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O95393

- BMP10_HUMAN

UniProt

O95393 - BMP10_HUMAN

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Protein
Bone morphogenetic protein 10
Gene
BMP10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.3 Publications

GO - Molecular functioni

  1. hormone activity Source: BHF-UCL
  2. protein binding Source: BHF-UCL
  3. receptor serine/threonine kinase binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. BMP signaling pathway Source: BHF-UCL
  2. activin receptor signaling pathway Source: BHF-UCL
  3. adult heart development Source: BHF-UCL
  4. atrial cardiac muscle tissue morphogenesis Source: BHF-UCL
  5. cardiac muscle cell proliferation Source: UniProtKB
  6. cardiac muscle hypertrophy in response to stress Source: BHF-UCL
  7. cell adhesion Source: UniProtKB-KW
  8. extracellular matrix organization Source: Reactome
  9. heart trabecula formation Source: BHF-UCL
  10. negative regulation of cardiac muscle hypertrophy Source: BHF-UCL
  11. negative regulation of cell growth Source: UniProtKB
  12. negative regulation of cell migration Source: UniProtKB
  13. negative regulation of endothelial cell migration Source: BHF-UCL
  14. pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  15. positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
  16. positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
  17. positive regulation of cell proliferation involved in heart morphogenesis Source: BHF-UCL
  18. positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  19. positive regulation of sarcomere organization Source: BHF-UCL
  20. positive regulation of transcription, DNA-templated Source: BHF-UCL
  21. regulation of cardiac muscle contraction Source: BHF-UCL
  22. sarcomere organization Source: BHF-UCL
  23. ventricular cardiac muscle cell development Source: BHF-UCL
  24. ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_150331. Molecules associated with elastic fibres.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 10
Short name:
BMP-10
Gene namesi
Name:BMP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:20869. BMP10.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. Z disc Source: BHF-UCL
  2. cell surface Source: BHF-UCL
  3. cytoplasm Source: BHF-UCL
  4. extracellular region Source: Reactome
  5. extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134953092.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Propeptidei22 – 316295 Reviewed prediction
PRO_0000033888Add
BLAST
Chaini317 – 424108Bone morphogenetic protein 10
PRO_0000033889Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi131 – 1311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi323 ↔ 389 By similarity
Disulfide bondi352 ↔ 421 By similarity
Disulfide bondi356 ↔ 423 By similarity
Disulfide bondi388 – 388Interchain By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95393.
PRIDEiO95393.

PTM databases

PhosphoSiteiO95393.

Expressioni

Tissue specificityi

Detected in mammary epithelia (at protein level).1 Publication

Inductioni

Down-regulated in some breast cancer subtypes and breast cancer cell lines.1 Publication

Gene expression databases

BgeeiO95393.
CleanExiHS_BMP10.
GenevestigatoriO95393.

Organism-specific databases

HPAiHPA010987.

Interactioni

Subunit structurei

Homodimer; disulfide-linked By similarity.

Protein-protein interaction databases

BioGridi118125. 4 interactions.
IntActiO95393. 1 interaction.
STRINGi9606.ENSP00000295379.

Structurei

3D structure databases

ProteinModelPortaliO95393.
SMRiO95393. Positions 197-424.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG280573.
HOGENOMiHOG000249477.
HOVERGENiHBG106648.
InParanoidiO95393.
KOiK05503.
OMAiNVSIPHH.
OrthoDBiEOG7ZD1V3.
PhylomeDBiO95393.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95393-1 [UniParc]FASTAAdd to Basket

