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O95379

- TFIP8_HUMAN

UniProt

O95379 - TFIP8_HUMAN

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Protein

Tumor necrosis factor alpha-induced protein 8

Gene

TNFAIP8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.3 Publications

GO - Molecular functioni

  1. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB

GO - Biological processi

  1. defense response to Gram-positive bacterium Source: Ensembl
  2. interleukin-1 beta production Source: Ensembl
  3. negative regulation of apoptotic process Source: ProtInc
  4. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: GOC
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor alpha-induced protein 8
Short name:
TNF alpha-induced protein 8
Alternative name(s):
Head and neck tumor and metastasis-related protein
MDC-3.13
NF-kappa-B-inducible DED-containing protein
Short name:
NDED
SCC-S2
TNF-induced protein GG2-1
Gene namesi
Name:TNFAIP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:17260. TNFAIP8.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134957136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Tumor necrosis factor alpha-induced protein 8PRO_0000285718Add
BLAST

Proteomic databases

MaxQBiO95379.
PaxDbiO95379.
PRIDEiO95379.

Expressioni

Tissue specificityi

Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.3 Publications

Developmental stagei

Expressed at high levels in the fetal liver, lung and kidney.1 Publication

Inductioni

By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB.2 Publications

Gene expression databases

BgeeiO95379.
CleanExiHS_TNFAIP8.
ExpressionAtlasiO95379. baseline and differential.
GenevestigatoriO95379.

Organism-specific databases

HPAiHPA057089.

Interactioni

Protein-protein interaction databases

BioGridi117344. 14 interactions.
IntActiO95379. 2 interactions.
MINTiMINT-1473332.
STRINGi9606.ENSP00000408534.

Structurei

3D structure databases

ProteinModelPortaliO95379.
SMRiO95379. Positions 43-195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili49 – 8335Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TNFAIP8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG81900.
GeneTreeiENSGT00390000003488.
HOGENOMiHOG000007708.
HOVERGENiHBG053286.
InParanoidiO95379.
OrthoDBiEOG7P5T2H.
PhylomeDBiO95379.
TreeFamiTF323415.

Family and domain databases

InterProiIPR008477. DUF758.
[Graphical view]
PANTHERiPTHR12757. PTHR12757. 1 hit.
PfamiPF05527. DUF758. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95379-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHSEAEESKE VATDVFNSKN LAVQAQKKIL GKMVSKSIAT TLIDDTSSEV
60 70 80 90 100
LDELYRVTRE YTQNKKEAEK IIKNLIKTVI KLAILYRNNQ FNQDELALME
110 120 130 140 150
KFKKKVHQLA MTVVSFHQVD YTFDRNVLSR LLNECREMLH QIIQRHLTAK
160 170 180 190
SHGRVNNVFD HFSDCEFLAA LYNPFGNFKP HLQKLCDGIN KMLDEENI
Length:198
Mass (Da):23,003
Last modified:May 1, 1999 - v1
Checksum:iD9B8F6FCF9AFC2C3
GO
Isoform 2 (identifier: O95379-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MHSEAEESKE → MA

Show »
Length:190
Mass (Da):22,048
Checksum:i0DCD250217A1209C
GO
Isoform 3 (identifier: O95379-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MHSEAEESKEV → M

Show »
Length:188
Mass (Da):21,877
Checksum:i60452EC0A684F535
GO
Isoform 4 (identifier: O95379-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MHSEAEESKE → MTLPRYCEVVLLIAHGEKMLKL

Note: No experimental confirmation available.

Show »
Length:210
Mass (Da):24,385
Checksum:i44DE8FBED9290476
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti151 – 1511S → C.
Corresponds to variant rs3203922 [ dbSNP | Ensembl ].
VAR_032047

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1111MHSEAEESKEV → M in isoform 3. 3 PublicationsVSP_024898Add
BLAST
Alternative sequencei1 – 1010MHSEAEESKE → MA in isoform 2. 2 PublicationsVSP_024899
Alternative sequencei1 – 1010MHSEAEESKE → MTLPRYCEVVLLIAHGEKML KL in isoform 4. 1 PublicationVSP_054827

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070671 mRNA. Translation: AAC83229.1.
AF099935 mRNA. Translation: AAC72975.1.
AF099936 mRNA. Translation: AAC72976.1.
CR457137 mRNA. Translation: CAG33418.1.
AK001850 mRNA. Translation: BAG50983.1.
AK001931 mRNA. Translation: BAG50994.1.
AK301281 mRNA. Translation: BAH13449.1.
AC008475 Genomic DNA. No translation available.
AC027320 Genomic DNA. No translation available.
AC035144 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW48914.1.
BC005352 mRNA. Translation: AAH05352.1.
BC007014 mRNA. Translation: AAH07014.1.
AF098933 mRNA. Translation: AAF29435.1.
CCDSiCCDS47257.1. [O95379-3]
CCDS47258.1. [O95379-1]
CCDS68933.1. [O95379-4]
RefSeqiNP_001071122.1. NM_001077654.2. [O95379-3]
NP_001273742.1. NM_001286813.1. [O95379-1]
NP_001273743.1. NM_001286814.1. [O95379-4]
NP_001273744.1. NM_001286815.1.
NP_001273746.1. NM_001286817.1.
NP_055165.2. NM_014350.3. [O95379-1]
UniGeneiHs.618488.
Hs.656274.

Genome annotation databases

EnsembliENST00000274456; ENSP00000274456; ENSG00000145779. [O95379-3]
ENST00000503646; ENSP00000421848; ENSG00000145779. [O95379-1]
ENST00000504771; ENSP00000422245; ENSG00000145779. [O95379-1]
ENST00000513374; ENSP00000427424; ENSG00000145779. [O95379-4]
GeneIDi25816.
KEGGihsa:25816.
UCSCiuc003ksg.3. human. [O95379-3]
uc003ksi.3. human. [O95379-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070671 mRNA. Translation: AAC83229.1 .
AF099935 mRNA. Translation: AAC72975.1 .
AF099936 mRNA. Translation: AAC72976.1 .
CR457137 mRNA. Translation: CAG33418.1 .
AK001850 mRNA. Translation: BAG50983.1 .
AK001931 mRNA. Translation: BAG50994.1 .
AK301281 mRNA. Translation: BAH13449.1 .
AC008475 Genomic DNA. No translation available.
AC027320 Genomic DNA. No translation available.
AC035144 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW48914.1 .
BC005352 mRNA. Translation: AAH05352.1 .
BC007014 mRNA. Translation: AAH07014.1 .
AF098933 mRNA. Translation: AAF29435.1 .
CCDSi CCDS47257.1. [O95379-3 ]
CCDS47258.1. [O95379-1 ]
CCDS68933.1. [O95379-4 ]
RefSeqi NP_001071122.1. NM_001077654.2. [O95379-3 ]
NP_001273742.1. NM_001286813.1. [O95379-1 ]
NP_001273743.1. NM_001286814.1. [O95379-4 ]
NP_001273744.1. NM_001286815.1.
NP_001273746.1. NM_001286817.1.
NP_055165.2. NM_014350.3. [O95379-1 ]
UniGenei Hs.618488.
Hs.656274.

3D structure databases

ProteinModelPortali O95379.
SMRi O95379. Positions 43-195.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117344. 14 interactions.
IntActi O95379. 2 interactions.
MINTi MINT-1473332.
STRINGi 9606.ENSP00000408534.

Proteomic databases

MaxQBi O95379.
PaxDbi O95379.
PRIDEi O95379.

Protocols and materials databases

DNASUi 25816.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000274456 ; ENSP00000274456 ; ENSG00000145779 . [O95379-3 ]
ENST00000503646 ; ENSP00000421848 ; ENSG00000145779 . [O95379-1 ]
ENST00000504771 ; ENSP00000422245 ; ENSG00000145779 . [O95379-1 ]
ENST00000513374 ; ENSP00000427424 ; ENSG00000145779 . [O95379-4 ]
GeneIDi 25816.
KEGGi hsa:25816.
UCSCi uc003ksg.3. human. [O95379-3 ]
uc003ksi.3. human. [O95379-1 ]

Organism-specific databases

CTDi 25816.
GeneCardsi GC05P118604.
H-InvDB HIX0005115.
HGNCi HGNC:17260. TNFAIP8.
HPAi HPA057089.
MIMi 612111. gene.
neXtProti NX_O95379.
PharmGKBi PA134957136.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG81900.
GeneTreei ENSGT00390000003488.
HOGENOMi HOG000007708.
HOVERGENi HBG053286.
InParanoidi O95379.
OrthoDBi EOG7P5T2H.
PhylomeDBi O95379.
TreeFami TF323415.

Miscellaneous databases

ChiTaRSi TNFAIP8. human.
GeneWikii TNFAIP8.
GenomeRNAii 25816.
NextBioi 35480121.
PROi O95379.
SOURCEi Search...

Gene expression databases

Bgeei O95379.
CleanExi HS_TNFAIP8.
ExpressionAtlasi O95379. baseline and differential.
Genevestigatori O95379.

Family and domain databases

InterProi IPR008477. DUF758.
[Graphical view ]
PANTHERi PTHR12757. PTHR12757. 1 hit.
Pfami PF05527. DUF758. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes."
    Horrevoets A.J.G., Fontijn R.D., van Zonneveld A.J., de Vries C.J.M., ten Cate J.W., Pannekoek H.
    Blood 93:3418-3431(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
    Tissue: Umbilical vein.
  2. "Identification of cellular factors involved in the differentiation of dendritic cells."
    Nietfeld W., Meyerhans A.F.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
    Tissue: Placenta.
  5. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Tissue: Stomach.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Urinary bladder.
  8. "Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein."
    Kumar D., Whiteside T.L., Kasid U.
    J. Biol. Chem. 275:2973-2978(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-198 (ISOFORM 3), IDENTIFICATION, FUNCTION, INDUCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Heart.
  9. "Nuclear factor-kappa B-inducible death effector domain-containing protein suppresses tumor necrosis factor-mediated apoptosis by inhibiting caspase-8 activity."
    You Z., Ouyang H., Lopatin D., Polver P.J., Wang C.-Y.
    J. Biol. Chem. 276:26398-26404(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  10. "Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells."
    Kumar D., Gokhale P., Broustas C., Chakravarty D., Ahmad I., Kasid U.
    Oncogene 23:612-616(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTFIP8_HUMAN
AccessioniPrimary (citable) accession number: O95379
Secondary accession number(s): B3KMH1
, B3KMI2, B7Z713, Q9P1Q1, Q9UER5, Q9UP47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3