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O95379

- TFIP8_HUMAN

UniProt

O95379 - TFIP8_HUMAN

Protein

Tumor necrosis factor alpha-induced protein 8

Gene

TNFAIP8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.3 Publications

    GO - Molecular functioni

    1. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB

    GO - Biological processi

    1. negative regulation of apoptotic process Source: ProtInc
    2. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: GOC

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor alpha-induced protein 8
    Short name:
    TNF alpha-induced protein 8
    Alternative name(s):
    Head and neck tumor and metastasis-related protein
    MDC-3.13
    NF-kappa-B-inducible DED-containing protein
    Short name:
    NDED
    SCC-S2
    TNF-induced protein GG2-1
    Gene namesi
    Name:TNFAIP8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:17260. TNFAIP8.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134957136.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Tumor necrosis factor alpha-induced protein 8PRO_0000285718Add
    BLAST

    Proteomic databases

    MaxQBiO95379.
    PaxDbiO95379.
    PRIDEiO95379.

    Expressioni

    Tissue specificityi

    Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.3 Publications

    Developmental stagei

    Expressed at high levels in the fetal liver, lung and kidney.1 Publication

    Inductioni

    By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB.2 Publications

    Gene expression databases

    ArrayExpressiO95379.
    BgeeiO95379.
    CleanExiHS_TNFAIP8.
    GenevestigatoriO95379.

    Organism-specific databases

    HPAiHPA057089.

    Interactioni

    Protein-protein interaction databases

    BioGridi117344. 14 interactions.
    IntActiO95379. 2 interactions.
    MINTiMINT-1473332.
    STRINGi9606.ENSP00000408534.

    Structurei

    3D structure databases

    ProteinModelPortaliO95379.
    SMRiO95379. Positions 43-195.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili49 – 8335Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TNFAIP8 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG81900.
    HOGENOMiHOG000007708.
    HOVERGENiHBG053286.
    InParanoidiO95379.
    OrthoDBiEOG7P5T2H.
    PhylomeDBiO95379.
    TreeFamiTF323415.

    Family and domain databases

    InterProiIPR008477. DUF758.
    [Graphical view]
    PANTHERiPTHR12757. PTHR12757. 1 hit.
    PfamiPF05527. DUF758. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95379-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHSEAEESKE VATDVFNSKN LAVQAQKKIL GKMVSKSIAT TLIDDTSSEV    50
    LDELYRVTRE YTQNKKEAEK IIKNLIKTVI KLAILYRNNQ FNQDELALME 100
    KFKKKVHQLA MTVVSFHQVD YTFDRNVLSR LLNECREMLH QIIQRHLTAK 150
    SHGRVNNVFD HFSDCEFLAA LYNPFGNFKP HLQKLCDGIN KMLDEENI 198
    Length:198
    Mass (Da):23,003
    Last modified:May 1, 1999 - v1
    Checksum:iD9B8F6FCF9AFC2C3
    GO
    Isoform 2 (identifier: O95379-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-10: MHSEAEESKE → MA

    Show »
    Length:190
    Mass (Da):22,048
    Checksum:i0DCD250217A1209C
    GO
    Isoform 3 (identifier: O95379-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-11: MHSEAEESKEV → M

    Show »
    Length:188
    Mass (Da):21,877
    Checksum:i60452EC0A684F535
    GO
    Isoform 4 (identifier: O95379-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-10: MHSEAEESKE → MTLPRYCEVVLLIAHGEKMLKL

    Note: No experimental confirmation available.

    Show »
    Length:210
    Mass (Da):24,385
    Checksum:i44DE8FBED9290476
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti151 – 1511S → C.
    Corresponds to variant rs3203922 [ dbSNP | Ensembl ].
    VAR_032047

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1111MHSEAEESKEV → M in isoform 3. 3 PublicationsVSP_024898Add
    BLAST
    Alternative sequencei1 – 1010MHSEAEESKE → MA in isoform 2. 2 PublicationsVSP_024899
    Alternative sequencei1 – 1010MHSEAEESKE → MTLPRYCEVVLLIAHGEKML KL in isoform 4. 1 PublicationVSP_054827

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF070671 mRNA. Translation: AAC83229.1.
    AF099935 mRNA. Translation: AAC72975.1.
    AF099936 mRNA. Translation: AAC72976.1.
    CR457137 mRNA. Translation: CAG33418.1.
    AK001850 mRNA. Translation: BAG50983.1.
    AK001931 mRNA. Translation: BAG50994.1.
    AK301281 mRNA. Translation: BAH13449.1.
    AC008475 Genomic DNA. No translation available.
    AC027320 Genomic DNA. No translation available.
    AC035144 Genomic DNA. No translation available.
    CH471086 Genomic DNA. Translation: EAW48914.1.
    BC005352 mRNA. Translation: AAH05352.1.
    BC007014 mRNA. Translation: AAH07014.1.
    AF098933 mRNA. Translation: AAF29435.1.
    CCDSiCCDS47257.1. [O95379-3]
    CCDS47258.1. [O95379-1]
    CCDS68933.1. [O95379-4]
    RefSeqiNP_001071122.1. NM_001077654.2. [O95379-3]
    NP_001273742.1. NM_001286813.1. [O95379-1]
    NP_001273743.1. NM_001286814.1. [O95379-4]
    NP_001273744.1. NM_001286815.1.
    NP_001273746.1. NM_001286817.1.
    NP_055165.2. NM_014350.3. [O95379-1]
    UniGeneiHs.618488.
    Hs.656274.

