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Protein

Bone morphogenetic protein 10

Gene

BMP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.3 Publications

GO - Molecular functioni

  1. cytokine activity Source: GO_Central
  2. hormone activity Source: BHF-UCL
  3. receptor serine/threonine kinase binding Source: UniProtKB
  4. telethonin binding Source: BHF-UCL
  5. transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

  1. activin receptor signaling pathway Source: BHF-UCL
  2. adult heart development Source: BHF-UCL
  3. atrial cardiac muscle tissue morphogenesis Source: BHF-UCL
  4. BMP signaling pathway Source: BHF-UCL
  5. cardiac muscle cell proliferation Source: UniProtKB
  6. cell adhesion Source: UniProtKB-KW
  7. extracellular matrix organization Source: Reactome
  8. heart trabecula formation Source: BHF-UCL
  9. negative regulation of cardiac muscle hypertrophy Source: BHF-UCL
  10. negative regulation of cell growth Source: UniProtKB
  11. negative regulation of cell migration Source: UniProtKB
  12. negative regulation of endothelial cell migration Source: BHF-UCL
  13. pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  14. positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
  15. positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
  16. positive regulation of cell proliferation involved in heart morphogenesis Source: BHF-UCL
  17. positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  18. positive regulation of sarcomere organization Source: BHF-UCL
  19. positive regulation of transcription, DNA-templated Source: BHF-UCL
  20. regulation of apoptotic process Source: GO_Central
  21. regulation of cardiac muscle contraction Source: BHF-UCL
  22. regulation of cardiac muscle hypertrophy in response to stress Source: BHF-UCL
  23. regulation of MAPK cascade Source: GO_Central
  24. sarcomere organization Source: BHF-UCL
  25. SMAD protein signal transduction Source: GO_Central
  26. ventricular cardiac muscle cell development Source: BHF-UCL
  27. ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_150331. Molecules associated with elastic fibres.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 10
Short name:
BMP-10
Gene namesi
Name:BMP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:20869. BMP10.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cell surface Source: BHF-UCL
  2. cytoplasm Source: BHF-UCL
  3. extracellular region Source: Reactome
  4. extracellular space Source: BHF-UCL
  5. Z disc Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134953092.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 316295Sequence AnalysisPRO_0000033888Add
BLAST
Chaini317 – 424108Bone morphogenetic protein 10PRO_0000033889Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi323 ↔ 389By similarity
Disulfide bondi352 ↔ 421By similarity
Disulfide bondi356 ↔ 423By similarity
Disulfide bondi388 – 388InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO95393.
PaxDbiO95393.
PRIDEiO95393.

PTM databases

PhosphoSiteiO95393.

Expressioni

Tissue specificityi

Detected in mammary epithelia (at protein level).1 Publication

Inductioni

Down-regulated in some breast cancer subtypes and breast cancer cell lines.1 Publication

Gene expression databases

BgeeiO95393.
CleanExiHS_BMP10.
GenevestigatoriO95393.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

BioGridi118125. 4 interactions.
IntActiO95393. 1 interaction.
STRINGi9606.ENSP00000295379.

Structurei

3D structure databases

ProteinModelPortaliO95393.
SMRiO95393. Positions 197-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG280573.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249477.
HOVERGENiHBG106648.
InParanoidiO95393.
KOiK05503.
OMAiNVSIPHH.
OrthoDBiEOG7ZD1V3.
PhylomeDBiO95393.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95393-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLVLTLCA LFCLAAYLVS GSPIMNLEQS PLEEDMSLFG DVFSEQDGVD
60 70 80 90 100
FNTLLQSMKD EFLKTLNLSD IPTQDSAKVD PPEYMLELYN KFATDRTSMP
110 120 130 140 150
SANIIRSFKN EDLFSQPVSF NGLRKYPLLF NVSIPHHEEV IMAELRLYTL
160 170 180 190 200
VQRDRMIYDG VDRKITIFEV LESKGDNEGE RNMLVLVSGE IYGTNSEWET
210 220 230 240 250
FDVTDAIRRW QKSGSSTHQL EVHIESKHDE AEDASSGRLE IDTSAQNKHN
260 270 280 290 300
PLLIVFSDDQ SSDKERKEEL NEMISHEQLP ELDNLGLDSF SSGPGEEALL
310 320 330 340 350
QMRSNIIYDS TARIRRNAKG NYCKRTPLYI DFKEIGWDSW IIAPPGYEAY
360 370 380 390 400
ECRGVCNYPL AEHLTPTKHA IIQALVHLKN SQKASKACCV PTKLEPISIL
410 420
YLDKGVVTYK FKYEGMAVSE CGCR
Length:424
Mass (Da):48,047
Last modified:April 30, 1999 - v1
Checksum:i3FDB3B7221BB2254
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti143 – 1431A → T in AAH69080 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti200 – 2001T → S.
Corresponds to variant rs2231342 [ dbSNP | Ensembl ].
VAR_052572
Natural varianti250 – 2501N → K.
Corresponds to variant rs2231345 [ dbSNP | Ensembl ].
VAR_052573

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF101441 mRNA. Translation: AAC77462.1.
AC097495 Genomic DNA. Translation: AAY15075.1.
BC069080 mRNA. Translation: AAH69080.1.
BC101734 mRNA. Translation: AAI01735.1.
BC105063 mRNA. Translation: AAI05064.1.
CCDSiCCDS1890.1.
RefSeqiNP_055297.1. NM_014482.1.
UniGeneiHs.158317.

Genome annotation databases

EnsembliENST00000295379; ENSP00000295379; ENSG00000163217.
GeneIDi27302.
KEGGihsa:27302.
UCSCiuc002sez.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Bone morphogenetic protein 10 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF101441 mRNA. Translation: AAC77462.1.
AC097495 Genomic DNA. Translation: AAY15075.1.
BC069080 mRNA. Translation: AAH69080.1.
BC101734 mRNA. Translation: AAI01735.1.
BC105063 mRNA. Translation: AAI05064.1.
CCDSiCCDS1890.1.
RefSeqiNP_055297.1. NM_014482.1.
UniGeneiHs.158317.

3D structure databases

ProteinModelPortaliO95393.
SMRiO95393. Positions 197-424.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118125. 4 interactions.
IntActiO95393. 1 interaction.
STRINGi9606.ENSP00000295379.

PTM databases

PhosphoSiteiO95393.

Proteomic databases

MaxQBiO95393.
PaxDbiO95393.
PRIDEiO95393.

Protocols and materials databases

DNASUi27302.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295379; ENSP00000295379; ENSG00000163217.
GeneIDi27302.
KEGGihsa:27302.
UCSCiuc002sez.1. human.

Organism-specific databases

CTDi27302.
GeneCardsiGC02M069092.
HGNCiHGNC:20869. BMP10.
MIMi608748. gene.
neXtProtiNX_O95393.
PharmGKBiPA134953092.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG280573.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249477.
HOVERGENiHBG106648.
InParanoidiO95393.
KOiK05503.
OMAiNVSIPHH.
OrthoDBiEOG7ZD1V3.
PhylomeDBiO95393.
TreeFamiTF316134.

Enzyme and pathway databases

ReactomeiREACT_150331. Molecules associated with elastic fibres.

Miscellaneous databases

GeneWikiiBone_morphogenetic_protein_10.
GenomeRNAii27302.
NextBioi50289.
PROiO95393.
SOURCEiSearch...

Gene expression databases

BgeeiO95393.
CleanExiHS_BMP10.
GenevestigatoriO95393.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens bone morphogenetic protein 10 (BMP-10) mRNA."
    Celeste A.J.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  4. "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses."
    Mazerbourg S., Sangkuhl K., Luo C.-W., Sudo S., Klein C., Hsueh A.J.W.
    J. Biol. Chem. 280:32122-32132(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells."
    David L., Mallet C., Mazerbourg S., Feige J.-J., Bailly S.
    Blood 109:1953-1961(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer."
    Ye L., Bokobza S., Li J., Moazzam M., Chen J., Mansel R.E., Jiang W.G.
    Cancer Sci. 101:2137-2144(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiBMP10_HUMAN
AccessioniPrimary (citable) accession number: O95393
Secondary accession number(s): Q53R17, Q6NTE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2001
Last sequence update: April 30, 1999
Last modified: March 3, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.