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Protein

Transcription factor SOX-14

Gene

SOX14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of transcription.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi8 – 7669HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-14
Alternative name(s):
Protein SOX-28
Gene namesi
Name:SOX14
Synonyms:SOX28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:11193. SOX14.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36030.

Polymorphism and mutation databases

BioMutaiSOX14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Transcription factor SOX-14PRO_0000048758Add
BLAST

Proteomic databases

PaxDbiO95416.
PRIDEiO95416.

PTM databases

PhosphoSiteiO95416.

Expressioni

Gene expression databases

BgeeiO95416.
CleanExiHS_SOX14.
GenevisibleiO95416. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NAIF1Q69YI73EBI-9087806,EBI-10249231

Protein-protein interaction databases

BioGridi113991. 3 interactions.
IntActiO95416. 2 interactions.
STRINGi9606.ENSP00000305343.

Structurei

3D structure databases

ProteinModelPortaliO95416.
SMRiO95416. Positions 6-82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG302715.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG105618.
InParanoidiO95416.
KOiK09267.
OMAiYSSAHAA.
OrthoDBiEOG7TMZVP.
PhylomeDBiO95416.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR029549. SOX-14.
IPR022097. TF_SOX.
[Graphical view]
PANTHERiPTHR10270:SF107. PTHR10270:SF107. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPSDHIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS
60 70 80 90 100
EAEKRPYIDE AKRLRAQHMK EHPDYKYRPR RKPKNLLKKD RYVFPLPYLG
110 120 130 140 150
DTDPLKAAGL PVGASDGLLS APEKARAFLP PASAPYSLLD PAQFSSSAIQ
160 170 180 190 200
KMGEVPHTLA TGALPYASTL GYQNGAFGSL SCPSQHTHTH PSPTNPGYVV
210 220 230 240
PCNCTAWSAS TLQPPVAYIL FPGMTKTGID PYSSAHATAM
Length:240
Mass (Da):26,485
Last modified:May 1, 1999 - v1
Checksum:i7F574AFDA571D903
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107043 Genomic DNA. Translation: AAC95380.1.
AJ006230 Genomic DNA. Translation: CAB43111.1.
AF193436 Genomic DNA. Translation: AAF76294.1.
AK314127 mRNA. Translation: BAG36817.1.
CH471052 Genomic DNA. Translation: EAW79097.1.
BC106729 mRNA. Translation: AAI06730.1.
BC106730 mRNA. Translation: AAI06731.1.
AF032451 Genomic DNA. Translation: AAC94971.1.
CCDSiCCDS3094.1.
RefSeqiNP_004180.1. NM_004189.3.
UniGeneiHs.248184.

Genome annotation databases

EnsembliENST00000306087; ENSP00000305343; ENSG00000168875.
GeneIDi8403.
KEGGihsa:8403.
UCSCiuc003erm.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107043 Genomic DNA. Translation: AAC95380.1.
AJ006230 Genomic DNA. Translation: CAB43111.1.
AF193436 Genomic DNA. Translation: AAF76294.1.
AK314127 mRNA. Translation: BAG36817.1.
CH471052 Genomic DNA. Translation: EAW79097.1.
BC106729 mRNA. Translation: AAI06730.1.
BC106730 mRNA. Translation: AAI06731.1.
AF032451 Genomic DNA. Translation: AAC94971.1.
CCDSiCCDS3094.1.
RefSeqiNP_004180.1. NM_004189.3.
UniGeneiHs.248184.

3D structure databases

ProteinModelPortaliO95416.
SMRiO95416. Positions 6-82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113991. 3 interactions.
IntActiO95416. 2 interactions.
STRINGi9606.ENSP00000305343.

PTM databases

PhosphoSiteiO95416.

Polymorphism and mutation databases

BioMutaiSOX14.

Proteomic databases

PaxDbiO95416.
PRIDEiO95416.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306087; ENSP00000305343; ENSG00000168875.
GeneIDi8403.
KEGGihsa:8403.
UCSCiuc003erm.2. human.

Organism-specific databases

CTDi8403.
GeneCardsiGC03P137483.
HGNCiHGNC:11193. SOX14.
MIMi604747. gene.
neXtProtiNX_O95416.
PharmGKBiPA36030.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG302715.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG105618.
InParanoidiO95416.
KOiK09267.
OMAiYSSAHAA.
OrthoDBiEOG7TMZVP.
PhylomeDBiO95416.
TreeFamiTF351735.

Miscellaneous databases

GeneWikiiSOX14.
GenomeRNAii8403.
NextBioi31446.
PROiO95416.
SOURCEiSearch...

Gene expression databases

BgeeiO95416.
CleanExiHS_SOX14.
GenevisibleiO95416. HS.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR029549. SOX-14.
IPR022097. TF_SOX.
[Graphical view]
PANTHERiPTHR10270:SF107. PTHR10270:SF107. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3."
    Malas S., Duthie S., Deloukas P., Episkopou V.
    Mamm. Genome 10:934-937(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Characterisation and mapping of the human SOX14 gene."
    Arsic N., Rajic T., Stanojcic S., Goodfellow P.N., Stevanovic M.
    Cytogenet. Cell Genet. 83:139-146(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Fine mapping of the neurally expressed gene SOX14 to human 3q23, relative to three congenital diseases."
    Hargrave M., James K., Nield K., Toomes C., Georgas K., Sullivan T., Verzijl H.T., Oley C.A., Little M., De Jonghe P., Kwon J.M., Kremer H., Dixon M.J., Timmerman V., Yamada T., Koopman P.
    Hum. Genet. 106:432-439(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Substantia nigra.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR."
    Cremazy F., Soullier S., Berta P., Jay P.
    FEBS Lett. 438:311-314(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-72.

Entry informationi

Entry nameiSOX14_HUMAN
AccessioniPrimary (citable) accession number: O95416
Secondary accession number(s): B2RAC0, Q3KPH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 24, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.