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O95428

- PPN_HUMAN

UniProt

O95428 - PPN_HUMAN

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Protein

Papilin

Gene

PAPLN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro
  2. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI02.972.

Names & Taxonomyi

Protein namesi
Recommended name:
Papilin
Gene namesi
Name:PAPLN
ORF Names:UNQ2420/PRO4977
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:19262. PAPLN.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. basement membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134914395.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 12781260PapilinPRO_0000324550Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi38 ↔ 74By similarity
Disulfide bondi42 ↔ 79By similarity
Disulfide bondi53 ↔ 64By similarity
Disulfide bondi316 ↔ 355By similarity
Disulfide bondi320 ↔ 360By similarity
Disulfide bondi331 ↔ 343By similarity
Disulfide bondi754 ↔ 804By similarity
Disulfide bondi763 ↔ 787By similarity
Disulfide bondi779 ↔ 800By similarity
Disulfide bondi931 ↔ 978By similarity
Disulfide bondi1065 ↔ 1112By similarity
Disulfide bondi1154 ↔ 1202By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO95428.
PRIDEiO95428.

PTM databases

PhosphoSiteiO95428.

Expressioni

Gene expression databases

BgeeiO95428.
CleanExiHS_PAPLN.
ExpressionAtlasiO95428. baseline and differential.
GenevestigatoriO95428.

Organism-specific databases

HPAiHPA048682.

Interactioni

Protein-protein interaction databases

IntActiO95428. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO95428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 8055TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini304 – 36158TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini362 – 42160TSP type-1 3PROSITE-ProRule annotationAdd
BLAST
Domaini423 – 48159TSP type-1 4PROSITE-ProRule annotationAdd
BLAST
Domaini484 – 53956TSP type-1 5PROSITE-ProRule annotationAdd
BLAST
Domaini754 – 80451BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd
BLAST
Domaini900 – 99596Ig-like C2-type 1Add
BLAST
Domaini1033 – 112896Ig-like C2-type 2Add
BLAST
Domaini1133 – 121886Ig-like C2-type 3Add
BLAST
Domaini1231 – 127040PLACPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the papilin family.Curated
Contains 1 BPTI/Kunitz inhibitor domain.PROSITE-ProRule annotation
Contains 1 PLAC domain.PROSITE-ProRule annotation
Contains 5 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG242665.
GeneTreeiENSGT00760000118885.
HOVERGENiHBG108281.
InParanoidiO95428.
OMAiSVNIRWS.
OrthoDBiEOG7W419Z.
PhylomeDBiO95428.
TreeFamiTF316874.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
4.10.410.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF07679. I-set. 3 hits.
PF00014. Kunitz_BPTI. 1 hit.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 5 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
PR00759. BASICPTASE.
SMARTiSM00408. IGc2. 3 hits.
SM00131. KU. 1 hit.
SM00209. TSP1. 5 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 1 hit.
SSF82895. SSF82895. 5 hits.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
PS50835. IG_LIKE. 3 hits.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 5 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95428-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLLLLVPLL LAPAPGSSAP KVRRQSDTWG PWSQWSPCSR TCGGGVSFRE
60 70 80 90 100
RPCYSQRRDG GSSCVGPARS HRSCRTESCP DGARDFRAEQ CAEFDGAEFQ
110 120 130 140 150
GRRYRWLPYY SAPNKCELNC IPKGENFYYK HREAVVDGTP CEPGKRDVCV
160 170 180 190 200
DGSCRVVGCD HELDSSKQED KCLRCGGDGT TCYPVAGTFD ANDLSRGYNQ
210 220 230 240 250
ILIVPMGATS ILIDEAAASR NFLAVKNVRG EYYLNGHWTI EAARALPAAS
260 270 280 290 300
TILHYERGAE GDLAPERLHA RGPTSEPLVI ELISQEPNPG VHYEYHLPLR
310 320 330 340 350
RPSPGFSWSH GSWSDCSAEC GGGHQSRLVF CTIDHEAYPD HMCQRQPRPA
360 370 380 390 400
DRRSCNLHPC PETKRWKAGP WAPCSASCGG GSQSRSVYCI SSDGAGIQEA
410 420 430 440 450
VEEAECAGLP GKPPAIQACN LQRCAAWSPE PWGECSVSCG VGVRKRSVTC
460 470 480 490 500
RGERGSLLHT AACSLEDRPP LTEPCVHEDC PLLSDQAWHV GTWGLCSKSC
510 520 530 540 550
SSGTRRRQVI CAIGPPSHCG SLQHSKPVDV EPCNTQPCHL PQEVPSMQDV
560 570 580 590 600
HTPASNPWMP LGPQESPASD SRGQWWAAQE HPSARGDHRG ERGDPRGDQG
610 620 630 640 650
THLSALGPAP SLQQPPYQQP LRSGSGPHDC RHSPHGCCPD GHTASLGPQW
660 670 680 690 700
QGCPGAPCQQ SRYGCCPDRV SVAEGPHHAG CTKSYGGDST GGMPRSRAVA
710 720 730 740 750
STVHNTHQPQ AQQNEPSECR GSQFGCCYDN VATAAGPLGE GCVGQPSHAY
760 770 780 790 800
PVRCLLPSAH GSCADWAARW YFVASVGQCN RFWYGGCHGN ANNFASEQEC
810 820 830 840 850
MSSCQGSLHG PRRPQPGASG RSTHTDGGGS SPAGEQEPSQ HRTGAAVQRK
860 870 880 890 900
PWPSGGLWRQ DQQPGPGEAP HTQAFGEWPW GQELGSRAPG LGGDAGSPAP
910 920 930 940 950
PFHSSSYRIS LAGVEPSLVQ AALGQLVRLS CSDDTAPESQ AAWQKDGQPI
960 970 980 990 1000
SSDRHRLQFD GSLIIHPLQA EDAGTYSCGS TRPGRDSQKI QLRIIGGDMA
1010 1020 1030 1040 1050
VLSEAELSRF PQPRDPAQDF GQAGAAGPLG AIPSSHPQPA NRLRLDQNQP
1060 1070 1080 1090 1100
RVVDASPGQR IRMTCRAEGF PPPAIEWQRD GQPVSSPRHQ LQPDGSLVIS
1110 1120 1130 1140 1150
RVAVEDGGFY TCVAFNGQDR DQRWVQLRVL GELTISGLPP TVTVPEGDTA
1160 1170 1180 1190 1200
RLLCVVAGES VNIRWSRNGL PVQADGHRVH QSPDGTLLIY NLRARDEGSY
1210 1220 1230 1240 1250
TCSAYQGSQA VSRSTEVKVV SPAPTAQPRD PGRDCVDQPE LANCDLILQA
1260 1270
QLCGNEYYSS FCCASCSRFQ PHAQPIWQ
Length:1,278
Mass (Da):137,700
Last modified:July 7, 2009 - v4
Checksum:iA8DED3CADB0D70C1
GO
Isoform 2 (identifier: O95428-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-801: Missing.
     802-907: SSCQGSLHGP...PAPPFHSSSY → MGPVVPSLGL...PPTDLTSHLS

Note: No experimental confirmation available.

Show »
Length:477
Mass (Da):51,082
Checksum:i1979A1F2428DE816
GO
Isoform 5 (identifier: O95428-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     749-764: Missing.

Show »
Length:1,262
Mass (Da):136,073
Checksum:i3D334E4C30CDE94F
GO
Isoform 6 (identifier: O95428-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-223: Missing.

Note: No experimental confirmation available.

Show »
Length:1,251
Mass (Da):134,840
Checksum:i149C41975845C4E9
GO
Isoform 3 (identifier: O95428-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-129: GENFYY → VLGLQA
     130-1278: Missing.

Note: No experimental confirmation available.

Show »
Length:129
Mass (Da):14,368
Checksum:iD51144A494C12B3B
GO
Isoform 4 (identifier: O95428-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1088-1109: RHQLQPDGSLVISRVAVEDGGF → STHRPAQGPWQGLRRPARAGQL
     1110-1278: Missing.

Note: No experimental confirmation available.

Show »
Length:1,109
Mass (Da):119,209
Checksum:iFB23C426C3F47E83
GO

Sequence cautioni

The sequence CAH56406.1 differs from that shown. Reason: Partially unspliced mRNA.
The sequence BAC86235.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAG57189.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAG57757.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAG57189.1 differs from that shown. Reason: Erroneous termination at position 1216. Translated as Glu.
The sequence AAC97963.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti326 – 3261S → P in BAG57757. (PubMed:14702039)Curated
Sequence conflicti693 – 6931M → R in BAG57757. (PubMed:14702039)Curated
Sequence conflicti693 – 6931M → R in CAD97826. (PubMed:17974005)Curated
Sequence conflicti693 – 6931M → R in BAC85123. 1 PublicationCurated
Sequence conflicti1162 – 11621N → D in BAG57189. (PubMed:14702039)Curated
Sequence conflicti1229 – 12291R → K in CAD97826. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331S → G.
Corresponds to variant rs2280792 [ dbSNP | Ensembl ].
VAR_039815
Natural varianti191 – 1911A → T.
Corresponds to variant rs741842 [ dbSNP | Ensembl ].
VAR_039816
Natural varianti356 – 3561N → H.
Corresponds to variant rs17126331 [ dbSNP | Ensembl ].
VAR_039817
Natural varianti443 – 4431V → I.
Corresponds to variant rs17126352 [ dbSNP | Ensembl ].
VAR_039818
Natural varianti461 – 4611A → V.
Corresponds to variant rs17126354 [ dbSNP | Ensembl ].
VAR_039819
Natural varianti628 – 6281H → R.
Corresponds to variant rs17182244 [ dbSNP | Ensembl ].
VAR_039820
Natural varianti723 – 7231Q → H.
Corresponds to variant rs2242616 [ dbSNP | Ensembl ].
VAR_039821
Natural varianti896 – 8961G → R.1 Publication
Corresponds to variant rs177386 [ dbSNP | Ensembl ].
VAR_039822
Natural varianti1192 – 11921L → V.
Corresponds to variant rs2107731 [ dbSNP | Ensembl ].
VAR_039823
Natural varianti1201 – 12011T → M.1 Publication
Corresponds to variant rs4903104 [ dbSNP | Ensembl ].
VAR_039824
Natural varianti1260 – 12601S → T.
Corresponds to variant rs11626824 [ dbSNP | Ensembl ].
VAR_039825

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 801801Missing in isoform 2. 1 PublicationVSP_032269Add
BLAST
Alternative sequencei124 – 1296GENFYY → VLGLQA in isoform 3. 1 PublicationVSP_032270
Alternative sequencei130 – 12781149Missing in isoform 3. 1 PublicationVSP_032271Add
BLAST
Alternative sequencei197 – 22327Missing in isoform 6. 1 PublicationVSP_037595Add
BLAST
Alternative sequencei749 – 76416Missing in isoform 5. 1 PublicationVSP_037596Add
BLAST
Alternative sequencei802 – 907106SSCQG…HSSSY → MGPVVPSLGLLEGAPTRMVA AAVLQASRNPASTGQGPRCR ESPGLLVVSGGKTNSLGQGR PPTPRPLENGHGGRSLGPGP LDWVEMPDHQRHPSTAPPTD LTSHLS in isoform 2. 1 PublicationVSP_032272Add
BLAST
Alternative sequencei1088 – 110922RHQLQ…EDGGF → STHRPAQGPWQGLRRPARAG QL in isoform 4. 1 PublicationVSP_032273Add
BLAST
Alternative sequencei1110 – 1278169Missing in isoform 4. 1 PublicationVSP_032274Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358330 mRNA. Translation: AAQ88696.1.
AK125658 mRNA. Translation: BAC86235.1. Different initiation.
AK294560 mRNA. Translation: BAG57757.1. Different initiation.
AK293773 mRNA. Translation: BAG57189.1. Sequence problems.
AC004846 Genomic DNA. No translation available.
AF109907 Genomic DNA. Translation: AAC97963.1. Sequence problems.
BC042057 mRNA. Translation: AAH42057.1.
AL110280 mRNA. Translation: CAH56406.1. Sequence problems.
BX470414 mRNA. No translation available.
BX537757 mRNA. Translation: CAD97826.1.
AK131073 mRNA. Translation: BAC85123.1.
CCDSiCCDS32114.1. [O95428-6]
RefSeqiNP_775733.3. NM_173462.3. [O95428-6]
UniGeneiHs.509909.

