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Protein

Apolipoprotein M

Gene

APOM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136Fatty acid1
Binding sitei143Fatty acid1

GO - Molecular functioni

  • antioxidant activity Source: BHF-UCL
  • lipid transporter activity Source: BHF-UCL
  • phospholipid binding Source: BHF-UCL

GO - Biological processi

  • cholesterol efflux Source: BHF-UCL
  • cholesterol homeostasis Source: BHF-UCL
  • high-density lipoprotein particle assembly Source: BHF-UCL
  • high-density lipoprotein particle clearance Source: BHF-UCL
  • high-density lipoprotein particle remodeling Source: BHF-UCL
  • lipoprotein metabolic process Source: Ensembl
  • negative regulation of plasma lipoprotein particle oxidation Source: BHF-UCL
  • response to glucose Source: Ensembl
  • retinoid metabolic process Source: Reactome
  • reverse cholesterol transport Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111964-MONOMER.
ReactomeiR-HSA-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein M
Short name:
Apo-M
Short name:
ApoM
Alternative name(s):
Protein G3a
Gene namesi
Name:APOM
Synonyms:G3A, NG20
ORF Names:HSPC336
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13916. APOM.

Subcellular locationi

GO - Cellular componenti

  • discoidal high-density lipoprotein particle Source: BHF-UCL
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • high-density lipoprotein particle Source: BHF-UCL
  • integral component of plasma membrane Source: ProtInc
  • low-density lipoprotein particle Source: BHF-UCL
  • spherical high-density lipoprotein particle Source: BHF-UCL
  • very-low-density lipoprotein particle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi22Q → A: Introduces a signal cleavage site. Abolishes interaction with lipoprotein particles. Leads to rapid elimination from plasma. 3 Publications1
Mutagenesisi135N → Q: Loss of glycosylation. 1 Publication1
Mutagenesisi148N → Q: No loss of glycosylation. 1 Publication1

Organism-specific databases

DisGeNETi55937.
OpenTargetsiENSG00000204444.
ENSG00000206409.
ENSG00000224290.
ENSG00000226215.
ENSG00000227567.
ENSG00000231974.
ENSG00000235754.
PharmGKBiPA38370.

Polymorphism and mutation databases

BioMutaiAPOM.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232781 – 188Apolipoprotein MAdd BLAST188
Signal peptidei1 – ?22Not cleavedAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 1671 Publication
Disulfide bondi95 ↔ 1831 Publication
Disulfide bondi128 ↔ 1571 Publication
Glycosylationi135N-linked (GlcNAc...)2 Publications1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO95445.
PaxDbiO95445.
PeptideAtlasiO95445.
PRIDEiO95445.

PTM databases

PhosphoSitePlusiO95445.

Expressioni

Tissue specificityi

Plasma protein. Expressed in liver and kidney.

Gene expression databases

BgeeiENSG00000204444.
CleanExiHS_APOM.
ExpressionAtlasiO95445. baseline and differential.
GenevisibleiO95445. HS.

Organism-specific databases

HPAiCAB034086.
HPA051006.

Interactioni

Protein-protein interaction databases

BioGridi121006. 8 interactors.
IntActiO95445. 2 interactors.
MINTiMINT-1379248.
STRINGi9606.ENSP00000365081.

Structurei

Secondary structure

1188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi36 – 38Combined sources3
Helixi39 – 42Combined sources4
Beta strandi45 – 56Combined sources12
Helixi57 – 63Combined sources7
Beta strandi66 – 75Combined sources10
Beta strandi81 – 90Combined sources10
Beta strandi95 – 104Combined sources10
Beta strandi111 – 113Combined sources3
Beta strandi116 – 124Combined sources9
Beta strandi131 – 138Combined sources8
Beta strandi141 – 152Combined sources12
Helixi155 – 167Combined sources13
Beta strandi172 – 175Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WEWX-ray1.95A22-188[»]
2WEXX-ray2.00A22-188[»]
2YG2X-ray1.70A/B22-188[»]
ProteinModelPortaliO95445.
SMRiO95445.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95445.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IG6S. Eukaryota.
ENOG4111Z0U. LUCA.
GeneTreeiENSGT00390000001026.
HOGENOMiHOG000034009.
HOVERGENiHBG018735.
InParanoidiO95445.
OMAiWYFIAGA.
OrthoDBiEOG091G0L0Y.
PhylomeDBiO95445.
TreeFamiTF330771.

