O95382 (M3K6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitogen-activated protein kinase kinase kinase 6
EC=2.7.11.25

Alternative name(s):
Apoptosis signal-regulating kinase 2

Gene names

Name:	MAP3K6
Synonyms:	ASK2, MAPKKK6, MEKK6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1288 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. Ref.1 Ref.5
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Magnesium By similarity.
Enzyme regulation	Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct phosphorylation. Ref.1
Subunit structure	Binds both upstream activators and downstream substrates in multimolecular complexes.
Sequence similarities	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 protein kinase domain.
Sequence caution	The sequence AAD05304.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of JUN kinase activity Traceable author statement Ref.5. Source: ProtInc
Molecular_function	ATP binding Inferred from direct assay Ref.5. Source: UniProtKB MAP kinase kinase kinase activity Inferred from direct assay Ref.5. Source: UniProtKB magnesium ion binding Inferred from direct assay Ref.5. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O95382-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O95382-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-277: Missing.
     1065-1074: RLRAQGLGPA → WMNGEDKGSF
     1075-1288: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: O95382-3)

The sequence of this isoform differs from the canonical sequence as follows:
     161-168: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1288	1288	Mitogen-activated protein kinase kinase kinase 6		PRO_0000086251
Regions
	Domain	648 – 906	259	Protein kinase
	Nucleotide binding	654 – 662	9	ATP By similarity
	Coiled coil	1004 – 1029	26	Potential
	Coiled coil	1166 – 1205	40	Potential
Sites
	Active site	771	1	Proton acceptor By similarity
	Binding site	677	1	ATP By similarity
Amino acid modifications
	Modified residue	806	1	Phosphothreonine By similarity
	Modified residue	984	1	Phosphoserine Ref.6 Ref.7 Ref.8
	Modified residue	1129	1	Phosphoserine Ref.6 Ref.8
	Modified residue	1149	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	1 – 277	277	Missing in isoform 2.		VSP_026201
	Alternative sequence	161 – 168	8	Missing in isoform 3.		VSP_026202
	Alternative sequence	1065 – 1074	10	RLRAQGLGPA → WMNGEDKGSF in isoform 2.		VSP_026203
	Alternative sequence	1075 – 1288	214	Missing in isoform 2.		VSP_026204
	Natural variant	455	1	T → I. Ref.1 Ref.3 Corresponds to variant rs1138294 [ dbSNP | Ensembl ].		VAR_032832
	Natural variant	499	1	R → C. Corresponds to variant rs11247641 [ dbSNP | Ensembl ].		VAR_046050
	Natural variant	544	1	R → W. Ref.10 Corresponds to variant rs55671988 [ dbSNP | Ensembl ].		VAR_046051
	Natural variant	622	1	N → K. Ref.4 Ref.10 Corresponds to variant rs35659744 [ dbSNP | Ensembl ].		VAR_032833
	Natural variant	668	1	R → G. Ref.10 Corresponds to variant rs55869163 [ dbSNP | Ensembl ].		VAR_046052
	Natural variant	673	1	R → L. Ref.10 Corresponds to variant rs56359841 [ dbSNP | Ensembl ].		VAR_046053
	Natural variant	869	1	P → T in a breast cancer sample; somatic mutation. Ref.9		VAR_035629
