Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O95390 (GDF11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Growth/differentiation factor 11

Short name=GDF-11
Alternative name(s):
Bone morphogenetic protein 11
Short name=BMP-11
Gene names
Name:GDF11
Synonyms:BMP11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the TGF-beta family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Propeptide25 – 298274 By similarity
PRO_0000033986
Chain299 – 407109Growth/differentiation factor 11
PRO_0000033987

Regions

Compositional bias29 – 4113Poly-Ala
Compositional bias210 – 2156Poly-Gly

Amino acid modifications

Glycosylation941N-linked (GlcNAc...) Potential
Disulfide bond313 ↔ 372 By similarity
Disulfide bond341 ↔ 404 By similarity
Disulfide bond345 ↔ 406 By similarity
Disulfide bond371Interchain By similarity

Sequences

Sequence LengthMass (Da)Tools
O95390 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: E8FF48E363635BA8

FASTA40745,091
        10         20         30         40         50         60 
MVLAAPLLLG FLLLALELRP RGEAAEGPAA AAAAAAAAAA AGVGGERSSR PAPSVAPEPD 

        70         80         90        100        110        120 
GCPVCVWRQH SRELRLESIK SQILSKLRLK EAPNISREVV KQLLPKAPPL QQILDLHDFQ 

       130        140        150        160        170        180 
GDALQPEDFL EEDEYHATTE TVISMAQETD PAVQTDGSPL CCHFHFSPKV MFTKVLKAQL 

       190        200        210        220        230        240 
WVYLRPVPRP ATVYLQILRL KPLTGEGTAG GGGGGRRHIR IRSLKIELHS RSGHWQSIDF 

       250        260        270        280        290        300 
KQVLHSWFRQ PQSNWGIEIN AFDPSGTDLA VTSLGPGAEG LHPFMELRVL ENTKRSRRNL 

       310        320        330        340        350        360 
GLDCDEHSSE SRCCRYPLTV DFEAFGWDWI IAPKRYKANY CSGQCEYMFM QKYPHTHLVQ 

       370        380        390        400 
QANPRGSAGP CCTPTKMSPI NMLYFNDKQQ IIYGKIPGMV VDRCGCS 

« Hide

References

[1]"A novel BMP expressed in developing mouse limb, spinal cord, and tail bud is a potent mesoderm inducer in Xenopus embryos."
Gamer L.W., Wolfman N.M., Celeste A.J., Hattersley G., Hewick R., Rosen V.
Dev. Biol. 208:222-232(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal brain.
[2]"Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11."
McPherron A.C., Lawler A.M., Lee S.-J.
Nat. Genet. 22:260-264(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF100907 mRNA. Translation: AAC72852.1.
AF028333 mRNA. Translation: AAF21630.1.
AF028334 Genomic DNA. Translation: AAF21631.1.
RefSeqNP_005802.1. NM_005811.3.
UniGeneHs.600883.

3D structure databases

ProteinModelPortalO95390.
SMRO95390. Positions 75-407.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO95390. 6 interactions.
MINTMINT-2798837.
STRING9606.ENSP00000257868.

PTM databases

PhosphoSiteO95390.

Proteomic databases

PaxDbO95390.
PRIDEO95390.

Protocols and materials databases

DNASU10220.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000257868; ENSP00000257868; ENSG00000135414.
GeneID10220.
KEGGhsa:10220.
UCSCuc001shq.3. human.

Organism-specific databases

CTD10220.
GeneCardsGC12P056137.
HGNCHGNC:4216. GDF11.
MIM603936. gene.
neXtProtNX_O95390.
PharmGKBPA28631.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG310007.
HOGENOMHOG000006566.
HOVERGENHBG000217.
InParanoidO95390.
KOK05497.
OMAHGKIPGM.
OrthoDBEOG74R1Q4.
PhylomeDBO95390.
TreeFamTF318514.

Enzyme and pathway databases

SignaLinkO95390.

Gene expression databases

BgeeO95390.
CleanExHS_GDF11.
GenevestigatorO95390.

Family and domain databases

InterProIPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGDF11.
GenomeRNAi10220.
NextBio38700.
PROO95390.
SOURCESearch...

Entry information

Entry nameGDF11_HUMAN
AccessionPrimary (citable) accession number: O95390
Secondary accession number(s): Q9UID1, Q9UID2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 1999
Last modified: March 19, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM