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O95416

- SOX14_HUMAN

UniProt

O95416 - SOX14_HUMAN

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Protein

Transcription factor SOX-14

Gene

SOX14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Acts as a negative regulator of transcription.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi8 – 7669HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. sequence-specific DNA binding Source: UniProtKB
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl

GO - Biological processi

  1. entrainment of circadian clock Source: Ensembl
  2. negative regulation of transcription, DNA-templated Source: UniProtKB
  3. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  4. nervous system development Source: UniProtKB
  5. regulation of neuron migration Source: Ensembl
  6. visual perception Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-14
Alternative name(s):
Protein SOX-28
Gene namesi
Name:SOX14
Synonyms:SOX28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:11193. SOX14.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nuclear transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Transcription factor SOX-14PRO_0000048758Add
BLAST

Proteomic databases

PaxDbiO95416.
PRIDEiO95416.

PTM databases

PhosphoSiteiO95416.

Expressioni

Gene expression databases

BgeeiO95416.
CleanExiHS_SOX14.
GenevestigatoriO95416.

Interactioni

Protein-protein interaction databases

BioGridi113991. 1 interaction.
IntActiO95416. 1 interaction.
STRINGi9606.ENSP00000305343.

Structurei

3D structure databases

ProteinModelPortaliO95416.
SMRiO95416. Positions 6-82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG302715.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG105618.
InParanoidiO95416.
KOiK09267.
OMAiTLGCPSQ.
OrthoDBiEOG7TMZVP.
PhylomeDBiO95416.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR029549. SOX-14.
IPR022097. TF_SOX.
[Graphical view]
PANTHERiPTHR10270:SF107. PTHR10270:SF107. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95416-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKPSDHIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS
60 70 80 90 100
EAEKRPYIDE AKRLRAQHMK EHPDYKYRPR RKPKNLLKKD RYVFPLPYLG
110 120 130 140 150
DTDPLKAAGL PVGASDGLLS APEKARAFLP PASAPYSLLD PAQFSSSAIQ
160 170 180 190 200
KMGEVPHTLA TGALPYASTL GYQNGAFGSL SCPSQHTHTH PSPTNPGYVV
210 220 230 240
PCNCTAWSAS TLQPPVAYIL FPGMTKTGID PYSSAHATAM
Length:240
Mass (Da):26,485
Last modified:May 1, 1999 - v1
Checksum:i7F574AFDA571D903
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107043 Genomic DNA. Translation: AAC95380.1.
AJ006230 Genomic DNA. Translation: CAB43111.1.
AF193436 Genomic DNA. Translation: AAF76294.1.
AK314127 mRNA. Translation: BAG36817.1.
CH471052 Genomic DNA. Translation: EAW79097.1.
BC106729 mRNA. Translation: AAI06730.1.
BC106730 mRNA. Translation: AAI06731.1.
AF032451 Genomic DNA. Translation: AAC94971.1.
CCDSiCCDS3094.1.
RefSeqiNP_004180.1. NM_004189.3.
UniGeneiHs.248184.

Genome annotation databases

EnsembliENST00000306087; ENSP00000305343; ENSG00000168875.
GeneIDi8403.
KEGGihsa:8403.
UCSCiuc003erm.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107043 Genomic DNA. Translation: AAC95380.1 .
AJ006230 Genomic DNA. Translation: CAB43111.1 .
AF193436 Genomic DNA. Translation: AAF76294.1 .
AK314127 mRNA. Translation: BAG36817.1 .
CH471052 Genomic DNA. Translation: EAW79097.1 .
BC106729 mRNA. Translation: AAI06730.1 .
BC106730 mRNA. Translation: AAI06731.1 .
AF032451 Genomic DNA. Translation: AAC94971.1 .
CCDSi CCDS3094.1.
RefSeqi NP_004180.1. NM_004189.3.
UniGenei Hs.248184.

3D structure databases

ProteinModelPortali O95416.
SMRi O95416. Positions 6-82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113991. 1 interaction.
IntActi O95416. 1 interaction.
STRINGi 9606.ENSP00000305343.

PTM databases

PhosphoSitei O95416.

Proteomic databases

PaxDbi O95416.
PRIDEi O95416.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306087 ; ENSP00000305343 ; ENSG00000168875 .
GeneIDi 8403.
KEGGi hsa:8403.
UCSCi uc003erm.2. human.

Organism-specific databases

CTDi 8403.
GeneCardsi GC03P137483.
HGNCi HGNC:11193. SOX14.
MIMi 604747. gene.
neXtProti NX_O95416.
PharmGKBi PA36030.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG302715.
GeneTreei ENSGT00760000118988.
HOGENOMi HOG000231647.
HOVERGENi HBG105618.
InParanoidi O95416.
KOi K09267.
OMAi TLGCPSQ.
OrthoDBi EOG7TMZVP.
PhylomeDBi O95416.
TreeFami TF351735.

Miscellaneous databases

GeneWikii SOX14.
GenomeRNAii 8403.
NextBioi 31446.
PROi O95416.
SOURCEi Search...

Gene expression databases

Bgeei O95416.
CleanExi HS_SOX14.
Genevestigatori O95416.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
IPR029549. SOX-14.
IPR022097. TF_SOX.
[Graphical view ]
PANTHERi PTHR10270:SF107. PTHR10270:SF107. 1 hit.
Pfami PF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3."
    Malas S., Duthie S., Deloukas P., Episkopou V.
    Mamm. Genome 10:934-937(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Characterisation and mapping of the human SOX14 gene."
    Arsic N., Rajic T., Stanojcic S., Goodfellow P.N., Stevanovic M.
    Cytogenet. Cell Genet. 83:139-146(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Fine mapping of the neurally expressed gene SOX14 to human 3q23, relative to three congenital diseases."
    Hargrave M., James K., Nield K., Toomes C., Georgas K., Sullivan T., Verzijl H.T., Oley C.A., Little M., De Jonghe P., Kwon J.M., Kremer H., Dixon M.J., Timmerman V., Yamada T., Koopman P.
    Hum. Genet. 106:432-439(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Substantia nigra.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR."
    Cremazy F., Soullier S., Berta P., Jay P.
    FEBS Lett. 438:311-314(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-72.

Entry informationi

Entry nameiSOX14_HUMAN
AccessioniPrimary (citable) accession number: O95416
Secondary accession number(s): B2RAC0, Q3KPH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3