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Protein

CD2 antigen cytoplasmic tail-binding protein 2

Gene

CD2BP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.1 Publication

GO - Molecular functioni

  • ribonucleoprotein complex binding Source: BHF-UCL

GO - Biological processi

  • mRNA splicing, via spliceosome Source: Reactome
  • negative regulation of phosphatase activity Source: UniProtKB
  • spliceosomal tri-snRNP complex assembly Source: BHF-UCL

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
CD2 antigen cytoplasmic tail-binding protein 2
Short name:
CD2 cytoplasmic domain-binding protein 2
Short name:
CD2 tail-binding protein 2
Alternative name(s):
U5 snRNP 52K protein
Short name:
U5-52K
Gene namesi
Name:CD2BP2
Synonyms:KIAA1178
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000169217.8.
HGNCiHGNC:1656. CD2BP2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10421.
OpenTargetsiENSG00000169217.
PharmGKBiPA26209.

Polymorphism and mutation databases

BioMutaiCD2BP2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894371 – 341CD2 antigen cytoplasmic tail-binding protein 2Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki26Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei44N6-acetyllysineBy similarity1
Modified residuei46PhosphoserineCombined sources1
Modified residuei49PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei195PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO95400.
MaxQBiO95400.
PaxDbiO95400.
PeptideAtlasiO95400.
PRIDEiO95400.

PTM databases

iPTMnetiO95400.
PhosphoSitePlusiO95400.

Expressioni

Gene expression databases

BgeeiENSG00000169217.
CleanExiHS_CD2BP2.
ExpressionAtlasiO95400. baseline and differential.
GenevisibleiO95400. HS.

Organism-specific databases

HPAiHPA041508.
HPA061309.

Interactioni

Subunit structurei

Component of the U5 snRNP complex composed of the U5 snRNA and at least PRPF6, PRPF8, SNRNP200, EFTUD2, SNRNP40, DDX23, TXNL4A and CD2BP2. Interacts directly with TXNL4A and PRPF6. Interacts (via GYF domain) with CD2 (via Pro-rich sequence in the cytoplasmic domain). Interacts with PQBP1.6 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115690. 81 interactors.
CORUMiO95400.
ELMiO95400.
IntActiO95400. 67 interactors.
MINTiMINT-99472.
STRINGi9606.ENSP00000304903.

Structurei

Secondary structure

1341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi282 – 293Combined sources12
Beta strandi296 – 300Combined sources5
Helixi301 – 309Combined sources9
Beta strandi318 – 324Combined sources7
Helixi332 – 334Combined sources3
Helixi337 – 340Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GYFNMR-A280-341[»]
1L2ZNMR-A280-341[»]
1SYXX-ray2.34B/D/F262-341[»]
4BWSX-ray2.50C/F280-341[»]
ProteinModelPortaliO95400.
SMRiO95400.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95400.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini280 – 338GYFPROSITE-ProRule annotationAdd BLAST59

Phylogenomic databases

eggNOGiKOG2950. Eukaryota.
ENOG4111KF5. LUCA.
GeneTreeiENSGT00390000012483.
HOGENOMiHOG000007061.
HOVERGENiHBG056920.
InParanoidiO95400.
KOiK13099.
OMAiTGNMDIY.
OrthoDBiEOG091G0MVR.
PhylomeDBiO95400.
TreeFamiTF313042.

Family and domain databases

CDDicd00072. GYF. 1 hit.
Gene3Di3.30.1490.40. 1 hit.
InterProiView protein in InterPro
IPR003169. GYF.
IPR035445. GYF-like_domain.
PfamiView protein in Pfam
PF02213. GYF. 1 hit.
SMARTiView protein in SMART
SM00444. GYF. 1 hit.
SUPFAMiSSF55277. SSF55277. 1 hit.
PROSITEiView protein in PROSITE
PS50829. GYF. 1 hit.

Sequencei

Sequence statusi: Complete.

O95400-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKVTFQG VGDEEDEDEI IVPKKKLVDP VAGSGGPGSR FKGKHSLDSD
60 70 80 90 100
EEEDDDDGGS SKYDILASED VEGQEAATLP SEGGVRITPF NLQEEMEEGH
110 120 130 140 150
FDADGNYFLN RDAQIRDSWL DNIDWVKIRE RPPGQRQASD SEEEDSLGQT
160 170 180 190 200
SMSAQALLEG LLELLLPRET VAGALRRLGA RGGGKGRKGP GQPSSPQRLD
210 220 230 240 250
RLSGLADQMV ARGNLGVYQE TRERLAMRLK GLGCQTLGPH NPTPPPSLDM
260 270 280 290 300
FAEELAEEEL ETPTPTQRGE AESRGDGLVD VMWEYKWENT GDAELYGPFT
310 320 330 340
SAQMQTWVSE GYFPDGVYCR KLDPPGGQFY NSKRIDFDLY T
Length:341
Mass (Da):37,646
Last modified:May 1, 1999 - v1
Checksum:i8E9A7EE0C40474D5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050772231G → D. Corresponds to variant dbSNP:rs13330462Ensembl.1
Natural variantiVAR_050773262T → I. Corresponds to variant dbSNP:rs34391305Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104222 mRNA. Translation: AAC84141.1.
AK315708 mRNA. Translation: BAG38069.1.
CH471192 Genomic DNA. Translation: EAW52260.1.
BC000495 mRNA. Translation: AAH00495.1.
BC001947 mRNA. Translation: AAH01947.1.
AB033004 mRNA. Translation: BAA86492.1.
CCDSiCCDS10675.1.
RefSeqiNP_001230575.1. NM_001243646.1.
NP_006101.1. NM_006110.2.
UniGeneiHs.202677.

Genome annotation databases

EnsembliENST00000305596; ENSP00000304903; ENSG00000169217.
ENST00000569466; ENSP00000456935; ENSG00000169217.
GeneIDi10421.
KEGGihsa:10421.
UCSCiuc002dxr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCD2B2_HUMAN
AccessioniPrimary (citable) accession number: O95400
Secondary accession number(s): B2RDX2, Q9ULP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: May 1, 1999
Last modified: September 27, 2017
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references