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Protein

Growth/differentiation factor 11

Gene

GDF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135414-MONOMER.
SignaLinkiO95390.
SIGNORiO95390.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 11
Short name:
GDF-11
Alternative name(s):
Bone morphogenetic protein 11
Short name:
BMP-11
Gene namesi
Name:GDF11
Synonyms:BMP11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:4216. GDF11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10220.
OpenTargetsiENSG00000135414.
PharmGKBiPA28631.

Polymorphism and mutation databases

BioMutaiGDF11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000003398625 – 298By similarityAdd BLAST274
ChainiPRO_0000033987299 – 407Growth/differentiation factor 11Add BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi94N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi313 ↔ 372By similarity
Disulfide bondi341 ↔ 404By similarity
Disulfide bondi345 ↔ 406By similarity
Disulfide bondi371InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95390.
PeptideAtlasiO95390.
PRIDEiO95390.

PTM databases

iPTMnetiO95390.
PhosphoSitePlusiO95390.

Expressioni

Gene expression databases

BgeeiENSG00000135414.
CleanExiHS_GDF11.
ExpressionAtlasiO95390. baseline and differential.
GenevisibleiO95390. HS.

Organism-specific databases

HPAiHPA060985.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115515. 14 interactors.
IntActiO95390. 6 interactors.
MINTiMINT-2798837.
STRINGi9606.ENSP00000257868.

Structurei

Secondary structure

1407
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi312 – 316Combined sources5
Beta strandi319 – 321Combined sources3
Turni322 – 326Combined sources5
Beta strandi330 – 332Combined sources3
Beta strandi334 – 337Combined sources4
Beta strandi340 – 342Combined sources3
Turni347 – 350Combined sources4
Helixi355 – 362Combined sources8
Beta strandi371 – 385Combined sources15
Beta strandi387 – 389Combined sources3
Beta strandi391 – 407Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E4GX-ray1.50A299-407[»]
ProteinModelPortaliO95390.
SMRiO95390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi29 – 41Poly-AlaAdd BLAST13
Compositional biasi210 – 215Poly-Gly6

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000006566.
HOVERGENiHBG000217.
InParanoidiO95390.
KOiK05497.
OMAiGSHECSA.
OrthoDBiEOG091G078V.
PhylomeDBiO95390.
TreeFamiTF318514.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95390-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLAAPLLLG FLLLALELRP RGEAAEGPAA AAAAAAAAAA AGVGGERSSR
60 70 80 90 100
PAPSVAPEPD GCPVCVWRQH SRELRLESIK SQILSKLRLK EAPNISREVV
110 120 130 140 150
KQLLPKAPPL QQILDLHDFQ GDALQPEDFL EEDEYHATTE TVISMAQETD
160 170 180 190 200
PAVQTDGSPL CCHFHFSPKV MFTKVLKAQL WVYLRPVPRP ATVYLQILRL
210 220 230 240 250
KPLTGEGTAG GGGGGRRHIR IRSLKIELHS RSGHWQSIDF KQVLHSWFRQ
260 270 280 290 300
PQSNWGIEIN AFDPSGTDLA VTSLGPGAEG LHPFMELRVL ENTKRSRRNL
310 320 330 340 350
GLDCDEHSSE SRCCRYPLTV DFEAFGWDWI IAPKRYKANY CSGQCEYMFM
360 370 380 390 400
QKYPHTHLVQ QANPRGSAGP CCTPTKMSPI NMLYFNDKQQ IIYGKIPGMV

VDRCGCS
Length:407
Mass (Da):45,091
Last modified:May 1, 1999 - v1
Checksum:iE8FF48E363635BA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100907 mRNA. Translation: AAC72852.1.
AF028333 mRNA. Translation: AAF21630.1.
AF028334 Genomic DNA. Translation: AAF21631.1.
CCDSiCCDS8891.1.
RefSeqiNP_005802.1. NM_005811.4.
XP_006719257.1. XM_006719194.3.
UniGeneiHs.600883.

Genome annotation databases

EnsembliENST00000257868; ENSP00000257868; ENSG00000135414.
GeneIDi10220.
KEGGihsa:10220.
UCSCiuc001shq.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100907 mRNA. Translation: AAC72852.1.
AF028333 mRNA. Translation: AAF21630.1.
AF028334 Genomic DNA. Translation: AAF21631.1.
CCDSiCCDS8891.1.
RefSeqiNP_005802.1. NM_005811.4.
XP_006719257.1. XM_006719194.3.
UniGeneiHs.600883.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E4GX-ray1.50A299-407[»]
ProteinModelPortaliO95390.
SMRiO95390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115515. 14 interactors.
IntActiO95390. 6 interactors.
MINTiMINT-2798837.
STRINGi9606.ENSP00000257868.

PTM databases

iPTMnetiO95390.
PhosphoSitePlusiO95390.

Polymorphism and mutation databases

BioMutaiGDF11.

Proteomic databases

PaxDbiO95390.
PeptideAtlasiO95390.
PRIDEiO95390.

Protocols and materials databases

DNASUi10220.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257868; ENSP00000257868; ENSG00000135414.
GeneIDi10220.
KEGGihsa:10220.
UCSCiuc001shq.4. human.

Organism-specific databases

CTDi10220.
DisGeNETi10220.
GeneCardsiGDF11.
HGNCiHGNC:4216. GDF11.
HPAiHPA060985.
MIMi603936. gene.
neXtProtiNX_O95390.
OpenTargetsiENSG00000135414.
PharmGKBiPA28631.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000006566.
HOVERGENiHBG000217.
InParanoidiO95390.
KOiK05497.
OMAiGSHECSA.
OrthoDBiEOG091G078V.
PhylomeDBiO95390.
TreeFamiTF318514.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135414-MONOMER.
SignaLinkiO95390.
SIGNORiO95390.

Miscellaneous databases

ChiTaRSiGDF11. human.
GeneWikiiGDF11.
GenomeRNAii10220.
PROiO95390.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135414.
CleanExiHS_GDF11.
ExpressionAtlasiO95390. baseline and differential.
GenevisibleiO95390. HS.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGDF11_HUMAN
AccessioniPrimary (citable) accession number: O95390
Secondary accession number(s): Q9UID1, Q9UID2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.