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O95445

- APOM_HUMAN

UniProt

O95445 - APOM_HUMAN

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Protein

Apolipoprotein M

Gene

APOM

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361Fatty acid
Binding sitei143 – 1431Fatty acid

GO - Molecular functioni

  1. antioxidant activity Source: BHF-UCL
  2. lipid transporter activity Source: BHF-UCL
  3. phospholipid binding Source: BHF-UCL

GO - Biological processi

  1. cholesterol efflux Source: BHF-UCL
  2. cholesterol homeostasis Source: BHF-UCL
  3. high-density lipoprotein particle assembly Source: BHF-UCL
  4. high-density lipoprotein particle clearance Source: BHF-UCL
  5. high-density lipoprotein particle remodeling Source: BHF-UCL
  6. lipoprotein metabolic process Source: Ensembl
  7. negative regulation of plasma lipoprotein particle oxidation Source: BHF-UCL
  8. response to glucose Source: Ensembl
  9. reverse cholesterol transport Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein M
Short name:
Apo-M
Short name:
ApoM
Alternative name(s):
Protein G3a
Gene namesi
Name:APOM
Synonyms:G3A, NG20
ORF Names:HSPC336
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:13916. APOM.

Subcellular locationi

Secreted 3 Publications
Note: Present in high density lipoprotein (HDL) and to a lesser extent in triglyceride-rich lipoproteins (TGRLP) and low density lipoproteins (LDL).

GO - Cellular componenti

  1. discoidal high-density lipoprotein particle Source: BHF-UCL
  2. extracellular vesicular exosome Source: UniProt
  3. high-density lipoprotein particle Source: BHF-UCL
  4. integral component of plasma membrane Source: ProtInc
  5. low-density lipoprotein particle Source: BHF-UCL
  6. spherical high-density lipoprotein particle Source: BHF-UCL
  7. very-low-density lipoprotein particle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi22 – 221Q → A: Introduces a signal cleavage site. Abolishes interaction with lipoprotein particles. Leads to rapid elimination from plasma. 3 Publications
Mutagenesisi135 – 1351N → Q: Loss of glycosylation. 1 Publication
Mutagenesisi148 – 1481N → Q: No loss of glycosylation. 1 Publication

Organism-specific databases

PharmGKBiPA38370.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Apolipoprotein MPRO_0000223278Add
BLAST
Signal peptidei1 – ?2222Not cleavedAdd
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 1671 Publication
Disulfide bondi95 ↔ 1831 Publication
Disulfide bondi128 ↔ 1571 Publication
Glycosylationi135 – 1351N-linked (GlcNAc...)2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO95445.
PaxDbiO95445.
PeptideAtlasiO95445.
PRIDEiO95445.

Expressioni

Tissue specificityi

Plasma protein. Expressed in liver and kidney.

Gene expression databases

BgeeiO95445.
CleanExiHS_APOM.
ExpressionAtlasiO95445. baseline and differential.
GenevestigatoriO95445.

Organism-specific databases

HPAiCAB034086.
HPA051006.

Interactioni

Protein-protein interaction databases

BioGridi121006. 2 interactions.
IntActiO95445. 2 interactions.
MINTiMINT-1379248.
STRINGi9606.ENSP00000365081.

Structurei

Secondary structure

1
188
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi36 – 383Combined sources
Helixi39 – 424Combined sources
Beta strandi45 – 5612Combined sources
Helixi57 – 637Combined sources
Beta strandi66 – 7510Combined sources
Beta strandi81 – 9010Combined sources
Beta strandi95 – 10410Combined sources
Beta strandi111 – 1133Combined sources
Beta strandi116 – 1249Combined sources
Beta strandi131 – 1388Combined sources
Beta strandi141 – 15212Combined sources
Helixi155 – 16713Combined sources
Beta strandi172 – 1754Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WEWX-ray1.95A22-188[»]
2WEXX-ray2.00A22-188[»]
2YG2X-ray1.70A/B22-188[»]
ProteinModelPortaliO95445.
SMRiO95445. Positions 22-187.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95445.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40194.
GeneTreeiENSGT00390000001026.
HOGENOMiHOG000034009.
HOVERGENiHBG018735.
InParanoidiO95445.
OMAiPRNQEAC.
PhylomeDBiO95445.
TreeFamiTF330771.

Family and domain databases

InterProiIPR022734. ApoM.
IPR011038. Calycin-like.
[Graphical view]
PfamiPF11032. ApoM. 1 hit.
[Graphical view]
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95445-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFHQIWAALL YFYGIILNSI YQCPEHSQLT TLGVDGKEFP EVHLGQWYFI
60 70 80 90 100
AGAAPTKEEL ATFDPVDNIV FNMAAGSAPM QLHLRATIRM KDGLCVPRKW
110 120 130 140 150
IYHLTEGSTD LRTEGRPDMK TELFSSSCPG GIMLNETGQG YQRFLLYNRS
160 170 180
PHPPEKCVEE FKSLTSCLDS KAFLLTPRNQ EACELSNN
Length:188
Mass (Da):21,253
Last modified:May 1, 2000 - v2
Checksum:iE4C35FEC32B7CB86
GO
Isoform 2 (identifier: O95445-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Note: No experimental confirmation available.

Show »
Length:116
Mass (Da):13,051
Checksum:iF78244DE4A76A382
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 3838MFHQI…VDGKE → RFPDSIWGSRSDTSGSPQVP KLYFCGARRESPQPQT in AAF29014. 1 PublicationCuratedAdd
BLAST
Sequence conflicti175 – 18814LTPRN…ELSNN → VDS in CAB51604. 1 PublicationCuratedAdd
BLAST

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7272Missing in isoform 2. 1 PublicationVSP_045586Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118393 mRNA. Translation: AAD11443.2.
AJ245434 mRNA. Translation: CAB51604.1.
AF161454 mRNA. Translation: AAF29014.1.
AF129756 Genomic DNA. Translation: AAD18084.1.
CN428415 mRNA. No translation available.
BA000025 Genomic DNA. Translation: BAB63389.1.
AL662801 Genomic DNA. Translation: CAI18319.1.
AL670886 Genomic DNA. Translation: CAI17788.1.
AL805934 Genomic DNA. Translation: CAI18511.1.
AL805934 Genomic DNA. Translation: CAI18513.1.
BX511262 Genomic DNA. Translation: CAM45814.1.
BX511262 Genomic DNA. Translation: CAM45816.1.
CR753842 Genomic DNA. Translation: CAQ06561.1.
CR753842 Genomic DNA. Translation: CAQ06563.1.
CR354443 Genomic DNA. Translation: CAQ06991.1.
CR354443 Genomic DNA. Translation: CAQ06993.1.
CR759761 Genomic DNA. Translation: CAQ10868.1.
CR759761 Genomic DNA. Translation: CAQ10870.1.
CH471081 Genomic DNA. Translation: EAX03461.1.
CH471081 Genomic DNA. Translation: EAX03463.1.
BC020683 mRNA. Translation: AAH20683.1.
CCDSiCCDS4710.1. [O95445-1]
CCDS59004.1. [O95445-2]
RefSeqiNP_001243098.1. NM_001256169.1. [O95445-2]
NP_061974.2. NM_019101.2. [O95445-1]
UniGeneiHs.534468.

Genome annotation databases

EnsembliENST00000375916; ENSP00000365081; ENSG00000204444. [O95445-1]
ENST00000375920; ENSP00000365085; ENSG00000204444. [O95445-2]
ENST00000383438; ENSP00000372930; ENSG00000206409. [O95445-1]
ENST00000400157; ENSP00000383021; ENSG00000206409. [O95445-2]
ENST00000416324; ENSP00000393581; ENSG00000224290. [O95445-2]
ENST00000422771; ENSP00000392021; ENSG00000226215. [O95445-2]
ENST00000425177; ENSP00000403062; ENSG00000235754. [O95445-2]
ENST00000426800; ENSP00000405730; ENSG00000227567. [O95445-1]
ENST00000430282; ENSP00000401684; ENSG00000224290. [O95445-1]
ENST00000432598; ENSP00000389591; ENSG00000235754. [O95445-1]
ENST00000436931; ENSP00000394610; ENSG00000231974. [O95445-1]
ENST00000439902; ENSP00000413446; ENSG00000227567. [O95445-2]
ENST00000441436; ENSP00000398944; ENSG00000226215. [O95445-1]
ENST00000443975; ENSP00000416335; ENSG00000231974. [O95445-2]
GeneIDi55937.
KEGGihsa:55937.
UCSCiuc003nvk.4. human. [O95445-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118393 mRNA. Translation: AAD11443.2 .
AJ245434 mRNA. Translation: CAB51604.1 .
AF161454 mRNA. Translation: AAF29014.1 .
AF129756 Genomic DNA. Translation: AAD18084.1 .
CN428415 mRNA. No translation available.
BA000025 Genomic DNA. Translation: BAB63389.1 .
AL662801 Genomic DNA. Translation: CAI18319.1 .
AL670886 Genomic DNA. Translation: CAI17788.1 .
AL805934 Genomic DNA. Translation: CAI18511.1 .
AL805934 Genomic DNA. Translation: CAI18513.1 .
BX511262 Genomic DNA. Translation: CAM45814.1 .
BX511262 Genomic DNA. Translation: CAM45816.1 .
CR753842 Genomic DNA. Translation: CAQ06561.1 .
CR753842 Genomic DNA. Translation: CAQ06563.1 .
CR354443 Genomic DNA. Translation: CAQ06991.1 .
CR354443 Genomic DNA. Translation: CAQ06993.1 .
CR759761 Genomic DNA. Translation: CAQ10868.1 .
CR759761 Genomic DNA. Translation: CAQ10870.1 .
CH471081 Genomic DNA. Translation: EAX03461.1 .
CH471081 Genomic DNA. Translation: EAX03463.1 .
BC020683 mRNA. Translation: AAH20683.1 .
CCDSi CCDS4710.1. [O95445-1 ]
CCDS59004.1. [O95445-2 ]
RefSeqi NP_001243098.1. NM_001256169.1. [O95445-2 ]
NP_061974.2. NM_019101.2. [O95445-1 ]
UniGenei Hs.534468.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2WEW X-ray 1.95 A 22-188 [» ]
2WEX X-ray 2.00 A 22-188 [» ]
2YG2 X-ray 1.70 A/B 22-188 [» ]
ProteinModelPortali O95445.
SMRi O95445. Positions 22-187.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121006. 2 interactions.
IntActi O95445. 2 interactions.
MINTi MINT-1379248.
STRINGi 9606.ENSP00000365081.

Proteomic databases

MaxQBi O95445.
PaxDbi O95445.
PeptideAtlasi O95445.
PRIDEi O95445.

Protocols and materials databases

DNASUi 55937.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375916 ; ENSP00000365081 ; ENSG00000204444 . [O95445-1 ]
ENST00000375920 ; ENSP00000365085 ; ENSG00000204444 . [O95445-2 ]
ENST00000383438 ; ENSP00000372930 ; ENSG00000206409 . [O95445-1 ]
ENST00000400157 ; ENSP00000383021 ; ENSG00000206409 . [O95445-2 ]
ENST00000416324 ; ENSP00000393581 ; ENSG00000224290 . [O95445-2 ]
ENST00000422771 ; ENSP00000392021 ; ENSG00000226215 . [O95445-2 ]
ENST00000425177 ; ENSP00000403062 ; ENSG00000235754 . [O95445-2 ]
ENST00000426800 ; ENSP00000405730 ; ENSG00000227567 . [O95445-1 ]
ENST00000430282 ; ENSP00000401684 ; ENSG00000224290 . [O95445-1 ]
ENST00000432598 ; ENSP00000389591 ; ENSG00000235754 . [O95445-1 ]
ENST00000436931 ; ENSP00000394610 ; ENSG00000231974 . [O95445-1 ]
ENST00000439902 ; ENSP00000413446 ; ENSG00000227567 . [O95445-2 ]
ENST00000441436 ; ENSP00000398944 ; ENSG00000226215 . [O95445-1 ]
ENST00000443975 ; ENSP00000416335 ; ENSG00000231974 . [O95445-2 ]
GeneIDi 55937.
KEGGi hsa:55937.
UCSCi uc003nvk.4. human. [O95445-1 ]

Organism-specific databases

CTDi 55937.
GeneCardsi GC06P031620.
GC06Pj31607.
GC06Pk31602.
GC06Pl31659.
GC06Pm31696.
GC06Pn31610.
GC06Po31610.
HGNCi HGNC:13916. APOM.
HPAi CAB034086.
HPA051006.
MIMi 606907. gene.
neXtProti NX_O95445.
PharmGKBi PA38370.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40194.
GeneTreei ENSGT00390000001026.
HOGENOMi HOG000034009.
HOVERGENi HBG018735.
InParanoidi O95445.
OMAi PRNQEAC.
PhylomeDBi O95445.
TreeFami TF330771.

Miscellaneous databases

EvolutionaryTracei O95445.
GeneWikii APOM.
GenomeRNAii 55937.
NextBioi 61349.
PROi O95445.
SOURCEi Search...

Gene expression databases

Bgeei O95445.
CleanExi HS_APOM.
ExpressionAtlasi O95445. baseline and differential.
Genevestigatori O95445.

Family and domain databases

InterProi IPR022734. ApoM.
IPR011038. Calycin-like.
[Graphical view ]
Pfami PF11032. ApoM. 1 hit.
[Graphical view ]
SUPFAMi SSF50814. SSF50814. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 1-15.
    Tissue: Liver.
  2. "Characterisation of the novel gene G3a located in the class III region of the human major histocompatibility complex."
    Thomson W., Campbell R.D.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Human partial CDS from CD34+ stem cells."
    Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  4. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation."
    Brandenberger R., Wei H., Zhang S., Lei S., Murage J., Fisk G.J., Li Y., Xu C., Fang R., Guegler K., Rao M.S., Mandalam R., Lebkowski J., Stanton L.W.
    Nat. Biotechnol. 22:707-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryonic stem cell.
  7. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.
  10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-135.
    Tissue: Plasma.
  11. "Hydrophobic ligand binding properties of the human lipocalin apolipoprotein M."
    Ahnstrom J., Faber K., Axler O., Dahlback B.
    J. Lipid Res. 48:1754-1762(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLN-22.
  12. "Apolipoprotein M associates to lipoproteins through its retained signal peptide."
    Axler O., Ahnstrom J., Dahlback B.
    FEBS Lett. 582:826-828(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF GLN-22.
  13. "The signal peptide anchors apolipoprotein M in plasma lipoproteins and prevents rapid clearance of apolipoprotein M from plasma."
    Christoffersen C., Ahnstrom J., Axler O., Christensen E.I., Dahlback B., Nielsen L.B.
    J. Biol. Chem. 283:18765-18772(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF GLN-22.
  14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-135.
    Tissue: Liver.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis."
    Duan J., Dahlbaeck B., Villoutreix B.O.
    FEBS Lett. 499:127-132(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING, MUTAGENESIS.
  17. "Serendipitous fatty acid binding reveals the structural determinants for ligand recognition in apolipoprotein M."
    Sevvana M., Ahnstrom J., Egerer-Sieber C., Lange H.A., Dahlback B., Muller Y.A.
    J. Mol. Biol. 393:920-936(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 22-188 IN COMPLEX WITH FATTY ACIDS, DISULFIDE BONDS, FUNCTION.

Entry informationi

Entry nameiAPOM_HUMAN
AccessioniPrimary (citable) accession number: O95445
Secondary accession number(s): B0UX98
, Q5SRP4, Q9P046, Q9UMP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

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