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O95407 (TNF6B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor receptor superfamily member 6B
Alternative name(s):
Decoy receptor 3
Short name=DcR3
Decoy receptor for Fas ligand
M68
Gene names
Name:TNFRSF6B
Synonyms:DCR3, TR6
ORF Names:UNQ186/PRO212
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Ref.7

Subcellular location

Secreted.

Tissue specificity

Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Sequence similarities

Contains 4 TNFR-Cys repeats.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentSecreted
   DomainRepeat
Signal
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of apoptotic process

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentextracellular space

Non-traceable author statement Ref.2. Source: UniProtKB

   Molecular_functionprotein binding

Inferred from physical interaction Ref.2. Source: IntAct

receptor activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TNFSF14O435572EBI-524171,EBI-524131

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Ref.2
Chain30 – 300271Tumor necrosis factor receptor superfamily member 6B
PRO_0000034570

Regions

Repeat31 – 7040TNFR-Cys 1
Repeat72 – 11342TNFR-Cys 2
Repeat115 – 15036TNFR-Cys 3
Repeat152 – 19342TNFR-Cys 4

Amino acid modifications

Glycosylation1731N-linked (GlcNAc...) Potential
Disulfide bond49 ↔ 62 Ref.7
Disulfide bond52 ↔ 70 Ref.7
Disulfide bond73 ↔ 88 Ref.7
Disulfide bond91 ↔ 105 Ref.7
Disulfide bond95 ↔ 113 Ref.7
Disulfide bond115 ↔ 126 Ref.7
Disulfide bond132 ↔ 150 Ref.7
Disulfide bond153 ↔ 168 Ref.7
Disulfide bond174 ↔ 193 Ref.7

Secondary structure

......................................... 300
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O95407 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: F90AEE33718449AF

FASTA30032,680
        10         20         30         40         50         60 
MRALEGPGLS LLCLVLALPA LLPVPAVRGV AETPTYPWRD AETGERLVCA QCPPGTFVQR 

        70         80         90        100        110        120 
PCRRDSPTTC GPCPPRHYTQ FWNYLERCRY CNVLCGEREE EARACHATHN RACRCRTGFF 

       130        140        150        160        170        180 
AHAGFCLEHA SCPPGAGVIA PGTPSQNTQC QPCPPGTFSA SSSSSEQCQP HRNCTALGLA 

       190        200        210        220        230        240 
LNVPGSSSHD TLCTSCTGFP LSTRVPGAEE CERAVIDFVA FQDISIKRLQ RLLQALEAPE 

       250        260        270        280        290        300 
GWGPTPRAGR AALQLKLRRR LTELLGAQDG ALLVRLLQAL RVARMPGLER SVRERFLPVH 

« Hide

References

« Hide 'large scale' references
[1]"Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer."
Pitti R.M., Marsters S.A., Lawrence D.A., Roy M., Kischkel F.C., Dowd P., Huang A., Donahue C.J., Sherwood S.W., Baldwin D.T., Godowski P.J., Wood W.I., Gurney A.L., Hillan K.J., Cohen R.L., Goddard A.D., Botstein D., Ashkenazi A.
Nature 396:699-703(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal lung.
[2]"A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis."
Yu K.-Y., Kwon B., Ni J., Zhai Y., Ebner R., Kwon B.S.
J. Biol. Chem. 274:13733-13736(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 30-35.
Tissue: Prostate.
[3]"Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster."
Bai C., Connolly B., Metzker M.L., Hilliard C.A., Liu X., Sandig V., Soderman A., Galloway S.M., Liu Q., Austin C.P., Caskey C.T.
Proc. Natl. Acad. Sci. U.S.A. 97:1230-1235(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Lung.
[4]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung and Skin.
[7]"Decoy strategies: the structure of TL1A:DcR3 complex."
Zhan C., Patskovsky Y., Yan Q., Li Z., Ramagopal U., Cheng H., Brenowitz M., Hui X., Nathenson S.G., Almo S.C.
Structure 19:162-171(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 30-195 IN COMPLEX WITH TNFSF15, FUNCTION, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF104419 mRNA. Translation: AAD03056.1.
AF134240 mRNA. Translation: AAD29688.1.
AF217796 Genomic DNA. Translation: AAF35244.1.
AF217793 mRNA. Translation: AAF33685.1.
AF217794 mRNA. Translation: AAF33686.1.
AY358279 mRNA. Translation: AAQ88646.1.
AL121845 Genomic DNA. Translation: CAC03668.1.
BC017065 mRNA. Translation: AAH17065.1.
BC034349 mRNA. Translation: AAH34349.1.
CCDSCCDS13532.1.
RefSeqNP_003814.1. NM_003823.3.
UniGeneHs.434878.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3K51X-ray2.45B30-195[»]
3MHDX-ray2.90D30-195[»]
3MI8X-ray2.95D30-195[»]
4J6GX-ray2.40C/D30-195[»]
4KGGX-ray2.78C/D30-195[»]
4KGQX-ray2.27C/D30-195[»]
4MSVX-ray2.50B30-195[»]
ProteinModelPortalO95407.
SMRO95407. Positions 32-195.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114301. 4 interactions.
IntActO95407. 2 interactions.
STRING9606.ENSP00000359013.

PTM databases

PhosphoSiteO95407.

Proteomic databases

PaxDbO95407.
PRIDEO95407.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369996; ENSP00000359013; ENSG00000243509.
GeneID8771.
KEGGhsa:8771.
UCSCuc002yfy.3. human.

Organism-specific databases

CTD8771.
GeneCardsGC20P062326.
HGNCHGNC:11921. TNFRSF6B.
HPAHPA047154.
MIM603361. gene.
neXtProtNX_O95407.
PharmGKBPA36614.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG295608.
HOGENOMHOG000154657.
KOK05143.
OMANVICGER.
OrthoDBEOG786H2Q.
TreeFamTF331157.

Gene expression databases

CleanExHS_TNFRSF6B.
GenevestigatorO95407.

Family and domain databases

InterProIPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamPF00020. TNFR_c6. 1 hit.
[Graphical view]
SMARTSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO95407.
GeneWikiTNFRSF6B.
GenomeRNAi8771.
NextBio32884.
PROO95407.
SOURCESearch...

Entry information

Entry nameTNF6B_HUMAN
AccessionPrimary (citable) accession number: O95407
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM