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O95373

- IPO7_HUMAN

UniProt

O95373 - IPO7_HUMAN

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Protein

Importin-7

Gene
IPO7, RANBP7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In vitro, mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.3 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. Ran GTPase binding Source: ProtInc
  3. small GTPase regulator activity Source: ProtInc
  4. transporter activity Source: ProtInc

GO - Biological processi

  1. protein import into nucleus Source: Ensembl
  2. regulation of catalytic activity Source: GOC
  3. signal transduction Source: ProtInc
  4. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin-7
Short name:
Imp7
Alternative name(s):
Ran-binding protein 7
Short name:
RanBP7
Gene namesi
Name:IPO7
Synonyms:RANBP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:9852. IPO7.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nuclear pore Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi61 – 611K → A or D: Lowered affinity for RanGTP-binding. 1 Publication

Organism-specific databases

PharmGKBiPA34213.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10381038Importin-7PRO_0000120750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine4 Publications
Modified residuei886 – 8861Phosphoserine1 Publication
Modified residuei898 – 8981Phosphothreonine1 Publication
Modified residuei903 – 9031Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO95373.
PaxDbiO95373.
PRIDEiO95373.

PTM databases

PhosphoSiteiO95373.

Expressioni

Gene expression databases

ArrayExpressiO95373.
BgeeiO95373.
CleanExiHS_IPO7.
GenevestigatoriO95373.

Organism-specific databases

HPAiHPA019002.

Interactioni

Subunit structurei

Interacts with H2A, H2B, H3 and H4 histones By similarity. Forms a heterodimer with KPNB1. Interacts with KPNB1, SNUPN, XPO1, RPL23A, RPS7, RPL5 and HIV-1 reverse transcription complex integrase. Binds directly to nuclear pore complexes By similarity. Interacts with H2A, H2B, H3 and H4 histones. Binds to HIV-1 Rev.5 Publications

Protein-protein interaction databases

BioGridi115782. 34 interactions.
DIPiDIP-32574N.
IntActiO95373. 14 interactions.
MINTiMINT-5003960.
STRINGi9606.ENSP00000369042.

Structurei

3D structure databases

ProteinModelPortaliO95373.
SMRiO95373. Positions 2-440.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 10180Importin N-terminalAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi885 – 95773Asp-richAdd
BLAST

Sequence similaritiesi

Belongs to the importin beta family.

Phylogenomic databases

eggNOGiCOG5656.
HOGENOMiHOG000006586.
HOVERGENiHBG006824.
InParanoidiO95373.
OMAiYKEKQYV.
OrthoDBiEOG7TF787.
PhylomeDBiO95373.
TreeFamiTF300634.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013713. Cse1.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF08506. Cse1. 1 hit.
PF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95373-1 [UniParc]FASTAAdd to Basket

« Hide

MDPNTIIEAL RGTMDPALRE AAERQLNEAH KSLNFVSTLL QITMSEQLDL     50
PVRQAGVIYL KNMITQYWPD RETAPGDISP YTIPEEDRHC IRENIVEAII 100
HSPELIRVQL TTCIHHIIKH DYPSRWTAIV DKIGFYLQSD NSACWLGILL 150
CLYQLVKNYE YKKPEERSPL VAAMQHFLPV LKDRFIQLLS DQSDQSVLIQ 200
KQIFKIFYAL VQYTLPLELI NQQNLTEWIE ILKTVVNRDV PNETLQVEED 250
DRPELPWWKC KKWALHILAR LFERYGSPGN VSKEYNEFAE VFLKAFAVGV 300
QQVLLKVLYQ YKEKQYMAPR VLQQTLNYIN QGVSHALTWK NLKPHIQGII 350
QDVIFPLMCY TDADEELWQE DPYEYIRMKF DVFEDFISPT TAAQTLLFTA 400
CSKRKEVLQK TMGFCYQILT EPNADPRKKD GALHMIGSLA EILLKKKIYK 450
DQMEYMLQNH VFPLFSSELG YMRARACWVL HYFCEVKFKS DQNLQTALEL 500
TRRCLIDDRE MPVKVEAAIA LQVLISNQEK AKEYITPFIR PVMQALLHII 550
RETENDDLTN VIQKMICEYS EEVTPIAVEM TQHLAMTFNQ VIQTGPDEEG 600
SDDKAVTAMG ILNTIDTLLS VVEDHKEITQ QLEGICLQVI GTVLQQHVLE 650
FYEEIFSLAH SLTCQQVSPQ MWQLLPLVFE VFQQDGFDYF TDMMPLLHNY 700
VTVDTDTLLS DTKYLEMIYS MCKKVLTGVA GEDAECHAAK LLEVIILQCK 750
GRGIDQCIPL FVEAALERLT REVKTSELRT MCLQVAIAAL YYNPHLLLNT 800
LENLRFPNNV EPVTNHFITQ WLNDVDCFLG LHDRKMCVLG LCALIDMEQI 850
PQVLNQVSGQ ILPAFILLFN GLKRAYACHA EHENDSDDDD EAEDDDETEE 900
LGSDEDDIDE DGQEYLEILA KQAGEDGDDE DWEEDDAEET ALEGYSTIID 950
DEDNPVDEYQ IFKAIFQTIQ NRNPVWYQAL THGLNEEQRK QLQDIATLAD 1000
QRRAAHESKM IEKHGGYKFS APVVPSSFNF GGPAPGMN 1038
Length:1,038
Mass (Da):119,517
Last modified:May 1, 1999 - v1
Checksum:i355237CA1DA2D313
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti111 – 1111T → N.
Corresponds to variant rs11042340 [ dbSNP | Ensembl ].
VAR_050003

