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O95393 (BMP10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bone morphogenetic protein 10

Short name=BMP-10
Gene names
Name:BMP10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. Ref.4 Ref.5 Ref.6

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Detected in mammary epithelia (at protein level). Ref.6

Induction

Down-regulated in some breast cancer subtypes and breast cancer cell lines. Ref.6

Sequence similarities

Belongs to the TGF-beta family.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionCytokine
Developmental protein
Growth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from direct assay Ref.4Ref.5. Source: BHF-UCL

activin receptor signaling pathway

Inferred from direct assay Ref.4Ref.5. Source: BHF-UCL

adult heart development

Inferred from sequence or structural similarity PubMed 10072785. Source: BHF-UCL

atrial cardiac muscle tissue morphogenesis

Inferred from sequence or structural similarity PubMed 10072785. Source: BHF-UCL

cardiac muscle cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

cardiac muscle hypertrophy in response to stress

Inferred by curator PubMed 17921333. Source: BHF-UCL

cell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

extracellular matrix organization

Traceable author statement. Source: Reactome

heart trabecula formation

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of cardiac muscle hypertrophy

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of cell growth

Inferred from direct assay Ref.5. Source: UniProtKB

negative regulation of cell migration

Inferred from direct assay Ref.5. Source: UniProtKB

negative regulation of endothelial cell migration

Inferred from direct assay Ref.5. Source: BHF-UCL

pathway-restricted SMAD protein phosphorylation

Inferred from direct assay Ref.4Ref.5. Source: BHF-UCL

positive regulation of cardiac muscle cell proliferation

Inferred from sequence or structural similarity PubMed 10072785. Source: BHF-UCL

positive regulation of cardiac muscle hypertrophy

Inferred from mutant phenotype PubMed 17921333. Source: BHF-UCL

positive regulation of cell proliferation involved in heart morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from direct assay Ref.4Ref.5PubMed 19903896. Source: BHF-UCL

positive regulation of sarcomere organization

Inferred from direct assay PubMed 17921333. Source: BHF-UCL

positive regulation of transcription, DNA-templated

Inferred from direct assay Ref.4Ref.5. Source: BHF-UCL

regulation of cardiac muscle contraction

Inferred from mutant phenotype PubMed 17921333. Source: BHF-UCL

sarcomere organization

Inferred from sequence or structural similarity. Source: BHF-UCL

ventricular cardiac muscle cell development

Inferred from sequence or structural similarity PubMed 10072785. Source: BHF-UCL

ventricular cardiac muscle tissue morphogenesis

Inferred from sequence or structural similarity PubMed 10072785. Source: BHF-UCL

   Cellular_componentZ disc

Inferred from direct assay PubMed 17921333. Source: BHF-UCL

cell surface

Inferred from direct assay PubMed 17921333. Source: BHF-UCL

cytoplasm

Inferred from direct assay PubMed 17921333. Source: BHF-UCL

extracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from direct assay PubMed 17921333. Source: BHF-UCL

   Molecular_functionhormone activity

Inferred from direct assay PubMed 17921333. Source: BHF-UCL

protein binding

Inferred from physical interaction Ref.5. Source: BHF-UCL

receptor serine/threonine kinase binding

Inferred from direct assay Ref.5. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Propeptide22 – 316295 Potential
PRO_0000033888
Chain317 – 424108Bone morphogenetic protein 10
PRO_0000033889

Amino acid modifications

Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation1311N-linked (GlcNAc...) Potential
Disulfide bond323 ↔ 389 By similarity
Disulfide bond352 ↔ 421 By similarity
Disulfide bond356 ↔ 423 By similarity
Disulfide bond388Interchain By similarity

Natural variations

Natural variant2001T → S.
Corresponds to variant rs2231342 [ dbSNP | Ensembl ].
VAR_052572
Natural variant2501N → K.
Corresponds to variant rs2231345 [ dbSNP | Ensembl ].
VAR_052573

Experimental info

Sequence conflict1431A → T in AAH69080. Ref.3

Sequences

Sequence LengthMass (Da)Tools
O95393 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 3FDB3B7221BB2254

