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O95436

- NPT2B_HUMAN

UniProt

O95436 - NPT2B_HUMAN

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Protein

Sodium-dependent phosphate transport protein 2B

Gene
SLC34A2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in actively transporting phosphate into cells via Na+ cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.

pH dependencei

Optimum pH is 6.6.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei126 – 1272Breakpoint for translocation to form a SLC34A2-ROS1 fusion protein

GO - Molecular functioni

  1. phosphate ion binding Source: UniProtKB
  2. sodium:phosphate symporter activity Source: UniProtKB
  3. sodium-dependent phosphate transmembrane transporter activity Source: UniProtKB
  4. sodium ion binding Source: UniProtKB

GO - Biological processi

  1. aging Source: Ensembl
  2. cellular phosphate ion homeostasis Source: UniProtKB
  3. in utero embryonic development Source: Ensembl
  4. ion transport Source: Reactome
  5. phosphate ion transmembrane transport Source: GOC
  6. phosphate ion transport Source: UniProtKB
  7. response to estradiol Source: Ensembl
  8. response to estrogen Source: UniProtKB
  9. response to fructose Source: Ensembl
  10. sodium ion transmembrane transport Source: GOC
  11. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_19411. Type II Na+/Pi cotransporters.

Protein family/group databases

TCDBi2.A.58.1.4. the phosphate:na(+) symporter (pnas) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transport protein 2B
Short name:
Sodium-phosphate transport protein 2B
Alternative name(s):
Na(+)-dependent phosphate cotransporter 2B
NaPi3b
Sodium/phosphate cotransporter 2B
Short name:
Na(+)/Pi cotransporter 2B
Short name:
NaPi-2b
Solute carrier family 34 member 2
Gene namesi
Name:SLC34A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:11020. SLC34A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 100100Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei101 – 12121Helical; Name=M1; Reviewed predictionAdd
BLAST
Topological domaini122 – 13514Extracellular Reviewed predictionAdd
BLAST
Transmembranei136 – 15621Helical; Name=M2; Reviewed predictionAdd
BLAST
Topological domaini157 – 21256Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei213 – 23321Helical; Name=M3; Reviewed predictionAdd
BLAST
Topological domaini234 – 362129Extracellular Reviewed predictionAdd
BLAST
Transmembranei363 – 38321Helical; Name=M4; Reviewed predictionAdd
BLAST
Topological domaini384 – 40724Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei408 – 42821Helical; Name=M5; Reviewed predictionAdd
BLAST
Topological domaini429 – 48557Extracellular Reviewed predictionAdd
BLAST
Transmembranei486 – 50621Helical; Name=M6; Reviewed predictionAdd
BLAST
Topological domaini507 – 52519Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei526 – 54621Helical; Name=M7; Reviewed predictionAdd
BLAST
Topological domaini547 – 5526Extracellular Reviewed prediction
Transmembranei553 – 57321Helical; Name=M8; Reviewed predictionAdd
BLAST
Topological domaini574 – 689116Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. brush border membrane Source: UniProtKB
  3. integral component of membrane Source: UniProtKB
  4. integral component of plasma membrane Source: UniProtKB
  5. microvillus membrane Source: Ensembl
  6. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Pulmonary alveolar microlithiasis (PALM) [MIM:265100]: Rare disease characterized by the deposition of calcium phosphate microliths throughout the lungs. Most patients are asymptomatic for several years or even for decades and generally, the diagnosis is incidental to clinical investigations unrelated to the disease. Cases with early-onset or rapid progression are rare. A 'sandstorm-appearing' chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal disease varies from the neonatal period to old age and the disease follows a long-term, progressive course, resulting in a slow deterioration of lung functions. Pulmonary alveolar microlithiasis is a recessive monogenic disease with full penetrance.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061G → R in PALM. 1 Publication
VAR_030677
A chromosomal aberration involving SLC34A2 is found in a glioblastoma multiforme cell line U-118MG. Results in the formation of a SLC34A2-ROS1 chimeric protein that retains a constitutive kinase activity.1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi265100. phenotype.
Orphaneti60025. Pulmonary alveolar microlithiasis.
PharmGKBiPA35888.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 690690Sodium-dependent phosphate transport protein 2BPRO_0000068613Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi295 – 2951N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi303 ↔ 350 By similarity
Glycosylationi308 – 3081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi313 – 3131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi321 – 3211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi340 – 3401N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO95436.
PaxDbiO95436.
PRIDEiO95436.

PTM databases

PhosphoSiteiO95436.

Expressioni

Tissue specificityi

Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium.2 Publications

Inductioni

Down-regulated by EGF.1 Publication

Gene expression databases

ArrayExpressiO95436.
BgeeiO95436.
CleanExiHS_SLC34A2.
GenevestigatoriO95436.

Organism-specific databases

HPAiHPA037989.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371483.

Structurei

3D structure databases

ProteinModelPortaliO95436.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi464 – 4674Poly-Thr
Compositional biasi612 – 64433Cys-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1283.
HOGENOMiHOG000006550.
HOVERGENiHBG006527.
InParanoidiO95436.
KOiK14683.
OMAiKTECTAL.
OrthoDBiEOG72ZCDP.
PhylomeDBiO95436.
TreeFamiTF313981.

Family and domain databases

InterProiIPR003841. Na/Pi_transpt.
[Graphical view]
PfamiPF02690. Na_Pi_cotrans. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01013. 2a58. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95436-1) [UniParc]FASTAAdd to Basket

Also known as: NaPi-3b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAPWPELGDA QPNPDKYLEG AAGQQPTAPD KSKETNKTDN TEAPVTKIEL    50
LPSYSTATLI DEPTEVDDPW NLPTLQDSGI KWSERDTKGK ILCFFQGIGR 100
LILLLGFLYF FVCSLDILSS AFQLVGGKMA GQFFSNSSIM SNPLLGLVIG 150
VLVTVLVQSS STSTSIVVSM VSSSLLTVRA AIPIIMGANI GTSITNTIVA 200
LMQVGDRSEF RRAFAGATVH DFFNWLSVLV LLPVEVATHY LEIITQLIVE 250
SFHFKNGEDA PDLLKVITKP FTKLIVQLDK KVISQIAMND EKAKNKSLVK 300
IWCKTFTNKT QINVTVPSTA NCTSPSLCWT DGIQNWTMKN VTYKENIAKC 350
QHIFVNFHLP DLAVGTILLI LSLLVLCGCL IMIVKILGSV LKGQVATVIK 400
KTINTDFPFP FAWLTGYLAI LVGAGMTFIV QSSSVFTSAL TPLIGIGVIT 450
IERAYPLTLG SNIGTTTTAI LAALASPGNA LRSSLQIALC HFFFNISGIL 500
LWYPIPFTRL PIRMAKGLGN ISAKYRWFAV FYLIIFFFLI PLTVFGLSLA 550
GWRVLVGVGV PVVFIIILVL CLRLLQSRCP RVLPKKLQNW NFLPLWMRSL 600
KPWDAVVSKF TGCFQMRCCC CCRVCCRACC LLCDCPKCCR CSKCCEDLEE 650
AQEGQDVPVK APETFDNITI SREAQGEVPA SDSKTECTAL 690
Length:690
Mass (Da):75,759
Last modified:November 30, 2010 - v3
Checksum:i3BDB1920CA92C035
GO
Isoform 2 (identifier: O95436-2) [UniParc]FASTAAdd to Basket

Also known as: NaPi-2b, NaPi-IIb

The sequence of this isoform differs from the canonical sequence as follows:
     38-39: TD → N

Show »
Length:689
Mass (Da):75,657
Checksum:iB8D40075B1266490
GO

Sequence cautioni

The sequence BAC11354.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451V → A.
Corresponds to variant rs35426730 [ dbSNP | Ensembl ].
VAR_034156
Natural varianti106 – 1061G → R in PALM. 1 Publication
VAR_030677
Natural varianti634 – 6341D → G.4 Publications
Corresponds to variant rs6448389 [ dbSNP | Ensembl ].
VAR_030678

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei38 – 392TD → N in isoform 2. VSP_016755

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti228 – 2281V → L in AAF31328. 1 Publication
Sequence conflicti228 – 2281V → L in AAL55657. 1 Publication
Sequence conflicti330 – 3301T → V in BAC11354. 1 Publication
Sequence conflicti590 – 5956Missing in BAC11354. 1 Publication
Sequence conflicti620 – 6201C → Y in AAC98695. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF111856 mRNA. Translation: AAC98695.1.
AF146796 mRNA. Translation: AAF31328.1.
AC092436 Genomic DNA. No translation available.
BC142704 mRNA. Translation: AAI42705.1.
BC146666 mRNA. Translation: AAI46667.1.
AH011306 Genomic DNA. Translation: AAL55657.1.
AK075015 mRNA. Translation: BAC11354.1. Different initiation.
CCDSiCCDS3435.1. [O95436-1]
CCDS54750.1. [O95436-2]
RefSeqiNP_001171469.1. NM_001177998.1.
NP_001171470.1. NM_001177999.1.
NP_006415.2. NM_006424.2.
UniGeneiHs.479372.

Genome annotation databases

EnsembliENST00000382051; ENSP00000371483; ENSG00000157765. [O95436-1]
ENST00000503434; ENSP00000423021; ENSG00000157765. [O95436-2]
ENST00000504570; ENSP00000425501; ENSG00000157765. [O95436-2]
GeneIDi10568.
KEGGihsa:10568.
UCSCiuc003grr.3. human. [O95436-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF111856 mRNA. Translation: AAC98695.1 .
AF146796 mRNA. Translation: AAF31328.1 .
AC092436 Genomic DNA. No translation available.
BC142704 mRNA. Translation: AAI42705.1 .
BC146666 mRNA. Translation: AAI46667.1 .
AH011306 Genomic DNA. Translation: AAL55657.1 .
AK075015 mRNA. Translation: BAC11354.1 . Different initiation.
CCDSi CCDS3435.1. [O95436-1 ]
CCDS54750.1. [O95436-2 ]
RefSeqi NP_001171469.1. NM_001177998.1.
NP_001171470.1. NM_001177999.1.
NP_006415.2. NM_006424.2.
UniGenei Hs.479372.

3D structure databases

ProteinModelPortali O95436.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000371483.

Protein family/group databases

TCDBi 2.A.58.1.4. the phosphate:na(+) symporter (pnas) family.

PTM databases

PhosphoSitei O95436.

Proteomic databases

MaxQBi O95436.
PaxDbi O95436.
PRIDEi O95436.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382051 ; ENSP00000371483 ; ENSG00000157765 . [O95436-1 ]
ENST00000503434 ; ENSP00000423021 ; ENSG00000157765 . [O95436-2 ]
ENST00000504570 ; ENSP00000425501 ; ENSG00000157765 . [O95436-2 ]
GeneIDi 10568.
KEGGi hsa:10568.
UCSCi uc003grr.3. human. [O95436-1 ]

Organism-specific databases

CTDi 10568.
GeneCardsi GC04P025657.
HGNCi HGNC:11020. SLC34A2.
HPAi HPA037989.
MIMi 265100. phenotype.
604217. gene.
neXtProti NX_O95436.
Orphaneti 60025. Pulmonary alveolar microlithiasis.
PharmGKBi PA35888.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1283.
HOGENOMi HOG000006550.
HOVERGENi HBG006527.
InParanoidi O95436.
KOi K14683.
OMAi KTECTAL.
OrthoDBi EOG72ZCDP.
PhylomeDBi O95436.
TreeFami TF313981.

Enzyme and pathway databases

Reactomei REACT_19411. Type II Na+/Pi cotransporters.

Miscellaneous databases

ChiTaRSi SLC34A2. human.
GeneWikii SLC34A2.
GenomeRNAii 10568.
NextBioi 40109.
PROi O95436.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95436.
Bgeei O95436.
CleanExi HS_SLC34A2.
Genevestigatori O95436.

Family and domain databases

InterProi IPR003841. Na/Pi_transpt.
[Graphical view ]
Pfami PF02690. Na_Pi_cotrans. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01013. 2a58. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine."
    Feild J.A., Zhang L., Brun K.A., Brooks D.P., Edwards R.M.
    Biochem. Biophys. Res. Commun. 258:578-582(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY, VARIANT GLY-634.
    Tissue: Lung and Small intestine.
  2. "Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2)."
    Xu H., Bai L., Collins J.F., Ghishan F.K.
    Genomics 62:281-284(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, VARIANT GLY-634.
    Tissue: Small intestine.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLY-634.
  5. "Regulation of the human sodium-phosphate cotransporter NaPi-IIb gene promoter by epidermal growth factor."
    Xu H., Collins J.F., Bai L., Kiela P.R., Ghishan F.K.
    Am. J. Physiol. 280:C628-C636(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-592 (ISOFORM 2), INDUCTION.
    Tissue: Intestine.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 266-690, VARIANT GLY-634.
    Tissue: Ovarian carcinoma.
  7. "Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)."
    Charest A., Lane K., McMahon K., Park J., Preisinger E., Conroy H., Housman D.
    Genes Chromosomes Cancer 37:58-71(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISEASE, CHROMOSOMAL TRANSLOCATION WITH ROS1.
  8. "Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis."
    Corut A., Senyigit A., Ugur S.A., Altin S., Ozcelik U., Calisir H., Yildirim Z., Gocmen A., Tolun A.
    Am. J. Hum. Genet. 79:650-656(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PALM ARG-106.

Entry informationi

Entry nameiNPT2B_HUMAN
AccessioniPrimary (citable) accession number: O95436
Secondary accession number(s): A5PL17
, Q8N2K2, Q8WYA9, Q9P0V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 30, 2010
Last modified: September 3, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi