNA. Translation: AAD50061.1 .
AK313251 mRNA. Translation: BAG36061.1 .
AY544125 mRNA. Translation: AAT11156.1 .
AL139318 , AL359708 Genomic DNA. Translation: CAI12084.1 .
AL359708 , AL139318 Genomic DNA. Translation: CAI12411.1 .
CH471085 Genomic DNA. Translation: EAX08940.1 .
CH471085 Genomic DNA. Translation: EAX08941.1 .
BC005284 mRNA. Translation: AAH05284.1 . Sequence problems.
BC033675 mRNA. Translation: AAH33675.1 .
CCDSi CCDS9471.1.
RefSeqi NP_055120.1. NM_014305.2.
UniGenei Hs.12393.

3D structure databases

ProteinModelPortali O95455.
SMRi O95455. Positions 19-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117041. 4 interactions.
IntActi O95455. 2 interactions.
STRINGi 9606.ENSP00000261296.

PTM databases

PhosphoSitei O95455.

Proteomic databases

MaxQBi O95455.
PaxDbi O95455.
PRIDEi O95455.

Protocols and materials databases

DNASUi 23483.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261296 ; ENSP00000261296 ; ENSG00000088451 .
GeneIDi 23483.
KEGGi hsa:23483.
UCSCi uc001vlw.3. human.

Organism-specific databases

CTDi 23483.
GeneCardsi GC13M095226.
HGNCi HGNC:20324. TGDS.
HPAi HPA039927.
HPA040857.
neXtProti NX_O95455.
PharmGKBi PA128395791.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1088.
HOGENOMi HOG000168006.
HOVERGENi HBG007741.
InParanoidi O95455.
KOi K01710.
OMAi MSAACWE.
OrthoDBi EOG7NKKKR.
PhylomeDBi O95455.
TreeFami TF313892.

Miscellaneous databases

GenomeRNAii 23483.
NextBioi 45843.
PROi O95455.

Gene expression databases

ArrayExpressi O95455.
Bgeei O95455.
CleanExi HS_TGDS.
Genevestigatori O95455.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR005888. dTDP_Gluc_deHydtase.
IPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR10366:SF41. PTHR10366:SF41. 1 hit.
Pfami PF01370. Epimerase. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of dTDP-D-glucose 4,6 dehydratase in human cells."
    Sturla L., Bisso A., Zanardi D., De Flora A., Tonetti M.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Similar to Haemophilus influenzae dTDP-glucose 4,6-dehydratase."
    Seppala R., Lehto V.-P., Gahl W.A.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pericardium.
  4. "Identification of a human cell growth inhibition gene."
    Kim J.W.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Urinary bladder.

Entry informationi

Entry nameiTGDS_HUMAN
AccessioniPrimary (citable) accession number: O95455
Secondary accession number(s): Q05DQ3
, Q2TU31, Q5T3Z2, Q9H1T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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