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Protein

Rap guanine nucleotide exchange factor 3

Gene

RAPGEF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi245 – 363cAMPAdd BLAST119

GO - Molecular functioni

  • cAMP binding Source: UniProtKB-KW
  • guanyl-nucleotide exchange factor activity Source: Reactome
  • protein domain specific binding Source: UniProtKB
  • Rap guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • cAMP-mediated signaling Source: BHF-UCL
  • cell proliferation Source: ProtInc
  • cellular response to cAMP Source: UniProtKB
  • establishment of endothelial barrier Source: UniProtKB
  • negative regulation of syncytium formation by plasma membrane fusion Source: UniProtKB
  • positive regulation of angiogenesis Source: UniProtKB
  • positive regulation of cAMP catabolic process Source: BHF-UCL
  • positive regulation of GTPase activity Source: UniProtKB
  • positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
  • positive regulation of protein acetylation Source: UniProtKB
  • positive regulation of protein export from nucleus Source: UniProtKB
  • positive regulation of stress fiber assembly Source: UniProtKB
  • positive regulation of syncytium formation by plasma membrane fusion Source: UniProtKB
  • Rap protein signal transduction Source: UniProtKB
  • regulation of actin cytoskeleton reorganization Source: UniProtKB
  • regulation of insulin secretion Source: Reactome
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Angiogenesis

Keywords - Ligandi

cAMP, cAMP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000079337-MONOMER.
ReactomeiR-HSA-354192. Integrin alphaIIb beta3 signaling.
R-HSA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-HSA-392517. Rap1 signalling.
R-HSA-422356. Regulation of insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
Rap guanine nucleotide exchange factor 3
Alternative name(s):
Exchange factor directly activated by cAMP 1
Exchange protein directly activated by cAMP 1
Short name:
EPAC 1
Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
cAMP-regulated guanine nucleotide exchange factor I
Short name:
cAMP-GEFI
Gene namesi
Name:RAPGEF3
Synonyms:CGEF1, EPAC, EPAC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:16629. RAPGEF3.

Subcellular locationi

GO - Cellular componenti

  • endomembrane system Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • filopodium Source: UniProtKB
  • intracellular Source: GOC
  • lamellipodium Source: UniProtKB
  • membrane Source: ProtInc
  • microvillus Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi315L → W: Abolishes activation of RAP1A. 1 Publication1
Mutagenesisi321R → K: Reduces activation of RAP1A. 1 Publication1
Mutagenesisi342F → A or T: Diminishes GEF activity dependence on cAMP concentration. 1 Publication1
Mutagenesisi412D → A: Abolishes interaction with PDE3B. 1 Publication1
Mutagenesisi415E → A: Abolishes interaction with PDE3B. 1 Publication1
Mutagenesisi417F → A: Abolishes interaction with PDE3B. 1 Publication1
Mutagenesisi420D → A: Abolishes interaction with PDE3B. 1 Publication1
Mutagenesisi421F → A: Abolishes interaction with PDE3B. 1 Publication1

Organism-specific databases

DisGeNETi10411.
OpenTargetsiENSG00000079337.
PharmGKBiPA134910959.

Chemistry databases

ChEMBLiCHEMBL2029197.
GuidetoPHARMACOLOGYi1292.

Polymorphism and mutation databases

BioMutaiRAPGEF3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000688671 – 923Rap guanine nucleotide exchange factor 3Add BLAST923

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei79PhosphoserineBy similarity1
Modified residuei528PhosphoserineBy similarity1
Modified residuei864PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO95398.
PaxDbiO95398.
PeptideAtlasiO95398.
PRIDEiO95398.

PTM databases

iPTMnetiO95398.
PhosphoSitePlusiO95398.

Expressioni

Tissue specificityi

Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.1 Publication

Gene expression databases

BgeeiENSG00000079337.
CleanExiHS_RAPGEF3.
ExpressionAtlasiO95398. baseline and differential.
GenevisibleiO95398. HS.

Organism-specific databases

HPAiCAB004386.
HPA040365.
HPA043518.

Interactioni

Subunit structurei

Interacts with PDE3B.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PDE3BQ133708EBI-6172806,EBI-6172856

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115682. 9 interactors.
IntActiO95398. 3 interactors.
MINTiMINT-6741771.
STRINGi9606.ENSP00000373864.

Chemistry databases

BindingDBiO95398.

Structurei

3D structure databases

ProteinModelPortaliO95398.
SMRiO95398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 186DEPPROSITE-ProRule annotationAdd BLAST77
Domaini384 – 518N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST135
Domaini662 – 889Ras-GEFPROSITE-ProRule annotationAdd BLAST228

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni218 – 242Interaction with PDE3B1 PublicationAdd BLAST25
Regioni398 – 422Interaction with PDE3B1 PublicationAdd BLAST25

Domaini

The DEP domain is involved in membrane localization independent from regulation by cAMP.1 Publication

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2378. Eukaryota.
ENOG410XPX9. LUCA.
GeneTreeiENSGT00860000133664.
HOGENOMiHOG000230545.
InParanoidiO95398.
KOiK08014.
OMAiWVATELC.
OrthoDBiEOG091G0HKG.
PhylomeDBiO95398.
TreeFamiTF313184.

Family and domain databases

CDDicd00155. RasGEF. 1 hit.
cd06224. REM. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.10.840.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR000591. DEP_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR014710. RmlC-like_jellyroll.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00610. DEP. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
SM00049. DEP. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48366. SSF48366. 3 hits.
SSF51206. SSF51206. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50186. DEP. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95398-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVGWPGESC WQVGLAVEDS PALGAPRVGA LPDVVPEGTL LNMVLRRMHR
60 70 80 90 100
PRSCSYQLLL EHQRPSCIQG LRWTPLTNSE ESLDFSESLE QASTERVLRA
110 120 130 140 150
GRQLHRHLLA TCPNLIRDRK YHLRLYRQCC SGRELVDGIL ALGLGVHSRS
160 170 180 190 200
QVVGICQVLL DEGALCHVKH DWAFQDRDAQ FYRFPGPEPE PVRTHEMEEE
210 220 230 240 250
LAEAVALLSQ RGPDALLTVA LRKPPGQRTD EELDLIFEEL LHIKAVAHLS
260 270 280 290 300
NSVKRELAAV LLFEPHSKAG TVLFSQGDKG TSWYIIWKGS VNVVTHGKGL
310 320 330 340 350
VTTLHEGDDF GQLALVNDAP RAATIILRED NCHFLRVDKQ DFNRIIKDVE
360 370 380 390 400
AKTMRLEEHG KVVLVLERAS QGAGPSRPPT PGRNRYTVMS GTPEKILELL
410 420 430 440 450
LEAMGPDSSA HDPTETFLSD FLLTHRVFMP SAQLCAALLH HFHVEPAGGS
460 470 480 490 500
EQERSTYVCN KRQQILRLVS QWVALYGSML HTDPVATSFL QKLSDLVGRD
510 520 530 540 550
TRLSNLLREQ WPERRRCHRL ENGCGNASPQ MKARNLPVWL PNQDEPLPGS
560 570 580 590 600
SCAIQVGDKV PYDICRPDHS VLTLQLPVTA SVREVMAALA QEDGWTKGQV
610 620 630 640 650
LVKVNSAGDA IGLQPDARGV ATSLGLNERL FVVNPQEVHE LIPHPDQLGP
660 670 680 690 700
TVGSAEGLDL VSAKDLAGQL TDHDWSLFNS IHQVELIHYV LGPQHLRDVT
710 720 730 740 750
TANLERFMRR FNELQYWVAT ELCLCPVPGP RAQLLRKFIK LAAHLKEQKN
760 770 780 790 800
LNSFFAVMFG LSNSAISRLA HTWERLPHKV RKLYSALERL LDPSWNHRVY
810 820 830 840 850
RLALAKLSPP VIPFMPLLLK DMTFIHEGNH TLVENLINFE KMRMMARAAR
860 870 880 890 900
MLHHCRSHNP VPLSPLRSRV SHLHEDSQVA RISTCSEQSL STRSPASTWA
910 920
YVQQLKVIDN QRELSRLSRE LEP
Length:923
Mass (Da):103,751
Last modified:January 11, 2011 - v6
Checksum:i8B3A24341F20515F
GO
Isoform 2 (identifier: O95398-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     533-598: ARNLPVWLPN...LAQEDGWTKG → VSAWPQFLSS...GQAVPGGAEA
     599-923: Missing.

Show »
Length:598
Mass (Da):66,067
Checksum:i8F67017CA93D36F8
GO
Isoform 3 (identifier: O95398-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Note: Gene prediction based on EST data.
Show »
Length:881
Mass (Da):99,452
Checksum:i67093C76C1830478
GO

Sequence cautioni

The sequence AAD02890 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAD12740 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64R → H in AAD12740 (PubMed:9856955).Curated1
Sequence conflicti64R → H in AAD02890 (PubMed:9856955).Curated1
Sequence conflicti106R → Q in AAD12740 (PubMed:9856955).Curated1
Sequence conflicti106R → Q in AAD02890 (PubMed:9856955).Curated1
Sequence conflicti116I → T in AAC83381 (PubMed:9853756).Curated1
Sequence conflicti330D → Y in AAD12740 (PubMed:9856955).Curated1
Sequence conflicti330D → Y in AAD02890 (PubMed:9856955).Curated1
Sequence conflicti394E → D in AAD12740 (PubMed:9856955).Curated1
Sequence conflicti394E → D in AAD02890 (PubMed:9856955).Curated1
Sequence conflicti406P → L in AAD12740 (PubMed:9856955).Curated1
Sequence conflicti406P → L in AAD02890 (PubMed:9856955).Curated1
Sequence conflicti414T → K in AAD12740 (PubMed:9856955).Curated1
Sequence conflicti414T → K in AAD02890 (PubMed:9856955).Curated1
Sequence conflicti491Q → H in AAD12740 (PubMed:9856955).Curated1
Sequence conflicti638V → A in AAC83381 (PubMed:9853756).Curated1
Sequence conflicti736R → K in AAD12740 (PubMed:9856955).Curated1
Sequence conflicti751L → V in AAD12740 (PubMed:9856955).Curated1
Sequence conflicti765A → P in AAD12740 (PubMed:9856955).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04792416A → P.1 PublicationCorresponds to variant rs11168230dbSNPEnsembl.1
Natural variantiVAR_047925193R → G.5 PublicationsCorresponds to variant rs2016123dbSNPEnsembl.1
Natural variantiVAR_047926374G → S.Corresponds to variant rs12422983dbSNPEnsembl.1
Natural variantiVAR_061784517C → Y.Corresponds to variant rs61709815dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0470071 – 42Missing in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_007608533 – 598ARNLP…GWTKG → VSAWPQFLSSAPPGLQAPPS PPDPEGLCGRGKLSSHRHTL GSLIGVHGALAACGALGQAV PGGAEA in isoform 2. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_007609599 – 923Missing in isoform 2. 1 PublicationAdd BLAST325

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78168 mRNA. Translation: AAD12740.1. Different initiation.
U78169 mRNA. Translation: AAD02890.1. Different initiation.
AK290230 mRNA. Translation: BAF82919.1.
AC004241 Genomic DNA. No translation available.
AC137054 Genomic DNA. No translation available.
CH471111 Genomic DNA. Translation: EAW57944.1.
BC017728 mRNA. Translation: AAH17728.2.
AF103905 mRNA. Translation: AAC83381.1.
CCDSiCCDS31784.1. [O95398-3]
CCDS41775.1. [O95398-1]
RefSeqiNP_001092002.1. NM_001098532.2.
NP_006096.2. NM_006105.5.
UniGeneiHs.8578.

Genome annotation databases

EnsembliENST00000389212; ENSP00000373864; ENSG00000079337. [O95398-1]
ENST00000395358; ENSP00000378764; ENSG00000079337. [O95398-2]
ENST00000405493; ENSP00000384521; ENSG00000079337. [O95398-3]
ENST00000449771; ENSP00000395708; ENSG00000079337. [O95398-1]
ENST00000549151; ENSP00000448619; ENSG00000079337. [O95398-3]
GeneIDi10411.
KEGGihsa:10411.
UCSCiuc001rpz.5. human. [O95398-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78168 mRNA. Translation: AAD12740.1. Different initiation.
U78169 mRNA. Translation: AAD02890.1. Different initiation.
AK290230 mRNA. Translation: BAF82919.1.
AC004241 Genomic DNA. No translation available.
AC137054 Genomic DNA. No translation available.
CH471111 Genomic DNA. Translation: EAW57944.1.
BC017728 mRNA. Translation: AAH17728.2.
AF103905 mRNA. Translation: AAC83381.1.
CCDSiCCDS31784.1. [O95398-3]
CCDS41775.1. [O95398-1]
RefSeqiNP_001092002.1. NM_001098532.2.
NP_006096.2. NM_006105.5.
UniGeneiHs.8578.

3D structure databases

ProteinModelPortaliO95398.
SMRiO95398.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115682. 9 interactors.
IntActiO95398. 3 interactors.
MINTiMINT-6741771.
STRINGi9606.ENSP00000373864.

Chemistry databases

BindingDBiO95398.
ChEMBLiCHEMBL2029197.
GuidetoPHARMACOLOGYi1292.

PTM databases

iPTMnetiO95398.
PhosphoSitePlusiO95398.

Polymorphism and mutation databases

BioMutaiRAPGEF3.

Proteomic databases

MaxQBiO95398.
PaxDbiO95398.
PeptideAtlasiO95398.
PRIDEiO95398.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389212; ENSP00000373864; ENSG00000079337. [O95398-1]
ENST00000395358; ENSP00000378764; ENSG00000079337. [O95398-2]
ENST00000405493; ENSP00000384521; ENSG00000079337. [O95398-3]
ENST00000449771; ENSP00000395708; ENSG00000079337. [O95398-1]
ENST00000549151; ENSP00000448619; ENSG00000079337. [O95398-3]
GeneIDi10411.
KEGGihsa:10411.
UCSCiuc001rpz.5. human. [O95398-1]

Organism-specific databases

CTDi10411.
DisGeNETi10411.
GeneCardsiRAPGEF3.
HGNCiHGNC:16629. RAPGEF3.
HPAiCAB004386.
HPA040365.
HPA043518.
MIMi606057. gene.
neXtProtiNX_O95398.
OpenTargetsiENSG00000079337.
PharmGKBiPA134910959.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2378. Eukaryota.
ENOG410XPX9. LUCA.
GeneTreeiENSGT00860000133664.
HOGENOMiHOG000230545.
InParanoidiO95398.
KOiK08014.
OMAiWVATELC.
OrthoDBiEOG091G0HKG.
PhylomeDBiO95398.
TreeFamiTF313184.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000079337-MONOMER.
ReactomeiR-HSA-354192. Integrin alphaIIb beta3 signaling.
R-HSA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-HSA-392517. Rap1 signalling.
R-HSA-422356. Regulation of insulin secretion.

Miscellaneous databases

ChiTaRSiRAPGEF3. human.
GeneWikiiRAPGEF3.
GenomeRNAii10411.
PROiO95398.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000079337.
CleanExiHS_RAPGEF3.
ExpressionAtlasiO95398. baseline and differential.
GenevisibleiO95398. HS.

Family and domain databases

CDDicd00155. RasGEF. 1 hit.
cd06224. REM. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.10.840.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR000591. DEP_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR014710. RmlC-like_jellyroll.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00610. DEP. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
SM00049. DEP. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48366. SSF48366. 3 hits.
SSF51206. SSF51206. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50186. DEP. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPGF3_HUMAN
AccessioniPrimary (citable) accession number: O95398
Secondary accession number(s): A8K2G5
, E7EQC8, O95634, Q8WVN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 157 of the entry and version 6 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-43 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.