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Protein

Supervillin

Gene

SVIL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Isoform 1: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420).2 Publications
Isoform 2: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity).By similarity

GO - Molecular functioni

  • actin filament binding Source: UniProtKB

GO - Biological processi

  • cytoskeleton organization Source: InterPro
  • positive regulation of cytokinesis Source: UniProtKB
  • skeletal muscle tissue development Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium

Enzyme and pathway databases

BioCyciZFISH:G66-30954-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Supervillin1 Publication
Alternative name(s):
Archvillin1 Publication
p205/p2502 Publications
Gene namesi
Name:SVIL1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:11480. SVIL.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: UniProtKB
  • cleavage furrow Source: UniProtKB
  • costamere Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • invadopodium Source: UniProtKB-SubCell
  • microtubule minus-end Source: UniProtKB
  • midbody Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • podosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2176L → K: Strongly increased affinity for F-actin. 1 Publication1

Organism-specific databases

DisGeNETi6840.
OpenTargetsiENSG00000197321.
PharmGKBiPA36265.

Polymorphism and mutation databases

BioMutaiSVIL.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002187401 – 2214SupervillinAdd BLAST2214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50PhosphoserineCombined sources1
Modified residuei221PhosphoserineCombined sources1
Modified residuei238PhosphoserineBy similarity1
Modified residuei240PhosphothreonineCombined sources1
Modified residuei245PhosphoserineCombined sources1
Modified residuei253PhosphoserineCombined sources1
Modified residuei259PhosphoserineBy similarity1
Modified residuei270PhosphoserineCombined sources1
Modified residuei319PhosphoserineBy similarity1
Modified residuei673PhosphoserineBy similarity1
Modified residuei707PhosphoserineCombined sources1
Modified residuei769PhosphoserineCombined sources1
Modified residuei850PhosphotyrosineBy similarity1
Modified residuei852PhosphothreonineCombined sources1
Modified residuei914PhosphoserineCombined sources1
Modified residuei920PhosphoserineCombined sources1
Modified residuei924PhosphoserineCombined sources1
Modified residuei968PhosphoserineCombined sources1
Modified residuei1000PhosphoserineBy similarity1
Modified residuei1052PhosphoserineBy similarity1
Modified residuei1111PhosphothreonineCombined sources1
Modified residuei1120PhosphoserineCombined sources1
Modified residuei1203Omega-N-methylarginineCombined sources1
Modified residuei1225PhosphoserineCombined sources1
Modified residuei1230PhosphothreonineCombined sources1
Modified residuei1234PhosphoserineBy similarity1
Modified residuei1322PhosphoserineCombined sources1
Modified residuei1405PhosphoserineBy similarity1
Isoform 2 (identifier: O95425-2)
Modified residuei261PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1
Isoform SV3 (identifier: O95425-3)
Modified residuei261PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiO95425.
MaxQBiO95425.
PaxDbiO95425.
PeptideAtlasiO95425.
PRIDEiO95425.

PTM databases

iPTMnetiO95425.
PhosphoSitePlusiO95425.

Expressioni

Tissue specificityi

Expressed in many tissues. Most abundant in muscle, bone marrow, thyroid gland and salivary gland. Isoform 1 (archvillin) is muscle specific.1 Publication

Gene expression databases

BgeeiENSG00000197321.
CleanExiHS_SVIL.
ExpressionAtlasiO95425. baseline and differential.
GenevisibleiO95425. HS.

Organism-specific databases

HPAiCAB010878.
HPA020095.
HPA020138.

Interactioni

Subunit structurei

Associates with F-actin (By similarity). Interacts with NEB (By similarity). Interacts with MYH9 (By similarity). Interacts with MYLK (By similarity). Isoform 2: Interacts with TRIP6 (By similarity). Isoform 2: Interacts with DYNLT1 (By similarity). Isoform 2: Interacts with KIF14; at midbody during cytokinesis (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NEBP209294EBI-487145,EBI-1049657

GO - Molecular functioni

  • actin filament binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112707. 123 interactors.
IntActiO95425. 61 interactors.
MINTiMINT-1369291.
STRINGi9606.ENSP00000348128.

