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O95393

- BMP10_HUMAN

UniProt

O95393 - BMP10_HUMAN

Protein

Bone morphogenetic protein 10

Gene

BMP10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.3 Publications

    GO - Molecular functioni

    1. hormone activity Source: BHF-UCL
    2. protein binding Source: BHF-UCL
    3. receptor serine/threonine kinase binding Source: UniProtKB

    GO - Biological processi

    1. activin receptor signaling pathway Source: BHF-UCL
    2. adult heart development Source: BHF-UCL
    3. atrial cardiac muscle tissue morphogenesis Source: BHF-UCL
    4. BMP signaling pathway Source: BHF-UCL
    5. cardiac muscle cell proliferation Source: UniProtKB
    6. cardiac muscle hypertrophy in response to stress Source: BHF-UCL
    7. cell adhesion Source: UniProtKB-KW
    8. extracellular matrix organization Source: Reactome
    9. heart trabecula formation Source: BHF-UCL
    10. negative regulation of cardiac muscle hypertrophy Source: BHF-UCL
    11. negative regulation of cell growth Source: UniProtKB
    12. negative regulation of cell migration Source: UniProtKB
    13. negative regulation of endothelial cell migration Source: BHF-UCL
    14. pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
    15. positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
    16. positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
    17. positive regulation of cell proliferation involved in heart morphogenesis Source: BHF-UCL
    18. positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
    19. positive regulation of sarcomere organization Source: BHF-UCL
    20. positive regulation of transcription, DNA-templated Source: BHF-UCL
    21. regulation of cardiac muscle contraction Source: BHF-UCL
    22. sarcomere organization Source: BHF-UCL
    23. ventricular cardiac muscle cell development Source: BHF-UCL
    24. ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_150331. Molecules associated with elastic fibres.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein 10
    Short name:
    BMP-10
    Gene namesi
    Name:BMP10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:20869. BMP10.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cell surface Source: BHF-UCL
    2. cytoplasm Source: BHF-UCL
    3. extracellular region Source: Reactome
    4. extracellular space Source: BHF-UCL
    5. Z disc Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134953092.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Propeptidei22 – 316295Sequence AnalysisPRO_0000033888Add
    BLAST
    Chaini317 – 424108Bone morphogenetic protein 10PRO_0000033889Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi323 ↔ 389By similarity
    Disulfide bondi352 ↔ 421By similarity
    Disulfide bondi356 ↔ 423By similarity
    Disulfide bondi388 – 388InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO95393.
    PRIDEiO95393.

    PTM databases

    PhosphoSiteiO95393.

    Expressioni

    Tissue specificityi

    Detected in mammary epithelia (at protein level).1 Publication

    Inductioni

    Down-regulated in some breast cancer subtypes and breast cancer cell lines.1 Publication

    Gene expression databases

    BgeeiO95393.
    CleanExiHS_BMP10.
    GenevestigatoriO95393.

    Organism-specific databases

    HPAiHPA010987.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    BioGridi118125. 4 interactions.
    IntActiO95393. 1 interaction.
    STRINGi9606.ENSP00000295379.

    Structurei

    3D structure databases

    ProteinModelPortaliO95393.
    SMRiO95393. Positions 197-424.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG280573.
    HOGENOMiHOG000249477.
    HOVERGENiHBG106648.
    InParanoidiO95393.
    KOiK05503.
    OMAiNVSIPHH.
    OrthoDBiEOG7ZD1V3.
    PhylomeDBiO95393.
    TreeFamiTF316134.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PRINTSiPR00669. INHIBINA.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O95393-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSLVLTLCA LFCLAAYLVS GSPIMNLEQS PLEEDMSLFG DVFSEQDGVD    50
    FNTLLQSMKD EFLKTLNLSD IPTQDSAKVD PPEYMLELYN KFATDRTSMP 100
    SANIIRSFKN EDLFSQPVSF NGLRKYPLLF NVSIPHHEEV IMAELRLYTL 150
    VQRDRMIYDG VDRKITIFEV LESKGDNEGE RNMLVLVSGE IYGTNSEWET 200
    FDVTDAIRRW QKSGSSTHQL EVHIESKHDE AEDASSGRLE IDTSAQNKHN 250
    PLLIVFSDDQ SSDKERKEEL NEMISHEQLP ELDNLGLDSF SSGPGEEALL 300
    QMRSNIIYDS TARIRRNAKG NYCKRTPLYI DFKEIGWDSW IIAPPGYEAY 350
    ECRGVCNYPL AEHLTPTKHA IIQALVHLKN SQKASKACCV PTKLEPISIL 400
    YLDKGVVTYK FKYEGMAVSE CGCR 424
    Length:424
    Mass (Da):48,047
    Last modified:May 1, 1999 - v1
    Checksum:i3FDB3B7221BB2254
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti143 – 1431A → T in AAH69080. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti200 – 2001T → S.
    Corresponds to variant rs2231342 [ dbSNP | Ensembl ].
    VAR_052572
    Natural varianti250 – 2501N → K.
    Corresponds to variant rs2231345 [ dbSNP | Ensembl ].
    VAR_052573

