ID NPT2B_HUMAN Reviewed; 690 AA. AC O95436; A5PL17; Q8N2K2; Q8WYA9; Q9P0V7; DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot. DT 30-NOV-2010, sequence version 3. DT 24-JAN-2024, entry version 168. DE RecName: Full=Sodium-dependent phosphate transport protein 2B; DE Short=Sodium-phosphate transport protein 2B; DE AltName: Full=Na(+)-dependent phosphate cotransporter 2B; DE AltName: Full=NaPi3b; DE AltName: Full=Sodium/phosphate cotransporter 2B; DE Short=Na(+)/Pi cotransporter 2B; DE Short=NaPi-2b; DE AltName: Full=Solute carrier family 34 member 2; GN Name=SLC34A2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), BIOPHYSICOCHEMICAL PROPERTIES RP (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION (ISOFORM 1), TRANSPORTER ACTIVITY RP (ISOFORM 1), AND VARIANT GLY-634. RC TISSUE=Lung, and Small intestine; RX PubMed=10329428; DOI=10.1006/bbrc.1999.0666; RA Feild J.A., Zhang L., Brun K.A., Brooks D.P., Edwards R.M.; RT "Cloning and functional characterization of a sodium-dependent phosphate RT transporter expressed in human lung and small intestine."; RL Biochem. Biophys. Res. Commun. 258:578-582(1999). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION (ISOFORM 2), TRANSPORTER RP ACTIVITY (ISOFORM 2), TISSUE SPECIFICITY, AND VARIANT GLY-634. RC TISSUE=Small intestine; RX PubMed=10610722; DOI=10.1006/geno.1999.6009; RA Xu H., Bai L., Collins J.F., Ghishan F.K.; RT "Molecular cloning, functional characterization, tissue distribution, and RT chromosomal localization of a human, small intestinal sodium-phosphate RT (Na+-Pi) transporter (SLC34A2)."; RL Genomics 62:281-284(1999). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT GLY-634. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-592 (ISOFORM 2), AND INDUCTION. RC TISSUE=Intestine; RX PubMed=11171583; DOI=10.1152/ajpcell.2001.280.3.c628; RA Xu H., Collins J.F., Bai L., Kiela P.R., Ghishan F.K.; RT "Regulation of the human sodium-phosphate cotransporter NaPi-IIb gene RT promoter by epidermal growth factor."; RL Am. J. Physiol. 280:C628-C636(2001). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 266-690, AND VARIANT GLY-634. RC TISSUE=Ovarian carcinoma; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [7] RP DISEASE, AND CHROMOSOMAL TRANSLOCATION WITH ROS1. RX PubMed=12661006; DOI=10.1002/gcc.10207; RA Charest A., Lane K., McMahon K., Park J., Preisinger E., Conroy H., RA Housman D.; RT "Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with RT an interstitial del(6)(q21q21)."; RL Genes Chromosomes Cancer 37:58-71(2003). RN [8] RP VARIANT PULAM ARG-106. RX PubMed=16960801; DOI=10.1086/508263; RA Corut A., Senyigit A., Ugur S.A., Altin S., Ozcelik U., Calisir H., RA Yildirim Z., Gocmen A., Tolun A.; RT "Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are RT possibly associated with testicular microlithiasis."; RL Am. J. Hum. Genet. 79:650-656(2006). CC -!- FUNCTION: Involved in actively transporting phosphate into cells via CC Na(+) cotransport. {ECO:0000269|PubMed:10329428}. CC -!