O95393 (BMP10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bone morphogenetic protein 10
Short name=BMP-10

Gene names

Name:

BMP10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	424 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. Ref.4 Ref.5
Subunit structure	Homodimer; disulfide-linked By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the TGF-beta family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine Developmental protein Growth factor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	BMP signaling pathway Inferred from direct assay Ref.4Ref.5. Source: BHF-UCL activin receptor signaling pathway Inferred from direct assay Ref.4Ref.5. Source: BHF-UCL adult heart development Inferred from sequence or structural similarity PubMed 10072785. Source: BHF-UCL atrial cardiac muscle tissue morphogenesis Inferred from sequence or structural similarity PubMed 10072785. Source: BHF-UCL cardiac muscle cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB cardiac muscle hypertrophy in response to stress Inferred by curator PubMed 17921333. Source: BHF-UCL heart trabecula formation Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of cardiac muscle hypertrophy Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of cell growth Inferred from direct assay Ref.5. Source: UniProtKB negative regulation of endothelial cell migration Inferred from direct assay Ref.5. Source: BHF-UCL pathway-restricted SMAD protein phosphorylation Inferred from direct assay Ref.4Ref.5. Source: BHF-UCL positive regulation of cardiac muscle cell proliferation Inferred from sequence or structural similarity PubMed 10072785. Source: BHF-UCL positive regulation of cardiac muscle hypertrophy Inferred from mutant phenotype PubMed 17921333. Source: BHF-UCL positive regulation of cell proliferation involved in heart morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of pathway-restricted SMAD protein phosphorylation Inferred from direct assay Ref.4Ref.5PubMed 19903896. Source: BHF-UCL positive regulation of sarcomere organization Inferred from direct assay PubMed 17921333. Source: BHF-UCL positive regulation of transcription, DNA-dependent Inferred from direct assay Ref.4Ref.5. Source: BHF-UCL regulation of cardiac muscle contraction Inferred from mutant phenotype PubMed 17921333. Source: BHF-UCL sarcomere organization Inferred from sequence or structural similarity. Source: BHF-UCL ventricular cardiac muscle cell development Inferred from sequence or structural similarity PubMed 10072785. Source: BHF-UCL ventricular cardiac muscle tissue morphogenesis Inferred from sequence or structural similarity PubMed 10072785. Source: BHF-UCL
Cellular_component	Z disc Inferred from direct assay PubMed 17921333. Source: BHF-UCL cell surface Inferred from direct assay PubMed 17921333. Source: BHF-UCL extracellular space Inferred from direct assay PubMed 17921333. Source: BHF-UCL
Molecular_function	hormone activity Inferred from direct assay PubMed 17921333. Source: BHF-UCL receptor serine/threonine kinase binding Inferred from direct assay Ref.5. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Propeptide	22 – 316	295	Potential		PRO_0000033888
	Chain	317 – 424	108	Bone morphogenetic protein 10		PRO_0000033889
Amino acid modifications
	Glycosylation	67	1	N-linked (GlcNAc...) Potential
	Glycosylation	131	1	N-linked (GlcNAc...) Potential
	Disulfide bond	323 ↔ 389		By similarity
	Disulfide bond	352 ↔ 421		By similarity
	Disulfide bond	356 ↔ 423		By similarity
	Disulfide bond	388		Interchain By similarity
Natural variations
	Natural variant	200	1	T → S. Corresponds to variant rs2231342 [ dbSNP | Ensembl ].		VAR_052572
	Natural variant	250	1	N → K. Corresponds to variant rs2231345 [ dbSNP | Ensembl ].		VAR_052573
Experimental info
	Sequence conflict	143	1	A → T in AAH69080. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	O95393 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 3FDB3B7221BB2254	FASTA	424	48,047
	10 20 30 40 50 60 MGSLVLTLCA LFCLAAYLVS GSPIMNLEQS PLEEDMSLFG DVFSEQDGVD FNTLLQSMKD 70 80 90 100 110 120 EFLKTLNLSD IPTQDSAKVD PPEYMLELYN KFATDRTSMP SANIIRSFKN EDLFSQPVSF 130 140 150 160 170 180 NGLRKYPLLF NVSIPHHEEV IMAELRLYTL VQRDRMIYDG VDRKITIFEV LESKGDNEGE 190 200 210 220 230 240 RNMLVLVSGE IYGTNSEWET FDVTDAIRRW QKSGSSTHQL EVHIESKHDE AEDASSGRLE 250 260 270 280 290 300 IDTSAQNKHN PLLIVFSDDQ SSDKERKEEL NEMISHEQLP ELDNLGLDSF SSGPGEEALL 310 320 330 340 350 360 QMRSNIIYDS TARIRRNAKG NYCKRTPLYI DFKEIGWDSW IIAPPGYEAY ECRGVCNYPL 370 380 390 400 410 420 AEHLTPTKHA IIQALVHLKN SQKASKACCV PTKLEPISIL YLDKGVVTYK FKYEGMAVSE CGCR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homo sapiens bone morphogenetic protein 10 (BMP-10) mRNA." Celeste A.J. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum.
[4]	"Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses." Mazerbourg S., Sangkuhl K., Luo C.-W., Sudo S., Klein C., Hsueh A.J.W. J. Biol. Chem. 280:32122-32132(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[5]	"Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells." David L., Mallet C., Mazerbourg S., Feige J.-J., Bailly S. Blood 109:1953-1961(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Web resources

Wikipedia

Bone morphogenetic protein 10 entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF101441 mRNA. Translation: AAC77462.1. AC097495 Genomic DNA. Translation: AAY15075.1. BC069080 mRNA. Translation: AAH69080.1. BC101734 mRNA. Translation: AAI01735.1. BC105063 mRNA. Translation: AAI05064.1.
IPI	IPI00030115.
RefSeq	NP_055297.1. NM_014482.1.
UniGene	Hs.158317.
3D structure databases
ProteinModelPortal	O95393.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95393. 1 interaction.
STRING	9606.ENSP00000295379.
PTM databases
PhosphoSite	O95393.
Proteomic databases
PaxDb	O95393.
PRIDE	O95393.
Protocols and materials databases
DNASU	27302.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295379; ENSP00000295379; ENSG00000163217.
GeneID	27302.
KEGG	hsa:27302.
UCSC	uc002sez.1. human.
Organism-specific databases
CTD	27302.
GeneCards	GC02M069092.
HGNC	HGNC:20869. BMP10.
HPA	HPA010987.
MIM	608748. gene.
neXtProt	NX_O95393.
PharmGKB	PA134953092.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG280573.
HOGENOM	HOG000249477.
HOVERGEN	HBG106648.
InParanoid	O95393.
KO	K05503.
OMA	YEAYECR.
OrthoDB	EOG40GCQR.
PhylomeDB	O95393.
Enzyme and pathway databases
Reactome	REACT_118779. Extracellular matrix organization.
Gene expression databases
Bgee	O95393.
CleanEx	HS_BMP10.
Genevestigator	O95393.
GermOnline	ENSG00000163217. Homo sapiens.
Family and domain databases
InterPro	IPR002405. Inhibin_asu. IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
PANTHER	PTHR11848. PTHR11848. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
PRINTS	PR00669. INHIBINA.
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	27302.
NextBio	50289.
SOURCE	Search...

Entry information

Entry name

BMP10_HUMAN

Accession

Primary (citable) accession number: O95393
Secondary accession number(s): Q53R17, Q6NTE0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.