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O95373

- IPO7_HUMAN

UniProt

O95373 - IPO7_HUMAN

Protein

Importin-7

Gene

IPO7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In vitro, mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.3 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. Ran GTPase binding Source: ProtInc
    3. small GTPase regulator activity Source: ProtInc
    4. transporter activity Source: ProtInc

    GO - Biological processi

    1. protein import into nucleus Source: Ensembl
    2. regulation of catalytic activity Source: GOC
    3. signal transduction Source: ProtInc
    4. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Importin-7
    Short name:
    Imp7
    Alternative name(s):
    Ran-binding protein 7
    Short name:
    RanBP7
    Gene namesi
    Name:IPO7
    Synonyms:RANBP7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:9852. IPO7.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB
    3. nuclear pore Source: ProtInc

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi61 – 611K → A or D: Lowered affinity for RanGTP-binding. 1 Publication

    Organism-specific databases

    PharmGKBiPA34213.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10381038Importin-7PRO_0000120750Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine4 Publications
    Modified residuei886 – 8861Phosphoserine1 Publication
    Modified residuei898 – 8981Phosphothreonine1 Publication
    Modified residuei903 – 9031Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO95373.
    PaxDbiO95373.
    PRIDEiO95373.

    PTM databases

    PhosphoSiteiO95373.

    Expressioni

    Gene expression databases

    ArrayExpressiO95373.
    BgeeiO95373.
    CleanExiHS_IPO7.
    GenevestigatoriO95373.

    Organism-specific databases

    HPAiHPA019002.

    Interactioni

    Subunit structurei

    Interacts with H2A, H2B, H3 and H4 histones By similarity. Forms a heterodimer with KPNB1. Interacts with KPNB1, SNUPN, XPO1, RPL23A, RPS7, RPL5 and HIV-1 reverse transcription complex integrase. Binds directly to nuclear pore complexes By similarity. Interacts with H2A, H2B, H3 and H4 histones. Binds to HIV-1 Rev.By similarity5 Publications

    Protein-protein interaction databases

    BioGridi115782. 34 interactions.
    DIPiDIP-32574N.
    IntActiO95373. 15 interactions.
    MINTiMINT-5003960.
    STRINGi9606.ENSP00000369042.

    Structurei

    3D structure databases

    ProteinModelPortaliO95373.
    SMRiO95373. Positions 2-440.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 10180Importin N-terminalPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi885 – 95773Asp-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the importin beta family.Curated
    Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5656.
    HOGENOMiHOG000006586.
    HOVERGENiHBG006824.
    InParanoidiO95373.
    OMAiYKEKQYV.
    OrthoDBiEOG7TF787.
    PhylomeDBiO95373.
    TreeFamiTF300634.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR013713. Cse1.
    IPR001494. Importin-beta_N.
    [Graphical view]
    PfamiPF08506. Cse1. 1 hit.
    PF03810. IBN_N. 1 hit.
    [Graphical view]
    SMARTiSM00913. IBN_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95373-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPNTIIEAL RGTMDPALRE AAERQLNEAH KSLNFVSTLL QITMSEQLDL     50
    PVRQAGVIYL KNMITQYWPD RETAPGDISP YTIPEEDRHC IRENIVEAII 100
    HSPELIRVQL TTCIHHIIKH DYPSRWTAIV DKIGFYLQSD NSACWLGILL 150
    CLYQLVKNYE YKKPEERSPL VAAMQHFLPV LKDRFIQLLS DQSDQSVLIQ 200
    KQIFKIFYAL VQYTLPLELI NQQNLTEWIE ILKTVVNRDV PNETLQVEED 250
    DRPELPWWKC KKWALHILAR LFERYGSPGN VSKEYNEFAE VFLKAFAVGV 300
    QQVLLKVLYQ YKEKQYMAPR VLQQTLNYIN QGVSHALTWK NLKPHIQGII 350
    QDVIFPLMCY TDADEELWQE DPYEYIRMKF DVFEDFISPT TAAQTLLFTA 400
    CSKRKEVLQK TMGFCYQILT EPNADPRKKD GALHMIGSLA EILLKKKIYK 450
    DQMEYMLQNH VFPLFSSELG YMRARACWVL HYFCEVKFKS DQNLQTALEL 500
    TRRCLIDDRE MPVKVEAAIA LQVLISNQEK AKEYITPFIR PVMQALLHII 550
    RETENDDLTN VIQKMICEYS EEVTPIAVEM TQHLAMTFNQ VIQTGPDEEG 600
    SDDKAVTAMG ILNTIDTLLS VVEDHKEITQ QLEGICLQVI GTVLQQHVLE 650
    FYEEIFSLAH SLTCQQVSPQ MWQLLPLVFE VFQQDGFDYF TDMMPLLHNY 700
    VTVDTDTLLS DTKYLEMIYS MCKKVLTGVA GEDAECHAAK LLEVIILQCK 750
    GRGIDQCIPL FVEAALERLT REVKTSELRT MCLQVAIAAL YYNPHLLLNT 800
    LENLRFPNNV EPVTNHFITQ WLNDVDCFLG LHDRKMCVLG LCALIDMEQI 850
    PQVLNQVSGQ ILPAFILLFN GLKRAYACHA EHENDSDDDD EAEDDDETEE 900
    LGSDEDDIDE DGQEYLEILA KQAGEDGDDE DWEEDDAEET ALEGYSTIID 950
    DEDNPVDEYQ IFKAIFQTIQ NRNPVWYQAL THGLNEEQRK QLQDIATLAD 1000
    QRRAAHESKM IEKHGGYKFS APVVPSSFNF GGPAPGMN 1038
    Length:1,038
    Mass (Da):119,517
    Last modified:May 1, 1999 - v1
    Checksum:i355237CA1DA2D313
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti111 – 1111T → N.
    Corresponds to variant rs11042340 [ dbSNP | Ensembl ].
    VAR_050003

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF098799 mRNA. Translation: AAC68903.1.
    AK312885 mRNA. Translation: BAG35733.1.
    AC055845 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68593.1.
    BC114929 mRNA. Translation: AAI14930.1.
    AJ295844 Genomic DNA. Translation: CAC17609.1.
    AL137335 mRNA. Translation: CAB70698.1.
    CCDSiCCDS31425.1.
    PIRiT46501.
    RefSeqiNP_006382.1. NM_006391.2.
    UniGeneiHs.744911.

    Genome annotation databases

    EnsembliENST00000379719; ENSP00000369042; ENSG00000205339.
    GeneIDi10527.
    KEGGihsa:10527.
    UCSCiuc001mho.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF098799 mRNA. Translation: AAC68903.1 .
    AK312885 mRNA. Translation: BAG35733.1 .
    AC055845 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68593.1 .
    BC114929 mRNA. Translation: AAI14930.1 .
    AJ295844 Genomic DNA. Translation: CAC17609.1 .
    AL137335 mRNA. Translation: CAB70698.1 .
    CCDSi CCDS31425.1.
    PIRi T46501.
    RefSeqi NP_006382.1. NM_006391.2.
    UniGenei Hs.744911.

    3D structure databases

    ProteinModelPortali O95373.
    SMRi O95373. Positions 2-440.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115782. 34 interactions.
    DIPi DIP-32574N.
    IntActi O95373. 15 interactions.
    MINTi MINT-5003960.
    STRINGi 9606.ENSP00000369042.

    PTM databases

    PhosphoSitei O95373.

    Proteomic databases

    MaxQBi O95373.
    PaxDbi O95373.
    PRIDEi O95373.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379719 ; ENSP00000369042 ; ENSG00000205339 .
    GeneIDi 10527.
    KEGGi hsa:10527.
    UCSCi uc001mho.3. human.

    Organism-specific databases

    CTDi 10527.
    GeneCardsi GC11P009362.
    HGNCi HGNC:9852. IPO7.
    HPAi HPA019002.
    MIMi 605586. gene.
    neXtProti NX_O95373.
    PharmGKBi PA34213.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5656.
    HOGENOMi HOG000006586.
    HOVERGENi HBG006824.
    InParanoidi O95373.
    OMAi YKEKQYV.
    OrthoDBi EOG7TF787.
    PhylomeDBi O95373.
    TreeFami TF300634.

    Miscellaneous databases

    ChiTaRSi IPO7. human.
    GeneWikii IPO7.
    GenomeRNAii 10527.
    NextBioi 39938.
    PROi O95373.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95373.
    Bgeei O95373.
    CleanExi HS_IPO7.
    Genevestigatori O95373.

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR013713. Cse1.
    IPR001494. Importin-beta_N.
    [Graphical view ]
    Pfami PF08506. Cse1. 1 hit.
    PF03810. IBN_N. 1 hit.
    [Graphical view ]
    SMARTi SM00913. IBN_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    PROSITEi PS50166. IMPORTIN_B_NT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells."
      Jaekel S., Goerlich D.
      EMBO J. 17:4491-4502(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RPL23A; RPS7; RPL5 AND KPNB1.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-11, ACETYLATION AT MET-1.
      Tissue: Platelet.
    7. "Comparative sequencing of a 1 Mb region in man (chromosome 11p15) and mouse (chromosome 7)."
      Cichutek A., Winterpacht A., Hankeln T., Schmidt E.R., Zabel B.U.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-1038.
      Tissue: Blood.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 831-1038.
      Tissue: Testis.
    9. Cited for: CHARACTERIZATION.
    10. "The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1."
      Jaekel S., Albig W., Kutay U., Bischoff F.R., Schwamborn K., Doenecke D., Goerlich D.
      EMBO J. 18:2411-2423(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH H1 HISTONE AND KPNB1, MUTAGENESIS OF LYS-61.
    11. Cited for: IDENTIFICATION IN AN EXPORT RECEPTOR COMPLEX, INTERACTION WITH KPNB1; SNUPN AND XPO1.
    12. "Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7."
      Fassati A., Goerlich D., Harrison I., Zaytseva L., Mingot J.-M.
      EMBO J. 22:3675-3685(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH INTEGRASE OF HIV-1 REVERSE TRANSCRIPTION COMPLEX.
    13. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1."
      Arnold M., Nath A., Hauber J., Kehlenbach R.H.
      J. Biol. Chem. 281:20883-20890(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HIV-1 REV.
    15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-886; THR-898 AND SER-903, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiIPO7_HUMAN
    AccessioniPrimary (citable) accession number: O95373
    Secondary accession number(s): A6NNM5
    , B2R786, Q1RMF7, Q9H177, Q9NTE3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3