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O95445

- APOM_HUMAN

UniProt

O95445 - APOM_HUMAN

Protein

Apolipoprotein M

Gene

APOM

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (01 May 2000)
      Previous versions | rss
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    Functioni

    Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei136 – 1361Fatty acid
    Binding sitei143 – 1431Fatty acid

    GO - Molecular functioni

    1. antioxidant activity Source: BHF-UCL
    2. lipid transporter activity Source: BHF-UCL
    3. phospholipid binding Source: BHF-UCL

    GO - Biological processi

    1. cholesterol efflux Source: BHF-UCL
    2. cholesterol homeostasis Source: BHF-UCL
    3. high-density lipoprotein particle assembly Source: BHF-UCL
    4. high-density lipoprotein particle clearance Source: BHF-UCL
    5. high-density lipoprotein particle remodeling Source: BHF-UCL
    6. lipoprotein metabolic process Source: Ensembl
    7. negative regulation of plasma lipoprotein particle oxidation Source: BHF-UCL
    8. response to glucose Source: Ensembl
    9. reverse cholesterol transport Source: BHF-UCL

    Keywords - Biological processi

    Lipid transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein M
    Short name:
    Apo-M
    Short name:
    ApoM
    Alternative name(s):
    Protein G3a
    Gene namesi
    Name:APOM
    Synonyms:G3A, NG20
    ORF Names:HSPC336
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:13916. APOM.

    Subcellular locationi

    Secreted 3 Publications
    Note: Present in high density lipoprotein (HDL) and to a lesser extent in triglyceride-rich lipoproteins (TGRLP) and low density lipoproteins (LDL).

    GO - Cellular componenti

    1. discoidal high-density lipoprotein particle Source: BHF-UCL
    2. extracellular vesicular exosome Source: UniProt
    3. high-density lipoprotein particle Source: BHF-UCL
    4. integral component of plasma membrane Source: ProtInc
    5. low-density lipoprotein particle Source: BHF-UCL
    6. spherical high-density lipoprotein particle Source: BHF-UCL
    7. very-low-density lipoprotein particle Source: BHF-UCL

    Keywords - Cellular componenti

    HDL, Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi22 – 221Q → A: Introduces a signal cleavage site. Abolishes interaction with lipoprotein particles. Leads to rapid elimination from plasma. 4 Publications
    Mutagenesisi135 – 1351N → Q: Loss of glycosylation. 1 Publication
    Mutagenesisi148 – 1481N → Q: No loss of glycosylation. 1 Publication

    Organism-specific databases

    PharmGKBiPA38370.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 188188Apolipoprotein MPRO_0000223278Add
    BLAST
    Signal peptidei1 – ?2222Not cleavedAdd
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi23 ↔ 1671 Publication
    Disulfide bondi95 ↔ 1831 Publication
    Disulfide bondi128 ↔ 1571 Publication
    Glycosylationi135 – 1351N-linked (GlcNAc...)2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiO95445.
    PaxDbiO95445.
    PeptideAtlasiO95445.
    PRIDEiO95445.

    Expressioni

    Tissue specificityi

    Plasma protein. Expressed in liver and kidney.

    Gene expression databases

    ArrayExpressiO95445.
    BgeeiO95445.
    CleanExiHS_APOM.
    GenevestigatoriO95445.

    Organism-specific databases

    HPAiCAB034086.
    HPA051006.

    Interactioni

    Protein-protein interaction databases

    BioGridi121006. 2 interactions.
    IntActiO95445. 2 interactions.
    MINTiMINT-1379248.
    STRINGi9606.ENSP00000365081.

    Structurei

    Secondary structure

    1
    188
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi36 – 383
    Helixi39 – 424
    Beta strandi45 – 5612
    Helixi57 – 637
    Beta strandi66 – 7510
    Beta strandi81 – 9010
    Beta strandi95 – 10410
    Beta strandi111 – 1133
    Beta strandi116 – 1249
    Beta strandi131 – 1388
    Beta strandi141 – 15212
    Helixi155 – 16713
    Beta strandi172 – 1754

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2WEWX-ray1.95A22-188[»]
    2WEXX-ray2.00A22-188[»]
    2YG2X-ray1.70A/B22-188[»]
    ProteinModelPortaliO95445.
    SMRiO95445. Positions 22-187.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO95445.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40194.
    HOGENOMiHOG000034009.
    HOVERGENiHBG018735.
    InParanoidiO95445.
    OMAiPRNQEAC.
    PhylomeDBiO95445.
    TreeFamiTF330771.

