O95428 (PPN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Papilin

Gene names

Name:	PAPLN
ORF Names:	UNQ2420/PRO4977

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the papilin family. Contains 1 BPTI/Kunitz inhibitor domain. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 PLAC domain. Contains 5 TSP type-1 domains.
Sequence caution	The sequence AAC97963.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAC86235.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAG57189.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAG57189.1 differs from that shown. Reason: Erroneous termination at position 1216. Translated as Glu. The sequence BAG57757.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAH56406.1 differs from that shown. Reason: Partially unspliced mRNA.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	basement membrane Inferred from electronic annotation. Source: Compara
Molecular_function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro serine-type endopeptidase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O95428-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O95428-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-801: Missing.
     802-907: SSCQGSLHGP...PAPPFHSSSY → MGPVVPSLGL...PPTDLTSHLS

Note: No experimental confirmation available.

Isoform 5 (identifier: O95428-5)

The sequence of this isoform differs from the canonical sequence as follows:
     749-764: Missing.

Isoform 6 (identifier: O95428-6)

The sequence of this isoform differs from the canonical sequence as follows:
     197-223: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: O95428-3)

The sequence of this isoform differs from the canonical sequence as follows:
     124-129: GENFYY → VLGLQA
     130-1278: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: O95428-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1088-1109: RHQLQPDGSLVISRVAVEDGGF → STHRPAQGPWQGLRRPARAGQL
     1110-1278: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 1278	1260	Papilin		PRO_0000324550
Regions
	Domain	26 – 80	55	TSP type-1 1
	Domain	304 – 361	58	TSP type-1 2
	Domain	362 – 421	60	TSP type-1 3
	Domain	423 – 481	59	TSP type-1 4
	Domain	484 – 539	56	TSP type-1 5
	Domain	754 – 804	51	BPTI/Kunitz inhibitor
	Domain	900 – 995	96	Ig-like C2-type 1
	Domain	1033 – 1128	96	Ig-like C2-type 2
	Domain	1133 – 1218	86	Ig-like C2-type 3
	Domain	1231 – 1270	40	PLAC
Amino acid modifications
	Disulfide bond	38 ↔ 74		By similarity
	Disulfide bond	42 ↔ 79		By similarity
	Disulfide bond	53 ↔ 64		By similarity
	Disulfide bond	316 ↔ 355		By similarity
	Disulfide bond	320 ↔ 360		By similarity
	Disulfide bond	331 ↔ 343		By similarity
	Disulfide bond	754 ↔ 804		By similarity
	Disulfide bond	763 ↔ 787		By similarity
	Disulfide bond	779 ↔ 800		By similarity
	Disulfide bond	931 ↔ 978		By similarity
	Disulfide bond	1065 ↔ 1112		By similarity
	Disulfide bond	1154 ↔ 1202		By similarity
Natural variations
	Alternative sequence	1 – 801	801	Missing in isoform 2.		VSP_032269
	Alternative sequence	124 – 129	6	GENFYY → VLGLQA in isoform 3.		VSP_032270
	Alternative sequence	130 – 1278	1149	Missing in isoform 3.		VSP_032271
	Alternative sequence	197 – 223	27	Missing in isoform 6.		VSP_037595
	Alternative sequence	749 – 764	16	Missing in isoform 5.		VSP_037596
	Alternative sequence	802 – 907	106	SSCQG…HSSSY → MGPVVPSLGLLEGAPTRMVA AAVLQASRNPASTGQGPRCR ESPGLLVVSGGKTNSLGQGR PPTPRPLENGHGGRSLGPGP LDWVEMPDHQRHPSTAPPTD LTSHLS in isoform 2.		VSP_032272
	Alternative sequence	1088 – 1109	22	RHQLQ…EDGGF → STHRPAQGPWQGLRRPARAG QL in isoform 4.		VSP_032273
	Alternative sequence	1110 – 1278	169	Missing in isoform 4.		VSP_032274
	Natural variant	33	1	S → G. Corresponds to variant rs2280792 [ dbSNP | Ensembl ].		VAR_039815
	Natural variant	191	1	A → T. Corresponds to variant rs741842 [ dbSNP | Ensembl ].		VAR_039816
	Natural variant	356	1	N → H. Corresponds to variant rs17126331 [ dbSNP | Ensembl ].		VAR_039817
	Natural variant	443	1	V → I. Corresponds to variant rs17126352 [ dbSNP | Ensembl ].		VAR_039818
	Natural variant	461	1	A → V. Corresponds to variant rs17126354 [ dbSNP | Ensembl ].		VAR_039819
	Natural variant	628	1	H → R. Corresponds to variant rs17182244 [ dbSNP | Ensembl ].		VAR_039820
	Natural variant	723	1	Q → H. Corresponds to variant rs2242616 [ dbSNP | Ensembl ].		VAR_039821
	Natural variant	896	1	G → R. Ref.3 Corresponds to variant rs177386 [ dbSNP | Ensembl ].		VAR_039822
	Natural variant	1192	1	L → V. Corresponds to variant rs2107731 [ dbSNP | Ensembl ].		VAR_039823
	Natural variant	1201	1	T → M. Ref.1 Corresponds to variant rs4903104 [ dbSNP | Ensembl ].		VAR_039824
	Natural variant	1260	1	S → T. Corresponds to variant rs11626824 [ dbSNP | Ensembl ].		VAR_039825
Experimental info
	Sequence conflict	326	1	S → P in BAG57757. Ref.2
	Sequence conflict	693	1	M → R in BAG57757. Ref.2
	Sequence conflict	693	1	M → R in CAD97826. Ref.5
	Sequence conflict	693	1	M → R in BAC85123. Ref.6
	Sequence conflict	1162	1	N → D in BAG57189. Ref.2
	Sequence conflict	1229	1	R → K in CAD97826. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 7, 2009. Version 4. Checksum: A8DED3CADB0D70C1	FASTA	1,278	137,700
	10 20 30 40 50 60 MRLLLLVPLL LAPAPGSSAP KVRRQSDTWG PWSQWSPCSR TCGGGVSFRE RPCYSQRRDG 70 80 90 100 110 120 GSSCVGPARS HRSCRTESCP DGARDFRAEQ CAEFDGAEFQ GRRYRWLPYY SAPNKCELNC 130 140 150 160 170 180 IPKGENFYYK HREAVVDGTP CEPGKRDVCV DGSCRVVGCD HELDSSKQED KCLRCGGDGT 190 200 210 220 230 240 TCYPVAGTFD ANDLSRGYNQ ILIVPMGATS ILIDEAAASR NFLAVKNVRG EYYLNGHWTI 250 260 270 280 290 300 EAARALPAAS TILHYERGAE GDLAPERLHA RGPTSEPLVI ELISQEPNPG VHYEYHLPLR 310 320 330 340 350 360 RPSPGFSWSH GSWSDCSAEC GGGHQSRLVF CTIDHEAYPD HMCQRQPRPA DRRSCNLHPC 370 380 390 400 410 420 PETKRWKAGP WAPCSASCGG GSQSRSVYCI SSDGAGIQEA VEEAECAGLP GKPPAIQACN 430 440 450 460 470 480 LQRCAAWSPE PWGECSVSCG VGVRKRSVTC RGERGSLLHT AACSLEDRPP LTEPCVHEDC 490 500 510 520 530 540 PLLSDQAWHV GTWGLCSKSC SSGTRRRQVI CAIGPPSHCG SLQHSKPVDV EPCNTQPCHL 550 560 570 580 590 600 PQEVPSMQDV HTPASNPWMP LGPQESPASD SRGQWWAAQE HPSARGDHRG ERGDPRGDQG 610 620 630 640 650 660 THLSALGPAP SLQQPPYQQP LRSGSGPHDC RHSPHGCCPD GHTASLGPQW QGCPGAPCQQ 670 680 690 700 710 720 SRYGCCPDRV SVAEGPHHAG CTKSYGGDST GGMPRSRAVA STVHNTHQPQ AQQNEPSECR 730 740 750 760 770 780 GSQFGCCYDN VATAAGPLGE GCVGQPSHAY PVRCLLPSAH GSCADWAARW YFVASVGQCN 790 800 810 820 830 840 RFWYGGCHGN ANNFASEQEC MSSCQGSLHG PRRPQPGASG RSTHTDGGGS SPAGEQEPSQ 850 860 870 880 890 900 HRTGAAVQRK PWPSGGLWRQ DQQPGPGEAP HTQAFGEWPW GQELGSRAPG LGGDAGSPAP 910 920 930 940 950 960 PFHSSSYRIS LAGVEPSLVQ AALGQLVRLS CSDDTAPESQ AAWQKDGQPI SSDRHRLQFD 970 980 990 1000 1010 1020 GSLIIHPLQA EDAGTYSCGS TRPGRDSQKI QLRIIGGDMA VLSEAELSRF PQPRDPAQDF 1030 1040 1050 1060 1070 1080 GQAGAAGPLG AIPSSHPQPA NRLRLDQNQP RVVDASPGQR IRMTCRAEGF PPPAIEWQRD 1090 1100 1110 1120 1130 1140 GQPVSSPRHQ LQPDGSLVIS RVAVEDGGFY TCVAFNGQDR DQRWVQLRVL GELTISGLPP 1150 1160 1170 1180 1190 1200 TVTVPEGDTA RLLCVVAGES VNIRWSRNGL PVQADGHRVH QSPDGTLLIY NLRARDEGSY 1210 1220 1230 1240 1250 1260 TCSAYQGSQA VSRSTEVKVV SPAPTAQPRD PGRDCVDQPE LANCDLILQA QLCGNEYYSS 1270 FCCASCSRFQ PHAQPIWQ