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF098799 mRNA. Translation: AAC68903.1.
AK312885 mRNA. Translation: BAG35733.1.
AC055845 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68593.1.
BC114929 mRNA. Translation: AAI14930.1.
AJ295844 Genomic DNA. Translation: CAC17609.1.
AL137335 mRNA. Translation: CAB70698.1.
CCDSiCCDS31425.1.
PIRiT46501.
RefSeqiNP_006382.1. NM_006391.2.
UniGeneiHs.744911.

Genome annotation databases

EnsembliENST00000379719; ENSP00000369042; ENSG00000205339.
GeneIDi10527.
KEGGihsa:10527.
UCSCiuc001mho.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF098799 mRNA. Translation: AAC68903.1 .
AK312885 mRNA. Translation: BAG35733.1 .
AC055845 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68593.1 .
BC114929 mRNA. Translation: AAI14930.1 .
AJ295844 Genomic DNA. Translation: CAC17609.1 .
AL137335 mRNA. Translation: CAB70698.1 .
CCDSi CCDS31425.1.
PIRi T46501.
RefSeqi NP_006382.1. NM_006391.2.
UniGenei Hs.744911.

3D structure databases

ProteinModelPortali O95373.
SMRi O95373. Positions 2-440.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115782. 34 interactions.
DIPi DIP-32574N.
IntActi O95373. 14 interactions.
MINTi MINT-5003960.
STRINGi 9606.ENSP00000369042.

PTM databases

PhosphoSitei O95373.

Proteomic databases

MaxQBi O95373.
PaxDbi O95373.
PRIDEi O95373.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379719 ; ENSP00000369042 ; ENSG00000205339 .
GeneIDi 10527.
KEGGi hsa:10527.
UCSCi uc001mho.3. human.

Organism-specific databases

CTDi 10527.
GeneCardsi GC11P009362.
HGNCi HGNC:9852. IPO7.
HPAi HPA019002.
MIMi 605586. gene.
neXtProti NX_O95373.
PharmGKBi PA34213.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5656.
HOGENOMi HOG000006586.
HOVERGENi HBG006824.
InParanoidi O95373.
OMAi YKEKQYV.
OrthoDBi EOG7TF787.
PhylomeDBi O95373.
TreeFami TF300634.

Miscellaneous databases

ChiTaRSi IPO7. human.
GeneWikii IPO7.
GenomeRNAii 10527.
NextBioi 39938.
PROi O95373.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95373.
Bgeei O95373.
CleanExi HS_IPO7.
Genevestigatori O95373.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013713. Cse1.
IPR001494. Importin-beta_N.
[Graphical view ]
Pfami PF08506. Cse1. 1 hit.
PF03810. IBN_N. 1 hit.
[Graphical view ]
SMARTi SM00913. IBN_N. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
PROSITEi PS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells."
    Jaekel S., Goerlich D.
    EMBO J. 17:4491-4502(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RPL23A; RPS7; RPL5 AND KPNB1.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-11, ACETYLATION AT MET-1.
    Tissue: Platelet.
  7. "Comparative sequencing of a 1 Mb region in man (chromosome 11p15) and mouse (chromosome 7)."
    Cichutek A., Winterpacht A., Hankeln T., Schmidt E.R., Zabel B.U.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-1038.
    Tissue: Blood.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 831-1038.
    Tissue: Testis.
  9. Cited for: CHARACTERIZATION.
  10. "The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1."
    Jaekel S., Albig W., Kutay U., Bischoff F.R., Schwamborn K., Doenecke D., Goerlich D.
    EMBO J. 18:2411-2423(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH H1 HISTONE AND KPNB1, MUTAGENESIS OF LYS-61.
  11. Cited for: IDENTIFICATION IN AN EXPORT RECEPTOR COMPLEX, INTERACTION WITH KPNB1; SNUPN AND XPO1.
  12. "Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7."
    Fassati A., Goerlich D., Harrison I., Zaytseva L., Mingot J.-M.
    EMBO J. 22:3675-3685(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH INTEGRASE OF HIV-1 REVERSE TRANSCRIPTION COMPLEX.
  13. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1."
    Arnold M., Nath A., Hauber J., Kehlenbach R.H.
    J. Biol. Chem. 281:20883-20890(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HIV-1 REV.
  15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-886; THR-898 AND SER-903, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIPO7_HUMAN
AccessioniPrimary (citable) accession number: O95373
Secondary accession number(s): A6NNM5
, B2R786, Q1RMF7, Q9H177, Q9NTE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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