ID   PPN_HUMAN               Reviewed;        1278 AA.
AC   O95428; B4DES8; B4DGE6; Q659F2; Q6UXJ4; Q6ZNM1; Q6ZUJ0; Q7Z681; Q8IVU0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 4.
DT   24-JAN-2024, entry version 162.
DE   RecName: Full=Papilin;
DE   Flags: Precursor;
GN   Name=PAPLN; ORFNames=UNQ2420/PRO4977;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT MET-1201.
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), AND NUCLEOTIDE
RP   SEQUENCE [LARGE SCALE MRNA] OF 800-1217 (ISOFORM 4).
RC   TISSUE=Amygdala, Cerebellum, and Synovial cell;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-896.
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA   Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA   Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA   Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA   Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA   Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA   Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA   Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA   Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA   Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA   Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA   Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA   Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA   Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 81-302 (ISOFORM 6), AND
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-1278 (ISOFORM 1).
RC   TISSUE=Liver, and Testis;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 620-1278 (ISOFORM 1).
RC   TISSUE=Spleen;
RA   Jikuya H., Takano J., Kikuno R., Nagase T., Ohara O.;
RT   "The nucleotide sequence of a long cDNA clone isolated from human spleen.";
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=6;
CC       Name=1;
CC         IsoId=O95428-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O95428-2; Sequence=VSP_032269, VSP_032272;
CC       Name=5;
CC         IsoId=O95428-5; Sequence=VSP_037596;
CC       Name=6;
CC         IsoId=O95428-6; Sequence=VSP_037595;
CC       Name=3;
CC         IsoId=O95428-3; Sequence=VSP_032270, VSP_032271;
CC       Name=4;
CC         IsoId=O95428-4; Sequence=VSP_032273, VSP_032274;
CC   -!- SIMILARITY: Belongs to the papilin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC97963.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAC86235.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAG57189.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAG57189.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAG57757.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=CAH56406.1; Type=Miscellaneous discrepancy; Note=Partially unspliced mRNA.; Evidence={ECO:0000305};
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DR   EMBL; AY358330; AAQ88696.1; -; mRNA.
DR   EMBL; AK125658; BAC86235.1; ALT_INIT; mRNA.
DR   EMBL; AK294560; BAG57757.1; ALT_INIT; mRNA.
DR   EMBL; AK293773; BAG57189.1; ALT_SEQ; mRNA.
DR   EMBL; AC004846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF109907; AAC97963.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC042057; AAH42057.1; -; mRNA.
DR   EMBL; AL110280; CAH56406.1; ALT_SEQ; mRNA.
DR   EMBL; BX470414; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BX537757; CAD97826.1; -; mRNA.
DR   EMBL; AK131073; BAC85123.1; -; mRNA.
DR   CCDS; CCDS32114.1; -. [O95428-6]
DR   CCDS; CCDS91898.1; -. [O95428-1]
DR   CCDS; CCDS91899.1; -. [O95428-5]
DR   RefSeq; NP_775733.3; NM_173462.3. [O95428-6]
DR   RefSeq; XP_011535592.1; XM_011537290.2.
DR   RefSeq; XP_011535593.1; XM_011537291.2. [O95428-1]
DR   RefSeq; XP_011535594.1; XM_011537292.2. [O95428-1]
DR   AlphaFoldDB; O95428; -.
DR   SMR; O95428; -.
DR   BioGRID; 124645; 73.
DR   IntAct; O95428; 9.
DR   STRING; 9606.ENSP00000345395; -.
DR   MEROPS; I02.972; -.
DR   GlyCosmos; O95428; 11 sites, 3 glycans.
DR   GlyGen; O95428; 18 sites, 4 O-linked glycans (18 sites).
DR   iPTMnet; O95428; -.
DR   PhosphoSitePlus; O95428; -.
DR   BioMuta; PAPLN; -.
DR   jPOST; O95428; -.
DR   MassIVE; O95428; -.
DR   PaxDb; 9606-ENSP00000345395; -.
DR   PeptideAtlas; O95428; -.
DR   ProteomicsDB; 50869; -. [O95428-1]
DR   ProteomicsDB; 50870; -. [O95428-2]
DR   ProteomicsDB; 50871; -. [O95428-3]
DR   ProteomicsDB; 50872; -. [O95428-4]
DR   ProteomicsDB; 50873; -. [O95428-5]
DR   ProteomicsDB; 50874; -. [O95428-6]
DR   Antibodypedia; 63258; 133 antibodies from 16 providers.
