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O95406 (CNIH1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein cornichon homolog 1

Short name=CNIH-1
Alternative name(s):
Cornichon family AMPA receptor auxiliary protein 1
Protein cornichon homolog
T-cell growth-associated molecule 77
Short name=TGAM77
Gene names
Name:CNIH1
Synonyms:CNIH, CNIL
ORF Names:UNQ155/PRO181
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length144 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the selective transport and maturation of TGF-alpha family proteins. Ref.7

Subunit structure

Interacts with AREG immature precursor and with immature TGFA, i.e. with a prosegment and lacking full N-glycosylation, but not with the fully N-glycosylated form. In the Golgi apparatus, may form a complex with GORASP55 and transmembrane TGFA. Ref.7

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane. Note: Located primarily in the ER; may cycle between the ER and the Golgi apparatus. Ref.7

Tissue specificity

Highly expressed in heart, liver, skeletal muscle, pancreas, adrenal medulla and cortex, thyroid, testis, spleen, appendix, peripheral blood lymphocytes and bone marrow. Lower expression found in brain, placenta, lung, kidney, ovary, small intestine, stomach, lymph node, thymus and fetal liver. Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study). Ref.8

Sequence similarities

Belongs to the cornichon family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 144144Protein cornichon homolog 1
PRO_0000122222

Regions

Topological domain1 – 1010Cytoplasmic Potential
Transmembrane11 – 3121Helical; Potential
Topological domain32 – 5625Lumenal Potential
Transmembrane57 – 7721Helical; Potential
Topological domain78 – 12245Cytoplasmic Potential
Transmembrane123 – 14321Helical; Potential
Topological domain1441Lumenal Potential

Sequences

Sequence LengthMass (Da)Tools
O95406 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 59BD114D24C455CD

FASTA14416,699
        10         20         30         40         50         60 
MAFTFAAFCY MLALLLTAAL IFFAIWHIIA FDELKTDYKN PIDQCNTLNP LVLPEYLIHA 

        70         80         90        100        110        120 
FFCVMFLCAA EWLTLGLNMP LLAYHIWRYM SRPVMSGPGL YDPTTIMNAD ILAYCQKEGW 

       130        140 
CKLAFYLLAF FYYLYGMIYV LVSS 

« Hide

References

« Hide 'large scale' references
[1]Plisov S.Y., Ivanov S.V., Lerman M., Perantoni A.O.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Carcinoma.
[2]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Umbilical cord blood.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
[6]"The human homolog of Drosophila cornichon protein is differentially expressed in alloactivated T-cells."
Utku N., Bulwin G.-C., Beinke S., Heinemann T., Beato F., Randall J., Schnieders B., Sandhoff K., Volk H.-D., Milford E., Gullans S.R.
Biochim. Biophys. Acta 1449:203-210(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-144.
[7]"Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells."
Perez Castro C., Piscopo D., Nakagawa T., Derynck R.
J. Cell Sci. 120:2454-2466(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH AREG AND TGFA, SUBCELLULAR LOCATION.
[8]"Upregulation of cornichon transcripts in the dorsolateral prefrontal cortex in schizophrenia."
Drummond J.B., Simmons M., Haroutunian V., Meador-Woodruff J.H.
NeuroReport 23:1031-1034(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF104398 mRNA. Translation: AAC98388.1.
AF070654 mRNA. Translation: AAD20960.1.
AY358635 mRNA. Translation: AAQ88998.1.
AL359792 Genomic DNA. No translation available.
BC103741 mRNA. Translation: AAI03742.1.
AF031379 mRNA. Translation: AAD32301.1.
CCDSCCDS9717.1.
RefSeqNP_005767.1. NM_005776.2.
UniGeneHs.294603.
Hs.594424.

3D structure databases

ProteinModelPortalO95406.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115476. 1 interaction.
STRING9606.ENSP00000216416.

Proteomic databases

MaxQBO95406.
PaxDbO95406.
PeptideAtlasO95406.
PRIDEO95406.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000216416; ENSP00000216416; ENSG00000100528.
GeneID10175.
KEGGhsa:10175.
UCSCuc001xat.1. human.

Organism-specific databases

CTD10175.
GeneCardsGC14M054894.
HGNCHGNC:19431. CNIH1.
HPAHPA002544.
MIM611287. gene.
neXtProtNX_O95406.
PharmGKBPA134864821.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG285570.
HOGENOMHOG000214661.
HOVERGENHBG003814.
InParanoidO95406.
PhylomeDBO95406.
TreeFamTF300083.

Gene expression databases

ArrayExpressO95406.
BgeeO95406.
CleanExHS_CNIH.
GenevestigatorO95406.

Family and domain databases

InterProIPR003377. Cornichon.
[Graphical view]
PfamPF03311. Cornichon. 1 hit.
[Graphical view]
PROSITEPS01340. CORNICHON. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCNIH. human.
GeneWikiCNIH.
GenomeRNAi10175.
NextBio38526.
PROO95406.
SOURCESearch...

Entry information

Entry nameCNIH1_HUMAN
AccessionPrimary (citable) accession number: O95406
Secondary accession number(s): Q3SYM7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM