ID   SOX14_HUMAN             Reviewed;         240 AA.
AC   O95416; B2RAC0; Q3KPH7;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   27-MAR-2024, entry version 184.
DE   RecName: Full=Transcription factor SOX-14;
DE   AltName: Full=Protein SOX-28;
GN   Name=SOX14; Synonyms=SOX28;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10441749; DOI=10.1007/s003359901118;
RA   Malas S., Duthie S., Deloukas P., Episkopou V.;
RT   "The isolation and high-resolution chromosomal mapping of human SOX14 and
RT   SOX21; two members of the SOX gene family related to SOX1, SOX2, and
RT   SOX3.";
RL   Mamm. Genome 10:934-937(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9925951; DOI=10.1159/000015149;
RA   Arsic N., Rajic T., Stanojcic S., Goodfellow P.N., Stevanovic M.;
RT   "Characterisation and mapping of the human SOX14 gene.";
RL   Cytogenet. Cell Genet. 83:139-146(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10830911; DOI=10.1007/s004390000266;
RA   Hargrave M., James K., Nield K., Toomes C., Georgas K., Sullivan T.,
RA   Verzijl H.T., Oley C.A., Little M., De Jonghe P., Kwon J.M., Kremer H.,
RA   Dixon M.J., Timmerman V., Yamada T., Koopman P.;
RT   "Fine mapping of the neurally expressed gene SOX14 to human 3q23, relative
RT   to three congenital diseases.";
RL   Hum. Genet. 106:432-439(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Substantia nigra;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-72.
RX   PubMed=9827568; DOI=10.1016/s0014-5793(98)01294-0;
RA   Cremazy F., Soullier S., Berta P., Jay P.;
RT   "Further complexity of the human SOX gene family revealed by the combined
RT   use of highly degenerate primers and nested PCR.";
RL   FEBS Lett. 438:311-314(1998).
CC   -!- FUNCTION: Acts as a negative regulator of transcription. {ECO:0000250}.
CC   -!- INTERACTION:
CC       O95416; O00213-2: APBB1; NbExp=3; IntAct=EBI-9087806, EBI-13307975;
CC       O95416; P54253: ATXN1; NbExp=3; IntAct=EBI-9087806, EBI-930964;
CC       O95416; P54252: ATXN3; NbExp=3; IntAct=EBI-9087806, EBI-946046;
CC       O95416; O43186: CRX; NbExp=3; IntAct=EBI-9087806, EBI-748171;
CC       O95416; O75593: FOXH1; NbExp=3; IntAct=EBI-9087806, EBI-1759806;
CC       O95416; P28799-2: GRN; NbExp=3; IntAct=EBI-9087806, EBI-25860013;
CC       O95416; P42858: HTT; NbExp=12; IntAct=EBI-9087806, EBI-466029;
CC       O95416; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-9087806, EBI-11992140;
CC       O95416; Q69YI7: NAIF1; NbExp=4; IntAct=EBI-9087806, EBI-10249231;
CC       O95416; P04150: NR3C1; NbExp=3; IntAct=EBI-9087806, EBI-493507;
CC       O95416; P49810: PSEN2; NbExp=3; IntAct=EBI-9087806, EBI-2010251;
CC       O95416; Q01974: ROR2; NbExp=5; IntAct=EBI-9087806, EBI-6422642;
CC       O95416; Q96LM6: SPMIP9; NbExp=3; IntAct=EBI-9087806, EBI-743976;
CC       O95416; P21980-2: TGM2; NbExp=3; IntAct=EBI-9087806, EBI-25842075;
CC       O95416; P31930: UQCRC1; NbExp=3; IntAct=EBI-9087806, EBI-1052596;
CC       O95416; O95231: VENTX; NbExp=3; IntAct=EBI-9087806, EBI-10191303;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
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DR   EMBL; AF107043; AAC95380.1; -; Genomic_DNA.
DR   EMBL; AJ006230; CAB43111.1; -; Genomic_DNA.
DR   EMBL; AF193436; AAF76294.1; -; Genomic_DNA.
DR   EMBL; AK314127; BAG36817.1; -; mRNA.
DR   EMBL; CH471052; EAW79097.1; -; Genomic_DNA.
DR   EMBL; BC106729; AAI06730.1; -; mRNA.
DR   EMBL; BC106730; AAI06731.1; -; mRNA.
DR   EMBL; AF032451; AAC94971.1; -; Genomic_DNA.
DR   CCDS; CCDS3094.1; -.
DR   RefSeq; NP_004180.1; NM_004189.3.
DR   AlphaFoldDB; O95416; -.
DR   SMR; O95416; -.
DR   BioGRID; 113991; 10.
DR   IntAct; O95416; 19.
DR   STRING; 9606.ENSP00000305343; -.
DR   iPTMnet; O95416; -.
DR   PhosphoSitePlus; O95416; -.
DR   BioMuta; SOX14; -.
DR   jPOST; O95416; -.
DR   MassIVE; O95416; -.
DR   MaxQB; O95416; -.
DR   PaxDb; 9606-ENSP00000305343; -.
DR   PeptideAtlas; O95416; -.
DR   Antibodypedia; 17867; 165 antibodies from 25 providers.
DR   DNASU; 8403; -.
DR   Ensembl; ENST00000306087.3; ENSP00000305343.1; ENSG00000168875.3.
DR   GeneID; 8403; -.
DR   KEGG; hsa:8403; -.
DR   MANE-Select; ENST00000306087.3; ENSP00000305343.1; NM_004189.4; NP_004180.1.
DR   UCSC; uc003erm.3; human.
DR   AGR; HGNC:11193; -.
DR   CTD; 8403; -.
DR   DisGeNET; 8403; -.
DR   GeneCards; SOX14; -.
DR   HGNC; HGNC:11193; SOX14.
DR   HPA; ENSG00000168875; Tissue enhanced (brain, placenta).
DR   MIM; 604747; gene.
DR   neXtProt; NX_O95416; -.
DR   OpenTargets; ENSG00000168875; -.
DR   PharmGKB; PA36030; -.
DR   VEuPathDB; HostDB:ENSG00000168875; -.
DR   eggNOG; KOG0527; Eukaryota.
DR   GeneTree; ENSGT00940000160749; -.
DR   HOGENOM; CLU_021123_3_1_1; -.
DR   InParanoid; O95416; -.
DR   OMA; KMTQEMP; -.
DR   OrthoDB; 2902801at2759; -.
DR   PhylomeDB; O95416; -.
DR   TreeFam; TF351735; -.
DR   PathwayCommons; O95416; -.
DR   SignaLink; O95416; -.
DR   BioGRID-ORCS; 8403; 13 hits in 1160 CRISPR screens.
DR   GeneWiki; SOX14; -.
DR   GenomeRNAi; 8403; -.
DR   Pharos; O95416; Tbio.
DR   PRO; PR:O95416; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; O95416; Protein.
DR   Bgee; ENSG00000168875; Expressed in placenta and 7 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0009649; P:entrainment of circadian clock; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; TAS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:2001222; P:regulation of neuron migration; IEA:Ensembl.
DR   GO; GO:0007601; P:visual perception; IEA:Ensembl.
DR   CDD; cd01388; HMG-box_SoxB; 1.
DR   Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR022097; SOX_fam.
DR   PANTHER; PTHR10270; SOX TRANSCRIPTION FACTOR; 1.
DR   PANTHER; PTHR10270:SF107; TRANSCRIPTION FACTOR SOX-14; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF12336; SOXp; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; HMG-box; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
DR   Genevisible; O95416; HS.
PE   1: Evidence at protein level;
KW   DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..240
FT                   /note="Transcription factor SOX-14"
FT                   /id="PRO_0000048758"
FT   DNA_BIND        8..76
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
SQ   SEQUENCE   240 AA;  26485 MW;  7F574AFDA571D903 CRC64;
     MSKPSDHIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS EAEKRPYIDE
     AKRLRAQHMK EHPDYKYRPR RKPKNLLKKD RYVFPLPYLG DTDPLKAAGL PVGASDGLLS
     APEKARAFLP PASAPYSLLD PAQFSSSAIQ KMGEVPHTLA TGALPYASTL GYQNGAFGSL
     SCPSQHTHTH PSPTNPGYVV PCNCTAWSAS TLQPPVAYIL FPGMTKTGID PYSSAHATAM
//