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF101441 mRNA. Translation: AAC77462.1.
    AC097495 Genomic DNA. Translation: AAY15075.1.
    BC069080 mRNA. Translation: AAH69080.1.
    BC101734 mRNA. Translation: AAI01735.1.
    BC105063 mRNA. Translation: AAI05064.1.
    CCDSiCCDS1890.1.
    RefSeqiNP_055297.1. NM_014482.1.
    UniGeneiHs.158317.

    Genome annotation databases

    EnsembliENST00000295379; ENSP00000295379; ENSG00000163217.
    GeneIDi27302.
    KEGGihsa:27302.
    UCSCiuc002sez.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Bone morphogenetic protein 10 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF101441 mRNA. Translation: AAC77462.1 .
    AC097495 Genomic DNA. Translation: AAY15075.1 .
    BC069080 mRNA. Translation: AAH69080.1 .
    BC101734 mRNA. Translation: AAI01735.1 .
    BC105063 mRNA. Translation: AAI05064.1 .
    CCDSi CCDS1890.1.
    RefSeqi NP_055297.1. NM_014482.1.
    UniGenei Hs.158317.

    3D structure databases

    ProteinModelPortali O95393.
    SMRi O95393. Positions 197-424.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118125. 4 interactions.
    IntActi O95393. 1 interaction.
    STRINGi 9606.ENSP00000295379.

    PTM databases

    PhosphoSitei O95393.

    Proteomic databases

    PaxDbi O95393.
    PRIDEi O95393.

    Protocols and materials databases

    DNASUi 27302.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295379 ; ENSP00000295379 ; ENSG00000163217 .
    GeneIDi 27302.
    KEGGi hsa:27302.
    UCSCi uc002sez.1. human.

    Organism-specific databases

    CTDi 27302.
    GeneCardsi GC02M069092.
    HGNCi HGNC:20869. BMP10.
    HPAi HPA010987.
    MIMi 608748. gene.
    neXtProti NX_O95393.
    PharmGKBi PA134953092.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG280573.
    HOGENOMi HOG000249477.
    HOVERGENi HBG106648.
    InParanoidi O95393.
    KOi K05503.
    OMAi NVSIPHH.
    OrthoDBi EOG7ZD1V3.
    PhylomeDBi O95393.
    TreeFami TF316134.

    Enzyme and pathway databases

    Reactomei REACT_150331. Molecules associated with elastic fibres.

    Miscellaneous databases

    GeneWikii Bone_morphogenetic_protein_10.
    GenomeRNAii 27302.
    NextBioi 50289.
    PROi O95393.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95393.
    CleanExi HS_BMP10.
    Genevestigatori O95393.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PRINTSi PR00669. INHIBINA.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homo sapiens bone morphogenetic protein 10 (BMP-10) mRNA."
      Celeste A.J.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    4. "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses."
      Mazerbourg S., Sangkuhl K., Luo C.-W., Sudo S., Klein C., Hsueh A.J.W.
      J. Biol. Chem. 280:32122-32132(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells."
      David L., Mallet C., Mazerbourg S., Feige J.-J., Bailly S.
      Blood 109:1953-1961(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer."
      Ye L., Bokobza S., Li J., Moazzam M., Chen J., Mansel R.E., Jiang W.G.
      Cancer Sci. 101:2137-2144(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.

    Entry informationi

    Entry nameiBMP10_HUMAN
    AccessioniPrimary (citable) accession number: O95393
    Secondary accession number(s): Q53R17, Q6NTE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3