Reviewed,
UniProtKB/Swiss-Prot O95407 (TNF6B_HUMAN)
Last modified
June 16, 2009.
Version 71.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tumor necrosis factor receptor superfamily member 6B Alternative name(s): Decoy receptor for Fas ligand Decoy receptor 3 Short name=DcR3 M68 | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 300 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Decoy receptor for the cytotoxic ligands TNFS14/LIGHT and TNFSF6/FASL. Protects against apoptosis. |
| Subcellular location | |
| Tissue specificity | Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells. |
| Sequence similarities | Contains 4 TNFR-Cys repeats. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Apoptosis |
| Cellular component | Secreted |
| Domain | Repeat Signal |
| Molecular function | Receptor |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | anti-apoptosis Ref.1 Traceable author statement. Source: ProtInc apoptosisInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell soluble fraction Ref.1Traceable author statement. Source: ProtInc |
| Molecular function | protein binding Ref.2 Inferred from physical interaction. Source: IntAct receptor activity Ref.1Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 29 | 29 | Ref.2 | ||||||||
| Chain | 30 – 300 | 271 | Tumor necrosis factor receptor superfamily member 6B | PRO_0000034570 | |||||||
Regions | |||||||||||
| Repeat | 31 – 70 | 40 | TNFR-Cys 1 | ||||||||
| Repeat | 72 – 113 | 42 | TNFR-Cys 2 | ||||||||
| Repeat | 115 – 150 | 36 | TNFR-Cys 3 | ||||||||
| Repeat | 152 – 193 | 42 | TNFR-Cys 4 | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 173 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 49 ↔ 62 | By similarity | |||||||||
| Disulfide bond | 52 ↔ 70 | By similarity | |||||||||
| Disulfide bond | 73 ↔ 88 | By similarity | |||||||||
| Disulfide bond | 91 ↔ 105 | By similarity | |||||||||
| Disulfide bond | 95 ↔ 113 | By similarity | |||||||||
| Disulfide bond | 115 ↔ 126 | By similarity | |||||||||
| Disulfide bond | 132 ↔ 150 | By similarity | |||||||||
| Disulfide bond | 153 ↔ 168 | By similarity | |||||||||
| Disulfide bond | 174 ↔ 193 | By similarity | |||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer." Pitti R.M., Marsters S.A., Lawrence D.A., Roy M., Kischkel F.C., Dowd P., Huang A., Donahue C.J., Sherwood S.W., Baldwin D.T., Godowski P.J., Wood W.I., Gurney A.L., Hillan K.J., Cohen R.L., Goddard A.D., Botstein D., Ashkenazi A. Nature 396:699-703(1998) [PubMed: 9872321] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal lung. |
| [2] | "A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis." Yu K.-Y., Kwon B., Ni J., Zhai Y., Ebner R., Kwon B.S. J. Biol. Chem. 274:13733-13736(1999) [PubMed: 10318773] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 30-35. Tissue: Prostate. |
| [3] | "Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster." Bai C., Connolly B., Metzker M.L., Hilliard C.A., Liu X., Sandig V., Soderman A., Galloway S.M., Liu Q., Austin C.P., Caskey C.T. Proc. Natl. Acad. Sci. U.S.A. 97:1230-1235(2000) [PubMed: 10655513] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Lung. |
| [4] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. Rogers J.Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Skin. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF104419 mRNA. Translation: AAD03056.1. AF134240 mRNA. Translation: AAD29688.1. AF217796 Genomic DNA. Translation: AAF35244.1. AF217793 mRNA. Translation: AAF33685.1. AF217794 mRNA. Translation: AAF33686.1. AY358279 mRNA. Translation: AAQ88646.1. AL121845 Genomic DNA. Translation: CAC03668.1. BC017065 mRNA. Translation: AAH17065.1. BC034349 mRNA. Translation: AAH34349.1. | |
| IPI | IPI00646641. |
| RefSeq | NP_003814.1. NP_116563.1. |
| UniGene | Hs.434878 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1DU3 based on UniProtKB O14763. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O95407. 1 interaction. |
Proteomic databases | |
| PRIDE | O95407. |
Genome annotation databases | |
| Ensembl | ENSG00000026036. Homo sapiens. [Contig view] |
| GeneID | 8771. |
| KEGG | hsa:8771. |
Organism-specific databases | |
| GeneCards | GC20P061761. |
| H-InvDB | HIX0016007. |
| HGNC | HGNC:11921. TNFRSF6B. |
| MIM | 603361. gene. |
| PharmGKB | PA36614. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | O95407. |
| OMA | O95407. QPHRNCT. |
Gene expression databases | |
| ArrayExpress | O95407. |
| Bgee | O95407. |
| CleanEx | HS_TNFRSF6B. |
| GermOnline | ENSG00000026036. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001368. TNFR_Cys_rich_reg. [Graphical view] |
| Pfam | PF00020. TNFR_c6. 2 hits. [Graphical view] |
| SMART | SM00208. TNFR. 4 hits. [Graphical view] |
| PROSITE | PS00652. TNFR_NGFR_1. 1 hit. PS50050. TNFR_NGFR_2. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 32884. |
| SOURCE | Search... |
Entry information
| Entry name | TNF6B_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O95407 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 20 Human chromosome 20: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


