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Protein

Tumor necrosis factor receptor superfamily member 6B

Gene

TNFRSF6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.1 Publication

GO - Molecular functioni

  1. receptor activity Source: ProtInc

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. negative regulation of apoptotic process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 6B
Alternative name(s):
Decoy receptor 3
Short name:
DcR3
Decoy receptor for Fas ligand
M68
Gene namesi
Name:TNFRSF6B
Synonyms:DCR3, TR6
ORF Names:UNQ186/PRO212
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:11921. TNFRSF6B.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36614.

Polymorphism and mutation databases

BioMutaiTNFRSF6B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 29291 PublicationAdd
BLAST
Chaini30 – 300271Tumor necrosis factor receptor superfamily member 6BPRO_0000034570Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 62PROSITE-ProRule annotation1 Publication
Disulfide bondi52 ↔ 70PROSITE-ProRule annotation1 Publication
Disulfide bondi73 ↔ 88PROSITE-ProRule annotation1 Publication
Disulfide bondi91 ↔ 105PROSITE-ProRule annotation1 Publication
Disulfide bondi95 ↔ 113PROSITE-ProRule annotation1 Publication
Disulfide bondi115 ↔ 126PROSITE-ProRule annotation1 Publication
Disulfide bondi132 ↔ 150PROSITE-ProRule annotation1 Publication
Disulfide bondi153 ↔ 168PROSITE-ProRule annotation1 Publication
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi174 ↔ 193PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95407.
PRIDEiO95407.

PTM databases

PhosphoSiteiO95407.

Expressioni

Tissue specificityi

Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Gene expression databases

CleanExiHS_TNFRSF6B.
ExpressionAtlasiO95407. baseline.
GenevestigatoriO95407.

Organism-specific databases

HPAiHPA047154.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-9P604113EBI-524171,EBI-10172052
TNFSF14O435572EBI-524171,EBI-524131

Protein-protein interaction databases

BioGridi114301. 6 interactions.
IntActiO95407. 3 interactions.
STRINGi9606.ENSP00000359013.

Structurei

Secondary structure

1
300
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi35 – 395Combined sources
Turni41 – 433Combined sources
Beta strandi46 – 505Combined sources
Beta strandi56 – 605Combined sources
Beta strandi64 – 663Combined sources
Beta strandi69 – 724Combined sources
Beta strandi81 – 833Combined sources
Beta strandi99 – 1035Combined sources
Beta strandi107 – 1093Combined sources
Beta strandi112 – 1154Combined sources
Beta strandi119 – 1224Combined sources
Beta strandi125 – 1284Combined sources
Beta strandi136 – 1405Combined sources
Beta strandi144 – 1463Combined sources
Beta strandi149 – 1524Combined sources
Beta strandi163 – 1653Combined sources
Helixi174 – 1774Combined sources
Beta strandi181 – 1833Combined sources
Beta strandi186 – 1894Combined sources
Beta strandi191 – 1933Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3K51X-ray2.45B30-195[»]
3MHDX-ray2.90D30-195[»]
3MI8X-ray2.95D30-195[»]
4J6GX-ray2.40C/D30-195[»]
4KGGX-ray2.78C/D30-195[»]
4KGQX-ray2.27C/D30-195[»]
4MSVX-ray2.50B30-195[»]
ProteinModelPortaliO95407.
SMRiO95407. Positions 32-195.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95407.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati31 – 7040TNFR-Cys 1Add
BLAST
Repeati72 – 11342TNFR-Cys 2Add
BLAST
Repeati115 – 15036TNFR-Cys 3Add
BLAST
Repeati152 – 19342TNFR-Cys 4Add
BLAST

Sequence similaritiesi

Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG295608.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000154657.
InParanoidiO95407.
KOiK05143.
OMAiNVICGER.
OrthoDBiEOG786H2Q.
TreeFamiTF331157.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95407-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALEGPGLS LLCLVLALPA LLPVPAVRGV AETPTYPWRD AETGERLVCA
60 70 80 90 100
QCPPGTFVQR PCRRDSPTTC GPCPPRHYTQ FWNYLERCRY CNVLCGEREE
110 120 130 140 150
EARACHATHN RACRCRTGFF AHAGFCLEHA SCPPGAGVIA PGTPSQNTQC
160 170 180 190 200
QPCPPGTFSA SSSSSEQCQP HRNCTALGLA LNVPGSSSHD TLCTSCTGFP
210 220 230 240 250
LSTRVPGAEE CERAVIDFVA FQDISIKRLQ RLLQALEAPE GWGPTPRAGR
260 270 280 290 300
AALQLKLRRR LTELLGAQDG ALLVRLLQAL RVARMPGLER SVRERFLPVH
Length:300
Mass (Da):32,680
Last modified:May 1, 1999 - v1
Checksum:iF90AEE33718449AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104419 mRNA. Translation: AAD03056.1.
AF134240 mRNA. Translation: AAD29688.1.
AF217796 Genomic DNA. Translation: AAF35244.1.
AF217793 mRNA. Translation: AAF33685.1.
AF217794 mRNA. Translation: AAF33686.1.
AY358279 mRNA. Translation: AAQ88646.1.
AL121845 Genomic DNA. Translation: CAC03668.1.
BC017065 mRNA. Translation: AAH17065.1.
BC034349 mRNA. Translation: AAH34349.1.
CCDSiCCDS13532.1.
RefSeqiNP_003814.1. NM_003823.3.
UniGeneiHs.434878.

Genome annotation databases

EnsembliENST00000369996; ENSP00000359013; ENSG00000243509.
GeneIDi8771.
KEGGihsa:8771.
UCSCiuc002yfy.3. human.

Polymorphism and mutation databases

BioMutaiTNFRSF6B.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104419 mRNA. Translation: AAD03056.1.
AF134240 mRNA. Translation: AAD29688.1.
AF217796 Genomic DNA. Translation: AAF35244.1.
AF217793 mRNA. Translation: AAF33685.1.
AF217794 mRNA. Translation: AAF33686.1.
AY358279 mRNA. Translation: AAQ88646.1.
AL121845 Genomic DNA. Translation: CAC03668.1.
BC017065 mRNA. Translation: AAH17065.1.
BC034349 mRNA. Translation: AAH34349.1.
CCDSiCCDS13532.1.
RefSeqiNP_003814.1. NM_003823.3.
UniGeneiHs.434878.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3K51X-ray2.45B30-195[»]
3MHDX-ray2.90D30-195[»]
3MI8X-ray2.95D30-195[»]
4J6GX-ray2.40C/D30-195[»]
4KGGX-ray2.78C/D30-195[»]
4KGQX-ray2.27C/D30-195[»]
4MSVX-ray2.50B30-195[»]
ProteinModelPortaliO95407.
SMRiO95407. Positions 32-195.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114301. 6 interactions.
IntActiO95407. 3 interactions.
STRINGi9606.ENSP00000359013.

PTM databases

PhosphoSiteiO95407.

Polymorphism and mutation databases

BioMutaiTNFRSF6B.

Proteomic databases

PaxDbiO95407.
PRIDEiO95407.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369996; ENSP00000359013; ENSG00000243509.
GeneIDi8771.
KEGGihsa:8771.
UCSCiuc002yfy.3. human.

Organism-specific databases

CTDi8771.
GeneCardsiGC20P062326.
HGNCiHGNC:11921. TNFRSF6B.
HPAiHPA047154.
MIMi603361. gene.
neXtProtiNX_O95407.
PharmGKBiPA36614.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG295608.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000154657.
InParanoidiO95407.
KOiK05143.
OMAiNVICGER.
OrthoDBiEOG786H2Q.
TreeFamiTF331157.

Miscellaneous databases

EvolutionaryTraceiO95407.
GeneWikiiTNFRSF6B.
GenomeRNAii8771.
NextBioi32884.
PROiO95407.
SOURCEiSearch...

Gene expression databases

CleanExiHS_TNFRSF6B.
ExpressionAtlasiO95407. baseline.
GenevestigatoriO95407.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal lung.
  2. "A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis."
    Yu K.-Y., Kwon B., Ni J., Zhai Y., Ebner R., Kwon B.S.
    J. Biol. Chem. 274:13733-13736(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 30-35.
    Tissue: Prostate.
  3. "Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster."
    Bai C., Connolly B., Metzker M.L., Hilliard C.A., Liu X., Sandig V., Soderman A., Galloway S.M., Liu Q., Austin C.P., Caskey C.T.
    Proc. Natl. Acad. Sci. U.S.A. 97:1230-1235(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Lung.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Skin.
  7. Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 30-195 IN COMPLEX WITH TNFSF15, FUNCTION, DISULFIDE BONDS.

Entry informationi

Entry nameiTNF6B_HUMAN
AccessioniPrimary (citable) accession number: O95407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 1, 1999
Last modified: April 29, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.