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O95382

- M3K6_HUMAN

UniProt

O95382 - M3K6_HUMAN

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Protein

Mitogen-activated protein kinase kinase kinase 6

Gene

MAP3K6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium.By similarity

Enzyme regulationi

Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct phosphorylation.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei677 – 6771ATPPROSITE-ProRule annotation
Active sitei771 – 7711Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi654 – 6629ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. magnesium ion binding Source: UniProtKB
  3. MAP kinase kinase kinase activity Source: UniProtKB

GO - Biological processi

  1. activation of JUN kinase activity Source: ProtInc
  2. activation of MAPKK activity Source: GOC
  3. protein phosphorylation Source: UniProtKB
  4. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.25. 2681.
SignaLinkiO95382.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 6 (EC:2.7.11.25)
Alternative name(s):
Apoptosis signal-regulating kinase 2
Gene namesi
Name:MAP3K6
Synonyms:ASK2, MAPKKK6, MEKK6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:6858. MAP3K6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30602.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12881288Mitogen-activated protein kinase kinase kinase 6PRO_0000086251Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei806 – 8061PhosphothreonineBy similarity
Modified residuei984 – 9841Phosphoserine3 Publications
Modified residuei1129 – 11291Phosphoserine2 Publications
Modified residuei1149 – 11491Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO95382.
PaxDbiO95382.
PRIDEiO95382.

PTM databases

PhosphoSiteiO95382.

Expressioni

Gene expression databases

BgeeiO95382.
CleanExiHS_MAP3K6.
ExpressionAtlasiO95382. baseline and differential.
GenevestigatoriO95382.

Organism-specific databases

HPAiHPA051192.

Interactioni

Subunit structurei

Binds both upstream activators and downstream substrates in multimolecular complexes.

Protein-protein interaction databases

BioGridi114524. 7 interactions.
IntActiO95382. 7 interactions.
MINTiMINT-7997495.
STRINGi9606.ENSP00000350195.

Structurei

3D structure databases

ProteinModelPortaliO95382.
SMRiO95382. Positions 605-950.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini648 – 906259Protein kinasePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1004 – 102926Sequence AnalysisAdd
BLAST
Coiled coili1166 – 120540Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119077.
HOVERGENiHBG006305.
InParanoidiO95382.
KOiK04425.
OMAiKMQYYWD.
PhylomeDBiO95382.
TreeFamiTF105115.

Family and domain databases

InterProiIPR025136. DUF4071.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR013761. SAM/pointed.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF13281. DUF4071. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95382-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGPCPRSGA ERAGSCWQDP LAVALSRGRQ LAAPPGRGCA RSRPLSVVYV
60 70 80 90 100
LTREPQPGLE PREGTEAEPL PLRCLREACA QVPRPRPPPQ LRSLPFGTLE
110 120 130 140 150
LGDTAALDAF YNADVVVLEV SSSLVQPSLF YHLGVRESFS MTNNVLLCSQ
160 170 180 190 200
ADLPDLQALR EDVFQKNSDC VGSYTLIPYV VTATGRVLCG DAGLLRGLAD
210 220 230 240 250
GLVQAGVGTE ALLTPLVGRL ARLLEATPTD SCGYFRETIR RDIRQARERF
260 270 280 290 300
SGPQLRQELA RLQRRLDSVE LLSPDIIMNL LLSYRDVQDY SAIIELVETL
310 320 330 340 350
QALPTCDVAE QHNVCFHYTF ALNRRNRPGD RAKALSVLLP LVQLEGSVAP
360 370 380 390 400
DLYCMCGRIY KDMFFSSGFQ DAGHREQAYH WYRKAFDVEP SLHSGINAAV
410 420 430 440 450
LLIAAGQHFE DSKELRLIGM KLGCLLARKG CVEKMQYYWD VGFYLGAQIL
460 470 480 490 500
ANDPTQVVLA AEQLYKLNAP IWYLVSVMET FLLYQHFRPT PEPPGGPPRR
510 520 530 540 550
AHFWLHFLLQ SCQPFKTACA QGDQCLVLVL EMNKVLLPAK LEVRGTDPVS
560 570 580 590 600
TVTLSLLEPE TQDIPSSWTF PVASICGVSA SKRDERCCFL YALPPAQDVQ
610 620 630 640 650
LCFPSVGHCQ WFCGLIQAWV TNPDSTAPAE EAEGAGEMLE FDYEYTETGE
660 670 680 690 700
RLVLGKGTYG VVYAGRDRHT RVRIAIKEIP ERDSRFSQPL HEEIALHRRL
710 720 730 740 750
RHKNIVRYLG SASQGGYLKI FMEEVPGGSL SSLLRSVWGP LKDNESTISF
760 770 780 790 800
YTRQILQGLG YLHDNHIVHR DIKGDNVLIN TFSGLLKISD FGTSKRLAGI
810 820 830 840 850
TPCTETFTGT LQYMAPEIID QGPRGYGKAA DIWSLGCTVI EMATGRPPFH
860 870 880 890 900
ELGSPQAAMF QVGMYKVHPP MPSSLSAEAQ AFLLRTFEPD PRLRASAQTL
910 920 930 940 950
LGDPFLQPGK RSRSPSSPRH APRPSDAPSA SPTPSANSTT QSQTFPCPQA
960 970 980 990 1000
PSQHPPSPPK RCLSYGGTSQ LRVPEEPAAE EPASPEESSG LSLLHQESKR
1010 1020 1030 1040 1050
RAMLAAVLEQ ELPALAENLH QEQKQEQGAR LGRNHVEELL RCLGAHIHTP
1060 1070 1080 1090 1100
NRRQLAQELR ALQGRLRAQG LGPALLHRPL FAFPDAVKQI LRKRQIRPHW
1110 1120 1130 1140 1150
MFVLDSLLSR AVRAALGVLG PEVEKEAVSP RSEELSNEGD SQQSPGQQSP
1160 1170 1180 1190 1200
LPVEPEQGPA PLMVQLSLLR AETDRLREIL AGKEREYQAL VQRALQRLNE
1210 1220 1230 1240 1250
EARTYVLAPE PPTALSTDQG LVQWLQELNV DSGTIQMLLN HSFTLHTLLT
1260 1270 1280
YATRDDLIYT RIRGGMVCRI WRAILAQRAG STPVTSGP
Length:1,288
Mass (Da):142,596
Last modified:November 3, 2009 - v3
Checksum:i013AF3729698080F
GO
Isoform 2 (identifier: O95382-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-277: Missing.
     1065-1074: RLRAQGLGPA → WMNGEDKGSF
     1075-1288: Missing.

