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O95428

- PPN_HUMAN

UniProt

O95428 - PPN_HUMAN

Protein

Papilin

Gene

PAPLN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 4 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. metalloendopeptidase activity Source: InterPro
    2. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
    3. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI02.972.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Papilin
    Gene namesi
    Name:PAPLN
    ORF Names:UNQ2420/PRO4977
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:19262. PAPLN.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. basement membrane Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134914395.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 12781260PapilinPRO_0000324550Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi38 ↔ 74By similarity
    Disulfide bondi42 ↔ 79By similarity
    Disulfide bondi53 ↔ 64By similarity
    Disulfide bondi316 ↔ 355By similarity
    Disulfide bondi320 ↔ 360By similarity
    Disulfide bondi331 ↔ 343By similarity
    Disulfide bondi754 ↔ 804By similarity
    Disulfide bondi763 ↔ 787By similarity
    Disulfide bondi779 ↔ 800By similarity
    Disulfide bondi931 ↔ 978By similarity
    Disulfide bondi1065 ↔ 1112By similarity
    Disulfide bondi1154 ↔ 1202By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiO95428.
    PRIDEiO95428.

    PTM databases

    PhosphoSiteiO95428.

    Expressioni

    Gene expression databases

    ArrayExpressiO95428.
    BgeeiO95428.
    CleanExiHS_PAPLN.
    GenevestigatoriO95428.

    Organism-specific databases

    HPAiHPA048682.

    Structurei

    3D structure databases

    ProteinModelPortaliO95428.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 8055TSP type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini304 – 36158TSP type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini362 – 42160TSP type-1 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini423 – 48159TSP type-1 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini484 – 53956TSP type-1 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini754 – 80451BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd
    BLAST
    Domaini900 – 99596Ig-like C2-type 1Add
    BLAST
    Domaini1033 – 112896Ig-like C2-type 2Add
    BLAST
    Domaini1133 – 121886Ig-like C2-type 3Add
    BLAST
    Domaini1231 – 127040PLACPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the papilin family.Curated
    Contains 1 BPTI/Kunitz inhibitor domain.PROSITE-ProRule annotation
    Contains 1 PLAC domain.PROSITE-ProRule annotation
    Contains 5 TSP type-1 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG242665.
    HOVERGENiHBG108281.
    OMAiSVNIRWS.
    OrthoDBiEOG7W419Z.
    PhylomeDBiO95428.
    TreeFamiTF316874.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    4.10.410.10. 1 hit.
    InterProiIPR010294. ADAM_spacer1.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR013273. Peptidase_M12B_ADAM-TS.
    IPR010909. PLAC.
    IPR002223. Prot_inh_Kunz-m.
    IPR020901. Prtase_inh_Kunz-CS.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view]
    PfamiPF05986. ADAM_spacer1. 1 hit.
    PF07679. I-set. 3 hits.
    PF00014. Kunitz_BPTI. 1 hit.
    PF08686. PLAC. 1 hit.
    PF00090. TSP_1. 5 hits.
    [Graphical view]
    PRINTSiPR01857. ADAMTSFAMILY.
    PR00759. BASICPTASE.
    SMARTiSM00408. IGc2. 3 hits.
    SM00131. KU. 1 hit.
    SM00209. TSP1. 5 hits.
    [Graphical view]
    SUPFAMiSSF57362. SSF57362. 1 hit.
    SSF82895. SSF82895. 5 hits.
    PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
    PS50279. BPTI_KUNITZ_2. 1 hit.
    PS50835. IG_LIKE. 3 hits.
    PS50900. PLAC. 1 hit.
    PS50092. TSP1. 5 hits.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95428-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRLLLLVPLL LAPAPGSSAP KVRRQSDTWG PWSQWSPCSR TCGGGVSFRE     50
    RPCYSQRRDG GSSCVGPARS HRSCRTESCP DGARDFRAEQ CAEFDGAEFQ 100
    GRRYRWLPYY SAPNKCELNC IPKGENFYYK HREAVVDGTP CEPGKRDVCV 150
    DGSCRVVGCD HELDSSKQED KCLRCGGDGT TCYPVAGTFD ANDLSRGYNQ 200
    ILIVPMGATS ILIDEAAASR NFLAVKNVRG EYYLNGHWTI EAARALPAAS 250
    TILHYERGAE GDLAPERLHA RGPTSEPLVI ELISQEPNPG VHYEYHLPLR 300
    RPSPGFSWSH GSWSDCSAEC GGGHQSRLVF CTIDHEAYPD HMCQRQPRPA 350
    DRRSCNLHPC PETKRWKAGP WAPCSASCGG GSQSRSVYCI SSDGAGIQEA 400
    VEEAECAGLP GKPPAIQACN LQRCAAWSPE PWGECSVSCG VGVRKRSVTC 450
    RGERGSLLHT AACSLEDRPP LTEPCVHEDC PLLSDQAWHV GTWGLCSKSC 500
    SSGTRRRQVI CAIGPPSHCG SLQHSKPVDV EPCNTQPCHL PQEVPSMQDV 550
    HTPASNPWMP LGPQESPASD SRGQWWAAQE HPSARGDHRG ERGDPRGDQG 600
    THLSALGPAP SLQQPPYQQP LRSGSGPHDC RHSPHGCCPD GHTASLGPQW 650
    QGCPGAPCQQ SRYGCCPDRV SVAEGPHHAG CTKSYGGDST GGMPRSRAVA 700
    STVHNTHQPQ AQQNEPSECR GSQFGCCYDN VATAAGPLGE GCVGQPSHAY 750
    PVRCLLPSAH GSCADWAARW YFVASVGQCN RFWYGGCHGN ANNFASEQEC 800
    MSSCQGSLHG PRRPQPGASG RSTHTDGGGS SPAGEQEPSQ HRTGAAVQRK 850
    PWPSGGLWRQ DQQPGPGEAP HTQAFGEWPW GQELGSRAPG LGGDAGSPAP 900
    PFHSSSYRIS LAGVEPSLVQ AALGQLVRLS CSDDTAPESQ AAWQKDGQPI 950
    SSDRHRLQFD GSLIIHPLQA EDAGTYSCGS TRPGRDSQKI QLRIIGGDMA 1000
    VLSEAELSRF PQPRDPAQDF GQAGAAGPLG AIPSSHPQPA NRLRLDQNQP 1050
    RVVDASPGQR IRMTCRAEGF PPPAIEWQRD GQPVSSPRHQ LQPDGSLVIS 1100
    RVAVEDGGFY TCVAFNGQDR DQRWVQLRVL GELTISGLPP TVTVPEGDTA 1150
    RLLCVVAGES VNIRWSRNGL PVQADGHRVH QSPDGTLLIY NLRARDEGSY 1200
    TCSAYQGSQA VSRSTEVKVV SPAPTAQPRD PGRDCVDQPE LANCDLILQA 1250
    QLCGNEYYSS FCCASCSRFQ PHAQPIWQ 1278
    Length:1,278
    Mass (Da):137,700
    Last modified:July 7, 2009 - v4
    Checksum:iA8DED3CADB0D70C1
    GO
    Isoform 2 (identifier: O95428-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-801: Missing.
         802-907: SSCQGSLHGP...PAPPFHSSSY → MGPVVPSLGL...PPTDLTSHLS

    Note: No experimental confirmation available.

    Show »
    Length:477
    Mass (Da):51,082
    Checksum:i1979A1F2428DE816
    GO
    Isoform 5 (identifier: O95428-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         749-764: Missing.

    Show »
    Length:1,262
    Mass (Da):136,073
    Checksum:i3D334E4C30CDE94F
    GO
    Isoform 6 (identifier: O95428-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         197-223: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,251
    Mass (Da):134,840
    Checksum:i149C41975845C4E9
    GO
    Isoform 3 (identifier: O95428-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         124-129: GENFYY → VLGLQA
         130-1278: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:129
    Mass (Da):14,368
    Checksum:iD51144A494C12B3B
    GO
    Isoform 4 (identifier: O95428-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1088-1109: RHQLQPDGSLVISRVAVEDGGF → STHRPAQGPWQGLRRPARAGQL
         1110-1278: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,109
    Mass (Da):119,209
    Checksum:iFB23C426C3F47E83
    GO

    Sequence cautioni

    The sequence CAH56406.1 differs from that shown. Reason: Partially unspliced mRNA.
    The sequence BAC86235.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAG57189.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAG57757.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAG57189.1 differs from that shown. Reason: Erroneous termination at position 1216. Translated as Glu.
    The sequence AAC97963.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti326 – 3261S → P in BAG57757. (PubMed:14702039)Curated
    Sequence conflicti693 – 6931M → R in BAG57757. (PubMed:14702039)Curated
    Sequence conflicti693 – 6931M → R in CAD97826. (PubMed:17974005)Curated
    Sequence conflicti693 – 6931M → R in BAC85123. 1 PublicationCurated
    Sequence conflicti1162 – 11621N → D in BAG57189. (PubMed:14702039)Curated
    Sequence conflicti1229 – 12291R → K in CAD97826. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti33 – 331S → G.
    Corresponds to variant rs2280792 [ dbSNP | Ensembl ].
    VAR_039815
    Natural varianti191 – 1911A → T.
    Corresponds to variant rs741842 [ dbSNP | Ensembl ].
    VAR_039816
    Natural varianti356 – 3561N → H.
    Corresponds to variant rs17126331 [ dbSNP | Ensembl ].
    VAR_039817
    Natural varianti443 – 4431V → I.
    Corresponds to variant rs17126352 [ dbSNP | Ensembl ].
    VAR_039818
    Natural varianti461 – 4611A → V.
    Corresponds to variant rs17126354 [ dbSNP | Ensembl ].
    VAR_039819
    Natural varianti628 – 6281H → R.
    Corresponds to variant rs17182244 [ dbSNP | Ensembl ].
    VAR_039820
    Natural varianti723 – 7231Q → H.
    Corresponds to variant rs2242616 [ dbSNP | Ensembl ].
    VAR_039821
    Natural varianti896 – 8961G → R.1 Publication
    Corresponds to variant rs177386 [ dbSNP | Ensembl ].
    VAR_039822
    Natural varianti1192 – 11921L → V.
    Corresponds to variant rs2107731 [ dbSNP | Ensembl ].
    VAR_039823
    Natural varianti1201 – 12011T → M.1 Publication
    Corresponds to variant rs4903104 [ dbSNP | Ensembl ].
    VAR_039824
    Natural varianti1260 – 12601S → T.
    Corresponds to variant rs11626824 [ dbSNP | Ensembl ].
    VAR_039825

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 801801Missing in isoform 2. 1 PublicationVSP_032269Add
    BLAST
    Alternative sequencei124 – 1296GENFYY → VLGLQA in isoform 3. 1 PublicationVSP_032270
    Alternative sequencei130 – 12781149Missing in isoform 3. 1 PublicationVSP_032271Add
    BLAST
    Alternative sequencei197 – 22327Missing in isoform 6. 1 PublicationVSP_037595Add
    BLAST
    Alternative sequencei749 – 76416Missing in isoform 5. 1 PublicationVSP_037596Add
    BLAST
    Alternative sequencei802 – 907106SSCQG…HSSSY → MGPVVPSLGLLEGAPTRMVA AAVLQASRNPASTGQGPRCR ESPGLLVVSGGKTNSLGQGR PPTPRPLENGHGGRSLGPGP LDWVEMPDHQRHPSTAPPTD LTSHLS in isoform 2. 1 PublicationVSP_032272Add
    BLAST
    Alternative sequencei1088 – 110922RHQLQ…EDGGF → STHRPAQGPWQGLRRPARAG QL in isoform 4. 1 PublicationVSP_032273Add
    BLAST
    Alternative sequencei1110 – 1278169Missing in isoform 4. 1 PublicationVSP_032274Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358330 mRNA. Translation: AAQ88696.1.
    AK125658 mRNA. Translation: BAC86235.1. Different initiation.
    AK294560 mRNA. Translation: BAG57757.1. Different initiation.
    AK293773 mRNA. Translation: BAG57189.1. Sequence problems.
    AC004846 Genomic DNA. No translation available.
    AF109907 Genomic DNA. Translation: AAC97963.1. Sequence problems.
    BC042057 mRNA. Translation: AAH42057.1.
    AL110280 mRNA. Translation: CAH56406.1. Sequence problems.
    BX470414 mRNA. No translation available.
    BX537757 mRNA. Translation: CAD97826.1.
    AK131073 mRNA. Translation: BAC85123.1.
    CCDSiCCDS32114.1. [O95428-6]
    RefSeqiNP_775733.3. NM_173462.3. [O95428-6]
    UniGeneiHs.509909.

    Genome annotation databases

    EnsembliENST00000340738; ENSP00000345395; ENSG00000100767. [O95428-6]
    ENST00000554301; ENSP00000451803; ENSG00000100767. [O95428-1]
    ENST00000555445; ENSP00000451729; ENSG00000100767. [O95428-5]
    GeneIDi89932.
    KEGGihsa:89932.
    UCSCiuc001xnw.4. human. [O95428-6]
    uc010arm.3. human. [O95428-2]
    uc010ttx.2. human. [O95428-1]
    uc010tty.2. human. [O95428-5]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358330 mRNA. Translation: AAQ88696.1 .
    AK125658 mRNA. Translation: BAC86235.1 . Different initiation.
    AK294560 mRNA. Translation: BAG57757.1 . Different initiation.
    AK293773 mRNA. Translation: BAG57189.1 . Sequence problems.
    AC004846 Genomic DNA. No translation available.
    AF109907 Genomic DNA. Translation: AAC97963.1 . Sequence problems.
    BC042057 mRNA. Translation: AAH42057.1 .
    AL110280 mRNA. Translation: CAH56406.1 . Sequence problems.
    BX470414 mRNA. No translation available.
    BX537757 mRNA. Translation: CAD97826.1 .
    AK131073 mRNA. Translation: BAC85123.1 .
    CCDSi CCDS32114.1. [O95428-6 ]
    RefSeqi NP_775733.3. NM_173462.3. [O95428-6 ]
    UniGenei Hs.509909.

    3D structure databases

    ProteinModelPortali O95428.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I02.972.

    PTM databases

    PhosphoSitei O95428.

    Proteomic databases

    PaxDbi O95428.
    PRIDEi O95428.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340738 ; ENSP00000345395 ; ENSG00000100767 . [O95428-6 ]
    ENST00000554301 ; ENSP00000451803 ; ENSG00000100767 . [O95428-1 ]
    ENST00000555445 ; ENSP00000451729 ; ENSG00000100767 . [O95428-5 ]
    GeneIDi 89932.
    KEGGi hsa:89932.
    UCSCi uc001xnw.4. human. [O95428-6 ]
    uc010arm.3. human. [O95428-2 ]
    uc010ttx.2. human. [O95428-1 ]
    uc010tty.2. human. [O95428-5 ]

    Organism-specific databases

    CTDi 89932.
    GeneCardsi GC14P073704.
    H-InvDB HIX0019543.
    HIX0037927.
    HGNCi HGNC:19262. PAPLN.
    HPAi HPA048682.
    neXtProti NX_O95428.
    PharmGKBi PA134914395.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG242665.
    HOVERGENi HBG108281.
    OMAi SVNIRWS.
    OrthoDBi EOG7W419Z.
    PhylomeDBi O95428.
    TreeFami TF316874.

    Miscellaneous databases

    ChiTaRSi PAPLN. human.
    GeneWikii PAPLN.
    GenomeRNAii 89932.
    NextBioi 76441.
    PROi O95428.

    Gene expression databases

    ArrayExpressi O95428.
    Bgeei O95428.
    CleanExi HS_PAPLN.
    Genevestigatori O95428.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    4.10.410.10. 1 hit.
    InterProi IPR010294. ADAM_spacer1.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR013273. Peptidase_M12B_ADAM-TS.
    IPR010909. PLAC.
    IPR002223. Prot_inh_Kunz-m.
    IPR020901. Prtase_inh_Kunz-CS.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view ]
    Pfami PF05986. ADAM_spacer1. 1 hit.
    PF07679. I-set. 3 hits.
    PF00014. Kunitz_BPTI. 1 hit.
    PF08686. PLAC. 1 hit.
    PF00090. TSP_1. 5 hits.
    [Graphical view ]
    PRINTSi PR01857. ADAMTSFAMILY.
    PR00759. BASICPTASE.
    SMARTi SM00408. IGc2. 3 hits.
    SM00131. KU. 1 hit.
    SM00209. TSP1. 5 hits.
    [Graphical view ]
    SUPFAMi SSF57362. SSF57362. 1 hit.
    SSF82895. SSF82895. 5 hits.
    PROSITEi PS00280. BPTI_KUNITZ_1. 1 hit.
    PS50279. BPTI_KUNITZ_2. 1 hit.
    PS50835. IG_LIKE. 3 hits.
    PS50900. PLAC. 1 hit.
    PS50092. TSP1. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT MET-1201.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 800-1217 (ISOFORM 4).
      Tissue: Amygdala, Cerebellum and Synovial cell.
    3. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-896.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Ovary.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 81-302 (ISOFORM 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-1278 (ISOFORM 1).
      Tissue: Liver and Testis.
    6. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
      Jikuya H., Takano J., Kikuno R., Nagase T., Ohara O.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 620-1278 (ISOFORM 1).
      Tissue: Spleen.

    Entry informationi

    Entry nameiPPN_HUMAN
    AccessioniPrimary (citable) accession number: O95428
    Secondary accession number(s): B4DES8
    , B4DGE6, Q659F2, Q6UXJ4, Q6ZNM1, Q6ZUJ0, Q7Z681, Q8IVU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 105 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3