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O95406

- CNIH1_HUMAN

UniProt

O95406 - CNIH1_HUMAN

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Protein

Protein cornichon homolog 1

Gene

CNIH1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the selective transport and maturation of TGF-alpha family proteins.1 Publication

GO - Biological processi

  1. immune response Source: ProtInc
  2. intracellular signal transduction Source: InterPro
  3. signal transduction Source: ProtInc
  4. vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cornichon homolog 1
Short name:
CNIH-1
Alternative name(s):
Cornichon family AMPA receptor auxiliary protein 1
Protein cornichon homolog
T-cell growth-associated molecule 77
Short name:
TGAM77
Gene namesi
Name:CNIH1
Synonyms:CNIH, CNIL
ORF Names:UNQ155/PRO181
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:19431. CNIH1.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication. Golgi apparatus membrane 1 Publication
Note: Located primarily in the ER; may cycle between the ER and the Golgi apparatus.

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. Golgi apparatus Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134864821.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 144144Protein cornichon homolog 1PRO_0000122222Add
BLAST

Proteomic databases

MaxQBiO95406.
PaxDbiO95406.
PeptideAtlasiO95406.
PRIDEiO95406.

Expressioni

Tissue specificityi

Highly expressed in heart, liver, skeletal muscle, pancreas, adrenal medulla and cortex, thyroid, testis, spleen, appendix, peripheral blood lymphocytes and bone marrow. Lower expression found in brain, placenta, lung, kidney, ovary, small intestine, stomach, lymph node, thymus and fetal liver. Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study).1 Publication

Gene expression databases

BgeeiO95406.
CleanExiHS_CNIH.
ExpressionAtlasiO95406. baseline and differential.
GenevestigatoriO95406.

Organism-specific databases

HPAiHPA002544.

Interactioni

Subunit structurei

Interacts with AREG immature precursor and with immature TGFA, i.e. with a prosegment and lacking full N-glycosylation, but not with the fully N-glycosylated form. In the Golgi apparatus, may form a complex with GORASP55 and transmembrane TGFA.1 Publication

Protein-protein interaction databases

BioGridi115476. 1 interaction.
STRINGi9606.ENSP00000216416.

Structurei

3D structure databases

ProteinModelPortaliO95406.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Topological domaini32 – 5625LumenalSequence AnalysisAdd
BLAST
Topological domaini78 – 12245CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini144 – 1441LumenalSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Transmembranei57 – 7721HelicalSequence AnalysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the cornichon family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG285570.
GeneTreeiENSGT00390000015751.
HOGENOMiHOG000214661.
HOVERGENiHBG003814.
InParanoidiO95406.
PhylomeDBiO95406.
TreeFamiTF300083.

Family and domain databases

InterProiIPR003377. Cornichon.
[Graphical view]
PfamiPF03311. Cornichon. 1 hit.
[Graphical view]
PROSITEiPS01340. CORNICHON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95406-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFTFAAFCY MLALLLTAAL IFFAIWHIIA FDELKTDYKN PIDQCNTLNP
60 70 80 90 100
LVLPEYLIHA FFCVMFLCAA EWLTLGLNMP LLAYHIWRYM SRPVMSGPGL
110 120 130 140
YDPTTIMNAD ILAYCQKEGW CKLAFYLLAF FYYLYGMIYV LVSS
Length:144
Mass (Da):16,699
Last modified:May 1, 1999 - v1
Checksum:i59BD114D24C455CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF104398 mRNA. Translation: AAC98388.1.
AF070654 mRNA. Translation: AAD20960.1.
AY358635 mRNA. Translation: AAQ88998.1.
AL359792 Genomic DNA. No translation available.
BC103741 mRNA. Translation: AAI03742.1.
AF031379 mRNA. Translation: AAD32301.1.
CCDSiCCDS9717.1.
RefSeqiNP_005767.1. NM_005776.2.
UniGeneiHs.294603.
Hs.594424.

Genome annotation databases

EnsembliENST00000216416; ENSP00000216416; ENSG00000100528.
GeneIDi10175.
KEGGihsa:10175.
UCSCiuc001xat.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF104398 mRNA. Translation: AAC98388.1 .
AF070654 mRNA. Translation: AAD20960.1 .
AY358635 mRNA. Translation: AAQ88998.1 .
AL359792 Genomic DNA. No translation available.
BC103741 mRNA. Translation: AAI03742.1 .
AF031379 mRNA. Translation: AAD32301.1 .
CCDSi CCDS9717.1.
RefSeqi NP_005767.1. NM_005776.2.
UniGenei Hs.294603.
Hs.594424.

3D structure databases

ProteinModelPortali O95406.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115476. 1 interaction.
STRINGi 9606.ENSP00000216416.

Proteomic databases

MaxQBi O95406.
PaxDbi O95406.
PeptideAtlasi O95406.
PRIDEi O95406.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000216416 ; ENSP00000216416 ; ENSG00000100528 .
GeneIDi 10175.
KEGGi hsa:10175.
UCSCi uc001xat.1. human.

Organism-specific databases

CTDi 10175.
GeneCardsi GC14M054894.
HGNCi HGNC:19431. CNIH1.
HPAi HPA002544.
MIMi 611287. gene.
neXtProti NX_O95406.
PharmGKBi PA134864821.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG285570.
GeneTreei ENSGT00390000015751.
HOGENOMi HOG000214661.
HOVERGENi HBG003814.
InParanoidi O95406.
PhylomeDBi O95406.
TreeFami TF300083.

Miscellaneous databases

ChiTaRSi CNIH. human.
GeneWikii CNIH.
GenomeRNAii 10175.
NextBioi 38526.
PROi O95406.
SOURCEi Search...

Gene expression databases

Bgeei O95406.
CleanExi HS_CNIH.
ExpressionAtlasi O95406. baseline and differential.
Genevestigatori O95406.

Family and domain databases

InterProi IPR003377. Cornichon.
[Graphical view ]
Pfami PF03311. Cornichon. 1 hit.
[Graphical view ]
PROSITEi PS01340. CORNICHON. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Plisov S.Y., Ivanov S.V., Lerman M., Perantoni A.O.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Carcinoma.
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  6. "The human homolog of Drosophila cornichon protein is differentially expressed in alloactivated T-cells."
    Utku N., Bulwin G.-C., Beinke S., Heinemann T., Beato F., Randall J., Schnieders B., Sandhoff K., Volk H.-D., Milford E., Gullans S.R.
    Biochim. Biophys. Acta 1449:203-210(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-144.
  7. "Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells."
    Perez Castro C., Piscopo D., Nakagawa T., Derynck R.
    J. Cell Sci. 120:2454-2466(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH AREG AND TGFA, SUBCELLULAR LOCATION.
  8. "Upregulation of cornichon transcripts in the dorsolateral prefrontal cortex in schizophrenia."
    Drummond J.B., Simmons M., Haroutunian V., Meador-Woodruff J.H.
    NeuroReport 23:1031-1034(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCNIH1_HUMAN
AccessioniPrimary (citable) accession number: O95406
Secondary accession number(s): Q3SYM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3