    Family and domain databases

    InterProiIPR022734. ApoM.
    IPR011038. Calycin-like.
    [Graphical view]
    PfamiPF11032. ApoM. 1 hit.
    [Graphical view]
    SUPFAMiSSF50814. SSF50814. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95445-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFHQIWAALL YFYGIILNSI YQCPEHSQLT TLGVDGKEFP EVHLGQWYFI    50
    AGAAPTKEEL ATFDPVDNIV FNMAAGSAPM QLHLRATIRM KDGLCVPRKW 100
    IYHLTEGSTD LRTEGRPDMK TELFSSSCPG GIMLNETGQG YQRFLLYNRS 150
    PHPPEKCVEE FKSLTSCLDS KAFLLTPRNQ EACELSNN 188
    Length:188
    Mass (Da):21,253
    Last modified:May 1, 2000 - v2
    Checksum:iE4C35FEC32B7CB86
    GO
    Isoform 2 (identifier: O95445-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-72: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:116
    Mass (Da):13,051
    Checksum:iF78244DE4A76A382
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 3838MFHQI…VDGKE → RFPDSIWGSRSDTSGSPQVP KLYFCGARRESPQPQT in AAF29014. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti175 – 18814LTPRN…ELSNN → VDS in CAB51604. 1 PublicationCuratedAdd
    BLAST

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7272Missing in isoform 2. 1 PublicationVSP_045586Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF118393 mRNA. Translation: AAD11443.2.
    AJ245434 mRNA. Translation: CAB51604.1.
    AF161454 mRNA. Translation: AAF29014.1.
    AF129756 Genomic DNA. Translation: AAD18084.1.
    CN428415 mRNA. No translation available.
    BA000025 Genomic DNA. Translation: BAB63389.1.
    AL662801 Genomic DNA. Translation: CAI18319.1.
    AL670886 Genomic DNA. Translation: CAI17788.1.
    AL805934 Genomic DNA. Translation: CAI18511.1.
    AL805934 Genomic DNA. Translation: CAI18513.1.
    BX511262 Genomic DNA. Translation: CAM45814.1.
    BX511262 Genomic DNA. Translation: CAM45816.1.
    CR753842 Genomic DNA. Translation: CAQ06561.1.
    CR753842 Genomic DNA. Translation: CAQ06563.1.
    CR354443 Genomic DNA. Translation: CAQ06991.1.
    CR354443 Genomic DNA. Translation: CAQ06993.1.
    CR759761 Genomic DNA. Translation: CAQ10868.1.
    CR759761 Genomic DNA. Translation: CAQ10870.1.
    CH471081 Genomic DNA. Translation: EAX03461.1.
    CH471081 Genomic DNA. Translation: EAX03463.1.
    BC020683 mRNA. Translation: AAH20683.1.
    CCDSiCCDS4710.1. [O95445-1]
    CCDS59004.1. [O95445-2]
    RefSeqiNP_001243098.1. NM_001256169.1. [O95445-2]
    NP_061974.2. NM_019101.2. [O95445-1]
    UniGeneiHs.534468.

