Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O95390

- GDF11_HUMAN

UniProt

O95390 - GDF11_HUMAN

Protein

Growth/differentiation factor 11

Gene

GDF11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.

    GO - Biological processi

    1. camera-type eye morphogenesis Source: Ensembl
    2. cell maturation Source: Ensembl
    3. growth Source: InterPro
    4. mesoderm development Source: UniProtKB
    5. metanephros development Source: Ensembl
    6. negative regulation of cell differentiation Source: Ensembl
    7. negative regulation of cell proliferation Source: Ensembl
    8. nervous system development Source: UniProtKB
    9. pancreas development Source: Ensembl
    10. skeletal system development Source: UniProtKB
    11. spinal cord anterior/posterior patterning Source: Ensembl
    12. ureteric bud development Source: Ensembl

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Enzyme and pathway databases

    SignaLinkiO95390.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth/differentiation factor 11
    Short name:
    GDF-11
    Alternative name(s):
    Bone morphogenetic protein 11
    Short name:
    BMP-11
    Gene namesi
    Name:GDF11
    Synonyms:BMP11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:4216. GDF11.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW
    2. protein complex Source: MGI

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28631.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Propeptidei25 – 298274By similarityPRO_0000033986Add
    BLAST
    Chaini299 – 407109Growth/differentiation factor 11PRO_0000033987Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi313 ↔ 372By similarity
    Disulfide bondi341 ↔ 404By similarity
    Disulfide bondi345 ↔ 406By similarity
    Disulfide bondi371 – 371InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO95390.
    PRIDEiO95390.

    PTM databases

    PhosphoSiteiO95390.

    Expressioni

    Gene expression databases

    BgeeiO95390.
    CleanExiHS_GDF11.
    GenevestigatoriO95390.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    IntActiO95390. 6 interactions.
    MINTiMINT-2798837.
    STRINGi9606.ENSP00000257868.

    Structurei

    3D structure databases

    ProteinModelPortaliO95390.
    SMRiO95390. Positions 75-407.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi29 – 4113Poly-AlaAdd
    BLAST
    Compositional biasi210 – 2156Poly-Gly

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG310007.
    HOGENOMiHOG000006566.
    HOVERGENiHBG000217.
    InParanoidiO95390.
    KOiK05497.
    OMAiHGKIPGM.
    OrthoDBiEOG74R1Q4.
    PhylomeDBiO95390.
    TreeFamiTF318514.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O95390-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLAAPLLLG FLLLALELRP RGEAAEGPAA AAAAAAAAAA AGVGGERSSR    50
    PAPSVAPEPD GCPVCVWRQH SRELRLESIK SQILSKLRLK EAPNISREVV 100
    KQLLPKAPPL QQILDLHDFQ GDALQPEDFL EEDEYHATTE TVISMAQETD 150
    PAVQTDGSPL CCHFHFSPKV MFTKVLKAQL WVYLRPVPRP ATVYLQILRL 200
    KPLTGEGTAG GGGGGRRHIR IRSLKIELHS RSGHWQSIDF KQVLHSWFRQ 250
    PQSNWGIEIN AFDPSGTDLA VTSLGPGAEG LHPFMELRVL ENTKRSRRNL 300
    GLDCDEHSSE SRCCRYPLTV DFEAFGWDWI IAPKRYKANY CSGQCEYMFM 350
    QKYPHTHLVQ QANPRGSAGP CCTPTKMSPI NMLYFNDKQQ IIYGKIPGMV 400
    VDRCGCS 407
    Length:407
    Mass (Da):45,091
    Last modified:May 1, 1999 - v1
    Checksum:iE8FF48E363635BA8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF100907 mRNA. Translation: AAC72852.1.
    AF028333 mRNA. Translation: AAF21630.1.
    AF028334 Genomic DNA. Translation: AAF21631.1.
    CCDSiCCDS8891.1.
    RefSeqiNP_005802.1. NM_005811.3.
    XP_006719256.1. XM_006719193.1.
    XP_006719257.1. XM_006719194.1.
    UniGeneiHs.600883.

    Genome annotation databases

    EnsembliENST00000257868; ENSP00000257868; ENSG00000135414.
    GeneIDi10220.
    KEGGihsa:10220.
    UCSCiuc001shq.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF100907 mRNA. Translation: AAC72852.1 .
    AF028333 mRNA. Translation: AAF21630.1 .
    AF028334 Genomic DNA. Translation: AAF21631.1 .
    CCDSi CCDS8891.1.
    RefSeqi NP_005802.1. NM_005811.3.
    XP_006719256.1. XM_006719193.1.
    XP_006719257.1. XM_006719194.1.
    UniGenei Hs.600883.

    3D structure databases

    ProteinModelPortali O95390.
    SMRi O95390. Positions 75-407.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O95390. 6 interactions.
    MINTi MINT-2798837.
    STRINGi 9606.ENSP00000257868.

    PTM databases

    PhosphoSitei O95390.

    Proteomic databases

    PaxDbi O95390.
    PRIDEi O95390.

    Protocols and materials databases

    DNASUi 10220.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000257868 ; ENSP00000257868 ; ENSG00000135414 .
    GeneIDi 10220.
    KEGGi hsa:10220.
    UCSCi uc001shq.3. human.

    Organism-specific databases

    CTDi 10220.
    GeneCardsi GC12P056137.
    HGNCi HGNC:4216. GDF11.
    MIMi 603936. gene.
    neXtProti NX_O95390.
    PharmGKBi PA28631.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG310007.
    HOGENOMi HOG000006566.
    HOVERGENi HBG000217.
    InParanoidi O95390.
    KOi K05497.
    OMAi HGKIPGM.
    OrthoDBi EOG74R1Q4.
    PhylomeDBi O95390.
    TreeFami TF318514.

    Enzyme and pathway databases

    SignaLinki O95390.

    Miscellaneous databases

    GeneWikii GDF11.
    GenomeRNAii 10220.
    NextBioi 38700.
    PROi O95390.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95390.
    CleanExi HS_GDF11.
    Genevestigatori O95390.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel BMP expressed in developing mouse limb, spinal cord, and tail bud is a potent mesoderm inducer in Xenopus embryos."
      Gamer L.W., Wolfman N.M., Celeste A.J., Hattersley G., Hewick R., Rosen V.
      Dev. Biol. 208:222-232(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    2. "Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11."
      McPherron A.C., Lawler A.M., Lee S.-J.
      Nat. Genet. 22:260-264(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

    Entry informationi

    Entry nameiGDF11_HUMAN
    AccessioniPrimary (citable) accession number: O95390
    Secondary accession number(s): Q9UID1, Q9UID2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3