Genome annotation databases

EnsembliENST00000340738; ENSP00000345395; ENSG00000100767. [O95428-6]
ENST00000554301; ENSP00000451803; ENSG00000100767. [O95428-1]
ENST00000555445; ENSP00000451729; ENSG00000100767. [O95428-5]
GeneIDi89932.
KEGGihsa:89932.
UCSCiuc001xnw.4. human. [O95428-6]
uc010arm.3. human. [O95428-2]
uc010ttx.2. human. [O95428-1]
uc010tty.2. human. [O95428-5]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358330 mRNA. Translation: AAQ88696.1 .
AK125658 mRNA. Translation: BAC86235.1 . Different initiation.
AK294560 mRNA. Translation: BAG57757.1 . Different initiation.
AK293773 mRNA. Translation: BAG57189.1 . Sequence problems.
AC004846 Genomic DNA. No translation available.
AF109907 Genomic DNA. Translation: AAC97963.1 . Sequence problems.
BC042057 mRNA. Translation: AAH42057.1 .
AL110280 mRNA. Translation: CAH56406.1 . Sequence problems.
BX470414 mRNA. No translation available.
BX537757 mRNA. Translation: CAD97826.1 .
AK131073 mRNA. Translation: BAC85123.1 .
CCDSi CCDS32114.1. [O95428-6 ]
RefSeqi NP_775733.3. NM_173462.3. [O95428-6 ]
UniGenei Hs.509909.

3D structure databases

ProteinModelPortali O95428.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O95428. 1 interaction.

Protein family/group databases

MEROPSi I02.972.

PTM databases

PhosphoSitei O95428.

Proteomic databases

PaxDbi O95428.
PRIDEi O95428.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340738 ; ENSP00000345395 ; ENSG00000100767 . [O95428-6 ]
ENST00000554301 ; ENSP00000451803 ; ENSG00000100767 . [O95428-1 ]
ENST00000555445 ; ENSP00000451729 ; ENSG00000100767 . [O95428-5 ]
GeneIDi 89932.
KEGGi hsa:89932.
UCSCi uc001xnw.4. human. [O95428-6 ]
uc010arm.3. human. [O95428-2 ]
uc010ttx.2. human. [O95428-1 ]
uc010tty.2. human. [O95428-5 ]

Organism-specific databases

CTDi 89932.
GeneCardsi GC14P073704.
H-InvDB HIX0019543.
HIX0037927.
HGNCi HGNC:19262. PAPLN.
HPAi HPA048682.
neXtProti NX_O95428.
PharmGKBi PA134914395.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG242665.
GeneTreei ENSGT00760000118885.
HOVERGENi HBG108281.
InParanoidi O95428.
OMAi SVNIRWS.
OrthoDBi EOG7W419Z.
PhylomeDBi O95428.
TreeFami TF316874.

Miscellaneous databases

ChiTaRSi PAPLN. human.
GeneWikii PAPLN.
GenomeRNAii 89932.
NextBioi 76441.
PROi O95428.

Gene expression databases

Bgeei O95428.
CleanExi HS_PAPLN.
ExpressionAtlasi O95428. baseline and differential.
Genevestigatori O95428.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
4.10.410.10. 1 hit.
InterProi IPR010294. ADAM_spacer1.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
IPR000884. Thrombospondin_1_rpt.
[Graphical view ]
Pfami PF05986. ADAM_spacer1. 1 hit.
PF07679. I-set. 3 hits.
PF00014. Kunitz_BPTI. 1 hit.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 5 hits.
[Graphical view ]
PRINTSi PR01857. ADAMTSFAMILY.
PR00759. BASICPTASE.
SMARTi SM00408. IGc2. 3 hits.
SM00131. KU. 1 hit.
SM00209. TSP1. 5 hits.
[Graphical view ]
SUPFAMi SSF57362. SSF57362. 1 hit.
SSF82895. SSF82895. 5 hits.
PROSITEi PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
PS50835. IG_LIKE. 3 hits.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT MET-1201.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 800-1217 (ISOFORM 4).
    Tissue: Amygdala, Cerebellum and Synovial cell.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-896.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Ovary.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 81-302 (ISOFORM 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-1278 (ISOFORM 1).
    Tissue: Liver and Testis.
  6. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Kikuno R., Nagase T., Ohara O.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 620-1278 (ISOFORM 1).
    Tissue: Spleen.

Entry informationi

Entry nameiPPN_HUMAN
AccessioniPrimary (citable) accession number: O95428
Secondary accession number(s): B4DES8
, B4DGE6, Q659F2, Q6UXJ4, Q6ZNM1, Q6ZUJ0, Q7Z681, Q8IVU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 7, 2009
Last modified: October 29, 2014
This is version 106 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3