Structurei

Secondary structure

12214
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2159 – 2162Combined sources4
Beta strandi2169 – 2172Combined sources4
Helixi2177 – 2179Combined sources3
Helixi2182 – 2188Combined sources7
Beta strandi2189 – 2191Combined sources3
Helixi2193 – 2196Combined sources4
Helixi2201 – 2211Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K6MNMR-S2149-2214[»]
2K6NNMR-A2149-2214[»]
ProteinModelPortaliO95425.
SMRiO95425.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95425.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1441 – 1540Gelsolin-like 1Add BLAST100
Repeati1560 – 1682Gelsolin-like 2Add BLAST123
Repeati1752 – 1862Gelsolin-like 3Add BLAST111
Repeati1881 – 1982Gelsolin-like 4Add BLAST102
Repeati2015 – 2122Gelsolin-like 5Add BLAST108
Domaini2151 – 2214HPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 174Interaction with MYLKBy similarityAdd BLAST174
Regioni1419 – 1687Interaction with NEB1 PublicationAdd BLAST269

Domaini

As opposed to other villin-type headpiece domains, supervillin HP (SVHP) doesn't bind F-actin due to the absence of a conformationally flexible region (V-loop).1 Publication

Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated
Contains 5 gelsolin-like repeats.Curated
Contains 1 HP (headpiece) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0445. Eukaryota.
ENOG410XPWY. LUCA.
GeneTreeiENSGT00760000119111.
HOVERGENiHBG052980.
InParanoidiO95425.
KOiK10369.
OMAiRSHTQPI.
OrthoDBiEOG091G00HK.
PhylomeDBiO95425.
TreeFamiTF316081.

Family and domain databases

Gene3Di1.10.950.10. 1 hit.
3.40.20.10. 5 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR015628. SV/p205.
IPR007122. Villin/Gelsolin.
IPR003128. Villin_headpiece.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 2 hits.
PTHR11977:SF45. PTHR11977:SF45. 2 hits.
PfamiPF00626. Gelsolin. 1 hit.
PF02209. VHP. 1 hit.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 4 hits.
SM00153. VHP. 1 hit.
[Graphical view]
SUPFAMiSSF47050. SSF47050. 1 hit.
PROSITEiPS51089. HP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95425-1) [UniParc]FASTAAdd to basket
Also known as: Archvillin1 Publication, p2501 Publication, SV2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRKERIARR LEGIENDTQP ILLQSCTGLV THRLLEEDTP RYMRASDPAS
60 70 80 90 100
PHIGRSNEEE ETSDSSLEKQ TRSKYCTETS GVHGDSPYGS GTMDTHSLES
110 120 130 140 150
KAERIARYKA ERRRQLAEKY GLTLDPEADS EYLSRYTKSR KEPDAVEKRG
160 170 180 190 200
GKSDKQEESS RDASSLYPGT ETMGLRTCAG ESKDYALHVG DGSSDPEVLL
210 220 230 240 250
NIENQRRGQE LSATRQAHDL SPAAESSSTF SFSGRDSSFT EVPRSPKHAH
260 270 280 290 300
SSSLQQAASR SPSFGDPQLS PEARPSTGKP KHEWFLQKDS EGDTPSLINW
310 320 330 340 350
PSRVKVREKL VKEESARNSP ELASESVTQR RHQPAPVHYV SFQSEHSAFD
360 370 380 390 400
RVPSKAAGST RQPIRGYVQP ADTGHTAKLV TPETPENASE CSWVASATQN
410 420 430 440 450
VPKPPSLTVL EGDGRDSPVL HVCESKAEEE EGEGEGEEKE EDVCFTEALE
460 470 480 490 500
QSKKTLLALE GDGLVRSPED PSRNEDFGKP AVSTVTLEHQ KELENVAQPP
510 520 530 540 550
QAPHQPTERT GRSEMVLYIQ SEPVSQDAKP TGHNREASKK RKVRTRSLSD
560 570 580 590 600
FTGPPQLQAL KYKDPASRRE LELPSSKTEG PYGEISMLDT KVSVAQLRSA
610 620 630 640 650
FLASANACRR PELKSRVERS AEGPGLPTGV ERERGSRKPR RYFSPGESRK
660 670 680 690 700
TSERFRTQPI TSAERKESDR CTSHSETPTV DDEEKVDERA KLSVAAKRLL
710 720 730 740 750
FREMEKSFDE QNVPKRRSRN TAVEQRLRRL QDRSLTQPIT TEEVVIAATE
760 770 780 790 800
PIPASCSGGT HPVMARLPSP TVARSAVQPA RLQASAHQKA LAKDQTNEGK
810 820 830 840 850
ELAEQGEPDS STLSLAEKLA LFNKLSQPVS KAISTRNRID TRQRRMNARY
860 870 880 890 900
QTQPVTLGEV EQVQSGKLIP FSPAVNTSVS TVASTVAPMY AGDLRTKPPL
910 920 930 940 950
DHNASATDYK FSSSIENSDS PVRSILKSQA WQPLVEGSEN KGMLREYGET
960 970 980 990 1000
ESKRALTGRD SGMEKYGSFE EAEASYPILN RAREGDSHKE SKYAVPRRGS
1010 1020 1030 1040 1050
LERANPPITH LGDEPKEFSM AKMNAQGNLD LRDRLPFEEK VEVENVMKRK
1060 1070 1080 1090 1100
FSLRAAEFGE PTSEQTGTAA GKTIAQTTAP VSWKPQDSSE QPQEKLCKNP
1110 1120 1130 1140 1150
CAMFAAGEIK TPTGEGLLDS PSKTMSIKER LALLKKSGEE DWRNRLSRRQ
1160 1170 1180 1190 1200
EGGKAPASSL HTQEAGRSLI KKRVTESRES QMTIEERKQL ITVREEAWKT
1210 1220 1230 1240 1250
RGRGAANDST QFTVAGRMVK KGLASPTAIT PVASPICGKT RGTTPVSKPL
1260 1270 1280 1290 1300
EDIEARPDMQ LESDLKLDRL ETFLRRLNNK VGGMHETVLT VTGKSVKEVM
1310 1320 1330 1340 1350
KPDDDETFAK FYRSVDYNMP RSPVEMDEDF DVIFDPYAPK LTSSVAEHKR
1360 1370 1380 1390 1400
AVRPKRRVQA SKNPLKMLAA REDLLQEYTE QRLNVAFMES KRMKVEKMSS
1410 1420 1430 1440 1450
NSNFSEVTLA GLASKENFSN VSLRSVNLTE QNSNNSAVPY KRLMLLQIKG
1460 1470 1480 1490 1500
RRHVQTRLVE PRASALNSGD CFLLLSPHCC FLWVGEFANV IEKAKASELA
1510 1520 1530 1540 1550
TLIQTKRELG CRATYIQTIE EGINTHTHAA KDFWKLLGGQ TSYQSAGDPK
1560 1570 1580 1590 1600
EDELYEAAII ETNCIYRLMD DKLVPDDDYW GKIPKCSLLQ PKEVLVFDFG
1610 1620 1630 1640 1650
SEVYVWHGKE VTLAQRKIAF QLAKHLWNGT FDYENCDINP LDPGECNPLI
1660 1670 1680 1690 1700
PRKGQGRPDW AIFGRLTEHN ETILFKEKFL DWTELKRSNE KNPGELAQHK
1710 1720 1730 1740 1750
EDPRTDVKAY DVTRMVSMPQ TTAGTILDGV NVGRGYGLVE GHDRRQFEIT
1760 1770 1780 1790 1800
SVSVDVWHIL EFDYSRLPKQ SIGQFHEGDA YVVKWKFMVS TAVGSRQKGE
1810 1820 1830 1840 1850
HSVRAAGKEK CVYFFWQGRH STVSEKGTSA LMTVELDEER GAQVQVLQGK
1860 1870 1880 1890 1900
EPPCFLQCFQ GGMVVHSGRR EEEEENVQSE WRLYCVRGEV PVEGNLLEVA
1910 1920 1930 1940 1950
CHCSSLRSRT SMVVLNVNKA LIYLWHGCKA QAHTKEVGRT AANKIKEQCP
1960 1970 1980 1990 2000
LEAGLHSSSK VTIHECDEGS EPLGFWDALG RRDRKAYDCM LQDPGSFNFA
2010 2020 2030 2040 2050
PRLFILSSSS GDFAATEFVY PARAPSVVSS MPFLQEDLYS APQPALFLVD
2060 2070 2080 2090 2100
NHHEVYLWQG WWPIENKITG SARIRWASDR KSAMETVLQY CKGKNLKKPA
2110 2120 2130 2140 2150
PKSYLIHAGL EPLTFTNMFP SWEHREDIAE ITEMDTEVSN QITLVEDVLA
2160 2170 2180 2190 2200
KLCKTIYPLA DLLARPLPEG VDPLKLEIYL TDEDFEFALD MTRDEYNALP
2210
AWKQVNLKKA KGLF
Length:2,214
Mass (Da):247,746
Last modified:July 7, 2009 - v2
Checksum:i6C4793D31FCBDF7C
GO
Isoform 2 (identifier: O95425-2) [UniParc]FASTAAdd to basket
Also known as: Supervillin1 Publication, p2051 Publication, SV1