- CATALYTIC ACTIVITY: [Isoform 1]: CC Reaction=3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in); CC Xref=Rhea:RHEA:71255, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474; CC Evidence={ECO:0000269|PubMed:10329428}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71256; CC Evidence={ECO:0000305|PubMed:10329428}; CC -!- CATALYTIC ACTIVITY: [Isoform 2]: CC Reaction=3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in); CC Xref=Rhea:RHEA:71255, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474; CC Evidence={ECO:0000269|PubMed:10610722}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71256; CC Evidence={ECO:0000305|PubMed:10610722}; CC -!- BIOPHYSICOCHEMICAL PROPERTIES: [Isoform 1]: CC pH dependence: CC Optimum pH is 6.6. {ECO:0000269|PubMed:10329428}; CC -!- INTERACTION: CC O95436-2; Q9NVV5-2: AIG1; NbExp=3; IntAct=EBI-12811757, EBI-11957045; CC O95436-2; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-12811757, EBI-711490; CC O95436-2; Q02747: GUCA2A; NbExp=3; IntAct=EBI-12811757, EBI-12244272; CC O95436-2; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-12811757, EBI-10266796; CC O95436-2; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-12811757, EBI-2820517; CC O95436-2; P26678: PLN; NbExp=3; IntAct=EBI-12811757, EBI-692836; CC O95436-2; P54315: PNLIPRP1; NbExp=3; IntAct=EBI-12811757, EBI-8652812; CC O95436-2; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-12811757, EBI-10244780; CC O95436-2; Q99726: SLC30A3; NbExp=5; IntAct=EBI-12811757, EBI-10294651; CC O95436-2; P78382: SLC35A1; NbExp=3; IntAct=EBI-12811757, EBI-12870360; CC O95436-2; Q92504: SLC39A7; NbExp=3; IntAct=EBI-12811757, EBI-1051105; CC O95436-2; P0DN84: STRIT1; NbExp=3; IntAct=EBI-12811757, EBI-12200293; CC O95436-2; Q9Y6I9: TEX264; NbExp=3; IntAct=EBI-12811757, EBI-10329860; CC O95436-2; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-12811757, EBI-10694905; CC O95436-2; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-12811757, EBI-11528917; CC O95436-2; Q69YG0: TMEM42; NbExp=3; IntAct=EBI-12811757, EBI-12038591; CC O95436-2; Q5TGU0: TSPO2; NbExp=3; IntAct=EBI-12811757, EBI-12195249; CC O95436-2; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-12811757, EBI-11988865; CC -!- SUBCELLULAR LOCATION: Apical cell membrane CC {ECO:0000250|UniProtKB:Q9DBP0}; Multi-pass membrane protein CC {ECO:0000255}. Note=Localized at the brush border membranes of CC enterocytes. {ECO:0000250|UniProtKB:Q9DBP0}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; Synonyms=NaPi-3b; CC IsoId=O95436-1; Sequence=Displayed; CC Name=2; Synonyms=NaPi-2b, NaPi-IIb; CC IsoId=O95436-2; Sequence=VSP_016755; CC -!- TISSUE SPECIFICITY: Highly expressed in lung. Also detected in CC pancreas, kidney, small intestine, ovary, testis, prostate and mammary CC gland. In lung, it is found in alveolar type II cells but not in CC bronchiolar epithelium. {ECO:0000269|PubMed:10329428, CC ECO:0000269|PubMed:10610722}. CC -!- INDUCTION: Down-regulated by EGF. {ECO:0000269|PubMed:11171583}. CC -!- DISEASE: Pulmonary alveolar microlithiasis (PULAM) [MIM:265100]: Rare CC disease characterized by the deposition of calcium phosphate microliths CC throughout the lungs. Most patients are asymptomatic for several years CC or even for decades and generally, the diagnosis is incidental to CC clinical investigations unrelated to the disease. Cases with early- CC onset or rapid progression are rare. A 'sandstorm-appearing' chest CC roentgenogram is a typical diagnostic finding. The onset of this CC potentially lethal disease varies from the neonatal period to old age CC and the disease follows a long-term, progressive course, resulting in a CC slow deterioration of lung functions. Pulmonary alveolar microlithiasis CC is a recessive monogenic disease with full penetrance. CC {ECO:0000269|PubMed:16960801}. Note=The disease is caused by variants CC affecting the gene represented in this entry. CC -!- DISEASE: Note=A chromosomal aberration involving SLC34A2 is found in a CC glioblastoma multiforme cell line U-118MG. Results in the formation of CC a SLC34A2-ROS1 chimeric protein that retains a constitutive kinase CC activity. {ECO:0000269|PubMed:12661006}. CC -!- SIMILARITY: Belongs to the SLC34A transporter family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAC11354.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF111856; AAC98695.1; -; mRNA. DR EMBL; AF146796; AAF31328.1; -; mRNA. DR EMBL; AC092436; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC142704; AAI42705.1; -; mRNA. DR EMBL; BC146666; AAI46667.1; -; mRNA. DR EMBL; AH011306; AAL55657.1; -; Genomic_DNA. DR EMBL; AK075015; BAC11354.1; ALT_INIT; mRNA. DR CCDS; CCDS3435.1; -. [O95436-1] DR CCDS; CCDS54750.1; -. [O95436-2] DR RefSeq; NP_001171469.1; NM_001177998.1. [O95436-2] DR RefSeq; NP_001171470.1; NM_001177999.1. [O95436-2] DR RefSeq; NP_006415.2; NM_006424.2. [O95436-1] DR AlphaFoldDB; O95436; -. DR BioGRID; 115819; 50. DR IntAct; O95436; 32. DR STRING; 9606.ENSP00000371483; -. DR ChEMBL; CHEMBL4295685; -. DR DrugBank; DB11348; Calcium Phosphate. DR DrugBank; DB14481; Calcium phosphate dihydrate. DR DrugBank; DB14502; Sodium phosphate, dibasic. DR DrugBank; DB09449; Sodium phosphate, monobasic. DR DrugBank; DB14503; Sodium phosphate, monobasic, unspecified form. DR GuidetoPHARMACOLOGY; 1136; -. DR TCDB; 2.A.58.1.4; the phosphate:na(+) symporter (pnas) family. DR GlyCosmos; O95436; 5 sites, No reported glycans. DR GlyGen; O95436; 6 sites, 1 O-linked glycan (1 site). DR iPTMnet; O95436; -. DR PhosphoSitePlus; O95436; -. DR BioMuta; SLC34A2; -. DR MassIVE; O95436; -. DR MaxQB; O95436; -. DR PaxDb; 9606-ENSP00000371483; -. DR PeptideAtlas; O95436; -. DR ProteomicsDB; 50879; -. [O95436-1] DR ProteomicsDB; 50880; -. [O95436-2] DR ABCD; O95436; 1 sequenced antibody. DR Antibodypedia; 51936; 222 antibodies from 25 providers. DR DNASU; 10568; -. DR Ensembl; ENST00000382051.8; ENSP00000371483.3; ENSG00000157765.13. [O95436-1] DR Ensembl; ENST00000503434.5; ENSP00000423021.1; ENSG00000157765.13. [O95436-2] DR Ensembl; ENST00000504570.5; ENSP00000425501.1; ENSG00000157765.13. [O95436-2] DR Ensembl; ENST00000645788.1; ENSP00000494094.1; ENSG00000157765.13. [O95436-2] DR GeneID; 10568; -. DR KEGG; hsa:10568; -. DR MANE-Select; ENST00000382051.8; ENSP00000371483.3; NM_006424.3; NP_006415.3. DR UCSC; uc003grr.4; human. [O95436-1] DR AGR; HGNC:11020; -. DR CTD; 10568; -. DR DisGeNET; 10568; -. DR GeneCards; SLC34A2; -. DR HGNC; HGNC:11020; SLC34A2. DR HPA; ENSG00000157765; Tissue enriched (lung). DR MalaCards; SLC34A2; -. DR MIM; 265100; phenotype. DR MIM; 604217; gene. DR neXtProt; NX_O95436; -. DR OpenTargets; ENSG00000157765; -. DR Orphanet; 60025; Pulmonary alveolar microlithiasis. DR PharmGKB; PA35888; -. DR VEuPathDB; HostDB:ENSG00000157765; -. DR eggNOG; ENOG502QQ3I; Eukaryota. DR GeneTree; ENSGT00950000183177; -. DR HOGENOM; CLU_025063_0_0_1; -. DR InParanoid; O95436; -. DR OMA; GCPKCCR; -. DR OrthoDB; 5404387at2759; -. DR PhylomeDB; O95436; -. DR TreeFam; TF313981; -. DR BioCyc; MetaCyc:ENSG00000157765-MONOMER; -. DR PathwayCommons; O95436; -. DR Reactome; R-HSA-427589; Type II Na+/Pi cotransporters. DR Reactome; R-HSA-5619045; Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM). DR Reactome; R-HSA-5683826; Surfactant metabolism. DR Reactome; R-HSA-5687583; Defective SLC34A2 causes PALM. DR SignaLink; O95436; -. DR SIGNOR; O95436; -. DR BioGRID-ORCS; 10568; 15 hits in 1154 CRISPR screens. DR ChiTaRS; SLC34A2; human. DR GeneWiki; SLC34A2; -. DR GenomeRNAi; 10568; -. DR Pharos; O95436; Tchem. DR PRO; PR:O95436; -. DR Proteomes; UP000005640; Chromosome 4. DR RNAct; O95436; Protein. DR Bgee; ENSG00000157765; Expressed in lower lobe of lung and 111 other cell types or tissues. DR ExpressionAtlas; O95436; baseline and differential. DR GO; GO:0016324; C:apical plasma membrane; IDA:UniProtKB. DR GO; GO:0005903; C:brush border; IBA:GO_Central. DR GO; GO:0031526; C:brush border membrane; ISS:UniProtKB. DR GO; GO:0016020; C:membrane; IDA:UniProtKB. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0031982; C:vesicle; HDA:UniProtKB. DR GO; GO:0042301; F:phosphate ion binding; IDA:UniProtKB. DR GO; GO:0031402; F:sodium ion binding; IDA:UniProtKB. DR GO; GO:0005436; F:sodium:phosphate symporter activity; IDA:UniProtKB. DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl. DR GO; GO:0030643; P:intracellular phosphate ion homeostasis; IDA:UniProtKB. DR GO; GO:0006817; P:phosphate ion transport; IDA:UniProtKB. DR GO; GO:0019538; P:protein metabolic process; TAS:Reactome. DR GO; GO:0043627; P:response to estrogen; IEP:UniProtKB. DR GO; GO:0044341; P:sodium-dependent phosphate transport; IBA:GO_Central. DR InterPro; IPR003841; Na/Pi_transpt. DR NCBIfam; TIGR01013; 2a58; 1. DR NCBIfam; NF037997; Na_Pi_symport; 1. DR PANTHER; PTHR10010:SF23; SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2B; 1. DR PANTHER; PTHR10010; SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED; 1. DR Pfam; PF02690; Na_Pi_cotrans; 2. DR Genevisible; O95436; HS. PE 1: Evidence at protein level; KW Alternative splicing; Cell membrane; Disease variant; Disulfide bond; KW Glycoprotein; Ion transport; Membrane; Reference proteome; Sodium; KW Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. FT CHAIN 1..690 FT /note="Sodium-dependent phosphate transport protein 2B" FT /id="PRO_0000068613" FT TOPO_DOM 1..100 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 101..121 FT /note="Helical; Name=M1" FT /evidence="ECO:0000255" FT TOPO_DOM 122..135 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 136..156 FT /note="Helical; Name=M2" FT /evidence="ECO:0000255" FT TOPO_DOM 157..212 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 213..233 FT /note="Helical; Name=M3" FT /evidence="ECO:0000255" FT TOPO_DOM 234..362 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 363..383 FT /note="Helical; Name=M4" FT /evidence="ECO:0000255" FT TOPO_DOM 384..407 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 408..428 FT /note="Helical; Name=M5" FT /evidence="ECO:0000255" FT TOPO_DOM 429..485 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 486..506 FT /note="Helical; Name=M6" FT /evidence="ECO:0000255" FT TOPO_DOM 507..525 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 526..546 FT /note="Helical; Name=M7" FT /evidence="ECO:0000255" FT TOPO_DOM 547..552 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 553..573 FT /note="Helical; Name=M8" FT /evidence="ECO:0000255" FT TOPO_DOM 574..689 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT REGION 1..42 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT SITE 126..127 FT /note="Breakpoint for translocation to form a SLC34A2-ROS1 FT fusion protein" FT CARBOHYD 295 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 308 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 313 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 321 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 340 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 303..350 FT /evidence="ECO:0000250|UniProtKB:Q06496" FT VAR_SEQ 38..39 FT /note="TD -> N (in isoform 2)" FT /evidence="ECO:0000303|PubMed:10610722, FT ECO:0000303|PubMed:15489334" FT /id="VSP_016755" FT VARIANT 45 FT /note="V -> A (in dbSNP:rs35426730)" FT /id="VAR_034156" FT VARIANT 106 FT /note="G -> R (in PULAM; dbSNP:rs137853142)" FT /evidence="ECO:0000269|PubMed:16960801" FT /id="VAR_030677" FT VARIANT 634 FT /note="D -> G (in dbSNP:rs6448389)" FT /evidence="ECO:0000269|PubMed:10329428, FT ECO:0000269|PubMed:10610722, ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334" FT /id="VAR_030678" FT CONFLICT 228 FT /note="V -> L (in Ref. 2; AAF31328 and 5; AAL55657)" FT /evidence="ECO:0000305" FT CONFLICT 330 FT /note="T -> V (in Ref. 6; BAC11354)" FT /evidence="ECO:0000305" FT CONFLICT 590..595 FT /note="Missing (in Ref. 6; BAC11354)" FT /evidence="ECO:0000305" FT CONFLICT 620 FT /note="C -> Y (in Ref. 1; AAC98695)" FT /evidence="ECO:0000305" SQ SEQUENCE 690 AA; 75759 MW; 3BDB1920CA92C035 CRC64; MAPWPELGDA QPNPDKYLEG AAGQQPTAPD KSKETNKTDN TEAPVTKIEL LPSYSTATLI DEPTEVDDPW NLPTLQDSGI KWSERDTKGK ILCFFQGIGR LILLLGFLYF FVCSLDILSS AFQLVGGKMA GQFFSNSSIM SNPLLGLVIG VLVTVLVQSS STSTSIVVSM VSSSLLTVRA AIPIIMGANI GTSITNTIVA LMQVGDRSEF RRAFAGATVH DFFNWLSVLV LLPVEVATHY LEIITQLIVE SFHFKNGEDA PDLLKVITKP FTKLIVQLDK KVISQIAMND EKAKNKSLVK IWCKTFTNKT QINVTVPSTA NCTSPSLCWT DGIQNWTMKN VTYKENIAKC QHIFVNFHLP DLAVGTILLI LSLLVLCGCL IMIVKILGSV LKGQVATVIK KTINTDFPFP FAWLTGYLAI LVGAGMTFIV QSSSVFTSAL TPLIGIGVIT IERAYPLTLG SNIGTTTTAI LAALASPGNA LRSSLQIALC HFFFNISGIL LWYPIPFTRL PIRMAKGLGN ISAKYRWFAV FYLIIFFFLI PLTVFGLSLA GWRVLVGVGV PVVFIIILVL CLRLLQSRCP RVLPKKLQNW NFLPLWMRSL KPWDAVVSKF TGCFQMRCCC CCRVCCRACC LLCDCPKCCR CSKCCEDLEE AQEGQDVPVK APETFDNITI SREAQGEVPA SDSKTECTAL //