Family and domain databases

InterProiIPR022734. ApoM.
IPR011038. Calycin-like.
[Graphical view]
PfamiPF11032. ApoM. 1 hit.
[Graphical view]
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95445-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFHQIWAALL YFYGIILNSI YQCPEHSQLT TLGVDGKEFP EVHLGQWYFI
60 70 80 90 100
AGAAPTKEEL ATFDPVDNIV FNMAAGSAPM QLHLRATIRM KDGLCVPRKW
110 120 130 140 150
IYHLTEGSTD LRTEGRPDMK TELFSSSCPG GIMLNETGQG YQRFLLYNRS
160 170 180
PHPPEKCVEE FKSLTSCLDS KAFLLTPRNQ EACELSNN
Length:188
Mass (Da):21,253
Last modified:May 1, 2000 - v2
Checksum:iE4C35FEC32B7CB86
GO
Isoform 2 (identifier: O95445-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Note: No experimental confirmation available.
Show »
Length:116
Mass (Da):13,051
Checksum:iF78244DE4A76A382
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 38MFHQI…VDGKE → RFPDSIWGSRSDTSGSPQVP KLYFCGARRESPQPQT in AAF29014 (Ref. 3) CuratedAdd BLAST38
Sequence conflicti175 – 188LTPRN…ELSNN → VDS in CAB51604 (Ref. 2) CuratedAdd BLAST14

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0455861 – 72Missing in isoform 2. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118393 mRNA. Translation: AAD11443.2.
AJ245434 mRNA. Translation: CAB51604.1.
AF161454 mRNA. Translation: AAF29014.1.
AF129756 Genomic DNA. Translation: AAD18084.1.
CN428415 mRNA. No translation available.
BA000025 Genomic DNA. Translation: BAB63389.1.
AL662801 Genomic DNA. Translation: CAI18319.1.
AL670886 Genomic DNA. Translation: CAI17788.1.
AL805934 Genomic DNA. Translation: CAI18511.1.
AL805934 Genomic DNA. Translation: CAI18513.1.
BX511262 Genomic DNA. Translation: CAM45814.1.
BX511262 Genomic DNA. Translation: CAM45816.1.
CR753842 Genomic DNA. Translation: CAQ06561.1.
CR753842 Genomic DNA. Translation: CAQ06563.1.
CR354443 Genomic DNA. Translation: CAQ06991.1.
CR354443 Genomic DNA. Translation: CAQ06993.1.
CR759761 Genomic DNA. Translation: CAQ10868.1.
CR759761 Genomic DNA. Translation: CAQ10870.1.
CH471081 Genomic DNA. Translation: EAX03461.1.
CH471081 Genomic DNA. Translation: EAX03463.1.
BC020683 mRNA. Translation: AAH20683.1.
CCDSiCCDS4710.1. [O95445-1]
CCDS59004.1. [O95445-2]
RefSeqiNP_001243098.1. NM_001256169.1. [O95445-2]
NP_061974.2. NM_019101.2. [O95445-1]
UniGeneiHs.534468.

Genome annotation databases

EnsembliENST00000375916; ENSP00000365081; ENSG00000204444. [O95445-1]
ENST00000375920; ENSP00000365085; ENSG00000204444. [O95445-2]
ENST00000383438; ENSP00000372930; ENSG00000206409. [O95445-1]
ENST00000400157; ENSP00000383021; ENSG00000206409. [O95445-2]
ENST00000416324; ENSP00000393581; ENSG00000224290. [O95445-2]
ENST00000422771; ENSP00000392021; ENSG00000226215. [O95445-2]
ENST00000425177; ENSP00000403062; ENSG00000235754. [O95445-2]
ENST00000426800; ENSP00000405730; ENSG00000227567. [O95445-1]
ENST00000430282; ENSP00000401684; ENSG00000224290. [O95445-1]
ENST00000432598; ENSP00000389591; ENSG00000235754. [O95445-1]
ENST00000436931; ENSP00000394610; ENSG00000231974. [O95445-1]
ENST00000439902; ENSP00000413446; ENSG00000227567. [O95445-2]
ENST00000441436; ENSP00000398944; ENSG00000226215. [O95445-1]
ENST00000443975; ENSP00000416335; ENSG00000231974. [O95445-2]
GeneIDi55937.
KEGGihsa:55937.
UCSCiuc003nvk.5. human. [O95445-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118393 mRNA. Translation: AAD11443.2.
AJ245434 mRNA. Translation: CAB51604.1.
AF161454 mRNA. Translation: AAF29014.1.
AF129756 Genomic DNA. Translation: AAD18084.1.
CN428415 mRNA. No translation available.
BA000025 Genomic DNA. Translation: BAB63389.1.
AL662801 Genomic DNA. Translation: CAI18319.1.
AL670886 Genomic DNA. Translation: CAI17788.1.
AL805934 Genomic DNA. Translation: CAI18511.1.
AL805934 Genomic DNA. Translation: CAI18513.1.
BX511262 Genomic DNA. Translation: CAM45814.1.
BX511262 Genomic DNA. Translation: CAM45816.1.
CR753842 Genomic DNA. Translation: CAQ06561.1.
CR753842 Genomic DNA. Translation: CAQ06563.1.
CR354443 Genomic DNA. Translation: CAQ06991.1.
CR354443 Genomic DNA. Translation: CAQ06993.1.
CR759761 Genomic DNA. Translation: CAQ10868.1.
CR759761 Genomic DNA. Translation: CAQ10870.1.
CH471081 Genomic DNA. Translation: EAX03461.1.
CH471081 Genomic DNA. Translation: EAX03463.1.
BC020683 mRNA. Translation: AAH20683.1.
CCDSiCCDS4710.1. [O95445-1]
CCDS59004.1. [O95445-2]
RefSeqiNP_001243098.1. NM_001256169.1. [O95445-2]
NP_061974.2. NM_019101.2. [O95445-1]
UniGeneiHs.534468.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WEWX-ray1.95A22-188[»]
2WEXX-ray2.00A22-188[»]
2YG2X-ray1.70A/B22-188[»]
ProteinModelPortaliO95445.
SMRiO95445.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121006. 8 interactors.
IntActiO95445. 2 interactors.
MINTiMINT-1379248.
STRINGi9606.ENSP00000365081.

PTM databases

PhosphoSitePlusiO95445.

Polymorphism and mutation databases

BioMutaiAPOM.

Proteomic databases

MaxQBiO95445.
PaxDbiO95445.
PeptideAtlasiO95445.
PRIDEiO95445.

Protocols and materials databases

DNASUi55937.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375916; ENSP00000365081; ENSG00000204444. [O95445-1]
ENST00000375920; ENSP00000365085; ENSG00000204444. [O95445-2]
ENST00000383438; ENSP00000372930; ENSG00000206409. [O95445-1]
ENST00000400157; ENSP00000383021; ENSG00000206409. [O95445-2]
ENST00000416324; ENSP00000393581; ENSG00000224290. [O95445-2]
ENST00000422771; ENSP00000392021; ENSG00000226215. [O95445-2]
ENST00000425177; ENSP00000403062; ENSG00000235754. [O95445-2]
ENST00000426800; ENSP00000405730; ENSG00000227567. [O95445-1]
ENST00000430282; ENSP00000401684; ENSG00000224290. [O95445-1]
ENST00000432598; ENSP00000389591; ENSG00000235754. [O95445-1]
ENST00000436931; ENSP00000394610; ENSG00000231974. [O95445-1]
ENST00000439902; ENSP00000413446; ENSG00000227567. [O95445-2]
ENST00000441436; ENSP00000398944; ENSG00000226215. [O95445-1]
ENST00000443975; ENSP00000416335; ENSG00000231974. [O95445-2]
GeneIDi55937.
KEGGihsa:55937.
UCSCiuc003nvk.5. human. [O95445-1]

Organism-specific databases

CTDi55937.
DisGeNETi55937.
GeneCardsiAPOM.
HGNCiHGNC:13916. APOM.
HPAiCAB034086.
HPA051006.
MIMi606907. gene.
neXtProtiNX_O95445.
OpenTargetsiENSG00000204444.
ENSG00000206409.
ENSG00000224290.
ENSG00000226215.
ENSG00000227567.
ENSG00000231974.
ENSG00000235754.
PharmGKBiPA38370.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG6S. Eukaryota.
ENOG4111Z0U. LUCA.
GeneTreeiENSGT00390000001026.
HOGENOMiHOG000034009.
HOVERGENiHBG018735.
InParanoidiO95445.
OMAiWYFIAGA.
OrthoDBiEOG091G0L0Y.
PhylomeDBiO95445.
TreeFamiTF330771.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111964-MONOMER.
ReactomeiR-HSA-975634. Retinoid metabolism and transport.

Miscellaneous databases

EvolutionaryTraceiO95445.
GeneWikiiAPOM.
GenomeRNAii55937.
PROiO95445.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204444.
CleanExiHS_APOM.
ExpressionAtlasiO95445. baseline and differential.
GenevisibleiO95445. HS.

Family and domain databases

InterProiIPR022734. ApoM.
IPR011038. Calycin-like.
[Graphical view]
PfamiPF11032. ApoM. 1 hit.
[Graphical view]
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAPOM_HUMAN
AccessioniPrimary (citable) accession number: O95445
Secondary accession number(s): B0UX98
, Q5SRP4, Q9P046, Q9UMP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.