Reviewed, UniProtKB/Swiss-Prot O95407 (TNF6B_HUMAN)

Names and origin

Protein names

Recommended name:
    Tumor necrosis factor receptor superfamily member 6B
Alternative name(s):
    Decoy receptor for Fas ligand
    Decoy receptor 3
      Short name=DcR3
    M68

Gene names

Name:	TNFRSF6B
Synonyms:	DCR3, TR6
ORF Names:	UNQ186/PRO212

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Decoy receptor for the cytotoxic ligands TNFS14/LIGHT and TNFSF6/FASL. Protects against apoptosis.
Subcellular location	Secreted.
Tissue specificity	Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.
Sequence similarities	Contains 4 TNFR-Cys repeats.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Secreted
Domain	Repeat Signal
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	anti-apoptosis Ref.1 Traceable author statement. Source: ProtInc apoptosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell soluble fraction Ref.1 Traceable author statement. Source: ProtInc
Molecular function	protein binding Ref.2 Inferred from physical interaction. Source: IntAct receptor activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TNFSF14	O43557	1	EBI-524171,EBI-524131

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Ref.2
	Chain	30 – 300	271	Tumor necrosis factor receptor superfamily member 6B		PRO_0000034570
Regions
	Repeat	31 – 70	40	TNFR-Cys 1
	Repeat	72 – 113	42	TNFR-Cys 2
	Repeat	115 – 150	36	TNFR-Cys 3
	Repeat	152 – 193	42	TNFR-Cys 4
Amino acid modifications
	Glycosylation	173	1	N-linked (GlcNAc...) Potential
	Disulfide bond	49 ↔ 62		By similarity
	Disulfide bond	52 ↔ 70		By similarity
	Disulfide bond	73 ↔ 88		By similarity
	Disulfide bond	91 ↔ 105		By similarity
	Disulfide bond	95 ↔ 113		By similarity
	Disulfide bond	115 ↔ 126		By similarity
	Disulfide bond	132 ↔ 150		By similarity
	Disulfide bond	153 ↔ 168		By similarity
	Disulfide bond	174 ↔ 193		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O95407-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: F90AEE33718449AF	FASTA	300	32,680
	10 20 30 40 50 60 MRALEGPGLS LLCLVLALPA LLPVPAVRGV AETPTYPWRD AETGERLVCA QCPPGTFVQR 70 80 90 100 110 120 PCRRDSPTTC GPCPPRHYTQ FWNYLERCRY CNVLCGEREE EARACHATHN RACRCRTGFF 130 140 150 160 170 180 AHAGFCLEHA SCPPGAGVIA PGTPSQNTQC QPCPPGTFSA SSSSSEQCQP HRNCTALGLA 190 200 210 220 230 240 LNVPGSSSHD TLCTSCTGFP LSTRVPGAEE CERAVIDFVA FQDISIKRLQ RLLQALEAPE 250 260 270 280 290 300 GWGPTPRAGR AALQLKLRRR LTELLGAQDG ALLVRLLQAL RVARMPGLER SVRERFLPVH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer." Pitti R.M., Marsters S.A., Lawrence D.A., Roy M., Kischkel F.C., Dowd P., Huang A., Donahue C.J., Sherwood S.W., Baldwin D.T., Godowski P.J., Wood W.I., Gurney A.L., Hillan K.J., Cohen R.L., Goddard A.D., Botstein D., Ashkenazi A. Nature 396:699-703(1998) [PubMed: 9872321] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal lung.
[2]	"A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis." Yu K.-Y., Kwon B., Ni J., Zhai Y., Ebner R., Kwon B.S. J. Biol. Chem. 274:13733-13736(1999) [PubMed: 10318773] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 30-35. Tissue: Prostate.
[3]	"Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster." Bai C., Connolly B., Metzker M.L., Hilliard C.A., Liu X., Sandig V., Soderman A., Galloway S.M., Liu Q., Austin C.P., Caskey C.T. Proc. Natl. Acad. Sci. U.S.A. 97:1230-1235(2000) [PubMed: 10655513] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Lung.
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Skin.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF104419 mRNA. Translation: AAD03056.1. AF134240 mRNA. Translation: AAD29688.1. AF217796 Genomic DNA. Translation: AAF35244.1. AF217793 mRNA. Translation: AAF33685.1. AF217794 mRNA. Translation: AAF33686.1. AY358279 mRNA. Translation: AAQ88646.1. AL121845 Genomic DNA. Translation: CAC03668.1. BC017065 mRNA. Translation: AAH17065.1. BC034349 mRNA. Translation: AAH34349.1.
IPI	IPI00646641.
RefSeq	NP_003814.1. NP_116563.1.
UniGene	Hs.434878
3D structure databases
HSSP	HSSP built from PDB template 1DU3 based on UniProtKB O14763.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95407. 1 interaction.
Proteomic databases
PRIDE	O95407.
Genome annotation databases
Ensembl	ENSG00000026036. Homo sapiens. [Contig view]
GeneID	8771.
KEGG	hsa:8771.
Organism-specific databases
GeneCards	GC20P061761.
H-InvDB	HIX0016007.
HGNC	HGNC:11921. TNFRSF6B.
MIM	603361. gene.
PharmGKB	PA36614.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	O95407.
OMA	O95407. QPHRNCT.
Gene expression databases
ArrayExpress	O95407.
Bgee	O95407.
CleanEx	HS_TNFRSF6B.
GermOnline	ENSG00000026036. Homo sapiens.
Family and domain databases
InterPro	IPR001368. TNFR_Cys_rich_reg. [Graphical view]
Pfam	PF00020. TNFR_c6. 2 hits. [Graphical view]
SMART	SM00208. TNFR. 4 hits. [Graphical view]
PROSITE	PS00652. TNFR_NGFR_1. 1 hit. PS50050. TNFR_NGFR_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	32884.
SOURCE	Search...

Entry information

Entry name

TNF6B_HUMAN

Accession

Primary (citable) accession number: O95407

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)