« Hide

MGSLVLTLCA LFCLAAYLVS GSPIMNLEQS PLEEDMSLFG DVFSEQDGVD    50
FNTLLQSMKD EFLKTLNLSD IPTQDSAKVD PPEYMLELYN KFATDRTSMP 100
SANIIRSFKN EDLFSQPVSF NGLRKYPLLF NVSIPHHEEV IMAELRLYTL 150
VQRDRMIYDG VDRKITIFEV LESKGDNEGE RNMLVLVSGE IYGTNSEWET 200
FDVTDAIRRW QKSGSSTHQL EVHIESKHDE AEDASSGRLE IDTSAQNKHN 250
PLLIVFSDDQ SSDKERKEEL NEMISHEQLP ELDNLGLDSF SSGPGEEALL 300
QMRSNIIYDS TARIRRNAKG NYCKRTPLYI DFKEIGWDSW IIAPPGYEAY 350
ECRGVCNYPL AEHLTPTKHA IIQALVHLKN SQKASKACCV PTKLEPISIL 400
YLDKGVVTYK FKYEGMAVSE CGCR 424
Length:424
Mass (Da):48,047
Last modified:May 1, 1999 - v1
Checksum:i3FDB3B7221BB2254
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti200 – 2001T → S.
Corresponds to variant rs2231342 [ dbSNP | Ensembl ].
VAR_052572
Natural varianti250 – 2501N → K.
Corresponds to variant rs2231345 [ dbSNP | Ensembl ].
VAR_052573

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti143 – 1431A → T in AAH69080. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF101441 mRNA. Translation: AAC77462.1.
AC097495 Genomic DNA. Translation: AAY15075.1.
BC069080 mRNA. Translation: AAH69080.1.
BC101734 mRNA. Translation: AAI01735.1.
BC105063 mRNA. Translation: AAI05064.1.
CCDSiCCDS1890.1.
RefSeqiNP_055297.1. NM_014482.1.
UniGeneiHs.158317.

Genome annotation databases

EnsembliENST00000295379; ENSP00000295379; ENSG00000163217.
GeneIDi27302.
KEGGihsa:27302.
UCSCiuc002sez.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bone morphogenetic protein 10 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF101441 mRNA. Translation: AAC77462.1 .
AC097495 Genomic DNA. Translation: AAY15075.1 .
BC069080 mRNA. Translation: AAH69080.1 .
BC101734 mRNA. Translation: AAI01735.1 .
BC105063 mRNA. Translation: AAI05064.1 .
CCDSi CCDS1890.1.
RefSeqi NP_055297.1. NM_014482.1.
UniGenei Hs.158317.

3D structure databases

ProteinModelPortali O95393.
SMRi O95393. Positions 197-424.
ModBasei Search...

Protein-protein interaction databases

BioGridi 118125. 4 interactions.
IntActi O95393. 1 interaction.
STRINGi 9606.ENSP00000295379.

PTM databases

PhosphoSitei O95393.

Proteomic databases

PaxDbi O95393.
PRIDEi O95393.

Protocols and materials databases

DNASUi 27302.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295379 ; ENSP00000295379 ; ENSG00000163217 .
GeneIDi 27302.
KEGGi hsa:27302.
UCSCi uc002sez.1. human.

Organism-specific databases

CTDi 27302.
GeneCardsi GC02M069092.
HGNCi HGNC:20869. BMP10.
HPAi HPA010987.
MIMi 608748. gene.
neXtProti NX_O95393.
PharmGKBi PA134953092.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG280573.
HOGENOMi HOG000249477.
HOVERGENi HBG106648.
InParanoidi O95393.
KOi K05503.
OMAi NVSIPHH.
OrthoDBi EOG7ZD1V3.
PhylomeDBi O95393.
TreeFami TF316134.

Enzyme and pathway databases

Reactomei REACT_150331. Molecules associated with elastic fibres.

Miscellaneous databases

GeneWikii Bone_morphogenetic_protein_10.
GenomeRNAii 27302.
NextBioi 50289.
PROi O95393.
SOURCEi Search...

Gene expression databases

Bgeei O95393.
CleanExi HS_BMP10.
Genevestigatori O95393.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
PRINTSi PR00669. INHIBINA.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens bone morphogenetic protein 10 (BMP-10) mRNA."
    Celeste A.J.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  4. "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses."
    Mazerbourg S., Sangkuhl K., Luo C.-W., Sudo S., Klein C., Hsueh A.J.W.
    J. Biol. Chem. 280:32122-32132(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells."
    David L., Mallet C., Mazerbourg S., Feige J.-J., Bailly S.
    Blood 109:1953-1961(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer."
    Ye L., Bokobza S., Li J., Moazzam M., Chen J., Mansel R.E., Jiang W.G.
    Cancer Sci. 101:2137-2144(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiBMP10_HUMAN
AccessioniPrimary (citable) accession number: O95393
Secondary accession number(s): Q53R17, Q6NTE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi