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O95407

- TNF6B_HUMAN

UniProt

O95407 - TNF6B_HUMAN

Protein

Tumor necrosis factor receptor superfamily member 6B

Gene

TNFRSF6B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. receptor activity Source: ProtInc

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. negative regulation of apoptotic process Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor receptor superfamily member 6B
    Alternative name(s):
    Decoy receptor 3
    Short name:
    DcR3
    Decoy receptor for Fas ligand
    M68
    Gene namesi
    Name:TNFRSF6B
    Synonyms:DCR3, TR6
    ORF Names:UNQ186/PRO212
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:11921. TNFRSF6B.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36614.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 29291 PublicationAdd
    BLAST
    Chaini30 – 300271Tumor necrosis factor receptor superfamily member 6BPRO_0000034570Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 621 PublicationPROSITE-ProRule annotation
    Disulfide bondi52 ↔ 701 PublicationPROSITE-ProRule annotation
    Disulfide bondi73 ↔ 881 PublicationPROSITE-ProRule annotation
    Disulfide bondi91 ↔ 1051 PublicationPROSITE-ProRule annotation
    Disulfide bondi95 ↔ 1131 PublicationPROSITE-ProRule annotation
    Disulfide bondi115 ↔ 1261 PublicationPROSITE-ProRule annotation
    Disulfide bondi132 ↔ 1501 PublicationPROSITE-ProRule annotation
    Disulfide bondi153 ↔ 1681 PublicationPROSITE-ProRule annotation
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi174 ↔ 1931 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO95407.
    PRIDEiO95407.

    PTM databases

    PhosphoSiteiO95407.

    Expressioni

    Tissue specificityi

    Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

    Gene expression databases

    CleanExiHS_TNFRSF6B.
    GenevestigatoriO95407.

    Organism-specific databases

    HPAiHPA047154.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TNFSF14O435572EBI-524171,EBI-524131

    Protein-protein interaction databases

    BioGridi114301. 4 interactions.
    IntActiO95407. 2 interactions.
    STRINGi9606.ENSP00000359013.

    Structurei

    Secondary structure

    1
    300
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi35 – 395
    Turni41 – 433
    Beta strandi46 – 505
    Beta strandi56 – 605
    Beta strandi64 – 663
    Beta strandi69 – 724
    Beta strandi81 – 833
    Beta strandi99 – 1035
    Beta strandi107 – 1093
    Beta strandi112 – 1154
    Beta strandi119 – 1224
    Beta strandi125 – 1284
    Beta strandi136 – 1405
    Beta strandi144 – 1463
    Beta strandi149 – 1524
    Beta strandi163 – 1653
    Helixi174 – 1774
    Beta strandi181 – 1833
    Beta strandi186 – 1894
    Beta strandi191 – 1933

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3K51X-ray2.45B30-195[»]
    3MHDX-ray2.90D30-195[»]
    3MI8X-ray2.95D30-195[»]
    4J6GX-ray2.40C/D30-195[»]
    4KGGX-ray2.78C/D30-195[»]
    4KGQX-ray2.27C/D30-195[»]
    4MSVX-ray2.50B30-195[»]
    ProteinModelPortaliO95407.
    SMRiO95407. Positions 32-195.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO95407.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati31 – 7040TNFR-Cys 1Add
    BLAST
    Repeati72 – 11342TNFR-Cys 2Add
    BLAST
    Repeati115 – 15036TNFR-Cys 3Add
    BLAST
    Repeati152 – 19342TNFR-Cys 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG295608.
    HOGENOMiHOG000154657.
    KOiK05143.
    OMAiNVICGER.
    OrthoDBiEOG786H2Q.
    TreeFamiTF331157.

    Family and domain databases

    InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
    [Graphical view]
    PfamiPF00020. TNFR_c6. 1 hit.
    [Graphical view]
    SMARTiSM00208. TNFR. 4 hits.
    [Graphical view]
    PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
    PS50050. TNFR_NGFR_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O95407-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRALEGPGLS LLCLVLALPA LLPVPAVRGV AETPTYPWRD AETGERLVCA    50
    QCPPGTFVQR PCRRDSPTTC GPCPPRHYTQ FWNYLERCRY CNVLCGEREE 100
    EARACHATHN RACRCRTGFF AHAGFCLEHA SCPPGAGVIA PGTPSQNTQC 150
    QPCPPGTFSA SSSSSEQCQP HRNCTALGLA LNVPGSSSHD TLCTSCTGFP 200
    LSTRVPGAEE CERAVIDFVA FQDISIKRLQ RLLQALEAPE GWGPTPRAGR 250
    AALQLKLRRR LTELLGAQDG ALLVRLLQAL RVARMPGLER SVRERFLPVH 300
    Length:300
    Mass (Da):32,680
    Last modified:May 1, 1999 - v1
    Checksum:iF90AEE33718449AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF104419 mRNA. Translation: AAD03056.1.
    AF134240 mRNA. Translation: AAD29688.1.
    AF217796 Genomic DNA. Translation: AAF35244.1.
    AF217793 mRNA. Translation: AAF33685.1.
    AF217794 mRNA. Translation: AAF33686.1.
    AY358279 mRNA. Translation: AAQ88646.1.
    AL121845 Genomic DNA. Translation: CAC03668.1.
    BC017065 mRNA. Translation: AAH17065.1.
    BC034349 mRNA. Translation: AAH34349.1.
    CCDSiCCDS13532.1.
    RefSeqiNP_003814.1. NM_003823.3.
    UniGeneiHs.434878.

    Genome annotation databases

    GeneIDi8771.
    KEGGihsa:8771.
    UCSCiuc002yfy.3. human.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF104419 mRNA. Translation: AAD03056.1 .
    AF134240 mRNA. Translation: AAD29688.1 .
    AF217796 Genomic DNA. Translation: AAF35244.1 .
    AF217793 mRNA. Translation: AAF33685.1 .
    AF217794 mRNA. Translation: AAF33686.1 .
    AY358279 mRNA. Translation: AAQ88646.1 .
    AL121845 Genomic DNA. Translation: CAC03668.1 .
    BC017065 mRNA. Translation: AAH17065.1 .
    BC034349 mRNA. Translation: AAH34349.1 .
    CCDSi CCDS13532.1.
    RefSeqi NP_003814.1. NM_003823.3.
    UniGenei Hs.434878.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3K51 X-ray 2.45 B 30-195 [» ]
    3MHD X-ray 2.90 D 30-195 [» ]
    3MI8 X-ray 2.95 D 30-195 [» ]
    4J6G X-ray 2.40 C/D 30-195 [» ]
    4KGG X-ray 2.78 C/D 30-195 [» ]
    4KGQ X-ray 2.27 C/D 30-195 [» ]
    4MSV X-ray 2.50 B 30-195 [» ]
    ProteinModelPortali O95407.
    SMRi O95407. Positions 32-195.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114301. 4 interactions.
    IntActi O95407. 2 interactions.
    STRINGi 9606.ENSP00000359013.

    PTM databases

    PhosphoSitei O95407.

    Proteomic databases

    PaxDbi O95407.
    PRIDEi O95407.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8771.
    KEGGi hsa:8771.
    UCSCi uc002yfy.3. human.

    Organism-specific databases

    CTDi 8771.
    GeneCardsi GC20P062326.
    HGNCi HGNC:11921. TNFRSF6B.
    HPAi HPA047154.
    MIMi 603361. gene.
    neXtProti NX_O95407.
    PharmGKBi PA36614.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG295608.
    HOGENOMi HOG000154657.
    KOi K05143.
    OMAi NVICGER.
    OrthoDBi EOG786H2Q.
    TreeFami TF331157.

    Miscellaneous databases

    EvolutionaryTracei O95407.
    GeneWikii TNFRSF6B.
    GenomeRNAii 8771.
    NextBioi 32884.
    PROi O95407.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_TNFRSF6B.
    Genevestigatori O95407.

    Family and domain databases

    InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
    [Graphical view ]
    Pfami PF00020. TNFR_c6. 1 hit.
    [Graphical view ]
    SMARTi SM00208. TNFR. 4 hits.
    [Graphical view ]
    PROSITEi PS00652. TNFR_NGFR_1. 1 hit.
    PS50050. TNFR_NGFR_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal lung.
    2. "A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis."
      Yu K.-Y., Kwon B., Ni J., Zhai Y., Ebner R., Kwon B.S.
      J. Biol. Chem. 274:13733-13736(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 30-35.
      Tissue: Prostate.
    3. "Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster."
      Bai C., Connolly B., Metzker M.L., Hilliard C.A., Liu X., Sandig V., Soderman A., Galloway S.M., Liu Q., Austin C.P., Caskey C.T.
      Proc. Natl. Acad. Sci. U.S.A. 97:1230-1235(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Lung.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Skin.
    7. Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 30-195 IN COMPLEX WITH TNFSF15, FUNCTION, DISULFIDE BONDS.

    Entry informationi

    Entry nameiTNF6B_HUMAN
    AccessioniPrimary (citable) accession number: O95407
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3