ID   UTS2_HUMAN              Reviewed;         124 AA.
AC   O95399; Q5H8X7; Q6UXF6; Q9UKP7;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   27-MAR-2024, entry version 176.
DE   RecName: Full=Urotensin-2;
DE   AltName: Full=Urotensin II;
DE            Short=U-II;
DE            Short=UII;
DE   Flags: Precursor;
GN   Name=UTS2; ORFNames=UNQ525/PRO1068;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Spinal cord;
RX   PubMed=9861051; DOI=10.1073/pnas.95.26.15803;
RA   Coulouarn Y., Lihrmann I., Jegou S., Anouar Y., Tostivint H.,
RA   Beauvillain J.-C., Conlon J.M., Bern H.A., Vaudry H.;
RT   "Cloning of the cDNA encoding the urotensin II precursor in frog and human
RT   reveals intense expression of the urotensin II gene in motoneurons of the
RT   spinal cord.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:15803-15808(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX   PubMed=10499587; DOI=10.1038/45809;
RA   Ames R.S., Sarau H.M., Chambers J.K., Willette R.N., Aiyar N.V.,
RA   Romanic A.M., Louden C.S., Foley J.J., Sauermelch C.F., Coatney R.W.,
RA   Ao Z., Disa J., Holmes S.D., Stadel J.M., Martin J.D., Liu W.-S.,
RA   Glover G.I., Wilson S., McNulty D.E., Ellis C.E., Elshourbagy N.A.,
RA   Shabon U., Trill J.J., Hay D.W.P., Ohlstein E.H., Bergsma D.J.,
RA   Douglas S.A.;
RT   "Human urotensin-II is a potent vasoconstrictor and agonist for the orphan
RT   receptor GPR14.";
RL   Nature 401:282-286(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT THR-12.
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [5]
RP   PROTEIN SEQUENCE OF 21-35 (ISOFORM 1).
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally verified
RT   cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
CC   -!- FUNCTION: Highly potent vasoconstrictor.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O95399-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O95399-2; Sequence=VSP_013638;
CC   -!- TISSUE SPECIFICITY: Brain specific.
CC   -!- SIMILARITY: Belongs to the urotensin-2 family. {ECO:0000305}.
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DR   EMBL; AF104118; AAD13070.1; -; mRNA.
DR   EMBL; AF140630; AAD55577.1; -; mRNA.
DR   EMBL; AY358375; AAQ88741.1; -; mRNA.
DR   EMBL; Z98884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS90.1; -. [O95399-2]
DR   CCDS; CCDS91.1; -. [O95399-1]
DR   RefSeq; NP_006777.1; NM_006786.3. [O95399-1]
DR   RefSeq; NP_068835.1; NM_021995.2. [O95399-2]
DR   RefSeq; XP_011538839.1; XM_011540537.2. [O95399-2]
DR   RefSeq; XP_011538840.1; XM_011540538.1. [O95399-1]
DR   PDB; 6HVB; NMR; -; A=117-124.
DR   PDB; 6HVC; NMR; -; A=117-124.
DR   PDBsum; 6HVB; -.
DR   PDBsum; 6HVC; -.
DR   AlphaFoldDB; O95399; -.
DR   SMR; O95399; -.
DR   BioGRID; 116116; 15.
DR   IntAct; O95399; 4.
DR   STRING; 9606.ENSP00000054668; -.
DR   BindingDB; O95399; -.
DR   GlyGen; O95399; 1 site, 1 O-linked glycan (1 site).
DR   BioMuta; UTS2; -.
DR   EPD; O95399; -.
DR   jPOST; O95399; -.
DR   MassIVE; O95399; -.
DR   MaxQB; O95399; -.
DR   PeptideAtlas; O95399; -.
DR   ProteomicsDB; 50851; -. [O95399-1]
DR   ProteomicsDB; 50852; -. [O95399-2]
DR   Pumba; O95399; -.
DR   Antibodypedia; 1351; 275 antibodies from 26 providers.
DR   DNASU; 10911; -.