    Genome annotation databases

    EnsembliENST00000274456; ENSP00000274456; ENSG00000145779. [O95379-3]
    ENST00000503646; ENSP00000421848; ENSG00000145779. [O95379-1]
    ENST00000504771; ENSP00000422245; ENSG00000145779. [O95379-1]
    ENST00000513374; ENSP00000427424; ENSG00000145779. [O95379-4]
    GeneIDi25816.
    KEGGihsa:25816.
    UCSCiuc003ksg.3. human. [O95379-3]
    uc003ksi.3. human. [O95379-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF070671 mRNA. Translation: AAC83229.1 .
    AF099935 mRNA. Translation: AAC72975.1 .
    AF099936 mRNA. Translation: AAC72976.1 .
    CR457137 mRNA. Translation: CAG33418.1 .
    AK001850 mRNA. Translation: BAG50983.1 .
    AK001931 mRNA. Translation: BAG50994.1 .
    AK301281 mRNA. Translation: BAH13449.1 .
    AC008475 Genomic DNA. No translation available.
    AC027320 Genomic DNA. No translation available.
    AC035144 Genomic DNA. No translation available.
    CH471086 Genomic DNA. Translation: EAW48914.1 .
    BC005352 mRNA. Translation: AAH05352.1 .
    BC007014 mRNA. Translation: AAH07014.1 .
    AF098933 mRNA. Translation: AAF29435.1 .
    CCDSi CCDS47257.1. [O95379-3 ]
    CCDS47258.1. [O95379-1 ]
    CCDS68933.1. [O95379-4 ]
    RefSeqi NP_001071122.1. NM_001077654.2. [O95379-3 ]
    NP_001273742.1. NM_001286813.1. [O95379-1 ]
    NP_001273743.1. NM_001286814.1. [O95379-4 ]
    NP_001273744.1. NM_001286815.1.
    NP_001273746.1. NM_001286817.1.
    NP_055165.2. NM_014350.3. [O95379-1 ]
    UniGenei Hs.618488.
    Hs.656274.

    3D structure databases

    ProteinModelPortali O95379.
    SMRi O95379. Positions 43-195.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117344. 14 interactions.
    IntActi O95379. 2 interactions.
    MINTi MINT-1473332.
    STRINGi 9606.ENSP00000408534.

    Proteomic databases

    MaxQBi O95379.
    PaxDbi O95379.
    PRIDEi O95379.

    Protocols and materials databases

    DNASUi 25816.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274456 ; ENSP00000274456 ; ENSG00000145779 . [O95379-3 ]
    ENST00000503646 ; ENSP00000421848 ; ENSG00000145779 . [O95379-1 ]
    ENST00000504771 ; ENSP00000422245 ; ENSG00000145779 . [O95379-1 ]
    ENST00000513374 ; ENSP00000427424 ; ENSG00000145779 . [O95379-4 ]
    GeneIDi 25816.
    KEGGi hsa:25816.
    UCSCi uc003ksg.3. human. [O95379-3 ]
    uc003ksi.3. human. [O95379-1 ]

    Organism-specific databases

    CTDi 25816.
    GeneCardsi GC05P118604.
    H-InvDB HIX0005115.
    HGNCi HGNC:17260. TNFAIP8.
    HPAi HPA057089.
    MIMi 612111. gene.
    neXtProti NX_O95379.
    PharmGKBi PA134957136.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG81900.
    HOGENOMi HOG000007708.
    HOVERGENi HBG053286.
    InParanoidi O95379.
    OrthoDBi EOG7P5T2H.
    PhylomeDBi O95379.
    TreeFami TF323415.

    Miscellaneous databases

    GeneWikii TNFAIP8.
    GenomeRNAii 25816.
    NextBioi 35480121.
    PROi O95379.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95379.
    Bgeei O95379.
    CleanExi HS_TNFAIP8.
    Genevestigatori O95379.

    Family and domain databases

    InterProi IPR008477. DUF758.
    [Graphical view ]
    PANTHERi PTHR12757. PTHR12757. 1 hit.
    Pfami PF05527. DUF758. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes."
      Horrevoets A.J.G., Fontijn R.D., van Zonneveld A.J., de Vries C.J.M., ten Cate J.W., Pannekoek H.
      Blood 93:3418-3431(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
      Tissue: Umbilical vein.
    2. "Identification of cellular factors involved in the differentiation of dendritic cells."
      Nietfeld W., Meyerhans A.F.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
      Tissue: Placenta.
    5. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Tissue: Stomach.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Urinary bladder.
    8. "Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein."
      Kumar D., Whiteside T.L., Kasid U.
      J. Biol. Chem. 275:2973-2978(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-198 (ISOFORM 3), IDENTIFICATION, FUNCTION, INDUCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Heart.
    9. "Nuclear factor-kappa B-inducible death effector domain-containing protein suppresses tumor necrosis factor-mediated apoptosis by inhibiting caspase-8 activity."
      You Z., Ouyang H., Lopatin D., Polver P.J., Wang C.-Y.
      J. Biol. Chem. 276:26398-26404(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    10. "Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells."
      Kumar D., Gokhale P., Broustas C., Chakravarty D., Ahmad I., Kasid U.
      Oncogene 23:612-616(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTFIP8_HUMAN
    AccessioniPrimary (citable) accession number: O95379
    Secondary accession number(s): B3KMH1
    , B3KMI2, B7Z713, Q9P1Q1, Q9UER5, Q9UP47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3