    Genome annotation databases

    EnsembliENST00000375916; ENSP00000365081; ENSG00000204444. [O95445-1]
    ENST00000375920; ENSP00000365085; ENSG00000204444. [O95445-2]
    ENST00000383438; ENSP00000372930; ENSG00000206409. [O95445-1]
    ENST00000400157; ENSP00000383021; ENSG00000206409. [O95445-2]
    ENST00000416324; ENSP00000393581; ENSG00000224290. [O95445-2]
    ENST00000422771; ENSP00000392021; ENSG00000226215. [O95445-2]
    ENST00000425177; ENSP00000403062; ENSG00000235754. [O95445-2]
    ENST00000426800; ENSP00000405730; ENSG00000227567. [O95445-1]
    ENST00000430282; ENSP00000401684; ENSG00000224290. [O95445-1]
    ENST00000432598; ENSP00000389591; ENSG00000235754. [O95445-1]
    ENST00000436931; ENSP00000394610; ENSG00000231974. [O95445-1]
    ENST00000439902; ENSP00000413446; ENSG00000227567. [O95445-2]
    ENST00000441436; ENSP00000398944; ENSG00000226215. [O95445-1]
    ENST00000443975; ENSP00000416335; ENSG00000231974. [O95445-2]
    GeneIDi55937.
    KEGGihsa:55937.
    UCSCiuc003nvk.4. human. [O95445-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF118393 mRNA. Translation: AAD11443.2 .
    AJ245434 mRNA. Translation: CAB51604.1 .
    AF161454 mRNA. Translation: AAF29014.1 .
    AF129756 Genomic DNA. Translation: AAD18084.1 .
    CN428415 mRNA. No translation available.
    BA000025 Genomic DNA. Translation: BAB63389.1 .
    AL662801 Genomic DNA. Translation: CAI18319.1 .
    AL670886 Genomic DNA. Translation: CAI17788.1 .
    AL805934 Genomic DNA. Translation: CAI18511.1 .
    AL805934 Genomic DNA. Translation: CAI18513.1 .
    BX511262 Genomic DNA. Translation: CAM45814.1 .
    BX511262 Genomic DNA. Translation: CAM45816.1 .
    CR753842 Genomic DNA. Translation: CAQ06561.1 .
    CR753842 Genomic DNA. Translation: CAQ06563.1 .
    CR354443 Genomic DNA. Translation: CAQ06991.1 .
    CR354443 Genomic DNA. Translation: CAQ06993.1 .
    CR759761 Genomic DNA. Translation: CAQ10868.1 .
    CR759761 Genomic DNA. Translation: CAQ10870.1 .
    CH471081 Genomic DNA. Translation: EAX03461.1 .
    CH471081 Genomic DNA. Translation: EAX03463.1 .
    BC020683 mRNA. Translation: AAH20683.1 .
    CCDSi CCDS4710.1. [O95445-1 ]
    CCDS59004.1. [O95445-2 ]
    RefSeqi NP_001243098.1. NM_001256169.1. [O95445-2 ]
    NP_061974.2. NM_019101.2. [O95445-1 ]
    UniGenei Hs.534468.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2WEW X-ray 1.95 A 22-188 [» ]
    2WEX X-ray 2.00 A 22-188 [» ]
    2YG2 X-ray 1.70 A/B 22-188 [» ]
    ProteinModelPortali O95445.
    SMRi O95445. Positions 22-187.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121006. 2 interactions.
    IntActi O95445. 2 interactions.
    MINTi MINT-1379248.
    STRINGi 9606.ENSP00000365081.

    Proteomic databases

    MaxQBi O95445.
    PaxDbi O95445.
    PeptideAtlasi O95445.
    PRIDEi O95445.

    Protocols and materials databases

    DNASUi 55937.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375916 ; ENSP00000365081 ; ENSG00000204444 . [O95445-1 ]
    ENST00000375920 ; ENSP00000365085 ; ENSG00000204444 . [O95445-2 ]
    ENST00000383438 ; ENSP00000372930 ; ENSG00000206409 . [O95445-1 ]
    ENST00000400157 ; ENSP00000383021 ; ENSG00000206409 . [O95445-2 ]
    ENST00000416324 ; ENSP00000393581 ; ENSG00000224290 . [O95445-2 ]
    ENST00000422771 ; ENSP00000392021 ; ENSG00000226215 . [O95445-2 ]
    ENST00000425177 ; ENSP00000403062 ; ENSG00000235754 . [O95445-2 ]
    ENST00000426800 ; ENSP00000405730 ; ENSG00000227567 . [O95445-1 ]
    ENST00000430282 ; ENSP00000401684 ; ENSG00000224290 . [O95445-1 ]
    ENST00000432598 ; ENSP00000389591 ; ENSG00000235754 . [O95445-1 ]
    ENST00000436931 ; ENSP00000394610 ; ENSG00000231974 . [O95445-1 ]
    ENST00000439902 ; ENSP00000413446 ; ENSG00000227567 . [O95445-2 ]
    ENST00000441436 ; ENSP00000398944 ; ENSG00000226215 . [O95445-1 ]
    ENST00000443975 ; ENSP00000416335 ; ENSG00000231974 . [O95445-2 ]
    GeneIDi 55937.
    KEGGi hsa:55937.
    UCSCi uc003nvk.4. human. [O95445-1 ]

    Organism-specific databases

    CTDi 55937.
    GeneCardsi GC06P031620.
    GC06Pj31607.
    GC06Pk31602.
    GC06Pl31659.
    GC06Pm31696.
    GC06Pn31610.
    GC06Po31610.
    HGNCi HGNC:13916. APOM.
    HPAi CAB034086.
    HPA051006.
    MIMi 606907. gene.
    neXtProti NX_O95445.
    PharmGKBi PA38370.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40194.
    HOGENOMi HOG000034009.
    HOVERGENi HBG018735.
    InParanoidi O95445.
    OMAi PRNQEAC.
    PhylomeDBi O95445.
    TreeFami TF330771.

    Miscellaneous databases

    EvolutionaryTracei O95445.
    GeneWikii APOM.
    GenomeRNAii 55937.
    NextBioi 61349.
    PROi O95445.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95445.
    Bgeei O95445.
    CleanExi HS_APOM.
    Genevestigatori O95445.

    Family and domain databases

    InterProi IPR022734. ApoM.
    IPR011038. Calycin-like.
    [Graphical view ]
    Pfami PF11032. ApoM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50814. SSF50814. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 1-15.
      Tissue: Liver.
    2. "Characterisation of the novel gene G3a located in the class III region of the human major histocompatibility complex."
      Thomson W., Campbell R.D.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Human partial CDS from CD34+ stem cells."
      Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Umbilical cord blood.
    4. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
      Shiina S., Tamiya G., Oka A., Inoko H.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation."
      Brandenberger R., Wei H., Zhang S., Lei S., Murage J., Fisk G.J., Li Y., Xu C., Fang R., Guegler K., Rao M.S., Mandalam R., Lebkowski J., Stanton L.W.
      Nat. Biotechnol. 22:707-716(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Embryonic stem cell.
    7. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Liver.
    10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-135.
      Tissue: Plasma.
    11. "Hydrophobic ligand binding properties of the human lipocalin apolipoprotein M."
      Ahnstrom J., Faber K., Axler O., Dahlback B.
      J. Lipid Res. 48:1754-1762(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLN-22.
    12. "Apolipoprotein M associates to lipoproteins through its retained signal peptide."
      Axler O., Ahnstrom J., Dahlback B.
      FEBS Lett. 582:826-828(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF GLN-22.
    13. "The signal peptide anchors apolipoprotein M in plasma lipoproteins and prevents rapid clearance of apolipoprotein M from plasma."
      Christoffersen C., Ahnstrom J., Axler O., Christensen E.I., Dahlback B., Nielsen L.B.
      J. Biol. Chem. 283:18765-18772(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF GLN-22.
    14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-135.
      Tissue: Liver.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis."
      Duan J., Dahlbaeck B., Villoutreix B.O.
      FEBS Lett. 499:127-132(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING, MUTAGENESIS.
    17. "Serendipitous fatty acid binding reveals the structural determinants for ligand recognition in apolipoprotein M."
      Sevvana M., Ahnstrom J., Egerer-Sieber C., Lange H.A., Dahlback B., Muller Y.A.
      J. Mol. Biol. 393:920-936(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 22-188 IN COMPLEX WITH FATTY ACIDS, DISULFIDE BONDS, FUNCTION.

    Entry informationi

    Entry nameiAPOM_HUMAN
    AccessioniPrimary (citable) accession number: O95445
    Secondary accession number(s): B0UX98
    , Q5SRP4, Q9P046, Q9UMP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3