	Isoform 2 [UniParc]. Checksum: 1979A1F2428DE816	FASTA	477	51,082
	10 20 30 40 50 60 MGPVVPSLGL LEGAPTRMVA AAVLQASRNP ASTGQGPRCR ESPGLLVVSG GKTNSLGQGR 70 80 90 100 110 120 PPTPRPLENG HGGRSLGPGP LDWVEMPDHQ RHPSTAPPTD LTSHLSRISL AGVEPSLVQA 130 140 150 160 170 180 ALGQLVRLSC SDDTAPESQA AWQKDGQPIS SDRHRLQFDG SLIIHPLQAE DAGTYSCGST 190 200 210 220 230 240 RPGRDSQKIQ LRIIGGDMAV LSEAELSRFP QPRDPAQDFG QAGAAGPLGA IPSSHPQPAN 250 260 270 280 290 300 RLRLDQNQPR VVDASPGQRI RMTCRAEGFP PPAIEWQRDG QPVSSPRHQL QPDGSLVISR 310 320 330 340 350 360 VAVEDGGFYT CVAFNGQDRD QRWVQLRVLG ELTISGLPPT VTVPEGDTAR LLCVVAGESV 370 380 390 400 410 420 NIRWSRNGLP VQADGHRVHQ SPDGTLLIYN LRARDEGSYT CSAYQGSQAV SRSTEVKVVS 430 440 450 460 470 PAPTAQPRDP GRDCVDQPEL ANCDLILQAQ LCGNEYYSSF CCASCSRFQP HAQPIWQ
	Isoform 5 [UniParc]. Checksum: 3D334E4C30CDE94F	FASTA	1,262	136,073
	10 20 30 40 50 60 MRLLLLVPLL LAPAPGSSAP KVRRQSDTWG PWSQWSPCSR TCGGGVSFRE RPCYSQRRDG 70 80 90 100 110 120 GSSCVGPARS HRSCRTESCP DGARDFRAEQ CAEFDGAEFQ GRRYRWLPYY SAPNKCELNC 130 140 150 160 170 180 IPKGENFYYK HREAVVDGTP CEPGKRDVCV DGSCRVVGCD HELDSSKQED KCLRCGGDGT 190 200 210 220 230 240 TCYPVAGTFD ANDLSRGYNQ ILIVPMGATS ILIDEAAASR NFLAVKNVRG EYYLNGHWTI 250 260 270 280 290 300 EAARALPAAS TILHYERGAE GDLAPERLHA RGPTSEPLVI ELISQEPNPG VHYEYHLPLR 310 320 330 340 350 360 RPSPGFSWSH GSWSDCSAEC GGGHQSRLVF CTIDHEAYPD HMCQRQPRPA DRRSCNLHPC 370 380 390 400 410 420 PETKRWKAGP WAPCSASCGG GSQSRSVYCI SSDGAGIQEA VEEAECAGLP GKPPAIQACN 430 440 450 460 470 480 LQRCAAWSPE PWGECSVSCG VGVRKRSVTC RGERGSLLHT AACSLEDRPP LTEPCVHEDC 490 500 510 520 530 540 PLLSDQAWHV GTWGLCSKSC SSGTRRRQVI CAIGPPSHCG SLQHSKPVDV EPCNTQPCHL 550 560 570 580 590 600 PQEVPSMQDV HTPASNPWMP LGPQESPASD SRGQWWAAQE HPSARGDHRG ERGDPRGDQG 610 620 630 640 650 660 THLSALGPAP SLQQPPYQQP LRSGSGPHDC RHSPHGCCPD GHTASLGPQW QGCPGAPCQQ 670 680 690 700 710 720 SRYGCCPDRV SVAEGPHHAG CTKSYGGDST GGMPRSRAVA STVHNTHQPQ AQQNEPSECR 730 740 750 760 770 780 GSQFGCCYDN VATAAGPLGE GCVGQPSHDW AARWYFVASV GQCNRFWYGG CHGNANNFAS 790 800 810 820 830 840 EQECMSSCQG SLHGPRRPQP GASGRSTHTD GGGSSPAGEQ EPSQHRTGAA VQRKPWPSGG 850 