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Protein

CD2 antigen cytoplasmic tail-binding protein 2

Gene

CD2BP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.1 Publication

GO - Molecular functioni

  • ribonucleoprotein complex binding Source: BHF-UCL

GO - Biological processi

  • mRNA splicing, via spliceosome Source: Reactome
  • negative regulation of phosphatase activity Source: UniProtKB
  • spliceosomal tri-snRNP complex assembly Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169217-MONOMER.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
CD2 antigen cytoplasmic tail-binding protein 2
Short name:
CD2 cytoplasmic domain-binding protein 2
Short name:
CD2 tail-binding protein 2
Alternative name(s):
U5 snRNP 52K protein
Short name:
U5-52K
Gene namesi
Name:CD2BP2
Synonyms:KIAA1178
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:1656. CD2BP2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nucleoplasm Source: BHF-UCL
  • nucleus Source: BHF-UCL
  • U5 snRNP Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169217.
PharmGKBiPA26209.

Polymorphism and mutation databases

BioMutaiCD2BP2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894371 – 341CD2 antigen cytoplasmic tail-binding protein 2Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44N6-acetyllysineBy similarity1
Modified residuei46PhosphoserineCombined sources1
Modified residuei49PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei195PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95400.
MaxQBiO95400.
PaxDbiO95400.
PeptideAtlasiO95400.
PRIDEiO95400.

PTM databases

iPTMnetiO95400.
PhosphoSitePlusiO95400.

Expressioni

Gene expression databases

BgeeiENSG00000169217.
CleanExiHS_CD2BP2.
ExpressionAtlasiO95400. baseline and differential.
GenevisibleiO95400. HS.

Organism-specific databases

HPAiHPA041508.
HPA061309.

Interactioni

Subunit structurei

Component of the U5 snRNP complex composed of the U5 snRNA and at least PRPF6, PRPF8, SNRNP200, EFTUD2, SNRNP40, DDX23, TXNL4A and CD2BP2. Interacts directly with TXNL4A and PRPF6. Interacts (via GYF domain) with CD2 (via Pro-rich sequence in the cytoplasmic domain). Interacts with PQBP1.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CD2P067293EBI-768015,EBI-3912464
PPP1CAP621362EBI-768015,EBI-357253
PPP1CCP368733EBI-768015,EBI-356283
PRPF6O949065EBI-768015,EBI-536755
SNRPBP14678-25EBI-768015,EBI-372475
TXNL4AP838762EBI-768015,EBI-746539

Protein-protein interaction databases

BioGridi115690. 80 interactors.
IntActiO95400. 24 interactors.
MINTiMINT-99472.
STRINGi9606.ENSP00000304903.

Structurei

Secondary structure

1341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi282 – 293Combined sources12
Beta strandi296 – 300Combined sources5
Helixi301 – 309Combined sources9
Beta strandi318 – 324Combined sources7
Helixi332 – 334Combined sources3
Helixi337 – 340Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GYFNMR-A280-341[»]
1L2ZNMR-A280-341[»]
1SYXX-ray2.34B/D/F262-341[»]
4BWSX-ray2.50C/F280-341[»]
ProteinModelPortaliO95400.
SMRiO95400.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95400.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini280 – 338GYFPROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Contains 1 GYF domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2950. Eukaryota.
ENOG4111KF5. LUCA.
GeneTreeiENSGT00390000012483.
HOGENOMiHOG000007061.
HOVERGENiHBG056920.
InParanoidiO95400.
KOiK13099.
OMAiTGNMDIY.
OrthoDBiEOG091G0MVR.
PhylomeDBiO95400.
TreeFamiTF313042.

Family and domain databases

CDDicd00072. GYF. 1 hit.
Gene3Di3.30.1490.40. 1 hit.
InterProiIPR003169. GYF.
[Graphical view]
PfamiPF02213. GYF. 1 hit.
[Graphical view]
SMARTiSM00444. GYF. 1 hit.
[Graphical view]
SUPFAMiSSF55277. SSF55277. 1 hit.
PROSITEiPS50829. GYF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95400-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKVTFQG VGDEEDEDEI IVPKKKLVDP VAGSGGPGSR FKGKHSLDSD
60 70 80 90 100
EEEDDDDGGS SKYDILASED VEGQEAATLP SEGGVRITPF NLQEEMEEGH
110 120 130 140 150
FDADGNYFLN RDAQIRDSWL DNIDWVKIRE RPPGQRQASD SEEEDSLGQT
160 170 180 190 200
SMSAQALLEG LLELLLPRET VAGALRRLGA RGGGKGRKGP GQPSSPQRLD
210 220 230 240 250
RLSGLADQMV ARGNLGVYQE TRERLAMRLK GLGCQTLGPH NPTPPPSLDM
260 270 280 290 300
FAEELAEEEL ETPTPTQRGE AESRGDGLVD VMWEYKWENT GDAELYGPFT
310 320 330 340
SAQMQTWVSE GYFPDGVYCR KLDPPGGQFY NSKRIDFDLY T
Length:341
Mass (Da):37,646
Last modified:May 1, 1999 - v1
Checksum:i8E9A7EE0C40474D5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050772231G → D.Corresponds to variant rs13330462dbSNPEnsembl.1
Natural variantiVAR_050773262T → I.Corresponds to variant rs34391305dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104222 mRNA. Translation: AAC84141.1.
AK315708 mRNA. Translation: BAG38069.1.
CH471192 Genomic DNA. Translation: EAW52260.1.
BC000495 mRNA. Translation: AAH00495.1.
BC001947 mRNA. Translation: AAH01947.1.
AB033004 mRNA. Translation: BAA86492.1.
CCDSiCCDS10675.1.
RefSeqiNP_001230575.1. NM_001243646.1.
NP_006101.1. NM_006110.2.
UniGeneiHs.202677.

Genome annotation databases

EnsembliENST00000305596; ENSP00000304903; ENSG00000169217.
ENST00000569466; ENSP00000456935; ENSG00000169217.
GeneIDi10421.
KEGGihsa:10421.
UCSCiuc002dxr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104222 mRNA. Translation: AAC84141.1.
AK315708 mRNA. Translation: BAG38069.1.
CH471192 Genomic DNA. Translation: EAW52260.1.
BC000495 mRNA. Translation: AAH00495.1.
BC001947 mRNA. Translation: AAH01947.1.
AB033004 mRNA. Translation: BAA86492.1.
CCDSiCCDS10675.1.
RefSeqiNP_001230575.1. NM_001243646.1.
NP_006101.1. NM_006110.2.
UniGeneiHs.202677.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GYFNMR-A280-341[»]
1L2ZNMR-A280-341[»]
1SYXX-ray2.34B/D/F262-341[»]
4BWSX-ray2.50C/F280-341[»]
ProteinModelPortaliO95400.
SMRiO95400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115690. 80 interactors.
IntActiO95400. 24 interactors.
MINTiMINT-99472.
STRINGi9606.ENSP00000304903.

PTM databases

iPTMnetiO95400.
PhosphoSitePlusiO95400.

Polymorphism and mutation databases

BioMutaiCD2BP2.

Proteomic databases

EPDiO95400.
MaxQBiO95400.
PaxDbiO95400.
PeptideAtlasiO95400.
PRIDEiO95400.

Protocols and materials databases

DNASUi10421.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305596; ENSP00000304903; ENSG00000169217.
ENST00000569466; ENSP00000456935; ENSG00000169217.
GeneIDi10421.
KEGGihsa:10421.
UCSCiuc002dxr.4. human.

Organism-specific databases

CTDi10421.
GeneCardsiCD2BP2.
HGNCiHGNC:1656. CD2BP2.
HPAiHPA041508.
HPA061309.
MIMi604470. gene.
neXtProtiNX_O95400.
OpenTargetsiENSG00000169217.
PharmGKBiPA26209.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2950. Eukaryota.
ENOG4111KF5. LUCA.
GeneTreeiENSGT00390000012483.
HOGENOMiHOG000007061.
HOVERGENiHBG056920.
InParanoidiO95400.
KOiK13099.
OMAiTGNMDIY.
OrthoDBiEOG091G0MVR.
PhylomeDBiO95400.
TreeFamiTF313042.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169217-MONOMER.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSiCD2BP2. human.
EvolutionaryTraceiO95400.
GeneWikiiCD2BP2.
GenomeRNAii10421.
PROiO95400.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169217.
CleanExiHS_CD2BP2.
ExpressionAtlasiO95400. baseline and differential.
GenevisibleiO95400. HS.

Family and domain databases

CDDicd00072. GYF. 1 hit.
Gene3Di3.30.1490.40. 1 hit.
InterProiIPR003169. GYF.
[Graphical view]
PfamiPF02213. GYF. 1 hit.
[Graphical view]
SMARTiSM00444. GYF. 1 hit.
[Graphical view]
SUPFAMiSSF55277. SSF55277. 1 hit.
PROSITEiPS50829. GYF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD2B2_HUMAN
AccessioniPrimary (citable) accession number: O95400
Secondary accession number(s): B2RDX2, Q9ULP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.