Note: No experimental confirmation available.

Show »
Length:797
Mass (Da):88,674
Checksum:i8EA06171D8396464
GO
Isoform 3 (identifier: O95382-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-168: Missing.

Note: No experimental confirmation available.

Show »
Length:1,280
Mass (Da):141,648
Checksum:iC9763EC2F44C5790
GO

Sequence cautioni

The sequence AAD05304.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti435 – 4406MQYYWD → ALWVPV in AAI29952. (PubMed:15489334)Curated
Sequence conflicti435 – 4406MQYYWD → HTWVPV in AAI29951. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti455 – 4551T → I.2 Publications
Corresponds to variant rs1138294 [ dbSNP | Ensembl ].
VAR_032832
Natural varianti499 – 4991R → C.
Corresponds to variant rs11247641 [ dbSNP | Ensembl ].
VAR_046050
Natural varianti544 – 5441R → W.1 Publication
Corresponds to variant rs55671988 [ dbSNP | Ensembl ].
VAR_046051
Natural varianti622 – 6221N → K.2 Publications
Corresponds to variant rs35659744 [ dbSNP | Ensembl ].
VAR_032833
Natural varianti668 – 6681R → G.1 Publication
Corresponds to variant rs55869163 [ dbSNP | Ensembl ].
VAR_046052
Natural varianti673 – 6731R → L.1 Publication
Corresponds to variant rs56359841 [ dbSNP | Ensembl ].
VAR_046053
Natural varianti869 – 8691P → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_035629
Natural varianti925 – 9251S → L in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication
VAR_046054
Natural varianti968 – 9681T → I in an ovarian endometrioid cancer sample; somatic mutation. 1 Publication
VAR_046055
Natural varianti969 – 9691S → N.1 Publication
Corresponds to variant rs17856498 [ dbSNP | Ensembl ].
VAR_032834
Natural varianti1061 – 10611A → T.1 Publication
Corresponds to variant rs55990440 [ dbSNP | Ensembl ].
VAR_046056
Natural varianti1233 – 12331G → A.
Corresponds to variant rs17162549 [ dbSNP | Ensembl ].
VAR_046057

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 277277Missing in isoform 2. 1 PublicationVSP_026201Add
BLAST
Alternative sequencei161 – 1688Missing in isoform 3. 1 PublicationVSP_026202
Alternative sequencei1065 – 107410RLRAQGLGPA → WMNGEDKGSF in isoform 2. 1 PublicationVSP_026203
Alternative sequencei1075 – 1288214Missing in isoform 2. 1 PublicationVSP_026204Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB167411 mRNA. Translation: BAD12485.1.
FO393419 Genomic DNA. No translation available.
BC015914 mRNA. Translation: AAH15914.1.
BC129950 mRNA. Translation: AAI29951.1.
BC129951 mRNA. Translation: AAI29952.1.
AB208805 mRNA. Translation: BAD92042.1.
AF100318 mRNA. Translation: AAD05304.1. Different initiation.
CCDSiCCDS299.1. [O95382-1]
CCDS72738.1. [O95382-3]
RefSeqiNP_001284538.1. NM_001297609.1. [O95382-3]
NP_004663.3. NM_004672.4. [O95382-1]
UniGeneiHs.194694.

Genome annotation databases

EnsembliENST00000357582; ENSP00000350195; ENSG00000142733. [O95382-1]
ENST00000374040; ENSP00000363152; ENSG00000142733. [O95382-3]
ENST00000493901; ENSP00000419591; ENSG00000142733. [O95382-1]
GeneIDi9064.
KEGGihsa:9064.
UCSCiuc001bny.1. human. [O95382-1]
uc001bnz.1. human. [O95382-2]
uc009vsw.1. human. [O95382-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB167411 mRNA. Translation: BAD12485.1 .
FO393419 Genomic DNA. No translation available.
BC015914 mRNA. Translation: AAH15914.1 .
BC129950 mRNA. Translation: AAI29951.1 .
BC129951 mRNA. Translation: AAI29952.1 .
AB208805 mRNA. Translation: BAD92042.1 .
AF100318 mRNA. Translation: AAD05304.1 . Different initiation.
CCDSi CCDS299.1. [O95382-1 ]
CCDS72738.1. [O95382-3 ]
RefSeqi NP_001284538.1. NM_001297609.1. [O95382-3 ]
NP_004663.3. NM_004672.4. [O95382-1 ]
UniGenei Hs.194694.

3D structure databases

ProteinModelPortali O95382.
SMRi O95382. Positions 605-950.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114524. 7 interactions.
IntActi O95382. 7 interactions.
MINTi MINT-7997495.
STRINGi 9606.ENSP00000350195.

Chemistry

BindingDBi O95382.
ChEMBLi CHEMBL1163123.
GuidetoPHARMACOLOGYi 2081.

PTM databases

PhosphoSitei O95382.

Proteomic databases

MaxQBi O95382.
PaxDbi O95382.
PRIDEi O95382.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357582 ; ENSP00000350195 ; ENSG00000142733 . [O95382-1 ]
ENST00000374040 ; ENSP00000363152 ; ENSG00000142733 . [O95382-3 ]
ENST00000493901 ; ENSP00000419591 ; ENSG00000142733 . [O95382-1 ]
GeneIDi 9064.
KEGGi hsa:9064.
UCSCi uc001bny.1. human. [O95382-1 ]
uc001bnz.1. human. [O95382-2 ]
uc009vsw.1. human. [O95382-3 ]

Organism-specific databases

CTDi 9064.
GeneCardsi GC01M027681.
H-InvDB HIX0000314.
HGNCi HGNC:6858. MAP3K6.
HPAi HPA051192.
MIMi 604468. gene.
neXtProti NX_O95382.
PharmGKBi PA30602.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119077.
HOVERGENi HBG006305.
InParanoidi O95382.
KOi K04425.
OMAi KMQYYWD.
PhylomeDBi O95382.
TreeFami TF105115.

Enzyme and pathway databases

BRENDAi 2.7.11.25. 2681.
SignaLinki O95382.

Miscellaneous databases

GenomeRNAii 9064.
NextBioi 33967.
PROi O95382.
SOURCEi Search...

Gene expression databases

Bgeei O95382.
CleanExi HS_MAP3K6.
ExpressionAtlasi O95382. baseline and differential.
Genevestigatori O95382.

Family and domain databases

InterProi IPR025136. DUF4071.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR013761. SAM/pointed.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF13281. DUF4071. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1."
    Takeda K., Shimozono R., Noguchi T., Umeda T., Morimoto Y., Naguro I., Tobiume K., Saitoh M., Matsuzawa A., Ichijo H.
    J. Biol. Chem. 282:7522-7531(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME REGULATION, INTERACTION WITH MAP3K5, VARIANT ILE-455.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 435-1288 (ISOFORMS 1/3), VARIANTS ILE-455 AND ASN-969.
    Tissue: Skin.
  4. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-1288 (ISOFORM 3), VARIANT LYS-622.
    Tissue: Brain.
  5. "MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5."
    Wang X.S., Diener K., Tan T.-H., Yao Z.
    Biochem. Biophys. Res. Commun. 253:33-37(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 197-1288, FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH MAP3K5.
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-984 AND SER-1129, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-984, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-984; SER-1129 AND SER-1149, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-869.
  10. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] TRP-544; LYS-622; GLY-668; LEU-673; LEU-925; ILE-968 AND THR-1061.

Entry informationi

Entry nameiM3K6_HUMAN
AccessioniPrimary (citable) accession number: O95382
Secondary accession number(s): A2ACE8
, A2VDG4, A2VDG5, Q59HF4, Q5SSD4, Q75PK3, Q96B75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 3, 2009
Last modified: October 29, 2014
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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