The sequence of this isoform differs from the canonical sequence as follows:
     276-669: Missing.
     750-781: Missing.

Show »
Length:1,788
Mass (Da):200,847
Checksum:i03BDF48043A3CC8C
GO
Isoform SV3 (identifier: O95425-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-302: Missing.

Show »
Length:2,187
Mass (Da):244,679
Checksum:i112D7378B67AEED1
GO
Isoform SV4 (identifier: O95425-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     750-781: Missing.

Show »
Length:2,182
Mass (Da):244,523
Checksum:iD0DB0FB611E25EB4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020791189V → A.2 PublicationsCorresponds to variant rs10160013dbSNPEnsembl.1
Natural variantiVAR_058308422V → I.2 PublicationsCorresponds to variant rs1247696dbSNPEnsembl.1
Natural variantiVAR_0574671041V → L.Corresponds to variant rs7070135dbSNPEnsembl.1
Natural variantiVAR_0207921235P → A.Combined sources2 PublicationsCorresponds to variant rs2368406dbSNPEnsembl.1
Natural variantiVAR_0246911688S → P.Corresponds to variant rs11007612dbSNPEnsembl.1
Natural variantiVAR_0574682005I → V.Corresponds to variant rs7921306dbSNPEnsembl.1
Natural variantiVAR_0574692041A → V.Corresponds to variant rs17694739dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012425276 – 669Missing in isoform 2. 1 PublicationAdd BLAST394
Alternative sequenceiVSP_053768276 – 302Missing in isoform SV3. CuratedAdd BLAST27
Alternative sequenceiVSP_012426750 – 781Missing in isoform 2 and isoform SV4. 2 PublicationsAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051850 mRNA. Translation: AAC64695.1.
AF051851 mRNA. Translation: AAC64696.1.
AF109135 mRNA. Translation: AAD14682.1.
JX467682 mRNA. Translation: AGE81989.1.
AL160060, AL158167 Genomic DNA. Translation: CAH71300.1.
AL160060, AL158167 Genomic DNA. Translation: CAH71301.1.
AL158167, AL160060 Genomic DNA. Translation: CAI15237.1.
AL158167, AL160060 Genomic DNA. Translation: CAI15236.1.
CH471072 Genomic DNA. Translation: EAW86018.1.
CH471072 Genomic DNA. Translation: EAW86019.1.
CCDSiCCDS7163.1. [O95425-2]
CCDS7164.1. [O95425-1]
RefSeqiNP_003165.2. NM_003174.3. [O95425-2]
NP_068506.2. NM_021738.2. [O95425-1]
UniGeneiHs.499209.
Hs.684405.

Genome annotation databases

EnsembliENST00000355867; ENSP00000348128; ENSG00000197321. [O95425-1]
ENST00000375398; ENSP00000364547; ENSG00000197321. [O95425-4]
ENST00000375400; ENSP00000364549; ENSG00000197321. [O95425-2]
GeneIDi6840.
KEGGihsa:6840.
UCSCiuc001iut.2. human. [O95425-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051850 mRNA. Translation: AAC64695.1.
AF051851 mRNA. Translation: AAC64696.1.
AF109135 mRNA. Translation: AAD14682.1.
JX467682 mRNA. Translation: AGE81989.1.
AL160060, AL158167 Genomic DNA. Translation: CAH71300.1.
AL160060, AL158167 Genomic DNA. Translation: CAH71301.1.
AL158167, AL160060 Genomic DNA. Translation: CAI15237.1.
AL158167, AL160060 Genomic DNA. Translation: CAI15236.1.
CH471072 Genomic DNA. Translation: EAW86018.1.
CH471072 Genomic DNA. Translation: EAW86019.1.
CCDSiCCDS7163.1. [O95425-2]
CCDS7164.1. [O95425-1]
RefSeqiNP_003165.2. NM_003174.3. [O95425-2]
NP_068506.2. NM_021738.2. [O95425-1]
UniGeneiHs.499209.
Hs.684405.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K6MNMR-S2149-2214[»]
2K6NNMR-A2149-2214[»]
ProteinModelPortaliO95425.
SMRiO95425.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112707. 123 interactors.
IntActiO95425. 61 interactors.
MINTiMINT-1369291.
STRINGi9606.ENSP00000348128.

PTM databases

iPTMnetiO95425.
PhosphoSitePlusiO95425.

Polymorphism and mutation databases

BioMutaiSVIL.

Proteomic databases

EPDiO95425.
MaxQBiO95425.
PaxDbiO95425.
PeptideAtlasiO95425.
PRIDEiO95425.

Protocols and materials databases

DNASUi6840.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355867; ENSP00000348128; ENSG00000197321. [O95425-1]
ENST00000375398; ENSP00000364547; ENSG00000197321. [O95425-4]
ENST00000375400; ENSP00000364549; ENSG00000197321. [O95425-2]
GeneIDi6840.
KEGGihsa:6840.
UCSCiuc001iut.2. human. [O95425-1]

Organism-specific databases

CTDi6840.
DisGeNETi6840.
GeneCardsiSVIL.
H-InvDBHIX0008738.
HGNCiHGNC:11480. SVIL.
HPAiCAB010878.
HPA020095.
HPA020138.
MIMi604126. gene.
neXtProtiNX_O95425.
OpenTargetsiENSG00000197321.
PharmGKBiPA36265.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0445. Eukaryota.
ENOG410XPWY. LUCA.
GeneTreeiENSGT00760000119111.
HOVERGENiHBG052980.
InParanoidiO95425.
KOiK10369.
OMAiRSHTQPI.
OrthoDBiEOG091G00HK.
PhylomeDBiO95425.
TreeFamiTF316081.

Enzyme and pathway databases

BioCyciZFISH:G66-30954-MONOMER.

Miscellaneous databases

ChiTaRSiSVIL. human.
EvolutionaryTraceiO95425.
GeneWikiiSVIL.
GenomeRNAii6840.
PROiO95425.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197321.
CleanExiHS_SVIL.
ExpressionAtlasiO95425. baseline and differential.
GenevisibleiO95425. HS.

Family and domain databases

Gene3Di1.10.950.10. 1 hit.
3.40.20.10. 5 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR015628. SV/p205.
IPR007122. Villin/Gelsolin.
IPR003128. Villin_headpiece.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 2 hits.
PTHR11977:SF45. PTHR11977:SF45. 2 hits.
PfamiPF00626. Gelsolin. 1 hit.
PF02209. VHP. 1 hit.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 4 hits.
SM00153. VHP. 1 hit.
[Graphical view]
SUPFAMiSSF47050. SSF47050. 1 hit.
PROSITEiPS51089. HP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSVIL_HUMAN
AccessioniPrimary (citable) accession number: O95425
Secondary accession number(s): D3DRW9
, M1J557, O60611, O60612, Q5VZK5, Q5VZK6, Q9H1R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 7, 2009
Last modified: November 30, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.