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Protein

WNT1-inducible-signaling pathway protein 3

Gene

WISP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Appears to be required for normal postnatal skeletal growth and cartilage homeostasis.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: GO_Central
  • cell-cell signaling Source: ProtInc
  • negative regulation of cell death Source: GO_Central
  • regulation of cell growth Source: InterPro
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
WNT1-inducible-signaling pathway protein 3
Short name:
WISP-3
Alternative name(s):
CCN family member 6
Gene namesi
Name:WISP3
Synonyms:CCN6
ORF Names:UNQ462/PRO790/PRO956
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112761.18
HGNCiHGNC:12771 WISP3
MIMi603400 gene
neXtProtiNX_O95389

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Progressive pseudorheumatoid arthropathy of childhood (PPAC)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal recessive disorder characterized by stiffness and swelling of joints, motor weakness and joint contractures. Signs and symptoms of the disease develop typically between three and eight years of age. This progressive disease is a primary disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging.
See also OMIM:208230
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01622578C → R in PPAC. 1 PublicationCorresponds to variant dbSNP:rs121908902EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi8838
MalaCardsiWISP3
MIMi208230 phenotype
OpenTargetsiENSG00000112761
Orphaneti1159 Progressive pseudorheumatoid arthropathy of childhood
PharmGKBiPA37374

Polymorphism and mutation databases

BioMutaiWISP3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001441224 – 354WNT1-inducible-signaling pathway protein 3Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi268 ↔ 305By similarity
Disulfide bondi285 ↔ 319By similarity
Disulfide bondi296 ↔ 335By similarity
Disulfide bondi299 ↔ 337By similarity
Disulfide bondi304 ↔ 341By similarity
Glycosylationi308N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95389
PeptideAtlasiO95389
PRIDEiO95389
ProteomicsDBi50840
50841 [O95389-2]

PTM databases

iPTMnetiO95389
PhosphoSitePlusiO95389

Expressioni

Tissue specificityi

Predominant expression in adult kidney and testis and fetal kidney. Weaker expression found in placenta, ovary, prostate and small intestine. Also expressed in skeletally-derived cells such as synoviocytes and articular cartilage chondrocytes.

Gene expression databases

BgeeiENSG00000112761
CleanExiHS_WISP3
ExpressionAtlasiO95389 baseline and differential
GenevisibleiO95389 HS

Organism-specific databases

HPAiHPA062438
HPA078340

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114365, 6 interactors
STRINGi9606.ENSP00000354734

Structurei

3D structure databases

ProteinModelPortaliO95389
SMRiO95389
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 117IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST74
Domaini208 – 253TSP type-1PROSITE-ProRule annotationAdd BLAST46
Domaini268 – 342CTCKPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Belongs to the CCN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJZE Eukaryota
ENOG4110BH0 LUCA
GeneTreeiENSGT00760000119225
HOGENOMiHOG000231462
HOVERGENiHBG000635
InParanoidiO95389
OMAiSNCEMRK
OrthoDBiEOG091G0SQP
PhylomeDBiO95389
TreeFamiTF326070

Family and domain databases

Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR006208 Glyco_hormone_CN
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR012395 IGFBP_CNN
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
PF00219 IGFBP, 1 hit
PIRSFiPIRSF036495 IGFBP_rP_CNN, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00121 IB, 1 hit
SM00209 TSP1, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS01225 CTCK_2, 1 hit
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS50092 TSP1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95389-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQGLLFSTLL LAGLAQFCCR VQGTGPLDTT PEGRPGEVSD APQRKQFCHW
60 70 80 90 100
PCKCPQQKPR CPPGVSLVRD GCGCCKICAK QPGEICNEAD LCDPHKGLYC
110 120 130 140 150
DYSVDRPRYE TGVCAYLVAV GCEFNQVHYH NGQVFQPNPL FSCLCVSGAI
160 170 180 190 200
GCTPLFIPKL AGSHCSGAKG GKKSDQSNCS LEPLLQQLST SYKTMPAYRN
210 220 230 240 250
LPLIWKKKCL VQATKWTPCS RTCGMGISNR VTNENSNCEM RKEKRLCYIQ
260 270 280 290 300
PCDSNILKTI KIPKGKTCQP TFQLSKAEKF VFSGCSSTQS YKPTFCGICL
310 320 330 340 350
DKRCCIPNKS KMITIQFDCP NEGSFKWKML WITSCVCQRN CREPGDIFSE

LKIL
Length:354
Mass (Da):39,293
Last modified:May 1, 1999 - v1
Checksum:i67F48D0D5C2F5EE3
GO
Isoform 2 (identifier: O95389-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNKRRLLYPSGWLHGPSDM

Show »
Length:372
Mass (Da):41,402
Checksum:i449A31188D480511
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200N → D in AAQ88715 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01622456Q → H Common polymorphism. 1 PublicationCorresponds to variant dbSNP:rs1230345EnsemblClinVar.1
Natural variantiVAR_04956760R → C. Corresponds to variant dbSNP:rs17073260EnsemblClinVar.1
Natural variantiVAR_01622578C → R in PPAC. 1 PublicationCorresponds to variant dbSNP:rs121908902EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0378031M → MNKRRLLYPSGWLHGPSDM in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100781 mRNA Translation: AAC96323.1
AY358349 mRNA Translation: AAQ88715.1
AY358350 mRNA Translation: AAQ88716.1
Z99289 Genomic DNA No translation available.
AL512299 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48273.1
CH471051 Genomic DNA Translation: EAW48275.1
BC105941 mRNA Translation: AAI05942.1
CCDSiCCDS5097.1 [O95389-2]
CCDS5098.1 [O95389-1]
RefSeqiNP_003871.1, NM_003880.3 [O95389-1]
NP_937882.1, NM_198239.1 [O95389-2]
XP_011534522.1, XM_011536220.1 [O95389-1]
UniGeneiHs.558428

Genome annotation databases

EnsembliENST00000230529; ENSP00000230529; ENSG00000112761 [O95389-1]
ENST00000361714; ENSP00000354734; ENSG00000112761 [O95389-1]
ENST00000368666; ENSP00000357655; ENSG00000112761 [O95389-2]
ENST00000604763; ENSP00000473777; ENSG00000112761 [O95389-1]
GeneIDi8838
KEGGihsa:8838
UCSCiuc003pvm.4 human [O95389-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWISP3_HUMAN
AccessioniPrimary (citable) accession number: O95389
Secondary accession number(s): Q3KR29, Q5H8W4, Q6UXH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: May 1, 1999
Last modified: June 20, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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