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Protein

Protein cornichon homolog 1

Gene

CNIH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the selective transport and maturation of TGF-alpha family proteins.1 Publication

GO - Biological processi

  • COPII vesicle coating Source: Reactome
  • ER to Golgi vesicle-mediated transport Source: Reactome
  • immune response Source: ProtInc
  • signal transduction Source: ProtInc

Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-5694530 Cargo concentration in the ER

Protein family/group databases

TCDBi8.A.61.1.2 the endoplasmic reticulum-derived vesicle protein, erv14 (erv14) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cornichon homolog 1
Short name:
CNIH-1
Alternative name(s):
Cornichon family AMPA receptor auxiliary protein 1
Protein cornichon homolog
T-cell growth-associated molecule 77
Short name:
TGAM77
Gene namesi
Name:CNIH1
Synonyms:CNIH, CNIL
ORF Names:UNQ155/PRO181
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100528.11
HGNCiHGNC:19431 CNIH1
MIMi611287 gene
neXtProtiNX_O95406

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 56LumenalSequence analysisAdd BLAST25
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 122CytoplasmicSequence analysisAdd BLAST45
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144LumenalSequence analysis1

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100528
PharmGKBiPA134864821

Polymorphism and mutation databases

BioMutaiCNIH

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001222221 – 144Protein cornichon homolog 1Add BLAST144

Proteomic databases

MaxQBiO95406
PaxDbiO95406
PeptideAtlasiO95406
PRIDEiO95406

Expressioni

Tissue specificityi

Highly expressed in heart, liver, skeletal muscle, pancreas, adrenal medulla and cortex, thyroid, testis, spleen, appendix, peripheral blood lymphocytes and bone marrow. Lower expression found in brain, placenta, lung, kidney, ovary, small intestine, stomach, lymph node, thymus and fetal liver. Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study).1 Publication

Gene expression databases

BgeeiENSG00000100528
CleanExiHS_CNIH
ExpressionAtlasiO95406 baseline and differential
GenevisibleiO95406 HS

Organism-specific databases

HPAiHPA002544

Interactioni

Subunit structurei

Interacts with AREG immature precursor and with immature TGFA, i.e. with a prosegment and lacking full N-glycosylation, but not with the fully N-glycosylated form. In the Golgi apparatus, may form a complex with GORASP55 and transmembrane TGFA.1 Publication

Protein-protein interaction databases

BioGridi115476, 1 interactor
IntActiO95406, 7 interactors
STRINGi9606.ENSP00000216416

Structurei

3D structure databases

ProteinModelPortaliO95406
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cornichon family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2729 Eukaryota
ENOG4111MWH LUCA
GeneTreeiENSGT00390000015751
HOGENOMiHOG000214661
HOVERGENiHBG003814
InParanoidiO95406
KOiK20368
PhylomeDBiO95406
TreeFamiTF300083

Family and domain databases

InterProiView protein in InterPro
IPR003377 Cornichon
IPR033466 Cornichon_conserved
PfamiView protein in Pfam
PF03311 Cornichon, 1 hit
SMARTiView protein in SMART
SM01398 Cornichon, 1 hit
PROSITEiView protein in PROSITE
PS01340 CORNICHON, 1 hit

Sequencei

Sequence statusi: Complete.

O95406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFTFAAFCY MLALLLTAAL IFFAIWHIIA FDELKTDYKN PIDQCNTLNP
60 70 80 90 100
LVLPEYLIHA FFCVMFLCAA EWLTLGLNMP LLAYHIWRYM SRPVMSGPGL
110 120 130 140
YDPTTIMNAD ILAYCQKEGW CKLAFYLLAF FYYLYGMIYV LVSS
Length:144
Mass (Da):16,699
Last modified:May 1, 1999 - v1
Checksum:i59BD114D24C455CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104398 mRNA Translation: AAC98388.1
AF070654 mRNA Translation: AAD20960.1
AY358635 mRNA Translation: AAQ88998.1
AL359792 Genomic DNA No translation available.
BC103741 mRNA Translation: AAI03742.1
AF031379 mRNA Translation: AAD32301.1
CCDSiCCDS9717.1
RefSeqiNP_005767.1, NM_005776.2
UniGeneiHs.294603
Hs.594424

Genome annotation databases

EnsembliENST00000216416; ENSP00000216416; ENSG00000100528
GeneIDi10175
KEGGihsa:10175
UCSCiuc001xat.2 human

Similar proteinsi

Entry informationi

Entry nameiCNIH1_HUMAN
AccessioniPrimary (citable) accession number: O95406
Secondary accession number(s): Q3SYM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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