FASTA42448,047
        10         20         30         40         50         60 
MGSLVLTLCA LFCLAAYLVS GSPIMNLEQS PLEEDMSLFG DVFSEQDGVD FNTLLQSMKD 

        70         80         90        100        110        120 
EFLKTLNLSD IPTQDSAKVD PPEYMLELYN KFATDRTSMP SANIIRSFKN EDLFSQPVSF 

       130        140        150        160        170        180 
NGLRKYPLLF NVSIPHHEEV IMAELRLYTL VQRDRMIYDG VDRKITIFEV LESKGDNEGE 

       190        200        210        220        230        240 
RNMLVLVSGE IYGTNSEWET FDVTDAIRRW QKSGSSTHQL EVHIESKHDE AEDASSGRLE 

       250        260        270        280        290        300 
IDTSAQNKHN PLLIVFSDDQ SSDKERKEEL NEMISHEQLP ELDNLGLDSF SSGPGEEALL 

       310        320        330        340        350        360 
QMRSNIIYDS TARIRRNAKG NYCKRTPLYI DFKEIGWDSW IIAPPGYEAY ECRGVCNYPL 

       370        380        390        400        410        420 
AEHLTPTKHA IIQALVHLKN SQKASKACCV PTKLEPISIL YLDKGVVTYK FKYEGMAVSE 


CGCR 

« Hide

References

« Hide 'large scale' references
[1]"Homo sapiens bone morphogenetic protein 10 (BMP-10) mRNA."
Celeste A.J.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.
[4]"Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses."
Mazerbourg S., Sangkuhl K., Luo C.-W., Sudo S., Klein C., Hsueh A.J.W.
J. Biol. Chem. 280:32122-32132(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells."
David L., Mallet C., Mazerbourg S., Feige J.-J., Bailly S.
Blood 109:1953-1961(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer."
Ye L., Bokobza S., Li J., Moazzam M., Chen J., Mansel R.E., Jiang W.G.
Cancer Sci. 101:2137-2144(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.
+Additional computationally mapped references.

Web resources

Wikipedia

Bone morphogenetic protein 10 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF101441 mRNA. Translation: AAC77462.1.
AC097495 Genomic DNA. Translation: AAY15075.1.
BC069080 mRNA. Translation: AAH69080.1.
BC101734 mRNA. Translation: AAI01735.1.
BC105063 mRNA. Translation: AAI05064.1.
CCDSCCDS1890.1.
RefSeqNP_055297.1. NM_014482.1.
UniGeneHs.158317.

3D structure databases

ProteinModelPortalO95393.
SMRO95393. Positions 197-424.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118125. 4 interactions.
IntActO95393. 1 interaction.
STRING9606.ENSP00000295379.

PTM databases

PhosphoSiteO95393.

Proteomic databases

PaxDbO95393.
PRIDEO95393.

Protocols and materials databases

DNASU27302.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295379; ENSP00000295379; ENSG00000163217.
GeneID27302.
KEGGhsa:27302.
UCSCuc002sez.1. human.

Organism-specific databases

CTD27302.
GeneCardsGC02M069092.
HGNCHGNC:20869. BMP10.
HPAHPA010987.
MIM608748. gene.
neXtProtNX_O95393.
PharmGKBPA134953092.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG280573.
HOGENOMHOG000249477.
HOVERGENHBG106648.
InParanoidO95393.
KOK05503.
OMANVSIPHH.
OrthoDBEOG7ZD1V3.
PhylomeDBO95393.
TreeFamTF316134.

Enzyme and pathway databases

ReactomeREACT_118779. Extracellular matrix organization.

Gene expression databases

BgeeO95393.
CleanExHS_BMP10.
GenevestigatorO95393.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSPR00669. INHIBINA.
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiBone_morphogenetic_protein_10.
GenomeRNAi27302.
NextBio50289.
PROO95393.
SOURCESearch...

Entry information

Entry nameBMP10_HUMAN
AccessionPrimary (citable) accession number: O95393
Secondary accession number(s): Q53R17, Q6NTE0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM