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O95390

- GDF11_HUMAN

UniProt

O95390 - GDF11_HUMAN

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Protein

Growth/differentiation factor 11

Gene

GDF11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.

GO - Biological processi

  1. camera-type eye morphogenesis Source: Ensembl
  2. cell maturation Source: Ensembl
  3. growth Source: InterPro
  4. mesoderm development Source: UniProtKB
  5. metanephros development Source: Ensembl
  6. negative regulation of cell differentiation Source: Ensembl
  7. negative regulation of cell proliferation Source: Ensembl
  8. nervous system development Source: UniProtKB
  9. palate development Source: Ensembl
  10. pancreas development Source: Ensembl
  11. skeletal system development Source: UniProtKB
  12. spinal cord anterior/posterior patterning Source: Ensembl
  13. ureteric bud development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

SignaLinkiO95390.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 11
Short name:
GDF-11
Alternative name(s):
Bone morphogenetic protein 11
Short name:
BMP-11
Gene namesi
Name:GDF11
Synonyms:BMP11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:4216. GDF11.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28631.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Propeptidei25 – 298274By similarityPRO_0000033986Add
BLAST
Chaini299 – 407109Growth/differentiation factor 11PRO_0000033987Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi313 ↔ 372By similarity
Disulfide bondi341 ↔ 404By similarity
Disulfide bondi345 ↔ 406By similarity
Disulfide bondi371 – 371InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95390.
PRIDEiO95390.

PTM databases

PhosphoSiteiO95390.

Expressioni

Gene expression databases

BgeeiO95390.
CleanExiHS_GDF11.
GenevestigatoriO95390.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

BioGridi115515. 5 interactions.
IntActiO95390. 6 interactions.
MINTiMINT-2798837.
STRINGi9606.ENSP00000257868.

Structurei

3D structure databases

ProteinModelPortaliO95390.
SMRiO95390. Positions 75-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi29 – 4113Poly-AlaAdd
BLAST
Compositional biasi210 – 2156Poly-Gly

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG310007.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000006566.
HOVERGENiHBG000217.
InParanoidiO95390.
KOiK05497.
OMAiHGKIPGM.
OrthoDBiEOG74R1Q4.
PhylomeDBiO95390.
TreeFamiTF318514.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95390-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLAAPLLLG FLLLALELRP RGEAAEGPAA AAAAAAAAAA AGVGGERSSR
60 70 80 90 100
PAPSVAPEPD GCPVCVWRQH SRELRLESIK SQILSKLRLK EAPNISREVV
110 120 130 140 150
KQLLPKAPPL QQILDLHDFQ GDALQPEDFL EEDEYHATTE TVISMAQETD
160 170 180 190 200
PAVQTDGSPL CCHFHFSPKV MFTKVLKAQL WVYLRPVPRP ATVYLQILRL
210 220 230 240 250
KPLTGEGTAG GGGGGRRHIR IRSLKIELHS RSGHWQSIDF KQVLHSWFRQ
260 270 280 290 300
PQSNWGIEIN AFDPSGTDLA VTSLGPGAEG LHPFMELRVL ENTKRSRRNL
310 320 330 340 350
GLDCDEHSSE SRCCRYPLTV DFEAFGWDWI IAPKRYKANY CSGQCEYMFM
360 370 380 390 400
QKYPHTHLVQ QANPRGSAGP CCTPTKMSPI NMLYFNDKQQ IIYGKIPGMV

VDRCGCS
Length:407
Mass (Da):45,091
Last modified:May 1, 1999 - v1
Checksum:iE8FF48E363635BA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100907 mRNA. Translation: AAC72852.1.
AF028333 mRNA. Translation: AAF21630.1.
AF028334 Genomic DNA. Translation: AAF21631.1.
CCDSiCCDS8891.1.
RefSeqiNP_005802.1. NM_005811.3.
XP_006719256.1. XM_006719193.1.
XP_006719257.1. XM_006719194.1.
UniGeneiHs.600883.

Genome annotation databases

EnsembliENST00000257868; ENSP00000257868; ENSG00000135414.
GeneIDi10220.
KEGGihsa:10220.
UCSCiuc001shq.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100907 mRNA. Translation: AAC72852.1 .
AF028333 mRNA. Translation: AAF21630.1 .
AF028334 Genomic DNA. Translation: AAF21631.1 .
CCDSi CCDS8891.1.
RefSeqi NP_005802.1. NM_005811.3.
XP_006719256.1. XM_006719193.1.
XP_006719257.1. XM_006719194.1.
UniGenei Hs.600883.

3D structure databases

ProteinModelPortali O95390.
SMRi O95390. Positions 75-407.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115515. 5 interactions.
IntActi O95390. 6 interactions.
MINTi MINT-2798837.
STRINGi 9606.ENSP00000257868.

PTM databases

PhosphoSitei O95390.

Proteomic databases

PaxDbi O95390.
PRIDEi O95390.

Protocols and materials databases

DNASUi 10220.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000257868 ; ENSP00000257868 ; ENSG00000135414 .
GeneIDi 10220.
KEGGi hsa:10220.
UCSCi uc001shq.3. human.

Organism-specific databases

CTDi 10220.
GeneCardsi GC12P056137.
HGNCi HGNC:4216. GDF11.
MIMi 603936. gene.
neXtProti NX_O95390.
PharmGKBi PA28631.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG310007.
GeneTreei ENSGT00760000119112.
HOGENOMi HOG000006566.
HOVERGENi HBG000217.
InParanoidi O95390.
KOi K05497.
OMAi HGKIPGM.
OrthoDBi EOG74R1Q4.
PhylomeDBi O95390.
TreeFami TF318514.

Enzyme and pathway databases

SignaLinki O95390.

Miscellaneous databases

ChiTaRSi GDF11. human.
GeneWikii GDF11.
GenomeRNAii 10220.
NextBioi 38700.
PROi O95390.
SOURCEi Search...

Gene expression databases

Bgeei O95390.
CleanExi HS_GDF11.
Genevestigatori O95390.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel BMP expressed in developing mouse limb, spinal cord, and tail bud is a potent mesoderm inducer in Xenopus embryos."
    Gamer L.W., Wolfman N.M., Celeste A.J., Hattersley G., Hewick R., Rosen V.
    Dev. Biol. 208:222-232(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11."
    McPherron A.C., Lawler A.M., Lee S.-J.
    Nat. Genet. 22:260-264(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Entry informationi

Entry nameiGDF11_HUMAN
AccessioniPrimary (citable) accession number: O95390
Secondary accession number(s): Q9UID1, Q9UID2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3