	Natural variant	925	1	S → L in a breast pleomorphic lobular carcinoma sample; somatic mutation. Ref.10		VAR_046054
	Natural variant	968	1	T → I in an ovarian endometrioid cancer sample; somatic mutation. Ref.10		VAR_046055
	Natural variant	969	1	S → N. Ref.3 Corresponds to variant rs17856498 [ dbSNP | Ensembl ].		VAR_032834
	Natural variant	1061	1	A → T. Ref.10 Corresponds to variant rs55990440 [ dbSNP | Ensembl ].		VAR_046056
	Natural variant	1233	1	G → A. Corresponds to variant rs17162549 [ dbSNP | Ensembl ].		VAR_046057
Experimental info
	Sequence conflict	435 – 440	6	MQYYWD → ALWVPV in AAI29952. Ref.3
	Sequence conflict	435 – 440	6	MQYYWD → HTWVPV in AAI29951. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 3, 2009. Version 3. Checksum: 013AF3729698080F	FASTA	1,288	142,596
	10 20 30 40 50 60 MAGPCPRSGA ERAGSCWQDP LAVALSRGRQ LAAPPGRGCA RSRPLSVVYV LTREPQPGLE 70 80 90 100 110 120 PREGTEAEPL PLRCLREACA QVPRPRPPPQ LRSLPFGTLE LGDTAALDAF YNADVVVLEV 130 140 150 160 170 180 SSSLVQPSLF YHLGVRESFS MTNNVLLCSQ ADLPDLQALR EDVFQKNSDC VGSYTLIPYV 190 200 210 220 230 240 VTATGRVLCG DAGLLRGLAD GLVQAGVGTE ALLTPLVGRL ARLLEATPTD SCGYFRETIR 250 260 270 280 290 300 RDIRQARERF SGPQLRQELA RLQRRLDSVE LLSPDIIMNL LLSYRDVQDY SAIIELVETL 310 320 330 340 350 360 QALPTCDVAE QHNVCFHYTF ALNRRNRPGD RAKALSVLLP LVQLEGSVAP DLYCMCGRIY 370 380 390 400 410 420 KDMFFSSGFQ DAGHREQAYH WYRKAFDVEP SLHSGINAAV LLIAAGQHFE DSKELRLIGM 430 440 450 460 470 480 KLGCLLARKG CVEKMQYYWD VGFYLGAQIL ANDPTQVVLA AEQLYKLNAP IWYLVSVMET 490 500 510 520 530 540 FLLYQHFRPT PEPPGGPPRR AHFWLHFLLQ SCQPFKTACA QGDQCLVLVL EMNKVLLPAK 550 560 570 580 590 600 LEVRGTDPVS TVTLSLLEPE TQDIPSSWTF PVASICGVSA SKRDERCCFL YALPPAQDVQ 610 620 630 640 650 660 LCFPSVGHCQ WFCGLIQAWV TNPDSTAPAE EAEGAGEMLE FDYEYTETGE RLVLGKGTYG 670 680 690 700 710 720 VVYAGRDRHT RVRIAIKEIP ERDSRFSQPL HEEIALHRRL RHKNIVRYLG SASQGGYLKI 730 740 750 760 770 780 FMEEVPGGSL SSLLRSVWGP LKDNESTISF YTRQILQGLG YLHDNHIVHR DIKGDNVLIN 790 800 810 820 830 840 TFSGLLKISD FGTSKRLAGI TPCTETFTGT LQYMAPEIID QGPRGYGKAA DIWSLGCTVI 850 860 870 880 890 900 EMATGRPPFH ELGSPQAAMF QVGMYKVHPP MPSSLSAEAQ AFLLRTFEPD PRLRASAQTL 910 920 930 940 950 960 LGDPFLQPGK RSRSPSSPRH APRPSDAPSA SPTPSANSTT QSQTFPCPQA PSQHPPSPPK 970 980 990 1000 1010 1020 RCLSYGGTSQ LRVPEEPAAE EPASPEESSG LSLLHQESKR RAMLAAVLEQ ELPALAENLH 1030 1040 1050 1060 1070 1080 QEQKQEQGAR LGRNHVEELL RCLGAHIHTP NRRQLAQELR ALQGRLRAQG LGPALLHRPL 1090 1100 1110 1120 1130 1140 FAFPDAVKQI LRKRQIRPHW MFVLDSLLSR AVRAALGVLG PEVEKEAVSP RSEELSNEGD 1150 1160 1170 1180 1190 1200 SQQSPGQQSP LPVEPEQGPA PLMVQLSLLR AETDRLREIL AGKEREYQAL VQRALQRLNE 1210 1220 1230 1240 1250 1260 EARTYVLAPE PPTALSTDQG LVQWLQELNV DSGTIQMLLN HSFTLHTLLT YATRDDLIYT 1270 1280 RIRGGMVCRI WRAILAQRAG STPVTSGP
	Isoform 2 [UniParc]. Checksum: 8EA06171D8396464	FASTA	797	88,674
	10 20 30 40 50 60 MNLLLSYRDV QDYSAIIELV ETLQALPTCD VAEQHNVCFH YTFALNRRNR PGDRAKALSV 70 80 90 100 110 120 LLPLVQLEGS VAPDLYCMCG RIYKDMFFSS GFQDAGHREQ AYHWYRKAFD VEPSLHSGIN 130 140 150 160 170 180 AAVLLIAAGQ HFEDSKELRL IGMKLGCLLA RKGCVEKMQY YWDVGFYLGA QILANDPTQV 190 200 210 220 230 240 VLAAEQLYKL NAPIWYLVSV METFLLYQHF RPTPEPPGGP PRRAHFWLHF LLQSCQPFKT 250 260 270 280 290 300 ACAQGDQCLV LVLEMNKVLL PAKLEVRGTD PVSTVTLSLL EPETQDIPSS WTFPVASICG 310 320 330 340 350 360 VSASKRDERC CFLYALPPAQ DVQLCFPSVG HCQWFCGLIQ AWVTNPDSTA PAEEAEGAGE 370 380 390 400 410 420 MLEFDYEYTE TGERLVLGKG TYGVVYAGRD RHTRVRIAIK EIPERDSRFS QPLHEEIALH 430 440 450 460 470 480 RRLRHKNIVR YLGSASQGGY LKIFMEEVPG GSLSSLLRSV WGPLKDNEST ISFYTRQILQ 490 500 510 520 530 540 GLGYLHDNHI VHRDIKGDNV LINTFSGLLK ISDFGTSKRL AGITPCTETF TGTLQYMAPE 550 560 570 580 590 600 IIDQGPRGYG KAADIWSLGC TVIEMATGRP PFHELGSPQA AMFQVGMYKV HPPMPSSLSA 610 620 630 640 650 660 EAQAFLLRTF EPDPRLRASA QTLLGDPFLQ PGKRSRSPSS PRHAPRPSDA PSASPTPSAN 670 680 690 700 710 720 STTQSQTFPC PQAPSQHPPS PPKRCLSYGG TSQLRVPEEP AAEEPASPEE SSGLSLLHQE 730 740 750 760 770 780 SKRRAMLAAV LEQELPALAE NLHQEQKQEQ GARLGRNHVE ELLRCLGAHI HTPNRRQLAQ 790 ELRALQGWMN GEDKGSF
	Isoform 3 [UniParc]. Checksum: C9763EC2F44C5790	FASTA	1,280	141,648
	10 20 30 40 50 60 MAGPCPRSGA ERAGSCWQDP LAVALSRGRQ LAAPPGRGCA RSRPLSVVYV LTREPQPGLE 70 80 90 100 110 120 PREGTEAEPL PLRCLREACA QVPRPRPPPQ LRSLPFGTLE LGDTAALDAF YNADVVVLEV 130 140 150 160 170 180 SSSLVQPSLF YHLGVRESFS MTNNVLLCSQ ADLPDLQALR DCVGSYTLIP YVVTATGRVL 190 200 210 220 230 240 CGDAGLLRGL ADGLVQAGVG TEALLTPLVG RLARLLEATP TDSCGYFRET IRRDIRQARE 250 260 270 280 290 300 RFSGPQLRQE LARLQRRLDS VELLSPDIIM NLLLSYRDVQ DYSAIIELVE TLQALPTCDV 310 320 330 340 350 360 AEQHNVCFHY TFALNRRNRP GDRAKALSVL LPLVQLEGSV APDLYCMCGR IYKDMFFSSG 370 380 390 400 410 420 FQDAGHREQA YHWYRKAFDV EPSLHSGINA AVLLIAAGQH FEDSKELRLI GMKLGCLLAR 430 440 450 460 470 480 KGCVEKMQYY WDVGFYLGAQ ILANDPTQVV LAAEQLYKLN APIWYLVSVM ETFLLYQHFR 490 500 510 520 530 540 PTPEPPGGPP RRAHFWLHFL LQSCQPFKTA CAQGDQCLVL VLEMNKVLLP AKLEVRGTDP 550 560 570 580 590 600 VSTVTLSLLE PETQDIPSSW TFPVASICGV SASKRDERCC FLYALPPAQD VQLCFPSVGH 610 620 630 640 650 660 CQWFCGLIQA WVTNPDSTAP AEEAEGAGEM LEFDYEYTET GERLVLGKGT YGVVYAGRDR 670 680 690 700 710 720 HTRVRIAIKE IPERDSRFSQ PLHEEIALHR RLRHKNIVRY LGSASQGGYL KIFMEEVPGG 730 740 750 760 770 780 SLSSLLRSVW GPLKDNESTI SFYTRQILQG LGYLHDNHIV HRDIKGDNVL INTFSGLLKI 790 800 810 820 830 840 SDFGTSKRLA GITPCTETFT GTLQYMAPEI IDQGPRGYGK AADIWSLGCT VIEMATGRPP 850 860 870 880 890 900 FHELGSPQAA MFQVGMYKVH PPMPSSLSAE AQAFLLRTFE PDPRLRASAQ TLLGDPFLQP 910 920 930 940 950 960 GKRSRSPSSP RHAPRPSDAP SASPTPSANS TTQSQTFPCP QAPSQHPPSP PKRCLSYGGT 970 980 990 1000 1010 1020 SQLRVPEEPA AEEPASPEES SGLSLLHQES KRRAMLAAVL EQELPALAEN LHQEQKQEQG 1030 1040 1050 1060 1070 1080 ARLGRNHVEE LLRCLGAHIH TPNRRQLAQE LRALQGRLRA QGLGPALLHR PLFAFPDAVK 1090 1100 1110 1120 1130 1140 QILRKRQIRP HWMFVLDSLL SRAVRAALGV LGPEVEKEAV SPRSEELSNE GDSQQSPGQQ 1150 1160 1170 1180 1190 1200 SPLPVEPEQG PAPLMVQLSL LRAETDRLRE ILAGKEREYQ ALVQRALQRL NEEARTYVLA 1210 1220 1230 1240 1250 1260 PEPPTALSTD QGLVQWLQEL NVDSGTIQML LNHSFTLHTL LTYATRDDLI YTRIRGGMVC 1270 1280 RIWRAILAQR AGSTPVTSGP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1." Takeda K., Shimozono R., Noguchi T., Umeda T., Morimoto Y., Naguro I., Tobiume K., Saitoh M., Matsuzawa A., Ichijo H. J. Biol. Chem. 282:7522-7531(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME REGULATION, INTERACTION WITH MAP3K5, VARIANT ILE-455.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 435-1288 (ISOFORMS 1/3), VARIANTS ILE-455 AND ASN-969. Tissue: Skin.
[4]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-1288 (ISOFORM 3), VARIANT LYS-622. Tissue: Brain.
[5]	"MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5." Wang X.S., Diener K., Tan T.-H., Yao Z. Biochem. Biophys. Res. Commun. 253:33-37(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 197-1288, FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH MAP3K5.
[6]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-984 AND SER-1129, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-984, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-984; SER-1129 AND SER-1149, MASS SPECTROMETRY.
[9]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-869.
[10]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] TRP-544; LYS-622; GLY-668; LEU-673; LEU-925; ILE-968 AND THR-1061.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB167411 mRNA. Translation: BAD12485.1. AL663123 Genomic DNA. Translation: CAI14778.1. AL663123 Genomic DNA. Translation: CAM12869.1. BC015914 mRNA. Translation: AAH15914.1. BC129950 mRNA. Translation: AAI29951.1. BC129951 mRNA. Translation: AAI29952.1. AB208805 mRNA. Translation: BAD92042.1. AF100318 mRNA. Translation: AAD05304.1. Different initiation.
IPI	IPI00418221. IPI00642537. IPI00847283.
RefSeq	NP_004663.3. NM_004672.3.
UniGene	Hs.194694.
3D structure databases
ProteinModelPortal	O95382.
SMR	O95382. Positions 605-950.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95382. 6 interactions.
STRING	9606.ENSP00000350195.
PTM databases
PhosphoSite	O95382.
Proteomic databases
PaxDb	O95382.
PRIDE	O95382.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000357582; ENSP00000350195; ENSG00000142733. ENST00000374040; ENSP00000363152; ENSG00000142733. ENST00000493901; ENSP00000419591; ENSG00000142733.
GeneID	9064.
KEGG	hsa:9064.
UCSC	uc001bny.1. human. uc001bnz.1. human. uc009vsw.1. human.
Organism-specific databases
CTD	9064.
GeneCards	GC01M027681.
H-InvDB	HIX0000314.
HGNC	HGNC:6858. MAP3K6.
HPA	HPA051192.
MIM	604468. gene.
neXtProt	NX_O95382.
PharmGKB	PA30602.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOVERGEN	HBG006305.
InParanoid	O95382.
KO	K04425.
OMA	KMQYYWD.
PhylomeDB	O95382.
Enzyme and pathway databases
BRENDA	2.7.11.25. 2681.
Pathway_Interaction_DB	p38_mkk3_6pathway. p38 MAPK signaling pathway.
Gene expression databases
ArrayExpress	O95382.
Bgee	O95382.
CleanEx	HS_MAP3K6.
Genevestigator	O95382.
GermOnline	ENSG00000142733. Homo sapiens.
Family and domain databases
InterPro	IPR025136. DUF4071. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR013761. SAM/pointed. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF13281. DUF4071. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF47769. SAM_homology. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	O95382.
ChEMBL	CHEMBL1163123.
GenomeRNAi	9064.
NextBio	33967.
SOURCE	Search...

Entry information

Entry name

M3K6_HUMAN

Accession

Primary (citable) accession number: O95382
Secondary accession number(s): A2ACE8 , A2VDG4, A2VDG5, Q59HF4, Q5SSD4, Q75PK3, Q96B75

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 3, 2009
Last modified:	May 1, 2013
This is version 120 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.