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O95406

- CNIH1_HUMAN

UniProt

O95406 - CNIH1_HUMAN

Protein

Protein cornichon homolog 1

Gene

CNIH1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in the selective transport and maturation of TGF-alpha family proteins.1 Publication

    GO - Biological processi

    1. immune response Source: ProtInc
    2. intracellular signal transduction Source: InterPro
    3. signal transduction Source: ProtInc
    4. vesicle-mediated transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein cornichon homolog 1
    Short name:
    CNIH-1
    Alternative name(s):
    Cornichon family AMPA receptor auxiliary protein 1
    Protein cornichon homolog
    T-cell growth-associated molecule 77
    Short name:
    TGAM77
    Gene namesi
    Name:CNIH1
    Synonyms:CNIH, CNIL
    ORF Names:UNQ155/PRO181
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:19431. CNIH1.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication. Golgi apparatus membrane 1 Publication
    Note: Located primarily in the ER; may cycle between the ER and the Golgi apparatus.

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134864821.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 144144Protein cornichon homolog 1PRO_0000122222Add
    BLAST

    Proteomic databases

    MaxQBiO95406.
    PaxDbiO95406.
    PeptideAtlasiO95406.
    PRIDEiO95406.

    Expressioni

    Tissue specificityi

    Highly expressed in heart, liver, skeletal muscle, pancreas, adrenal medulla and cortex, thyroid, testis, spleen, appendix, peripheral blood lymphocytes and bone marrow. Lower expression found in brain, placenta, lung, kidney, ovary, small intestine, stomach, lymph node, thymus and fetal liver. Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study).1 Publication

    Gene expression databases

    ArrayExpressiO95406.
    BgeeiO95406.
    CleanExiHS_CNIH.
    GenevestigatoriO95406.

    Organism-specific databases

    HPAiHPA002544.

    Interactioni

    Subunit structurei

    Interacts with AREG immature precursor and with immature TGFA, i.e. with a prosegment and lacking full N-glycosylation, but not with the fully N-glycosylated form. In the Golgi apparatus, may form a complex with GORASP55 and transmembrane TGFA.1 Publication

    Protein-protein interaction databases

    BioGridi115476. 1 interaction.
    STRINGi9606.ENSP00000216416.

    Structurei

    3D structure databases

    ProteinModelPortaliO95406.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 5625LumenalSequence AnalysisAdd
    BLAST
    Topological domaini78 – 12245CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini144 – 1441LumenalSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei123 – 14321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cornichon family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG285570.
    HOGENOMiHOG000214661.
    HOVERGENiHBG003814.
    InParanoidiO95406.
    PhylomeDBiO95406.
    TreeFamiTF300083.

    Family and domain databases

    InterProiIPR003377. Cornichon.
    [Graphical view]
    PfamiPF03311. Cornichon. 1 hit.
    [Graphical view]
    PROSITEiPS01340. CORNICHON. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95406-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFTFAAFCY MLALLLTAAL IFFAIWHIIA FDELKTDYKN PIDQCNTLNP    50
    LVLPEYLIHA FFCVMFLCAA EWLTLGLNMP LLAYHIWRYM SRPVMSGPGL 100
    YDPTTIMNAD ILAYCQKEGW CKLAFYLLAF FYYLYGMIYV LVSS 144
    Length:144
    Mass (Da):16,699
    Last modified:May 1, 1999 - v1
    Checksum:i59BD114D24C455CD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF104398 mRNA. Translation: AAC98388.1.
    AF070654 mRNA. Translation: AAD20960.1.
    AY358635 mRNA. Translation: AAQ88998.1.
    AL359792 Genomic DNA. No translation available.
    BC103741 mRNA. Translation: AAI03742.1.
    AF031379 mRNA. Translation: AAD32301.1.
    CCDSiCCDS9717.1.
    RefSeqiNP_005767.1. NM_005776.2.
    UniGeneiHs.294603.
    Hs.594424.

    Genome annotation databases

    EnsembliENST00000216416; ENSP00000216416; ENSG00000100528.
    GeneIDi10175.
    KEGGihsa:10175.
    UCSCiuc001xat.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF104398 mRNA. Translation: AAC98388.1 .
    AF070654 mRNA. Translation: AAD20960.1 .
    AY358635 mRNA. Translation: AAQ88998.1 .
    AL359792 Genomic DNA. No translation available.
    BC103741 mRNA. Translation: AAI03742.1 .
    AF031379 mRNA. Translation: AAD32301.1 .
    CCDSi CCDS9717.1.
    RefSeqi NP_005767.1. NM_005776.2.
    UniGenei Hs.294603.
    Hs.594424.

    3D structure databases

    ProteinModelPortali O95406.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115476. 1 interaction.
    STRINGi 9606.ENSP00000216416.

    Proteomic databases

    MaxQBi O95406.
    PaxDbi O95406.
    PeptideAtlasi O95406.
    PRIDEi O95406.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216416 ; ENSP00000216416 ; ENSG00000100528 .
    GeneIDi 10175.
    KEGGi hsa:10175.
    UCSCi uc001xat.1. human.

    Organism-specific databases

    CTDi 10175.
    GeneCardsi GC14M054894.
    HGNCi HGNC:19431. CNIH1.
    HPAi HPA002544.
    MIMi 611287. gene.
    neXtProti NX_O95406.
    PharmGKBi PA134864821.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285570.
    HOGENOMi HOG000214661.
    HOVERGENi HBG003814.
    InParanoidi O95406.
    PhylomeDBi O95406.
    TreeFami TF300083.

    Miscellaneous databases

    ChiTaRSi CNIH. human.
    GeneWikii CNIH.
    GenomeRNAii 10175.
    NextBioi 38526.
    PROi O95406.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95406.
    Bgeei O95406.
    CleanExi HS_CNIH.
    Genevestigatori O95406.

    Family and domain databases

    InterProi IPR003377. Cornichon.
    [Graphical view ]
    Pfami PF03311. Cornichon. 1 hit.
    [Graphical view ]
    PROSITEi PS01340. CORNICHON. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Plisov S.Y., Ivanov S.V., Lerman M., Perantoni A.O.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Carcinoma.
    2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.
    6. "The human homolog of Drosophila cornichon protein is differentially expressed in alloactivated T-cells."
      Utku N., Bulwin G.-C., Beinke S., Heinemann T., Beato F., Randall J., Schnieders B., Sandhoff K., Volk H.-D., Milford E., Gullans S.R.
      Biochim. Biophys. Acta 1449:203-210(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-144.
    7. "Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells."
      Perez Castro C., Piscopo D., Nakagawa T., Derynck R.
      J. Cell Sci. 120:2454-2466(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH AREG AND TGFA, SUBCELLULAR LOCATION.
    8. "Upregulation of cornichon transcripts in the dorsolateral prefrontal cortex in schizophrenia."
      Drummond J.B., Simmons M., Haroutunian V., Meador-Woodruff J.H.
      NeuroReport 23:1031-1034(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCNIH1_HUMAN
    AccessioniPrimary (citable) accession number: O95406
    Secondary accession number(s): Q3SYM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3