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O95382

- M3K6_HUMAN

UniProt

O95382 - M3K6_HUMAN

Protein

Mitogen-activated protein kinase kinase kinase 6

Gene

MAP3K6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 3 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.2 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct phosphorylation.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei677 – 6771ATPPROSITE-ProRule annotation
    Active sitei771 – 7711Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi654 – 6629ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. magnesium ion binding Source: UniProtKB
    3. MAP kinase kinase kinase activity Source: UniProtKB

    GO - Biological processi

    1. activation of JUN kinase activity Source: ProtInc
    2. activation of MAPKK activity Source: GOC
    3. protein phosphorylation Source: UniProtKB
    4. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.25. 2681.
    SignaLinkiO95382.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 6 (EC:2.7.11.25)
    Alternative name(s):
    Apoptosis signal-regulating kinase 2
    Gene namesi
    Name:MAP3K6
    Synonyms:ASK2, MAPKKK6, MEKK6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:6858. MAP3K6.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30602.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12881288Mitogen-activated protein kinase kinase kinase 6PRO_0000086251Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei806 – 8061PhosphothreonineBy similarity
    Modified residuei984 – 9841Phosphoserine3 Publications
    Modified residuei1129 – 11291Phosphoserine2 Publications
    Modified residuei1149 – 11491Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO95382.
    PaxDbiO95382.
    PRIDEiO95382.

    PTM databases

    PhosphoSiteiO95382.

    Expressioni

    Gene expression databases

    ArrayExpressiO95382.
    BgeeiO95382.
    CleanExiHS_MAP3K6.
    GenevestigatoriO95382.

    Organism-specific databases

    HPAiHPA051192.

    Interactioni

    Subunit structurei

    Binds both upstream activators and downstream substrates in multimolecular complexes.

    Protein-protein interaction databases

    BioGridi114524. 5 interactions.
    IntActiO95382. 7 interactions.
    MINTiMINT-7997495.
    STRINGi9606.ENSP00000350195.

    Structurei

    3D structure databases

    ProteinModelPortaliO95382.
    SMRiO95382. Positions 605-950.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini648 – 906259Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1004 – 102926Sequence AnalysisAdd
    BLAST
    Coiled coili1166 – 120540Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG0515.
    HOVERGENiHBG006305.
    InParanoidiO95382.
    KOiK04425.
    OMAiKMQYYWD.
    PhylomeDBiO95382.
    TreeFamiTF105115.

    Family and domain databases

    InterProiIPR025136. DUF4071.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR013761. SAM/pointed.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF13281. DUF4071. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95382-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGPCPRSGA ERAGSCWQDP LAVALSRGRQ LAAPPGRGCA RSRPLSVVYV     50
    LTREPQPGLE PREGTEAEPL PLRCLREACA QVPRPRPPPQ LRSLPFGTLE 100
    LGDTAALDAF YNADVVVLEV SSSLVQPSLF YHLGVRESFS MTNNVLLCSQ 150
    ADLPDLQALR EDVFQKNSDC VGSYTLIPYV VTATGRVLCG DAGLLRGLAD 200
    GLVQAGVGTE ALLTPLVGRL ARLLEATPTD SCGYFRETIR RDIRQARERF 250
    SGPQLRQELA RLQRRLDSVE LLSPDIIMNL LLSYRDVQDY SAIIELVETL 300
    QALPTCDVAE QHNVCFHYTF ALNRRNRPGD RAKALSVLLP LVQLEGSVAP 350
    DLYCMCGRIY KDMFFSSGFQ DAGHREQAYH WYRKAFDVEP SLHSGINAAV 400
    LLIAAGQHFE DSKELRLIGM KLGCLLARKG CVEKMQYYWD VGFYLGAQIL 450
    ANDPTQVVLA AEQLYKLNAP IWYLVSVMET FLLYQHFRPT PEPPGGPPRR 500
    AHFWLHFLLQ SCQPFKTACA QGDQCLVLVL EMNKVLLPAK LEVRGTDPVS 550
    TVTLSLLEPE TQDIPSSWTF PVASICGVSA SKRDERCCFL YALPPAQDVQ 600
    LCFPSVGHCQ WFCGLIQAWV TNPDSTAPAE EAEGAGEMLE FDYEYTETGE 650
    RLVLGKGTYG VVYAGRDRHT RVRIAIKEIP ERDSRFSQPL HEEIALHRRL 700
    RHKNIVRYLG SASQGGYLKI FMEEVPGGSL SSLLRSVWGP LKDNESTISF 750
    YTRQILQGLG YLHDNHIVHR DIKGDNVLIN TFSGLLKISD FGTSKRLAGI 800
    TPCTETFTGT LQYMAPEIID QGPRGYGKAA DIWSLGCTVI EMATGRPPFH 850
    ELGSPQAAMF QVGMYKVHPP MPSSLSAEAQ AFLLRTFEPD PRLRASAQTL 900
    LGDPFLQPGK RSRSPSSPRH APRPSDAPSA SPTPSANSTT QSQTFPCPQA 950
    PSQHPPSPPK RCLSYGGTSQ LRVPEEPAAE EPASPEESSG LSLLHQESKR 1000
    RAMLAAVLEQ ELPALAENLH QEQKQEQGAR LGRNHVEELL RCLGAHIHTP 1050
    NRRQLAQELR ALQGRLRAQG LGPALLHRPL FAFPDAVKQI LRKRQIRPHW 1100
    MFVLDSLLSR AVRAALGVLG PEVEKEAVSP RSEELSNEGD SQQSPGQQSP 1150
    LPVEPEQGPA PLMVQLSLLR AETDRLREIL AGKEREYQAL VQRALQRLNE 1200
    EARTYVLAPE PPTALSTDQG LVQWLQELNV DSGTIQMLLN HSFTLHTLLT 1250
    YATRDDLIYT RIRGGMVCRI WRAILAQRAG STPVTSGP 1288
    Length:1,288
    Mass (Da):142,596
    Last modified:November 3, 2009 - v3
    Checksum:i013AF3729698080F
    GO
    Isoform 2 (identifier: O95382-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-277: Missing.
         1065-1074: RLRAQGLGPA → WMNGEDKGSF
         1075-1288: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:797
    Mass (Da):88,674
    Checksum:i8EA06171D8396464
    GO
    Isoform 3 (identifier: O95382-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         161-168: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,280
    Mass (Da):141,648
    Checksum:iC9763EC2F44C5790
    GO

    Sequence cautioni

    The sequence AAD05304.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti435 – 4406MQYYWD → ALWVPV in AAI29952. (PubMed:15489334)Curated
    Sequence conflicti435 – 4406MQYYWD → HTWVPV in AAI29951. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti455 – 4551T → I.2 Publications
    Corresponds to variant rs1138294 [ dbSNP | Ensembl ].
    VAR_032832
    Natural varianti499 – 4991R → C.
    Corresponds to variant rs11247641 [ dbSNP | Ensembl ].
    VAR_046050
    Natural varianti544 – 5441R → W.1 Publication
    Corresponds to variant rs55671988 [ dbSNP | Ensembl ].
    VAR_046051
    Natural varianti622 – 6221N → K.2 Publications
    Corresponds to variant rs35659744 [ dbSNP | Ensembl ].
    VAR_032833
    Natural varianti668 – 6681R → G.1 Publication
    Corresponds to variant rs55869163 [ dbSNP | Ensembl ].
    VAR_046052
    Natural varianti673 – 6731R → L.1 Publication
    Corresponds to variant rs56359841 [ dbSNP | Ensembl ].
    VAR_046053
    Natural varianti869 – 8691P → T in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035629
    Natural varianti925 – 9251S → L in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication
    VAR_046054
    Natural varianti968 – 9681T → I in an ovarian endometrioid cancer sample; somatic mutation. 1 Publication
    VAR_046055
    Natural varianti969 – 9691S → N.1 Publication
    Corresponds to variant rs17856498 [ dbSNP | Ensembl ].
    VAR_032834
    Natural varianti1061 – 10611A → T.1 Publication
    Corresponds to variant rs55990440 [ dbSNP | Ensembl ].
    VAR_046056
    Natural varianti1233 – 12331G → A.
    Corresponds to variant rs17162549 [ dbSNP | Ensembl ].
    VAR_046057

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 277277Missing in isoform 2. 1 PublicationVSP_026201Add
    BLAST
    Alternative sequencei161 – 1688Missing in isoform 3. 1 PublicationVSP_026202
    Alternative sequencei1065 – 107410RLRAQGLGPA → WMNGEDKGSF in isoform 2. 1 PublicationVSP_026203
    Alternative sequencei1075 – 1288214Missing in isoform 2. 1 PublicationVSP_026204Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB167411 mRNA. Translation: BAD12485.1.
    FO393419 Genomic DNA. No translation available.
    BC015914 mRNA. Translation: AAH15914.1.
    BC129950 mRNA. Translation: AAI29951.1.
    BC129951 mRNA. Translation: AAI29952.1.
    AB208805 mRNA. Translation: BAD92042.1.
    AF100318 mRNA. Translation: AAD05304.1. Different initiation.
    CCDSiCCDS299.1. [O95382-1]
    RefSeqiNP_004663.3. NM_004672.3. [O95382-1]
    XP_005246086.1. XM_005246029.2. [O95382-3]
    UniGeneiHs.194694.

    Genome annotation databases

    EnsembliENST00000357582; ENSP00000350195; ENSG00000142733. [O95382-1]
    ENST00000374040; ENSP00000363152; ENSG00000142733. [O95382-3]
    ENST00000493901; ENSP00000419591; ENSG00000142733. [O95382-1]
    GeneIDi9064.
    KEGGihsa:9064.
    UCSCiuc001bny.1. human. [O95382-1]
    uc001bnz.1. human. [O95382-2]
    uc009vsw.1. human. [O95382-3]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB167411 mRNA. Translation: BAD12485.1 .
    FO393419 Genomic DNA. No translation available.
    BC015914 mRNA. Translation: AAH15914.1 .
    BC129950 mRNA. Translation: AAI29951.1 .
    BC129951 mRNA. Translation: AAI29952.1 .
    AB208805 mRNA. Translation: BAD92042.1 .
    AF100318 mRNA. Translation: AAD05304.1 . Different initiation.
    CCDSi CCDS299.1. [O95382-1 ]
    RefSeqi NP_004663.3. NM_004672.3. [O95382-1 ]
    XP_005246086.1. XM_005246029.2. [O95382-3 ]
    UniGenei Hs.194694.

    3D structure databases

    ProteinModelPortali O95382.
    SMRi O95382. Positions 605-950.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114524. 5 interactions.
    IntActi O95382. 7 interactions.
    MINTi MINT-7997495.
    STRINGi 9606.ENSP00000350195.

    Chemistry

    BindingDBi O95382.
    ChEMBLi CHEMBL1163123.
    GuidetoPHARMACOLOGYi 2081.

    PTM databases

    PhosphoSitei O95382.

    Proteomic databases

    MaxQBi O95382.
    PaxDbi O95382.
    PRIDEi O95382.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357582 ; ENSP00000350195 ; ENSG00000142733 . [O95382-1 ]
    ENST00000374040 ; ENSP00000363152 ; ENSG00000142733 . [O95382-3 ]
    ENST00000493901 ; ENSP00000419591 ; ENSG00000142733 . [O95382-1 ]
    GeneIDi 9064.
    KEGGi hsa:9064.
    UCSCi uc001bny.1. human. [O95382-1 ]
    uc001bnz.1. human. [O95382-2 ]
    uc009vsw.1. human. [O95382-3 ]

    Organism-specific databases

    CTDi 9064.
    GeneCardsi GC01M027681.
    H-InvDB HIX0000314.
    HGNCi HGNC:6858. MAP3K6.
    HPAi HPA051192.
    MIMi 604468. gene.
    neXtProti NX_O95382.
    PharmGKBi PA30602.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOVERGENi HBG006305.
    InParanoidi O95382.
    KOi K04425.
    OMAi KMQYYWD.
    PhylomeDBi O95382.
    TreeFami TF105115.

    Enzyme and pathway databases

    BRENDAi 2.7.11.25. 2681.
    SignaLinki O95382.

    Miscellaneous databases

    GenomeRNAii 9064.
    NextBioi 33967.
    PROi O95382.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95382.
    Bgeei O95382.
    CleanExi HS_MAP3K6.
    Genevestigatori O95382.

    Family and domain databases

    InterProi IPR025136. DUF4071.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR013761. SAM/pointed.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF13281. DUF4071. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1."
      Takeda K., Shimozono R., Noguchi T., Umeda T., Morimoto Y., Naguro I., Tobiume K., Saitoh M., Matsuzawa A., Ichijo H.
      J. Biol. Chem. 282:7522-7531(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME REGULATION, INTERACTION WITH MAP3K5, VARIANT ILE-455.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 435-1288 (ISOFORMS 1/3), VARIANTS ILE-455 AND ASN-969.
      Tissue: Skin.
    4. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-1288 (ISOFORM 3), VARIANT LYS-622.
      Tissue: Brain.
    5. "MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5."
      Wang X.S., Diener K., Tan T.-H., Yao Z.
      Biochem. Biophys. Res. Commun. 253:33-37(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 197-1288, FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH MAP3K5.
    6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-984 AND SER-1129, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-984, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-984; SER-1129 AND SER-1149, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-869.
    10. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] TRP-544; LYS-622; GLY-668; LEU-673; LEU-925; ILE-968 AND THR-1061.

    Entry informationi

    Entry nameiM3K6_HUMAN
    AccessioniPrimary (citable) accession number: O95382
    Secondary accession number(s): A2ACE8
    , A2VDG4, A2VDG5, Q59HF4, Q5SSD4, Q75PK3, Q96B75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 133 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3