DR   Ensembl; ENST00000054668.5; ENSP00000054668.5; ENSG00000049247.14. [O95399-2]
DR   Ensembl; ENST00000361696.10; ENSP00000355163.5; ENSG00000049247.14. [O95399-1]
DR   GeneID; 10911; -.
DR   KEGG; hsa:10911; -.
DR   MANE-Select; ENST00000361696.10; ENSP00000355163.5; NM_006786.4; NP_006777.1.
DR   UCSC; uc001aor.4; human. [O95399-1]
DR   AGR; HGNC:12636; -.
DR   CTD; 10911; -.
DR   DisGeNET; 10911; -.
DR   GeneCards; UTS2; -.
DR   HGNC; HGNC:12636; UTS2.
DR   HPA; ENSG00000049247; Tissue enhanced (adrenal gland, brain).
DR   MIM; 604097; gene.
DR   neXtProt; NX_O95399; -.
DR   OpenTargets; ENSG00000049247; -.
DR   PharmGKB; PA37261; -.
DR   VEuPathDB; HostDB:ENSG00000049247; -.
DR   GeneTree; ENSGT00510000049583; -.
DR   HOGENOM; CLU_156959_0_0_1; -.
DR   InParanoid; O95399; -.
DR   OMA; ETFYGNH; -.
DR   OrthoDB; 4340531at2759; -.
DR   PhylomeDB; O95399; -.
DR   TreeFam; TF330799; -.
DR   PathwayCommons; O95399; -.
DR   Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR   Reactome; R-HSA-416476; G alpha (q) signalling events.
DR   SignaLink; O95399; -.
DR   BioGRID-ORCS; 10911; 19 hits in 1143 CRISPR screens.
DR   ChiTaRS; UTS2; human.
DR   GeneWiki; UTS2; -.
DR   GenomeRNAi; 10911; -.
DR   Pharos; O95399; Tbio.
DR   PRO; PR:O95399; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; O95399; Protein.
DR   Bgee; ENSG00000049247; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 125 other cell types or tissues.
DR   ExpressionAtlas; O95399; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0005179; F:hormone activity; TAS:ProtInc.
DR   GO; GO:0005102; F:signaling receptor binding; TAS:ProtInc.
DR   GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; TAS:ProtInc.
DR   GO; GO:0006936; P:muscle contraction; TAS:ProtInc.
DR   GO; GO:0008217; P:regulation of blood pressure; IBA:GO_Central.
DR   InterPro; IPR001483; Urotensin_II.
DR   PANTHER; PTHR14447; UROTENSIN 2; 1.
DR   PANTHER; PTHR14447:SF0; UROTENSIN-2; 1.
DR   Pfam; PF02083; Urotensin_II; 1.
DR   PROSITE; PS00984; UROTENSIN_II; 1.
DR   Genevisible; O95399; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Cleavage on pair of basic residues;
KW   Direct protein sequencing; Disulfide bond; Hormone; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT   PROPEP          21..110
FT                   /id="PRO_0000036346"
FT   PEPTIDE         114..124
FT                   /note="Urotensin-2"
FT                   /id="PRO_0000036347"
FT   DISULFID        118..123
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         1..27
FT                   /note="MYKLASCCLLFIGFLNPLLSLPLLDSR -> METNVFHLMLCVTSARTHKST
FT                   SLCFGHFNSYPSLPLIHDLLL (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:10499587"
FT                   /id="VSP_013638"
FT   VARIANT         12
FT                   /note="I -> T (in dbSNP:rs34305100)"
FT                   /evidence="ECO:0000269|PubMed:12975309"
FT                   /id="VAR_053734"
FT   VARIANT         74
FT                   /note="S -> N (in dbSNP:rs2890565)"
FT                   /id="VAR_029313"
SQ   SEQUENCE   124 AA;  14296 MW;  C7A5FC7EFE00D312 CRC64;
     MYKLASCCLL FIGFLNPLLS LPLLDSREIS FQLSAPHEDA RLTPEELERA SLLQILPEML
     GAERGDILRK ADSSTNIFNP RGNLRKFQDF SGQDPNILLS HLLARIWKPY KKRETPDCFW
     KYCV
//