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Protein

Protein cornichon homolog 1

Gene

CNIH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the selective transport and maturation of TGF-alpha family proteins.1 Publication

GO - Biological processi

  • COPII vesicle coating Source: Reactome
  • ER to Golgi vesicle-mediated transport Source: Reactome
  • immune response Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-5694530. Cargo concentration in the ER.

Protein family/group databases

TCDBi8.A.61.1.2. the endoplasmic reticulum-derived vesicle protein, erv14 (erv14) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cornichon homolog 1
Short name:
CNIH-1
Alternative name(s):
Cornichon family AMPA receptor auxiliary protein 1
Protein cornichon homolog
T-cell growth-associated molecule 77
Short name:
TGAM77
Gene namesi
Name:CNIH1
Synonyms:CNIH, CNIL
ORF Names:UNQ155/PRO181
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19431. CNIH1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence analysis
Transmembranei11 – 3121HelicalSequence analysisAdd
BLAST
Topological domaini32 – 5625LumenalSequence analysisAdd
BLAST
Transmembranei57 – 7721HelicalSequence analysisAdd
BLAST
Topological domaini78 – 12245CytoplasmicSequence analysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence analysisAdd
BLAST
Topological domaini144 – 1441LumenalSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134864821.

Polymorphism and mutation databases

BioMutaiCNIH.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 144144Protein cornichon homolog 1PRO_0000122222Add
BLAST

Proteomic databases

MaxQBiO95406.
PaxDbiO95406.
PeptideAtlasiO95406.
PRIDEiO95406.

Expressioni

Tissue specificityi

Highly expressed in heart, liver, skeletal muscle, pancreas, adrenal medulla and cortex, thyroid, testis, spleen, appendix, peripheral blood lymphocytes and bone marrow. Lower expression found in brain, placenta, lung, kidney, ovary, small intestine, stomach, lymph node, thymus and fetal liver. Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study).1 Publication

Gene expression databases

BgeeiENSG00000100528.
CleanExiHS_CNIH.
ExpressionAtlasiO95406. baseline and differential.
GenevisibleiO95406. HS.

Organism-specific databases

HPAiHPA002544.

Interactioni

Subunit structurei

Interacts with AREG immature precursor and with immature TGFA, i.e. with a prosegment and lacking full N-glycosylation, but not with the fully N-glycosylated form. In the Golgi apparatus, may form a complex with GORASP55 and transmembrane TGFA.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000216416.

Structurei

3D structure databases

ProteinModelPortaliO95406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cornichon family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2729. Eukaryota.
ENOG4111MWH. LUCA.
GeneTreeiENSGT00390000015751.
HOGENOMiHOG000214661.
HOVERGENiHBG003814.
InParanoidiO95406.
PhylomeDBiO95406.
TreeFamiTF300083.

Family and domain databases

InterProiIPR003377. Cornichon.
IPR033466. Cornichon_conserved.
[Graphical view]
PfamiPF03311. Cornichon. 1 hit.
[Graphical view]
SMARTiSM01398. Cornichon. 1 hit.
[Graphical view]
PROSITEiPS01340. CORNICHON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFTFAAFCY MLALLLTAAL IFFAIWHIIA FDELKTDYKN PIDQCNTLNP
60 70 80 90 100
LVLPEYLIHA FFCVMFLCAA EWLTLGLNMP LLAYHIWRYM SRPVMSGPGL
110 120 130 140
YDPTTIMNAD ILAYCQKEGW CKLAFYLLAF FYYLYGMIYV LVSS
Length:144
Mass (Da):16,699
Last modified:May 1, 1999 - v1
Checksum:i59BD114D24C455CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104398 mRNA. Translation: AAC98388.1.
AF070654 mRNA. Translation: AAD20960.1.
AY358635 mRNA. Translation: AAQ88998.1.
AL359792 Genomic DNA. No translation available.
BC103741 mRNA. Translation: AAI03742.1.
AF031379 mRNA. Translation: AAD32301.1.
CCDSiCCDS9717.1.
RefSeqiNP_005767.1. NM_005776.2.
UniGeneiHs.294603.
Hs.594424.

Genome annotation databases

EnsembliENST00000216416; ENSP00000216416; ENSG00000100528.
GeneIDi10175.
KEGGihsa:10175.
UCSCiuc001xat.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104398 mRNA. Translation: AAC98388.1.
AF070654 mRNA. Translation: AAD20960.1.
AY358635 mRNA. Translation: AAQ88998.1.
AL359792 Genomic DNA. No translation available.
BC103741 mRNA. Translation: AAI03742.1.
AF031379 mRNA. Translation: AAD32301.1.
CCDSiCCDS9717.1.
RefSeqiNP_005767.1. NM_005776.2.
UniGeneiHs.294603.
Hs.594424.

3D structure databases

ProteinModelPortaliO95406.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000216416.

Protein family/group databases

TCDBi8.A.61.1.2. the endoplasmic reticulum-derived vesicle protein, erv14 (erv14) family.

Polymorphism and mutation databases

BioMutaiCNIH.

Proteomic databases

MaxQBiO95406.
PaxDbiO95406.
PeptideAtlasiO95406.
PRIDEiO95406.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216416; ENSP00000216416; ENSG00000100528.
GeneIDi10175.
KEGGihsa:10175.
UCSCiuc001xat.2. human.

Organism-specific databases

CTDi10175.
GeneCardsiCNIH1.
HGNCiHGNC:19431. CNIH1.
HPAiHPA002544.
MIMi611287. gene.
neXtProtiNX_O95406.
PharmGKBiPA134864821.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2729. Eukaryota.
ENOG4111MWH. LUCA.
GeneTreeiENSGT00390000015751.
HOGENOMiHOG000214661.
HOVERGENiHBG003814.
InParanoidiO95406.
PhylomeDBiO95406.
TreeFamiTF300083.

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-5694530. Cargo concentration in the ER.

Miscellaneous databases

GeneWikiiCNIH.
GenomeRNAii10175.
PROiO95406.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100528.
CleanExiHS_CNIH.
ExpressionAtlasiO95406. baseline and differential.
GenevisibleiO95406. HS.

Family and domain databases

InterProiIPR003377. Cornichon.
IPR033466. Cornichon_conserved.
[Graphical view]
PfamiPF03311. Cornichon. 1 hit.
[Graphical view]
SMARTiSM01398. Cornichon. 1 hit.
[Graphical view]
PROSITEiPS01340. CORNICHON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNIH1_HUMAN
AccessioniPrimary (citable) accession number: O95406
Secondary accession number(s): Q3SYM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.