DR   DNASU; 89932; -.
DR   Ensembl; ENST00000340738.9; ENSP00000345395.5; ENSG00000100767.17. [O95428-6]
DR   Ensembl; ENST00000554301.5; ENSP00000451803.1; ENSG00000100767.17. [O95428-1]
DR   Ensembl; ENST00000555445.5; ENSP00000451729.1; ENSG00000100767.17. [O95428-5]
DR   Ensembl; ENST00000644200.2; ENSP00000495882.2; ENSG00000100767.17. [O95428-1]
DR   GeneID; 89932; -.
DR   KEGG; hsa:89932; -.
DR   MANE-Select; ENST00000644200.2; ENSP00000495882.2; NM_001365906.3; NP_001352835.1.
DR   UCSC; uc001xnw.5; human. [O95428-1]
DR   AGR; HGNC:19262; -.
DR   CTD; 89932; -.
DR   DisGeNET; 89932; -.
DR   GeneCards; PAPLN; -.
DR   HGNC; HGNC:19262; PAPLN.
DR   HPA; ENSG00000100767; Low tissue specificity.
DR   MIM; 617785; gene.
DR   neXtProt; NX_O95428; -.
DR   OpenTargets; ENSG00000100767; -.
DR   PharmGKB; PA134914395; -.
DR   VEuPathDB; HostDB:ENSG00000100767; -.
DR   eggNOG; KOG3510; Eukaryota.
DR   eggNOG; KOG4597; Eukaryota.
DR   GeneTree; ENSGT00940000156891; -.
DR   HOGENOM; CLU_000660_7_0_1; -.
DR   InParanoid; O95428; -.
DR   OMA; KLDSGWF; -.
DR   OrthoDB; 2910701at2759; -.
DR   PhylomeDB; O95428; -.
DR   TreeFam; TF316874; -.
DR   PathwayCommons; O95428; -.
DR   SignaLink; O95428; -.
DR   BioGRID-ORCS; 89932; 6 hits in 1148 CRISPR screens.
DR   ChiTaRS; PAPLN; human.
DR   GeneWiki; PAPLN; -.
DR   GenomeRNAi; 89932; -.
DR   Pharos; O95428; Tbio.
DR   PRO; PR:O95428; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   RNAct; O95428; Protein.
DR   Bgee; ENSG00000100767; Expressed in tibial nerve and 162 other cell types or tissues.
DR   ExpressionAtlas; O95428; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR   CDD; cd22635; Kunitz_papilin; 1.
DR   Gene3D; 2.60.120.830; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR   InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR   InterPro; IPR045371; ADAMTS_CR_3.
DR   InterPro; IPR010294; ADAMTS_spacer1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR002223; Kunitz_BPTI.
DR   InterPro; IPR036880; Kunitz_BPTI_sf.
DR   InterPro; IPR010909; PLAC.
DR   InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR   PANTHER; PTHR13723:SF179; PAPILIN; 1.
DR   Pfam; PF19236; ADAMTS_CR_3; 1.
DR   Pfam; PF05986; ADAMTS_spacer1; 1.
DR   Pfam; PF07679; I-set; 3.
DR   Pfam; PF00014; Kunitz_BPTI; 1.
DR   Pfam; PF16626; Papilin_u7; 1.
DR   Pfam; PF08686; PLAC; 1.
DR   Pfam; PF19030; TSP1_ADAMTS; 4.
DR   Pfam; PF00090; TSP_1; 1.
DR   PRINTS; PR01857; ADAMTSFAMILY.
DR   PRINTS; PR00759; BASICPTASE.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 3.
DR   SMART; SM00406; IGv; 3.
DR   SMART; SM00131; KU; 1.
DR   SMART; SM00209; TSP1; 5.
DR   SUPFAM; SSF57362; BPTI-like; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 3.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR   PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR   PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR   PROSITE; PS50835; IG_LIKE; 3.
DR   PROSITE; PS50900; PLAC; 1.
DR   PROSITE; PS50092; TSP1; 5.
DR   Genevisible; O95428; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Disulfide bond; Immunoglobulin domain;
KW   Protease inhibitor; Reference proteome; Repeat; Secreted;
KW   Serine protease inhibitor; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..1278
FT                   /note="Papilin"
FT                   /id="PRO_0000324550"
FT   DOMAIN          26..80
FT                   /note="TSP type-1 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DOMAIN          304..361
FT                   /note="TSP type-1 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DOMAIN          362..421
FT                   /note="TSP type-1 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DOMAIN          423..481
FT                   /note="TSP type-1 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DOMAIN          484..539
FT                   /note="TSP type-1 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT   DOMAIN          754..804
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DOMAIN          900..995
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          1033..1128
FT                   /note="Ig-like C2-type 2"
FT   DOMAIN          1133..1218
FT                   /note="Ig-like C2-type 3"
FT   DOMAIN          1231..1270
FT                   /note="PLAC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00233"
FT   REGION          544..632
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          805..901
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1014..1042
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        582..598
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        606..621
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        818..843
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        38..74
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..79
FT                   /evidence="ECO:0000250"
FT   DISULFID        53..64
FT                   /evidence="ECO:0000250"
FT   DISULFID        316..355
FT                   /evidence="ECO:0000250"
FT   DISULFID        320..360
FT                   /evidence="ECO:0000250"
FT   DISULFID        331..343
FT                   /evidence="ECO:0000250"
FT   DISULFID        754..804
FT                   /evidence="ECO:0000250"
FT   DISULFID        763..787
FT                   /evidence="ECO:0000250"
FT   DISULFID        779..800
FT                   /evidence="ECO:0000250"
FT   DISULFID        931..978
FT                   /evidence="ECO:0000250"
FT   DISULFID        1065..1112
FT                   /evidence="ECO:0000250"
FT   DISULFID        1154..1202
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         1..801
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12975309"
FT                   /id="VSP_032269"
FT   VAR_SEQ         124..129
FT                   /note="GENFYY -> VLGLQA (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_032270"
FT   VAR_SEQ         130..1278
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_032271"
FT   VAR_SEQ         197..223
FT                   /note="Missing (in isoform 6)"
FT                   /evidence="ECO:0000303|PubMed:17974005"
FT                   /id="VSP_037595"
FT   VAR_SEQ         749..764
FT                   /note="Missing (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_037596"
FT   VAR_SEQ         802..907
FT                   /note="SSCQGSLHGPRRPQPGASGRSTHTDGGGSSPAGEQEPSQHRTGAAVQRKPWP
FT                   SGGLWRQDQQPGPGEAPHTQAFGEWPWGQELGSRAPGLGGDAGSPAPPFHSSSY -> M
FT                   GPVVPSLGLLEGAPTRMVAAAVLQASRNPASTGQGPRCRESPGLLVVSGGKTNSLGQGR
FT                   PPTPRPLENGHGGRSLGPGPLDWVEMPDHQRHPSTAPPTDLTSHLS (in isoform
FT                   2)"
FT                   /evidence="ECO:0000303|PubMed:12975309"
FT                   /id="VSP_032272"
FT   VAR_SEQ         1088..1109
FT                   /note="RHQLQPDGSLVISRVAVEDGGF -> STHRPAQGPWQGLRRPARAGQL (in
FT                   isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_032273"
FT   VAR_SEQ         1110..1278
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_032274"
FT   VARIANT         33
FT                   /note="S -> G (in dbSNP:rs2280792)"
FT                   /id="VAR_039815"
FT   VARIANT         191
FT                   /note="A -> T (in dbSNP:rs741842)"
FT                   /id="VAR_039816"
FT   VARIANT         356
FT                   /note="N -> H (in dbSNP:rs17126331)"
FT                   /id="VAR_039817"
FT   VARIANT         443
FT                   /note="V -> I (in dbSNP:rs17126352)"
FT                   /id="VAR_039818"
FT   VARIANT         461
FT                   /note="A -> V (in dbSNP:rs17126354)"
FT                   /id="VAR_039819"
FT   VARIANT         628
FT                   /note="H -> R (in dbSNP:rs17182244)"
FT                   /id="VAR_039820"
FT   VARIANT         723
FT                   /note="Q -> H (in dbSNP:rs2242616)"
FT                   /id="VAR_039821"
FT   VARIANT         896
FT                   /note="G -> R (in dbSNP:rs177386)"
FT                   /evidence="ECO:0000269|PubMed:12508121"
FT                   /id="VAR_039822"
FT   VARIANT         1192
FT                   /note="L -> V (in dbSNP:rs2107731)"
FT                   /id="VAR_039823"
FT   VARIANT         1201
FT                   /note="T -> M (in dbSNP:rs4903104)"
FT                   /evidence="ECO:0000269|PubMed:12975309"
FT                   /id="VAR_039824"
FT   VARIANT         1260
FT                   /note="S -> T (in dbSNP:rs11626824)"
FT                   /id="VAR_039825"
FT   CONFLICT        326
FT                   /note="S -> P (in Ref. 2; BAG57757)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        693
FT                   /note="M -> R (in Ref. 2; BAG57757, 5; CAD97826 and 6;
FT                   BAC85123)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1162
FT                   /note="N -> D (in Ref. 2; BAG57189)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1229
FT                   /note="R -> K (in Ref. 5; CAD97826)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1278 AA;  137700 MW;  A8DED3CADB0D70C1 CRC64;
     MRLLLLVPLL LAPAPGSSAP KVRRQSDTWG PWSQWSPCSR TCGGGVSFRE RPCYSQRRDG
     GSSCVGPARS HRSCRTESCP DGARDFRAEQ CAEFDGAEFQ GRRYRWLPYY SAPNKCELNC
     IPKGENFYYK HREAVVDGTP CEPGKRDVCV DGSCRVVGCD HELDSSKQED KCLRCGGDGT
     TCYPVAGTFD ANDLSRGYNQ ILIVPMGATS ILIDEAAASR NFLAVKNVRG EYYLNGHWTI
     EAARALPAAS TILHYERGAE GDLAPERLHA RGPTSEPLVI ELISQEPNPG VHYEYHLPLR
     RPSPGFSWSH GSWSDCSAEC GGGHQSRLVF CTIDHEAYPD HMCQRQPRPA DRRSCNLHPC
     PETKRWKAGP WAPCSASCGG GSQSRSVYCI SSDGAGIQEA VEEAECAGLP GKPPAIQACN
     LQRCAAWSPE PWGECSVSCG VGVRKRSVTC RGERGSLLHT AACSLEDRPP LTEPCVHEDC
     PLLSDQAWHV GTWGLCSKSC SSGTRRRQVI CAIGPPSHCG SLQHSKPVDV EPCNTQPCHL
     PQEVPSMQDV HTPASNPWMP LGPQESPASD SRGQWWAAQE HPSARGDHRG ERGDPRGDQG
     THLSALGPAP SLQQPPYQQP LRSGSGPHDC RHSPHGCCPD GHTASLGPQW QGCPGAPCQQ
     SRYGCCPDRV SVAEGPHHAG CTKSYGGDST GGMPRSRAVA STVHNTHQPQ AQQNEPSECR
     GSQFGCCYDN VATAAGPLGE GCVGQPSHAY PVRCLLPSAH GSCADWAARW YFVASVGQCN
     RFWYGGCHGN ANNFASEQEC MSSCQGSLHG PRRPQPGASG RSTHTDGGGS SPAGEQEPSQ
     HRTGAAVQRK PWPSGGLWRQ DQQPGPGEAP HTQAFGEWPW GQELGSRAPG LGGDAGSPAP
     PFHSSSYRIS LAGVEPSLVQ AALGQLVRLS CSDDTAPESQ AAWQKDGQPI SSDRHRLQFD
     GSLIIHPLQA EDAGTYSCGS TRPGRDSQKI QLRIIGGDMA VLSEAELSRF PQPRDPAQDF
     GQAGAAGPLG AIPSSHPQPA NRLRLDQNQP RVVDASPGQR IRMTCRAEGF PPPAIEWQRD
     GQPVSSPRHQ LQPDGSLVIS RVAVEDGGFY TCVAFNGQDR DQRWVQLRVL GELTISGLPP
     TVTVPEGDTA RLLCVVAGES VNIRWSRNGL PVQADGHRVH QSPDGTLLIY NLRARDEGSY
     TCSAYQGSQA VSRSTEVKVV SPAPTAQPRD PGRDCVDQPE LANCDLILQA QLCGNEYYSS
     FCCASCSRFQ PHAQPIWQ
//