Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor SOX-14

Gene

SOX14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of transcription.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi8 – 76HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-14
Alternative name(s):
Protein SOX-28
Gene namesi
Name:SOX14
Synonyms:SOX28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:11193. SOX14.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8403.
OpenTargetsiENSG00000168875.
PharmGKBiPA36030.

Polymorphism and mutation databases

BioMutaiSOX14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487581 – 240Transcription factor SOX-14Add BLAST240

Proteomic databases

MaxQBiO95416.
PaxDbiO95416.
PeptideAtlasiO95416.
PRIDEiO95416.

PTM databases

iPTMnetiO95416.
PhosphoSitePlusiO95416.

Expressioni

Gene expression databases

BgeeiENSG00000168875.
CleanExiHS_SOX14.
GenevisibleiO95416. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NAIF1Q69YI73EBI-9087806,EBI-10249231

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113991. 3 interactors.
IntActiO95416. 8 interactors.
STRINGi9606.ENSP00000305343.

Structurei

3D structure databases

ProteinModelPortaliO95416.
SMRiO95416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IPZF. Eukaryota.
ENOG41115Y8. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG105618.
InParanoidiO95416.
KOiK09267.
OMAiLGCPSQH.
OrthoDBiEOG091G0F15.
PhylomeDBiO95416.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
IPR022097. SOX_fam.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O95416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPSDHIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS
60 70 80 90 100
EAEKRPYIDE AKRLRAQHMK EHPDYKYRPR RKPKNLLKKD RYVFPLPYLG
110 120 130 140 150
DTDPLKAAGL PVGASDGLLS APEKARAFLP PASAPYSLLD PAQFSSSAIQ
160 170 180 190 200
KMGEVPHTLA TGALPYASTL GYQNGAFGSL SCPSQHTHTH PSPTNPGYVV
210 220 230 240
PCNCTAWSAS TLQPPVAYIL FPGMTKTGID PYSSAHATAM
Length:240
Mass (Da):26,485
Last modified:May 1, 1999 - v1
Checksum:i7F574AFDA571D903
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107043 Genomic DNA. Translation: AAC95380.1.
AJ006230 Genomic DNA. Translation: CAB43111.1.
AF193436 Genomic DNA. Translation: AAF76294.1.
AK314127 mRNA. Translation: BAG36817.1.
CH471052 Genomic DNA. Translation: EAW79097.1.
BC106729 mRNA. Translation: AAI06730.1.
BC106730 mRNA. Translation: AAI06731.1.
AF032451 Genomic DNA. Translation: AAC94971.1.
CCDSiCCDS3094.1.
RefSeqiNP_004180.1. NM_004189.3.
UniGeneiHs.248184.

Genome annotation databases

EnsembliENST00000306087; ENSP00000305343; ENSG00000168875.
GeneIDi8403.
KEGGihsa:8403.
UCSCiuc003erm.3. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSOX14_HUMAN
AccessioniPrimary (citable) accession number: O95416
Secondary accession number(s): B2RAC0, Q3KPH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 10, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot