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Protein

Brain protein I3

Gene

BRI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • identical protein binding Source: MGI
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164713-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Brain protein I3
Alternative name(s):
pRGR2
Gene namesi
Name:BRI3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:1109. BRI3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei67 – 86HelicalSequence analysisAdd BLAST20
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi25798.
OpenTargetsiENSG00000164713.
PharmGKBiPA25422.

Polymorphism and mutation databases

BioMutaiBRI3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000649231 – 125Brain protein I3Add BLAST125

Proteomic databases

EPDiO95415.
MaxQBiO95415.
PaxDbiO95415.
PeptideAtlasiO95415.
PRIDEiO95415.

PTM databases

iPTMnetiO95415.
PhosphoSitePlusiO95415.

Expressioni

Gene expression databases

BgeeiENSG00000164713.
CleanExiHS_BRI3.
ExpressionAtlasiO95415. baseline and differential.
GenevisibleiO95415. HS.

Organism-specific databases

HPAiHPA042215.

Interactioni

GO - Molecular functioni

  • identical protein binding Source: MGI

Protein-protein interaction databases

BioGridi117330. 2 interactors.
IntActiO95415. 1 interactor.
STRINGi9606.ENSP00000297290.

Structurei

3D structure databases

ProteinModelPortaliO95415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 43Poly-Pro7

Sequence similaritiesi

Belongs to the BRI3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4517. Eukaryota.
ENOG41121JM. LUCA.
GeneTreeiENSGT00510000048486.
HOGENOMiHOG000035090.
HOVERGENiHBG104957.
InParanoidiO95415.
OMAiNIHSRAV.
OrthoDBiEOG091G18Q7.
PhylomeDBiO95415.
TreeFamiTF329242.

Family and domain databases

InterProiIPR019317. Brain_I3.
[Graphical view]
PANTHERiPTHR13551. PTHR13551. 1 hit.
PfamiPF10164. DUF2367. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHKPLLQER PPAYNLEAGQ GDYACGPHGY GAIPAAPPPP PYPYLVTGIP
60 70 80 90 100
THHPRVYNIH SRTVTRYPAN SIVVVGGCPV CRVGVLEDCF TFLGIFLAII
110 120
LFPFGFICCF ALRKRRCPNC GATFA
Length:125
Mass (Da):13,645
Last modified:May 1, 1999 - v1
Checksum:iABBFADD00E91C52C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53H → Y in AAH18737 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033516123T → A.Corresponds to variant rs12865dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106966 mRNA. Translation: AAD05167.1.
AB055977 mRNA. Translation: BAB32785.1.
AF041430 mRNA. Translation: AAF18565.2.
CH471091 Genomic DNA. Translation: EAW76713.1.
CH471091 Genomic DNA. Translation: EAW76714.1.
CH471091 Genomic DNA. Translation: EAW76715.1.
BC018737 mRNA. Translation: AAH18737.1.
BC062370 mRNA. Translation: AAH62370.1.
CCDSiCCDS5656.1.
RefSeqiNP_056194.1. NM_015379.4.
UniGeneiHs.567438.

Genome annotation databases

EnsembliENST00000297290; ENSP00000297290; ENSG00000164713.
GeneIDi25798.
KEGGihsa:25798.
UCSCiuc003upi.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106966 mRNA. Translation: AAD05167.1.
AB055977 mRNA. Translation: BAB32785.1.
AF041430 mRNA. Translation: AAF18565.2.
CH471091 Genomic DNA. Translation: EAW76713.1.
CH471091 Genomic DNA. Translation: EAW76714.1.
CH471091 Genomic DNA. Translation: EAW76715.1.
BC018737 mRNA. Translation: AAH18737.1.
BC062370 mRNA. Translation: AAH62370.1.
CCDSiCCDS5656.1.
RefSeqiNP_056194.1. NM_015379.4.
UniGeneiHs.567438.

3D structure databases

ProteinModelPortaliO95415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117330. 2 interactors.
IntActiO95415. 1 interactor.
STRINGi9606.ENSP00000297290.

PTM databases

iPTMnetiO95415.
PhosphoSitePlusiO95415.

Polymorphism and mutation databases

BioMutaiBRI3.

Proteomic databases

EPDiO95415.
MaxQBiO95415.
PaxDbiO95415.
PeptideAtlasiO95415.
PRIDEiO95415.

Protocols and materials databases

DNASUi25798.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297290; ENSP00000297290; ENSG00000164713.
GeneIDi25798.
KEGGihsa:25798.
UCSCiuc003upi.3. human.

Organism-specific databases

CTDi25798.
DisGeNETi25798.
GeneCardsiBRI3.
HGNCiHGNC:1109. BRI3.
HPAiHPA042215.
MIMi615628. gene.
neXtProtiNX_O95415.
OpenTargetsiENSG00000164713.
PharmGKBiPA25422.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4517. Eukaryota.
ENOG41121JM. LUCA.
GeneTreeiENSGT00510000048486.
HOGENOMiHOG000035090.
HOVERGENiHBG104957.
InParanoidiO95415.
OMAiNIHSRAV.
OrthoDBiEOG091G18Q7.
PhylomeDBiO95415.
TreeFamiTF329242.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164713-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiBRI3. human.
GenomeRNAii25798.
PROiO95415.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164713.
CleanExiHS_BRI3.
ExpressionAtlasiO95415. baseline and differential.
GenevisibleiO95415. HS.

Family and domain databases

InterProiIPR019317. Brain_I3.
[Graphical view]
PANTHERiPTHR13551. PTHR13551. 1 hit.
PfamiPF10164. DUF2367. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBRI3_HUMAN
AccessioniPrimary (citable) accession number: O95415
Secondary accession number(s): D6W5R8, Q8WV52, Q9UIC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.