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O95416

- SOX14_HUMAN

UniProt

O95416 - SOX14_HUMAN

Protein

Transcription factor SOX-14

Gene

SOX14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Acts as a negative regulator of transcription.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi8 – 7669HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: UniProtKB
    2. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    3. nervous system development Source: UniProtKB
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor SOX-14
    Alternative name(s):
    Protein SOX-28
    Gene namesi
    Name:SOX14
    Synonyms:SOX28
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:11193. SOX14.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36030.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 240240Transcription factor SOX-14PRO_0000048758Add
    BLAST

    Proteomic databases

    PaxDbiO95416.
    PRIDEiO95416.

    PTM databases

    PhosphoSiteiO95416.

    Expressioni

    Gene expression databases

    BgeeiO95416.
    CleanExiHS_SOX14.
    GenevestigatoriO95416.

    Interactioni

    Protein-protein interaction databases

    IntActiO95416. 1 interaction.
    STRINGi9606.ENSP00000305343.

    Structurei

    3D structure databases

    ProteinModelPortaliO95416.
    SMRiO95416. Positions 6-82.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG302715.
    HOGENOMiHOG000231647.
    HOVERGENiHBG105618.
    InParanoidiO95416.
    KOiK09267.
    OMAiTLGCPSQ.
    OrthoDBiEOG7TMZVP.
    PhylomeDBiO95416.
    TreeFamiTF351735.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR029549. SOX-14.
    IPR022097. TF_SOX.
    [Graphical view]
    PANTHERiPTHR10270:SF107. PTHR10270:SF107. 1 hit.
    PfamiPF00505. HMG_box. 1 hit.
    PF12336. SOXp. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95416-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKPSDHIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS    50
    EAEKRPYIDE AKRLRAQHMK EHPDYKYRPR RKPKNLLKKD RYVFPLPYLG 100
    DTDPLKAAGL PVGASDGLLS APEKARAFLP PASAPYSLLD PAQFSSSAIQ 150
    KMGEVPHTLA TGALPYASTL GYQNGAFGSL SCPSQHTHTH PSPTNPGYVV 200
    PCNCTAWSAS TLQPPVAYIL FPGMTKTGID PYSSAHATAM 240
    Length:240
    Mass (Da):26,485
    Last modified:May 1, 1999 - v1
    Checksum:i7F574AFDA571D903
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF107043 Genomic DNA. Translation: AAC95380.1.
    AJ006230 Genomic DNA. Translation: CAB43111.1.
    AF193436 Genomic DNA. Translation: AAF76294.1.
    AK314127 mRNA. Translation: BAG36817.1.
    CH471052 Genomic DNA. Translation: EAW79097.1.
    BC106729 mRNA. Translation: AAI06730.1.
    BC106730 mRNA. Translation: AAI06731.1.
    AF032451 Genomic DNA. Translation: AAC94971.1.
    CCDSiCCDS3094.1.
    RefSeqiNP_004180.1. NM_004189.3.
    UniGeneiHs.248184.

    Genome annotation databases

    EnsembliENST00000306087; ENSP00000305343; ENSG00000168875.
    GeneIDi8403.
    KEGGihsa:8403.
    UCSCiuc003erm.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF107043 Genomic DNA. Translation: AAC95380.1 .
    AJ006230 Genomic DNA. Translation: CAB43111.1 .
    AF193436 Genomic DNA. Translation: AAF76294.1 .
    AK314127 mRNA. Translation: BAG36817.1 .
    CH471052 Genomic DNA. Translation: EAW79097.1 .
    BC106729 mRNA. Translation: AAI06730.1 .
    BC106730 mRNA. Translation: AAI06731.1 .
    AF032451 Genomic DNA. Translation: AAC94971.1 .
    CCDSi CCDS3094.1.
    RefSeqi NP_004180.1. NM_004189.3.
    UniGenei Hs.248184.

    3D structure databases

    ProteinModelPortali O95416.
    SMRi O95416. Positions 6-82.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O95416. 1 interaction.
    STRINGi 9606.ENSP00000305343.

    PTM databases

    PhosphoSitei O95416.

    Proteomic databases

    PaxDbi O95416.
    PRIDEi O95416.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306087 ; ENSP00000305343 ; ENSG00000168875 .
    GeneIDi 8403.
    KEGGi hsa:8403.
    UCSCi uc003erm.2. human.

    Organism-specific databases

    CTDi 8403.
    GeneCardsi GC03P137483.
    HGNCi HGNC:11193. SOX14.
    MIMi 604747. gene.
    neXtProti NX_O95416.
    PharmGKBi PA36030.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG302715.
    HOGENOMi HOG000231647.
    HOVERGENi HBG105618.
    InParanoidi O95416.
    KOi K09267.
    OMAi TLGCPSQ.
    OrthoDBi EOG7TMZVP.
    PhylomeDBi O95416.
    TreeFami TF351735.

    Miscellaneous databases

    GeneWikii SOX14.
    GenomeRNAii 8403.
    NextBioi 31446.
    PROi O95416.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95416.
    CleanExi HS_SOX14.
    Genevestigatori O95416.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR029549. SOX-14.
    IPR022097. TF_SOX.
    [Graphical view ]
    PANTHERi PTHR10270:SF107. PTHR10270:SF107. 1 hit.
    Pfami PF00505. HMG_box. 1 hit.
    PF12336. SOXp. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3."
      Malas S., Duthie S., Deloukas P., Episkopou V.
      Mamm. Genome 10:934-937(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Characterisation and mapping of the human SOX14 gene."
      Arsic N., Rajic T., Stanojcic S., Goodfellow P.N., Stevanovic M.
      Cytogenet. Cell Genet. 83:139-146(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Fine mapping of the neurally expressed gene SOX14 to human 3q23, relative to three congenital diseases."
      Hargrave M., James K., Nield K., Toomes C., Georgas K., Sullivan T., Verzijl H.T., Oley C.A., Little M., De Jonghe P., Kwon J.M., Kremer H., Dixon M.J., Timmerman V., Yamada T., Koopman P.
      Hum. Genet. 106:432-439(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Substantia nigra.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR."
      Cremazy F., Soullier S., Berta P., Jay P.
      FEBS Lett. 438:311-314(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-72.

    Entry informationi

    Entry nameiSOX14_HUMAN
    AccessioniPrimary (citable) accession number: O95416
    Secondary accession number(s): B2RAC0, Q3KPH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3