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O95379 (TFIP8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor alpha-induced protein 8

Short name=TNF alpha-induced protein 8
Alternative name(s):
Head and neck tumor and metastasis-related protein
MDC-3.13
NF-kappa-B-inducible DED-containing protein
Short name=NDED
SCC-S2
TNF-induced protein GG2-1
Gene names
Name:TNFAIP8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. Ref.8 Ref.9 Ref.10

Subcellular location

Cytoplasm Ref.10.

Tissue specificity

Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle. Ref.1 Ref.8 Ref.10

Developmental stage

Expressed at high levels in the fetal liver, lung and kidney. Ref.8

Induction

By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB. Ref.8 Ref.9

Sequence similarities

Belongs to the TNFAIP8 family.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O95379-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O95379-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MHSEAEESKE → MA
Isoform 3 (identifier: O95379-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MHSEAEESKEV → M
Isoform 4 (identifier: O95379-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MHSEAEESKE → MTLPRYCEVVLLIAHGEKMLKL
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198Tumor necrosis factor alpha-induced protein 8
PRO_0000285718

Regions

Coiled coil49 – 8335 Potential

Natural variations

Alternative sequence1 – 1111MHSEAEESKEV → M in isoform 3.
VSP_024898
Alternative sequence1 – 1010MHSEAEESKE → MA in isoform 2.
VSP_024899
Alternative sequence1 – 1010MHSEAEESKE → MTLPRYCEVVLLIAHGEKML KL in isoform 4.
VSP_054827
Natural variant1511S → C.
Corresponds to variant rs3203922 [ dbSNP | Ensembl ].
VAR_032047

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: D9B8F6FCF9AFC2C3

FASTA19823,003
        10         20         30         40         50         60 
MHSEAEESKE VATDVFNSKN LAVQAQKKIL GKMVSKSIAT TLIDDTSSEV LDELYRVTRE 

        70         80         90        100        110        120 
YTQNKKEAEK IIKNLIKTVI KLAILYRNNQ FNQDELALME KFKKKVHQLA MTVVSFHQVD 

       130        140        150        160        170        180 
YTFDRNVLSR LLNECREMLH QIIQRHLTAK SHGRVNNVFD HFSDCEFLAA LYNPFGNFKP 

       190 
HLQKLCDGIN KMLDEENI 

« Hide

Isoform 2 [UniParc].

Checksum: 0DCD250217A1209C
Show »

FASTA19022,048
Isoform 3 [UniParc].

Checksum: 60452EC0A684F535
Show »

FASTA18821,877
Isoform 4 [UniParc].

Checksum: 44DE8FBED9290476
Show »

FASTA21024,385

References

« Hide 'large scale' references
[1]"Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes."
Horrevoets A.J.G., Fontijn R.D., van Zonneveld A.J., de Vries C.J.M., ten Cate J.W., Pannekoek H.
Blood 93:3418-3431(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
Tissue: Umbilical vein.
[2]"Identification of cellular factors involved in the differentiation of dendritic cells."
Nietfeld W., Meyerhans A.F.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
Tissue: Placenta.
[5]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Tissue: Stomach.
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain and Urinary bladder.
[8]"Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein."
Kumar D., Whiteside T.L., Kasid U.
J. Biol. Chem. 275:2973-2978(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-198 (ISOFORM 3), IDENTIFICATION, FUNCTION, INDUCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Heart.
[9]"Nuclear factor-kappa B-inducible death effector domain-containing protein suppresses tumor necrosis factor-mediated apoptosis by inhibiting caspase-8 activity."
You Z., Ouyang H., Lopatin D., Polver P.J., Wang C.-Y.
J. Biol. Chem. 276:26398-26404(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[10]"Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells."
Kumar D., Gokhale P., Broustas C., Chakravarty D., Ahmad I., Kasid U.
Oncogene 23:612-616(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[11]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF070671 mRNA. Translation: AAC83229.1.
AF099935 mRNA. Translation: AAC72975.1.
AF099936 mRNA. Translation: AAC72976.1.
CR457137 mRNA. Translation: CAG33418.1.
AK001850 mRNA. Translation: BAG50983.1.
AK001931 mRNA. Translation: BAG50994.1.
AK301281 mRNA. Translation: BAH13449.1.
AC008475 Genomic DNA. No translation available.
AC027320 Genomic DNA. No translation available.
AC035144 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW48914.1.
BC005352 mRNA. Translation: AAH05352.1.
BC007014 mRNA. Translation: AAH07014.1.
AF098933 mRNA. Translation: AAF29435.1.
CCDSCCDS47257.1. [O95379-3]
CCDS47258.1. [O95379-1]
RefSeqNP_001071122.1. NM_001077654.2. [O95379-3]
NP_001273742.1. NM_001286813.1. [O95379-1]
NP_001273743.1. NM_001286814.1. [O95379-4]
NP_001273744.1. NM_001286815.1.
NP_001273746.1. NM_001286817.1.
NP_055165.2. NM_014350.3. [O95379-1]
UniGeneHs.618488.
Hs.656274.

3D structure databases

ProteinModelPortalO95379.
SMRO95379. Positions 43-195.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117344. 14 interactions.
IntActO95379. 2 interactions.
MINTMINT-1473332.
STRING9606.ENSP00000408534.

Proteomic databases

MaxQBO95379.
PaxDbO95379.
PRIDEO95379.

Protocols and materials databases

DNASU25816.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000274456; ENSP00000274456; ENSG00000145779. [O95379-3]
ENST00000503646; ENSP00000421848; ENSG00000145779. [O95379-1]
ENST00000504771; ENSP00000422245; ENSG00000145779. [O95379-1]
ENST00000513374; ENSP00000427424; ENSG00000145779.
GeneID25816.
KEGGhsa:25816.
UCSCuc003ksg.3. human. [O95379-3]
uc003ksi.3. human. [O95379-1]

Organism-specific databases

CTD25816.
GeneCardsGC05P118604.
H-InvDBHIX0005115.
HGNCHGNC:17260. TNFAIP8.
HPAHPA057089.
MIM612111. gene.
neXtProtNX_O95379.
PharmGKBPA134957136.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG81900.
HOGENOMHOG000007708.
HOVERGENHBG053286.
InParanoidO95379.
OrthoDBEOG7P5T2H.
PhylomeDBO95379.
TreeFamTF323415.

Gene expression databases

ArrayExpressO95379.
BgeeO95379.
CleanExHS_TNFAIP8.
GenevestigatorO95379.

Family and domain databases

InterProIPR008477. DUF758.
[Graphical view]
PANTHERPTHR12757. PTHR12757. 1 hit.
PfamPF05527. DUF758. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTNFAIP8.
GenomeRNAi25816.
NextBio35480121.
PROO95379.
SOURCESearch...

Entry information

Entry nameTFIP8_HUMAN
AccessionPrimary (citable) accession number: O95379
Secondary accession number(s): B3KMH1 expand/collapse secondary AC list , B3KMI2, B7Z713, Q9P1Q1, Q9UER5, Q9UP47
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM