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Protein

Dexamethasone-induced protein

Gene

DEXI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Dexamethasone-induced protein
Alternative name(s):
Protein MYLE
Gene namesi
Name:DEXI
Synonyms:MYLE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:13267. DEXI.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165449964.

Polymorphism and mutation databases

BioMutaiDEXI.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9595Dexamethasone-induced proteinPRO_0000096669Add
BLAST

Proteomic databases

PaxDbiO95424.
PRIDEiO95424.

Expressioni

Tissue specificityi

Highest levels in heart. Also expressed in brain, liver, pancreas, placenta and lung. Up-regulated in emphysematous lung compared to normal lung.1 Publication

Inductioni

By dexamethasone.1 Publication

Gene expression databases

BgeeiO95424.
GenevisibleiO95424. HS.

Organism-specific databases

HPAiHPA041511.

Interactioni

Protein-protein interaction databases

IntActiO95424. 3 interactions.
MINTiMINT-1421558.
STRINGi9606.ENSP00000330509.

Structurei

3D structure databases

ProteinModelPortaliO95424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DEXI family.Curated

Phylogenomic databases

eggNOGiENOG410J0RE. Eukaryota.
ENOG4111YRS. LUCA.
GeneTreeiENSGT00390000013271.
HOGENOMiHOG000112199.
HOVERGENiHBG094860.
InParanoidiO95424.
OMAiSVPYDTD.
OrthoDBiEOG7ZKSDM.
PhylomeDBiO95424.
TreeFamiTF338557.

Family and domain databases

InterProiIPR023259. Dexamethasone-induced.
[Graphical view]
PfamiPF15198. Dexa_ind. 1 hit.
[Graphical view]
PRINTSiPR02032. DEXMETHSNEIP.
ProDomiPD195637. Dexamethasone-induced. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

O95424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGARVAAHL DALGPLVPYV PPPLLPSMFY VGLFFVNVLI LYYAFLMEYI
60 70 80 90
VLNVGLVFLP EDMDQALVDL GVLSDPGSGL YDADSELDVF DAYLE
Length:95
Mass (Da):10,429
Last modified:August 14, 2001 - v2
Checksum:iF9F98DE2572D3F83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108145 mRNA. Translation: AAC83382.2.
AK314111 mRNA. Translation: BAG36804.1.
CH471112 Genomic DNA. Translation: EAW85167.1.
BC001083 mRNA. Translation: AAH01083.2.
BC037569 mRNA. Translation: AAH37569.1.
BC052989 mRNA. Translation: AAH52989.1.
BC071683 mRNA. Translation: AAH71683.1.
CCDSiCCDS10545.1.
RefSeqiNP_054734.2. NM_014015.3.
UniGeneiHs.592051.
Hs.659355.

Genome annotation databases

EnsembliENST00000331808; ENSP00000330509; ENSG00000182108.
ENST00000469379; ENSP00000482265; ENSG00000182108.
GeneIDi28955.
KEGGihsa:28955.
UCSCiuc002dal.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108145 mRNA. Translation: AAC83382.2.
AK314111 mRNA. Translation: BAG36804.1.
CH471112 Genomic DNA. Translation: EAW85167.1.
BC001083 mRNA. Translation: AAH01083.2.
BC037569 mRNA. Translation: AAH37569.1.
BC052989 mRNA. Translation: AAH52989.1.
BC071683 mRNA. Translation: AAH71683.1.
CCDSiCCDS10545.1.
RefSeqiNP_054734.2. NM_014015.3.
UniGeneiHs.592051.
Hs.659355.

3D structure databases

ProteinModelPortaliO95424.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO95424. 3 interactions.
MINTiMINT-1421558.
STRINGi9606.ENSP00000330509.

Polymorphism and mutation databases

BioMutaiDEXI.

Proteomic databases

PaxDbiO95424.
PRIDEiO95424.

Protocols and materials databases

DNASUi28955.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331808; ENSP00000330509; ENSG00000182108.
ENST00000469379; ENSP00000482265; ENSG00000182108.
GeneIDi28955.
KEGGihsa:28955.
UCSCiuc002dal.4. human.

Organism-specific databases

CTDi28955.
GeneCardsiDEXI.
H-InvDBHIX0019242.
HIX0172763.
HGNCiHGNC:13267. DEXI.
HPAiHPA041511.
neXtProtiNX_O95424.
PharmGKBiPA165449964.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0RE. Eukaryota.
ENOG4111YRS. LUCA.
GeneTreeiENSGT00390000013271.
HOGENOMiHOG000112199.
HOVERGENiHBG094860.
InParanoidiO95424.
OMAiSVPYDTD.
OrthoDBiEOG7ZKSDM.
PhylomeDBiO95424.
TreeFamiTF338557.

Miscellaneous databases

ChiTaRSiDEXI. human.
GenomeRNAii28955.
PROiO95424.

Gene expression databases

BgeeiO95424.
GenevisibleiO95424. HS.

Family and domain databases

InterProiIPR023259. Dexamethasone-induced.
[Graphical view]
PfamiPF15198. Dexa_ind. 1 hit.
[Graphical view]
PRINTSiPR02032. DEXMETHSNEIP.
ProDomiPD195637. Dexamethasone-induced. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of dexamethasone-induced transcript: a novel glucocorticoid-induced gene that is upregulated in emphysema."
    Edgar A.J., Birks E.J., Yacoub M.H., Polak J.M.
    Am. J. Respir. Cell Mol. Biol. 25:119-124(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    Tissue: Lung.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon, Kidney and PNS.

Entry informationi

Entry nameiDEXI_HUMAN
AccessioniPrimary (citable) accession number: O95424
Secondary accession number(s): B2RAA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 14, 2001
Last modified: June 8, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.