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Protein

Acyl-protein thioesterase 2

Gene

LYPLA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity (By similarity). Deacylates GAP43.By similarity1 Publication

Catalytic activityi

Palmitoyl-protein + H2O = palmitate + protein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei122Charge relay systemBy similarity1
Active sitei176Charge relay systemBy similarity1
Active sitei210Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-373760. L1CAM interactions.

Protein family/group databases

ESTHERihuman-LYPLA2. LYsophospholipase_carboxylesterase.
MEROPSiS09.025.

Chemistry databases

SwissLipidsiSLP:000001479.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-protein thioesterase 2 (EC:3.1.2.-)
Short name:
APT-2
Alternative name(s):
Lysophospholipase II
Short name:
LPL-II
Short name:
LysoPLA II
Gene namesi
Name:LYPLA2
Synonyms:APT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6738. LYPLA2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi11313.
OpenTargetsiENSG00000011009.
PharmGKBiPA30500.

Chemistry databases

ChEMBLiCHEMBL1932891.

Polymorphism and mutation databases

BioMutaiLYPLA2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001022711 – 231Acyl-protein thioesterase 2Add BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95372.
MaxQBiO95372.
PaxDbiO95372.
PeptideAtlasiO95372.
PRIDEiO95372.

2D gel databases

OGPiO95372.

PTM databases

iPTMnetiO95372.
PhosphoSitePlusiO95372.
SwissPalmiO95372.

Expressioni

Gene expression databases

BgeeiENSG00000011009.
CleanExiHS_LYPLA2.
ExpressionAtlasiO95372. baseline and differential.
GenevisibleiO95372. HS.

Organism-specific databases

HPAiHPA063151.

Interactioni

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi116444. 22 interactors.
IntActiO95372. 5 interactors.
STRINGi9606.ENSP00000363638.

Chemistry databases

BindingDBiO95372.

Structurei

Secondary structure

1231
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 17Combined sources7
Beta strandi25 – 30Combined sources6
Helixi38 – 45Combined sources8
Beta strandi52 – 57Combined sources6
Beta strandi61 – 63Combined sources3
Helixi65 – 67Combined sources3
Beta strandi71 – 73Combined sources3
Helixi89 – 108Combined sources20
Helixi113 – 115Combined sources3
Beta strandi116 – 121Combined sources6
Helixi123 – 133Combined sources11
Beta strandi140 – 146Combined sources7
Helixi152 – 154Combined sources3
Turni155 – 158Combined sources4
Helixi161 – 165Combined sources5
Beta strandi167 – 173Combined sources7
Beta strandi177 – 179Combined sources3
Helixi181 – 192Combined sources12
Helixi197 – 199Combined sources3
Beta strandi200 – 205Combined sources6
Helixi214 – 227Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5SYNX-ray1.64A/B/C/D1-231[»]
ProteinModelPortaliO95372.
SMRiO95372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2112. Eukaryota.
COG0400. LUCA.
GeneTreeiENSGT00390000009648.
HOGENOMiHOG000260139.
HOVERGENiHBG052378.
InParanoidiO95372.
KOiK06130.
OMAiWLPLHRN.
OrthoDBiEOG091G080L.
PhylomeDBiO95372.
TreeFamiTF314619.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR003140. PLipase/COase/thioEstase.
PfamiView protein in Pfam
PF02230. Abhydrolase_2. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

O95372-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGNTMSVPL LTDAATVSGA ERETAAVIFL HGLGDTGHSW ADALSTIRLP
60 70 80 90 100
HVKYICPHAP RIPVTLNMKM VMPSWFDLMG LSPDAPEDEA GIKKAAENIK
110 120 130 140 150
ALIEHEMKNG IPANRIVLGG FSQGGALSLY TALTCPHPLA GIVALSCWLP
160 170 180 190 200
LHRAFPQAAN GSAKDLAILQ CHGELDPMVP VRFGALTAEK LRSVVTPARV
210 220 230
QFKTYPGVMH SSCPQEMAAV KEFLEKLLPP V
Length:231
Mass (Da):24,737
Last modified:May 1, 1999 - v1
Checksum:i813C9C71757C5135
GO

Sequence cautioni

The sequence AAP97210 differs from that shown. Reason: Frameshift at positions 5, 164 and 179.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098668 mRNA. Translation: AAC72844.1.
AF090423 mRNA. Translation: AAP97210.1. Frameshift.
AL031295 Genomic DNA. No translation available.
BC017034 mRNA. Translation: AAH17034.1.
BC017193 mRNA. Translation: AAH17193.1.
CCDSiCCDS241.1.
RefSeqiNP_009191.1. NM_007260.2.
UniGeneiHs.533479.

Genome annotation databases

EnsembliENST00000374514; ENSP00000363638; ENSG00000011009.
GeneIDi11313.
KEGGihsa:11313.
UCSCiuc001bht.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098668 mRNA. Translation: AAC72844.1.
AF090423 mRNA. Translation: AAP97210.1. Frameshift.
AL031295 Genomic DNA. No translation available.
BC017034 mRNA. Translation: AAH17034.1.
BC017193 mRNA. Translation: AAH17193.1.
CCDSiCCDS241.1.
RefSeqiNP_009191.1. NM_007260.2.
UniGeneiHs.533479.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5SYNX-ray1.64A/B/C/D1-231[»]
ProteinModelPortaliO95372.
SMRiO95372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116444. 22 interactors.
IntActiO95372. 5 interactors.
STRINGi9606.ENSP00000363638.

Chemistry databases

BindingDBiO95372.
ChEMBLiCHEMBL1932891.
SwissLipidsiSLP:000001479.

Protein family/group databases

ESTHERihuman-LYPLA2. LYsophospholipase_carboxylesterase.
MEROPSiS09.025.

PTM databases

iPTMnetiO95372.
PhosphoSitePlusiO95372.
SwissPalmiO95372.

Polymorphism and mutation databases

BioMutaiLYPLA2.

2D gel databases

OGPiO95372.

Proteomic databases

EPDiO95372.
MaxQBiO95372.
PaxDbiO95372.
PeptideAtlasiO95372.
PRIDEiO95372.

Protocols and materials databases

DNASUi11313.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374514; ENSP00000363638; ENSG00000011009.
GeneIDi11313.
KEGGihsa:11313.
UCSCiuc001bht.4. human.

Organism-specific databases

CTDi11313.
DisGeNETi11313.
GeneCardsiLYPLA2.
HGNCiHGNC:6738. LYPLA2.
HPAiHPA063151.
neXtProtiNX_O95372.
OpenTargetsiENSG00000011009.
PharmGKBiPA30500.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2112. Eukaryota.
COG0400. LUCA.
GeneTreeiENSGT00390000009648.
HOGENOMiHOG000260139.
HOVERGENiHBG052378.
InParanoidiO95372.
KOiK06130.
OMAiWLPLHRN.
OrthoDBiEOG091G080L.
PhylomeDBiO95372.
TreeFamiTF314619.

Enzyme and pathway databases

ReactomeiR-HSA-373760. L1CAM interactions.

Miscellaneous databases

GenomeRNAii11313.
PROiPR:O95372.

Gene expression databases

BgeeiENSG00000011009.
CleanExiHS_LYPLA2.
ExpressionAtlasiO95372. baseline and differential.
GenevisibleiO95372. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR003140. PLipase/COase/thioEstase.
PfamiView protein in Pfam
PF02230. Abhydrolase_2. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLYPA2_HUMAN
AccessioniPrimary (citable) accession number: O95372
Secondary accession number(s): Q7Z4Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 1999
Last modified: April 12, 2017
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.