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Protein

TGFB1-induced anti-apoptotic factor 1

Gene

TIAF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation.1 Publication

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:G66-32593-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
TGFB1-induced anti-apoptotic factor 1
Alternative name(s):
12 kDa TGF-beta-1-induced antiapoptotic factor
Gene namesi
Name:TIAF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:11803. TIAF1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9220.
OpenTargetsiENSG00000221995.
PharmGKBiPA36512.

Polymorphism and mutation databases

BioMutaiTIAF1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725341 – 115TGFB1-induced anti-apoptotic factor 1Add BLAST115

Proteomic databases

PaxDbiO95411.
PRIDEiO95411.

Expressioni

Tissue specificityi

Not detectable in normal kidney and liver. Up-regulated in chronic and acute allograft rejection: expressed in the inflammatory infiltrate and in tubular epithelial cells.1 Publication

Gene expression databases

BgeeiENSG00000221995.
CleanExiHS_TIAF1.
GenevisibleiO95411. HS.

Organism-specific databases

HPAiHPA051129.

Interactioni

Protein-protein interaction databases

BioGridi114653. 2 interactors.
IntActiO95411. 1 interactor.
MINTiMINT-1134378.
STRINGi9606.ENSP00000352424.

Structurei

3D structure databases

ProteinModelPortaliO95411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410KCAK. Eukaryota.
ENOG4110P5V. LUCA.
GeneTreeiENSGT00650000095071.
HOVERGENiHBG079257.
InParanoidiO95411.
OMAiWVEQAYA.
OrthoDBiEOG091G0XL8.

Sequencei

Sequence statusi: Complete.

O95411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPSSPFRE QSFLCAAGDA GEESRVQVLK NEVRRGSPVL LGWVEQAYAD
60 70 80 90 100
KCVCGPSAPP APTPPSLSQR VMCNDLFKVN PFQLQQFRAD PSTASLLLCP
110
GGLDHKLNLR GKAWG
Length:115
Mass (Da):12,414
Last modified:August 31, 2004 - v2
Checksum:iC71C03671CBDB3B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49A → V in AAD04172 (PubMed:9918798).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105277 mRNA. Translation: AAD04172.1.
AC024619 Genomic DNA. No translation available.
CH471159 Genomic DNA. Translation: EAW51180.1.
BC047669 mRNA. Translation: AAH47669.1.
BC058075 mRNA. Translation: AAH58075.1.
BC131561 mRNA. Translation: AAI31562.1.
CCDSiCCDS32599.1.
RefSeqiNP_004731.2. NM_004740.3.
UniGeneiHs.462590.
Hs.743384.

Genome annotation databases

EnsembliENST00000359450; ENSP00000352424; ENSG00000221995.
GeneIDi9220.
KEGGihsa:9220.
UCSCiuc002hdv.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105277 mRNA. Translation: AAD04172.1.
AC024619 Genomic DNA. No translation available.
CH471159 Genomic DNA. Translation: EAW51180.1.
BC047669 mRNA. Translation: AAH47669.1.
BC058075 mRNA. Translation: AAH58075.1.
BC131561 mRNA. Translation: AAI31562.1.
CCDSiCCDS32599.1.
RefSeqiNP_004731.2. NM_004740.3.
UniGeneiHs.462590.
Hs.743384.

3D structure databases

ProteinModelPortaliO95411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114653. 2 interactors.
IntActiO95411. 1 interactor.
MINTiMINT-1134378.
STRINGi9606.ENSP00000352424.

Polymorphism and mutation databases

BioMutaiTIAF1.

Proteomic databases

PaxDbiO95411.
PRIDEiO95411.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359450; ENSP00000352424; ENSG00000221995.
GeneIDi9220.
KEGGihsa:9220.
UCSCiuc002hdv.2. human.

Organism-specific databases

CTDi9220.
DisGeNETi9220.
GeneCardsiTIAF1.
HGNCiHGNC:11803. TIAF1.
HPAiHPA051129.
MIMi609517. gene.
neXtProtiNX_O95411.
OpenTargetsiENSG00000221995.
PharmGKBiPA36512.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCAK. Eukaryota.
ENOG4110P5V. LUCA.
GeneTreeiENSGT00650000095071.
HOVERGENiHBG079257.
InParanoidiO95411.
OMAiWVEQAYA.
OrthoDBiEOG091G0XL8.

Enzyme and pathway databases

BioCyciZFISH:G66-32593-MONOMER.

Miscellaneous databases

GeneWikiiTIAF1.
GenomeRNAii9220.
PROiO95411.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000221995.
CleanExiHS_TIAF1.
GenevisibleiO95411. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiTIAF1_HUMAN
AccessioniPrimary (citable) accession number: O95411
Secondary accession number(s): A2RRE2, Q6PEG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 31, 2004
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The TIAF1 protein is coded in the 3'-UTR region of MYO18A. Does not seem to exist in orthologs.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.