860 870 880 890 900 LWRQDQQPGP GEAPHTQAFG EWPWGQELGS RAPGLGGDAG SPAPPFHSSS YRISLAGVEP 910 920 930 940 950 960 SLVQAALGQL VRLSCSDDTA PESQAAWQKD GQPISSDRHR LQFDGSLIIH PLQAEDAGTY 970 980 990 1000 1010 1020 SCGSTRPGRD SQKIQLRIIG GDMAVLSEAE LSRFPQPRDP AQDFGQAGAA GPLGAIPSSH 1030 1040 1050 1060 1070 1080 PQPANRLRLD QNQPRVVDAS PGQRIRMTCR AEGFPPPAIE WQRDGQPVSS PRHQLQPDGS 1090 1100 1110 1120 1130 1140 LVISRVAVED GGFYTCVAFN GQDRDQRWVQ LRVLGELTIS GLPPTVTVPE GDTARLLCVV 1150 1160 1170 1180 1190 1200 AGESVNIRWS RNGLPVQADG HRVHQSPDGT LLIYNLRARD EGSYTCSAYQ GSQAVSRSTE 1210 1220 1230 1240 1250 1260 VKVVSPAPTA QPRDPGRDCV DQPELANCDL ILQAQLCGNE YYSSFCCASC SRFQPHAQPI WQ
	Isoform 6 [UniParc]. Checksum: 149C41975845C4E9	FASTA	1,251	134,840
	10 20 30 40 50 60 MRLLLLVPLL LAPAPGSSAP KVRRQSDTWG PWSQWSPCSR TCGGGVSFRE RPCYSQRRDG 70 80 90 100 110 120 GSSCVGPARS HRSCRTESCP DGARDFRAEQ CAEFDGAEFQ GRRYRWLPYY SAPNKCELNC 130 140 150 160 170 180 IPKGENFYYK HREAVVDGTP CEPGKRDVCV DGSCRVVGCD HELDSSKQED KCLRCGGDGT 190 200 210 220 230 240 TCYPVAGTFD ANDLSRAVKN VRGEYYLNGH WTIEAARALP AASTILHYER GAEGDLAPER 250 260 270 280 290 300 LHARGPTSEP LVIELISQEP NPGVHYEYHL PLRRPSPGFS WSHGSWSDCS AECGGGHQSR 310 320 330 340 350 360 LVFCTIDHEA YPDHMCQRQP RPADRRSCNL HPCPETKRWK AGPWAPCSAS CGGGSQSRSV 370 380 390 400 410 420 YCISSDGAGI QEAVEEAECA GLPGKPPAIQ ACNLQRCAAW SPEPWGECSV SCGVGVRKRS 430 440 450 460 470 480 VTCRGERGSL LHTAACSLED RPPLTEPCVH EDCPLLSDQA WHVGTWGLCS KSCSSGTRRR 490 500 510 520 530 540 QVICAIGPPS HCGSLQHSKP VDVEPCNTQP CHLPQEVPSM QDVHTPASNP WMPLGPQESP 550 560 570 580 590 600 ASDSRGQWWA AQEHPSARGD HRGERGDPRG DQGTHLSALG PAPSLQQPPY QQPLRSGSGP 610 620 630 640 650 660 HDCRHSPHGC CPDGHTASLG PQWQGCPGAP CQQSRYGCCP DRVSVAEGPH HAGCTKSYGG 670 680 690 700 710 720 DSTGGMPRSR AVASTVHNTH QPQAQQNEPS ECRGSQFGCC YDNVATAAGP LGEGCVGQPS 730 740 750 760 770 780 HAYPVRCLLP SAHGSCADWA ARWYFVASVG QCNRFWYGGC HGNANNFASE QECMSSCQGS 790 800 810 820 830 840 LHGPRRPQPG ASGRSTHTDG GGSSPAGEQE PSQHRTGAAV QRKPWPSGGL WRQDQQPGPG 850 860 870 880 890 900 EAPHTQAFGE WPWGQELGSR APGLGGDAGS PAPPFHSSSY RISLAGVEPS LVQAALGQLV 910 920 930 940 950 960 RLSCSDDTAP ESQAAWQKDG QPISSDRHRL QFDGSLIIHP LQAEDAGTYS CGSTRPGRDS 970 980 990 1000 1010 1020 QKIQLRIIGG DMAVLSEAEL SRFPQPRDPA QDFGQAGAAG PLGAIPSSHP QPANRLRLDQ 1030 1040 1050 1060 1070 1080 NQPRVVDASP GQRIRMTCRA EGFPPPAIEW QRDGQPVSSP RHQLQPDGSL VISRVAVEDG 1090 1100 1110 1120 1130 1140 GFYTCVAFNG QDRDQRWVQL RVLGELTISG LPPTVTVPEG DTARLLCVVA GESVNIRWSR 1150 1160 1170 1180 1190 1200 NGLPVQADGH RVHQSPDGTL LIYNLRARDE GSYTCSAYQG SQAVSRSTEV KVVSPAPTAQ 1210 1220 1230 1240 1250 PRDPGRDCVD QPELANCDLI LQAQLCGNEY YSSFCCASCS RFQPHAQPIW Q
	Isoform 3 [UniParc]. Checksum: D51144A494C12B3B	FASTA	129	14,368
	10 20 30 40 50 60 MRLLLLVPLL LAPAPGSSAP KVRRQSDTWG PWSQWSPCSR TCGGGVSFRE RPCYSQRRDG 70 80 90 100 110 120 GSSCVGPARS HRSCRTESCP DGARDFRAEQ CAEFDGAEFQ GRRYRWLPYY SAPNKCELNC IPKVLGLQA
	Isoform 4 [UniParc]. Checksum: FB23C426C3F47E83	FASTA	1,109	119,209
	10 20 30 40 50 60 MRLLLLVPLL LAPAPGSSAP KVRRQSDTWG PWSQWSPCSR TCGGGVSFRE RPCYSQRRDG 70 80 90 100 110 120 GSSCVGPARS HRSCRTESCP DGARDFRAEQ CAEFDGAEFQ GRRYRWLPYY SAPNKCELNC 130 140 150 160 170 180 IPKGENFYYK HREAVVDGTP CEPGKRDVCV DGSCRVVGCD HELDSSKQED KCLRCGGDGT 190 200 210 220 230 240 TCYPVAGTFD ANDLSRGYNQ ILIVPMGATS ILIDEAAASR NFLAVKNVRG EYYLNGHWTI 250 260 270 280 290 300 EAARALPAAS TILHYERGAE GDLAPERLHA RGPTSEPLVI ELISQEPNPG VHYEYHLPLR 310 320 330 340 350 360 RPSPGFSWSH GSWSDCSAEC GGGHQSRLVF CTIDHEAYPD HMCQRQPRPA DRRSCNLHPC 370 380 390 400 410 420 PETKRWKAGP WAPCSASCGG GSQSRSVYCI SSDGAGIQEA VEEAECAGLP GKPPAIQACN 430 440 450 460 470 480 LQRCAAWSPE PWGECSVSCG VGVRKRSVTC RGERGSLLHT AACSLEDRPP LTEPCVHEDC 490 500 510 520 530 540 PLLSDQAWHV GTWGLCSKSC SSGTRRRQVI CAIGPPSHCG SLQHSKPVDV EPCNTQPCHL 550 560 570 580 590 600 PQEVPSMQDV HTPASNPWMP LGPQESPASD SRGQWWAAQE HPSARGDHRG ERGDPRGDQG 610 620 630 640 650 660 THLSALGPAP SLQQPPYQQP LRSGSGPHDC RHSPHGCCPD GHTASLGPQW QGCPGAPCQQ 670 680 690 700 710 720 SRYGCCPDRV SVAEGPHHAG CTKSYGGDST GGMPRSRAVA STVHNTHQPQ AQQNEPSECR 730 740 750 760 770 780 GSQFGCCYDN VATAAGPLGE GCVGQPSHAY PVRCLLPSAH GSCADWAARW YFVASVGQCN 790 800 810 820 830 840 RFWYGGCHGN ANNFASEQEC MSSCQGSLHG PRRPQPGASG RSTHTDGGGS SPAGEQEPSQ 850 860 870 880 890 900 HRTGAAVQRK PWPSGGLWRQ DQQPGPGEAP HTQAFGEWPW GQELGSRAPG LGGDAGSPAP 910 920 930 940 950 960 PFHSSSYRIS LAGVEPSLVQ AALGQLVRLS CSDDTAPESQ AAWQKDGQPI SSDRHRLQFD 970 980 990 1000 1010 1020 GSLIIHPLQA EDAGTYSCGS TRPGRDSQKI QLRIIGGDMA VLSEAELSRF PQPRDPAQDF 1030 1040 1050 1060 1070 1080 GQAGAAGPLG AIPSSHPQPA NRLRLDQNQP RVVDASPGQR IRMTCRAEGF PPPAIEWQRD 1090 1100 GQPVSSPSTH RPAQGPWQGL RRPARAGQL

References

[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT MET-1201.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 800-1217 (ISOFORM 4). Tissue: Amygdala, Cerebellum and Synovial cell.
[3]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-896.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Ovary.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 81-302 (ISOFORM 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-1278 (ISOFORM 1). Tissue: Liver and Testis.
[6]	"The nucleotide sequence of a long cDNA clone isolated from human spleen." Jikuya H., Takano J., Kikuno R., Nagase T., Ohara O. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 620-1278 (ISOFORM 1). Tissue: Spleen.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358330 mRNA. Translation: AAQ88696.1. AK125658 mRNA. Translation: BAC86235.1. Different initiation. AK294560 mRNA. Translation: BAG57757.1. Different initiation. AK293773 mRNA. Translation: BAG57189.1. Sequence problems. AC004846 Genomic DNA. No translation available. AF109907 Genomic DNA. Translation: AAC97963.1. Sequence problems. BC042057 mRNA. Translation: AAH42057.1. AL110280 mRNA. Translation: CAH56406.1. Sequence problems. BX470414 mRNA. No translation available. BX537757 mRNA. Translation: CAD97826.1. AK131073 mRNA. Translation: BAC85123.1.
IPI	IPI00445654. IPI00795260. IPI00872077. IPI00887374. IPI00937971. IPI00938081.
RefSeq	NP_775733.3. NM_173462.3.
UniGene	Hs.509909.
3D structure databases
ProteinModelPortal	O95428.
ModBase	Search...
Protein family/group databases
MEROPS	I43.001.
PTM databases
PhosphoSite	O95428.
Proteomic databases
PaxDb	O95428.
PRIDE	O95428.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340738; ENSP00000345395; ENSG00000100767. ENST00000381166; ENSP00000370558; ENSG00000100767. ENST00000427855; ENSP00000403403; ENSG00000100767. ENST00000554301; ENSP00000451803; ENSG00000100767. ENST00000555445; ENSP00000451729; ENSG00000100767.
GeneID	89932.
KEGG	hsa:89932.
UCSC	uc001xnw.4. human. uc010arm.3. human. uc010ttx.2. human. uc010tty.2. human.
Organism-specific databases
CTD	89932.
GeneCards	GC14P073704.
H-InvDB	HIX0019543. HIX0037927.
HGNC	HGNC:19262. PAPLN.
HPA	HPA048682.
neXtProt	NX_O95428.
PharmGKB	PA134914395.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG242665.
HOVERGEN	HBG108281.
OMA	SVNIRWS.
OrthoDB	EOG4V6ZGD.
Gene expression databases
ArrayExpress	O95428.
Bgee	O95428.
CleanEx	HS_PAPLN.
Genevestigator	O95428.
Family and domain databases
Gene3D	2.60.40.10. 3 hits. 4.10.410.10. 1 hit.
InterPro	IPR010294. ADAM_spacer1. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003598. Ig_sub2. IPR013273. Peptidase_M12B_ADAM-TS. IPR010909. PLAC. IPR002223. Prot_inh_Kunz-m. IPR020901. Prtase_inh_Kunz-CS. IPR000884. Thrombospondin_1_rpt. [Graphical view]
Pfam	PF05986. ADAM_spacer1. 1 hit. PF07679. I-set. 3 hits. PF00014. Kunitz_BPTI. 1 hit. PF08686. PLAC. 1 hit. PF00090. TSP_1. 5 hits. [Graphical view]
PRINTS	PR01857. ADAMTSFAMILY. PR00759. BASICPTASE.
SMART	SM00408. IGc2. 3 hits. SM00131. KU. 1 hit. SM00209. TSP1. 5 hits. [Graphical view]
SUPFAM	SSF57362. Prot_inh_Kunz-m. 1 hit. SSF82895. TSP1. 5 hits.
PROSITE	PS00280. BPTI_KUNITZ_1. 1 hit. PS50279. BPTI_KUNITZ_2. 1 hit. PS50835. IG_LIKE. 3 hits. PS50900. PLAC. 1 hit. PS50092. TSP1. 5 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PAPLN. human.
GenomeRNAi	89932.
NextBio	76441.

Entry information

Entry name

PPN_HUMAN

Accession

Primary (citable) accession number: O95428
Secondary accession number(s): B4DES8 , B4DGE6, Q659F2, Q6UXJ4, Q6ZNM1, Q6ZUJ0, Q7Z681, Q8IVU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	July 7, 2009
Last modified:	May 29, 2013
This is version 95 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.